JP6006478B2 - Skin circulation promoting cosmetics - Google Patents

Description

  The present invention relates to a blood circulation promoting cosmetic that continuously increases blood flow in the skin.

  Promoting blood circulation in the skin is very beneficial for physical health and beauty. Its effects, efficacy and application fields such as promotion of body metabolism, prevention of skin dullness, supply of nutrients and moisture to skin tissue, etc. Is immeasurable. For example, a method is known in which skin blood flow is increased to safely and effectively improve symptoms caused by poor blood circulation such as coldness and stiff shoulders (Patent Document 1). It is also known that the production of hair is promoted by infiltrating the hair root with a blood circulation promoter and dilating blood vessels (Patent Document 2).

  On the other hand, many blood circulation promoters such as capsaicin or capsaicin-containing chili powder, chili extract, etc. have been reported. In addition, it is also known to have an advantage of low skin irritation (Patent Document 3). Moreover, it is possible to promote the blood circulation of the skin also by containing carbon dioxide gas, and geraniol etc. can be added as a fragrance | flavor (patent document 4).

JP 2009-2335016 A JP 2009-139368 A JP 2009-139371 A JP 2009-161439 A

  However, in order to obtain a cosmetic that brings skin blood circulation promoting action, when a fragrance such as geraniol or nerol is added as an active ingredient, it is necessary to make the concentration range that exhibits sufficient skin blood circulation promoting action. In the concentration range, the inherent odor of the fragrance tends to increase. In addition, when carbon dioxide is included as an active ingredient in obtaining cosmetics that promote skin blood circulation, carbon dioxide is quickly released into the atmosphere or metabolized in the living body after application to the skin. Therefore, there is a possibility that the sustainability of the skin circulation promotion time cannot be sufficiently achieved.

  Accordingly, an object of the present invention is to provide a skin circulation promoting cosmetic that sufficiently exhibits the blood circulation promoting action of the skin, maintains the action continuously, has low skin irritation, and does not have an unpleasant odor during use. There is to do.

  Therefore, the present inventors have conducted various studies to develop skin circulation promoting cosmetics capable of continuously expressing good blood circulation promoting action while reducing the concentration of geraniol and nerol in order to reduce unpleasant odors. When a specific amount of carbon dioxide gas is used in combination with a low concentration of geraniol or nerol, the geraniol or nerol alone has a low content such that the skin blood circulation promoting action is extremely weak or the skin blood circulation promoting action is not recognized. It is possible to obtain a skin circulation promoting cosmetic that exhibits a good skin circulation promoting effect and that can exhibit an excellent skin circulation promoting effect that cannot be recognized only by containing carbon dioxide alone. I found it.

  That is, the present invention provides a skin blood circulation promoting cosmetic containing 100 to 20000 ppm of carbon dioxide and 0.001 to 0.5% by mass of geraniol or nerol.

  According to the present invention, even when geraniol or nerol is contained at a low content where the odor does not matter, percutaneously absorbed together with carbon dioxide gas, a good skin blood circulation promoting action can be recognized, and further this skin blood circulation promotion. The effect can be sustained effectively over a long period of time. Therefore, it is possible to obtain an extremely high effect of promoting skin circulation, and it is possible to contribute to the health and beauty of the user by continuously increasing the skin blood flow. Therefore, the present invention is very useful as a skin blood circulation promoting cosmetic.

When the skin blood circulation promoting cosmetic of the present invention is applied to the inner side of the forearm and then peeled off, the blood flow change result after 7 minutes of Comparative Example 1 and Examples 1 to 6, ie, the persistence of the skin blood circulation promoting action is shown. It is explanatory drawing. In each system, when CO ₂ (−) does not contain carbon dioxide, CO ₂ (+) shows the result when the carbon dioxide concentration is 1800 ppm. It is explanatory drawing which shows the skin sensation and the blood flow change result of Examples 7-8 and the comparative example 4 at the time of having passed 7 minutes after sticking the skin blood circulation promotion cosmetics of this invention on the inner part of the forearm, and peeling this. is there.

Hereinafter, the present invention will be described in detail.
The skin blood circulation promoting cosmetic of the present invention contains 100 to 20000 ppm of carbon dioxide in the total amount of the skin blood circulation promoting cosmetic. By containing such an amount of carbon dioxide, the skin blood circulation promoting action by geraniol or nerol can be sufficiently expressed even if the content of geraniol or nerol is low. In addition, when carbon dioxide gas is contained alone, it is diffused into the atmosphere or metabolized in the living body with the passage of time, and it is difficult to bring about a sufficient skin blood circulation promoting function over time. In the skin blood circulation promoting cosmetics, in combination with geraniol and nerol, the skin blood circulation promoting action can be exerted greatly over a long period of time. Therefore, the present invention further provides a skin circulation promoting cosmetic containing carbon dioxide of 100 to 20000 ppm and containing 0.001 to 0.5% by mass of geraniol or nerol.

