JP2017043567A - Deodorizer and deodorizing method for isovaleric aldehyde - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide deodorizers and deodorizing methods of suppressing the odor for isovaleric aldehyde.SOLUTION: A deodorizer for isovaleric aldehyde contains one or more selected from the group consisting of extract of Asteraceae plant or Theaceae plant and organic adsorptive powders. A deodorizing method of odor containing isovaleric aldehyde includes a step of applying to the skin a formulation containing one or more selected from the group consisting of extract of Asteraceae plant or Theaceae plant and organic adsorptive powders.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a deodorant and a method for deodorizing isovaleric aldehyde.

Foot odor (unpleasant odor of the foot) is generated by decomposition of organic substances such as sebum, protein (keratin), and sweat by bacteria that propagate in shoes. Foot odor occurs when the foot is surrounded by the footwear and sweats. Since the foot has more sweat glands than the rest of the body, it sweats excessively and the sweat produced cannot evaporate due to the foot being surrounded by the footwear. Therefore, foot odors continuously evaporate and give off odors, which also adhere to socks and shoes.
Patent Documents 1 and 2 describe that the main causative substance of the foot odor is considered to be isovaleric acid, and that isovaleric acid is mainly produced by enzymatic conversion of L-leucine. ing.

For isovaleric aldehyde, which is a related substance of isovaleric acid, no reports related to foot odor have ever been made. Odors other than foot odor are reported in Patent Documents 3 and 4 as follows.
In Patent Document 3, methanethiol, propanethiol, dimethylsulfide, dimethyldisulfide, trimethylamine, diacetyl, acetoin, and 3-methylbutanal (isovaleric aldehyde) are components having a high contribution to menstrual odor or physiological odor. It is described that it is.
In Patent Document 4, as a result of analyzing components of odor generated when a nonaqueous skin external product is contaminated with microorganisms, isovaleric acid, isovaleraldehyde (isovaleric aldehyde), acetoin, acetic acid, butyric acid, etc. are greatly increased. It is described that it had increased.
No deodorant or deodorizing method for suppressing the odor of isovaleric aldehyde is described in Patent Documents 3 and 4, and has not been reported so far.

JP2003-24422 Special table 2009-508478 JP2007-198829 JP 2014-150758 A

  The subject of this invention is providing the deodorizing agent and the deodorizing method which suppress the smell of isovaleric acid aldehyde.

The present inventors have found that the intensity of foot odor strongly correlates with the amount of isovaleric aldehyde, not the amount of isovaleric acid. In particular, a weak foot odor may give off an unpleasant foot odor despite the absence of isovaleric acid. It was found that even in such a weak foot odor situation, isovaleric aldehyde was generated, and even a weak foot odor could be evaluated by the amount of isovaleric aldehyde. Based on this knowledge, the present inventors collected a sample present at the application site of the deodorant agent, measured the amount of isovaleric aldehyde contained in the sample, and deodorant according to the amount of isovaleric aldehyde. Invented a deodorant evaluation method for evaluating the performance of the agent.
Whether the present inventors use the above-described deodorant evaluation method or the like to suppress the odor of isovaleric aldehyde for many plant extracts and many adsorbent powders, including those with known deodorant effects. As a result of the above test, it was found that the extract of Asteraceae and Camelliaaceae plants was extracted as a plant extract, and the organic adsorbent powder was suppressed as an adsorbent powder, which surprisingly suppressed the smell of isovaleric aldehyde. The present invention is based on such knowledge. Specifically, the present invention is as follows.

[1] An isovaleric aldehyde deodorant containing at least one selected from the group consisting of an extract of an Asteraceae plant or a camellia plant and an organic adsorption powder.
[2] The deodorizer for isovaleric aldehyde according to [1], wherein the Asteraceae plant is Artemisia or Chamomile, and the Camellia family plant is Chanoki.
[3] The deodorizer for isovaleric aldehyde according to [1] or [2], wherein the organic adsorption powder is at least one selected from nylon powder.
[4] A method for deodorizing odors containing isovaleric aldehyde by applying to the skin a preparation containing at least one selected from the group consisting of an extract of an Asteraceae plant or a camellia plant and an organic adsorption powder .

  By the deodorizing agent and deodorizing method of isovaleric aldehyde of the present invention, the odor of isovaleric aldehyde can be suppressed and odors such as foot odor and body odor can be suppressed. Further, since isovaleric aldehyde is a causative odor of foot odor, the foot odor can be suppressed by the deodorant and method of isovaleric aldehyde of the present invention.

