CN102283795A - Propolis toothpaste and preparation method thereof - Google Patents

Abstract

The invention provides a propolis toothpaste and a preparation method thereof. The propolis toothpaste comprises the following raw materials in percentage by weight: 0.03 to 3.2 percent of propolis powder, 25 to 46 percent of natural calcium carbonate, 5 to 15 percent of silicon dioxide, 3 to 20 percent of glycerine, 1 to 10 percent of polyethylene glycol-400, 0.2 to 1.0 percent of sodium pyrophosphate, 0.2 to 1.5 percent of xanthan gum, 0.1 to 1.5 percent of carboxymethyl cellulose, 3 to 25 percent of sorbitol, 0.1 to 1 percent of sodium saccharin, 1 to 5 percent of sodium lauryl sulphate, 0.05 to 0.5 percent of sodium ethyl p-hydroxybenzoate, 0.02 to 2 percent of sodium propyl p-hydroxybenzoate , 0.3 to 3 percent of essence, 0.01 to 0.3 percent of triclosan, 0.05 to 2 percent of zinc citrate and the balance of water. The propolis toothpaste has a relatively good protection effect on teeth, and can nourish gingivae and prevent gingiva inflammation.

Description

A kind of bee glue tooth paste and preparation method thereof

Technical field

The present invention relates to daily use chemicals product technical field, specifically is a kind of bee glue tooth paste and preparation method thereof.

Background technology

Propolis (propolis) is that Apis is gathered plumelet of glue source plant and the resin on the trunk, the slightly bitter colloid substance of a kind of brown that mixes the secretions of its mandibular gland and form, propolis is approximately by 50% resin and the fragrant liquid of plant, 30% Cera Flava, 10% aromatic oil material, 5% pollen and 5% comprise other material composition of organ clast.Can resist the invasion and attack of external microorganism.Propolis has physiology and pharmacologically active widely, and its anti-microbial property is proved.Propolis all has the inhibition effect to gram positive bacteria, negative bacterium, fungus, virus, many scholar's research the inhibitory action of propolis to the oral cavity pathogen.

The complicated component of propolis is various, except that containing a large amount of Flavonoid substances, also contains phenols, aldehydes, alcohols, aromatic acid, fatty acid, terpenoid, mineral, vitamin etc.The multiformity of propolis composition is relevant with geographical environment, the weather conditions of Apis life, mainly is relevant with the glue source plant of gathering.The antibacterial action of propolis is relevant with its composition.The functional component of propolis antibacterial action is flavonoid and aromatic acid and the ester thereof in the resin, and galangin, Folium Pini element and pinocembrin are the flavonoids of confirming the strongest to bacterial action.

Dental caries (Dental Caries) is under the multifactor impact based on antibacterial, and the destructive a kind of disease of chronic progressive external takes place in dental hard tissue, is the most common a kind of oral disease.World Health Organization (WHO) has been listed as itself and cancer and cardiovascular disease three big diseases of harm humans health.Dental plaque is an indispensable microecological environment in the dental caries generating process.The acidic metabolite that the bacterial metabolism carbohydrate produces in the bacterial plaque can cause enamel decalcification, dissolving, and then forms dental caries.Therefore, as long as can effectively control bacterial plaque, just can effectively control the generation and the development of dental caries.Medicated toothpaste is as one of method of controlling bacterial plaque, and extensive use in the self health care measure of oral cavity is added suitable anticaries agent and be can be used as a kind of comparatively ideal preventing decayed tooth approach in toothpaste.In recent years, natural drug has become a kind of Critical policies in the new drug development as a kind of alternative of health care.Propolis can suppress the growth and the adhesion of main cariogenic bacteria as a kind of natural product with extensive pharmacological action, and can effectively control bacterial plaque formation, reduces dental caries and takes place.Propolis has no side effect according to the literature, and is safe in utilization, do not produce drug resistance.In the research about propolis, the report of bee glue tooth paste is rare at present.

Summary of the invention

The purpose of this invention is to provide a kind of bee glue tooth paste and preparation method thereof, promptly reach cleaning strong tooth, play again simultaneously and prevent and treat oral disease,, effectively control the generation and the development of dental caries by reducing plaque bacteria and producing acidity to reach the effect that the control dental caries takes place.

