CN108125832B - Bath agent for stopping bleeding, clearing away damp-heat and preparation method thereof - Google Patents

Abstract

The invention relates to a bath agent for stopping bleeding, clearing damp and heat and a preparation method thereof, wherein the bath agent comprises the following components in percentage by mass: 5-20% of sulfate anionic surfactant, 0-20% of sulfosuccinic acid monoester disodium salt, 0-10% of amphoteric imidazoline surfactant, 2-10% of betaine, 0-5% of alkanolamide, 0-2% of fatting agent, 0-3% of humectant, 0.2-1% of penetration enhancer, 1-3% of solubilizer, 0-0.5% of preservative, 0-1% of essence, 1-3% of cypress oil, 1-3% of thickener and the balance of water; the penetration enhancer is a mixture of laurocapram and menthol, and the mass ratio of the laurocapram to the menthol to the hinokitiol is 0.2-0.3: 0.05-0.1: 1-2; the solubilizer is one or more of alkyl glycoside, tween or polyoxyethylene hydrogenated castor oil. The bathing agent provided by the invention has the characteristics of good cleaning performance, softness and no stimulation, and can improve skin sensitivity, blood vessel fragility and easy bleeding when being applied to daily body cleaning, and also has the advantages of clearing away damp heat.

Description

Bath agent for stopping bleeding, clearing away damp-heat and preparation method thereof

Technical Field

The invention relates to the technical field of synthetic detergents, in particular to a bath agent for stopping bleeding, clearing away heat and promoting diuresis and a preparation method thereof.

Background

Due to the fact that people have different daily dietary hobbies and physical qualities and the strong degreasing force of a common bath product surfactant, the skin epidermis is reddish, blood vessels are fragile, blood is easy to damage, and the skin is dry and cracked. With the improvement of cleaning requirements of people, the body cleaning product is endowed with more efficacies, and series products of skin care, essential oil, whitening and the like are continuously emerged, so that the functions of the body cleaning product are enriched. Some branded products improve the bleeding phenomenon by adding traditional Chinese medicine and western medicine components, but are limited by insufficient skin absorption and unsatisfactory hemostatic effect, so that a pure natural, safe and efficient body cleaning product for inhibiting bleeding and stopping bleeding becomes an urgent need for solving the problem in the industry.

Disclosure of Invention

The bath agent has the characteristics of good cleaning performance, softness and no stimulation, and can improve sensitive skin, fragile blood vessels and easy bleeding when being applied to daily body cleaning, and also has the advantages of clearing damp and heat.

The invention also aims to provide a preparation method of the bath agent for stopping bleeding and clearing damp and heat.

In order to achieve the purpose, the invention adopts the following technical scheme:

the bath agent for stopping bleeding, clearing away heat and promoting diuresis consists of the following components in percentage by mass:

5-20% of sulfate anionic surfactant, 0-20% of sulfosuccinic acid monoester disodium salt, 0-10% of amphoteric imidazoline surfactant, 2-10% of betaine, 0-5% of alkanolamide, 0-2% of fatting agent, 0-3% of humectant, 0.2-1% of penetration enhancer, 1-3% of solubilizer, 0-0.5% of preservative, 0-1% of essence, 1-3% of cypress oil, 0-3% of thickener and the balance of water;

the penetration enhancer is a mixture of laurocapram and menthol, and the mass ratio of the laurocapram to the menthol to the hinokitiol is 0.2-0.3: 0.05-0.1: 1-2; the solubilizer is one or more of alkyl glycoside, tween or polyoxyethylene hydrogenated castor oil.

The inventor of the invention finds that the natural cacumen biotae has good effects of stopping bleeding and coagulating blood when trying to prepare a bath agent with the functions of stopping bleeding and clearing damp and heat, but has the problems of low content of active ingredients in a powder state, incapability of using a general transparent system and the like. After a plurality of attempts, the inventor finds that the effective components of hinoki oil (cedar oil), such as quercetin and tannin, have high contents, are transparent, have oil solubility and the like, so that the hinoki oil has good effects of stopping bleeding, coagulating blood and clearing damp-heat, and has strong antibacterial power on pathogenic bacteria such as staphylococcus aureus, bacillus anthracis and the like. How to generate higher percutaneous absorption rate, the effective components in the hinoki oil are more fully absorbed by human body, thereby playing the key role in efficiently stopping bleeding, coagulating blood and clearing damp-heat.

Menthol has stimulating effect on skin, can slowly penetrate into skin to cause long-time congestion, and reflexively causes deep blood vessel change to adjust blood vessel function to achieve the effect of penetration and absorption; it also has antiinflammatory and analgesic effects. Laurocapram is a nonpolar scalp promoter, and has effects of softening cutin, enhancing permeability, making medicine penetrate skin barrier, increasing local or systemic blood concentration, improving bioavailability of preparation, promoting transdermal effect on lipophilic and hydrophilic medicine, and low toxicity.

