JP5404985B2 - Fragrance composition for male hormone adjustment - Google Patents

Description

  The present invention relates to a fragrance composition for adjusting male hormones, and a cosmetic method.

  Male hormones (androgens) such as testosterone, androstenedione, and dehydroepiandrosterone not only have the effect of maintaining the functions of the reproductive organs in men, but are also biosynthesized in the adrenal gland and ovary in women and are produced along with the bloodstream in the body. It is known to have various physiological actions such as protein assimilation, blood cholesterol regulation, hyperglycemia suppression, K, Ca, P excretion suppression, sebaceous gland secretion promotion. Furthermore, it plays an important role as a precursor of female hormone biosynthesis, and it has been found that male hormone is effective in improving osteoporosis, hyperlipidemia, physical exhaustion, menopause, premenstrual syndrome, and the like. On the other hand, excessive male hormones cause increased sebum secretion and hirsutism. Therefore, by suppressing excessive male hormone activity, cosmetic benefits such as suppression of acne, prevention of shine due to sebum, suppression of unwanted hair, etc. Effects can be achieved.

  Hormones to adjust male hormones, such as direct administration of male hormones such as testosterone for the purpose of enhancing male hormones, or conversely, female hormones such as estradiol and estrone for the purpose of reducing the effects of male hormones Therapy is being performed. Further, testosterone 5α-reductase inhibitor that inhibits the action of testosterone 5α-reductase that reduces testosterone to active 5α-dihydrotestosterone (active 5α-DHT), and 5α-DHT generated from testosterone bind to the receptor. Various anti-androgen receptor inhibitors such as androgen receptor binding inhibitors that inhibit the above-mentioned are reported (for example, Patent Document 1), and hair growth inhibitors and sebum secretion inhibitors containing these anti-androgen agents are reported. Has been proposed.

  However, methods for adjusting male hormones using hormone therapy or anti-androgenic hormones as described above may adversely affect hormone balance and may disrupt the homeostasis. In addition, due to its side effects and safety issues, it is considered unsuitable for application to cosmetics that are used over a long period of time. Until now, a male hormone adjustment method that can be applied to cosmetics and foods and that can be applied for a long time with few side effects has not yet been developed.

On the other hand, until now, studies on the effects of fragrance fragrances on endocrine mainly relate to effects on stress-related hormones such as cortisol, and there has been almost no investigation on the effects of fragrances on sex hormones. It is only reported about the influence which a specific fragrance | flavor has on a female hormone (estradiol) level (nonpatent literature 1).
JP 2002-363085 A Masamitsu Kato et al., JSH Journal 27 (1), 63-67, (2004)

  In view of the circumstances as described above, an object of the present invention is to provide a fragrance composition capable of adjusting male hormones, which is highly safe and can be used for a long period of time.

  The present inventor changes the concentration of testosterone, a major male hormone, in the body fluid by acting on the homeostasis maintenance function through olfactory stimulation by smelling the scent of a specific fragrance (essential oil) ( It has been found that it can be increased or decreased), and the present invention has been completed. Testosterone (17β-hydroxy-4-androsten-3-one) is central to male hormone (androgen) metabolism and androgenic activity, and is also a precursor of female hormone (estradiol) in body fluids. By adjusting the testosterone concentration, it is possible to ameliorate various symptoms caused by excessive male hormone activity and various symptoms on which male hormones act effectively. Testosterone secretion is controlled by the central nervous system, such as the hypothalamus and the anterior pituitary gland, and the testosterone is fed back to the hypothalamus and anterior pituitary gland. It regulates negative secretion of gonadotropin-releasing hormone and gonadotropin and maintains homeostasis in the living body. Therefore, it is considered that the balance of male hormones can be adjusted by stimulating the feedback regulation mechanism of testosterone through olfactory stimulation by a fragrance.

  The fragrance composition for male hormone adjustment of the present invention comprises one or more fragrance components that change the testosterone concentration in the body fluid.

  The cosmetic method for adjusting male hormones of the present invention is characterized in that the scent of one or more fragrance components that change the testosterone concentration in the body fluid is smelled.

  In the present specification, “to change the testosterone concentration in body fluid” means that when the subject smells the fragrance component of the subject, for example, blood It means changing (increasing or decreasing) the testosterone concentration in any bodily fluid of a subject such as plasma, serum, saliva, lymph, tissue fluid and the like. In addition, the collection site | parts of those body fluids are not limited. Testosterone is produced in the testis, adrenal gland, ovary, etc., secreted into the blood, then circulates in the body along with the bloodstream, and moves to saliva and other biological tissues at a constant rate. And other testosterone concentrations in each body fluid are considered to have a correlation.

