CN108096105B - Toothpaste capable of stopping bleeding, clearing damp-heat and preparation method thereof - Google Patents

Abstract

The invention relates to a toothpaste for stopping bleeding, clearing damp heat and a preparation method thereof, wherein the toothpaste comprises the following components in parts by mass: 1-10% of sorbitol, 0.5-2% of CMC, 0.05-1% of sweetening agent, 1-5% of foaming agent, 30-70% of friction agent, 0.1-0.5% of preservative, 1-10% of ethanol, 0.2-1% of penetration enhancer, 1-5% of solubilizer, 0-5% of PEG, 0-0.15% of fluoride, 0-2% of essence, 1-2% of cypress oil and the balance of water; the penetration enhancer is a mixture of laurocapram and menthol, and the mass ratio of the laurocapram to the menthol to the hinokitiol is 0.2-0.3: 0.05-0.1: 1-2; the solubilizer is one or more of alkyl glycoside, tween or polyoxyethylene hydrogenated castor oil. According to the invention, by compounding laurocapram, menthol and hinoki oil and adding a specific solubilizer and other auxiliary materials, the prepared toothpaste has small irritation and strong hemostatic and blood coagulation effects and bacteriostatic ability, and has the advantages of preventing gum and oral bleeding, preventing ulcer and the like after long-term use; and is natural and non-toxic, and is suitable for wide application in civil and public places.

Description

Toothpaste capable of stopping bleeding, clearing damp-heat and preparation method thereof

Technical Field

The invention relates to the technical field of synthetic detergents, in particular to a toothpaste capable of stopping bleeding, clearing heat and dampness and a preparation method thereof.

Background

With the improvement of cleaning requirements of people, oral cleaning products endowed with more efficacies are continuously generated, and because of the contact of spicy and cold food and beverages in daily diet, blood vessels at oral mucosa and gum parts are fragile, films are damaged, bleeding is generated, and the oral safety is influenced. Some brands of products are often added with traditional Chinese medicine and western medicine components to improve bleeding, but are limited by insufficient absorption of oral cavity, gum and teeth, and the hemostatic effect is not ideal.

Therefore, the research and development of a pure natural, safe and efficient oral cavity cleaning product for inhibiting bleeding and stopping bleeding becomes an urgent problem to be solved in the industry.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides the toothpaste for stopping bleeding and clearing damp-heat, the toothpaste prepared by compounding laurocapram, menthol and hinokitiol and adding a specific solubilizer and other auxiliary materials is low in irritation and strong in hemostatic, blood coagulation and bacteriostatic ability; and is natural and non-toxic, and is suitable for wide application in civil and public places.

The invention also aims to provide a preparation method of the toothpaste for stopping bleeding and clearing damp-heat.

In order to achieve the purpose, the invention adopts the following technical scheme:

the toothpaste capable of stopping bleeding and clearing damp-heat is composed of the following components in parts by mass:

1-10% of sorbitol, 0.5-2% of CMC, 0.05-1% of sweetening agent, 1-5% of foaming agent, 30-70% of friction agent, 0.1-0.5% of preservative, 1-10% of ethanol, 0.2-1% of penetration enhancer, 1-5% of solubilizer, 0-5% of PEG, 0-0.15% of fluoride, 0-2% of essence, 1-2% of cypress oil and the balance of water;

the penetration enhancer is a mixture of laurocapram and menthol, and the mass ratio of the laurocapram to the menthol to the hinokitiol is 0.2-0.3: 0.05-0.1: 1-2; the solubilizer is one or more of alkyl glycoside, tween or polyoxyethylene hydrogenated castor oil.

The inventor of the invention finds that the natural cacumen biotae has good effects of stopping bleeding and coagulating blood when trying to prepare the toothpaste with the effects of stopping bleeding and clearing damp and heat, but the problems of low content of effective components in a powder state, incapability of using a universal transparent system and the like exist. After a plurality of attempts, the inventor finds that the effective components of hinoki oil (cedar oil), such as quercetin and tannin, have high contents, are transparent, have oil solubility and the like, so that the hinoki oil has good effects of stopping bleeding, coagulating blood and clearing damp-heat, and has strong antibacterial power on pathogenic bacteria such as staphylococcus aureus, bacillus anthracis and the like. How to generate higher percutaneous absorption rate, the effective components in the hinoki oil are more fully absorbed by human body, thereby playing the key role in efficiently stopping bleeding, coagulating blood and clearing damp-heat.

