TW201236689A - Agent to suppress old person smell, containing oolong tea extract and/or chinese blackberry tea extract - Google Patents

Abstract

The problem addressed by the present invention is the provision of a deodorant for the suppression of body odor, particularly the "old person smell" which is inherent to people of middle- and old-age, the deodorant being safe to use and having a strong deodorizing effect. By having the agent contain oolong tea extract and/or Chinese blackberry tea extract as active ingredients, it is possible to deodorize unsaturated aldehydes, which are the main cause of "old person smell".

Description

201236689 VI. Description of the invention: [Technical field to which the invention belongs] The present invention relates to an old-age odor inhibitor. More specifically, the present invention relates to an aged odor inhibitor which contains an oolong tea extract and/or a sweet tea extract as an active ingredient and has an excellent deodorizing effect on a substance of aging odor. Further, the present invention relates to a composition comprising an oolong tea extract and a sweet tea extract, and further comprising a green tea extract and/or a red persimmon fruit extract. [Prior Art] In recent years, various deodorants, deodorants, or fragrances have been developed by consumers who are pursuing a more comfortable living space with an increase in price or demand. In addition, consumers' concern for body odor has also increased, and the demand for products having deodorizing effects has increased in recent years. Among the body odors, the so-called "old-age odor" which is mainly caused by the odor of the middle-aged people is known to be deeply related to the unsaturated aldehyde such as octenal or decenal. In detail, it is known that 9-hexadecenoic acid (palmitoic acid) which is increased in sebum of the middle and high age layers is oxidized, decomposed by peroxidized lipids, or is decomposed by the skin often causing bacteria to occur. Terpene aldehyde of malodorous substance (Patent Document 1). As a technique for removing aging odor, a method of masking and coating the unsaturated aldehyde generated by the coating (Patent Document 1) and a method of capturing with ethanolamine (Patent Document 2) are disclosed. Further, it is disclosed that a method of suppressing the generation of odor in the sebum which is a cause of aging odor is suppressed. Specifically, it discloses that inhibition of oxidation by an antioxidant (Patent Document 3), inhibition of lipid peroxidation by a lipid-5-201236689 oxygenase inhibitor (Patent Document 4), and inhibition of participation in fatty acid production by an antibacterial agent The skin is often proliferated (Patent Document 5), and a method of suppressing the occurrence of unsaturated aldehydes. On the other hand, the oolong tea extract is known to have a deodorizing effect on the odor in the oral cavity (Patent Document 6). Further, regarding the sweet tea extract, it is known that the SH compound such as methyl mercaptan has a deodorizing effect (Patent Document 7). However, the deodorizing effect of the unsaturated aldehyde of the old stinky substance is unknown. In general, it is known that the material or composition of the deodorizing effect is not necessarily effective for all the odor components, and the current situation is to develop a deodorizing product that responds to the odor component. [PRIOR ART DOCUMENT] [Patent Document 1] Japanese Laid-Open Patent Publication No. JP-A No. Hei. No. Hei. [Patent Document 5] Japanese Laid-Open Patent Publication No. Hei No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. [Claim No. 3633634] [Summary of the Invention] Although the problem to be solved by the invention is as described above in the report on the countermeasures for the elderly, it is expected to be

S -6- 201236689 The high deodorizing effect of saturated aldehydes, and even the use of a deodorant with high safety such as human body. The present invention has been made in an effort to solve the aforementioned problems, and to provide an anti-aging odor suppressant having a high deodorizing effect and an anti-aging effect, or a composition having a deodorizing effect. Solution to the problem As a result of repeated efforts by the present inventors, it has been found that the oolong tea extract or the sweet tea extract has a significant deodorizing effect on the unsaturated aldehyde of the aged odor-causing substance, and the present invention has been completed. That is, the present invention relates to the following, but is not limited thereto. (1) An odor suppressant containing an oolong tea extract and/or a sweet tea extract as an effective ingredient. (2) The extract is an old-age odor inhibitor described in (A) of an aqueous solvent extract. (3) The odor component is an aged odor inhibitor described in (1) or (2) of the unsaturated aldehyde. (4) The unsaturated aldehyde is an old-age odor inhibitor described in (3) of nonenal or octenol. (5) An old-age odor inhibitor according to any one of (1) to (4), which further comprises a green tea extract and/or a red persimmon fruit extract. (6) A composition for deodorization obtained by blending the aged odor suppressing agent according to any one of (1) to (5). (7) The composition for deodorization described in (6) of the external preparation for skin. 201236689 (8) Contains oolong tea extract and sweet tea extract' and then contains green tea extract and/or red persimmon fruit extract. (9) The composition described in (8) for deodorization (1) The composition described in (8) or (9) for the external preparation for skin. EFFECTS OF THE INVENTION The present invention provides an old-fashion inhibitor containing an oolong tea extract and/or a sweet tea extract as an active ingredient and having an excellent deodorizing effect on an old-age odor-causing substance. The aged odor inhibitor of the present invention can be blended with a deodorant composition for the purpose of suppressing the effect of aging odor. Further, in another aspect of the present invention, a composition containing an oolong tea extract and a sweet tea extract and containing an extract of green tea extract and/or red persimmon fruit, which has an excellent deodorizing effect, can be provided. BEST MODE FOR CARRYING OUT THE INVENTION The aged odor inhibitor of the present invention is characterized by containing an oolong tea extract and/or a sweet tea extract as an active ingredient. The aged odor inhibitor of the present invention is intended to provide deodorization of an aged odor which is accompanied by an old age, and particularly provides deodorization of an unsaturated aldehyde (nonenal, octenal, etc.) which is a substance causing age odor. Agent. Hereinafter, the embodiment of the present invention will be described in detail. <Oolong Tea Extract, Sweet Tea Extract> (1) Oolong Tea

