JP2002325828A - Deodorant and use thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a deodorant with excellent deodorizing effect against an odorous substance, a deodorizing composition, and deodorized food. SOLUTION: Using a function of the extract of Prince's Pine to suppress an odor such as a mouth odor, a body odor, a tobacco odor, etc., a deodorant containing the extract of Prince's Pine, a deodorizing composition aiming at applying to a human body, and a deodorized food can be provided.

Description

DETAILED DESCRIPTION OF THE INVENTION

TECHNICAL FIELD The invention of this application relates to a deodorant and a deodorant composition. More specifically, the invention of this application relates to a deodorant having an effective deodorizing effect on a wide range of malodors, which contains an extract of P. persica as an active ingredient, and a use thereof.

2. Description of the Related Art The odors emitted by humans include the components contained in human sweat, secretions from the skin and their oxides, axillary odor, foot odor, sweat odor, body odor, sulfuric acid, etc. There are known bad breath, feces and urine odor caused by substances such as compounds, putrefaction odor caused by specific components of decomposition products of organic substances, and the like. Conventionally, deodorizing or deodorizing methods include, for example, a method of masking an odor using an aromatic substance, a method of oxidizing and decomposing an odor using an oxidizing agent, and a method of neutralizing the odor using a neutralizing agent. A method of adsorbing an odor on activated carbon or the like has been adopted. For the purpose of suppressing body odor, various deodorants are formulated for cosmetics.For example, against isovaleric acid and sulfur compounds, which are the main components of axillary odor, weak alkalis such as antibacterial agents and zinc oxide Salts containing metals and the like are used (Fragrance Journal. 2000, 1, pp. 82-88). Further, as one of the changes in body odor associated with aging, it has become clear that there is a specific body odor in middle-aged and elderly people generated by the oxidative decomposition of sebum, and nonenal, an unsaturated aldehyde, has been identified as the main odor component. On the other hand, antioxidants, lipoxygenase inhibitors, antibacterial agents (JP-A-11-286423-25), and among sugars, trehalose (Fragrance Journal. 2000, 1)
0, p114-115) are known to exhibit a deodorizing effect.

However, although the deodorizing materials of the prior art are effective for a specific odor, they are not uniformly effective for a wide range of odor components. Also,
For the purpose of reducing bad breath and other in-vivo odors, deodorants containing cyclodextrins, chlorophylls and some plant extracts as active ingredients have been reported and patented for foods. However, its effect is not enough. The invention of this application has been made in view of the above circumstances, and is to provide a deodorant which is highly safe and has an excellent deodorizing effect against a wide range of odors and its use. It is an issue.

SUMMARY OF THE INVENTION The present invention provides a deodorant containing, as an active ingredient, an extract of Prunus magnolia as an invention for solving the above-mentioned problems. The deodorant of the present invention may be substantially an extract of P. persica or may be in a mixed form with other components. The deodorant of the present invention can be used for any offensive odors such as indoor odors (including toilets and entrances), vehicle odors,
Applicable to daily odors such as garbage odors, tobacco odors, odors in refrigerators and freezers, or odors derived from living bodies such as pet odors, body odors, foot odors, bad breath odors, and excrement odors Can be. Further, the invention of this application provides a deodorant composition containing an extract of St. John's wort and intended for application to the human body. This deodorant composition is, for example, an article such as a drug, a quasi-drug, and a cosmetic, and the odor of the article itself is removed or reduced, or the odor in the human body or its living environment is reduced by application to the human body or the like. It is a composition that can remove or reduce odor. The application further provides a food product containing an extract of P. persica. This food is a food in which the odor of itself is removed or reduced, but the odor (eg, bad breath) originating in the human body can be removed or reduced by ingesting the food. Hereinafter, embodiments of the invention will be described, and the invention of this application will be described in more detail.