6 is a graph showing the relationship between the intensity of foot odor of 10 subjects and the amount of isovaleric aldehyde in Example 1. FIG. 4 is a graph showing the relationship between the intensity of foot odor and the amount of isovaleric acid of 10 subjects in Example 1.

  As shown in Example 1, the intensity of foot odor strongly correlates with the amount of isovaleric aldehyde. Therefore, by using isovaleric aldehyde as an index, foot odor can be objectively evaluated in a wide range from weak foot odor to strong foot odor. Therefore, an indicator for foot odor judgment made of isovaleric aldehyde is useful for objective judgment of foot odor, evaluation of deodorizing effect or deodorizing effect of foot odor, evaluation of deodorant agent, screening of foot odor inhibitor, etc. It is.

1. Method for evaluating deodorant agent The method for evaluating the deodorant agent of the present invention is to collect a sample present at the application site of the deodorant agent, measure the amount of isovaleric aldehyde contained in the sample, and determine the amount of isovaleric aldehyde. It is carried out by evaluating the performance of the deodorant agent by the amount.
That is, since the deodorant agent evaluation method of the present invention evaluates the performance of the deodorant agent based on the amount of isovaleric acid aldehyde using the foot odor determination indicator of the present invention, it is objective and simple. A deodorant agent can be evaluated accurately and accurately.
In the present specification, the “deodorant agent” includes both a deodorant agent applied directly to the skin of a foot and a deodorant agent applied to an object to which foot odors such as socks and shoes adhere. In addition, examples of the application site of the deodorant agent include foot skin, socks, and shoes.

As the application amount of the deodorant agent, it is preferable to test a plurality of adaptation amounts centering on an amount that will be effective as a deodorant agent.
The contact time of the deodorant agent to the application site varies depending on the type of application site, the type of deodorant agent, the amount of deodorant agent used, the amount of active ingredient contained in the deodorant agent, etc., for example, 1 to 72 hours, more Preferably 3-24 hours etc. are mentioned.
Collection of the sample present at the application site of the deodorant agent is, for example,
(A) collecting the headspace gas at the application site of the deodorant;
(B) bringing a test piece into contact with the application site of the deodorant agent and extracting a substance adhering to the test piece; and (c) adding a solvent directly to the application site of the deodorant agent and presenting the substance at the application site. This can be done by extracting, for example.

Examples of the method for measuring the amount of isovaleric aldehyde include gas chromatography-mass spectrometry, gas chromatograph-hydrogen flame ion detection method, gas chromatograph-electron capture detection method, high-speed liquid chromatograph-ultraviolet visible spectroscopy, high-speed spectroscopy. Examples of the method include a liquid chromatograph-mass spectrometry method, a detection method using a semiconductor sensor, and a gas chromatograph-mass spectrometry method is preferable. For example, in the gas chromatograph-mass spectrometry, the amount of isovaleric aldehyde can be calculated using the peak height or peak area value of isovaleric aldehyde in the chromatogram.
In the case of sensory evaluation of foot odor, “no foot odor” when the average score is less than 0.5, “weak foot odor” when the average score is 0.5 to less than 2, the average score In the case of 2 or more and less than 3.5, it can be judged that “foot odor is moderate”, and in the case of an average score of 3.5 or more, “foot odor is strong”.

  In the deodorant evaluation method of the present invention, the amount of isovaleric aldehyde contained in the sample collected from the skin before application of the deodorant and the isovaleric aldehyde contained in the sample present at the application site of the deodorant. The performance of the deodorant agent can be evaluated based on a difference from the amount of the deodorant. For example, when the amount of the indicator for determining foot odor is reduced by the deodorant agent, it can be determined that the deodorant agent has a deodorizing effect and / or a deodorizing effect on the foot odor. Moreover, the performance of a deodorant agent can be evaluated by comparing the application site | part of a deodorand agent, and a non-application site | part instead of the comparison before and behind application of a deodorant agent as mentioned above. For example, if a deodorant is applied to one foot and a deodorant agent is not applied to the other foot, the deodorant may vary depending on the amount of isovaleric aldehyde contained in the sample collected from each foot. The performance of the agent can be evaluated.