S -8- 201236689 Oolong tea is obtained by semi-fermenting the leaves of Camellia sinensis of Camellia. Even if it is usually consumed, the difference in the flavor is obvious. Different from the black tea or green tea with different manufacturing methods or steps, the composition of the extract is greatly different. The oolong tea is heated in the middle of the tea fermentation, and the fermentation is stopped to make the semi-fermentation production. The preparation of the oolong tea leaves can be carried out by any method known to the manufacturer. The tea leaves can be prepared by steps such as drying, semi-fermentation, mashing, and the like. Further, the tea leaves can be pulverized before the extraction step. This drying and pulverizing step can be carried out by a method known to a related art, and the order and the number of times are not particularly limited. The drying method is not particularly limited, and a known drying method can be used, and examples thereof include a method of heat drying, drying by the sun, drying by dehumidification, freeze drying, and the like. Further, the pulverization step is not particularly limited, and the raw leaves may be wet-pulverized or the dried leaves may be dry-pulverized. Further, the size of the tea leaves or the powder thereof is not particularly limited, but may be appropriately set in consideration of ease of handling, extraction efficiency, ratio of extract components, and the like. (2) Sweet Tea Sweet tea is a plant of the genus Rubus, which has been used as a sweet tea in China since ancient times. The scientific name is Rubus suavissimus. The sweet tea can be extracted from leaves or stems thereof, especially the leaves are dried as a raw material. Modulation of sweet tea leaves can also be carried out according to methods known to the relevant industry. In general, sweet tea is made by drying the leaves in the sun. Tea leaves can be prepared by steps such as drying, semi-fermentation, and mashing. In addition, the tea leaves can be comminuted before the extraction step. This drying and pulverizing step can be carried out according to a method known to a related art, and the order and number of times are not particularly limited. The drying method is not particularly limited to -9-201236689. A known drying method can be used, and examples thereof include a method of heat drying, drying by the sun, drying by dehumidification, freeze drying, and the like. Further, the pulverization step is not particularly limited, and the raw leaves may be wet-pulverized or the dried leaves may be dry-pulverized. Further, the size of the tea leaves or the powder thereof is not particularly limited, but may be appropriately set in consideration of ease of handling, extraction efficiency, ratio of extract components, and the like. (3) Extraction Extraction of oolong tea or sweet tea can be carried out according to methods known to the relevant industry. For example, the tea leaves can be extracted by appropriately heating the tea leaves in an extraction solvent to obtain an extract. Further, the oolong tea and the sweet tea extract may be solid or liquid 〇. The extraction solvent used in the extraction step is not particularly limited. For the solvent to be used for the extraction, for example, water alone (including hot water in the case of water), water and one or more kinds of polar solvents (lower alcohol such as methanol or ethanol, lower ketone such as acetone, polyhydric alcohol, etc.) may be used. Any mixed solvent or the like. From the viewpoint of efficiently obtaining an extract having a high deodorizing effect, it is preferred to carry out extraction with an aqueous water-based solvent. Further, from the viewpoint of safety, it is particularly preferable to use water, ethanol, or a mixed solvent of these. Next, the polar solvent to be mixed with water is preferably 90% by volume or less. The ratio of the oolong tea leaves to the extraction solvent in the extraction step is not particularly limited, but is preferably from 2 to 1,000 times by weight based on 1 part of the tea leaves. When considering the extraction operation or efficiency, it is preferably 5 to 100 times by weight. Further, the ratio of the sweet tea leaves to the extraction solvent in the extraction step is not particularly limited, but it is preferably a solvent having a weight ratio of 2 to 1 〇 〇 based on 1 part of the tea leaves. When considering the extraction operation or efficiency, it is particularly preferable to use 5 to 1 Torr.

S -10- 201236689 The extraction temperature is also not particularly limited and can be carried out at a solvent boiling point from room temperature to atmospheric pressure, but it is convenient to carry out the operation at room temperature. Further, from the viewpoint of extraction efficiency, it is preferred to carry out extraction with a heated aqueous solvent, for example, at 70 to 100 ° C, preferably with 90 toloo. In addition, the extraction time of the oolong tea can be appropriately determined, but it is preferably in the range of 10 seconds to 24 hours. The extraction time for sweet tea can also be appropriately determined, but it is preferably in the range of 10 minutes to 24 hours. In addition, when extracting, the viewpoint of improving the extraction efficiency and the like may be added, and other components may be added. The dried or concentrated form of the extract can be obtained by following the steps of the filtration step, the sterilization step, the drying step or the concentration step, if necessary. From the viewpoint of preservability and safety, it is preferred to remove the dry state of the solvent. Dry extracts can be carried out by methods known to those skilled in the art. Further, in the present invention, the oolong tea extract or the sweet tea extract also contains a leaf pulverized product. The active ingredient of the oolong tea or sweet tea source is derived from the ingredients of each leaf, and the extraction step is not necessary as long as it contains the form of such active ingredients. <Old-age odor inhibitor> The odor inhibitor of the present invention contains oolong tea extract and/or sweet tea extract as an active ingredient, and may further contain a composition of green tea extract and/or red persimmon fruit extract as an active ingredient. . The aged odor suppressing agent of the present invention can be used for the odor including the so-called aged odor, and particularly for the deodorizing effect of the unsaturated aldehyde. Examples of the unsaturated aldehyde include a nonenal or an octenal. -11 - 201236689 In addition, the old-age odor inhibitor of the present invention can be used for body odor including odor of old age (bad smell, foot odor, sweat odor, scalp odor, bad breath, etc.), and can also be used indirectly affected by old-age odor. Odor in the interior and in the car and in the toilet, smell of clothes, smell of shoes, etc. Older odor inhibitors can also be used after being held in a carrier. Examples of the carrier include gels such as cold weather, gelatin, carrageenan, and gum arabic, gels such as polyvinyl alcohol and polypropylene decylamine, fibers such as various celluloses, zeolites, porous glass, ceramics, and active agents. Porous materials such as carbon, cerium oxide, and ceric acid. The aged odor inhibitor of the present invention may be directly used as an oolong tea extract and/or a sweet tea extract, or may be blended with other ingredients as a deodorizing composition. In particular, an extract or a pulverized product obtained from a plant material such as green tea, red persimmon fruit, scutellaria, primrose, sugar cane or the like may be further added to add the green tea extract and/or the red persimmon fruit extract. Further, the aged odor inhibitor of the present invention can be used in a state in which the carrier is carried. Further, it may be dissolved or dispersed in a solvent such as water. Here, the preparation of the green tea extract and/or the red persimmon fruit extract can be carried out according to any method known to the relevant industry. For example, the green tea extract can be obtained by extracting non-fermented tea leaves of Camellia sinensis from Camellia, using water, hot water, aqueous solvent, and the like. The dry-type or concentrated-type extract can be obtained by following the steps of the filtration step, the sterilization step, the drying step or the concentration step, as needed. Further, the persimmon fruit extract is obtained from, for example, red persimmon liquid obtained from the fruit of Diospyros kaki Thunberg (Ebenaceae). Here, the aforementioned green tea extract and red persimmon