DETAILED DESCRIPTION OF THE INVENTION PIPSISSEWA Ch
imaphila umbellate W. Barton is a perennial herb that grows in dry forests near the coast and is a member of the family Yarrow. It is produced in temperate regions such as North America, Europe and Siberia, and is distributed north of Ibaraki Prefecture in Japan. In the present invention, any of the whole plant, leaves, stems, roots, seeds, and the like of St. John's wort can be used. In addition, P. persica may be a fresh grass or a dried product. In addition,
This maggot or its extract has been used as a fragrance for herbal teas and candy that humans have ingested in the United States for a long time, and is therefore a safe material. The extract of St. John's wort can be obtained by a conventional method using an extraction solvent. That is, examples of the extraction solvent include water, alcohols (for example, lower alcohols such as methanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and ethyl acetate. Examples include esters, diethyl ether, dioxane, acetonitrile, xylene, benzene, chloroform and the like. These solvents may be used alone or in combination of two or more. When extracting again from the extraction residue, not only the same solvent but also another solvent may be used. The ratio of Pleurotus terrestris to the solvent at the time of extraction is not particularly limited, but the solvent is 1 to 1,0 parts per 1 part by weight of Pleurotus terrestris.
00 parts by weight, especially 5 to 100 parts by weight, in terms of extraction operation and efficiency. The extraction temperature is conveniently in the range from room temperature to the boiling point of the solvent under normal pressure. A general method is used as the extraction operation method. For example, an immersion method, a countercurrent extraction method, or the like may be used, and stirring may be used as needed. The solid is separated from the extraction mixture to obtain an extract. The extract as an active ingredient of the deodorant of the present invention is an extract obtained by such an operation or a concentrate thereof. Such an extract may be subjected to a treatment such as distribution or purification by various chromatography, if necessary. Further, this extract has a characteristic odor derived from a raw material plant. Although it is not an unpleasant odor, the odor derived from a raw material plant may be removed while maintaining the deodorizing effect. As the deodorizing operation, a general method such as an adsorption method using activated carbon, a steam distillation method, a deodorizing method by concentrating an aqueous solution, a supercritical fluid extraction method using carbon dioxide, a distribution method with an organic solvent, and the like can be adopted. In the deodorant of the present invention, the obtained extract can be used as an active ingredient as it is, but depending on the use, dosage form, form, etc. of the deodorant,
Those prepared by drying (spray drying, freeze drying, etc.), concentration (normal pressure, reduced pressure, membrane, etc.), or dilution can also be used. The deodorant of the present invention may be substantially an extract of Prunus brassicae alone, or may be a commonly known base component (for example, an oil agent, a surfactant, an ultraviolet absorber) depending on a desired form or dosage form. , Medicinal ingredients, alcohols, preservatives, dyes, fragrances, excipients, etc.) can be widely mixed and used as long as the desired effects are not impaired by the compounding. Furthermore, antibacterial agents, antioxidants, cyclodextrin, plant extracts such as carrot, perilla, mugwort, etc., which are conventionally known as deodorants, may be used in combination. In addition, the dosage form is wide, such as aqueous solution, solubilizing system, emulsifying system, powder / granular system, oil-liquid system, gel system, ointment system, aerosol system, water-oil 2-layer system, water-oil-powder 3-layer system, etc. Dosage forms can be taken. The deodorant composition of the present invention is an article intended for application to the human body, and contains an extract of Pleurotus terrestris as long as the original effect of the composition is not impaired. The deodorant composition has the odor of the composition itself removed or reduced owing to the excellent deodorant activity of the extracts of P. persica, and can be comfortably applied to the human body. Further, by applying the present invention to a human body, it is possible to remove or reduce the odor emitted by the human body and the odor in the living environment. These compositions include, for example, pharmaceuticals (external preparations, hair restorers, etc.), quasi-drugs (ointments, dentifrices, etc.), cosmetics (facial cleansers, emulsions, creams, gels, essences (cosmetics), packs, Basic cosmetics such as masks,
Makeup cosmetics such as foundations and lipsticks, oral cosmetics, aromatic cosmetics, hair cosmetics, body cosmetics, etc.]. The food of the present invention is a food in which a St. John's wort extract is blended within a range that does not impair its own taste and nutrients. These foods have their odors themselves removed or reduced, so that they can be taken comfortably and breath odor and the like are removed or reduced after eating. In addition, food forms (such as candy, chewing gum, jelly,
Nutritional supplements, drinks, etc.). The amount added of the extract of Streptomyces magnolia in these deodorant compositions and foods is not particularly limited, but 0.0001 to
10% by weight, preferably in the range of 0.01 to 5% by weight.

