JP2010116376A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic sustaining excellent antimicrobial effects and deodorant effects over a long period of time. <P>SOLUTION: The cosmetic includes (A) ferulic acid, and (B) an antimicrobial. Furthermore, (B) the antimicrobial contains at least one selected from among benzalkonium chloride, isopropylmethylphenol, triclosan, and piroctone olamine. Furthermore, an embodiment etc., containing at least one selected from among chlorhydroxyaluminum, zinc oxide, and zinc phenolsulfonate as (C) an antiperspirant ingredient are preferable. <P>COPYRIGHT: (C)2010,JPO&amp;INPIT

Description

  The present invention relates to a cosmetic, and more particularly to a cosmetic containing ferulic acid and a bactericide.

Body odor-causing bacteria decompose sebum and waste products to generate malodors. On the other hand, a component having a bactericidal effect can suppress the growth of body odor-causing bacteria. For this reason, the cosmetics which exhibit the deodorant effect which suppresses a body odor by mix | blending the component with a bactericidal effect conventionally are utilized widely.
For example, Patent Document 1 discloses a deodorant composition containing a kudin flavonoid having a bactericidal effect.
However, the conventional cosmetics described in Patent Document 1 have insufficient durability for antibacterial effects and deodorant effects.

On the other hand, ferulic acid is known to have an antioxidant action, an ultraviolet absorption effect, a whitening effect, a cell differentiation promoting action, and the like, and is blended in a skin external preparation, a hair restorer, and the like (for example, Patent Documents 2 to 5). reference.).
However, there are few reports focusing on the deodorant effect of ferulic acid.
Patent Document 6 exemplifies ferulic acid as one of the antibacterial active ingredients, but it is an invention relating to a liquid cleaning composition, and the deodorant effect when incorporated into cosmetics is disclosed and suggested. Absent. Further, there is no disclosure of examples in which ferulic acid is actually blended as an antibacterial active ingredient, and the effect is unknown.

JP 2004-300132 A JP-A-2-229102 JP-A 64-13016 JP-A-6-256137 JP-A-5-310526 JP-T-2001-518943

  An object of the present invention is to solve the conventional problems and achieve the following objects. That is, an object of the present invention is to provide a cosmetic that has an excellent antibacterial effect and deodorant effect for a long period of time.

  As a result of intensive studies to achieve the above object, the present inventors have found that an excellent antibacterial effect and deodorant effect can be continuously obtained by using ferulic acid or the like together with a predetermined fungicide. The present invention has been completed.

The present invention is based on the above findings by the present inventors, and means for solving the above problems are as follows. That is,
<1> (A) ferulic acid and (B) a fungicide, wherein the (B) fungicide is at least 1 selected from benzalkonium chloride, isopropylmethylphenol, triclosan, and piroctone olamine A cosmetic comprising seeds.
<2> (C) The cosmetic according to <1>, wherein the antiperspirant component includes at least one selected from chlorohydroxyaluminum, zinc oxide, and zinc phenolsulfonate.

  According to the present invention, the above-mentioned problems in the prior art can be solved and the object can be achieved. By using ferulic acid and the like together with a predetermined bactericidal agent, an excellent antibacterial effect and deodorant effect can be obtained for a long time. A cosmetic that lasts for a long time can be provided.

(Cosmetics)
The cosmetic of the present invention contains at least (A) ferulic acid and (B) a bactericide described later, and further contains (C) an antiperspirant component and other components as necessary. .
In addition, the said cosmetics can also be used as a deodorant agent.

<(A) Ferulic acid>
The (A) ferulic acid imparts an antibacterial effect to cosmetics, and when used in combination with a specific (B) bactericide to be described later, the antibacterial effect and its durability are improved, and the antibacterial has excellent long-term cosmetics Demonstrate effect and deodorant effect.

(A) There is no restriction | limiting in particular as a compounding quantity of ferulic acid, Although it can select suitably according to the objective, 0.01 to 10.0 mass% is preferable, 0.1 to 5 mass% 0.0 mass% or less is more preferable, and 0.5 mass% or more and 3.0 mass% or less is especially preferable.
(A) If the blending amount of ferulic acid is less than 0.01% by mass, sufficient antibacterial properties and the effect of improving its sustainability may not be obtained. If it exceeds 10% by mass, skin irritation is increased. It may not be preferable as a cosmetic.

Further, the blending amount of (A) ferulic acid is preferably 2 to 50 times, more preferably 5 to 10 times the blending amount of (B) bactericide described below.
When the blending amount of (A) ferulic acid is less than twice the blending amount of (B) bactericidal agent, antibacterial properties and its sustainability may decrease, and when exceeding 50 times, skin irritation increases. There is.