S -12- 201236689 Fruit extracts can be solid or liquid, and also contain powders of leaves or fruits. The extraction step is not necessary as long as it contains the form of the active ingredient from the green tea and red persimmon fruit. The total content of the oolong tea extract and/or the sweet tea extract in the old-age odor inhibitor, and the total extract of the green tea extract and/or the red persimmon fruit extract, as the case may be, is not particularly limited, but is converted in dry weight. It is preferably 0.001~1 〇〇% by weight in the old-age odor inhibitor, preferably 〇~60% by weight, preferably 0. 5~10% by weight. The blending amount of each extract is not particularly limited, and for example, three kinds of oolong tea extract and sweet tea extract are used, or three kinds of green tea extract and/or red persimmon fruit extract are added thereto or In the case of the four kinds of extracts, the blending ratio of the extracts in each combination is not particularly limited, but may be blended separately so that the dry weight of the other extracts becomes 1 to 1 based on the dry weight of the extract having the least amount of the extract. 0 times the amount, preferably 1 to 5 times, more preferably 1 to 2 times. The components contained in the oolong tea extract and/or the sweet tea extract blended in the aged odor inhibitor of the present invention, or the components of the red blended green tea extract and/or the red persimmon fruit extract are not particularly limited. The main components of the extract are polyphenols. The term "polyphenols" is a generic term for a compound having a plurality of phenolic hydroxyl groups in one molecule, and is not particularly limited, and is extracted from eucalyptus, flavonoids, catechins, etc., such as oolong tea, sweet tea, green tea, and the like. . <Deodorizing composition> -13-201236689 One type of the present invention is a deodorizing composition obtained by blending the above-mentioned aged odor inhibitor. As a form of the composition for deodorization, it is preferably used as a skin external preparation. For example, facial cleanser, soap, oral care products (mouthwash, toothpaste, etc.), shampoo, moisturizing essence, hair lotion, hair cream, hair dressing, hair growth, long hair and hair growth agent, Lotions, lotions, creams, etc. The blending amount of the aged smell suppressing agent in the composition for deodorizing is not particularly limited, and is 〇. 0 1 to 9 5 wt%, and 0. 〇1 to 70 wt% is preferably '0.1 to 20 by weight. % is especially good. In addition, for example, the total blending amount of the oolong tea extract and/or the sweet tea extract, or the total blending amount of the total extract when the green tea extract and/or the red persimmon fruit extract are further blended in the composition, The odor suppressant may be blended in an amount of 0.0001 to 90% by weight, preferably 0.005 to 50% by weight, particularly preferably 0.001 to 10% by weight, based on the dry weight of the composition. The blending amount of each extract in the composition for deodorizing of the present invention is not particularly limited as long as it is based on the blending ratio of the extract in the aged odor inhibitor, for example, two kinds of oolong tea extract and sweet tea extract are used, respectively. When three or four kinds of extracts selected from the green tea extract and/or the red persimmon fruit extract are added to the mixture, the blending ratio of the extract in each combination is not particularly limited, but the extract is the least amount. The dry weight may be blended so as to make the dry weight of the other extracts 1 to 10 times, preferably 1 to 5 times, more preferably 1 to 2 times. Further, the deodorant composition containing the aged odor inhibitor of the present invention may be blended with other components or additives within a range not impairing the effects of the present invention. As such components or additives, oils and fats such as vegetable oils and sheep can be cited.