Menthol has stimulating effect on skin, can slowly penetrate into skin to cause long-time congestion, and reflexively causes deep blood vessel change to adjust blood vessel function to achieve the effect of penetration and absorption; it also has antiinflammatory and analgesic effects. Laurocapram is a nonpolar scalp promoter, and has effects of softening cutin, enhancing permeability, making medicine penetrate skin barrier, increasing local or systemic blood concentration, improving bioavailability of preparation, promoting transdermal effect on lipophilic and hydrophilic medicine, and low toxicity.

The inventor finds that the toothpaste prepared from menthol and hinoki oil has partial hemostasis and coagulation effects in use, and the toothpaste prepared from laurocapram and hinoki oil has better hemostasis and coagulation effects in a short-term test, but has increased irritation, and the experiment finds that the irritation is caused by excessive absorption due to the permeation promotion effect of the laurocapram and foaming agent and preservative in the toothpaste. After repeated experiments, the inventor finds that when the mass ratio of the laurocapram to the menthol to the hinokitiol is 0.2-0.3: 0.05-0.1: 1-2 hours, it has minimal irritation and good hemostatic and blood coagulation effects. This may be because: menthol stimulates nerve ending receptors to firstly generate cold feeling, oil-soluble hinoki oil of the menthol slowly penetrates into the skin and reflects to cause deep vascular change and adjust the vascular function, thereby achieving the effect of penetration promotion treatment, and the anti-inflammatory and analgesic effects of the menthol reduce the irritation of toothpaste. And when the laurocapram plays a role in softening the horny layer and increasing the permeability, the laurocapram and the function of activating blood vessels of menthol take effect simultaneously, so that a synergistic permeation promoting effect is generated, the using amount of an irritant source is reduced, and the skin is promoted to absorb the effective components of the hinokitiol more efficiently.

In addition, after the test of the inventor, the alkyl glycoside (C8-14 APG), the Tween (Twen80) and the polyoxyethylene hydrogenated castor oil (RH 40) have better emulsifying and solubilizing capabilities for hinoki oil, menthol and laurocapram, and the product is transparent, uniform and stable. Therefore, one or more of alkyl glycoside, tween or polyoxyethylene hydrogenated castor oil is/are selected as the solubilizer.

Preferably, the hinoki oil is a natural extracted cypress essential oil.

Aiming at the structural characteristics of oral cavity and skin mucosa, the surfactant has solubilization and emulsification effects on the effective components of the oil phase, and also needs to have the performances of lower surface tension, better wettability and the like in an aqueous solution, so that the emulsion of different surfactants (the surfactant aqueous solution for emulsifying and solubilizing the hinoki oil) is subjected to relevant comparison. After a plurality of attempts by the inventor, the inventor finds that the surface tension of the solution is reduced more by compounding the polyoxyethylene hydrogenated castor oil (RH 40) and the alkyl glycoside (C8-14 APG), the product is endowed with stronger wetting performance, and the solubilizing abilities of menthol, hinoki oil and laurocapram are obviously improved. RH 40: c8-14APG = 1: 1-1: 2, the effect is obviously enhanced, the surface tension of a 10% aqueous solution of the toothpaste after dilution can reach 31.7mN/m, the effective components of the toothpaste are endowed with better wetting performance on oral cavities, teeth and gum, and better assistance is provided for cells to absorb hinoki oil through the action of a penetration enhancer; the compound provides stronger solubilizing capability, and endows the difficult-to-dissolve substances (oil-soluble hinoki oil, menthol and laurocapram) in the toothpaste formula with better stable dispersibility. Therefore, more preferably, the solubilizer is a combination of alkyl glycoside (C8-14 APG) and polyoxyethylene hydrogenated castor oil (RH 40).

Preferably, the toothpaste comprises the following components in parts by mass:

1-10% of sorbitol, 0.5-1.5% of CMC, 0.05-1% of sweetening agent, 1-3% of foaming agent, 30-50% of friction agent, 0.1-0.5% of preservative, 1-3% of ethanol, 0.2-0.5% of penetration enhancer, 1-3% of solubilizer, 2-5% of PEG, 0-0.15% of fluoride, 0-1% of essence, 1-2% of hinoki oil and the balance of water.

Preferably, the CMC is medium or high viscosity sodium carboxymethyl cellulose.

