CN108096105A - A kind of potent hemostasis, eliminating dampness and heat toothpaste and preparation method thereof - Google Patents
A kind of potent hemostasis, eliminating dampness and heat toothpaste and preparation method thereof Download PDFInfo
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- CN108096105A CN108096105A CN201810012427.1A CN201810012427A CN108096105A CN 108096105 A CN108096105 A CN 108096105A CN 201810012427 A CN201810012427 A CN 201810012427A CN 108096105 A CN108096105 A CN 108096105A
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- toothpaste
- heat
- hemostasis
- eliminating dampness
- solubilizer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Microbiology (AREA)
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- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of potent hemostasis, eliminating dampness and heat toothpaste and preparation method thereof, and the toothpaste is made of the component of following mass fraction：Sorbierite 1~10%, CMC0.5~2%, sweetener 0.05~1%, foaming agent 1~5%, rubbing agent 30~70%, preservative 0.1~0.5%, ethyl alcohol 1~10%, penetrating agent 0.2~1%, solubilizer 1~5%, PEG0~5%, fluoride 0~0.15%, essence 0~2%, Japan cypress oil 1~2%, surplus are water；Wherein, the penetrating agent is Laurocapram and the mixture of menthol, and the mass ratio of the Laurocapram, menthol and Japan cypress oil is 0.2~0.3：0.05~0.1：1~2；The solubilizer is one or more of alkyl glycosides, tween or Crodaret.The compounding that the present invention passes through Laurocapram, menthol and Japan cypress oil, it is aided with specific solubilizer and other auxiliary materials, the irritation for the toothpaste being prepared is small, and hemostasis, hemoglutination and bacteriostasis are strong, and long-time service has many advantages, such as to prevent gum, oral hemorrhage, pre- ulcer；And Nantural non-toxic is done harm to, and civilian, public place is suitble to widely use.
Description
Technical field
The present invention relates to synthetic detergent technical fields, and in particular, to a kind of potent hemostasis, eliminating dampness and heat toothpaste and its
Preparation method.
Background technology
It is improved simultaneously as people clean requirement, assigns more both effectiveness oral-cavity cleaning products and continuously emerge, due to people
Diet pungent, the food and drink that cools contact, mucous membrane of mouth, gum position nagiopasthyrosis, film is caused to be damaged, produce
Blood is born, affects oral cavity safety.Some brand products are commonly incorporated into Chinese medicine, western medicine composition to improve bleeding, but are limited to
Oral cavity, gum, tooth incomplete absorption, anastalsis are unsatisfactory.
Therefore, research and develop it is a it is pure natural, it is safe efficient inhibit bleeding, hemostasis mouth rinse products become industry there is an urgent need for
It solves the problems, such as.
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of potent hemostasis, eliminating dampness and heat toothpaste, this hairs
The bright compounding by Laurocapram, menthol and Japan cypress oil is aided with specific solubilizer and other auxiliary materials, the tooth being prepared
The irritation of cream is small, and hemostasis, hemoglutination and bacteriostasis are strong；And Nantural non-toxic is done harm to, and civilian, public place is suitble to make extensively
With.
Another object of the present invention is to provide the preparation method of above-mentioned potent hemostasis, eliminating dampness and heat toothpaste.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of potent hemostasis, eliminating dampness and heat toothpaste, the toothpaste are made of the component of following mass fraction：
It is sorbierite 1~10%, CMC 0.5~2%, sweetener 0.05~1%, foaming agent 1~5%, rubbing agent 30~70%, anti-
Rotten agent 0.1~0.5%, ethyl alcohol 1~10%, penetrating agent 0.2~1%, solubilizer 1~5%, PEG 0~5%, fluoride 0~
0.15%th, essence 0~2%, Japan cypress oil 1~2%, surplus are water；
Wherein, the penetrating agent is Laurocapram and the mixture of menthol, and the Laurocapram, menthol and Japan cypress are oily
Mass ratio be 0.2~0.3：0.05~0.1：1~2；The solubilizer is alkyl glycosides, tween or polyethylene glycol hydrogenated castor-oil plant
One or more of oil.