S -14- 201236689 Waxes, hydrocarbons, fatty acids, higher alcohols, esters, various surfactants, moisturizers, whitening agents, pigments, colorants, pigments, sweeteners, nutritional supplements, etc. , spices, vitamins, amino acids, plant and animal extracts, UV absorbers, antioxidants, antiseptic and fungicides. Among them, a butanediol which is known to have a moisturizing action or an antibacterial action can be suitably blended. The aged odor inhibitor of the present invention may also be blended alone or in combination with other deodorizing ingredients. The deodorizing component which can be used is not particularly limited. For example, a known masking agent, adsorbent or porous material can be mentioned. Further, in order to further enhance the effect of suppressing old-age odor, a known deodorant for old-age odor, such as an antioxidant, a lipoxygenase inhibitor, an antibacterial agent, a masking and coating conversion flavor, ethanolamine or the like can be used in combination. <Composition> As another form of the present invention, an oolong tea extract and a sweet tea extract, and a composition of an extract of any one or both of the green tea extract and the red persimmon fruit extract may be further included. The compositions of the present invention may also incorporate other ingredients. In particular, the composition can be used as a composition for deodorization. The total blending amount of the oolong tea extract and the sweet tea extract, and the green tea extract and the red persimmon fruit extract in the composition of the present invention are not particularly limited. In terms of dry weight, the blending ratio is 0.0001 to 90% by weight, preferably 0.005 to 50% by weight, more preferably 0.001 to 1% by weight. The blending amount of each extract in the composition of the present invention is not particularly limited, but oolong tea extract and sweet tea extract are used, or -15-201236689 green tea extract and/or red persimmon fruit extract are added thereto. In the case of three or four kinds of extracts, the blending ratio of the extracts in each combination is not particularly limited, but may be separately blended to make the dry weight of the other extracts based on the dry weight of the extract having the least amount. It is preferably 1 to 10 times, preferably 1 to 5 times, more preferably 1 to 2 times. The composition in one form of the present invention is preferably used as an external preparation for skin. For example, facial cleanser, soap, oral care products (mouthwash 'toothpaste, etc.), shampoo, moisturizing essence, hair lotion, hair cream, hair dressing, hair growth lotion, long hair and hair growth agent, Lotions, lotions, creams, etc. Further, the composition in one form of the present invention may be blended with other components or additives within the range not impairing the effects of the present invention. Examples of such components or additives include extracts or pulverized materials obtained from plant materials such as sassafras, evening primrose, and sugar cane, oils and fats such as vegetable oils, waxes such as lanolin or bee stings, hydrocarbons, fatty acids, and higher alcohols. , esters, various surfactants, moisturizers, whitening agents, pigments, colorants, pigments, sweeteners, nutritional supplements, flavors, vitamins, amino acids, plant and animal extracts, UV absorbers, antioxidants 'Antiseptic and fungicides, etc. A butanediol in which a moisturizing action or an antibacterial action is known can be suitably blended. Further, the deodorizing component which can be used is not particularly limited, and examples thereof include a known shielding agent, an adsorbent, and a porous material. Further, a known deodorant for old age, such as an antioxidant, a lipoxygenase inhibitor, an antibacterial agent, a masking and coating conversion flavor, ethanolamine or the like can be used. [Embodiment]

S -16 - 201236689 EXAMPLES Hereinafter, the present invention will be described in detail based on examples, but the present invention is not limited thereto. [Example 1] Deodorization effect test on unsaturated aldehyde ι (functional evaluation) &lt;Test method&gt; • Evaluation sample As an oolong tea extract, a commercially available cosmetic material containing oolong tea extract as a main component (using oolong tea extraction) was used. Liquid BG (Jiushan Pharmaceutical Co., Ltd.). As a sweet tea extract, a commercial cosmetic raw material (sweet tea extract BGW (made by Jiuji Pharmaceutical Co., Ltd.)) containing sweet tea extract as a main component is used. 'As a green tea extract, a commercially available cosmetic raw material containing green tea extract as the main ingredient (and ism green tea (made by Jiuji Pharmaceutical Co., Ltd.)) is used as the extract of red persimmon fruit, mainly using red persimmon fruit extract. Commercially available cosmetic ingredients (Pancil BA-210-1, manufactured by Rilis Scientific Industries Co., Ltd.). As a comparative example, the three plant extracts used as deodorants were tested. Commercially available cosmetic raw material (Ougonliquid B, manufactured by PHARCOS), which is the main ingredient, is commercially available as a scutellaria extract, with evening primrose extract as its main ingredient. Cosmetic raw materials (Luna white B, IX PHARCOS) are used as evening primrose extracts, and commercially available cosmetic raw materials (sugar cane extract MSX-245, manufactured by Mitsui Sugar Co., Ltd.) containing sugar cane extract as the main component -17- 201236689 • Operate 20 ml of the aforementioned oolong tea extract 'sweet tea extract, green tea extract, red persimmon fruit extract, astragalus extract, evening primrose extract and sugar cane extract in each vial. Add 0.5% of 5% hydrazine aldehyde (trans-2-nonenal (first grade, Wako Pure Chemical Industries Co., Ltd.) to olive squalane (NIKKOL refined olive squalane, Nikko Chemicals Co., Ltd.) The dilute was quickly sealed with a rubber stopper. After standing at 40 ° C for 10 minutes, the sensory evaluation was performed. <Results> As shown in Table 1 below, 'Oolong tea extract, sweet tea extract And the green tea extract is compared with the astragalus extract, the evening primrose extract, the sugarcane extract, and the no-addition, which shows that the deodorization effect of the nonenal is good. In addition, it is confirmed that the red persimmon fruit extract also has Deodorization effect.

[Table 1] Evaluation sample nonenal odor oolong tea extract 〇 sweet tea extract 〇 green tea extract 〇 red persimmon fruit extract Δ Astragalus extract Δ evening primrose extract Δ sugar cane extract Δ no added X 〇: high deodorization Effect △: only a little deodorizing effect X: almost no deodorizing effect

S -18-201236689 [Example 2] Deodorization effect on unsaturated aldehyde Test 2: For the oolong tea extract, the sweet tea extract and the green tea extract used in Example 1, the deodorization of the unsaturated aldehyde was carried out according to the method described later. Effect test. Further, the reduction rate was evaluated by high performance liquid chromatography using nonenal as an unsaturated aldehyde. &lt;Test method&gt; • Test drug and appliance scent bag (25cmx40cm) [Miyakovinyl Processing Co., Ltd.] Terpene gas: use occurs from trans-2-nonenal (Grade 1) [Wako Pure Chemical Industries Co., Ltd. ]gas.