  Carbon dioxide gas is preferably included in the total amount of skin circulation promoting cosmetics from the viewpoint of enhancing the skin blood circulation promoting action of geraniol or nerol with a low content and sufficiently exerting the skin blood circulation promoting action of carbon dioxide gas itself. It contains 150-18000 ppm, More preferably, it contains 400-10000 ppm, More preferably, it contains 1500-2000 ppm.

  For example, when the skin blood circulation promoting cosmetic of the present invention is formed into a sheet, carbon dioxide is mixed with components other than carbon dioxide previously mixed and dissolved into a sheet and carbon dioxide. Is sealed in a carbon dioxide-impermeable container such as an aluminum pillow, so that carbon dioxide gas can be dissolved in the sheet-like skin circulation promoting cosmetic.

  When the skin blood circulation promoting cosmetic of the present invention is filled in an aerosol container or the like at high pressure, a pressure-resistant container is filled with a mixture obtained by mixing and dissolving components other than carbon dioxide in advance and carbon dioxide. The concentration of carbon dioxide can be adjusted by the amount of carbon dioxide to be filled and the partial pressure with the injection gas used together. In the normal pressure system, components other than carbon dioxide gas are mixed and dissolved in advance, and then carbon dioxide gas is saturatedly dissolved or pressurized and dissolved in hermetically mixed, and then filled into the container, or carbon dioxide gas is filled after the mixed solution is filled into the container. It is possible to dissolve the saturated concentration of carbon dioxide gas by filling and replacing with, and sealing and storing.

  The skin blood circulation promoting cosmetic of the present invention is a mode in which carbon dioxide gas is dissolved in the skin blood circulation promoting cosmetic immediately before use, or enclosed in an enclosed container such as an aluminum pillow or an aerosol container, and carbon dioxide gas is promoted in advance. You may employ | adopt the aspect of what is called a use specification etc. which are made to melt | dissolve in cosmetics.

  The skin blood circulation promoting cosmetic of the present invention contains 0.001 to 0.5% by mass of geraniol or nerol in the total amount of the skin blood circulation promoting cosmetic. In general, in order to sufficiently exhibit these skin blood circulation promoting effects by transdermally absorbing geraniol and nerol, it is necessary to contain them in an amount far exceeding 0.5% by mass. However, the skin circulation promoting cosmetic composition of the present invention, in combination with carbon dioxide, can provide an excellent skin circulation promoting action even with a low content of geraniol or nerol, thus weakening the strong rose-like aroma derived from geraniol or nerol. It is possible. In addition, it is difficult to bring about a continuous skin blood circulation promoting effect only by containing carbon dioxide alone. By containing geraniol or nerol, a long-term excellent skin blood circulation promoting effect is exhibited. Can be made.

  For example, when the skin blood circulation promoting cosmetic of the present invention is formed into a sheet shape and applied to the skin, carbon dioxide gas is released into the atmosphere or metabolized in the living body when the sheet is peeled off after 7 minutes have elapsed since application. It is in a state that almost does not exist. That is, when carbon dioxide is contained alone, skin blood circulation promoting action by carbon dioxide is hardly recognized at this point. However, the skin circulation promoting cosmetic composition of the present invention is synergistically enhanced by the combined use of carbon dioxide gas and a low content of geraniol or nerol. It has been confirmed that a high skin blood circulation promoting action continues to be exhibited until a minute has elapsed, and an extremely long-lasting skin blood circulation promoting action can be brought about.

  The content of geraniol or nerol is intended to improve and maintain the blood circulation promoting effect of geraniol or nerol, and from the point of securing the stability of the cosmetic while retaining a weakened odor suitable as a cosmetic, The total amount of the skin circulation promoting cosmetic is preferably 0.005 to 0.4% by mass, more preferably 0.02 to 0.3% by mass, and still more preferably 0.06 to 0.2% by mass. It is. Either geraniol or nerol may be used alone, or both may be used together. In addition, in containing geraniol or nerol, the plant, essential oil, etc. containing these can also be used.

