WO2016125771A1

WO2016125771A1 - Composition for external use and use thereof

Info

Publication number: WO2016125771A1
Application number: PCT/JP2016/052999
Authority: WO
Inventors: 純子加古; 美代子荻原
Original assignee: 大塚製薬株式会社
Priority date: 2015-02-03
Filing date: 2016-02-02
Publication date: 2016-08-11
Also published as: TW201628595A; JPWO2016125771A1

Abstract

The main purpose of the present invention is to provide a composition for external use and the like with which the effect derived from a cooling agent, perfume and/or cymen-5-ol can be efficiently manifested. The composition for external use comprises diethoxyethyl succinate and at least one selected from the group consisting of cooling agents, perfumes, and cymen-5-ol.

Description

Composition for external use and use thereof

The present invention relates to an external composition containing diethoxyethyl succinate and a cooling agent, a fragrance and / or cymene-5-ol, and the use of these external compositions.

The composition for external use contains various components. For example, in a composition for external use, a refreshing agent is widely used for the purpose of giving a refreshing feeling to an application site such as skin. The refreshing feeling derived from the refreshing agent not only gives local comfort to the application site, but also gives mental comfort such as refreshing feeling. Moreover, the fragrance | flavor is widely used in order to give desired fragrance to goods. Fragrance is one of the ingredients that further enhances product diversity and consumer satisfaction, such as promoting physical and mental activation and relaxation, and increasing user preference. However, it is known that refreshing agents and fragrances may be irritating to the skin and mucous membranes.

Cymen-5-ol is also known as isopropylmethylphenol and is a component that can be used in cosmetics and the like (Non-Patent Document 1). Cymen-5-ol has a bactericidal action and is known to show a high bactericidal effect against bacteria and molds. However, the amount of cymene-5-ol tends to be limited in cosmetics and pharmaceuticals in consideration of effects on the human body such as allergic reactions.

Thus, although various components are blended in the composition for external use for the purpose of obtaining a desired effect, the amount of use is limited from the viewpoint of irritation to the skin and mucous membranes, and depending on consumers, You may have to give up using it. In addition, simply reducing the content of a component in order to suppress irritation to the skin and mucous membranes does not sufficiently provide the original effects, and lowers the feeling of use and commercial value.

“Japanese Cosmetic Ingredient Labeling Name Dictionary, 1st edition, edited by Japan Cosmetic Industry Association, Yakuji Nippo, April 27, 2001, page 258,“ Cymen-5-ol ”column

The present inventors have independently studied a composition containing components such as a cooling agent, a fragrance, and cymene-5-ol, which can be contained in a composition for external use. I noticed that there was a problem that the effect derived from 5-ol could not be fully exhibited, and I focused on this.

Therefore, the main object of the present invention is to provide a composition or the like that can efficiently exhibit the effect derived from the refreshing agent. Moreover, this invention mainly aims to provide the composition etc. which can exhibit the effect derived from a fragrance | flavor efficiently. In addition, the main object of the present invention is to provide a composition or the like that can efficiently exhibit the effects derived from cymene-5-ol.

As a result of intensive studies in view of the above problems, the present inventors have found that the effect derived from the cooling agent can be efficiently exhibited by using the cooling agent in combination with diethoxyethyl succinate. In addition, the present inventors have found that an effect derived from a perfume can be efficiently exhibited by using the perfume and diethoxyethyl succinate in combination. Further, the present inventors have found that the effects derived from cymene-5-ol can be efficiently exhibited by using cymene-5-ol and diethoxyethyl succinate in combination. The present invention has been completed as a result of further studies based on this finding, and is described below.
Item 1. A composition for external use containing diethoxyethyl succinate and at least one selected from the group consisting of a refreshing agent, a fragrance and cymen-5-ol.
Item 2. Item 2. The external composition according to Item 1, wherein the external composition is a liquid composition.
Item 3. Item 3. The composition for external use according to

