JP2005029776A - Perfume composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a perfume composition accelerating secretion of a female hormone. <P>SOLUTION: This perfume composition accelerates the secretion of the female hormone, wherein the composition contains ambrette seed oil, ambrettolide, muscone, and civetone. The composition and a product containing the composition, such as an external preparation for skin, general merchandise, and food, are each utilizable for accelerating the secretion of the female hormone. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a fragrance composition that promotes secretion of female hormones, and further relates to an external preparation for skin, miscellaneous goods, food, and the like containing the fragrance composition.

  In general, it has been known from conventional studies that female hormones are closely related to the action of female hormones (see, for example, Patent Document 1, Non-Patent Documents 1 and 2). Female hormones include follicular hormone (estrogen) and progesterone secreted from the ovary, and these act antagonistically or synergistically to control the action as female hormones.

  Menopause is mainly caused by menopause, which is accompanied by discomfort that is unknown to others, called indefinite complaints, and is thought to occur when the balance of female hormones is disturbed. Specific symptoms may include physical symptoms such as hot face, hotness, head ache, nausea, stomach upset, swollen body, irritation, lethargy, anxiety, and depression. There are social symptoms, such as psychological symptoms, not wanting to meet people, staying home, and ranting to family and friends, but women are seriously worried about these symptoms. Treatment methods for climacteric disorders include administration of hormonal agents and tranquilizers, but all of these treatments have side effects and are not suitable as treatments. Others include psychotherapy, exercise therapy, and stress relief, but there are currently no effective treatments for all symptoms. Estrogen secretion is known to decline rapidly during menopause, and some symptoms of climacteric disorder are said to be due to decreased estrogen. Improvement can be expected.

In addition, the following effects can be considered as an effect of estrogen on the skin. First, estrogen works on skin fibroblasts and promotes biosynthesis of collagen and hyaluronic acid. Collagen synthesis is known to decrease with age, and collagen with a high degree of cross-linking increases. However, female hormones promote collagen synthesis and are young as soon as they are biosynthesized. The effect of increasing the proportion of low cross-linked collagen has been observed. This leads to the effect of keeping the dermis young and tensioning the skin. Next, since estrogen antagonizes with male hormones, it has a lowering effect on sebaceous gland hyperactivity activated by male hormones. This effect can be applied to symptoms of hyperlipidemic glands such as acne. Furthermore, estrogen has the effect of reducing UV stress. When male and female mice are irradiated with the same dose of ultraviolet light, the damage is greater in males, and it has been suggested that female estrogen is resistant to ultraviolet light (see Non-Patent Document 3). In addition, the decrease in female hormones increases the activity of collagen-degrading enzymes by ultraviolet rays and leads to wrinkles and tarmi. Therefore, promoting the secretion of female hormones leads to the prevention of skin aging such as wrinkles and tarmi (non- (See Patent Document 4).
Japanese Patent Laid-Open No. 06-211682 Hideki Mizunuma, “Aging Phenomena in Women, especially Changes in Menopause”, Modern Physician, vol. 18, no. 9, 1998-9, p. 1007-1010 Edited by Shiseido, “Hint III for Beautiful Ages”, Kouryudo, p. 135-155 Norihisa Kawai, 1 other, “Application of isoflavones to skin care”, Fragrance Journal 2000-12, p. 129-131 Hiroshi Tanaka and 4 others, “Effects of Cucurbitaceae plants on skin changes in ovariectomized mice by long-term ultraviolet irradiation”, 18th Annual Meeting of the Japanese Society of Pharmaceutical Sciences, p.122

  As described above, estrogen can be expected to have a useful effect in the fields of menopause and skin care, but it is difficult to administer the hormone itself to the human body or by external skin preparations from the viewpoint of safety or regulation. It is believed that there is. That is, an object of the present invention is to provide a fragrance composition that promotes secretion of female hormones.