2. Deodorant / Method for Deodorizing Isovaleric Aldehyde According to the present invention, the elimination of isovaleric aldehyde comprising at least one selected from the group consisting of an extract of an Asteraceae plant or a camellia plant and an organic adsorption powder. Deodorizing odors containing isovaleric aldehyde by applying to the skin a odorant and a preparation containing at least one selected from the group consisting of an extract of an Asteraceae plant or a camellia plant and an organic adsorption powder A method is provided.

In the extract of the Asteraceae plant or the camellia plant in the present invention, examples of the Asteraceae plant include mugwort, chamomile, chrysanthemum, dandelion, sunflower, calendula, chickweed, thistle, burdock, dahlia, fuchsia, thistle, etc. Preferred examples include mugwort and chamomile.
Examples of camellia plants include chanoki, camellia, sasanqua and the like, and preferably cypress.
The extracts of Asteraceae and Camelliaaceae plants are extracts of Asteraceae and Camelliaaceae plants extracted with a solvent. The extraction site of the Asteraceae and Camellia plants is not particularly limited, and examples thereof include leaves, flowers, fruits, seeds, bark, roots, stems, and buds. In the extraction, the plant raw material may be used as it is, or may be cut, crushed, or pulverized and used for the extraction. Moreover, you may dry and use a plant raw material. The extraction method is not particularly limited as long as each component can be extracted, and a known method can be selected as appropriate. For example, it can be carried out by immersing a plant material in an extraction solvent and, if necessary, heating and / or pressurizing. Moreover, extraction temperature and extraction time can be suitably changed according to the kind of extraction solvent, the kind of plant, the use of an extract, etc.

The mugwort extract is not particularly limited as long as it is a mugwort extract, and examples include mugwort extracts extracted from mugwort stems and / or leaves, preferably those extracted from mugwort leaves, and cosmetics. Artemisia extract as a raw material or quasi-drug material can also be used.
The chamomile extract is not particularly limited as long as it is an extract of chamomile. Examples include chamomile extract extracted from chamomile flowers, and chamomile extract of cosmetic raw materials or quasi-drugs can also be used.
The chanoki extract is not particularly limited as long as it is a chanoki extract, but examples thereof include those extracted from chanoki leaves, and a green tea extract as a cosmetic raw material or a quasi-drug raw material can also be used.

  As the extraction solvent, either water or an organic solvent can be used. Examples of the organic solvent include lower alcohols such as methanol, ethanol, propanol, isopropyl alcohol, butanol and isobutanol, polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol and glycerin, diethyl ether, Examples thereof include ethers such as dipropyl ether, esters such as ethyl acetate and butyl acetate, and ketones such as acetone and ethyl methyl ketone. An extraction solvent can be used individually by 1 type or in combination of 2 or more types. Among these, water, lower alcohol, and polyhydric alcohol are preferable, and water, ethanol, propylene glycol, and butylene glycol are more preferable. When using 2 or more types in combination, it is preferable to use a mixture of ethanol and water or a mixture of butylene glycol and water. In this case, the use ratio of ethanol is preferably about 30 to 90% by volume, and more preferably about 40 to 80% by volume with respect to the whole solvent.

As the extraction solvent, a solvent at room temperature or room temperature can be used, but a heating solvent or a heating solvent (a solvent heated near the boiling point) can also be used. Specifically, when the extraction solvent is water, the temperature at the time of extraction is not particularly limited as long as it is equal to or lower than the boiling point of the solvent, but is preferably about 40 to 100 ° C, more preferably about 60 to 100 ° C, and about 80 Even more preferred is ~ 100 ° C. If it is the said range, the component which has anti- glycation activity can fully be extracted. The extraction time is not particularly limited, but can be generally about 30 seconds to 4 hours, preferably about 3 to 50 minutes, and more preferably about 4 to 40 minutes.
Moreover, it can stir as needed and can extract at a normal pressure. However, the extraction method and extraction conditions are not particularly limited, and for example, pressure extraction can be performed.
The isovaleric aldehyde deodorant of the present invention may be a preparation comprising a dry extract or a liquid preparation prepared by mixing the dry extract with a solvent. Examples of the solvent include the solvents mentioned as the extraction solvent.