Item

1 or 2, which contains 0.01 to 10% by weight of diethoxyethyl succinate in the composition for external use.
Item 4. Item 4. The composition for external use according to any one of Items 1 to 3, comprising 0.01 to 7% by weight of a cooling agent in the composition for external use.
Item 5. Item 5. The composition for external use according to any one of Items 1 to 4, which contains 0.01 to 1.5% by weight of a fragrance in the composition for external use.
Item 6. Item 6. The composition for external use according to any one of Items 1 to 5, which contains 0.01 to 0.2% by weight of cymene-5-ol in the composition for external use.
Item 7. Item 7. The composition for external use according to any one of Items 1 to 6, comprising 1 to 500 parts by weight of diethoxyethyl succinate with respect to 1 part by weight of cymene-5-ol in the composition for external use.
Item 8. Item 8. The composition for external use according to any one of Items 1 to 7, further comprising 2 to 70% by weight of a lower alcohol in the composition for external use.
Item 9. Item 9. The external composition according to any one of Items 1 to 8, which is an external composition for sterilization, deodorization, refresh or refreshment.
Item 10. Item 10. The composition for external use according to any one of Items 1 to 9, wherein the refreshing agent is at least one selected from the group consisting of menthol, menthol derivatives, camphor, peppermint oil and peppermint oil.
Item 11. Item 11. An external product comprising a carrier and / or a container and the external composition according to any one of Items 1 to 10, wherein the external composition is supported on the carrier and / or contained in the container.
Item 12. Item 12. The external product according to Item 11, wherein the carrier is a nonwoven fabric.
Item 13. A method for improving the strength and / or sustainability of a cooling agent, comprising using diethoxyethyl succinate and a cooling agent in combination.
Item 14. Item 14. The method according to Item 13, wherein diethoxyethyl succinate and a cooling agent are used in combination and supported on a support and / or contained in a container.
Item 15. A method for improving the strength and / or sustainability of fragrance derived from a fragrance, characterized by using diethoxyethyl succinate and a fragrance.
Item 16. Item 16. The method according to Item 15, wherein diethoxyethyl succinate and a fragrance are used in combination and supported on a support and / or contained in a container.
Item 17. A method for improving the action of cymene-5-ol, comprising using diethoxyethyl succinate and cymene-5-ol in combination.
Item 18. Item 18. The method according to Item 17, wherein diethoxyethyl succinate and cymene-5-ol are used in combination and supported on a support and / or contained in a container.
Item 19. Item 19. The method according to Item 17 or 18, wherein the action is a bactericidal action or a deodorizing action.

According to the present invention, the strength and / or sustainability of the refreshing agent can be improved by using diethoxyethyl succinate and the refreshing agent in combination. Moreover, according to this invention, the aromatic strength derived from a fragrance | flavor and / or sustainability can be improved by using diethoxyethyl succinate and a fragrance | flavor together. In addition, according to the present invention, the effect derived from cymene-5-ol can be efficiently exhibited by using diethoxyethyl succinate in combination with cymen-5-ol. As described above, according to the present invention, the effects of the refreshing agent, the fragrance, and cymene-5-ol can be efficiently exhibited. Therefore, in the composition for external use, the action derived from these components can be more effectively exhibited without increasing the irritation and the like derived from these components.

FIG. 1 shows that the strength and sustainability of the refreshing agent is improved by the combined use of diethoxyethyl succinate and the refreshing agent.

1. External Composition The external composition of the present invention contains diethoxyethyl succinate and at least one selected from the group consisting of a cooling agent, a fragrance, and cymen-5-ol. Hereinafter, the present invention will be described in more detail.

Diethoxyethyl succinate is a conventionally known component. In the composition for external use of the present invention, the content of diethoxyethyl succinate is not limited as long as the effects of the present invention can be obtained, but diethoxyethyl succinate in the composition for external use is preferably 0.01 to 10% by weight, more preferably. Is 0.2 to 8% by weight, more preferably 0.5 to 5% by weight.

The refreshing agent is not limited as long as the effects of the present invention can be obtained, but menthol such as menthol such as 1-menthol, d-menthol and dl-menthol, menthoxypropanediol, menthyl pyrrolidonecarboxylate, menthyl lactate and menthyl acetate Derivatives, camphor such as d-camphor and dl-camphor, mint oil, peppermint oil and the like are preferable, and l-menthol is preferable. These may be used alone or in combination of two or more.

In the composition for external use of the present invention, the content of the refreshing agent is not limited and does not limit the present invention. For example, when menthol is used as the refreshing agent, the content of menthol is in the composition for external use. 0.01 to 7% by weight, more preferably 0.02 to 2% by weight, still more preferably 0.05 to 1% by weight.

In addition, although there is no limitation as long as the effect of the present invention is obtained, for example, when menthol is used as a cooling agent, diethoxyethyl succinate is preferably 0.1 in 1 part by weight of menthol in the composition for external use of the present invention. To 100 parts by weight, more preferably 0.5 to 50 parts by weight, still more preferably 1 to 50 parts by weight, particularly preferably 1 to 30 parts by weight, particularly more preferably 5 to 20 parts by weight, and still more particularly preferably. Examples are 1 to 5 parts by weight.

The content of the refreshing agent other than menthol and the ratio may be appropriately selected by those skilled in the art according to the type, and may be the above-described value, for example.

The perfume is not limited as long as the effect of the present invention is obtained, but includes natural essential oils such as alcohols, aldehydes, ketones, acids, esters, mono- or sesquiterpene hydrocarbons and other essential oils. Examples include natural fragrances and synthetic fragrances. The fragrance may be a single fragrance or a combination of such natural fragrances, or a single synthetic fragrance, or a combination of natural fragrances and synthetic fragrances. Natural fragrance is preferably exemplified as the fragrance. These may be used alone or in combination of two or more.

In the composition for external use of the present invention, the content of the fragrance is not limited and does not limit the present invention, but the fragrance in the composition for external use is 0.01 to 1.5% by weight, more preferably 0. 01 to 1% by weight, more preferably 0.02 to 1% by weight, particularly preferably 0.02 to 0.8% by weight, particularly more preferably 0.05 to 0.8% by weight, still more preferably 0.0. Examples are from 0.5 to 0.5% by weight.

