JP6678411B2 - Deodorant and method for deodorizing isovaleric aldehyde - Google Patents

Description

  The present invention relates to a deodorant and a method for deodorizing isovaleric aldehyde.

Foot odor (unpleasant odor of foot) is generated when organic substances such as sebum, protein (keratin), and sweat are decomposed by bacteria that propagate in shoes. Foot odor occurs when the foot is surrounded by the inside of the footwear and sweats. Because the feet have more sweat glands than other parts of the body, they sweat excessively and the sweat produced cannot evaporate due to the foot being surrounded by footwear. Therefore, foot odor is continuously volatilized and emits an odor, and adheres to socks and shoes.
Patent Documents 1 and 2 disclose that it is believed that the main cause of foot odor is isovaleric acid, and that isovaleric acid is mainly produced by enzymatic conversion of L-leucine. ing.

Isovaleric aldehyde, a related substance of isovaleric acid, has never been reported in relation to foot odor. Odors other than foot odor are reported in Patent Documents 3 and 4 as follows.
Patent Document 3 discloses that methanethiol, propanethiol, dimethyl sulfide, dimethyl disulfide, trimethylamine, diacetyl, acetoin and 3-methylbutanal (isovaleric aldehyde) are components having a high contribution to menstrual odor or physiological odor. Is described.
Patent Literature 4 discloses that, as a result of analyzing the odor components generated by the non-aqueous skin external product contaminating microorganisms, isovaleric acid, isovaleraldehyde (isovaleraldehyde), acetoin, acetic acid, butyric acid, etc. It is stated that it had increased.
No deodorant or deodorant method for suppressing the odor of isovaleric aldehyde is described in Patent Documents 3 and 4, and has not been reported so far.

JP-A-2003-24422 Table 2009-508478 JP 2007-198829A JP 2014-150758 A

  An object of the present invention is to provide a deodorant and a deodorizing method for suppressing the odor of isovaleric aldehyde.

The present inventors have found that the intensity of foot odor strongly correlates with the amount of isovaleric aldehyde, not with the amount of isovaleric acid. In particular, with a weak foot odor, an unpleasant foot odor may be emitted even though isovaleric acid is not generated. Even in such a situation of a weak foot odor, isovaleraldehyde was generated, and it was found that even a weak foot odor could be evaluated depending on the amount of isovaleraldehyde. Based on such knowledge, the present inventors collected a sample present at the application site of the deodorant agent, measured the amount of isovaleraldehyde contained in the sample, and determined the amount of deodorant by the amount of isovaleraldehyde. The present inventors have invented a method of evaluating a deodorant agent for evaluating the performance of the agent.
The present inventors use the above-described method for evaluating a deodorant agent, etc., to suppress the odor of isovaleric aldehyde for a large number of plant extracts including a known deodorant effect and a large number of adsorption powders. As a result of the tests, it was found that the extract of asteraceae and the plant of the family Asteraceae in the plant extract, and the organic adsorption powder in the adsorption powder unexpectedly suppressed the smell of isovaleric aldehyde. The present invention is based on such knowledge, and specifically, the present invention is as follows.

[1] A deodorant for isovaleric aldehyde, comprising at least one member selected from the group consisting of an extract of an Asteraceae plant or a Camellia plant and an organic adsorption powder.
[2] The deodorant of isovaleric aldehyde according to [1], wherein the asteraceous plant is mugwort or chamomile and the camellia plant is tea tree.
[3] The deodorant of isovaleric aldehyde according to [1] or [2], wherein the organic adsorption powder is at least one selected from nylon powder.
[4] A method for deodorizing an odor containing isovaleraldehyde by applying a preparation containing at least one selected from the group consisting of an extract of an Asteraceae plant or a Camellia plant and an organic adsorption powder to the skin. .

  ADVANTAGE OF THE INVENTION By the deodorant and method of deodorizing isovaleraldehyde of this invention, the odor of isovaleraldehyde can be suppressed and odors, such as a foot odor and body odor, can be suppressed. Further, since isovaleric aldehyde is an odor that causes foot odor, the foot odor can be suppressed by the deodorant and method for deodorizing isovaleraldehyde of the present invention.

4 is a graph showing the relationship between the intensity of foot odor and the amount of isovaleric aldehyde of ten subjects in Example 1. 4 is a graph showing the relationship between the intensity of foot odor and the amount of isovaleric acid of 10 subjects in Example 1.