DNPH-adsorbent tube (DNPH-Cartridge): GL-Pak mini AERO DNPH [GL Sciences Co., Ltd.] • Evaluation sample used as an evaluation sample of Example 1 oolong tea extract, sweet tea extract, green tea extract, and as a control Water. • Operation Place the evaluation sample and water in the scent bag separately, apply heat seal, enclose 4L of air, and add the decene gas to make the set gas concentration. The solution was allowed to stand, and the gas in the bag was collected in a DNPH-adsorption tube every other time (0, 30, 60, and 180 minutes). 5 ml of acetonitrile was passed through a DNPH-adsorbing tube for trapping gas to dissolve the DNPH derivative. The eluate was measured by high performance liquid chromatography to calculate the gas concentration in the bag. High performance liquid layer -19- 201236689 The operating conditions of the analyzer are shown below. • Operating conditions of high performance liquid chromatography: LC-2010AHT [Shimadzu Corporation] Detector: UV spectrophotometer column: RP-Amide, φ 4.6mmx25cm [Sigma-Aldrich Japan Co., Ltd. ]

Column temperature: 40 °C Eluent: a mixture of acetonitrile and water (acetonitrile·water = 80: 20) Eluent flow: 1.5 ml/min Measurement wavelength: 360 nm Injection volume: 4 0 /z 1 • Test Condition sample usage: 5 ml of evaluation sample (each extract), 5 ml of control (water) Test object gas: nonenal (initial gas concentration: 22 ppm) Room temperature: room temperature &lt;Results&gt; As shown in Fig. 2, compared with the control, the oolong tea extract, the sweet tea extract and the green tea extract have a large reduction rate of the unsaturated aldehyde, and exhibit an excellent deodorizing effect.

S -20- 201236689 [Table 2] Evaluation of sample reduction rate (%) — Elapsed time (minutes) 0 30 60 180 Oolong tea extract 0 77 82 82 Sweet tea extract 0 73 77 82 Green tea extract 0 65 70 80 Control (water ) 0 32 36 45 * Reduction rate (%) = 100 - [perylene aldehyde concentration after each elapsed time (after 30, 60, 180 minutes) / [perylene concentration of elapsed time (0 points)] X100 [Implementation] Example 3] Deodorizing effect on unsaturated aldehydes Test 3: Using a commercially available raw material oolong tea extract Μ powder (manufactured by Jiuji Pharmaceutical Co., Ltd.) to remove a sample of dextrin as an oolong tea extract, a commercially available raw sweet tea extract Μ powder (Jiushan Pharmaceutical Co., Ltd.) as a sweet tea extract, dissolved at 25 ° /. The ethanol solution was made to have a concentration of 1〇〇11^/„11 as an evaluation sample. The deodorization effect test on the unsaturated aldehyde was carried out according to the method described later. In addition, the use of the nonenyl aldehyde as the unsaturated aldehyde was carried out by the high-efficiency liquid. The phase chromatography 'analysis was carried out under the same conditions as in Example 2 to evaluate the reduction rate. <Test method> In addition to using 5 ml of each of the oolong tea extract and the sweet scorpion extract prepared by the aforementioned method, water was used as an evaluation sample. And a 25% ethanol solution was used as a control. The deodorization evaluation test was carried out in the same manner as in Example 2. The initial gas concentration of the test gas (nonenal) was 2 〇ppm.

S -21 - 201236689 As shown in Table 3 below, the oolong tea extract and the sweet tea extract have a large reduction rate of unsaturated wake-up compared with the control, and show a good deodorizing effect. [Table 3] Evaluation of sample reduction rate (%) Elapsed time (minutes) 0 30 60 180 Oolong tea extract 0 70 70 75 Sweet tea extract 0 60 65 65 Control (25% ethanol solution) 0 45 50 50 Control (water) 0 25 30 35 ※Reduction rate (%) =100—[Each elapsed time (after 30, 60, 180 minutes)

Decene aldehyde concentration] / [eperental concentration of elapsed time (〇)] xlOO

[Example 4] Deodorizing effect on unsaturated aldehydes Test 4: &lt;Test method&gt; • Evaluation sample Using commercially available raw material oolong tea extract Μ powder (manufactured by Jiuji Pharmaceutical Co., Ltd.) to remove dextrin samples as oolong tea The extract is a commercially available raw sweet tea extract Μ powder (manufactured by Jiuji Pharmaceutical Co., Ltd.) as a sweet tea extract. Further, a commercially available powder raw material (Pancil PS-M (manufactured by Rilis Scientific Industries Co., Ltd.)) was used as the red persimmon fruit extract. Commercially available tea extract powder (tea extract MF (made by Jiu-Shan Pharmaceutical Co., Ltd.)) is used as a green tea extract, respectively, as a reagent. The mixture of the same weight of the oolong tea extract, sweet tea extract, dissolved in A 25% ethanol solution was used to make the total amount of the extract into a concentration of 100 mg/ml, and an evaluation sample of the two mixed samples was prepared. Similarly, mixing

S -22- 201236689 The same amount of the above-mentioned oolong tea extract, sweet tea extract and green tea extract are dissolved in 25% ethanol solution to make the total amount of the extract into a concentration of 100 mg/ml, and three kinds of mixed extracts are prepared. (1) Evaluation sample. - Further, the oolong tea extract, the sweet tea extract, and the red persimmon fruit extract are mixed so that the weight of each powder is 1:1: 3.7, dissolved in a 25% ethanol solution, and the total amount of the extract is adjusted to a concentration of 100 mg/ml. Evaluation samples of 3 mixed extracts (2). Further, the oolong tea extract, the sweet tea extract, and the red persimmon fruit extract are mixed, and the weight of each powder is 1:1:1:3.7, dissolved in a 25% ethanol solution, so that the total amount of the extract becomes a concentration of 100 mg/ml. An evaluation sample of the four mixed extracts was prepared. • Operation In the same manner as in Example 2 except that the above two kinds of the mixed extracts were used as the evaluation sample and water (5 ml) as a control, the deodorization evaluation test for the unsaturated aldehyde was carried out. Further, the reduction rate was evaluated by the same conditions as in Example 2 using a nonenyl aldehyde as an unsaturated aldehyde by high performance liquid chromatography. Further, the initial gas concentration of the test gas (nonenal) was 2 Oppm. &lt;Results&gt; As shown in Table 4 below, the reduction of the unsaturated aldehydes was compared with the control of the two kinds of the mixed extracts, the three kinds of the mixed extracts (1) and (2), and the four kinds of the mixed extracts. The rate is large, showing good deodorizing effect.