The present inventor attempt to prepare it is a kind of with it is potent stop blooding, the toothpaste of eliminating dampness and heat when, find natural side
CedarLeaves have effects that preferably hemostasis, blood coagulation, but its there are powder state active constituent content is low, universal transparent system can not
The problems such as use.Inventor has found after numerous trials, Japan cypress oil（Cedar oil）Active ingredient such as Quercetin and tannin contain
The features such as amount is high, transparent and oil-soluble makes it possess the effect of good hemostasis, blood coagulation and eliminating dampness and heat, and to golden yellow
The pathogens such as staphylococcus, bacillus anthracis have stronger antimicrbial power.Higher percutaneous absorbtion rate how is generated, is made in Japan cypress oil
Active ingredient is more fully absorbed by the body, more crucial so as to efficiently play hemostasis, blood coagulation and eliminating dampness and heat effect.
Menthol is irritating to the skin effect, can slowly penetrate intracutaneous, causes prolonged hyperemia, and reflectivity causes depth
Portion's Vascular change adjusts vascular function, and reaches osmotic absorption effect；Also anti-inflammatory, analgesic effect simultaneously.Laurocapram is
Nonpolar scalp accelerating agent, it can make cutin softening, enhance permeability, make drugs through skin barrier, improve locally or systemically
Blood concentration improves preparation bioavilability, has transdermal facilitation to lipophilicity hydrophilic medicament, and toxicity is low.
Inventor has found to possess partial hemostasis in use using toothpaste prepared by menthol, Japan cypress oil in an experiment, coagulate
Blood effect has preferable hemostasis hemoglutination using the toothpaste of Laurocapram, Japan cypress oil in short-term test, but stimulates
Property increase, empirical tests are found this is because foaming agent, preservative in toothpaste cause to inhale by the rush effect of oozing of Laurocapram
It receives and excessively generates stimulate the reaction.It is found after inventor's repetition test, when the mass ratio of Laurocapram, menthol and Japan cypress oil
For 0.2~0.3：0.05~0.1：When 1~2, irritation is minimum, and hemostasis, hemoglutination are best.This may be because：Peppermint
Alcohol stimulates nerve endings receptor to generate cold sensation first, and oil-soluble carries Japan cypress oil and slowly penetrates intracutaneous, and reflects and draws
Deep vessels variation is played, vascular function is adjusted, oozes therapeutic effect so as to reach rush, and its anti-inflammatory, analgesic effect reduce tooth
The irritation of cream.And Laurocapram is playing cutin-softening layer, when increasing permeability effect, makees with the activating vessels of menthol
With working simultaneously, therefore the synergistic rush effect of oozing is generated, while reduce the usage amount in irritation source, more efficient rush
The active ingredient of Japan cypress oil is absorbed into skin.
In addition, it is found after inventor's experiment, alkyl glycosides（C8-14APG）, tween (Twen80), polyethylene glycol hydrogenated castor
Sesame oil（RH40）Preferable for Japan cypress oil, menthol, the emulsification of Laurocapram, solubilising power, product clear homogeneous is stablized.Cause
This, the present invention selects one or more of alkyl glycosides, tween or Crodaret to be used as solubilizer.
Preferably, the Japan cypress oil is natural extraction Cypress ethereal oil.
For oral cavity and the architectural characteristic of skin and mucosa, surfactant except be directed to oil phase active ingredient possess solubilising,
Outside emulsification, it is also necessary to there are the performances such as surface tension, preferable wetability relatively low in aqueous solution, therefore for different tables
The emulsion of face activating agent（The aqueous surfactant solution of the solubilized Japan cypress oil of emulsification）It has been relevant comparative.It is multiple by inventor
It is found after trial, using Crodaret（RH40）And alkyl glycosides（C8-14APG）Compounding, solution surface
Power reduces more, the imparting stronger wettability of product, and has for menthol, Japan cypress oil, the solubilising power of Laurocapram
It significantly improves.RH40：C8-14APG=1：1~1：When 2, effect synergy is apparent, toothpaste 10% aqueous solution surface tension after dilution
Up to 31.7mN/m, imparting toothpaste active ingredient better wettability on oral cavity, tooth, gum is cell through penetrating agent
Effect absorbs Japan cypress oil and provides better power-assisted；Compounding provides stronger solubilising power, assigns object hard to tolerate in formulation of tooth-paste（Oil is molten
Japan cypress oil, menthol, Laurocapram）Better Investigation of stabilized dispersion of nano.Therefore, it is further preferable that the solubilizer is alkyl sugar
Glycosides（C8-14APG）And Crodaret（RH40）Compounding.