EXAMPLES Hereinafter, the present invention will be described in more detail and specifically with reference to examples and experimental examples, but the present invention is not limited to the following examples. Example 1 1,000 g of purified water was added to 100 g of Allium serrata, extracted at room temperature for 30 minutes, and then filtered to obtain an extract. This was concentrated under reduced pressure to dryness to obtain 11.5 g of an extract (extract powder). Example 2 Ethanol (1,000 ml) was added to whole plant of P. persica, extracted for 1 hour at room temperature, and filtered to obtain an extract. This was concentrated under reduced pressure to dryness to obtain 6.1 g of an extract (extract powder). Experimental Example 1: Deodorizing effect on sulfur compounds As a test for sulfur compounds, one of various odor-causing substances, the effect on methyl mercaptan, which is known for its low threshold value and is also the main component of bad breath, was investigated. Was. Place the sample in a 125 ml vial with 0.2 M phosphate buffer (pH
In 7.0), 5 ml of a liquid suspended at a concentration of 0.25% was added, methyl mercaptan was added so as to be 5 ppm, and the methyl mercaptan concentration after 0.3 minutes was measured by gas chromatography. The analysis conditions are as shown in Table 1. The reduction rate of methyl mercaptan was calculated by the following equation. Reduction rate (%) = (concentration after 0 minute−concentration after 30 minutes) / concentration after 0 minute × 100

[Table 1] As a result, as shown in Table 2, in the reduction rate of methyl mercaptan, the water extract of Pleurotus magnolia prepared by the method of Example 1 has a high deodorizing effect, and iron chlorophyll Na which is a known deodorant is used. And copper chlorophyll Na, catechin, and the like.

[Table 2] Experimental Example 2: Deodorizing effect on lower aldehydes The effect on lower aldehydes containing nonenal, a so-called aging odor, which is a body odor generated by aging of humans, is obtained by oxidizing palmito oleic acid by heating. It was measured. The method is palmito oleic acid 50mg,
Microcrystalline cellulose 500 mg, sample 100 mg, 1 M phosphate buffer (pH
6.0) 0.25 ml, 1 ml of water in a 25 ml vial, 105
The headspace gas after heating at 5 ° C. for 5 hours was measured under the conditions shown in Table 3 below.

[Table 3] As a result, comparing the relative value when the concentration when no additive was taken as 100, as shown in Table 4, the water extract of Pleurotus magnolia prepared by the method of Example 1 was known for its inhibitory effect on lower aldehydes. Trehalose was found to have a higher inhibitory effect.

[Table 4] Experimental Example 3: Deodorizing effect on lower fatty acid The deodorizing effect on lower fatty acid, which is known as one of the main components of body odor, was measured. First, a test solution was prepared by dispersing and dissolving a St. John's wort extract with water at 1%. Test solution 1.
9 ml was placed in a 3.8 L polyethylene bag, and 0.1 ml of isovaleric acid was added thereto. After filling the bag with air and shaking lightly, the isovaleric acid in the headspace gas after 30 minutes was measured using a gas detector tube (Komei Rikagaku Kogyo). As a result, as shown in Table 5, when compared with the relative value with respect to the concentration when the test solution was made into water, as shown in Table 5, Examples 1 and 2 were weaker than magnesium oxide generally used for controlling lower fatty acids.
It was found that the water and ethanol extracts of St. John's wort prepared by the above method had an effect of suppressing the concentration of isovaleric acid.

[Table 5] Experimental example 4: Deodorizing effect on body odors For 10 healthy men in their 20s and 60s, immediately after taking a bath, wipe the water of the whole body with a towel etc.
Spray the upper body with a liquid adjusted to 1% by weight with water. After gently wiping off, wear a test shirt for about 24 hours. The test shirt was washed in advance with water and 50% ethanol, washed again with water and deodorized. Approximately 24 hours later, the shirts were collected and subjected to a sensory evaluation by a specialized panel. As a control, a shirt which was sprayed with water instead of an aqueous solution of St. John's wort on the previous day and worn for about 24 hours was used. Six panelists rated the deodorizing effect on the following four levels. 1: Smell is stronger than before use 2: Smell is almost the same as before use 3: Smell is slightly reduced compared to before use 4: Smell is significantly reduced compared to before use Table 6 shows the result of calculating the average value of the evaluation scores of the ten panelists. From this result, it was found that the body odor was significantly reduced by spraying the Acacia serrata aqueous solution.

[Table 6] Experimental Example 5: Deodorizing effect on tobacco odor The tobacco odor deodorizing effect was evaluated by the following method. It was diluted and adjusted with 30% ethanol so that the water extract and the ethanol extract of St. John's wort were 1% by weight. About 0.3 g of the above sample was applied to 1 g of the hair tress, brushed and spread well. Dried at room temperature for 1 hour. The hair bundle was transferred to a 200 ml Erlenmeyer flask, and 10 ml of cigarette smoke (collected by suction from the filter side with a syringe) was injected thereinto and left for 15 minutes. The hair bundles were transferred to a petri dish, and the odor was sensory evaluated by six specialized panels. As a control, the same procedure was performed for a sample not coated. The deodorizing effect was evaluated in four stages. 1: worse than non-coated sample 2: almost the same as non-coated sample 3: slightly improved compared to non-coated sample 4: considerably improved compared to non-coated sample The evaluation shows the average value of each panel. Also,
A comparison was made with a carrot extract (adjusted to 1% by weight) and a perilla extract (1% by weight) which are known as deodorants for tobacco odor. As a result, it was clarified that the St. John's wort extract exerts an excellent deodorizing effect on tobacco odor.