  In one embodiment of the present invention, the fragrance component used in the fragrance composition or cosmetic method of the present invention is a fragrance component that increases the testosterone concentration in body fluids. Examples of such perfume ingredients include basil oil, clary sage oil, eucalyptus oil, lavender oil, ginger oil, and rose oil.

  In another embodiment of the present invention, the fragrance component used in the fragrance composition or the cosmetic method of the present invention is a fragrance component that lowers the testosterone concentration in body fluids. Examples of such perfume ingredients include pettigrain oil, oris oil, bergamot oil, pepper oil, orange oil, yarrow oil, cardamom oil, and rosemary oil.

  The composition for external use of this invention is characterized by including the above fragrance | flavor compositions. In the present specification, the “external composition” is a concept encompassing all compositions applied to the skin (including the scalp, hair, and nails), such as basic cosmetics, makeup cosmetics, and hair cosmetics. Cosmetics such as cosmetics, skin or hair cleansing agents, and various pharmaceuticals or quasi-drugs such as ointments and dentifrices. The dosage form is also not particularly limited. For example, an aqueous solution system, a solubilization system, an emulsification system, an oil liquid system, a gel system, a paste system, an ointment system, an aerosol system, a water-oil two-layer system, a water-oil-powder 3 Includes any dosage form, such as a layer. Preferably, the composition for external use of the present invention is a cosmetic.

  Moreover, the miscellaneous goods or clothing of this invention is characterized by including the above fragrance | flavor compositions.

  The fragrance composition or cosmetic method of the present invention appropriately adjusts the balance of male hormones in a living body by using a feedback control mechanism of testosterone by the living body itself through an olfactory stimulus by a fragrance component that changes the testosterone concentration. Can do. Therefore, it is possible to prevent or ameliorate various symptoms related to the loss of male hormone balance more simply and safely. For example, by using the perfume composition of the present invention or various products containing the same, or by the cosmetic method of the present invention, symptoms such as increased sebum secretion and hypertrichosis caused by excessive male hormone activity, and conversely Symptoms such as osteoporosis, hyperlipidemia, physical exhaustion, menopause, and premenstrual syndrome can be improved.

  The fragrance component used in the present invention is not particularly limited as long as it changes the testosterone concentration in any body fluid such as blood, plasma, serum, saliva, lymph fluid, tissue fluid, etc. Any of natural fragrances, synthetic fragrances, semi-synthetic fragrances and the like may be used. Moreover, such a fragrance | flavor component can be prepared by arbitrary extraction methods, distillation methods, a synthesis method, etc., and you may use what is marketed. Although the specific fragrance | flavor component is mentioned above as preferable in using in this invention, these are only illustrations and this invention is not limited to these fragrance | flavor components. Moreover, such a fragrance | flavor component may be used individually by 1 type, or may be used in combination of 2 or more type.

  In addition, although all the fragrance | flavor components quoted as an illustration are marketed, the fragrance | flavor component made preferable below is demonstrated easily.

As the basil oil basil oil, for example, an essential oil obtained by steam distillation of whole plant of Lamiaceae (Ocimum basilicum L.) can be used.

Clarisage oil As the clary sage oil, for example, an essential oil obtained by steam-distilling flower ears or whole plants of the family Lamiaceae (Salvia sclarea L.) can be used.

As the eucalyptus oil , for example, an essential oil obtained by steam distillation of leaves and twigs of the genus Eucalyptus such as Eucalyptus globulus can be used.

Lavender oil As the lavender oil, for example, an essential oil obtained by steam distillation of Lavandula officinalis flowers can be used.

As the ginger oil , for example, an essential oil obtained by steam distillation of a dried ginger (Zingiber officinale) rhizome can be used.

As the rose oil , for example, an essential oil obtained by steam distillation of a flower of the genus Rose, such as a rose family (Rose damascena), can be used.

As pettigrain oil , for example, Citrus aurantium, so-called bitter orange leaves, essential oil obtained by steam distillation of twigs can be used.

As Oris oil Oris oil, for example, an essential oil obtained by pulverizing rhizomes of iris family (iris pallida, Iris germanica, Iris florentina) for 2 to 3 years after harvesting, solvent extraction or steam distillation is used. be able to.