Any organic adsorbent powder of the present invention can be used as long as it can adsorb isovaleric aldehyde. Examples of the organic adsorption powder include nylon powder, silicone resin, polyethylene powder, cross-linked polystyrene, methylsiloxane network polymer, (vinyl dimethicone / methicone silsesquioxane) crosspolymer, (diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane). Sun) Crosspolymer, Polysilicone-1 Crosspolymer, Polysilicone-22, Polymethylsilsesquioxane (methylsiloxane network polymer), (Dimethicone / Vinyldimethicone) crosspolymer, Acrylate crosspolymer, High melting point polyethylene powder, Nylon -12, nylon-6 / 12, and the like. From the viewpoint of exhibiting the effects of the invention, nylon powder and silicone resin are preferable.
These powders may be commercially available, for example, KSP-100, KSP-101, KSP-300, KSP-105, KSP-411, KSP-441, KMP-590, KMP-591, Tospearl 1110A (Registered trademark), Tospearl 150KA (registered trademark), Tospearl 2000B (registered trademark), Gantz Pearl SI-020 (registered trademark), Gantz Pearl GMP-0820 (registered trademark), Gantz Pearl GS-1105 (registered trademark), Gantz Pearl GS-2006 (registered trademark), Mipperon PM-200 (registered trademark), ORGASOL 2002 UD NAT COS (registered trademark), ORGASOL 2002 EXD NAT COS (registered trademark), ORGASOL 2002 EXD NAT COS TypeS (registered trademark), ORGASOL Commercial products such as 4000 EXD NAT COS (registered trademark), nylon powder SP-10, and nylon powder SP-500 can be used.
By combining the plant extract and the organic adsorption powder, the smell of isovaleric aldehyde can be further suppressed additively or synergistically.

Since the deodorizer for isovaleric aldehyde of the present invention can suppress the smell of isovaleric aldehyde present on the skin such as feet, cosmetics and pharmaceutical parts for suppressing the smell of isovaleric aldehyde It can be suitably used for external products, pharmaceuticals and the like.
The isovaleric aldehyde deodorant of the present invention can be formulated as, for example, cosmetics, quasi drugs, pharmaceuticals, and the like. Examples of the dosage form of the preparation include basic cosmetics such as lotion, mist, emulsion, gel, cream, serum, body lotion, body cream, aerosol, roll-on, stick, cleaning agent, cream, sheet, and the like. Cosmetics for cleaning such as facial cleansers, body shampoos, shampoos, rinses, etc., specifically, deodorant agents (for example, deodorant cream, deodorant lotion, deodorant mist, deodorant gel, deodorant spray, deodorant roll-on, deodorant paper) , Deodorant sticks, etc.), detergents (face wash, body shampoo, shampoo, rinse, etc.), emulsions, skin care creams, sheet cosmetics (for example, wiping sheets, sheet pack agents, etc.).

The content of the deodorant of isovaleric aldehyde of the present invention can be appropriately adjusted according to the type of plant extract, the type of organic adsorption powder, the use of the deodorant of isovaleric aldehyde, etc. . In the case of using a plant extract, the content of the dried plant extract in the above preparation is, for example, 0.000001 to 1% by weight, preferably 0.00001 to 0.5% by weight. More preferably, 0.0001 to 0.1 weight% is mentioned. When using organic adsorption powder, as content of organic adsorption powder in the said formulation, 0.01-50 weight% is mentioned, for example, Preferably 0.05-30 weight% is mentioned, More preferably, it is 0. 0.1 to 20% by weight.
Cosmetics, quasi-drugs, pharmaceuticals, etc. containing the deodorant of isovaleric aldehyde of the present invention, cosmetics, quasi-drugs, raw materials usually used for pharmaceuticals, such as oils, surfactants, Components such as alcohol, preservatives, chelating agents, antioxidants, thickeners, fragrances, and bactericides can be added to the cosmetics, quasi drugs, pharmaceuticals, and the like.

EXAMPLES Hereinafter, although an Example and a test example demonstrate this invention further in detail, this invention is not limited to these at all.
Evaluation of foot odor intensity, sampling from the foot, and analysis of the amount of isovaleric acid and isovaleric aldehyde were performed as follows.