  As shown in Example 1, the intensity of foot odor strongly correlates with the amount of isovaleric aldehyde. Therefore, by using isovaleric aldehyde as an index, foot odor can be objectively evaluated in a wide range from a weak foot odor to a strong foot odor. Therefore, an indicator agent for determining foot odor comprising isovaleric aldehyde is useful for objective determination of foot odor, evaluation of deodorant effect or deodorant effect of foot odor, evaluation of deodorant agent, screening of foot odor inhibitor, etc. It is.

1. Evaluation method of deodorant agent The evaluation method of the deodorant agent of the present invention is to collect a sample present at the application site of the deodorant agent, measure the amount of isovaleraldehyde contained in the sample, and determine the amount of the isovaleraldehyde. It is performed by evaluating the performance of the deodorant agent by the amount.
That is, the method for evaluating a deodorant agent of the present invention uses a foot odor determination index agent of the present invention to evaluate the performance of a deodorant agent based on the amount of isovaleric aldehyde. In addition, the deodorant agent can be evaluated accurately.
In the present specification, the “deodorant agent” includes both a deodorant agent directly applied to the skin of the foot and a deodorant agent applied to socks, shoes and the like to which foot odor adheres. In addition, the application site of the deodorant agent includes, for example, skin of feet, socks, shoes, and the like.

As the application amount of the deodorant agent, it is preferable to test a plurality of adaptation amounts centered on the amount that is considered to exert the effect as the deodorant agent.
The contact time of the deodorant agent to the application site varies depending on the type of application site, the type of deodorant agent, the amount of the deodorant agent used, the amount of the active ingredient contained in the deodorant agent, for example, 1 to 72 hours, Preferably, it is 3 to 24 hours.
Collection of the sample present at the application site of the deodorant agent, for example,
(A) collecting a headspace gas at a location where the deodorant agent is applied;
(B) bringing a test piece into contact with the application location of the deodorant agent to extract a substance attached to the test piece; and (c) adding a solvent directly to the application location of the deodorant agent and adding a substance present at the application location. , Etc. can be performed.

Examples of the method for measuring the amount of isovaleraldehyde include gas chromatography-mass spectrometry, gas chromatography-flame ion detection, gas chromatography-electron capture detection, high-performance liquid chromatography-ultraviolet-visible spectroscopy, and high-speed Examples thereof include a liquid chromatography-mass spectrometry, a detection method using a semiconductor sensor, and the like, and preferably, a gas chromatography-mass spectrometry. For example, in gas chromatography-mass spectrometry, the amount of isovaleraldehyde can be calculated using the numerical value of the peak height or peak area of isovaleraldehyde in the chromatogram.
In the case of sensory evaluation of foot odor, if the average score is less than 0.5, "no foot odor"; if the average score is 0.5 or more and less than 2, "weak foot odor"; When the score is 2 or more and less than 3.5, it is possible to judge that "foot odor is moderate", and when the average score is 3.5 or more, "foot odor is strong".

  In the evaluation method of the deodorant agent of the present invention, the amount of isovaleraldehyde contained in the sample collected from the skin before the application of the deodorant agent and the isovaleraldehyde contained in the sample present at the application site of the deodorant agent , The performance of the deodorant agent can be evaluated. For example, when the amount of the foot odor determination index agent is reduced by the deodorant agent, it can be determined that the deodorant agent has a deodorizing effect of foot odor and / or a deodorant effect. Further, the performance of the deodorant can be evaluated by comparing the application site and the non-application site of the deodorant, instead of comparing before and after the application of the deodorant as described above. For example, a deodorant agent is applied to one leg and a deodorant agent is not applied to the other leg, and the amount of isovaleraldehyde contained in a sample collected from each leg is different. The performance of the agent can be evaluated.

2. Deodorant / Deodorizing Method for Isovaleraldehyde According to the present invention, a deodorant for isovaleraldehyde containing one or more selected from the group consisting of extracts of Asteraceae or Amberaceae and organic adsorption powder. Deodorization of odors containing isovaleric aldehyde by applying to the skin a preparation containing a odorant and at least one extract selected from the group consisting of an extract of asteraceae or camelliae and an organic adsorption powder. Methods and methods are provided.