The inventor found in experiments that the bath agent prepared by using menthol and hinoki oil has partial hemostasis and coagulation effects in use, and the bath agent prepared by using laurocapram and hinoki oil has better hemostasis and coagulation effects in a short-term test, but has increased irritation, and found that the irritation is caused by excessive absorption of a preservative in the bath agent through the permeation promoting effect of the laurocapram. After repeated experiments, the inventor finds that when the mass ratio of the laurocapram to the menthol to the hinokitiol is 0.2-0.3: 0.05-0.1: 1-2 hours, it has minimal irritation and good hemostatic and blood coagulation effects. This may be because: menthol stimulates nerve ending receptors to firstly generate cold feeling, oil-soluble hinoki oil of the menthol slowly penetrates into the skin and reflects to cause deep vascular change and adjust vascular function, thereby achieving the effect of penetration promotion treatment, and the anti-inflammatory and analgesic effects of the menthol reduce the irritation of the bathing agent. And when the laurocapram plays a role in softening the horny layer and increasing the permeability, the laurocapram and the function of activating blood vessels of menthol take effect simultaneously, so that a synergistic permeation promoting effect is generated, the using amount of an irritant source is reduced, and the skin is promoted to absorb the effective components of the hinokitiol more efficiently.

For the structural characteristics of skin mucosa, the surfactant has solubilization and emulsification effects on the effective components of the oil phase, and also needs to have the performances of lower surface tension, better wetting and the like in an aqueous solution. A relevant comparison was therefore made for emulsions of different surfactants (aqueous surfactant solutions for emulsifying solubilised hinoki oil). Aiming at the emulsification and solubilization capacities of hinoki oil, menthol and laurocapram: polyoxyethylene hydrogenated castor oil (RH 40) > tween (tween 80) > alkyl glycoside (C8-14 APG); 0.1% surface tension of aqueous surfactant solution (unit: mN/m): c8-14APG (28.1) < RH40(43) < Twen80 (47.84). The alkyl glycoside (C8-14 APG), tween (Twen80) and polyoxyethylene hydrogenated castor oil (RH 40) have good emulsifying and solubilizing abilities for hinoki oil, menthol and laurocapram, and can be used by uniformly dispersing effective components and crude design of hinoki oil on the surface of skin of human body when bathing the human body. Therefore, one or more of alkyl glycoside, tween or polyoxyethylene hydrogenated castor oil is/are selected as the solubilizer.

Preferably, the hinoki oil is a natural extracted cypress essential oil.

Preferably, the solubilizer is prepared from polyoxyethylene hydrogenated castor oil and alkyl glycoside according to the mass ratio of 1: 1-2. The compound solubilizer provides stronger solubilizing capability and endows insoluble substances such as hinoki oil in the bath agent formula. Better dispersion stability of menthol and laurocapram.

Preferably, the bath agent consists of the following components in percentage by mass:

5-15% of sulfate anionic surfactant, 0-15% of sulfosuccinic acid monoester disodium salt, 0-8% of amphoteric imidazoline surfactant, 2-6% of betaine, 0-3% of alkanolamide, 0-2% of fatting agent, 0-2% of humectant, 0.2-0.5% of penetration enhancer, 1-3% of solubilizer, 0-0.3% of preservative, 0-1% of essence, 1-2% of hinoki oil, 0-2% of thickener and the balance of water.

Preferably, the sulfate anionic surfactant is fatty alcohol-polyoxyethylene ether sulfate; the sulfosuccinic acid monoester disodium salt is an alcohol ether sulfosuccinic acid monoester disodium salt synthesized by taking fatty alcohol-polyoxyethylene ether and maleic anhydride as main raw materials; the amphoteric imidazoline surfactant is synthesized by fatty acid and hydroxyethyl ethylenediamine through dehydration condensation reaction; the betaine is one or more of alkyl betaine, alkyl amide betaine or hydroxypropyl betaine; the alkanolamide is a nonionic alkanolamide surfactant generated by heating and condensing fatty acid and alkanolamine.

Preferably, the fat-endowing agent is one or more of diglycerol, triglycerol, polyquaternium-51, methyl glucitol polyether-10, methyl glucitol polyether-20, poly (glyceryl methacrylate)/propylene glycol/PVM/MA copolymer, poly (glyceryl methacrylate)/propylene glycol, 1, 2-hexanediol, trimethyl glycine or PEG-7 olive oleate.

Preferably, the humectant is one or more of polyols, natural moisturizing factors or amino acids; the preservative is one or more of kaempferol, benzoic acid and salts thereof), sorbic acid and salts thereof; the thickening agent is sodium chloride and/or ammonium chloride; the essence is bath essence.