Technical scheme of the present invention is to add in toothpaste matrix that propolis is refining to form, and its concrete prescription is by weight percentage:

Propolis powder 0.03 ~ 3.2 %

Natural whiting 25 ~ 46% (abrasivus)

Silicon dioxide 5 ~ 15% (abrasivus)

Glycerol 3 ~ 20% (wetting agent)

Polyethylene Glycol-400 1 ~ 10% (wetting agent)

Tetrasodium pyrophosphate 0.2 ~ 1.0% (stabilizing agent)

Xanthan gum 0.2 ~ 1.5% (thickening agent)

Carboxymethyl cellulose 0.1 ~ 1.5% (stalemate agent)

Sorbitol 3 ~ 25% (wetting agent, detergent, binding agent, sweeting agent)

Saccharin sodium 0.1 ~ 1% (sweeting agent)

Sodium lauryl sulphate 1 ~ 5% (foaming agent)

Ethylparaben sodium 0.05 ~ 0.5% (antiseptic)

Soluble propylhydroxybenzoate 0.02 ~ 2% (antiseptic)

Essence 0.3 ~ 3% (fumet)

Triclosan 0.01 ~ 0.3%(antiseptic)

Zinc citrate 0.05 ~ 2% (eliminating bacterial plaque and gingivitis)

Water to 100%

Method for making:

1) it is standby as the propolis alcoholic solution earlier propolis to be dissolved in 95% ethanol;

2) tetrasodium pyrophosphate is dissolved in the glycerol, again xanthan gum is well-dispersed in the glycerol, add carboxymethyl cellulose again and be well-dispersed in the glycerol, standby;

3) saccharin sodium, ethylparaben sodium, soluble propylhydroxybenzoate is water-soluble, standby;

4) sorbitol and Polyethylene Glycol mixing is standby;

5) silicon dioxide, natural whiting, sodium lauryl sulphate and zinc citrate are mixed, standby;

6) triclosan is dissolved in essence, standby;

7) with above-mentioned 2), 3), 4), 5), 6) standby of step puts into Manufacturing medicine extract machine, in vacuum-0.09 o'clock, start at a high speed and at a slow speed scraper plate stirred 20 minutes, add 1 then) the propolis alcoholic solution of step, stir; Mastic in the Manufacturing medicine extract machine is sucked the storage pot as far as possible to be stirred once more; Sterilization, packing.

The present invention adds natural propolis in the toothpaste, by the daily control bacterial plaque of brushing teeth, possesses the dual function of chemistry and machinery control simultaneously, and the wide development prospect is arranged.Bee glue tooth paste has nourishing and protection gingiva effect, can make tooth firmer, and gingiva is more healthy, prevents oral disease comprehensively.The characteristics of bee glue tooth paste are that it has contained special propolis composition, and Here it is, and it is different from the reason of other toothpaste.Bee glue tooth paste has the better protect effect for tooth, but also can nourish gingiva, the generation of prevention of gingivitis disease.

The specific embodiment

Embodiment 1:

Propolis powder 0.03 %

Natural whiting 35% (abrasivus)

Silicon dioxide 26% (abrasivus)

Glycerol 3% (wetting agent)

Polyethylene Glycol-400 1% (wetting agent)

Tetrasodium pyrophosphate 0.2% (stabilizing agent)

Xanthan gum 0.2% (thickening agent)

Carboxymethyl cellulose 0.1% (stalemate agent)

Sorbitol 3% (wetting agent, detergent, binding agent, sweeting agent)

Saccharin sodium 0.1% (sweeting agent)

Sodium lauryl sulphate 1% (foaming agent)

Ethylparaben sodium 0.05% (antiseptic)

Soluble propylhydroxybenzoate 0.02% (antiseptic)

Essence 0.3% (fumet)

Triclosan 0.01%(antiseptic)

Zinc citrate 0.05% (eliminating bacterial plaque and gingivitis)

Water to 100%

Method for making:

1) it is standby as the propolis alcoholic solution earlier propolis to be dissolved in 95% ethanol;

2) tetrasodium pyrophosphate is dissolved in the glycerol, again xanthan gum is well-dispersed in the glycerol, add carboxymethyl cellulose again and be well-dispersed in the glycerol, standby;

3) saccharin sodium, ethylparaben sodium, soluble propylhydroxybenzoate is water-soluble, standby;

4) sorbitol and Polyethylene Glycol mixing is standby;

5) silicon dioxide, natural whiting, sodium lauryl sulphate and zinc citrate are mixed, standby;

6) triclosan is dissolved in essence, standby;

7) with above-mentioned 2), 3), 4), 5), 6) standby of step puts into Manufacturing medicine extract machine, in vacuum-0.09 o'clock, start at a high speed and at a slow speed scraper plate stirred 20 minutes, add 1 then) the propolis alcoholic solution of step, stir; Mastic in the Manufacturing medicine extract machine is sucked the storage pot as far as possible to be stirred once more; Sterilization, packing.