Preferably, the toothpaste is made of the component of following mass fraction：
Sorbierite 1~10%, CMC 0.5~1.5%, sweetener 0.05~1%, foaming agent 1~3%, rubbing agent 30~50%,
Preservative 0.1~0.5%, ethyl alcohol 1~3%, penetrating agent 0.2~0.5%, solubilizer 1~3%, PEG 2~5%, fluoride 0~
0.15%th, essence 0~1%, Japan cypress oil 1~2%, surplus are water.
Preferably, glued during CMC is or height glues sodium carboxymethylcellulose.
Preferably, the sweetener is the one or more of saccharin sodium, chlorinated sucrose or xylitol；The rubbing agent is carbon
Sour calcium and/or silica；The preservative is potassium sorbate, Buddhist nun moors fourth methyl esters or Buddhist nun moors the one or more of fourth propyl ester.
Preferably, the foaming agent is lauryl sodium sulfate；The fluoride is food-grade sodium fluoride or single fluorophosphoric acid
Sodium.
In the present invention, each raw material is food grade materials.
The present invention protects above-mentioned potent hemostasis, the preparation method of eliminating dampness and heat toothpaste simultaneously, and the method is as follows：
S1：Ethyl alcohol, Japan cypress oil, menthol and Laurocapram are uniformly mixed；
S2：Sorbierite and CMC are added water-swellable；
S3：Add water, S1 gained pre-compositions and other materials to swelling solution obtained by S2, stir evenly, grind, deaerate up to described strong
Effect hemostasis, eliminating dampness and heat toothpaste.
Compared with prior art, the present invention has the advantages that：
The present invention by using Laurocapram, menthol as compounding penetrating agent, have increase Skin Cell infiltration, promote it is flat
Pitch absorbs, while the advantages that reduce irritation；The present invention use Japan cypress oil for natural extract, with hemostasis, blood coagulation, clearly
The effects that dampness removing is warm, and its good oil-soluble, active ingredient are high, are suitble to a variety of cleaning systems.The present invention selects specific
Solubilizer cause toothpaste have relatively low surface tension, wettability is good, this cause Japan cypress oil be more easy to mucous membrane of mouth, gum,
Tooth complicated interface uniformly disperses, and to play potent hemostasis, hemoglutination provides support；In addition, in the natural extraction of efficient solubilising
While the molten active ingredient of oil such as object, the good stability of formula system is additionally provided.
The present invention is aided with specific solubilizer and other auxiliary materials by the compounding of Laurocapram, menthol and Japan cypress oil,
The irritation for the toothpaste being prepared is small, and hemostasis, hemoglutination and bacteriostasis are strong.And Nantural non-toxic is done harm to, and is suitble to civilian, public
Place widely uses altogether.
Specific embodiment
Further illustrated the present invention below in conjunction with specific embodiment, but embodiment the present invention is not done it is any type of
It limits.Unless stated otherwise, the reagent of the invention used, method and apparatus for the art conventional reagent, method and are set
It is standby.
Unless stated otherwise, agents useful for same and material of the present invention are purchased in market.
Primary raw material information is as follows：
Sorbierite, ethyl alcohol, CMC, sweetener, foaming agent, essence, preservative；It is commercially available；
Laurocapram；Purchased from Kaifeng world high-tech chemical technology Co., Ltd, content 99%；
Menthol；Purchased from the medicinal hundred Cao You refineries in Jiangxi Province Jishui County water south, content 99.8%；
Alkyl glycosides C8-14；Purchased from Shanghai Fakai Chemical Co., Ltd., content 50%；
Polyoxyethylene ether rilanit special；Purchased from German BASF.
Examples 1 to 6 and a kind of potent hemostasis of comparative example 1~4, eliminating dampness and heat toothpaste
The formulation of tooth-paste that 1 Examples 1 to 6 of table and comparative example 1~4 provide（wt%）
Performance test
Toothpaste correlated performance is detected by the following method made from the embodiment of the present invention and comparative example：
1st, 10% dentifrice liquid surface tension detection foundation《The measure of GB/T 22237-2008 surfactant surface tension》's
Relevant provision detection method is detected.