Evaluation method of foot odor intensity Three panelists evaluated the foot odor intensity on the soles and fingers (socks and test pieces) of the foot using the following evaluation criteria. An average value was calculated from the numerical values of the obtained evaluation results, and was used as the intensity of foot odor.
〔Evaluation criteria〕
0 point: not smelling 1 point: faintly smelling 2 points: weakly smelling 3 points: clearly smelling 4 points: smelling slightly strong 5 points: smelling very strongly

Sampling method from the foot The subject wears the specified socks (washed, 100% cotton) and shoes, and is left for a certain time (6 hours). After leaving, fold a 2cm x 8cm test piece (100% cotton) between the thumb and forefinger, between the forefinger and middle finger, and between the middle and ring fingers, and then place the tape so that it does not come off. Wear rolls, socks and shoes. Further, after 2 hours, socks and test pieces are collected and subjected to sensory evaluation (olfaction).

Method for Analyzing Amount of Isovaleric Acid and Isovaleric Aldehyde A sample (test piece) obtained from the foot was inserted into a headspace vial, and the vaporized components were subjected to headspace-gas chromatography-mass spectrometry (HSS-GC- MS) was used under the following conditions to obtain the peak height (or peak area) of isovaleric acid and isovaleric aldehyde.
[GC-MS analysis conditions]
Model: Headspace-gas chromatograph-mass spectrometer (HSS-GC-MS) manufactured by Agilent Technologies
HSS: 7697A
GC: 7890B
MS: 5977A
Column: GL Science InertCap Pure Wax 60m, 0.25mmI. D. , 0.25 μm
Carrier gas: He

[Test conditions]
<Head space conditions>
Loop size: 3mL
Oven temperature: 45 ° C
Loop temperature: 75 ° C
Transfer line temperature: 100 ° C
Vial equilibration: 10 minutes Injection time: 1 minute However, in Example 3, the oven temperature was changed to 70 ° C. under headspace conditions.
<GC conditions>
Temperature: 40 ° C (2 minutes) ⇒ Temperature rise (3 ° C / min) ⇒ 180 ° C ⇒ Temperature rise (10 ° C / min) ⇒ 220 ° C
Inlet: 200 ° C
Split ratio 10: 1
Average linear velocity: 28 cm / sec However, in Example 3 and Example 4, the temperature and the split ratio were changed as follows under the GC conditions.
Temperature: 40 ° C (8 minutes) ⇒ Temperature rise (3 ° C / min) ⇒ 180 ° C ⇒ Temperature rise (10 ° C / min) ⇒ 220 ° C
Split ratio 20: 1
<MS conditions>
Ionization method: Electron ionization method (EI)

[Quantitative determination of isovaleric aldehyde]
Based on the peak height (or peak area) of isovaleric aldehyde obtained from the above analysis results, the quantitative value (ppm) of isovaleric aldehyde was determined as follows.
A propylene glycol solution of isovaleric aldehyde of known concentration was prepared and added to a headspace vial as a standard sample. The sample and standard sample were tested by HSS-GC-MS under the above conditions, and the peak height (or peak area) of the sample and standard sample was determined.
Amount of isovaleric aldehyde (ppm)
= Standard sample concentration (ppm) x Sample peak height (or peak area) / Standard sample peak height (or peak area)
In Example 1, the evaluation was performed based on the peak heights of isovaleric acid and isovaleric aldehyde. In Examples 2 to 4, quantitative values were determined based on the peak area of isovaleric aldehyde.

Example 1
Relationship between the intensity of foot odor and the amount of isovaleric aldehyde and isovaleric acid According to the method for evaluating the intensity of foot odor, sampling from the foot, and the method for analyzing the amount of isovaleric acid and isovaleric aldehyde, subject 10 The name foot odor was evaluated and analyzed. The results of the evaluation and analysis are summarized in FIG. 1 and FIG. In FIG. 1, 10 subjects are arranged on the horizontal axis, the “foot odor intensity” of each subject is plotted with ●, and the “peak height of isovaleric aldehyde” of each subject is plotted with ■. ing. In FIG. 2, 10 subjects are arranged on the horizontal axis, the “foot odor intensity” of each subject is plotted with ●, and the “peak height of isovaleric acid” of each subject is plotted with ■ on the vertical axis. Yes.
As can be seen from FIG. 2, isovaleric acid is not observed particularly where the foot odor intensity is low, and cannot be an indicator of the foot odor intensity. On the other hand, as can be seen from FIG. 1, the amount of isovaleric aldehyde shows a strong correlation with the intensity of foot odor in a wide range from where the intensity of foot odor is weak to where it is strong.
From the above, it can be seen that isovaleric aldehyde can be used as an excellent indicator for determining foot odor indicating the strength of foot odor.