S -23- 201236689 [Table 4] Evaluation of sample reduction rate (%) Elapsed time (minutes) 〇30 60 180 2 kinds of mixed extracts (oolong tea, sweet tea) 0 65 70 7 5 3 kinds of mixed extracts (1) (Oolong tea , sweet tea, green tea) 〇61 67 67 3 kinds of mixed extracts (2) (Oolong tea, sweet tea, red persimmon fruit) 0 72 83 94 4 kinds of mixed extracts (Oolong tea, sweet tea, green tea, red persimmon fruit) 〇65 75 85 Control (25% ethanol solution) 〇45 50 50 [Example 5] Deodorization effect on unsaturated aldehydes Test 5: Mixed extraction of combined oolong tea extract, sweet tea extract, green tea extract, and persimmon extract The liquid (hereinafter referred to as an anti-decene aldehyde Pc (polyphenyl complex)) is used as an evaluation sample, and the deodorizing effect test on the unsaturated aldehyde is carried out according to the method described later. The anti-nonenal PC-based mixed blended oolong tea extract BG (made by Jiu-Sen Pharmaceutical Co., Ltd.), sweet tea extract BGW (made by Jiu-Sen Pharmaceutical Co., Ltd.), red persimmon fruit extract (r Pancil) manufactured by Rilis Science and Industry Co., Ltd., green tea extract (and isrn green tea (made by Jiushan Pharmaceutical Co., Ltd.) ), make the extract (The polyphenol is contained as a main component) is 1% by weight, and the amount of each extract is adjusted to be equal. Further, 'decene aldehyde is used as the unsaturated aldehyde, and the same as in Example 2 by high performance liquid chromatography. The rate of reduction is evaluated by conditional analysis. &lt;Test Method&gt;

-24-201236689 A deodorization evaluation test was carried out in the same manner as in Example 2, except that 5 ml of each of the allergic PCs prepared by the above method was used as an evaluation sample and water as a control. Further, the initial gas concentration of the test gas decene aldehyde was 20 ppm » &lt;Results&gt; The change in the concentration of the 2-nonenal concentration was as shown in Fig. 1, and the reduction rate of 2-nonenal was as shown in Table 5 below. Show. Compared with the control, the anti-nonenal PC has a large reduction rate of the unsaturated aldehyde, and shows a good deodorizing effect. [Table 5] Evaluation of sample elapsed time (minutes) 0 30 60 180 Anti-nonenal PC 0 60 85 85 Control (water) 0 25 25 35 * Reduction rate (%) = 100 - [Elapsed time (30, 60, Terpene concentration after 180 minutes] / [decene concentration of elapsed time (0 points)] X100 [Example 6] Confirmation test for the effect of the aged odor reduction effect: Modification of blending 1 · 〇 by weight of Example 5 The soap of anti-nonenal PC (hereinafter referred to as polyphenol soap) was used as an evaluation sample. Specifically, the polyphenol soap contains the anti-decene aldehyde PC (Oolong tea extract BG (made by Jiu-Sen Pharmaceutical Co., Ltd.), sweet tea extract BGW (made by Jiu-Sen Pharmaceutical Co., Ltd.), and red persimmon fruit extract (" "Pancil" by Rilis Science and Industry Co., Ltd.) 'Green tea extract ("and ism green tea" made by Jiu-Shan Pharmaceutical Co., Ltd.)

S -25- 201236689 and other additives. For the 20-year-old 75-75-year-old male who was worried about the old-age stench or the old-aged stench, the effect of reducing the old-age odor was evaluated by continuously using the aforementioned polyphenol soap for 4 weeks. The evaluation of the effect of reducing the odor of the elderly is based on the determination of the amount of 2-octene aldehyde in the body, the determination of the odor of the odor by the odor judge, and the three evaluation results of the subjective assessment of the odor by using the VAS (Visual analogue scale). &lt;Test method&gt; • Evaluation of sample polyphenol soap (blending 1.0% anti-decene aldehyde pc) • During the trial period from March 2011 to April 2011 • The tester was worried about the old-age stench or the 20 people who were accused of having an old-aged stench I am 43 years old to 75 years old (mean age: 59.2 ± 8.7 years old). The number of testers of all ages is shown in Table 6. In addition, for the testers, from the beginning to the end of the test, the use of healthy foods that are expected to reduce the effects of the old-age odor, the pharmaceutical products that are advertised as effects, and the external supplies and cosmetics of the Ministry of Medicine are prohibited, and the extreme violent gluttony is also controlled. [Table 6] Age (years) 4 0 ~ 4 9 50~59 6 0 ~ 6 9 70 ~ 79 Number of testers (name) 2 9 6 3 • Common operation