  In view of the above, the present inventors have conducted extensive research and found that the perfume composition, amblet seed oil and macrocyclic musk, have an excellent female hormone secretion promoting action.

Amblet seed oil (concrete oil, concrete, absolute)
The common names of the plants that produce the amblet seeds are called scented oysters. This plant is an annual plant of Malvaceae native to tropical Asia. Its scientific name is Abelmoschus moschatus Moench, which resembles okra but has an oval shape with a length of about 8 cm. The so-called amblet seed oil includes amblet seed concrete, amblet seed absolute, and amblet seed oil. Ambret seed concrete is obtained by extracting the amblet seed with a volatile solvent and then removing the solvent. The concrete obtained by further steam distillation of this concrete is the Amblet Seed Absolute. It is. Usually, in the method of collecting natural fragrances, the absolute is obtained by a method of extracting concrete with alcohol, but in this plant, the one obtained by steam distillation of the ambret seed concrete is an ambret seed absolute. This is done to remove fatty acids contained in the concrete. Ambret seed oil is obtained by simply steam-distilling the seeds of amblet, but it contains a small amount of palmitic acid. Therefore, this essential oil requires a aging period of several months, and it is said that fatty acid odor is suppressed by aging. The aroma is rich and sweet, floral skiing and wine-like. Contains 15% Ambrettolide as the main scent component (from Hideki Yoshigi, “Introduction to Fragrances”, Fragrance Journal, p.213-215).

Ambrettolide
A rich, extremely floral musky scent with a sweet, slightly sticky, colorless oil. It is a useful retention agent for fragrances, and the retention effect can be confirmed only by adding 0.01% to alcohol. Although it is a retention agent, it is said to have an effect of enhancing fragrance (from Hideki Yoshigi, “Introduction to Fragrance”, Fragrance Journal, p. 215).

Muscone
It is the main incense component of natural fragrance and is contained in an amount of 0.5 to 2.0%. Although it is an elegant musk crystal, the general commercial product is a viscous liquid. The most desirable musk fragrance, used in high-quality fragrances, and used in small amounts in flavors (from Motoichi Into, “Synthetic fragrance chemistry and product knowledge”, Chemical Industry Daily, p. 492-495).

Civetone
It is contained 2-3% in the main body of fragrance of ghost cat incense (civet). A natural product is a cis isomer with respect to a double bond, but a commercially available synthetic product is a mixture of isomers mainly composed of a trans isomer. It is a colorless liquid of diffusible animal and musk fragrance (from Motoichi Inushi, “Synthetic Fragrance Chemistry and Product Knowledge”, Chemical Industry Daily, p. 496).

  The macrocycle of the present invention refers to those having 14 to 17 carbon atoms.

  The macrocyclic musk of the present invention includes, for example, Muscone, Civetone, Cyclopentadecanone, Cyclohexadecenone (1-Cyclohexadecen-1-one), Cyclopentadecanolide, and Cyclopentadecanide. Ambrettolide, cyclohexadecanolide, 10-oxahexadecanolide, 11-oxahexadecanolide, 12-oxahexadecanolide, 12-oxahexadecanolide, 12-oxahexadecanolide 12-Oxahexadecanolide, Ethylene brush rate (Ethylene b) assylate), such as ethylene dodecanedioate (Ethylenedodecanedioate), and the like. Of these, amblet lid, muscone, and civeton are preferable.