Example 2
Evaluation of Deodorant Agent A deodorant agent (medicinal mentholatum reflair toe cream: Rohto Pharmaceutical) was applied to the subject's foot. Then, the designated socks (washed, 100% cotton) and shoes were put on and left for a certain time (6 hours). After leaving, fold a 2cm x 8cm test piece (100% cotton) between the thumb and forefinger, between the forefinger and middle finger, and between the middle and ring fingers, and then place the tape so that it does not come off. I wore rolls, socks and shoes. After another 2 hours, socks and test pieces were collected, the collected test pieces were inserted into a headspace analysis vial, and the amount (A) of isovaleric aldehyde adhering to the test pieces was analyzed.
Further, the same procedure as described above was performed without applying a deodorant agent to the subject's feet, and the amount (B) of isovaleric aldehyde adhering to the test piece worn by the subject was analyzed.
The amount of isovaleric aldehyde (A) was compared with the amount of isovaleric aldehyde (B) to examine whether the deodorant agent decreased the indicator for foot odor determination. When the index agent for foot odor determination was decreased by the deodorant, the deodorant was evaluated as having a deodorizing effect and / or a deodorizing effect. The results are shown in Table 1.

In test subject No.1, the right foot with deodorant applied has a foot odor intensity of 1, while the left foot without deodorant applied has a higher foot odor intensity of 3 and also produces isovaleric aldehyde. The amount was 4.0 times higher than the right foot. In subject No. 2, the same result was obtained, and the amount of isovaleric aldehyde generated was 2.8 times different.
From the above test results, it can be seen that the effect of the deodorant agent can be confirmed using the amount of isovaleric aldehyde as an index.

Example 3
Test of reduction rate of isovaleric aldehyde by plant extract Using the extract obtained from the plant described in Table 2, the reduction rate of isovaleric aldehyde was tested.
To a 20 mL headspace GC vial, add 0.5 mL of a 2 ppm isovaleric aldehyde / polyethylene glycol solution and 1 mL of the plant extract shown in Table 2 and suspend MonoLap (DCC-18) manufactured by GL Sciences into the vial. The gas inside was collected. The MonoTrap was taken out, put into a 20 mL headspace vial, 0.5 mL of polyethylene glycol was added and sealed, and subjected to ultrasonic treatment for 10 minutes to prepare a sample. Separately, 0.5 mL of polyethylene glycol solution of 2 ppm isovaleric aldehyde was treated in the same way as the sample, and the peak area of isovaleric aldehyde was measured with a headspace gas chromatograph mass spectrometer for the sample and the standard sample. did. The reduction rate of isovaleric aldehyde in each sample was calculated from the peak area of the isovaleric aldehyde of the standard sample relative to the sample. The results are shown in Table 2.

a1) Artemis Liquid (Ichimaru Falcos)
a2) Camellia Liquid (Ichimaru Falcos)
a3) Green tea liquid (Ichimaru Falcos)
a4) Falco Rex Peppermint B (Ichimaru Falcos)
a5) Falco Rex Achillea millefolus B (Ichimaru Falcos)
a6) Falco Rex Honeysuckle SB (Ichimaru Falcos)
a7) Falco Rex Rosemary B (Ichimaru Falcos)
a8) Falco Rex Sage B (Ichimaru Falcos)
a9) Salvia extract BG-J (Maruzen Pharmaceutical)
a10) Falco Rex Enmeiso B (Ichimaru Falcos)
a11) Falco Rex BX46 (Ichimaru Falcos)
a12) Falco Rex Eucalyptus B (Ichimaru Falcos)
a13) Marjoram extract BG (Maruzen Pharmaceutical)
a14) Falco Rex Novara B (Ichimaru Falcos)
a15) Abou extract BG-J (Maruzen Pharmaceutical)
a16) Green tea extract BGW (Maruzen Pharmaceutical Co., Ltd.)
a17) Hypericum extract BG (Maruzen Pharmaceutical Co., Ltd.)
a18) Hamamelis extract BG-J (Maruzen Pharmaceutical Co., Ltd.)
a19) Sakura extract B (Ichimaru Falcos)

  Many plant extracts, including those with known deodorant effects, were tested to reduce the odor of isovaleric aldehyde, but most plant extracts did not suppress odor as described above. It was. Surprisingly, however, only chamomile, mugwort and green tea extracts significantly suppressed the odor of isovaleric aldehyde.