<(B) Disinfectant>
The (B) fungicide sterilizes body odor-causing bacteria, suppresses its growth, and imparts a deodorant effect to the cosmetic. Moreover, by using together with (A) ferulic acid, an antibacterial effect and its sustainability are improved, and cosmetics exhibit an excellent antibacterial effect and deodorant effect over a long period of time.

  The (B) bactericidal agent preferably contains at least one selected from benzalkonium chloride, isopropylmethylphenol, triclosan, and piroctone olamine from the viewpoint of antibacterial properties and durability.

(B) There is no restriction | limiting in particular as a compounding quantity of a disinfectant, Although it can select suitably according to the objective, 0.001 mass% or more and 10.0 mass% or less are preferable, and 0.05 mass% or more 5 0.0 mass% or less is more preferable.
(B) When the blending amount of the bactericidal agent is less than 0.001% by mass, sufficient antibacterial properties and the effect of improving the sustainability may not be obtained. When the blending amount exceeds 10% by mass, the skin irritation increases. It may not be preferable as a cosmetic.

<(C) Antiperspirant ingredient>
In the present invention, it was found that the antibacterial property, its durability, and the deodorant effect can be further improved by blending (C) an antiperspirant component in addition to (A) ferulic acid and (B) a bactericidal agent.

As said (C) antiperspirant component, it may be used individually by 1 type chosen from chlorohydroxy aluminum, zinc oxide, and zinc phenolsulfonate, and may be used together 2 or more types.
By making such a component (C) an antiperspirant component, the secretion of sweat is suppressed by the astringent action, and at the same time, the retention of (A) ferulic acid and (B) bactericidal agent on the skin is improved, thereby providing an antibacterial effect. In addition, the effect of further improving the deodorant effect can be obtained.

(C) There is no restriction | limiting in particular as a compounding quantity of an antiperspirant component, Although it can select suitably according to the objective, 1.0 mass% or more and 30.0 mass% or less are preferable, and 5.0 mass% or more 25.0 mass% or less is more preferable.
(C) When the blending amount of the antiperspirant component is less than 1.0% by mass, various effects of blending may not be improved. When it exceeds 30% by mass, white residue on the skin is generated. It may not be preferable.

<Other ingredients>
As said other component, the arbitrary component normally added to cosmetics can be mix | blended in the range which does not impair the effect of this invention.
Examples of other components include oils and fats, waxes, silicones, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, surfactants, polymer compounds, antioxidants, dyes, emulsion stabilizers, pH Examples include, but are not limited to, regulators, astringents, preservatives, UV absorbers, chelating agents, moisturizers, thickeners, cooling agents, anti-inflammatory agents, amino acids, vitamins, and various plant extracts. Is not to be done.

<PH of cosmetics>
The pH (hydrogen ion index) of the cosmetic of the present invention is preferably 3 or more and 7 or less, more preferably 3 or more and 5 or less, when measured at room temperature (25 ° C.).
If the pH of the cosmetic is 3 or more and 7 or less, an effect of suppressing the growth of body odor-causing bacteria (skin resident bacteria) can be obtained.

<Cosmetic formulation>
The dosage form of the cosmetic of the present invention is not particularly limited, and unless it impairs the effects of the present invention, an aerosol system, gel system, paste system, ointment system, oil liquid system, water-oil two-phase system, water-oil -A wide range of dosage forms such as a three-phase powder system, an emulsification system, and a solubilization system can be taken. That is, it can be widely applied in various dosage forms such as aerosol, stick, powder, lotion, mist, spray, impregnated sheet, patch, shampoo, body soap, facial cleanser, emulsion, cream, gel, pack and the like.

  In the case of an aerosol type, as a propellant, hydrocarbon gas (LPG) such as propane, isobutane, normal butane, isopentane, neopentane, and liquefied gas such as dimethyl ether (DME), in addition to these, carbon dioxide gas, Nitrogen gas or the like can be used. In particular, it is preferable to use a hydrocarbon-based gas. Said propellant can be used individually or in mixture of 2 or more types, respectively. As a compounding quantity, it is preferable that it is the range of 45-98 mass% in aerosol type cosmetics.

  EXAMPLES Next, although an Example and a comparative example are given and this invention is demonstrated more concretely, this invention is not restrict | limited to the following Example. In addition, the unit of the compounding quantity in the following table | surface is the mass%, and the whole quantity is 100%.

(Examples 1-30)
Cosmetics having the composition shown in Table 1 below were prepared.
About the obtained cosmetics, the antibacterial effect and the deodorant effect were evaluated by the following methods. These results are shown in Tables 1 and 2 below.