As the bergamot oil , for example, an essential oil obtained by squeezing the peel of Citrus bergamia Risso et Poit can be used.

As the pepper oil , for example, an essential oil obtained by steam-distilling the fruits of the pepper family (Piper nigrum L) can be used.

As the orange oil , for example, essential oil obtained by squeezing the fruit skin of Citrus sinensis, so-called sweet orange, can be used.

As the yarrow oil , for example, an essential oil obtained by steam distillation of the whole plant of Achillea millefolium can be used.

As cardamom oil , for example, an essential oil obtained by steam distillation of dried fruits of Elettaria cardamomum can be used.

Rosemary oil As the rosemary oil, an essential oil obtained by steam-distilling flowers and leaves of Lamiaceae (Rosmarinus officinalis) can be used.

  Each blending amount of the fragrance component for changing the testosterone concentration in the fragrance composition of the present invention is appropriately selected depending on the type of the selected fragrance component, other blended components, and further the use, Although it does not specifically limit, Usually, it is 0.001-100 mass% with respect to the total mass of a fragrance | flavor composition, Preferably, it is 0.01-100 mass%.

  The fragrance composition for adjusting male androgen of the present invention contains one or two or more fragrance ingredients that change the testosterone concentration as described above by an ordinary fragrance means, and any other fragrance in an appropriate ratio. And may be prepared so as to have a suitable incense.

  Further, the perfume composition for adjusting male hormones of the present invention may be of any form as long as the perfume component is vaporized and can be inhaled, and is not particularly limited by the form of the dosage form. .

  Although the perfume composition for male hormone adjustment of the present invention may be used alone, it can be included in various objects. In addition to the androgen-adjusting fragrance composition of the present invention, an optional component can be further included depending on the type of the object. Moreover, you may use together the fragrance | flavor of this invention with the chemical | medical agent which has another male hormone regulatory action.

  For example, when the object is a composition for external use, its dosage form (eg, liquid, powder, granule, aerosol, solid, gel, etc.) or product form (eg, cosmetics, pharmaceuticals, pharmaceuticals) Depending on the quasi-drug etc., any component usually contained in such an external composition may be included together with the fragrance composition for adjusting male hormones of the present invention.

  In addition, although it does not limit as cosmetics which are one of the aspects suitable as an external composition containing the fragrance composition for male hormone adjustment of this invention, For example, perfume, eau de toilette, eau de cologne, cream, milky lotion, lotion , Foundations, powdered white powder, lipstick, soap, shampoo / rinse, body shampoo, body rinse, body powder, bath preparation, and the like.

  Also, for example, for any miscellaneous goods such as fragrance, deodorant, aroma candle, incense, stationery, wallet, bag, shoes, etc., and for any clothing such as underwear, clothes, hats, stockings, socks, etc. The androgen-adjusting fragrance composition of the invention can be included. The fragrance composition of the present invention may be added to these materials, or the fragrance composition of the present invention may be added to these products.

  Furthermore, as long as the effects of the present invention are obtained, the male hormone-adjusting fragrance composition of the present invention may be used in inhaled products such as inhaled pharmaceuticals, beverages, foods and the like.

  In addition, although the various usage aspect of the fragrance | flavor composition for male hormone adjustment of this invention was illustrated, it is not limited to them, As long as the effect of this invention can be achieved, it can be used in arbitrary aspects. Further, in addition to the fragrance composition for adjusting male hormones of the present invention, general fragrance components can be blended according to specific embodiments as long as the effects of the present invention are not impaired.

  The blending amount of the fragrance composition for male hormone adjustment of the present invention in the object can be appropriately selected depending on the kind of the fragrance component constituting the fragrance composition and the object, and is not particularly limited, for example, testosterone concentration The total amount of the fragrance component that changes the content is 0.0001 to 50% by mass, more preferably 0.001 to 20% by mass, and still more preferably 0.001 to 20% by mass with respect to the total mass of the object. 01 to 10% by mass.

  In the cosmetic method of the present invention, “scenting the scent of the fragrance component” means stimulating the sense of smell by inhalation of the vaporized fragrance component, and the method and means thereof are not particularly limited. For example, the target fragrance An ingredient or an external composition containing it may be applied directly to the skin, or directly inhaled, or a fragrance, a deodorant, an aroma candle, an incense, a stationery, a purse, a bag containing the target fragrance ingredient The scent may be made to smell through any miscellaneous goods such as shoes, or any clothing such as underwear, clothes, hats, stockings, and socks.