The blending amount of these fragrance compositions in the present invention is appropriately selected depending on the type of the fragrance composition to be selected and the relationship with other blending components, and is not particularly limited. The standard is as follows (% indicates% by weight). If it is 0.001% by weight or less, there may be a case where a sufficient effect cannot be obtained in the secretion promotion effect of female hormones. is there.
Product type Preferred fragrance rate (%) More preferred fragrance rate (%)
Cream 0.001-3.0 0.05-1.0
Lotion 0.001-1.0 0.01-0.3
Milk lotion 0.001-2.0 0.02-0.5
Foam pack 0.001-1.0 0.03-0.5
Aerosol 0.001-30 0.01-10
Bath agent 0.001-20 0.1-10
Fragrance 0.001-100 0.1-30
Room fragrance 0.001-100 0.01-20
Incense 0.001-50 0.05-30
Lozenges 0.001-0.5 0.01-0.1
Textile products 0.001-5.0 0.1-1.0

  The fragrance composition of the present invention can be used for any of foods such as cosmetics, pharmaceuticals, skin external preparations such as quasi-drugs, incense, space sprays, miscellaneous goods such as textiles, and lozenges, It is not limited to these uses. As an external preparation for skin, for example, it is preferably used in the form of cream, lotion, milk lotion, essence, pack, foam, powder, ointment and the like. As miscellaneous goods, it is preferable to use in forms such as incense, room fragrance, foam-like fragrance, and textile products. Textile products include clothes such as trousers, skirts, underwear such as pants, bras, shirts, socks, stockings, girdle, swimwear, towels, handkerchiefs, masks, gloves, duvets, carpets, curtains, pillowcases, interior and exterior of automobiles Products and industrial materials. Among these textile products, in particular, underwear that is in direct contact with the skin is preferable in that it is easy to feel a scent by friction and a scent is easily generated by body temperature. As food, it is preferable to use it for lozenges, drop agents, etc., which are in a form that makes it easy to feel the scent when entering the mouth. Moreover, it is also possible to use several usage methods in combination.

  The fiber material of the fiber product in the present invention is not particularly limited, and natural fibers such as cotton, silk and wool, regenerated fibers such as rayon, semi-synthetic fibers such as acetate, polyester, nylon, polyethylene, polypropylene, polyurethane, and vinylon. , Synthetic fibers made of polyaramid or the like or a mixture thereof, and composite fibers of these fibers are used. Examples of the form include yarns, knitted fabrics, woven fabrics, nonwoven fabrics, and laminates thereof.

  The method for fixing the fragrance composition in the present invention to the fiber product is not particularly limited. For example, the fragrance composition in the present invention is microencapsulated, dissolved or dispersed in water or an organic solvent, spray method, pad method, immersion. It can be fixed by attaching to a fiber material by a method, a coating method, a printing method or the like and then drying. Moreover, in order to improve durability more, you may use a crosslinking agent, a binder, etc. together as needed. Furthermore, it may be used in combination with other additives that impart functionality, for example, by using together with fiber processing agents such as softeners, antistatic agents, antibacterial deodorants, etc. Become.

  For such external preparations for skin, sundries, foods, various commonly used ingredients such as powders such as chalk, talc, kaolin, starch, sucrose, corn starch, oils or oils such as mineral oil, vegetable oil, silicone oil, gelatin, Natural polymer materials such as agar and methyl cellulose, polyacrylic compounds, polymethacrylic acid compounds, synthetic polymer materials such as melamine resins and urea resins, sorbitan trioleate, sorbitan tristearate, glycerol monooleate, polymeric silicone Emulsifiers such as surfactants, preservatives such as methyl paraben, antioxidants such as butylhydroxytoluene, lubricants such as glycerol, sorbitol, dibutyl phthalate, gelatin, polyethylene glycol, bases such as triethanolamine or sodium hydroxide Accompanying lactic acid Buffers, glycerol ethers and surfactants such as synthetic, animal or vegetable ceramides, beeswax, ozokerite wax, waxes such as paraffin, thickeners, activity enhancers, coloring agents, etc. as necessary They can be used in combination.

  In addition to the fragrance composition that promotes the secretion of female hormones, general fragrance ingredients can be blended according to the specific modes that the present composition can take as long as the effects of the present invention are not impaired.

  The perfume composition of the present invention can be used by itself, and can also be used in combination with other female hormone secretion promoters, for example, Koei Ekine, Toki, Katsuki, Peony skin, Yamayaku, etc. .