Preferably, the sweetener is one or more of saccharin sodium, sucrose chloride or xylitol; the abrasive is calcium carbonate and/or silicon dioxide; the preservative is one or more of potassium sorbate, methyl paraben or propyl paraben.

Preferably, the foaming agent is sodium lauryl sulfate; the fluoride is food-grade sodium fluoride or sodium monofluorophosphate.

In the invention, all the raw materials are food-grade raw materials.

The invention also provides a preparation method of the toothpaste for stopping bleeding and clearing damp-heat, which comprises the following steps:

s1: mixing ethanol, hinokitiol, menthol and laurocapram uniformly;

s2: adding water to swell sorbitol and CMC;

s3: and adding water, the premix obtained in the step S1 and other materials into the swelling solution obtained in the step S2, uniformly stirring, grinding and degassing to obtain the toothpaste for stopping bleeding and clearing damp-heat.

Compared with the prior art, the invention has the following beneficial effects:

by adopting laurocapram and menthol as the compound penetration enhancer, the invention has the advantages of increasing skin cell penetration, promoting hinokitiol absorption, reducing irritation and the like; the hinoki oil adopted by the invention is a pure natural extract, has the effects of stopping bleeding, coagulating blood, clearing away damp and heat and the like, has good oil solubility and high effective component content, and is suitable for various cleaning systems. The toothpaste has lower surface tension and good wettability by selecting the specific solubilizer, so that the hinoki oil is more easily and uniformly dispersed on the complex interfaces of oral mucosa, gum and teeth, and provides support for playing the roles of hemostasis and blood coagulation; in addition, the oil soluble active ingredients such as natural extracts are efficiently solubilized, and meanwhile, the good stability of a formula system is provided.

According to the invention, by compounding laurocapram, menthol and hinoki oil and adding a specific solubilizer and other auxiliary materials, the prepared toothpaste has low irritation and strong hemostatic, blood coagulation and bacteriostatic abilities. And is natural and non-toxic, and is suitable for wide application in civil and public places.

Detailed Description

The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.

Unless otherwise indicated, reagents and materials used in the present invention are commercially available.

The main raw material information is as follows:

sorbitol, ethanol, CMC, sweetening agent, foaming agent, essence and preservative; is sold on the market;

laurocapram; purchased from open seal Tiandi high-tech chemical technology, Inc., with a content of 99%;

menthol; purchased from Baicao oil refinery for Shuiyan in Jishui county of Jiangxi, with a content of 99.8%;

alkyl glycoside C8-14; purchased from Shanghai Kai chemical Co., Ltd, with a content of 50%;

polyoxyethylene ether hydrogenated castor oil; purchased from basf, germany.

Examples 1-6 and comparative examples 1-4 toothpaste for stopping bleeding, clearing away damp-heat

Table 1 toothpaste formulations (wt%) provided in examples 1-6 and comparative examples 1-4

Performance testing

The toothpaste prepared by the embodiment and the comparative example of the invention is detected by the following method:

1. the surface tension detection of the 10% toothpaste liquid is carried out according to a related clause detection method of GB/T22237-2008 surface tension determination of the surfactant.

The lower the surface tension, the better the toothpaste moistens, spreads and adsorbs on the oral mucosa, gum and tooth interface.

2. The hemostatic and blood coagulation effects are achieved, and the gingival bleeding phenomenon appears after the oral cavity and gingival bleeding prone people use the oral cavity and gingival bleeding prone people for a week.

The bleeding of the oral cavity and the gum is qualified and the bleeding is unqualified

3. And (3) stability, according to a stability detection method in GB 8772 + 2008, storing for 8 hours by adopting a refrigerator at-8 ℃, taking out and placing in a 45-degree oven for 8 hours, recovering the room temperature, wherein the high body has no layering and precipitation, and no liquid drips when inverted.

4. The irritation, optionally 10 persons, is selected, and the corresponding toothpaste product is used for carrying out the tooth brushing test for one week, and the condition that 2 persons or more suffer from irritation, itching and discomfort is unqualified, and the condition is qualified on the contrary.