  In addition, the specific application of the fragrance composition for male hormone adjustment of the present invention, the object blended therewith, and the beauty method of the present invention is not particularly limited as long as it relates to male hormone adjustment. For example, when a fragrance component that increases the testosterone concentration is included, it can be applied to improve osteoporosis, hyperlipidemia, physical exhaustion, menopause, premenstrual syndrome, and the like. Also, when it contains a fragrance ingredient that lowers the testosterone concentration, it can be used to prevent or improve acne, suppress sebum secretion, prevent or improve dandruff and itching in the scalp, nourish hair, prevent or improve alopecia, suppress hair growth, etc. Applicable.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated concretely, this invention is not limited to the following Example.

Examination of the effect of fragrance ingredients on testosterone concentration Measured over time the testosterone concentration in saliva with and without the smell of various fragrance ingredients , and examined the effect of various fragrances on testosterone concentration did. Testosterone in the blood is transferred to saliva at a certain ratio, and it is known that the concentration of testosterone in saliva is highly correlated with that in blood, and it is possible to collect samples noninvasively and easily The testosterone concentration in the body fluid was represented by the testosterone concentration in the saliva. The experimental procedure will be specifically described below.

Saliva Collection Saliva collection was performed in a constant temperature room at a room temperature of 24 ° C. and a humidity of 50%. In female subjects in their twenties (two fragrances each), first, a cotton sheet containing no fragrance was put on the nose for 60 minutes in a resting state, and saliva was collected at the start of the experiment and every 15 minutes thereafter (control sample). Then, after resting for 30 minutes, the same subject was allowed to smell the scent by applying cotton soaked with each fragrance for 60 minutes under the nose. Similarly, saliva was collected at the start of the experiment and every 15 minutes thereafter ( Perfume display sample). Saliva was collected by gargle 30 minutes before the start of the experiment, and about 2 ml of saliva was collected in a saliva collection tube. The collected saliva was stored frozen at −80 ° C. until analysis.

Measurement of testosterone concentration The concentration of testosterone in saliva was measured according to the following procedure. That is, the saliva sample stored frozen at −80 ° C. is thawed and centrifuged at 1000 rpm for 10 minutes, and then the supernatant is diluted with an assay buffer attached to the measurement kit to measure the testosterone concentration in the saliva. The testosterone ELISA kit (manufactured by R & D Systems) was used for quantification.

The average value of testosterone concentration in five samples taken every 15 minutes between 0 minutes and 60 minutes (ie, 5 times after 0, 15, 30, 45, 60 minutes) for the control sample and the fragrance presentation sample, respectively. The testosterone concentration in the control sample and the testosterone concentration in the fragrance-presenting sample were obtained. For each individual, the relative testosterone concentration was calculated by the following formula, and the average value (each fragrance n = 2) was obtained:

Relative concentration = testosterone concentration in the perfume display sample / testosterone concentration in the control sample

The results are shown in FIG.

  When smelling basil oil, clary sage oil, eucalyptus oil, lavender oil, ginger oil, or rose oil, the relative testosterone concentration becomes greater than 1, and these perfume ingredients have the effect of increasing the testosterone concentration. I understood that.

  On the other hand, if you smell the scent of pettigrain oil, oris oil, bergamot oil, pepper oil, orange oil, yarrow oil, cardamom oil, or rosemary oil, the relative testosterone concentration will be less than 1, and these perfume ingredients It has been found that it has the effect of reducing the testosterone concentration.

  Although the results are not shown, nutmeg oil, star anise oil, geranium oil, chamomile oil, funnel oil, and neroli oil, which were evaluated in the same way, change the testosterone concentration even if they smell the scent. I could not.

  Below, the specific prescription example of the fragrance composition for male hormone adjustment of this invention is shown as an Example. In addition, all compounding quantities are represented by the mass% with respect to the composition whole quantity.