In the extract of the Asteraceae plant or the Camellia plant in the present invention, examples of the Asteraceae plant include mugwort, chamomile, chrysanthemum, dandelion, sunflower, calendula, bulbul, thistle, burdock, dahlia, butterbur, thistle, and the like. Preferably, mugwort and chamomile are mentioned.
Examples of the Camellia plants include tea tree, camellia, sasanqua, and the like, and preferably, tea tree and the like.
The extracts of the Asteraceae plant and the Camellia plant are obtained by extracting the Asteraceae plant and the Camellia plant with a solvent. The sites from which the Asteraceae and Camellia plants are extracted are not particularly limited, and include, for example, leaves, flowers, fruits, seeds, bark, roots, stems, buds, and the like. Upon extraction, the plant raw material may be used as it is, or may be cut, crushed, or pulverized and provided for extraction. Further, the plant raw material may be dried before use. The extraction method is not particularly limited as long as each component can be extracted, and can be appropriately selected from known methods. For example, it can be carried out by immersing a plant material in an extraction solvent and, if necessary, heating and / or pressurizing. The extraction temperature and the extraction time can be appropriately changed according to the type of the extraction solvent, the type of the plant, the use of the extract, and the like.

The mugwort extract is not particularly limited as long as it is a mugwort extract, and examples thereof include those extracted from mugwort stems and / or leaves, and preferably those extracted from mugwort leaves. A mugwort extract as a raw material or a quasi-drug raw material can also be used.
The chamomile extract is not particularly limited as long as it is a chamomile extract, and examples thereof include those extracted from chamomile flowers. Chamomile extract, which is a cosmetic raw material or a quasi-drug raw material, can also be used.
The tea tree extract is not particularly limited as long as it is a tea tree extract, and examples thereof include those extracted from tea tree leaves. Green tea extract, which is a cosmetic raw material or a quasi-drug raw material, can also be used.

  As the extraction solvent, any of water and an organic solvent can be used. Examples of the organic solvent include methanol, ethanol, propanol, isopropyl alcohol, butanol, lower alcohols such as isobutanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyhydric alcohols such as glycerin, diethyl ether, Ethers such as dipropyl ether; esters such as ethyl acetate and butyl acetate; ketones such as acetone and ethyl methyl ketone. One extraction solvent may be used alone, or two or more extraction solvents may be used in combination. Among them, water, lower alcohol and polyhydric alcohol are preferable, and water, ethanol, propylene glycol and butylene glycol are more preferable. When two or more kinds are used in combination, it is preferable to use a mixture of ethanol and water or a mixture of butylene glycol and water. In that case, the usage ratio of ethanol is preferably about 30 to 90% by volume, more preferably about 40 to 80% by volume, based on the whole solvent.

As the extraction solvent, a solvent at room temperature or normal temperature can be used, but a heated solvent or a hot solvent (a solvent obtained by heating the solvent to near the boiling point) can also be used. Specifically, when the extraction solvent is water, the temperature at the time of extraction is not particularly limited as long as it is equal to or lower than the boiling point of the solvent, but is preferably about 40 to 100 ° C, more preferably about 60 to 100 ° C, and about 80 to 100 ° C. -100 ° C is even more preferred. Within the above range, components having antiglycation activity can be sufficiently extracted. Although the extraction time is not particularly limited, it can be generally about 30 seconds to 4 hours, preferably about 3 to 50 minutes, more preferably about 4 to 40 minutes.
Further, if necessary, the mixture can be stirred and extracted at normal pressure. However, the extraction method and the extraction conditions are not particularly limited. For example, pressure extraction can be performed.
The deodorant of isovaleric aldehyde of the present invention may be a preparation comprising an extract in a dry state or a preparation of a liquid in which the extract in a dry state is mixed with a solvent. Examples of the solvent include the solvents mentioned as the extraction solvent.