Cymen-5-ol is also a conventionally known component, also known as isopropylmethylphenol. In the composition for external use of the present invention, the content of cymene-5-ol is not limited as long as the effects of the present invention can be obtained, but 0.01 to 0.2% by weight of cymene-5-ol in the composition for external use, More preferred is 0.05 to 0.2% by weight, still more preferred is 0.05 to 0.1% by weight.

Further, although not limited as long as the effects of the present invention can be obtained, in the composition for external use of the present invention, preferably 1 to 500 parts by weight of diethoxyethyl succinate with respect to 1 part by weight of cymene-5-ol, The amount is preferably 3 to 200 parts by weight, more preferably 5 to 50 parts by weight.

The external composition of the present invention may further contain any cosmetically or pharmaceutically acceptable ingredient as necessary. As such optional components, lower alcohol, water, surfactant, colorant, preservative, antioxidant, emulsifier, oil, polyhydric alcohol, thickener, sequestering agent, bactericidal agent, deodorant, pH Conditioner, cell activator, anti-aging agent, moisturizer, blood circulation promoter, UV absorber, UV scattering agent, vitamins, plant extract, collagen, skin astringent, anti-inflammatory agent, whitening agent, antioxidant, touch Examples of various known components such as an improving agent, and particularly known components used in external compositions applied to the skin such as cosmetics, external pharmaceuticals, and external quasi drugs. These may be used individually by 1 type, may be used in combination of 2 or more type, and should just select and use arbitrary things suitably.

A more detailed example of the optional component will be described. Examples of the lower alcohol include lower alcohols having 1 to 5 carbon atoms such as ethanol, isopropyl alcohol, propyl alcohol, butanol, etc., preferably monovalent lower groups having 1 to 5 carbon atoms. Examples include alcohols, more preferably monovalent lower alcohols having 1 to 3 carbon atoms, still more preferably ethanol, isopropyl alcohol, and the like. These may be used alone or in combination of two or more.

When the lower alcohol is contained, the content of the lower alcohol is not limited as long as the effects of the present invention are not hindered. However, in the composition for external use, it is 2 to 70% by weight, more preferably 10 to 50% by weight, still more preferably 15 to 40% by weight is exemplified. Further, when it is desired to reduce the content of the lower alcohol as much as possible in the composition for external use of the present invention, for example, the content of the lower alcohol in the composition for external use is exemplified to be 15% by weight or less. Or a lower value. Moreover, when it is desired to make the composition for external use of the present invention a so-called alcohol-free product, the lower alcohol is substantially not contained.

Moreover, the composition for external use of the present invention may contain water, and examples of the water include distilled water, tap water, ion-exchanged water, pure water, and ultrapure water.

The content of water is not limited as long as the effect of the present invention is not hindered, but is 30 to 95% by weight, more preferably 50 to 90% by weight, and still more preferably 60 to 80% by weight in the composition for external use.

The composition for external use of the present invention may contain a surfactant, and as the surfactant, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene hydrogenated castor oil, polysorbate 80, polyoxyethylene polyoxypropylene Examples include alkyl ethers, polyoxyethylene phytosterols, polyglycerin fatty acid esters, and the like, preferably polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene hydrogenated castor oil, and the like. Although not limiting the present invention, examples of these commercially available products include NIKKOL PEN-4630, PEN-4620, HCO-60, HCO-50, HCO-40, PEN-4612 (all manufactured by Nikko Chemicals). Is done. These may be used alone or in combination of two or more.

When the surfactant is contained, the content of the surfactant is not limited as long as the effect of the present invention is not hindered, but is 0.1 to 5% by weight, more preferably 0.2 to 3% by weight in the composition for external use. More preferred is 0.4 to 2% by weight.

The composition for external use of the present invention may contain a polyhydric alcohol. As the polyhydric alcohol, glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, , 2-hexanediol and the like. These may be used alone or in combination of two or more.

The form of the composition for external use of the present invention is not particularly limited as long as it can be applied externally, and preferred examples include forms applicable to the skin (including the scalp) and hair. Examples of such forms include liquid, emulsion, cream, paste, mousse, and gel at room temperature (25 ° C.).

In addition, the composition for external use of the present invention comprises a bactericidal agent, deodorant, lotion, moisturizing liquid, milk, cosmetic liquid, cream, pack, facial cleanser, cleansing, body cleanser, shampoo, rinse, hair tonic, deodorant, cleanser. Various external compositions belonging to the fields of cosmetics such as wiping agents, acne treatment agents, bactericidal disinfectants and the like, external medicines, or external quasi drugs can be obtained.

The composition for external use of the present invention is not limited as long as the effect of the present invention can be obtained, but is usually pH 3 to 10, preferably from pH 4 to 10, more preferably from the viewpoint of low irritation to the skin and the feeling of use. Examples thereof include pH 4 to 9, more preferably pH 4 to 8, particularly preferably pH 5 to 7.

The composition for external use of the present invention can be produced by a conventional method according to various forms depending on the purpose of use.

The use amount of the skin composition of the present invention may be appropriately set according to the application site such as skin and hair, age, sex, etc., and the use frequency may be appropriately set in the same manner. / Day may be used for the application site such as skin.

The external composition of the present invention is circulated by being carried on a carrier or being contained in a container.