Example 1
Fragrance composition for male hormone adjustment (1)
(1) Basil oil 5.0
(2) Clarisage oil 2.0
(3) Lavender oil 3.0
(4) Eucalyptus oil 1.5
(5) Ginger oil 0.5
(6) Lemon oil 2.0
(7) Dihydromyrsenol 3.0
(8) Linalool 5.0
(9) Phenylethyl alcohol 2.0
(10) Citronellol 1.0
(11) Geraniol 0.5
(12) Lilianar 1.5
(13) Beta ionone 2.5
(14) Allyl amyl glycolate 0.3
(15) Sandalwood oil 2.0
(16) Helional 2.5
(17) Hedion 20.0
(18) ISO E Super 10.0
(19) Galaxolide 50% BB 15.0
(20) Linalyl acetate 7.0
(21) Ambroxan 0.2
(22) Remaining triethyl citrate

The fragrance composition of this example increased the testosterone concentration in the body fluid.

Example 2
Fragrance composition for male hormone adjustment (2)
(1) Bergamot oil 20.0
(2) Orange oil 10.0
(3) Rosemary oil 10.0
(4) Cardamom oil 1.0
(5) Yarrow oil 1.5
(6) Pepper oil 0.5
(7) Oris concrete 8% 0.5
(8) Dihydromyrsenol 1.0
(9) Linalool 3.0
(10) Citronellol 1.0
(11) Geraniol 1.0
(12) Lilianal 2.0
(13) Allyl amyl glycolate 0.1
(14) Helionar 1.0
(15) Hedion 15.0
(16) Iso E Super 7.0
(17) Galaxolide 50% BB 10.0
(18) Linalyl acetate 5.0
(19) Lilal 2.0
(20) Remaining triethyl citrate

The fragrance composition of this example reduced the testosterone concentration in the body fluid.

  Below, the formulation example of the typical product form of the composition for external use containing the fragrance | flavor composition for male hormone adjustment of this invention or miscellaneous goods is shown as an Example. In addition, all compounding quantities are represented by the mass% with respect to the product whole quantity.

Example 3
Lotion (Formulation Example 1)
(1) Glycerin 2.0
(2) Dipropylene glycol 2.0
(3) PEG-60 hydrogenated castor oil 0.3
(4) Trimethylglycine 0.1
(5) Preservative appropriate amount (6) chelating agent appropriate amount (7) dye appropriate amount (8) perfume composition (Example 1 or 2) 0.05
(9) Purified water remaining

Example 4
Lotion (Formulation Example 2)
(1) Alcohol 30.0
(2) Butylene glycol 4.0
(3) Glycerin 2.0
(4) PPG-13 decyltetrades 24 0.3
(5) Octylmethoxycinnamate 0.1
(6) Menthol 0.2
(7) Tocopherol acetate 0.1
(8) Chelating agent Appropriate amount (9) Dye Appropriate amount (10) Fragrance composition (Example 1 or 2) 0.01
(11) Purified water remaining

Example 5
Emulsion (Formulation Example 1)
(1) Stearic acid 2.0
(2) Cetyl alcohol 1.5
(3) Vaseline 4.0
(4) Squalane 5.0
(5) Glycerol tree 2-ethylhexanoate 2.0
(6) Sorbitan monooleate 2.0
(7) Dipropylene glycol 5.0
(8) PEG 1500 0.3
(9) Triethanolamine 0.1
(10) Preservative Appropriate amount (11) Fragrance composition (Example 1 or 2) 0.2
(12) Remaining amount of purified water

Example 6
Emulsion (Formulation Example 2)
(1) Ethyl alcohol 10.0
(2) Cyclomethicone 0.1
(3) Butylene glycol 5.0
(4) Dimethicone 3.0
(5) Glycene 0.1
(6) Menthol 1.0
(7) Trimethylsiloxysilicic acid 0.1
(8) Caffeine 1.0
(9) Trimethylglycine 1.0
(10) Xanthan gum 0.001
(11) Hydroxyethyl cellulose 0.1
(12) Fermented soybean extract 1.0
(13) Lauryl betaine 0.5
(14) Carbomer 0.2
(15) Chelating agent Appropriate amount (16) Paraben Appropriate amount (17) Benzoic acid Appropriate amount (18) Fragrance composition (Example 1 or 2) 0.1
(19) Iron oxide appropriate amount (20) Caustic potash 0.05
(21) Dicalcium glycyrrhizinate 0.01
(22) Pyridoxine hydrochloride 0.01
(23) Ascorbic acid glucoside 0.01
(24) Arbutin 3.0
(25) Yukinoshita extract 0.1
(26) Water remaining