  The fragrance composition of the present invention and the external preparation for skin, miscellaneous goods, food and the like containing the fragrance composition were excellent in the effect of promoting female hormone secretion.

  Hereinafter, the perfume composition that promotes secretion of female hormones according to the present invention will be described in more detail with reference to production examples. The present invention is not limited to these. In the production examples, “%” means “% by weight”.

Production Example 1 Cream 1. Glycerin 3%
2. Dipropylene glycol 7%
3. Polyethylene glycol 3%
4). Glyceryl stearate 3%
5. Stearyl alcohol 2%
6). Liquid paraffin 7%
7. Cyclomethicone 3%
8). Dimethicone 1%
9. Ethylparaben 0.5%
10. Ethylenediamine hydroxyethyl trisodium triacetate 0.01%
11. Purified water Residual 12. Ambret lid (manufactured by Takasago International Corporation)
(Fragrance) 0.1%
(Manufacturing method) Components 4 to 9 are dissolved by heating and mixed, and kept at 70 ° C to obtain an oil phase. Ingredients 1 to 3 and ingredients 10 and 11 are dissolved by heating and mixed, and kept at 75 ° C. to obtain an aqueous phase. The aqueous phase is added to the oil phase to emulsify, and the mixture is cooled while stirring. The component 12 is added at 45 ° C, and further cooled to 30 ° C to obtain a product.

Production Example 2 Fragrance Alcohol 75%
2. Dipropylene glycol 1%
3. Muscon (Nippon Filmenich Co., Ltd.) 5%
4). Blended fragrance (floral bouquet tone) 15%
5. Antioxidant appropriate amount 6. 6. UV absorber appropriate amount Appropriate amount of dye 8. Purified water The remaining (manufacturing method) components 1 to 6 and components 7 and 8 are uniformly dissolved and mixed together, followed by filtration to obtain a product.

  Here, the “fragrance” is obtained by dissolving the fragrance composition of the present invention in alcohol (for example, ethyl alcohol) or aqueous alcohol. The mixing ratio of water and alcohol is in the range of 50:50 to 0: 100. Fragrances can contain solubilizers, softeners, humectants, thickeners, bacteriostats, or other materials commonly used in cosmetics. Using normal scenting means, add fragrance ingredients that harmonize with the fragrance composition of the present invention to modulate and finish by adding retentivity and body, or suitable top note, middle note, last note In combination, it is possible to prepare a formulation that emits an attractive fragrance over time.

Production Example 3 Kneaded perfume Dipentaerythritol fatty acid ester 20%
2. Micro crostalin wax 20%
3. 4% paraffin
4). Ambret seed oil (manufactured by Takasago International Corporation) 3%
5. Blended fragrance (green fruity tone) 5%
6). Appropriate amount of dye 7. Vaseline The remaining (manufacturing method) components 1 to 7 are uniformly dissolved at 70 ° C and cooled to 30 ° C to obtain a product.

Production Example 4 Room fragrance Alcohol 80%
2. Antioxidant 5%
3. Ambret lid (manufactured by Takasago International Corporation) 10%
4). Blended fragrance (Citrus / Fresh) 5%
5. 5. UV absorber appropriate amount Appropriate amount of dye 7. Purified water The remaining (manufacturing method) components 1 to 5 and components 6 and 7 are uniformly dissolved, and both are mixed to obtain a product.

Production Example 5 Insense Tab powder 75%
2. Sodium benzoate 15%
3. Sibeton (Nippon Filmenich Co., Ltd.) 1%
4). Blended fragrance (Oriental) 15%
5. Purified water The remaining (manufacturing method) components 1 to 5 are uniformly mixed, and after kneading with a kneader, the molded product is dried to obtain a product.