S -26- 201236689 Allow the tester to bathe daily during the test period, soak the sour soap with a bath towel during bathing, and wash all the body. The tester was wearing a t-shirt for 3 days, and washed the body before going to bed to wear a shirt. • Evaluation methods and evaluation results of each evaluation item (1) Measurement 2 - The amount of decal aldehyde is given to one sneaker every 3 days from the first 3 days of the inspection day, and 2 per sneakers are measured. - The amount of decal aldehyde. In addition, the measurement was carried out separately before the use of the fragrance, after 14 days of use, and after 28 days of use. Give a t-shirt for a cotton 10,000%, have been washed 'dehydrated' before drying. The tester wears a t-shirt to make direct contact with the skin, and wears pajamas on the t-shirt. The t-shirt that was taken off during the daytime was stored in a sealed state in a bag. The t-shirt was placed in a glass vacuum tray (15 L), and the air in the vacuum tray was passed through an activated carbon tube at 1 L/min to adsorb 2-nonenal, and the amount of 2-nonenal released from the t-shirt for 30 minutes was measured. The measurement was carried out using a GC/MS (gas phase chromatography mass spectrometer). &lt;Results> The change in the amount of 2_nonenal in the hair itself is shown in Fig. 2 . The amount of 2-nonenal extracted from the T-shirt worn on the bed after 3 days was compared with that before the use of the soap, and the use was reduced after 14 days and after 28 days of use. (2) Judging the odor of the old man by the odor judge -27- 201236689 Based on the 6-stage odor intensity expression (0: odorless, 1: barely sensible odor, 2: can be known as the faint smell of a certain odor, 3: odor which can be easily felt, 4: strong smell, 5: strong odor), and the odor judge determines the odor intensity of the old smell of the tester. Further, the odor level determined by the odor judge was performed before the use of the soap, after 14 days of use, and after 28 days of use. &lt;Results> The temporal change of the odor intensity of the aged by the odor judge was as shown in Fig. 3 . Based on the 6-stage odor intensity expression, the odor determinant judged the result of the sensation of the sensation of the sensation, and compared with the use before, it was meaningfully reduced after 14 days of use and after 28 days of use. (3) Using VAS (Visual analogue scale) to estimate the subjective smell of the old man on the 100mm straight line is "completely smellable (〇mm position)", and the other end is "very strong smell (100mm position)", The tester is allowed to record and evaluate the current state of the smell of the old-aged odor. In addition, the evaluation according to VAS was performed before the use of soap, after 1 day of use, after 14 days of use, and after 28 days of use. <Results> The time-dependent change of the subjective evaluation of the aged odor using VAS is shown in Fig. 4 . The VAS scale値 for the old-aged odor is compared with before use, using 1

S -28- 201236689 After a day, after 14 days of use and after 28 days of use, meaningful reduction ° &lt;Comprehensive results&gt; The results of the above evaluations (1) to (3) were confirmed, and it was confirmed by continuing to use the blended oolong tea extract. , sweet tea extract, green tea extract, persimmon extract of polyphenol soap to reduce the effect of old-age odor. [Production Example 1] A soap is a production example of a composition for deodorizing a oolong tea extract and/or a sweet tea extract, which will be described later. The blending amount of the raw materials is shown in Table 7. The soap material is mixed and stirred, and then each extract is added, and after mixing, it is molded. [Table 7] Raw materials Usage (parts by weight) Soap material 99.8 99.9 99.9 Oolong tea extract 0.1 0.1 Sweet tea extract 0.1 0.1 Total amount 100.0 100.0 100.0 [Production Example 2] Shampoo The blending amount of the raw materials is shown in Table 7. A preservative dissolved in 1,3-butanediol is added to the purified water. After mixing well, add sodium lauryl sulfate, coconut fatty acid monoethanolamine, then add the pigment, flavor and remaining hydrazine, 3-butanediol, add the extract -29-201236689, mix well and mix well. [Table 8] Raw material usage (parts by weight) Sodium lauryl sulfate 16.0 16.0 Coconut fatty acid monoethanol decylamine 4.0 4.0 1, 3-butanediol 1.9 1.9 Oolong tea extract 0.1 Sweet tea extract 0.1 Preservative, coloring matter, flavor Appropriate amount of purified water 78.0 78.0 Total amount 100.0 100.0 [Production Example 3] The blending amount of the hair conditioner raw material is shown in Table 9. (1) Add octadecyldimethylbenzylammonium chloride and salt to the purified water, and heat to 80 ° C to dissolve. (2) Separate stearyl alcohol, hydrogenated polyisobutylene and glyceryl monostearate, and warmed to 80 ° C to dissolve. (3) Stirring with a homogenizer (1), adding (2), and adding and stirring for 5 minutes. (4) After the completion of the preliminary stirring, the mixture was cooled to 50 ° C while stirring, and each of the extracts was added thereto, and further stirred and cooled to 35 ° C to prepare.

S -30- 201236689 [Table 9] Raw material usage (parts by weight) Octadecyldimethylbenzyl ammonium chloride 1.4 1.4 sesquisyl alcohol 4 4 Hydrogenated polyisobutylene 2 2 Monostearic acid glyceride 1.5 1.5 Salt 0.1 0.1 Oolong tea extract 0.1 Sweet tea extract 0.1 Refined water 90.9 90.9 Total amount 100.0 100.0 [Production Example 4] The blending amount of the hair growth liquid raw material is shown in Table 10. Salicylic acid, vitamin E and L-menthol dissolved in ethanol are added to the purified water, and dipotassium glycyrrhizinate dissolved in a portion of the purified water is added, and then each extract is added thereto, and uniformly mixed and prepared. [Table 10] Raw material usage (parts by weight) Ethanol 70.0 70.0 Vitamin E 0.4 0.4 L-menthol 0.4 0.4 Dipotassium glycyrrhizinate 0.1 0.1 Oolong tea extract 0.1 Sweet tea extract 0.1 Salicylic acid 0.5 0.5 Glycerol 0.5 0.5 Refined water 28.0 28.0 Total 100.0 100.0

-31 - 201236689 [Production Example 5] Spray The amount of the raw material to be mixed is shown in Table 11". Citric acid and sodium citrate were added and dissolved in purified water. Thereafter, a preservative dissolved in ethanol and polysorbate 80 were added. Thereafter, after each extract was added, the mixture was uniformly stirred and prepared. [Table 11] Raw material usage (parts by weight) Citric acid 0.01 0.01 Sodium citrate 0.09 0.09 Preservatives Appropriate amount of polysorbate 80 0.05 0.05 Ethanol 10.00 10.00 Oolong tea extract 1.0 Sweet tea extract 1.0 Refined water 88.85 88.85 Total 100.0 100.0 [Production Example 6] The blending amount of the lotion raw material is as shown in Table 12". Citric acid and sodium citrate were added and dissolved in purified water. Then, glycerin, 1,3-butanediol and trisodium ethylenediaminetetraacetate were added in this order, and then polyoxyethylene (18) oleyl ether dissolved in ethanol and vitamin E' were added to be stirred until homogeneous. Thereafter, each extract was added, and the mixture was uniformly stirred and prepared.