Example 7
Emulsion (Formulation Example 3)
(1) Butylene glycol 4.0
(2) Propylene glycol 4.0
(3) Carbomer 0.2
(4) Caustic potash 0.2
(5) Behenic acid 0.5
(6) Stearic acid 0.5
(7) Isostearic acid 0.5
(8) Glyceryl stearate 1.0
(9) Glyceryl isostearate 1.0
(10) Behenyl alcohol 0.5
(11) Squalane 5.0
(12) Trioctanoin 3.0
(13) Phenyltrimethicone 2.0
(14) Batyl alcohol 0.5
(15) Dicalcium glycyrrhizinate 0.01
(16) Preservative Appropriate amount (17) Chelating agent Appropriate amount (18) Pigment Appropriate amount (19) Fragrance composition (Example 1 or 2) 0.15
(20) Remaining amount of purified water

Example 8
Emulsion (Formulation Example 4)
(1) Glycerol 3.0
(2) Xylitol 2.0
(3) Carbomer 0.1
(4) Caustic potash 0.1
(5) Glyceryl isostearate 1.0
(6) Glyceryl stearate 0.5
(7) Behenyl alcohol 1.0
(8) Batyl alcohol 1.0
(9) Hardened palm oil 2.0
(10) Vaseline 1.0
(11) Squalane 5.0
(12) Erythrityl octoate 3.0
(13) Cyclomethicone 1.0
(14) Preservative appropriate amount (15) chelating agent appropriate amount (16) perfume composition (Example 1 or 2) 0.2
(17) Purified water remaining amount (18) tranexamic acid 1.0
(19) Pantothenyl ethyl ether 0.5
(20) Nicotinamide 0.1
(21) Trehalose 0.1
(22) Rosemary extract 0.1
(23) Vitamin A 0.1
(24) Ascorbic acid glycoside 0.001
(25) Raspberry extract 1.0
(26) Ogon extract 0.001
(27) Oat extract 0.01

Example 9
Emulsion (Formulation Example 5)
(1) Ethanol 2.0
(2) Cyclomethicone 10.0
(3) Glycerin 5.0
(4) Dibutylene glycol 1.0
(5) Dimethicone 1.0
(6) Cornstarch 4.0
(7) Mineral oil 2.0
(8) Trimethylsiloxysilicic acid 5.0
(9) Polyethylene glycol 3.0
(10) Lactic acid menthyl 0.1
(11) PEG-60 hydrogenated castor oil 1.0
(12) Aminopropyl dimethicone 1.0
(13) Xanthan gum 0.01
(14) Tocopherol acetate 0.01
(15) Caffeine 0.1
(16) Sodium hyaluronate 0.1
(17) Fermented soybean extract 0.01
(18) Hamamelis extract 0.01
(19) Dokudami Extract 0.01
(20) Carbomer 0.3
(21) Matacrylic acid alkyl copolymer 0.2
(22) HEDTA appropriate amount (23) preservative appropriate amount (24) perfume composition (Example 1 or 2) 0.3
(25) Pigment appropriate amount (26) Caustic potash 0.15
(27) Aminomethylpropanol 0.05
(28) Water remaining

Example 10
Emulsion (Formulation Example 6)
(1) Ethanol 15.0
(2) Cyclomethicone 6.0
(3) Butylene glycol 0.5
(4) Dimethicone 1.0
(5) Glycerin 1.0
(6) Polyethylene glycol 1.0
(7) Lactic acid menthyl 1.0
(8) Menthol 0.1
(9) Trimethylsiloxysilicic acid 1.0
(10) Caffeine 0.5
(11) Trimethylene glycine 0.1
(12) Xanthan gum 0.1
(13) Hydroxyethyl cellulose 0.1
(14) Fermented soybean extract 0.01
(15) Tocopherol acetate 0.05
(16) Lauryl betaine 0.01
(17) Dehydrated algae extract 0.01
(18) Dokudami extract 0.01
(19) Red algae extract 0.01
(20) Green algae extract 0.01
(21) Cellulose spray 1.0
(22) PEG-60 glyceryl isostearate 1.0
(23) Isostearic acid 1.0
(24) Carbomer 0.1
(25) Alkyl methacrylate alkyl polymer 0.1
(26) EDTA 0.1
(27) Sodium metaphosphate 0.1
(28) Phenoxyethanol 0.2
(29) Paraben 0.2
(30) Fragrance composition (Example 1 or 2) 0.45
(31) Iron oxide (red) 0.02
(32) Menthyl glyceryl ether 0.01
(33) Water remaining