The preparation method of the bath agent for stopping bleeding and clearing damp-heat comprises the following steps:

s1: uniformly mixing the hinoki oil, the penetration enhancer and the solubilizer to obtain a premix;

s2: sequentially adding a sulfate anionic surfactant, a sulfosuccinic acid monoester disodium salt, an amphoteric imidazoline surfactant, betaine and alkanolamide into water under the stirring condition, stirring and dissolving uniformly, adding a fatting agent, a humectant, a premix obtained in S1, a preservative and essence, stirring uniformly, adding a thickening agent, stirring uniformly, standing and aging to obtain the bath agent for stopping bleeding, clearing heat and removing dampness.

Compared with the prior art, the invention has the following beneficial effects:

the bath agent provided by the invention adopts hinoki oil as a main effective component, has the effects of stopping bleeding, coagulating blood, clearing damp and heat and the like, is oil-soluble, has high effective component content, and is suitable for various cleaning systems; the invention selects the laurocapram and menthol to be compounded as the penetration enhancer, and has the advantages of increasing the penetration and absorption capacity of skin cells, reducing the irritation and the like; in addition, one or more of alkyl glycoside, tween or polyoxyethylene hydrogenated castor oil is used as a solubilizer, and the solubilizers can efficiently solubilize the oil-soluble effective components such as hinoki oil and the like and also provide good stability of a formula system. The bath agent provided by the invention has the characteristics of hemostasis, strong blood coagulation, strong bacteriostatic ability, naturalness and no toxicity, and is suitable for being widely used in civil and public places.

Detailed Description

The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.

Unless otherwise indicated, reagents and materials used in the present invention are commercially available.

The main raw material information is as follows:

AES, CAB, sulfosuccinic acid monoester disodium salt, 6501, amphoteric imidazoline, amino acid humectant, polyquaternium humectant, essence, preservative and sodium chloride; is sold on the market;

laurocapram; purchased from open seal Tiandi high-tech chemical technology, Inc., with a content of 99%;

menthol; purchased from Baicao oil refinery for Shuiyan in Jishui county of Jiangxi, with a content of 99.8%;

alkyl glycoside C8-14; purchased from Shanghai Kai chemical Co., Ltd, with a content of 50%;

polyoxyethylene ether hydrogenated castor oil; purchased from basf, germany.

Examples 1 to 6 and comparative examples 1 to 4 are hemostatic, dampness-heat-clearing bathing agents

Examples 1-6 and comparative examples 1-4 provide body wash formulations as set forth in Table 1 below.

Table 1 examples 1-6 and comparative examples 1-4 provide body wash formulations (wt%)

Test method

The related performances of the bath agents prepared in the examples of the invention and the comparative examples are detected by the following methods:

1. the hemostatic and blood coagulation effects are achieved, and bleeding occurs after the hemostatic and blood coagulation effects are achieved for a week by people with sensitive body skin and people who are prone to skin bleeding.

The skin is qualified when no bleeding occurs any more, and the bleeding phenomenon is unqualified

2. And (3) storing the product for 24 hours at the temperature of minus 5 +/-2 ℃ according to a stability detection method in GB 8772 + 2008, and taking out the product to recover the room temperature. The mixture is placed in an oven (40 +/-2 ℃) for 24 hours and taken out to be recovered to the room temperature. And if the state is consistent with the state before the experiment, the test is qualified, otherwise, the test is unqualified.

3. The irritation, optionally 10 persons, was tested by taking a bath with the corresponding bath preparation product for one week, and the state of irritation, itching and discomfort was found to be unacceptable in 2 persons or more, and conversely acceptable.

TABLE 2 Performance test data of the body wash products prepared in examples 1 to 6 and comparative examples 1 to 4

。

As can be seen from the experimental data in the table 2, the solubilizing active substances in the comparative examples 1-3 have good performance and qualified product stability due to the existence of the solubilizing agent. In comparative example 1, laurocapram (main transdermal penetration enhancer) is not added, and the prepared bathing agent has unqualified hemostatic and blood coagulation functions; in comparative example 2, menthol is not added, and the prepared bathing agent has a problem of large irritation although the hemostatic and blood coagulation efficacy is qualified (the effect of laurocapram), and is analyzed to lack the analgesic, analgesic and anti-inflammatory effects of menthol; in the comparative example 3, the addition amount of hinoki oil is less, and the prepared bathing agent has poor effects of clearing damp heat and stopping bleeding; comparative example 4 does not contain any penetration enhancer, and the prepared bath agent cannot effectively solubilize oil-soluble components such as hinoki oil and laurocapram, so that the effective components cannot be uniformly and stably dispersed in the bath agent, and the effects of stopping bleeding and clearing damp and heat are eliminated.