S -32- 201236689 [Table 12] Raw material usage (parts by weight) Glycerin 4.0 4.0 1, 3-butanediol 4.0 4.0 Ethanol 7.0 7.0 Polyoxyethylene (1 8 ) oleyl ether 0.5 0.5 Citric acid 0.05 0.05 Sodium citrate 0.1 0.1 Ethylenediaminetetraacetic acid trisodium 0.02 0.02 Vitamin E 0.50 0.50 Oolong tea extract 1.0 Sweet tea extract 1.0 Methylparaben 0.1 0.1 Refined water 82.7 82.7 Total amount 100.0 100.0 [Manufacturing Example 7] Blending amount of emulsion raw material As shown in Table 13. (1) Warming stearic acid, cetyl alcohol, octyldodecyl myristate and flowing paraffins to 8 (TC dissolved. (2) adding triethanolamine, sodium hyaluronate, glycerol, 1,3 - Butanediol and sodium edetate in purified water, warmed to 80 ° C. (3) Stir with a homogenizer (1), add (2), and add for 5 minutes after the addition. After the completion of the preliminary stirring, the mixture was cooled to 50 ° C, and each extract was added thereto, followed by cooling to 35 ° C to prepare.

-33- 201236689 [Table 13] Raw material usage (parts by weight) Stearic acid 1.5 1.5 Cetyl alcohol 0.5 0.5 Octyl lauryl myristate 5.0 5.0 Polyoxyethylene (10) monooleate 1.0 1.0 Flow Paraffin 5.0 5.0 Triethanolamine 0.5 0.5 Oolong Tea Extract 1.0 Sweet Tea Extract 1.0 Sodium Hyaluronate 0.01 0.01 Glycerol 7.0 7.0 1,3 - Butanediol 3.0 3.0 Sodium Ethylenediamine Triacetate 0.01 0.01 Refined Water 75.48 75.48 Total 100.0 100.0 [Production Example 8] The blending amount of the cream raw material is shown in Table 14. (1) warming stearic acid, glyceryl monostearate, sorbitan sesquisic acid, polyoxyethylene sorbitan monostearate, sesquisteal, hexahydroxystearic acid / stearic acid / rose acid) dipentaerythritol ester, olive oil, octyl dodecyl myristate and methyl polyoxyalkylene to 8 (rc dissolved ^ (2) added glycerin, I, 3 - butyl Alcohol, sodium hydroxide and methyl p-hydroxybenzoate in purified water, warmed to 80. (: Dissolved. (3) Stirred with a homogenizer (1), added (2), and then prepared for mixing 5 Minutes (4) After the completion of the stirring, 'cooling to 50 °C, adding each extract' and cooling to 35 r to prepare. -34- 201236689 [Table 14] __-- ' --^ Usage (parts by weight) Stearic acid 2.5 2.5 glyceryl monostearate 0.8 0.8 times sorbitan sorbitite 0.6 0.6 polyoxyethylene sorbitan monostearate 0.4 0.4 sesquisitol 2 2 triacontan 12.0 12.0 Hexa(hydroxystearic acid/stearic acid/rosmarinic acid) dipentaerythritol ester 2.0 2.0 olive oil 5.0 5.0 octyl dodecyl myristate 15.0 15.0 methyl polyoxane 0.5 0.5 Glycerin 10 10 1,3 - Butanediol 8.0 8.0 Sodium hydroxide 0.1 0.1 Methylparaben 0.1 0.1 Oolong tea extract 0.3 Sweet tea extract 0.3 Refined water 40.7 40.7 Total __________ 100.0 100.0 [Simplified illustration] Fig. 1] Fig. 1 shows the temporal change of the concentration of 2-nonenal. [Fig. 2] Fig. 2 shows the change with time of the amount of 2-nonenal extracted from the t-shirt worn by the tester. Fig. 3 shows the result of the odor of the old man who is judged by the odor. [Fig. 4] Fig. 4 shows the subjective evaluation result of the old odor using VAS-35-

Claims (1)

201236689 VII. Application for Patent Park: 1. An old-age odor inhibitor characterized by containing oolong tea extract and/or sweet tea extract as an active ingredient. 2. For example, the old-age odor inhibitor of the first application of the patent scope 'the above-mentioned extract is an aqueous solvent extract>> 3 · The old-age odor inhibitor of claim 1 or 2 of the patent scope, wherein the odor component is not Saturated aldehyde. 4. An old-age odor inhibitor as claimed in claim 3, wherein the unsaturated aldehyde is a nonenal or octenal. 5. The aged odor inhibitor according to any one of claims 1 to 4, which further comprises green tea extract and/or red persimmon fruit extract as an active ingredient. 6. A composition for deodorizing, characterized in that it is blended with an old-age odor inhibitor according to any one of claims 1 to 5. 7. The deodorant composition of claim 6 which is a skin external preparation. 8. A composition comprising oolong tea extract and sweet tea extract, further comprising green tea extract and/or red persimmon fruit extract. 9. For the composition of claim 8 of the patent scope, it is used for deodorization. 1 如 If the composition of claim 8 or 9 is a skin external preparation. -36-