Embodiment 2:

Propolis powder 1.6 %

Natural whiting 20% (abrasivus)

Silica 1 0% (abrasivus)

Glycerol 10% (wetting agent)

Polyethylene Glycol-400 7% (wetting agent)

Tetrasodium pyrophosphate 0.5% (stabilizing agent)

Xanthan gum 1.2% (thickening agent)

Carboxymethyl cellulose 1.3% (stalemate agent)

Sorbitol 15% (wetting agent, detergent, binding agent, sweeting agent)

Saccharin sodium 0.8% (sweeting agent)

Sodium lauryl sulphate 3% (foaming agent)

Ethylparaben sodium 0.3% (antiseptic)

Soluble propylhydroxybenzoate 1.2% (antiseptic)

Essence 1.6% (fumet)

Triclosan 0.15%(antiseptic)

Zinc citrate 1.6% (eliminating bacterial plaque and gingivitis)

Water to 100%

Method for making is with embodiment 1.

Embodiment 3:

Propolis powder 3.2 %

Natural whiting 20% (abrasivus)

Silicon dioxide 8% (abrasivus)

Glycerol 15% (wetting agent)

Polyethylene Glycol-400 10% (wetting agent)

Tetrasodium pyrophosphate 1.0% (stabilizing agent)

Xanthan gum 1.5% (thickening agent)

Carboxymethyl cellulose 1.5% (stalemate agent)

Sorbitol 10% (wetting agent, detergent, binding agent, sweeting agent)

Saccharin sodium 1% (sweeting agent)

Sodium lauryl sulphate 5% (foaming agent)

Ethylparaben sodium 0.5% (antiseptic)

Soluble propylhydroxybenzoate 2% (antiseptic)

Essence 3% (fumet)

Triclosan 0.3%(antiseptic)

Zinc citrate 2% (eliminating bacterial plaque and gingivitis)

Water to 100%

Method for making is with embodiment 1.

The effect explanation:

1, research method

Adopt the method for completely random packet design, 40 experimenters by registration successively ordering, are divided into two groups by the table of random number method with the experimenter: experimental group and matched group at random; Test toothpaste is white pipe, is divided into No. 1 and No. 2 (wherein be blank toothpaste No. 1, No. 2 is the bee glue tooth paste of embodiment 2).

After the plaque index baseline is checked (checking for the first time), whole experimenters are carried out method for brushing teeth instruct.The experimenter uses unified toothbrush and specified toothpaste, requires to brush teeth every day 2 times (early, evening) with level vibration method, and 2min at least uses lotion of toothpaste to be degree with 1-1.5cm when brushing teeth at every turn.Require not use in the process of the test antibiotic and other any dental care products, as the toothpaste of other kinds, toothbrush, collutory, dental floss etc.Diet is not limited.

Check in 16:30-17:30 at every turn, require to check preceding two hours different fastings.The experimenter is respectively at using the 1st week behind the toothpaste, carrying out in the 4th week for the second time, check for the third time, the record plaque index.

0=does not have bacterial plaque or painted;

The visible point-like of l=neck portion, be dispersed in bacterial plaque;

The visible thin and continuous band-shaped bacterial plaque of 2=neck portion

3=neck portion bacterial plaque band is greater than lmm, but less than 1/3 of facing;

The 4=bacterial plaque covers facing and surpasses 1/3, but is no more than 2/3;

The 5=bacterial plaque covers facing and surpasses 2/3.

Check lip (cheek) face and the lingual surface of every tooth.Except that the 3rd ground one's teeth in sleep, remaining tooth was all at the row of counting.The whole tested facing gained score sum/overall measurement facing numbers of each experimenter's plaque index mean (PI)=each experimenter.Baseline, l after week, the average plaque indexs in 4 week backs are designated as PI respectively ₀, PI _l, P1 ₄, the variation of plaque index is designated as △ PI respectively after l week and 4 weeks ₁, △ PI ₄△ PIo=PIo-PIn wherein, n=l or 4.