  The normal skin pH of mammals, particularly humans, is usually in the range of 4-6, and changes in the skin pH interfere with skin function. Therefore, the pH of the skin blood circulation promoting cosmetic of the present invention is preferably 7.5 or less, more preferably 3.5 to 6.5, and still more preferably 4.0 in that it exhibits a good skin blood circulation promoting action. ~ 6.0. Such pH may be adjusted by appropriately using a pH adjuster so that the final pH is within the above range. As the pH adjuster, for example, organic acids such as succinic acid, citric acid and tartaric acid or salts thereof, or phosphoric acid or salts thereof are preferably used.

  In addition to the above active ingredients, the skin circulation promoting cosmetic of the present invention is usually used in other cosmetics and pharmaceuticals, for example, powder ingredients, liquid fats, solid fats, waxes, hydrocarbon oils, higher fatty acids, Higher alcohol, synthetic ester oil, silicone, anionic surfactant, cationic surfactant, amphoteric surfactant, nonionic surfactant, heat retention agent, water-soluble polymer compound, thickener, film agent, UV absorber, Sequestering agents, lower alcohols, polyhydric alcohols, sugars, amino acid derivatives, organic amines, synthetic resin emulsions, skin nutrients, vitamins, antioxidants, antioxidant aids, fragrances of ingredients other than geraniol and nerol, Water or the like can be appropriately blended as necessary.

  The fragrance containing ingredients other than geraniol and nerol is not particularly limited, but various documents such as “Synthetic fragrance chemistry and product knowledge”, Motoichi Into, 1996, Chemical Daily, Inc .; “Perfume and Frever Chemicals” (Perfume and Flavor Chemicals) ", Stefan Arctander, 1969, etc., can be suitably used.

The skin circulation promoting cosmetic of the present invention is optimally applied to the skin and used as a cosmetic, pharmaceutical, or quasi-drug applied to the outer skin (including the scalp). For example, it can be used as facial cosmetics such as sheet-like cosmetics, creams, lotions, milky lotions, packs, cosmetics, skin care cosmetics, body cosmetics, scalp hair cosmetics, cleaning agents, gels, ointments and the like. Each may take any form such as a sheet, liquid, emulsion, paste, gel, powder, granule, pellet or the like.
Moreover, what is necessary is just to select and mix | blend other components suitably other than the said active ingredient according to these desired uses.

  EXAMPLES Hereinafter, although this invention is demonstrated concretely based on an Example, this invention is not limited to these Examples.

[Examples 1-6, Comparative Examples 1-3]
After preparing an uncrosslinked hydrated gel stock solution according to the formulation shown in Table 1, gel sheets containing each component were prepared.

Specifically, first, a mixed solution of glycerin and propylene glycol is put into a kneader, and added in the order of carboxymethylcellulose dispersed in an aqueous succinic acid solution, dry aluminum hydroxide gel, methyl parahydroxybenzoate, and water-soluble. A gel was prepared. Next, geraniol or nerol is mixed with the obtained gel at an appropriate concentration, and this uncrosslinked gel is sandwiched between EVOH (ethylene / vinyl alcohol copolymer) films in which a PET (polyethylene) film and a nonwoven fabric are laminated, The hydrated gel was spread so as to have a thickness of 1.5 mm by a Baker type applicator. Further, aging was carried out at 50 ° C. for 5 days to complete the crosslinking reaction of the hydrogel layer to obtain a gel sheet. Next, the obtained gel sheet was cut into a square shape (area: 25 cm ² ), sealed with carbon dioxide in an aluminum pillow, and a sheet in which carbon dioxide was dissolved in the gel was prepared and stored at room temperature for 5 days. An evaluation gel sheet was obtained. The pH of the evaluation gel sheet was 4.0 to 6.0.

In addition, although 0.878 mL of carbon dioxide gas at 1 atmosphere is dissolved with respect to 1 g of water, when this carbon dioxide gas is converted into mass, it becomes about 0.0018 g (20 ° C., 1 atm). Therefore, when it is assumed that the evaluation gel sheet (water activity value (actual measurement): 0.985) used for evaluation in the present invention is composed entirely of water, the amount of carbon dioxide contained in the gel sheet is obtained by converting carbon dioxide to aluminum. When sealed in a pillow at normal pressure, it is estimated to be about 1800 ppm.
Each evaluation was performed according to the method shown below using the obtained evaluation gel sheet.