Example 11
Cream (Formulation Example 1)
(1) Glycerin 10.0
(2) Butylene glycol 5.0
(3) Carbomer 0.1
(4) Caustic potash 0.2
(5) Stearic acid 2.0
(6) Glyceryl stalate 2.0
(7) Glyceryl isostearate 2.0
(8) Vaseline 5.0
(9) Preservative appropriate amount (10) Antioxidant appropriate amount (11) Fragrance composition (Example 1 or 2) 0.3
(12) Purified water Remaining amount (13) Chelating agent Appropriate amount (14) Pigment Appropriate amount (15) Stearyl alcohol 2.0
(16) Behenyl alcohol 2.0
(17) Palm hardened oil 2.0
(18) Squalane 10.0
(19) 4-methoxysalicylic acid K 3.0

Example 12
Cream (formulation example 2)
(1) Glycerol 3.0
(2) Dipropylene glycol 7.0
(3) Polyethylene glycol 3.0
(4) Glyceryl stearate 3.0
(5) Glyceryl isostearate 2.0
(6) Stearyl alcohol 2.0
(7) Behenyl alcohol 2.0
(8) Liquid paraffin 7.0
(9) Cyclomethicone 3.0
(10) Dimethicone 1.0
(11) Octyl methoxycinnamate 0.1
(12) Na hyaluronate 0.05
(13) Preservative appropriate amount (14) Antioxidant appropriate amount (15) Fragrance composition (Example 1 or 2) 0.4
(16) Purified water remaining amount (17) Chelating agent appropriate amount (18) Pigment appropriate amount

Example 13
Gel (1) Ethyl alcohol 10.0
(2) Glycerin 5.0
(3) Butylene glycol 5.0
(4) Carbomer 0.5
(5) Aminomethylpropanol 0.3
(6) PEG-60 hydrogenated castor oil 0.3
(7) Menthol 0.02
(8) Preservative appropriate amount (9) chelating agent appropriate amount (10) perfume composition (Example 1 or 2) 0.1
(11) Purified water remaining

Example 14
Aerosol (Formulation Example 1)
(1) Glycerin 2.0
(2) Dipropylene glycol 2.0
(3) PEG-60 hydrogenated castor oil 0.3
(4) HPCCD 1.0
(5) Preservative appropriate amount (6) chelating agent appropriate amount (7) dye appropriate amount (8) perfume composition (Example 1 or 2) 0.2
(9) Purified water appropriate amount (10) LPG remaining amount

Example 15
Aerosol (Prescription Example 2)
(1) Alcohol 15.0
(2) Butylene glycol 2.0
(3) Glycerin 1.0
(4) PPG-13 decyltetrades 24 0.1
(5) Silver supported zeolite 1.0
(6) Chelating agent Appropriate amount (7) Dye Appropriate amount (8) Fragrance composition (Example 1 or 2) 0.15
(9) Purified water remaining amount (10) LPG 40.0

Example 16
Aerosol (Prescription Example 3)
(1) Ethanol 60.0
(2) Lactic acid menthyl 0.1
(3) Sodium lactate 0.1
(4) Tocopherol acetate 0.01
(5) Lactic acid 0.01
(6) Caffeine 0.01
(7) Fennel extract 1.0
(8) Hamelis Extract 1.0
(9) Dokudami Extract 1.0
(10) Dipropylene glycol 1.0
(11) Nitrogen gas 0.9
(12) Polyoxyethylene polyoxypropylene 1.0
Decyl tetradecyl ether
(13) Butylene glycol 2.0
(14) Tocopherol 0.05
(15) Fragrance composition (Example 1 or 2) 0.1
(16) PEG-60 hydrogenated castor oil 0.1
(17) Water remaining

Example 17
Shampoo (1) Lauryl polyethylene (3)
Sulfate sodium salt (30% aqueous solution) 30.0
(2) Sodium lauryl sulfate ester salt (30% aqueous solution) 10.0
(3) Palm oil fatty acid diethanolamide 4.0
(4) Glycerin 1.0
(5) Preservative appropriate amount (6) Fragrance composition (Example 1 or 2) 0.5
(7) Dye appropriate amount (8) sequestering agent, pH adjuster appropriate amount (9) remaining amount of purified water

Example 18
Rinse (1) Silicone oil 3.0
(2) Liquid paraffin 1.0
(3) Cetyl alcohol 1.5
(4) Stearyl alcohol 1.0
(5) Stearyltrimethylammonium chloride 0.7
(6) Glycerin 3.0
(7) Fragrance composition (Example 1 or 2) 0.5
(8) Dye, preservative appropriate amount (9) Purified water remaining