Example 4
Test of Reduction Rate of Isovaleric Aldehyde by Adsorption Powder Using the adsorption powder described in Table 3, the reduction rate of isovaleric aldehyde was tested.
To a 20 mL headspace GC vial, 0.25 mL of a 2 ppm isovaleric aldehyde / polyethylene glycol solution and 0.2 g of the adsorbing powder described in Table 3 were added, and the sample was sealed and used as a sample. Separately, 1 mL of polyethylene glycol was added to 0.25 mL of a polyethylene glycol solution of 2 ppm isovaleric aldehyde as a standard sample, and the peak area of isovaleric aldehyde was measured with a headspace gas chromatograph mass spectrometer for the sample and the standard sample. did. The reduction rate of isovaleric aldehyde in each sample was calculated from the peak area of the isovaleric aldehyde of the standard sample relative to the sample. The results are shown in Table 3.

b1) ORGASOL 2002 EXD NAT COS (registered trademark) (Arkema Corporation)
b2) ORGASOL 2002 EXD NAT COS Type S (registered trademark) (Arkema Corporation)
b3) ORGASOL 4000 EXD NAT COS (registered trademark) (Arkema Co., Ltd.)
b4) Tospearl 2000B (registered trademark) (Momentive Performance Materials Japan GK)
b5) KMP-590 (Shin-Etsu Chemical Co., Ltd.)
b6) KSP-300 (Shin-Etsu Chemical Co., Ltd.)
b7) Matsumoto Microsphere M-305 QD7 (registered trademark) (Matsumoto Yushi Seiyaku Co., Ltd.)
b8) Matsumoto Microsphere M-305 QD7N (registered trademark) (Matsumoto Yushi Seiyaku Co., Ltd.)
b9) Gantz Pearl SI-020 (registered trademark) (Aika Industry Co., Ltd.)
b10) Gantz Pearl GMP-0820 (registered trademark) (Aika Industry Co., Ltd.)
b11) Gantz Pearl GS-1105 (registered trademark) (Aika Industry Co., Ltd.)
b12) Sunsphere H-51 (registered trademark) (AGC S-Tech Co., Ltd.)
b13) Sunsphere H-121 (registered trademark) (AGC S-Tech Co., Ltd.)
b14) God Ball N-15C (registered trademark) (AGC S-Tech Co., Ltd.)

From this test result, it can be understood that silicic anhydride, which is an inorganic adsorption powder, does not adsorb isovaleric aldehyde at all, whereas organic adsorption powder adsorbs isovaleric aldehyde and reduces odor. Among organic adsorbent powders, especially Nylon powder (Nylon-12, Nylon-6 / 12), ORGASOL 2002 EXD NAT COS, ORGASOL 2002 EXD NAT COS TypeS, ORGASOL 4000 EXD NAT COS (registered trademark: Arkema Co., Ltd.) is 50 It is understood that a high reduction rate of at least% is exhibited, and a remarkably strong deodorizing effect is exhibited against isovaleric aldehyde.
By combining adsorbent powder with the plant extract, the odor of isovaleric aldehyde can be further suppressed.

  The embodiment disclosed this time is to be considered as illustrative in all points and not restrictive. The scope of the present invention is defined by the terms of the claims, rather than the description above, and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims.

  By the deodorizer and the deodorizing method of the present invention, the odor of isovaleric aldehyde can be suppressed and odors such as foot odor and body odor can be suppressed. Further, since isovaleric aldehyde is a causative odor of foot odor, the foot odor can be suppressed by the deodorant and method of isovaleric aldehyde of the present invention.

Claims (4)

  An isovaleric aldehyde deodorant comprising at least one selected from the group consisting of an extract of an Asteraceae plant or a camellia plant and an organic adsorption powder.   The deodorizer for isovaleric aldehyde according to claim 1, wherein the asteraceae plant is mugwort or chamomile, and the camellia plant is tea tree.   The deodorizer of isovaleric aldehyde according to claim 1 or 2, wherein the organic adsorption powder is at least one selected from nylon powder.   A method for deodorizing odors containing isovaleric aldehyde by applying to the skin a preparation containing at least one selected from the group consisting of an extract of an Asteraceae plant or a camellia plant and an organic adsorption powder.