<Method for evaluating antibacterial effect>
For 10 male and female subjects, 0.1 g of cosmetics was applied to one axilla and no treatment was applied to the other axilla, then 1 hour, 4 hours, 7 hours, The viable count of the axilla part after 10 hours was measured according to the following procedure. The average number of viable bacteria of 10 subjects was determined and evaluated based on the following evaluation criteria.
<< Method for measuring the number of viable bacteria >>
(1) Rub the axilla with a sterile cotton swab moistened with a phosphate buffer solution of pH 7.9 (2.5 cm in diameter), and collect skin resident bacteria.
(2) Soak a cotton swab from which skin resident bacteria are collected in 2 mL of phosphate buffer and stir for 1 minute with a test tube mixer.
(3) The phosphate buffer after stirring is diluted to 10 to 10,000 times, and the diluted solution is applied to an SCDLP medium (trade name: DAIGO, manufactured by Nippon Pharmaceutical Co., Ltd.).
(4) After culturing at 37 ° C. for 2 days, the number of colonies is counted, and the number of viable bacteria in the axilla is calculated.
<< Evaluation criteria >>
A: The logarithmic value obtained by subtracting the number of living bacteria in the application part from the number of living bacteria in the non-application part is 2 log cfu / mL or more. cfu / mL or more and less than 2 log cfu / mL x: The logarithmic value obtained by subtracting the number of viable bacteria in the uncoated area from the number of viable cells in the uncoated area is less than 1 log cfu / mL. Of duration.

<Evaluation method of deodorant effect>
For 20 male and female subjects, 0.1 g of cosmetics was applied to each axilla, no treatment was applied to the other axilla, and then a pre-cleaned gauze was sewn to the axilla Was worn for 10 hours. From the start of wearing, after 1 hour, 4 hours, 7 hours, and 10 hours, the expert panelist sensory-evaluated the odor adhering to the gauze based on the following evaluation criteria.
<< Evaluation criteria >>
First, the odor attached to the gauze of each subject was evaluated according to the following criteria.
3 points: The gauze on the application side is much weaker in odor intensity than the gauze in the non-application area. 2 points: The gauze on the application area side is considerably weaker in odor than the gauze in the non-application area. The gauze has a slightly weaker odor intensity than the gauze in the non-applied part. 0 point: The gauze in the applied part side is equivalent to the gauze in the non-applied part. Next, the average score of 20 subjects is obtained and based on this, the deodorizing effect Was evaluated as follows.
A: The average score of 20 subjects is 2.5 or more. ○: The average score of 20 subjects is 2 or more and less than 2.5. Δ: The average score of 20 subjects is 1 or more and less than 2 points. : The average score of 20 subjects was less than 1 point. The longest time when the results were ◎ and ○ was taken as the duration of the deodorant effect.

<Evaluation method of skin irritation>
20 μL of the cosmetic was dropped onto a filter paper (diameter 7.5 mm) in a fin chamber (Taisho Pharmaceutical Co., Ltd.) and attached to the back (non-rash area) of 10 adult men who felt they were sensitive skin. The patch was removed 48 hours after application, and evaluation was performed according to the following evaluation criteria (Taro Kawamura, Nisshinkai, 80, 301, 1970) shown below when 24 hours passed. The evaluation score was calculated from the average score of 10 people.
<< Evaluation criteria >>
0 No response 1 Mild erythema 2 Erythema 3 Erythema + edema 4 Erythema + edema + papules, serous papules, small blisters 5 Large blisters

(Comparative Examples 1-10)
Cosmetics having the composition shown in Table 2 below were prepared.
About the obtained cosmetics, the antibacterial effect and the deodorant effect were evaluated by the above-mentioned method. These results are shown in Table 3 below.

From Tables 1 to 3, the cosmetics of Examples 1 to 30 in which ferulic acid and a predetermined fungicide were used in combination were blended with Comparative Examples 1 to 5 in which only ferulic acid or a fungicide was blended, and other fungicides. It can be seen that the durations of the antibacterial effect and the deodorant effect are longer than those of Comparative Examples 6 to 9 and Comparative Example 10 containing only the antiperspirant component.
Moreover, in Examples 14-19 and 23-27 which mix | blended the antiperspirant component, compared with Examples 1-13, 20-22, and 28-30 which do not mix | blend an antiperspirant component, an antimicrobial effect and a deodorant effect are improved further. You can see that

  The cosmetic of the present invention can be suitably used as a cosmetic that has an excellent antibacterial effect and deodorant effect for a long period of time.

Claims (2)

(A) ferulic acid,
(B) contains a disinfectant,
The (B) fungicide contains at least one selected from benzalkonium chloride, isopropylmethylphenol, triclosan, and piroctone olamine.   (C) The cosmetic according to claim 1, comprising at least one selected from chlorohydroxyaluminum, zinc oxide, and zinc phenolsulfonate as an antiperspirant component.