In the organic adsorption powder of the present invention, any one can be used as long as it can adsorb isovaleric aldehyde. Examples of the organic adsorption powder include nylon powder, silicone resin, polyethylene powder, cross-linked polystyrene, methylsiloxane network polymer, (vinyl dimethicone / methicone silsesquioxane) crosspolymer, and (diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioki). Sun) Crosspolymer, Polysilicone-1 Crosspolymer, Polysilicone-22, Polymethylsilsesquioxane (methylsiloxane network polymer), (Dimethicone / Vinyldimethicone) Crosspolymer, Acrylate Crosspolymer, High Melting Polyethylene Powder, Nylon -12, nylon-6 / 12 and the like, and from the viewpoint of exerting the effects of the invention, nylon powder and silicone resin are preferable.
These powders may use commercially available products, for example, KSP-100, KSP-101, KSP-300, KSP-105, KSP-411, KSP-441, KMP-590, KMP-591, Tospearl 1110A (Registered trademark), Tospearl 150KA (registered trademark), Tospearl 2000B (registered trademark), Ganz Pearl SI-020 (registered trademark), Ganz Pearl GMP-0820 (registered trademark), Ganz Pearl GS-1105 (registered trademark), Ganz Pearl GS-2006 (registered trademark), Miperon PM-200 (registered trademark), ORGASOL 2002 UD NAT COS (registered trademark), ORGASOL 2002 EXD NAT COS (registered trademark), ORGASOL 2002 EXD NAT COS TypeS (registered trademark), ORGASOL Commercial products such as 4000 EXD NAT COS (registered trademark), nylon powder SP-10, and nylon powder SP-500 can be used.
By combining the plant extract and the organic adsorption powder, the odor of isovaleric aldehyde can be further suppressed additively or synergistically.

The isovaleraldehyde deodorant of the present invention can suppress the odor of isovaleraldehyde present on the skin such as feet, and therefore can be used for cosmetics and pharmaceuticals for suppressing the odor of isovaleraldehyde. It can be suitably used for foreign products, pharmaceuticals and the like.
The deodorant of isovaleric aldehyde of the present invention can be formulated as, for example, cosmetics, quasi-drugs, pharmaceuticals and the like. As the dosage form of the preparation, for example, lotion, mist, milky lotion, gel, cream, serum, body lotion, body cream, aerosol, roll-on, stick, detergent, cream, sheet and other basic cosmetics, and Detergents (eg, deodorant cream, deodorant lotion, deodorant mist, deodorant gel, deodorant spray, deodorant roll-on, deodorant paper, etc.) , Deodorant sticks, etc.), detergents (facial cleansers, body shampoos, shampoos, rinses, etc.), emulsions, skin care creams, sheet cosmetics (eg, wiping sheets, sheet packs, etc.).

The content of the deodorant of isovaleraldehyde of the present invention can be appropriately adjusted according to the type of plant extract, the type of organic adsorption powder, the use of the deodorant of isovaleraldehyde, and the like. . When a plant extract is used, the content of the plant extract in a dry state in the above preparation is, for example, 0.000001 to 1% by weight, preferably 0.00001 to 0.5% by weight. And more preferably 0.0001 to 0.1% by weight. When an organic adsorption powder is used, the content of the organic adsorption powder in the preparation is, for example, 0.01 to 50% by weight, preferably 0.05 to 30% by weight, more preferably 0 to 30% by weight. 0.1 to 20% by weight.
Cosmetics, quasi-drugs, pharmaceuticals and the like containing the deodorant of isovaleric aldehyde of the present invention include cosmetics, quasi-drugs, raw materials usually used in pharmaceuticals, such as oils, surfactants, Components such as alcohols, preservatives, chelating agents, antioxidants, thickeners, fragrances, and bactericides can be added to the cosmetics, quasi-drugs, pharmaceuticals, and the like for use.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples, but the present invention is not limited thereto.
The evaluation of the intensity of foot odor, the sampling from the foot, and the analysis of the amounts of isovaleric acid and isovaleric aldehyde were performed as follows.

Evaluation method of foot odor intensity Three panelists evaluated the foot odor intensity on the soles and fingers (socks and test pieces) using the following evaluation criteria. An average value was calculated from the numerical values of the obtained evaluation results, and the result was taken as the intensity of foot odor.
〔Evaluation criteria〕
0: No smell 1 point: Slightly smell 2 points: Slightly smell 3 points: Clearly smell 4 points: Slightly strong 5 points: Significantly smell

Method of Sampling from Feet Subjects wear specified socks (washed, 100% cotton) and shoes and leave them for a certain period of time (6 hours). After standing, a 2 cm x 8 cm test piece (100% cotton) was folded in two between the thumb and forefinger, between the forefinger and middle finger, and between the middle and ring fingers, and then the tape was applied so that it did not come off. Wrap, socks and shoes. After a lapse of 2 hours, the socks and the test piece are collected and subjected to sensory evaluation (smell).

