CN103520052B - Bletilla striata extract is preparing the application in oral care product - Google Patents
Bletilla striata extract is preparing the application in oral care product Download PDFInfo
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Abstract
The open bletilla striata extract of the present invention is preparing the application in oral care product, namely in the technique preparing oral care implement, bletilla striata extract is added in oral care product as the active component preventing and treating gingival hemorrhage, compared with prior art, the present invention has the effect of significant control gingival hemorrhage.
Description
Technical field
The present invention relates to oral care implement technical field, especially a kind of bletilla striata extract is preparing the application in oral care product.
Background technology
The oral care product that people commonly use is toothpaste, collutory, dentifrice etc. mainly, and its basic function is exactly cleaning teeth, and protection gingiva, safeguards the hygiene and health in oral cavity.Along with the raising of people's living standard, the health care consciousness of consumer constantly strengthens, more requirement be it is also proposed to oral care product, the requirement of people to toothpaste and collutory also add effect that some can assist prevention oral disease except having this basic function that cleans the teeth, therefore, toothpaste in the market and collutory almost all add the functional component for the various oral disease of control, therefore the product that oral care product both domestic and external has a various functional type becomes the market mainstream, is mostly wherein to add western medicine composition to realize.
But along with the development of economy, along with day by day manifesting of the problem such as environmental pollution, ecological disturbance, the safety of consumer to product is more and more paid close attention to, thus more and more advocates natural and safe product.Interpolation effectively can prevent and treat the oral care product of various oral disease Chinese herbal medicine, little with its toxic and side effects, and green, environmental protection, safety high and be doubly subject to the favor of people, on market, the consumption demand of this series products is in continuous growth.In addition, along with the development of modernization of Chinese medicine technology, have also been obtained fine development to the method that Chinese medicine study of active components utilizes, this prevents oral disease to provide good technical support for oral care product utilizes active ingredient of Chinese herbs to assist.
Gingival hemorrhage is one of department of stomatology common sympton, and what refer to that gingiva is idiopathic or cause due to minimal irritation bleeds on a small quantity.The lighter show as only sucking, brush teeth, when chewing harder food in saliva with the blood streak, severe one is when gingiva is subject to minimal irritation and hemorrhage more even hematostaxis.Generally speaking, the chronic inflammatory disease of gingiva is the common cause of gingival hemorrhage, therefore gingival hemorrhage is more common in periodontitis and gingivitis patients.Show according to interrelated data, due to bad dietary habit and think little of oral hygiene, gingival hemorrhage is in various degree there is in increasing crowd at different times, for this reason, be necessary the needs complying with market development, the oral care product of a kind of special control gingival hemorrhage of exploitation using Chinese herbal medicine extract safely and effectively as active component.
Summary of the invention
The problem that the present invention solves is to provide bletilla striata extract and is preparing the application scheme in oral care product, and this oral cavity nursing health products has obvious anastalsis.
Bletilla striata extract of the present invention is exactly bletilla striata extract joined in oral care product using the form of single medicinal material as the active component of anastalsis in the technique preparing oral care implement preparing the application scheme in oral care product.
In technique scheme, scheme can also be more specifically: described Bletilla is preparing the raw material as anastalsis in toothpaste technique.
Further: the percentage by weight of described Bletilla in total mastic of toothpaste is 1.0-10.0%, and described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
Further: described Bletilla is preparing the raw material as anastalsis in collutory technique.
Further: the percentage by weight of described Bletilla in collutory raw material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
Further: described Bletilla is preparing the raw material as anastalsis in dentifrice technique.
Further: the percentage by weight of described Bletilla in dentifrice raw material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
Further: described Bletilla is preparing the raw material as anastalsis in throat lozenge technique.
Further: the percentage by weight of described Bletilla in throat lozenge raw material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
Further: described Bletilla is preparing the raw material as anastalsis in chewing gum technique.
Further: the percentage by weight of described Bletilla in chewing-gum material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
The said Pseudobulbus Bletillae (Rhizoma Bletillae) of the present invention is the dry stem block for orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletillastriata (Thund.) Reichb.f..Nature and flavor are pungent, bitter, sweet, puckery, are slightly cold.Return lung, liver, stomach warp.Major function astringing to arrest bleeding, detumescence and promoting granulation.Be mainly used in treatment hemoptysis to spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
The Pseudobulbus Bletillae (Rhizoma Bletillae) mentioned by the present invention is the dry root of the rosaceous plant Pseudobulbus Bletillae (Rhizoma Bletillae) or the Pseudobulbus Bletillae (Rhizoma Bletillae) that comes into leaves.
Be use with the form of bletilla striata extract in the present invention, bletilla striata extract extracting method is that the Pseudobulbus Bletillae (Rhizoma Bletillae) is broken into granularity, extracts 3 hours with the alcohol heating reflux of 10 times amount, extracts 3 times, then extracting solution concentrating under reduced pressure is become extractum or be dried to powdery.The extracting method of the Pseudobulbus Bletillae (Rhizoma Bletillae) is not limited to said method, and the additive method such as supercritical extraction, ultrasonic extraction also can be adopted to extract; Also existing commercially available Bletilla can be used.