Surface tension is lower, represents toothpaste and preferably soaks in mucous membrane of mouth, gum, dental interface, applies exhibition, absorption.
2nd, using the crowd of the easy bleeding of oral cavity gum after the use of one week, then there is gum in hemostasis, coagulating effectiveness
The phenomenon that bleeding.
There is oral cavity again in nothing, bleeding gums are qualification, and it is unqualified bleeding occur
3rd, stability, according to Detection of Stability method in GB 8772-2008, using -8 degrees Celsius of refrigerators store 8 it is small when, take out
Place 45 baking ovens 8 it is small when, recover room temperature, high body without layering, be precipitated, be inverted no liquid and ooze.
4th, irritation, optional 10 people, using the experiment of brushing teeth of corresponding tooth paste product progress one week, 2 people and more than number go out
Now stimulate, itch, the impression of uncomfortable state be it is unqualified, it is opposite for qualification.
The performance test data of tooth paste product made from 2 Examples 1 to 6 of table and comparative example 1~4
。
Laurocapram is not added in comparative example 1 it can be seen from the experimental data in upper table 2, i.e. penetrating agent only has thin
Lotus alcohol, the osmosis for the toothpaste that comparative example 1 is prepared is poor, causes Japan cypress oil active ingredient cannot be by oral cavity, gum, tooth
Fully absorb, thus stop blooding, coagulating effectiveness it is poor.Menthol is not added in comparative example 2, although Laurocapram imparts preferably
Percutaneous to promote oozing effect, but the missing of menthol reduces the effect of oozing of part rush, the stimulation nerve endings of menthol uniqueness is so as to producing
Raw anti-inflammatory, the disappearance of analgesic effect so that toothpaste irritation increases.The additive amount of solubilizer is less in comparative example 3, this causes tooth
The precipitation of Japan cypress oil component in cream, cause active ingredient cannot spreading out with toothpaste, can not uniformly discharge, therefore hemostasia effect
It disappears.Comparative example 4 is commercial toothpastes, is wherein not added with any solubilizer, penetrating agent, and no hemostasis, blood coagulation, eliminating dampness and heat act on.
Can be seen that toothpaste produced by the present invention from the test result of various embodiments above has compounding penetrating agent technology,
Efficient absorption of the Skin Cell to Japan cypress oil active ingredient is effectively increased, enhances the hemostasis, blood coagulation, eliminating dampness and heat of toothpaste
Effect, while reduce irritation.Using compounding solubilizer technology, oil-soluble penetrating agent, Japan cypress olein oil component are preferably improved
Being stabilized in toothpaste assigns product toothpaste in dilution in use, possessing relatively low surface tension, makes active ingredient（Oil
Dissolubility）Penetrating agent, Japan cypress oil are synergy product hemostasis, solidifying in oral cavity, the homodisperse of gum position, absorption, percutaneous absorbtion
Blood, eliminating dampness and heat effect.
Above-described specific embodiment has carried out the purpose of the present invention, technical solution and advantageous effect further
It is described in detail, it should be understood that the foregoing is merely the specific embodiments of the present invention, is not intended to limit the present invention
Protection domain, within the spirit and principles of the invention, any modification, equivalent substitution, improvement and etc. done should all include
Within protection scope of the present invention.
Claims (8)
1. a kind of potent hemostasis, eliminating dampness and heat toothpaste, which is characterized in that the toothpaste is made of the component of following mass fraction：
It is sorbierite 1~10%, CMC 0.5~2%, sweetener 0.05~1%, foaming agent 1~5%, rubbing agent 30~70%, anti-
Rotten agent 0.1~0.5%, ethyl alcohol 1~10%, penetrating agent 0.2~1%, solubilizer 1~5%, PEG 0~5%, fluoride 0~
0.15%th, essence 0~2%, Japan cypress oil 1~2%, surplus are water；
Wherein, the penetrating agent is Laurocapram and the mixture of menthol, and the Laurocapram, menthol and Japan cypress are oily
Mass ratio be 0.2~0.3：0.05~0.1：1~2；The solubilizer is alkyl glycosides, tween or polyethylene glycol hydrogenated castor-oil plant
One or more of oil.
2. potent hemostasis, eliminating dampness and heat toothpaste according to claim 1, which is characterized in that the Japan cypress oil is natural extraction
Cypress ethereal oil.