According to the composition for external use of the present invention, when a refreshing agent is contained, the strength and sustainability of the refreshing feeling derived from the refreshing agent can be improved by the combined use of diethoxyethyl succinate and the refreshing agent. In particular, even when the composition for external use of the present invention is carried and contained in a carrier or a container, according to the present invention, the strength and sustainability of the refreshing feeling derived from the refreshing agent can be improved. Therefore, according to the present invention, the action derived from the refreshing agent can be obtained more efficiently. Therefore, according to the present invention, not only when a sufficient amount of the refreshing agent is contained in the composition for external use, but also when the content of the refreshing agent is kept low, The action derived from the agent can be exhibited more efficiently. Although the action derived from the refreshing agent is known and does not limit the present invention, for example, the refreshing agent can exhibit a refreshing feeling, that is, a refreshing action or a refreshing action. For this reason, when the external composition of this invention contains a refreshing agent, as an example, this can also be said to be an external composition for refreshing and / or refreshing.

Similarly, according to the composition for external use of the present invention, when a fragrance is contained, the strength and sustainability of the fragrance derived from the fragrance can be improved. In particular, even when the composition for external use of the present invention is carried and accommodated in a carrier or a container, according to the present invention, the strength and sustainability of the fragrance derived from the fragrance can be improved. Therefore, according to this invention, the fragrance derived from a fragrance | flavor can be obtained more efficiently. From this, not only when a sufficient amount of perfume is contained in the composition for external use, but also when the perfume content is kept low, it is derived from the refreshing agent according to the present invention. The effect can be exhibited more efficiently. Although the action derived from the fragrance is known and does not limit the present invention, for example, the fragrance can provide a deodorizing action (including an odor masking action by the fragrance) and a refreshing action. For this reason, when the external composition of this invention contains a fragrance | flavor, as an example, this can be said to be an external composition for deodorizing and / or refreshing.

Similarly, according to the composition for external use of the present invention, when it contains cymen-5-ol, it is used in combination with a carrier or a container by using diethoxyethyl succinate and cymen-5-ol together. Even in this case, the residual ratio of cymene-5-ol in the composition for external use can be increased, and cymene-5-ol can be effectively applied to the application site such as skin. Therefore, according to the present invention, the action of cymene-5-ol can be obtained more efficiently. In particular, according to the present invention, the action of cymene-5-ol can be obtained more efficiently even when the composition for external use of the present invention is supported and accommodated in a support or a container. Further, according to the present invention, not only when a sufficient amount of cymene-5-ol is contained in the composition for external use but also when the content of cymene-5-ol is limited to be low. The action of cymene-5-ol can be exhibited more efficiently. Thus, the composition for external use of the present invention contains diethoxyethyl succinate and cymen-5-ol, and in this case, cymen-5-ol is particularly useful as a bactericidal agent and / or deodorant. For this reason, when the composition for external use of the present invention contains cymene-5-ol, it can be said that it is a composition for external use for sterilization and / or deodorization containing cymene-5-ol as an active ingredient.

Accordingly, the present invention provides an external composition to which an action derived from these components is imparted, for example, an external composition for refreshing, refreshing, deodorizing and / or sterilizing.

Moreover, the composition for external use of the present invention has good skin feel, no unpleasant stickiness, and good usability. In these, the carrier and the container are described in the same manner as described later.

2. External Product As described above, the external composition is distributed on a carrier or in a container. Accordingly, the present invention further provides an external product comprising a carrier and / or container and the external composition, wherein the external composition is supported on the carrier and / or contained in the container.

Here, the composition for external use is as described above.

The carrier is not limited as long as it can carry the external composition, and examples thereof include nonwoven fabric, woven fabric, knitted fabric, and paper. For example, when the composition for external use is applied to the skin or the like while being supported on the carrier, the carrier is preferably exemplified by a nonwoven fabric, paper, etc. from the viewpoint of usability and usability when contacting the skin, etc. Preferably a nonwoven fabric etc. are illustrated. These may be used individually by 1 type, may be used in combination of 2 or more types, and may have 1 type, or 2 or more types of laminated structures.

Synthetic fibers such as rayon, polypropylene, polyethylene, polyester, nylon, urethane, acrylic, cellulose, cotton, hemp, silk, pulp, natural fibers, mixed fibers thereof, etc. Regardless of the case, those obtained by mixing various fibers singly or in combination of two or more are exemplified. What is necessary is just to manufacture these support bodies by the conventional method according to various forms. For example, a nonwoven fabric may be produced by appropriately using a known method such as a wet method, a dry method, a spa bond method, a chemical bond method, a thermo bond method, a needle punch method, a spun lace method, and the basis weight is 30 to 80 g / m ^2. Is exemplified. These non-woven fabrics may be commercially available products. Further, the thickness, size, and shape of the nonwoven fabric and the like are not limited and may be set as appropriate according to the purpose of use.

The carrying (contact) of the external composition onto the carrier can be carried out by impregnating, coating, etc. the external composition onto the carrier. The impregnation can be performed, for example, by immersing the support in an external composition or spraying the external composition on the support. The application can be performed by a conventionally known method such as roll coating of the external composition on the support. For example, when the composition for external use is in liquid form, impregnation is preferable from the viewpoint of easy support.