The test results of the above embodiments show that the bathing agent prepared by the invention has the compound penetration enhancer, effectively increases the efficient absorption of the effective components of hinoki oil by skin cells, and enhances the effects of hemostasis, blood coagulation and dampness-heat clearing of the bathing agent. The compound solubilizer is adopted, so that the stable existence of the oil-soluble penetration enhancer and the hinoki essential oil in the bathing agent is better improved, the effective components (oil-soluble) penetration enhancer and the hinoki oil are uniformly dispersed, adsorbed and absorbed through skin at the skin part of a human body when the bathing agent is diluted for use, and the effects of hemostasis, blood coagulation and clearing damp and heat of the product are enhanced.

The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (8)

1. The bath agent for stopping bleeding and clearing damp and heat is characterized by comprising the following components in parts by mass:

5-20% of sulfate anionic surfactant, 0-20% of sulfosuccinic acid monoester disodium salt, 0-10% of amphoteric imidazoline surfactant, 2-10% of betaine, 0-5% of alkanolamide, 0-2% of fatting agent, 0-3% of humectant, 0.2-1% of penetration enhancer, 1-3% of solubilizer, 0-0.5% of preservative, 0-1% of essence, 1-3% of cypress oil, 0-3% of thickener and the balance of water;

the penetration enhancer is a mixture of laurocapram and menthol, and the mass ratio of the laurocapram to the menthol to the hinokitiol is 0.2-0.3: 0.05-0.1: 1-2; the solubilizer is one or more of alkyl glycoside, tween or polyoxyethylene hydrogenated castor oil; the betaine is one or more of alkyl betaine, alkyl amide betaine or hydroxypropyl betaine.

2. The bathing agent for stopping bleeding, clearing away heat and dampness as claimed in claim 1, wherein said hinoki oil is a naturally extracted cypress essential oil.

3. The bath agent for stopping bleeding and clearing away heat and dampness as claimed in claim 1, wherein the solubilizer is prepared from polyoxyethylene hydrogenated castor oil and alkyl glycoside in a mass ratio of 1: 1-2.

4. The bath agent for stopping bleeding and clearing away damp and heat according to claim 1, which is characterized by comprising the following components in percentage by mass:

5-15% of sulfate anionic surfactant, 0-15% of sulfosuccinic acid monoester disodium salt, 0-8% of amphoteric imidazoline surfactant, 2-6% of betaine, 0-3% of alkanolamide, 0-2% of fatting agent, 0-2% of humectant, 0.2-0.5% of penetration enhancer, 1-3% of solubilizer, 0-0.3% of preservative, 0-1% of essence, 1-2% of hinoki oil, 0-2% of thickener and the balance of water.

5. The bath agent for stopping bleeding, clearing away heat and dampness as claimed in claim 1, wherein said sulfate anionic surfactant is fatty alcohol-polyoxyethylene ether sulfate; the sulfosuccinic acid monoester disodium salt is an alcohol ether sulfosuccinic acid monoester disodium salt synthesized by taking fatty alcohol-polyoxyethylene ether and maleic anhydride as main raw materials; the amphoteric imidazoline surfactant is synthesized by fatty acid and hydroxyethyl ethylenediamine through dehydration condensation reaction; the alkanolamide is a nonionic alkanolamide surfactant generated by heating and condensing fatty acid and alkanolamine.

6. The bath agent for stopping bleeding and clearing damp and heat according to claim 1, wherein the fat-imparting agent is one or more of diglycerol, triglycerol, polyquaternium-51, methyl gluceth-10, methyl gluceth-20, poly (glyceryl methacrylate)/propylene glycol/PVM/MA copolymer, poly (glyceryl methacrylate)/propylene glycol, 1, 2-hexanediol, trimethyl glycine or PEG-7 olive oleate.

7. The bath agent for stopping bleeding and clearing away damp and heat according to claim 1, wherein the humectant is one or more of polyols, natural moisturizing factors or amino acids; the preservative is one or more of kaempferol, benzoic acid and salts thereof, sorbic acid and salts thereof; the thickening agent is sodium chloride or ammonium chloride; the essence is bath essence.

8. The method for preparing the bath agent for stopping bleeding, clearing away heat and dampness as claimed in any one of claims 1 to 7, wherein the method comprises the following steps:

s1: uniformly mixing the hinoki oil, the penetration enhancer and the solubilizer to obtain a premix;

s2: sequentially adding a sulfate anionic surfactant, a sulfosuccinic acid monoester disodium salt, an amphoteric imidazoline surfactant, betaine and alkanolamide into water under the stirring condition, stirring and dissolving uniformly, adding a fatting agent, a humectant, a premix obtained in S1, a preservative and essence, stirring uniformly, adding a thickening agent, stirring uniformly, standing and aging to obtain the bath agent for stopping bleeding, clearing heat and removing dampness.