[Table 7] Example 3 A lotion having the following composition was produced. Composition Blended amount (% by weight) Glycerin 5.0% Oleyl alcohol 0.1% Polyethoxyethylene (20) sorbitan monolaurate 0.5% Oleifera magnolia water extract 0.3% Ethanol 10.0% Purified water 84.1% Perfume 100% Oleyl alcohol in purified water The water extract of St. John's wort was dissolved at room temperature to obtain an aqueous phase. Perfume, glycerin, polyoxyethylene (20), and sorbitan monolaurate were dissolved in ethanol and mixed with the previous aqueous phase to produce a lotion. Example 4 A transparent shampoo having the following composition was produced. Composition Blending amount (% by weight) Sodium alkyl ether sulfate (AES-Na) 16.0% Diethanolamide lauric acid 4.0% Propylene glycol 2.0% Methyl paraben 0.2% Water extract of Omega sorghum 0.2% Purified water 77.6% 100% Purified water at 70 ° C After heating and adding other components to dissolve uniformly, the mixture was cooled to produce a transparent shampoo. Example 5 A hair liquid having the following composition was produced. Composition Blending amount (% by weight) Polyethylene glycol (1500) 2.0% Polyoxyethylene (5) decyltetradecyl ether 2.0% Polyoxyethylene polyethoxypropylene oligosuccinate (3.EO) (20.PO) 2.0% Extract 0.2% Ethanol 65.2% Purified water 28.6% Fragrance Appropriate amount 100% A Phellinus serrata water extract was dissolved in purified water to prepare an aqueous phase, and the other components were dissolved in ethanol to prepare an alcohol phase. The aqueous phase was added to the alcohol phase, and the mixture was filtered with filter paper to produce a hair liquid. Example 6 A room colon having the following composition was produced. Composition Blended amount (% by weight) Polyoxyethylene (60) hydrogenated castor oil 1.5% Great squirrel water extract 1.0% Purified water 94.5% Perfume 3.0% 100% Polyoxyethylene (60) hydrogenated castor oil heated and dissolved in purified water Was dissolved, and a water extract and a perfume of St. John's wort were added thereto and dissolved to produce a room colon. Example 7 A chewing gum having the following composition was produced. Heat and soften the gum base and put it in a mixer, add sugar, glucose, starch syrup, flavoring agent, and water extract of Pleurotus magnolia,
After mixing uniformly and cooling, the mixture was molded to produce a chewing gum. Example 8 A candy having the following composition was produced. Sugar, starch syrup, and water were mixed and boiled down at a temperature of 150 ° C. After boiling, the mixture was cooled to 120 ° C., and a fragrance, citric acid, and a water extract of St. John's wort were added, mixed, and molded to produce candy.

As described above in detail, according to the invention of this application, a new deodorant containing an extract of P. persica as an active ingredient is provided. This deodorant is broad and excellent against various odors emitted by humans, for example, bad odors derived from sulfur compounds, lower aldehydes, lower fatty acids, etc., such as bad breath and body odor, or odors such as garbage and tobacco odors. It has a deodorizing effect.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/11 A61K 7/11 7/32 7/32 A61L 9/04 A61L 9/04 (72) Inventor Yuji Hinode 95-7 Minoki-cho, Fukuyama City, Hiroshima Prefecture Ikeda Food Research Institute Co., Ltd. (72) Inventor Hiroshi Miyamoto 95-7 Minoki-oki Town, Fukuyama City, Hiroshima Prefecture Ikeda Food Research Institute Co., Ltd. (72) Inventor Hiroshi Rikusha Fukuyama Hiroshima Prefecture 95-7 Minoki-cho, Ichida F-term (reference) in Ikeda Shokuken Co., Ltd.

Claims (3)

[Claims] 1. A deodorant comprising an extract of St. John's wort as an active ingredient. 2. A deodorant composition containing an extract of St. John's wort and intended for application to the human body. 3. A food containing an extract of St. John's wort.