3. potent hemostasis, eliminating dampness and heat toothpaste according to claim 1, which is characterized in that the solubilizer is by polyoxyethylene
Rilanit special and alkyl glycosides are 1 in mass ratio：1~2 ratio composition.
4. potent hemostasis, eliminating dampness and heat toothpaste according to claim 1, which is characterized in that the toothpaste is by following quality point
Several component compositions：
Sorbierite 1~10%, CMC 0.5~1.5%, sweetener 0.05~1%, foaming agent 1~3%, rubbing agent 30~50%,
Preservative 0.1~0.5%, ethyl alcohol 1~3%, penetrating agent 0.2~0.5%, solubilizer 1~3%, PEG 2~5%, fluoride 0~
0.15%th, essence 0~1%, Japan cypress oil 1~2%, surplus are water.
5. potent hemostasis, eliminating dampness and heat toothpaste according to claim 1, which is characterized in that CMC is glued in being or high viscous carboxymethyl
Sodium cellulosate；The sweetener is the one or more of saccharin sodium, chlorinated sucrose or xylitol；The rubbing agent is calcium carbonate
And/or silica；The preservative is potassium sorbate, Buddhist nun moors fourth methyl esters or Buddhist nun moors the one or more of fourth propyl ester.
6. potent hemostasis, eliminating dampness and heat toothpaste according to claim 1, which is characterized in that the foaming agent is dodecyl
Sodium sulphate；The fluoride is food-grade sodium fluoride or sodium monofluorophosphate.
7. according to claim 1 it is potent hemostasis, eliminating dampness and heat toothpaste, which is characterized in that the solubilizer for alkyl glycosides,
The one or more of tween or Crodaret.
8. any potent hemostasis of claim 1~7, the preparation method of eliminating dampness and heat toothpaste, which is characterized in that the method
It is as follows：
S1：Ethyl alcohol, Japan cypress oil, menthol and Laurocapram are uniformly mixed；
S2：Sorbierite and CMC are added water-swellable；
S3：Add water, S1 gained pre-compositions and other materials to swelling solution obtained by S2, stir evenly, grind, deaerate up to described strong
Effect hemostasis, eliminating dampness and heat toothpaste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810012427.1A CN108096105B (en) | 2018-01-05 | 2018-01-05 | Toothpaste capable of stopping bleeding, clearing damp-heat and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810012427.1A CN108096105B (en) | 2018-01-05 | 2018-01-05 | Toothpaste capable of stopping bleeding, clearing damp-heat and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN108096105A true CN108096105A (en) | 2018-06-01 |
| CN108096105B CN108096105B (en) | 2021-02-26 |
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| CN201810012427.1A Active CN108096105B (en) | 2018-01-05 | 2018-01-05 | Toothpaste capable of stopping bleeding, clearing damp-heat and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108771463A (en) * | 2018-07-06 | 2018-11-09 | 刘丽华 | A kind of preparation method of environmentally protective no-smoke incense |
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|---|---|---|---|---|
| CN102283795A (en) * | 2011-08-22 | 2011-12-21 | 昆明振华制药厂有限公司 | Propolis toothpaste and preparation method thereof |
| KR20170139997A (en) * | 2016-06-10 | 2017-12-20 | (주)라파프로폴리스 | A toothpaste composition without bubbles, and the toothpaste manufactured with the composition |
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2018
- 2018-01-05 CN CN201810012427.1A patent/CN108096105B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283795A (en) * | 2011-08-22 | 2011-12-21 | 昆明振华制药厂有限公司 | Propolis toothpaste and preparation method thereof |
| KR20170139997A (en) * | 2016-06-10 | 2017-12-20 | (주)라파프로폴리스 | A toothpaste composition without bubbles, and the toothpaste manufactured with the composition |
Non-Patent Citations (3)
| Title |
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| 姚日生 等: "《药用高分子材料》", 31 August 2003, 化学工业出版社 * |
| 平其能 等: "《药用辅料应用指南》", 31 August 2011, 中国医药科技出版社 * |
| 高茜 等: ""侧柏叶的挥发性成分分析"", 《化学研究与应用》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108771463A (en) * | 2018-07-06 | 2018-11-09 | 刘丽华 | A kind of preparation method of environmentally protective no-smoke incense |
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| CN108096105B (en) | 2021-02-26 |
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