Method for analyzing the amount of isovaleric acid and isovaleric aldehyde A sample (test piece) obtained from a foot was inserted into a headspace vial, and the vaporized component was subjected to headspace-gas chromatography-mass spectrometry (HSS-GC- The peak height (or peak area) of isovaleric acid and isovaleric aldehyde was obtained by analysis using MS) under the following conditions.
[GC-MS analysis conditions]
Model: Headspace-gas chromatograph-mass spectrometer (HSS-GC-MS) manufactured by Agilent Technologies
HSS: 7697A
GC: 7890B
MS: 5977A
Column: GL Science InertCap Pure Wax 60m, 0.25mm I. D. , 0.25 μm
Carrier gas: He

[Test conditions]
<Head space condition>
Loop size: 3mL
Oven temperature: 45 ° C
Loop temperature: 75 ° C
Transfer line temperature: 100 ° C
Vial equilibration: 10 minutes Injection time: 1 minute However, Example 3 was performed by changing the oven temperature to 70 ° C. under the headspace condition.
<GC conditions>
Temperature: 40 ° C (2 minutes) ⇒ Heating (3 ° C / min) ⇒ 180 ° C ⇒ Heating (10 ° C / min) ⇒ 220 ° C
Inlet: 200 ° C
Split ratio 10: 1
Average linear velocity: 28 cm / sec. However, in Examples 3 and 4, the temperature and the split ratio were changed under the GC conditions as follows.
Temperature: 40 ° C (8 minutes) ⇒ Heating (3 ° C / min) ⇒ 180 ° C ⇒ Heating (10 ° C / min) ⇒ 220 ° C
Split ratio 20: 1
<MS condition>
Ionization method: Electron ionization method (EI)

[Quantitative determination of isovaleric aldehyde]
Based on the peak height (or peak area) of isovaleraldehyde obtained from the above analysis results, the quantitative value (ppm) of isovaleraldehyde was determined as described below.
A propylene glycol solution of isovaleraldehyde with a known concentration was prepared and added to a headspace vial as a standard sample. The sample and the standard sample were tested by HSS-GC-MS under the above conditions, and the peak height (or peak area) of the sample and the standard sample was determined.
Amount of isovaleric aldehyde (ppm)
= Concentration (ppm) of standard sample x peak height (or peak area) of sample / peak height (or peak area) of standard sample
In Example 1, evaluation was made based on the peak heights of isovaleric acid and isovaleric aldehyde. In Examples 2 to 4, quantitative values were determined based on the peak area of isovaleric aldehyde.

Example 1
Relationship between the intensity of foot odor and the amounts of isovaleric aldehyde and isovaleric acid According to the evaluation method of the intensity of foot odor, the sampling from the feet, and the method of analyzing the amounts of isovaleric acid and isovaleric aldehyde, subjects 10 The foot odor of the name was evaluated and analyzed. The results of the evaluation and analysis are summarized in FIGS. In FIG. 1, ten subjects are arranged on the horizontal axis, the “foot odor intensity” of each subject is plotted with ● on the vertical axis, and “the peak height of isovaleraldehyde” of each subject is plotted with Δ. ing. In FIG. 2, ten subjects are arranged on the horizontal axis, the "foot odor intensity" of each subject is plotted with ● on the vertical axis, and the "peak height of isovaleric acid" of each subject is plotted with ■. I have.
As can be seen from FIG. 2, isovaleric acid is not observed particularly in a place where the intensity of foot odor is low, and cannot be an index indicating the intensity of foot odor. On the other hand, as can be seen from FIG. 1, the amount of isovaleric aldehyde has a strong correlation with the intensity of foot odor in a wide range from a low intensity to a high intensity.
From the above, it can be seen that isovaleric aldehyde can be used as an excellent index for determining foot odor indicating the strength of foot odor.

Example 2
Evaluation of Deodorant The deodorant (medicated mentholatum refrea toe cream: Rohto Pharmaceutical Co., Ltd.) was applied to the feet of the test subjects. Thereafter, the designated socks (washed, 100% cotton) and shoes were put on, and left for a fixed time (6 hours). After standing, a 2 cm x 8 cm test piece (100% cotton) was folded in two between the thumb and forefinger, between the forefinger and middle finger, and between the middle and ring fingers, and then the tape was applied so that it did not come off. Wore, socks and shoes. After a further 2 hours, the socks and test pieces were collected, and the collected test pieces were inserted into a headspace analysis vial, and the amount (A) of isovaleraldehyde attached to the test pieces was analyzed.
In addition, the same operation as described above was performed without applying the deodorant agent to the test subject's feet, and the amount (B) of isovaleraldehyde attached to the test piece worn by the test subject was analyzed.
The amount of isovaleraldehyde (A) was compared with the amount of isovaleraldehyde (B) to determine whether the deodorant agent reduced the foot odor indicator. When the index agent for determining foot odor was reduced by the deodorant agent, the deodorant agent was evaluated as having a deodorizing effect and / or an anti-odor effect. Table 1 shows the results.