Production Example 6 Lotion 1. Glycerin 3%
2. 1,3-butylene glycol 3%
3. Trimethylglycine 0.1%
4). Methylparaben 0.2%
5. Ethylenediaminetetraacetic acid trisodium 0.02%
6). Appropriate amount of dye 7. Muscon (Nippon Filmenich Co., Ltd.) 0.02%
8). POE (18) oleyl alcohol ether 0.5%
9. Purified water Residue (manufacturing method) Components 1 to 4 and components 5 to 9 are uniformly dissolved, and both are mixed and filtered to obtain a product.

Production Example 7 Milk lotion Stearic acid 2%
2. Cetyl alcohol 0.5%
3. Beeswax 2%
4). POE (10) monooleate 1%
5. Octyl methoxycinnamate 2%
6). Triethanolamine 0.8%
7. Glycerin 7%
8.1,3-butylene glycol 0.5%
9. Ethylparaben 0.3%
10. Ethylenediamine hydroxyethyl trisodium triacetate 0.01%
11. Ambret seed oil (manufactured by Takasago International Corporation) 0.05%
12 Purified water The remaining (manufacturing method) components 1 to 7 are heated and dissolved and mixed, and kept at 70 ° C. to obtain an oil phase. Ingredients 8 to 10 and ingredient 12 are dissolved by heating and mixed, and kept at 75 ° C. to obtain an aqueous phase. The aqueous phase is added to the oil phase to emulsify, and the mixture is cooled while stirring. The component 11 is added at 45 ° C, and further cooled to 30 ° C to obtain a product.

Production Example 8 Powder bathing agent Sodium bicarbonate 48%
2. Ambret lid (manufactured by Takasago International Corporation) 3%
3. Sodium sulfate The remaining (manufacturing method) components 1 to 3 are uniformly mixed to obtain a product.

Production Example 9 Liquid bath 1. Tetraoleic acid POE (30) Sorbitol 14%
2. Sorbitan sesquioleate 3%
3. Squalane 10%
4). Jojoba oil 20%
5. Ethylparaben 0.1%
6). Liquid paraffin residue 7. POE (2) oleyl ether 3%
8). Sibeton (Nippon Filmenich Co., Ltd.) 2%
(Manufacturing method) Components 1-6 are uniformly dissolved at 60 ° C., and components 7 and 8 are uniformly dissolved to obtain a product.

Production Example 10 Lozenges 60% powdered sugar
2. Cornstarch residue Sucrose fatty acid ester 3.0%
4). Muscon (Nippon Filmenich Co., Ltd.) 0.002%
5. Menthol 0.01%
(Manufacturing method) Components 1 and 2 are granulated with a fluid bed granulator, then components 3 to 5 are added, and molded with a tableting machine to obtain a product.

Production Example 11 Stockings (manufacturing method) Ambret seed oil (manufactured by Takasago International Corporation) and medium chain triglycerides mixed and dissolved in a weight ratio of 1/1 to 50 parts by weight of this microcapsule core substance with methyl methacrylate 10 parts by weight and 0.02 parts by weight of benzoyl peroxide were dissolved, and then dispersed in 100 parts by weight of a 1% by weight aqueous solution of sodium lauryl sulfate at 70 ° C., and the particle size of the core material was controlled by propeller stirring. A dispersion was obtained. The dispersion was polymerized at 70 ° C. for 4 hours while introducing nitrogen, and microencapsulated by an in-situ polymerization method to obtain a microcapsule dispersion. The dispersion was washed, filtered and dried to prepare a microcapsule for fiber treatment. 10 parts by weight of the fiber processing microcapsules are dispersed in 30 parts by weight of an epoxy-modified dimethylsiloxane aqueous emulsion serving as a binder to prepare a fiber processing microcapsule dispersion. The stockings are immersed in the dispersion and dried to obtain microcapsules. Were fixed to obtain a microcapsule-fixed fiber (stockings).