The amount of the external composition supported on the carrier is not limited as long as the external composition can be sufficiently provided to the application site during use, and is appropriately set according to the form of the external composition, the type of the carrier, the application site, etc. do it. For example, when the composition for external use is liquid, it is exemplified that the support is immersed in the composition for external use 3 to 5 times the weight of the support.

Further, the container is not limited as long as it can accommodate the external composition. As described above, the composition for external use is a bactericidal agent, deodorant, lotion, moisturizing liquid, milky lotion, cosmetic liquid, cream, pack, face wash, cleansing, body cleansing agent, shampoo, rinse, hair tonic, deodorant, wiping agent, etc. Since it is used as various compositions belonging to the fields of cosmetics, external medicines or quasi-drugs, conventionally known containers such as liquid-impermeable containers that can contain such compositions are exemplified.

Examples of such containers include those obtained by mixing polyethylene terephthalate, polyethylene, polypropylene, aluminum, glass, polyacrylonitrile, eval, polystyrene and the like alone or in combination of two or more. Moreover, the container may have a laminated structure of one or more of these. As long as this is the case, the size, shape, hardness and the like of the container are not limited.

The accommodation (contact) of the external composition into the container is not limited as long as the external composition is accommodated in the internal space of the container, and the external composition is applied to the body, such as the shape of the external composition, the shape of the container, etc. What is necessary is just to implement based on a conventionally well-known method according to quantity. Further, after the external composition is supported on the carrier, the external composition may be accommodated in a container in a state of being supported on the carrier. Although it does not limit the present invention, cymene-5-ol can be used as a bactericidal agent and deodorant. Therefore, from the viewpoint of achieving simpler and more effective sterilization and deodorization of the application site, a preferred example is a composition for external use. The article may be accommodated in a container after being supported on a sheet-like carrier. As a result, it is possible to obtain external products such as wiping sheets, cleansing sheets, face-wash sheets, lotion sheets, emulsion sheets, wet tissues, wipes sheets, facial masks and the like, which are housed in containers and have a bactericidal or deodorizing action. In addition, although the present invention is not limited, when the composition for external use of the present invention contains a cooling agent and / or a fragrance, from the viewpoint of easy use, the composition for external use is in the form of a sheet. You may accommodate in a container, after making it support on a support body. As described above, external products such as wiping sheets, cleansing sheets, face-washing sheets, lotion sheets, emulsion sheets, wet tissues, wipes sheets, facial masks, etc. having refreshing action, refreshing action, deodorizing action, etc. are obtained. Can do.

The amount of the external composition contained in the container is not limited as long as the external composition can be sufficiently provided to the application site at the time of use, and can be appropriately set according to the form of the external composition, the type of container, the application site, etc. Good. The composition for external use accommodated in the container may be appropriately applied to the application site after the container is opened at the time of use.

According to the external product thus obtained, as described above, a refreshing feeling derived from the refreshing agent contained in the external composition can be obtained efficiently. Moreover, according to the external product obtained in this way, as described above, the fragrance derived from the fragrance contained in the external composition can be efficiently obtained. In addition, according to the externally obtained product thus obtained, the action of cymene-5-ol contained in the externally applied composition can be obtained more efficiently as described above.

Therefore, the present invention further provides a method for improving the strength and / or sustainability of a cooling agent, characterized in that diethoxyethyl succinate and a cooling agent are used in combination. Furthermore, the present invention further improves strength and / or sustainability of the cooling agent, characterized in that diethoxyethyl succinate and a cooling agent are used in combination and supported on a carrier and / or contained in a container. Provide a method.

In addition, from this, the present invention further provides a method for improving the strength and / or sustainability of fragrance derived from a fragrance, characterized in that diethoxyethyl succinate and the fragrance are used in combination. In addition, the present invention further includes the use of a combination of diethoxyethyl succinate and a fragrance, which is supported on a carrier and / or contained in a container, and is characterized by the intensity and / or persistence of the fragrance derived from the fragrance. Provide an improvement method.

From this, the present invention further improves the action (preferably bactericidal action and / or deodorizing action) of cymene-5-ol, characterized in that diethoxyethyl succinate and cymene-5-ol are used in combination. Provide a method. The present invention further provides a method for improving the action of cymene-5-ol, characterized in that diethoxyethyl succinate and cymene-5-ol are used in combination and supported on a support and / or contained in a container. provide.

Here, diethoxyethyl succinate, a cooling agent, a fragrance, cymene-5-ol, a carrier, a carrier, a container, accommodation, optional components, contents of each component, and the like are described in the same manner as described above.

Hereinafter, the present invention will be described with reference to examples, but the present invention is not limited to these examples.

Test example 1
According to the following Table 1, compositions for external use (Examples 1 to 4) containing diethoxyethyl succinate and cymene-5-ol (hereinafter referred to as isopropylmethylphenol (IPMP)) were prepared. Specifically, components 1 to 5 in the table were mixed (liquid A), and components 6 to 11 were mixed separately (liquid B). B liquid was added little by little to the obtained A liquid, and then components 12 and 13 were added. Comparative compositions (Comparative Examples 1 to 4) were prepared in the same manner as in Examples 1 to 4 except that diethoxyethyl succinate was not used. The pH of each composition at room temperature (20-23 ° C.) is 6.5. The total is 100% by weight (the same applies hereinafter).