2, result

All 40 subjects are not all found any untoward reaction at duration of test.

Use the situation of the two groups of plaque index values in toothpaste front and back to see Table 1.Adopt the variance analysis of two factor replications, the difference of analyzing two groups of subjects plaque index values does not on the whole have significance (F=0.26, P=0.6269), compare (F=648.43 at different time, P＜0.0001), the reciprocal action of grouping and time is (F=395.45, P＜0.0001) obviously.

The comparison of table 1 experimenter plaque index (

± s)

(baseline, l after week, the average plaque indexs in 4 week backs are designated as PIo, PI respectively _l, P1 ₄, bacterial plaque after l week and 4 weeks

Index variation is designated as △ PI respectively _I, △ PI ₄△ PIo=PIo-PIn wherein, n=l or 4)

Grouping	Number	PIo	PI l	P1 4
					Matched group	20	2.2569±0.3159	2.1689±0.3627	2.0569±0.3269
Experimental group	20	2.3199±0.3265	2.2663±0.3992	1.8542±0.3195

(during baseline) two groups of PI values relatively do not have significant difference (P=0.4560) before the experiment beginning, and two groups of experimental subject plaque index baseline unanimities have comparability.The two groups of PI values in 1 week back all descend to some extent, relatively do not have significant difference (P=0.5290) between group; After 4 weeks, two groups of PI values all descended to some extent than the 1st week, relatively had significant difference (P=0.0037) between group.

The comparison of table 2 experimenter plaque index situation of change (

± s)

(baseline, l after week, the average plaque indexs in 4 week backs are designated as PIo, PI respectively _l, P1 ₄, bacterial plaque after l week and 4 weeks

Index variation is designated as △ PI respectively _I, △ PI ₄△ PIo=PIo-PIn wherein, n=l or 4)

Grouping	Number	△PI I	△PI 4
				Matched group	20	0.07596±0.0296	0.1236±0.0216
Experimental group	20	0.0759±0.0269	0.4965±0.0301

As show shown in 3-2, Fig. 3-2, two groups before and after self relatively, test group the 4th all △ PI ₄With l week △ PI ₁Relatively, has significant significant difference (P＜0.0001); And matched group the 4th all △ PI ₄Value and l week △ PI ₄Relatively, there is not significant difference (P=0.8235).

Claims (2)

1. bee glue tooth paste is characterized in that the weight proportion of raw material is:

Propolis powder 0.03 ~ 3.2 %

Natural whiting 25 ~ 46%

Silicon dioxide 5 ~ 15%

Glycerol 3 ~ 20%

Polyethylene Glycol-400 1 ~ 10%

Tetrasodium pyrophosphate 0.2 ~ 1.0%

Xanthan gum 0.2 ~ 1.5%

Carboxymethyl cellulose 0.1 ~ 1.5%

Sorbitol 3 ~ 25%

Saccharin sodium 0.1 ~ 1%

Sodium lauryl sulphate 1 ~ 5%

Ethylparaben sodium 0.05 ~ 0.5%

Soluble propylhydroxybenzoate 0.02 ~ 2%

Essence 0.3 ~ 3%

Triclosan 0.01 ~ 0.3%

Zinc citrate 0.05 ~ 2%

Water surplus.

2. the preparation method of the described bee glue tooth paste of claim 1 is characterized in that carrying out according to the following steps:

1) it is standby as the propolis alcoholic solution earlier propolis to be dissolved in 95% ethanol;

2) tetrasodium pyrophosphate is dissolved in the glycerol, again xanthan gum is well-dispersed in the glycerol, add carboxymethyl cellulose again and be well-dispersed in the glycerol, standby;

3) saccharin sodium, ethylparaben sodium, soluble propylhydroxybenzoate is water-soluble, standby;

4) sorbitol and Polyethylene Glycol mixing is standby;

5) silicon dioxide, natural whiting, sodium lauryl sulphate and zinc citrate are mixed, standby;

6) triclosan is dissolved in essence, standby;

7) with above-mentioned 2), 3), 4), 5), 6) standby of step puts into Manufacturing medicine extract machine, in vacuum-0.09 o'clock, start at a high speed and at a slow speed scraper plate stirred 20 minutes, add 1 then) the propolis alcoholic solution of step, stir; Mastic in the Manufacturing medicine extract machine is sucked the storage pot as far as possible to be stirred once more; Sterilization, packing.