Example 19
Body shampoo (1) Lauric acid 2.5
(2) Myristic acid 5.0
(3) Palmitic acid 2.5
(4) Oleic acid 2.5
(5) Cocoyl diethanolamide 1.0
(6) Glycerin 20.0
(7) Caustic potash 3.6
(8) Dye Appropriate amount (9) Fragrance composition (Example 1 or 2) 0.5
(10) metal ion sequestering agent appropriate amount (11) remaining amount of purified water

Example 20
Fragrance (1) Alcohol 75.0
(2) Purified water Residual (3) Dipropylene glycol 5.0
(4) Perfume composition (Example 1 or 2) 10.0
(5) Antioxidant 8.0
(6) Appropriate amount of dye (7) Appropriate amount of UV absorber

Here, “fragrance” is obtained by dissolving the perfume composition of the present invention in alcohol (for example, ethyl alcohol) or aquatic alcohol. The fragrance contains 1% to 99% by mass of the fragrance composition of the present invention. The mixing ratio of water and alcohol is in the range of 50:50 to 0: 100. Fragrances can contain solubilizers, softeners, fumestanes, thickeners, bacteriostats, or other materials commonly used in cosmetics.

Example 21
Room Fragrance (1) Alcohol 80.0
(2) Purified water Residue (3) Antioxidant 5.0
(4) Fragrance composition (Example 1 or 2) 3.0
(5) 3-Methyl-3-methoxybutanol 5.0
(6) Dibenzylidenesorbitol 5.0

Example 22
Incense (1) Tab powder 75.5
(2) Sodium benzoate 15.5
(3) Fragrance composition (Example 1 or 2) 5.0
(4) Eucalyptus oil 1.0
(5) Fennel oil 1.0
(6) Purified water residue

Example 23
Bath salt (1) Sodium sulfate 45.0
(2) Sodium bicarbonate 45.0
(3) Hyssop oil 9.0
(4) Perfume composition (Example 1 or 2) 1.0

Example 24
Massage Gel (1) Erythritol 2.0
(2) Caffeine 5.0
(3) Oat extract 3.0
(4) Glycerin 50.0
(5) Carboxyvinyl polymer 0.4
(6) Polyethylene glycol 400 30.0
(7) Ethylenediamine hydroxyethyl triacetic acid trisodium 0.1
(8) Polyoxylene (10) Methyl polysiloxane copolymer 2.0
(9) Squalane 1.0
(10) Potassium hydroxide 0.15
(11) Fragrance composition (Example 1 or 2) 1.0

Example 25
Massage cream (1) Solid paraffin 5.0
(2) Beeswax 10.0
(3) Vaseline 15.0
(4) Liquid paraffin 41.0
(5) 1.3-butylene glycol 4.0
(6) Glycerol monostearate 2.0
(7) POE (20) sorbitan monolaurate 2.0
(8) Borax 0.2
(9) Caffeine 2.0
(10) Preservative appropriate amount (11) Antioxidant appropriate amount (12) Fragrance composition (Example 1 or 2) 1.0
(13) Purified water remaining

Example 26
Aromatic fiber A microcapsule (particle size of 50 μm or less, in a microcapsule) in which the fragrance composition of the present invention is encapsulated in a cuproammonium cellulose solution (cellulose concentration 10% by weight, ammonium concentration 7% by weight, copper concentration 3.6% by weight). 50% by weight of the essential oil is added within a range of 0.1 to 20% by weight based on the weight of the cellulose, mixed, then spun in accordance with a normal wet spinning method, subjected to a refining process and a drying process, Sex fiber was obtained.

  The composition for external use or miscellaneous goods of these Examples changed the testosterone concentration in the body fluid by a use test in a typical usage mode of each product form.

The graph which shows the effect of the fragrance | flavor component with respect to a testosterone density | concentration.

Claims (2)

A male hormone regulator containing basil oil as an active ingredient that acts on the testosterone regulatory mechanism through olfactory stimulation by inhalation to increase the testosterone concentration in body fluids . An androgen regulating agent that acts on the testosterone regulatory mechanism by olfactory stimulation by inhalation and lowers the testosterone concentration in body fluids, comprising an essential oil selected from the group consisting of petigrain oil, oris oil, and yarrow oil as an active ingredient.

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