The obtained composition for external use of Example 1 was sufficiently impregnated into a nonwoven fabric (made of rayon / polypropylene / polyethylene, basis weight 40 g / m ² , sheet shape, size 200 mm × 180 mm per sheet, hereinafter, nonwoven fabric R). After that, it was wrapped in a package (laminated film (polyethylene terephthalate / aluminum / linear low density polyethylene, 260 mm × 155 mm). This was designated as Example 1-1. Compositions for external use in Examples 2 to 4 and comparison In the same manner for the comparative compositions of Examples 1 to 4, Examples 2-1 to 4-1 and Comparative Examples 1-1 to 4-1 were obtained, respectively.

Moreover, it replaced with the nonwoven fabric R, and carried out similarly to Example 4 and the comparative example 4 except having used the nonwoven fabric T (The cellulose, the product made from rayon, the basis weight 40g / m < ² >, the sheet form, the size per sheet 200mm x 180mm). Each was wrapped in a package to obtain Example 4-2 and Comparative Example 4-2.

Then, after storage at 40 ° C. for 6 days, the IPMP residual ratio in the composition was measured and calculated as follows. Specifically, about 2 g of the squeezed solution of each nonwoven fabric was accurately weighed, and a water / methanol mixture (volume ratio at room temperature 3: 2, the same applies hereinafter) was added to make about 40 mL. 2 mL of the internal standard solution was accurately added to this solution, and a water / methanol mixture (3: 2) was added to make 50 mL. After shaking well, the solution was filtered through a membrane filter having a pore size of 0.45 μm or less. The first filtrate was removed, and the next filtrate was used as a sample solution. Separately, about 100 mg of isopropylmethylphenol standard product was accurately weighed and dissolved by adding 40 mL of methanol, and water was added and shaken well to make exactly 100 mL. Further, 2 mL of this solution was accurately taken, 2 mL of the internal standard solution was added accurately, and further a water / methanol mixture (3: 2) was added to make exactly 50 mL to obtain a standard solution. The sample solution and 30 μL of the standard solution were tested by liquid chromatography under the following conditions to determine the ratios QT and QS of the peak area of isopropylmethylphenol to the peak area of the internal standard substance.

Amount of isopropylmethylphenol (C ₁₀ H ₁₄ O: 150.22) (mg)
= Amount of standard isopropylmethylphenol (mg) x (QT / QS) x (1/50)
Internal standard solution: Dilute ethanol solution of propyl paraoxybenzoate (1 → 10000)
Test condition detector: ultraviolet absorption photometer (measurement wavelength: 267 nm)
Column: A stainless steel tube having an inner diameter of 4.6 mm and a length of 15 cm is filled with octadecyl silylated silica gel having a particle diameter of 5 μm.

Column temperature: constant temperature around 40 ° C. Mobile phase: diluted acetic acid (100) (1 → 50) / acetonitrile mixture (2: 1)
Flow rate: Adjusted so that the retention time of isopropylmethylphenol is about 27 minutes.

The IPMP content (% by weight) in the squeezed liquid was calculated from the value thus obtained, and the IPMP content in the composition before impregnation into the nonwoven fabric was calculated in the same manner as described above ( The residual ratio of IPMP was determined by dividing by (% by weight).
IPMP residual ratio (%) = IPMP content (% by weight) in the squeezed liquid × 100 / IPMP content (% by weight) in the composition before impregnation
The results are shown in Table 2.

As is apparent from Table 2, it was found that the residual ratio of IPMP was higher in the external composition of Example 1-1 than in the composition of Comparative Example 1-1. The same tendency was observed in other examples and comparative examples. The same tendency was observed in the compositions of Example 4-2 and Comparative Example 4-2 in which the type of nonwoven fabric was changed.

Thus, when IPMP and diethoxyethyl succinate were used in combination, the IPMP residual rate in the squeezed liquid could be increased as compared with the case where diethoxyethyl succinate was not used. Further, although not shown in the results, the IPMP residual ratio with time in the squeezed liquid could be increased by using diethoxyethyl succinate in combination.

From this, it was found that IPMP can be efficiently left in the squeeze solution by using diethoxyethyl succinate in combination.

Although not shown in the results, the same tendency was observed when a non-woven fabric made of cotton was used.

When the amount of IPMP used is restricted in consideration of allergic reactions and the like, it is particularly important to exhibit the effect efficiently even with a small content. According to the present invention, since the IPMP ratio in the squeezed liquid can be increased in this way, when the composition for external use of the present invention is applied to the skin or the like, the effect of IPMP is more efficiently exhibited at the application site. Can be made. In addition, the external composition can contain IPMP for the purpose of obtaining a bactericidal effect and a deodorizing effect, and according to the present invention, an external composition having an excellent bactericidal and deodorizing effect is obtained. be able to.