TABLE 2 Performance test data for toothpaste products made in examples 1-6 and comparative examples 1-4

。

As can be seen from the experimental data in the above table 2, the laurocapram is not added in the comparative example 1, namely the penetration enhancer is only menthol, and the toothpaste prepared in the comparative example 1 has poor penetration effect, so that the effective components of the hinoki oil cannot be fully absorbed by the oral cavity, the gum and the teeth, and the hemostatic and blood coagulation effects are poor. In comparative example 2, menthol was not added, and although laurocapram imparted a good transdermal penetration enhancing effect, partial penetration enhancing effect was weakened by the absence of menthol, and the unique stimulation of menthol to nerve endings resulted in the disappearance of the anti-inflammatory and analgesic effects, resulting in increased toothpaste irritation. The addition amount of the solubilizer in comparative example 3 was small, which resulted in precipitation of hinoki component in the toothpaste, causing the effective components not to be uniformly released with spreading of the toothpaste, and thus the hemostatic effect disappeared. Comparative example 4 is a commercial toothpaste without any solubilizer or penetration enhancer, and has no hemostatic, blood coagulation, dampness and heat clearing effects.

The test results of the above embodiments show that the toothpaste prepared by the invention has the compound penetration enhancer technology, effectively increases the efficient absorption of skin cells to the effective components of hinoki oil, strengthens the effects of stopping bleeding, coagulating blood, clearing damp and heat of the toothpaste, and reduces the irritation. By adopting the compound solubilizer technology, the stable existence of the oil-soluble penetration enhancer and the hinoki essential oil in the toothpaste is better improved, the toothpaste product has lower surface tension when being diluted for use, so that the effective components (oil-soluble) penetration enhancer and the hinoki oil are uniformly dispersed, adsorbed and absorbed by skin at the oral cavity and gum positions, and the effects of hemostasis, blood coagulation and clearing damp and heat of the product are enhanced.

The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (7)

1. The toothpaste for stopping bleeding and clearing damp-heat is characterized by comprising the following components in parts by mass:

1-10% of sorbitol, 0.5-2% of CMC, 0.05-1% of sweetening agent, 1-5% of foaming agent, 30-70% of friction agent, 0.1-0.5% of preservative, 1-10% of ethanol, 0.2-1% of penetration enhancer, 1-5% of solubilizer, 0-5% of PEG, 0-0.15% of fluoride, 0-2% of essence, 1-2% of cypress oil and the balance of water;

the penetration enhancer is a mixture of laurocapram and menthol, and the mass ratio of the laurocapram to the menthol to the hinokitiol is 0.2-0.3: 0.05-0.1: 1-2; the solubilizer is one or more of alkyl glycoside, tween or polyoxyethylene hydrogenated castor oil.

2. The toothpaste for stopping bleeding and clearing away damp-heat according to claim 1, wherein the hinoki oil is a natural extracted cypress essential oil.

3. The toothpaste for stopping bleeding and clearing away damp-heat according to claim 1, wherein the solubilizer is prepared from polyoxyethylene hydrogenated castor oil and alkyl glycoside in a mass ratio of 1: 1-2.

4. The hemostatic, damp-heat clearing toothpaste according to claim 1, wherein the toothpaste comprises the following components by mass:

1-10% of sorbitol, 0.5-1.5% of CMC, 0.05-1% of sweetening agent, 1-3% of foaming agent, 30-50% of friction agent, 0.1-0.5% of preservative, 1-3% of ethanol, 0.2-0.5% of penetration enhancer, 1-3% of solubilizer, 2-5% of PEG, 0-0.15% of fluoride, 0-1% of essence, 1-2% of hinoki oil and the balance of water.

5. The toothpaste for stopping bleeding, clearing away heat and dampness according to claim 1, wherein the CMC is a medium-or high-viscosity sodium carboxymethyl cellulose; the sweetening agent is one or more of saccharin sodium, chlorinated sucrose or xylitol; the abrasive is calcium carbonate and/or silicon dioxide.

6. The hemostatic, heat-clearing and dampness-removing toothpaste according to claim 1, wherein the foaming agent is sodium lauryl sulfate; the fluoride is food-grade sodium fluoride or sodium monofluorophosphate.

7. The preparation method of the hemostatic, damp-heat clearing toothpaste according to any one of claims 1 to 6, wherein the method comprises the following steps:

s1: mixing ethanol, hinokitiol, menthol and laurocapram uniformly;

s2: adding water to swell sorbitol and CMC;

s3: and adding water, the premix obtained in the step S1 and other materials into the swelling solution obtained in the step S2, uniformly stirring, grinding and degassing to obtain the toothpaste for stopping bleeding and clearing damp-heat.