In Subject No. 1, the right foot to which deodorant was applied had a foot odor intensity of 1, while the left foot to which no deodorant was applied had a high foot odor intensity of 3 and generation of isovaleraldehyde. The amount was 4.0 times higher than the right foot. The same result was obtained for the subject No. 2, and the generation amount of isovaleric aldehyde was different by 2.8 times.
From the above test results, it can be seen that the effect of the deodorant agent can be confirmed by using the amount of isovaleric aldehyde as an index.

Example 3
Test of reduction rate of isovaleraldehyde by plant extract The reduction rate of isovaleraldehyde was tested using the extracts obtained from the plants described in Table 2.
0.5 mL of a 2 ppm isovaleraldehyde / polyethylene glycol solution and 1 mL of the plant extract described in Table 2 are added to a 20 mL headspace GC vial, and MonoTrap (DCC-18) manufactured by GL Sciences is suspended in the vial. The gas inside was collected. The MonoTrap was taken out, placed in a 20-mL headspace vial, added with 0.5 mL of polyethylene glycol, sealed, and subjected to ultrasonic treatment for 10 minutes to obtain a sample. Separately, 0.5 mL of a 2 ppm solution of isovaleraldehyde in polyethylene glycol was operated in the same manner as the sample, and the standard sample was used as the standard sample. The peak area of the isovaleraldehyde was measured for the sample and the standard sample using a headspace gas chromatograph mass spectrometer. did. From the peak area of isovaleraldehyde in the standard sample with respect to the sample, the reduction rate of isovaleraldehyde in each sample was calculated. Table 2 shows the results.

a1) Mugwort liquid (Ichimaru Falcos)
a2) Chamois liquid (Ichimaru Falcos)
a3) Green tea liquid (Ichimaru Falcos)
a4) Falco Rex Peppermint B (Ichimaru Falcos)
a5) Falco Rex Yarrow B (Ichimaru Falcos)
a6) Falco Rex Honeysuckle SB (Ichimaru Falcos)
a7) Falco Rex Rosemary B (Ichimaru Falcos)
a8) Falco Rex Sage B (Ichimaru Falcos)
a9) Salvia extract BG-J (Maruzen Pharmaceutical)
a10) Falco Rex Enmeiso B (Ichimaru Falcos)
a11) Falco Rex BX46 (Ichimaru Falcos)
a12) Falco Rex Eucalyptus B (Ichimaru Falcos)
a13) Marjoram extract BG (Maruzen Pharmaceutical)
a14) Falco Rex Novara B (Ichimaru Falcos)
a15) Oubak extract BG-J (Maruzen Pharmaceutical)
a16) Sweet tea extract BGW (Maruzen Pharmaceutical)
a17) Hypericum extract BG (Maruzen Pharmaceutical)
a18) Hamamelis extract BG-J (Maruzen Pharmaceutical)
a19) Sakura extract B (Ichimaru Falcos)

  A number of plant extracts, including those with known deodorant effects, were tested to reduce the odor of isovaleric aldehyde, but most plant extracts did not suppress odor, as described above. Was. However, surprisingly, only extracts of chamomile, mugwort and green tea significantly suppressed the odor of isovaleric aldehyde.