Test example 2
According to the following Table 3, a composition for external use (Example 5) containing diethoxyethyl succinate and cymen-5-ol was prepared. Specifically, components 1 to 5 in the table were mixed (liquid A), and components 6 to 11 were mixed separately (liquid B). B liquid was added little by little to the obtained A liquid and mixed. Further, in Example 5, a comparative composition (Comparative Example 5) was prepared in the same manner except that diethoxyethyl succinate was not used.

The nonwoven fabric R was impregnated with 3.2 g of the composition of Example 5 and Comparative Example 5 and quickly contained in the package. One day after the storage, the nonwoven fabric was taken out from the package, and for 4 subjects, Example 5 was wiped on one forearm and Comparative Example 5 was used on the other forearm in the same manner. And the stickiness at the time of drying was evaluated in the following five steps. The larger the value is, the better the skin is and the better it is not sticky.
<Goodness per skin>
5: Compared with the comparative example, the example clearly has better skin contact. 4: Compared with the comparative example, the example has slightly better skin contact. 3: Compared with the comparative example, the example is equivalent. 2: Compared with the comparative example. Examples are somewhat uncomfortable to skin 1: Examples are clearly uncomfortable to skin compared to comparative examples <stickiness when dry>
5: The example is not clearly sticky compared to the comparative example 4: The example is slightly sticky compared to the comparative example 3: The example is equivalent compared to the comparative example 2: The example is compared to the comparative example Slightly sticky 1: Table 4 shows clearly sticky results in Examples compared to Comparative Examples.

Conventionally, compositions used for wiping the body tend to be preferred to have good skin feel and less stickiness when dry. The composition of Comparative Example 5 has good skin perception and reduced stickiness when dry, but as is apparent from Table 4, it is also better in Example 5 than in Comparative Example 5. It was confirmed that the water resistance was not impaired and the stickiness upon drying was reduced. In particular, with respect to the skin, in Example 5, there was a tendency that the sensation of smooth sliding on the skin without resistance was improved. From this, it was found that even when diethoxyethyl succinate and IPMP were used in combination, the composition was satisfactory in terms of skin feel and stickiness.

Test example 3
The forearm was wiped off in the same manner as in Test Example 2, and the fragrance retention at the wiping site when 1, 3, 5, 7, 10, 13, 15, 20 minutes passed after wiping was evaluated in the following five levels. The average value was obtained. It shows that the direction of an Example has the strong fragrance derived from the fragrance | flavor on skin, so that a value is large. In addition, as apparent from Table 3, the composition for external use used in this test example contains a fragrance.
<About perfume retention (on the skin)>
5: The example is clearly stronger than the comparative example 4: The example is slightly stronger than the comparative example 3: The example is equivalent to the comparative example 2: The example is slightly weaker than the comparative example 1: The example is clearly weaker than the comparative example. Further, after removing the nonwoven fabric from the packaging material produced in the same manner as in Test Example 2, the nonwoven fabric when 1, 5, 10, 15, 20, and 30 minutes have passed. The strength of the fragrances scented from the above was evaluated in the following five stages, and the average value was determined. It shows that the direction of an Example has the strong fragrance derived from the fragrance | flavor in a nonwoven fabric, so that a value is large.
<About perfume retention (nonwoven fabric)>
5: The example is clearly stronger than the comparative example 4: The example is slightly stronger than the comparative example 3: The example is equivalent to the comparative example 2: The example is slightly weaker than the comparative example 1: Examples are clearly weaker than Comparative Examples Table 5 shows the results on the skin, and Table 6 shows the results for the nonwoven fabric.

As is clear from Table 5, a scent stronger than that of Comparative Example 5 was obtained in Example 5 after 1 minute of wiping. Further, after wiping 3 to 20 minutes, in Example 5, the scent was stronger than that in Comparative Example 5, that is, the scent remained strong over time. From this, it was found that Example 5 was superior to Comparative Example 5 in terms of aromatic strength derived from the fragrance and durability. In particular, in addition to realizing the desired fragrance derived from the fragrance at the time of use or immediately after use, it is possible for the user to feel the desired fragrance more than before even after a certain period of time after use. Increase satisfaction. From this, it turned out that according to the composition of Example 5, the satisfaction of the user can be further enhanced.

Moreover, as is clear from Table 6, also in the nonwoven fabric, a stronger scent was obtained in Example 5 than in Comparative Example 5 after 1 minute. Further, after 5 to 30 minutes, in Example 5, the scent was stronger than that in Comparative Example 5, that is, the scent remained strong over time. From this, it was found that Example 5 was superior to Comparative Example 5 in the non-woven fabric in terms of aromatic strength derived from the fragrance and sustainability.

For this reason, according to the present invention, it is possible to obtain a composition for external use that is superior in deodorizing action and the like.