<Odor evaluation>
The aluminum pillow in which each evaluation gel sheet obtained in Examples 1 to 6 and Comparative Examples 1 to 3 is enclosed is opened, and the evaluation gel sheet is quickly applied to the inner side of the forearm, and the subject is asked to investigate the odor at that time. And evaluated according to the following criteria. The obtained results are shown in Table 1.
5: There is almost no smell and I don't mind 4: There is a smell but it's a pleasant smell, I don't care 3: There is a smell, but I'm a little worried, but it's not uncomfortable 2: There is a smell but somewhat uncomfortable 1: The smell Strongly uncomfortable

<Evaluation of skin blood circulation promoting effect>
The aluminum pillow in which each evaluation gel sheet obtained in Examples 1 to 6 and Comparative Examples 1 to 3 was encapsulated was opened, the evaluation gel sheet was applied to the inner side of the forearm for 7 minutes, peeled off, and applied for 7 minutes before and after application. Each blood flow was measured after 7 minutes had passed after peeling. For the blood flow volume, the blood flow in the forearm was measured using a real-time blood flow imaging device FLPI (Moor Instruments Ltd., Moor FLPI). The blood flow after peeling the sheet is defined as the blood flow at the time when 7 minutes have elapsed after peeling, with the skin blood flow in the forearm before the sheet is attached as 100, and the blood circulation promoting effect and skin blood circulation promoting effect are shown. As an indicator of sustainability. The change in blood flow before the sheet sticking and at the time when 7 minutes have passed after sticking and peeling is shown as an average value of the measurement performed three times or more. Moreover, about each evaluation gel sheet obtained in Examples 1-6 and Comparative Examples 1-3, also when it was set as the sheet | seat which does not dissolve carbon dioxide, it evaluated similarly. The obtained results are shown in FIG.

  According to Table 1, although the smell was hardly worried in Examples 1-6, it was judged that the rose-like fragrance was quite strong and uncomfortable in Comparative Example 2. As shown in Comparative Example 3, it was judged that nerol had an odor as well as geraniol and was uncomfortable as a skin cosmetic.

  Moreover, according to FIG. 1, in the sheet | seat of the comparative example 1 which does not contain geraniol and nerol, blood flow volume is lower than before gel sheet sticking regardless of the presence or absence of carbon dioxide gas, and shows a blood flow rate of about 95% before sticking. Only. This is presumably because the moisture contained in the gel sheet transferred to the skin, the skin surface temperature was lowered by the heat of water evaporation, and the blood flow was reduced compared to before the sheet was applied. Further, the skin blood circulation promoting action of carbon dioxide gas disappears after 7 minutes from the peeling of the sheet, and in the sheet of Comparative Example 1 containing no geraniol and nerol, the skin blood circulation promoting action may not be sustained. Recognize. This evaluation uses the change in blood flow of Comparative Example 1 as an index, and the blood flow at the time when 7 minutes have passed since the sheet in Comparative Example 1 was applied to the blood flow before application of the sheet. It was defined that a skin blood circulation promoting action was observed when the blood flow rate exceeded (about 95%).

  When Examples 1 to 3 containing geraniol were affixed as sheets that do not dissolve carbon dioxide, no clear blood circulation promoting action was observed. On the other hand, when a sheet in which the carbon dioxide gas of Examples 1 to 3 is dissolved is pasted, the skin blood circulation promoting action at the time of 7 minutes after the sheet peeling, which was hardly recognized in the sheet in which the carbon dioxide gas was not dissolved, It was clearly confirmed. Therefore, at geraniol concentrations of 0.01, 0.05, and 0.1% by mass, the skin blood circulation promoting action is synergistically enhanced by carbon dioxide and geraniol, and the skin blood circulation promoting sustained action that is not clearly recognized in each case. You can see clearly.

  In Examples 4 to 6 containing nerol, when pasted as a sheet in which carbon dioxide was not dissolved, no clear blood circulation promoting action was observed at 7 minutes after the sheet was peeled off under any condition. On the other hand, when the sheets in which the carbon dioxide gas of Examples 4 to 6 is dissolved are pasted, the skin blood circulation promoting action at the point of 7 minutes after the sheet peeling, which was hardly recognized in the sheet in which the carbon dioxide gas was not dissolved, It was clearly confirmed. Therefore, at nerol concentrations of 0.05, 0.1, and 0.5% by mass, the skin blood circulation promoting action is synergistically enhanced by carbon dioxide and nerol, and the skin blood circulation promoting and sustained action that is not clearly recognized by each alone. You can see clearly.

[Examples 7 to 8, Comparative Example 4]
As shown in Table 2, a gel sheet containing 0.2% by mass of nerol was prepared in the same manner as in Example 1 for synergistic enhancement of skin blood circulation enhanced by carbon dioxide and nerol. An evaluation gel sheet in which the concentration of carbon dioxide gas to be sealed was 90 ppm to 1800 ppm was produced. Carbon dioxide / nitrogen mixed gas was used to adjust the carbon dioxide concentration, and a mixed gas of carbon dioxide: nitrogen gas = 5: 95 (partial pressure ratio) or carbon dioxide: nitrogen gas = 20: 80 was placed in the aluminum pillow. This was done by enclosing and sealing.