Example 4
Test of Reduction Rate of Isovaleraldehyde by Adsorption Powder The reduction rate of isovaleraldehyde was tested using the adsorption powders described in Table 3.
0.25 mL of a 2 ppm isovaleraldehyde / polyethylene glycol solution and 0.2 g of the adsorption powder shown in Table 3 were added to a 20 mL headspace GC vial, and the sample was sealed. Separately, a standard sample was prepared by adding 1 mL of polyethylene glycol to 0.25 mL of a polyethylene glycol solution of 2 ppm isovaleraldehyde and measuring the peak area of isovaleraldehyde with a headspace gas chromatograph mass spectrometer for the sample and the standard sample. did. From the peak area of isovaleraldehyde in the standard sample with respect to the sample, the reduction rate of isovaleraldehyde in each sample was calculated. Table 3 shows the results.

b1) ORGASOL 2002 EXD NAT COS (registered trademark) (Arkema Corporation)
b2) ORGASOL 2002 EXD NAT COS Type S (registered trademark) (Arkema Corporation)
b3) ORGASOL 4000 EXD NAT COS (registered trademark) (Arkema Corporation)
b4) Tospearl 2000B (registered trademark) (Momentive Performance Materials Japan GK)
b5) KMP-590 (Shin-Etsu Chemical Co., Ltd.)
b6) KSP-300 (Shin-Etsu Chemical Co., Ltd.)
b7) Matsumoto Microsphere M-305 QD7 (registered trademark) (Matsumoto Yushi Pharmaceutical Co., Ltd.)
b8) Matsumoto Microsphere M-305 QD7N (registered trademark) (Matsumoto Yushi Pharmaceutical Co., Ltd.)
b9) Ganz Pearl SI-020 (registered trademark) (Aika Industry Co., Ltd.)
b10) Gantz Pearl GMP-0820 (registered trademark) (Aika Industry Co., Ltd.)
b11) Gantz Pearl GS-1105 (registered trademark) (Aika Industry Co., Ltd.)
b12) Sunsphere H-51 (registered trademark) (AGC S-Tech Co., Ltd.)
b13) Sunsphere H-121 (registered trademark) (AGC S-Tech Co., Ltd.)
b14) Godball N-15C (registered trademark) (AGC S-I-Tech Co., Ltd.)

From this test result, it can be seen that silicic anhydride, which is an inorganic adsorbing powder, does not adsorb isovaleric aldehyde at all, whereas organic adsorbing powder adsorbs isovaleric aldehyde, and the odor is reduced. Among organic adsorption powders, in particular, nylon powder (nylon-12, nylon-6 / 12), ORGASOL 2002 EXD NAT COS, ORGASOL 2002 EXD NAT COS TypeS and ORGASOL 4000 EXD NAT COS (registered trademark: Arkema Corporation) are 50. %, Which indicates a remarkably powerful deodorizing effect on isovaleric aldehyde.
By combining the plant extract with the adsorption powder, the odor of isovaleric aldehyde can be further suppressed.

  The embodiment disclosed this time is an example in all respects and should be considered as not being restrictive. The scope of the present invention is defined by the terms of the claims, rather than the description above, and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims.

  ADVANTAGE OF THE INVENTION By the deodorant and the deodorizing method of this invention, the odor of isovaleric aldehyde can be suppressed and odors, such as foot odor and body odor, can be suppressed. Further, since isovaleric aldehyde is an odor that causes foot odor, the foot odor can be suppressed by the deodorant and method for deodorizing isovaleraldehyde of the present invention.

Claims (5)

A deodorant for isovaleric aldehyde, comprising one or more selected from the group consisting of extracts of asteraceae plants and organic adsorption powder,
The Asteraceae plant is a mugwort or chamomile,
The organic adsorption powder, nylon powder is silicone resin, one or more selected from the group consisting of cross-linking polystyrene and acrylate crosspolymer,
Deodorant for isovaleric aldehyde.   The deodorant according to claim 1, wherein the organic adsorption powder is nylon powder.   The deodorant according to claim 1, wherein the organic adsorption powder is nylon 12. A method for deodorizing an odor containing isovaleraldehyde by applying a preparation containing at least one selected from the group consisting of an extract of an Asteraceae plant and an organic adsorption powder to the skin,
The Asteraceae plant is a mugwort or chamomile,
The organic adsorption powder, nylon powder is silicone resin, one or more selected from the group consisting of cross-linking polystyrene and acrylate crosspolymer,
A method for deodorizing odors containing isovaleric aldehyde. A method for deodorizing an odor containing isovaleric aldehyde, using at least one selected from the group consisting of an extract of an Asteraceae plant and an organic adsorption powder,
The Asteraceae plant is a mugwort or chamomile,
The organic adsorption powder, nylon powder is silicone resin, one or more selected from the group consisting of cross-linking polystyrene and acrylate crosspolymer,
A method for deodorizing odors containing isovaleric aldehyde.