Test example 4
The nonwoven fabric R was impregnated with 3.2 g of the composition of Example 5 and Comparative Example 5 and quickly contained in the package. One day after the housing, the nonwoven fabric was taken out from the package, and for 4 subjects, wiped off in the same manner using Example 5 on the lower ear of one neck and Comparative Example 5 on the lower lower ear. The strength of the refreshing sensation after 1, 3, 5, 7, 10, 13, 15 and 20 minutes was evaluated in the following five stages, and the average value was obtained (room temperature (20 to 23 ° C.), humidity 40-45%). The larger the value, the stronger the coolness of the example. In addition, as apparent from Table 3, the composition for external use used in this test example contains menthol.
<About refreshing feeling>
5: The example clearly has a refreshing feeling compared to the comparative example 4: The example has a slightly strong refreshing feeling compared to the comparative example 3: The example has the same refreshing feeling compared to the comparative example 2: Comparison Table 7 shows the results in which the refreshing feeling of the example is slightly weaker than that of the example.

As is clear from Table 7, in Example 5, a stronger refreshing sensation derived from menthol than in Comparative Example 5 was obtained over time. From this, it was found that Example 5 was superior to Comparative Example 5 in terms of refreshing strength and sustainability. Therefore, according to the present invention, it is possible to obtain a composition for external use which is further excellent in a refreshing action and a refreshing action.

Test Example 5
The forearms of both subjects' 6 hands were lightly washed with warm water and then rested for 10 minutes. The composition for external use shown in Example 6 and Comparative Example 6 in Table 8 was housed in a spray container to prepare a test preparation. The composition for external use contains menthol as a cooling agent. The obtained preparation was sprayed onto the forearm by 30 pushes and spread with rubber gloves. At this time, Example 6 was applied to one forearm, and Comparative Example 6 was applied to the other forearm. By wearing rubber gloves and spreading, different formulations that could adhere to the hands were prevented from being applied to the forearm. Thereafter, the refreshing feeling was evaluated by the following procedure. The measurement environment was 21 to 23 ° C. and the relative humidity was 45 to 60%.

The strength of the refreshing sensation when 10 seconds after coating and 3, 5, 8, 10, 15, 20, 25, and 30 minutes after coating was evaluated in the following five stages, and the average value was obtained.
<About refreshing feeling>
5: Feeling a refreshing feeling 4: Between “feeling clearly” and “feeling” 3: Feeling a feeling of cooling 2: Between “feeling faint” and “feeling” 1: Feeling a faint feeling of cooling 0: Feeling of cooling The results are shown in FIG. As is clear from FIG. 1, in Example 6, a stronger refreshing feeling derived from menthol than in Comparative Example 6 was obtained over time. From this, it was found that Example 6 was superior to Comparative Example 6 in terms of refreshing strength and durability.

Further, although not shown in the results, discomfort was also evaluated in five stages. As a result, good evaluation that no discomfort was felt in Example 6 was obtained.

As described above, from the results of Test Examples 1 to 5, by using diethoxyethyl succinate in combination, the effect derived from IPMP, the strength and durability of the fragrance derived from the fragrance, and the refreshing feeling derived from the cooling agent. It was observed that strength and sustainability could be improved.

Claims

A composition for external use containing diethoxyethyl succinate and at least one selected from the group consisting of a refreshing agent, a fragrance and cymen-5-ol.
The external composition according to claim 1, wherein the external composition is a liquid composition.
The external composition according to claim 1 or 2, wherein the external composition contains 0.01 to 10% by weight of diethoxyethyl succinate.
The external composition according to any one of claims 1 to 3, wherein the external composition contains 0.01 to 7% by weight of a refreshing agent.
The composition for external use according to any one of claims 1 to 4, which contains 0.01 to 1.5% by weight of a fragrance in the composition for external use.
The external composition according to any one of claims 1 to 5, wherein the external composition contains 0.01 to 0.2% by weight of cymene-5-ol.
The composition for external use according to any one of claims 1 to 6, comprising 1 to 500 parts by weight of diethoxyethyl succinate with respect to 1 part by weight of cymene-5-ol in the composition for external use.
The external composition according to any one of claims 1 to 7, further comprising 2 to 70% by weight of a lower alcohol in the external composition.
The composition for external use according to any one of claims 1 to 8, which is a composition for external use for sterilization, deodorization, refresh or refreshing.
The composition for external use according to any one of claims 1 to 9, wherein the refreshing agent is at least one selected from the group consisting of menthol, menthol derivatives, camphor, peppermint oil and peppermint oil.
An external product comprising a carrier and / or a container and the external composition according to any one of claims 1 to 10, wherein the external composition is supported on the carrier and / or contained in the container.
The external product according to claim 11, wherein the carrier is a nonwoven fabric.
A method for improving the strength and / or sustainability of a cooling agent, comprising using diethoxyethyl succinate and a cooling agent in combination.
The method according to claim 13, wherein diethoxyethyl succinate and a cooling agent are used in combination and supported on a support and / or contained in a container.
A method for improving the strength and / or sustainability of fragrance derived from a fragrance, characterized by using diethoxyethyl succinate and a fragrance.
The method according to claim 15, wherein diethoxyethyl succinate and a fragrance are used in combination and supported on a carrier and / or contained in a container.
A method for improving the action of cymene-5-ol, comprising using diethoxyethyl succinate and cymene-5-ol in combination.
The method according to claim 17, wherein diethoxyethyl succinate and cymene-5-ol are used in combination and supported on a support and / or contained in a container.