The effect of the present invention will be described by the following experiment.
Experimental Example 1 The secretion promotion effect of female hormones in the fragrance composition of the present invention The amount of 17β-estradiol, which is a typical estrogen, in saliva was measured. Saliva after scenting 6 subjects with scent of Ambret Seed Oil, Amblet Lido, Muscon, and Sibeton, before scenting, and after scenting for 8 minutes and then resting for 10 minutes The concentration of 17β-estradiol in was compared.

  After the subject was seated on the chair and kept at rest, saliva was collected and used as a sample before presenting the scent. The subject who was in a resting state was sniffed with paper soaked with scent for 8 minutes, and saliva was collected again 10 minutes later. Saliva was sterilized with cotton in the mouth and chewed for 1 minute, and the saliva contained in the cotton was squeezed out with a syringe and then centrifuged, and the supernatant was used as measurement saliva. 17β-estradiol in saliva was quantified using a 17β-Estradiol (E2) ELISA kit (Takeda Pharmaceutical Co., Ltd.). A microplate reader (Molecular Device Co., Ltd.) was used for measuring the absorbance value. Ambret seed oil (Takasago International Corporation), Ambret Lido (Takasago International Corporation), Muscon (Nippon Filmmenich Co., Ltd.), Sibeton (Nippon Filmmenich Co., Ltd.) are used as samples, and Lavender is used as a comparative example. Oil (Ve Manfis Fragrance Co., Ltd.) and lemon oil (Takasago Fragrance Co., Ltd.) were used.

  The results are shown in Table 1. As is clear from the table, the amount of estradiol in the saliva increased significantly after smelling the scent of Ambret Seed Oil, Amblet Lido, Muscone, and Civeton compared to before presenting the scent. It became clear that the scent of fragrances promoted the secretion of female hormones.

Experimental Example 2. Based on the prescription of Production Hormone Secretion Production Example 1 in the preparation containing the fragrance composition of the present invention, a cream was prepared by changing the kind and amount of the fragrance, and 2 g was applied to the back of the hand to the subject. I smelled it. Other than that was carried out similarly to Experimental Example 1, and the amount of 17β-estradiol in saliva was measured. The results are shown in Table 2 as average increase.

  As is apparent from the table, after smelling the scent of the preparation containing the fragrance of the present invention, the amount of estradiol in the saliva increases, and the fragrance of the fragrance of the present invention promotes the secretion of female hormones. Became clear.

Experimental Example 3. Experiments were carried out in the same manner as in Experimental Example 1 using stockings with a perfume adhered as in Production Example 11 of female hormone secretion promoting effect in a textile product to which the perfume composition of the present invention was affixed. The concentration of 17β-estradiol in the saliva was compared before wearing stockings and after wearing a scented stocking for 8 minutes and after resting for 10 minutes. The results are shown in Table 3 as average increases.

  As is clear from the table, after wearing the stockings to which the fragrance of the present invention is fixed, the amount of estradiol in the saliva is increased, and it is clear that the fragrance of the fragrance of the present invention promotes the secretion of female hormones. became.

  The fragrance composition of the present invention and the external preparation for skin, miscellaneous goods, food and the like containing the fragrance composition can be used for promoting female hormone secretion.

Claims (7)

  A fragrance composition characterized by promoting secretion of female hormones.   A fragrance composition for promoting the secretion of female hormones, characterized by comprising an ambret seed oil or a macrocyclic musk.   A fragrance composition according to claim 2, characterized in that the amblet seed oil is an ambret seed absolute or an amblet seed oil.   4. A fragrance composition according to claim 2 or claim 3, wherein the macrocyclic musk is an amblet lid, muscone, or civeton.   An external preparation for skin, miscellaneous goods, or food comprising the fragrance composition according to claim 1.   A fragrance composition for preventing skin aging, characterized by comprising an ambret seed oil and / or a macrocyclic musk.   A perfume composition for improving menopause, characterized by containing an amblet seed oil and / or a macrocyclic musk.