The content of the bletilla striata extract described in the present invention is all the pure extract powder of 100% for active component, but is not limited to pure extract powder, also can be other form such as extracting solution or extractum; In time being applied to toothpaste with other forms as extracting solution, the addition in formula should be converted to the amount of pure form of extract disclosed in the present invention.
The present invention confirms through pharmacological evaluation, and the oral care product containing bletilla striata extract has the effect of preventing and treating gingival hemorrhage, antiinflammatory significantly.
The present invention, to the anastalsis experiment carrying out laboratory animal white rabbit liver local woanded surface bleeding due to trauma containing the toothpaste of bletilla striata extract, makes positive control and blank is observed simultaneously.Experimental result shows, this bletilla striata extract toothpaste and positive control medicine YUNNAN BAIYAO, compare with blank group, all has obvious anastalsis to rabbit liver local woanded surface bleeding due to trauma, there were significant differences statistically, shows that this bletilla striata extract toothpaste has significant anastalsis.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.In following each embodiment, involved percentage ratio except as otherwise noted, is all calculate by weight percentage.
embodiment 1-5: the application of bletilla striata extract in toothpaste.
the toothpaste constitutive material of embodiment 1-5 and weight percent content are as following table:
the toothpaste making process of embodiment 2 adopts the one-step method preparation of conventional medicine toothpaste:
the liquid material such as pure water, sorbitol, bletilla striata extract measured is dropped in temporary cylinder; In pre-dispersed still, drop into the calcite in powder, saccharin sodium sodium, carboxycellulose sodium, sodium lauryl sulphate, the nipalgin that measure mix the powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 50 minutes, drop into essence, close colloid mill, agitator, scraper successively after 10 minutes, vacuum breaker, stop vacuum pump, make after sampling detection is qualified.
the preparation method of other embodiment above-mentioned is with reference to embodiment 2.
embodiment 6-10: the application of bletilla striata extract in collutory.
the collutory constitutive material of embodiment 6-10 and weight percent content are as following table:
The preparation method of above-described embodiment 7 collutory is:
First bletilla striata extract, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol and is placed in temporary pot, sorbitol, deionization, castor oil hydrogenated-40 are added in agitated kettle and stirs 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stir 10 minutes, finally add essence and stir 5 minutes, stop stirring, make after sampling detection is qualified.
The preparation method of the collutory of other embodiment above-mentioned is with reference to embodiment 7.
Embodiment 11-15: the application of bletilla striata extract in dentifrice.
The dentifrice constitutive material of embodiment 11-15 and weight percent content are as following table:
In above-described embodiment 12; natural whiting, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium sodium are added after weighing up by formula consumption in mixing agitator to stir and add bletilla striata extract after 20 minutes and stir 10 minutes; finally add essence, sorbitol stir after 20 minutes shut down, sampling detect qualified after make.
In above-described embodiment 13; calcium phosphate dibasic dihydrate, silicon dioxide, sodium carboxymethyl cellulose, saccharin sodium sodium, sodium lauryl sulphate, nipalgin mixed ester sodium are added after weighing up by formula consumption in mixing agitator and stir after 20 minutes; add bletilla striata extract and stir 10 minutes; finally add essence, sorbitol stir after 20 minutes shut down, sampling detect qualified after make.
Embodiment 11 is with reference to executing example 12, and other embodiment, with reference to executing example 13.
Embodiment 16-20: the application of bletilla striata extract in throat lozenge.
The throat lozenge constitutive material of embodiment 16-20 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing throat lozenge production technology.
Embodiment 21-25: the application of bletilla striata extract in chewing gum.
The chewing gum constitutive material of embodiment 21-25 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing chewing gum production technology.
clinical trial part:
the anastalsis pharmacological experiment of bletilla striata extract toothpaste;
get healthy white rabbit 55, body weight 2.0 ~ 2.5kg, male and female dual-purpose.Slowly inject with 3% pentobarbital sodium 30mg/kg auricular vein, after family's rabbit anesthesia, lie on the back and be fixed on operating-table, abdominal part median incision is about 6 ~ 8cm, exposes and fixes liver, cuts liver organization be about 1cm with operating scissors at leftlobe of liver, wide about 1cm, height is 1cm about, and wound surface is hemorrhage in spraying sample.After wiping the blood of ejection, treat examination matter sample 1g at wound surface local spreading immediately, gauze is topped, to remove counterweight after the compressing of 200g counterweight 1min, 1min, observe haemostatic effect, with not hemorrhage for hemostasis, as still hemorrhage, then add spreading and continue pressurization after examination matter sample, observe once every 30s, record bleeding stopping period, as still hemorrhage more than 3min, be then designated as and fail to stop blooding, bleeding stopping period is designated as > 3min.After each sample test, wash away residual tested material with 37 DEG C of normal saline, make wound surface again hemorrhage, then test next tested material sample.Every rabbit carries out four liver local woanded surface damage hemostasis test experiments, and the drug of topical application of Latin square program pressed by each tested material sample, to reduce the impact of liver local woanded surface damage otch difference and medication order.Blank group, toothpaste bare substrate group, positive drug YUNNAN BAIYAO group, Pseudobulbus Bletillae (Rhizoma Bletillae) toothpaste sample group.Each tested material sample amounts to the hemostasis experiment carrying out 20 rabbit liver local woanded surface bleeding due to traumies.Haemostatic effect is designated as score value F by scoring method reciprocal (10/T), and more than 3min fails to stop blooding, and F is designated as 0 without score value.Record and carry out statistics t inspection, the results are shown in Table 1:
experimental result shows, Pseudobulbus Bletillae (Rhizoma Bletillae) toothpaste sample group and YUNNAN BAIYAO group all have obvious haemostatic effect to rabbit liver local woanded surface bleeding due to trauma, shows that Pseudobulbus Bletillae (Rhizoma Bletillae) toothpaste sample group and YUNNAN BAIYAO group have obvious anastalsis,
conclusion: the sample sets containing bletilla striata extract toothpaste all has obvious haemostatic effect to rabbit liver local woanded surface bleeding due to trauma, has obvious anastalsis.