  The obtained aluminum pillow in which each evaluation gel sheet was encapsulated was opened, and the evaluation gel sheet was applied to the inner side of the forearm for 7 minutes and then peeled off. The blood flow increasing action after 7 minutes was compared. The results are shown in FIG. The pH of the evaluation gel sheets in these examples and comparative examples was 4.0 to 6.0.

  According to FIG. 2, even if carbon dioxide and nerol coexist, compared with Examples 7 and 8 where the carbon dioxide concentrations are 360 ppm and 1800 ppm, respectively, in Comparative Example 4 where the carbon dioxide concentration is 90 ppm, almost skin No blood circulation promoting effect was observed.

  Examples of various skin blood circulation promoting cosmetics relating to the present invention will be exemplified below. However, each of the examples exhibits excellent skin blood circulation promoting action and long-lasting skin blood circulation promoting action, and at the same time has no skin irritation. The property was good. In addition, the manufacturing method of the body cosmetics in these Examples followed the method generally used as the manufacturing method in each. Moreover, the pH of the body cosmetics in these examples was 4.0 to 6.0.

[Example 9: lotion]
mass%
Ethanol 3.0
1,3-butylene glycol 6.0
Glycerin 5.0
Propylene glycol 5.0
POE (15) lauryl ether 0.5
Nellore 0.1
Preservative appropriate amount
Purified water residue Components other than carbon dioxide were mixed and stirred to be uniform, and after a predetermined amount was placed in an aluminum pillow, carbon dioxide was sealed to obtain skin circulation promoting skin lotion (carbon dioxide concentration of about 1500 ppm).

[Example 10: Latex]
mass%
Stearic acid 2.5
Cetyl alcohol 1.5
Ethanol 0.5
Vaseline 5.0
Geraniol 0.1
Propylene glycol 3.0
Liquid paraffin 10.0
POE (10) monooleate 2.0
PEG 1500 3.0
Triethanolamine 1.0
Sodium bisulfite 0.01
Carboxyvinyl polymer 0.05
Preservative appropriate amount
Perfume
Purified water residue Components other than carbon dioxide were mixed and stirred to be uniform, and after a predetermined amount was placed in an aluminum pillow, carbon dioxide was injected to obtain a skin circulation promoting emulsion (carbon dioxide concentration of about 1300 ppm).

[Example 11: Skin lotion]
mass%
Ethanol 3.0
Lactic acid 0.1
Propylene glycol 2.0
Sodium lactate 0.3
POE (20) hydrogenated castor oil 0.5
Nellore 0.1
Preservative appropriate amount
Perfume
Purified water residue Components other than carbon dioxide were mixed and stirred to be uniform, and after a predetermined amount was placed in an aluminum pillow, carbon dioxide was injected to obtain a skin circulation promoting skin lotion (carbon dioxide concentration of about 1700 ppm).

[Example 12: Aerosol]
mass%
Lauryl phosphate 3.9
Polyglyceryl monolaurate 1.0
Carboxybiminyl polymer 0.1
Acrylic acid / alkyl methacrylate copolymer 0.1
Xanthan gum 0.1
Trimethylglycine 4.9
Propylene glycol 1.6
L-Arginine 3.0
Nicotinic acid dl-α-tocopherol 1.0
Hydroxyethane diphosphonic acid 0.1
Methyl paraoxybenzoate 0.2
Geraniol 0.05
Perfume
Purified water Remaining carbon dioxide and liquefied petroleum gas other than carbon dioxide and liquefied petroleum gas are prepared to prepare a stock solution, and then the mixed liquid is carbon dioxide to be 1.5% of the total amount and liquefied petroleum gas to be 1.2% of the total amount. The gas mixture was sealed in a pressure-resistant container to obtain a massage cosmetic for promoting skin blood circulation (carbon dioxide concentration of about 12000 ppm).

Claims (3)

Carbon dioxide is 100 to 20000 ppm ( however, in the case of a sheet-like skin circulation promoting cosmetic, calculated from the solubility of carbon dioxide gas when the total amount of skin circulation promoting cosmetic is replaced with water under the condition of 1 atm at 20 ° C. is the mean value) containing and, and geraniol to 0.001 mass% or nerol the containing 0.001 to 0.5 wt% skin blood circulation cosmetics:   The skin circulation promoting cosmetic according to claim 1, which is applied to the skin.   The skin circulation promoting cosmetic according to claim 1 or 2, wherein the pH is 7.5 or less.

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