Claims (5)
1. bletilla striata extract is preparing the application in toothpaste, it is characterized in that: in the technique preparing toothpaste, bletilla striata extract is added in toothpaste using the form of single medicinal material as the active component of control gingival hemorrhage, the percentage by weight of described Bletilla in total mastic of toothpaste is 1.0-10.0%, and described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
2. bletilla striata extract is preparing the application in collutory, it is characterized in that: in the technique preparing collutory, bletilla striata extract is added in collutory using the form of single medicinal material as the active component of control gingival hemorrhage, the percentage by weight of described Bletilla in collutory raw material is 1.0-10.0%, and described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
3. bletilla striata extract is preparing the application in dentifrice, it is characterized in that: in the technique preparing dentifrice, bletilla striata extract is added in dentifrice using the form of single medicinal material as the active component of control gingival hemorrhage, the percentage by weight of described Bletilla in dentifrice raw material is 1.0-10.0%, and described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
4. bletilla striata extract is preparing the application in throat lozenge, it is characterized in that: in the technique preparing throat lozenge, bletilla striata extract is added in throat lozenge using the form of single medicinal material as the active component of control gingival hemorrhage, the percentage by weight of described Bletilla in throat lozenge raw material is 1.0-10.0%, and described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
5. bletilla striata extract is preparing the application in chewing gum, it is characterized in that: in the technique preparing chewing gum, bletilla striata extract is added in chewing gum using the form of single medicinal material as the active component of control gingival hemorrhage, the percentage by weight of described Bletilla in chewing-gum material is 1.0-10.0%, and described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104013547B (en) * | 2014-05-26 | 2016-05-11 | 皖南医学院 | A kind of hemostasis brilliant white fresh breath type toothpaste and preparation method thereof |
| TWM495861U (en) * | 2014-09-10 | 2015-02-21 | Hua Niu Entpr Co Ltd | Micro-particle comprising of plectranthus amboinicus |
| CN104997701A (en) * | 2015-08-17 | 2015-10-28 | 杭州华胄科技有限公司 | Oral care product containing bletilla striata alcohol extract and having anti-Hp (helicobacter pylori) efficacy |
| CN105534805B (en) * | 2016-01-11 | 2018-10-19 | 广西大学 | A kind of Chinese herbal toothpaste of antibacterial anti hemorrhagic |
| CN106137853A (en) * | 2016-08-17 | 2016-11-23 | 林少英 | A kind of fresh breath toothpaste |
| CN106177465A (en) * | 2016-08-24 | 2016-12-07 | 成都体九生物科技有限公司 | Toothpaste containing Radix Notoginseng extract and Pseudobulbus Bletillae (Rhizoma Bletillae) extract and preparation method thereof |
| CN106511423A (en) * | 2016-12-15 | 2017-03-22 | 柳州两面针股份有限公司 | Application of annual fleabane herb extract in preparation of mouth care health product |
| CN107242993B (en) * | 2017-06-23 | 2020-07-31 | 王会海 | Spearmint enzyme mouthwash and preparation method thereof |
| CN107811941A (en) * | 2017-11-21 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | One kind shield gum toothpaste |
| CN109260125A (en) * | 2018-11-30 | 2019-01-25 | 俞傲然 | A kind of powder of brushing teeth that can effectively control bleeding gums, be good for tooth, permanent tooth |
| CN114848561A (en) * | 2022-07-07 | 2022-08-05 | 云南诺特金参口腔护理用品有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method thereof |
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| CN102133341A (en) * | 2011-03-15 | 2011-07-27 | 玉龙达通(北京)科技有限公司 | Oral cavity nursing agent, preparation method thereof and application thereof |
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| CN101380285B (en) * | 2008-09-26 | 2010-09-22 | 中华全国供销合作总社南京野生植物综合利用研究院 | Bletilla striata Chinese herbal medicine toothpaste |
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| CN102133341A (en) * | 2011-03-15 | 2011-07-27 | 玉龙达通(北京)科技有限公司 | Oral cavity nursing agent, preparation method thereof and application thereof |
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