JP3951271B2 - Body fat burning accelerator - Google Patents

Description

  The present invention relates to a fragrance composition. More specifically, the present invention relates to a fragrance composition used for the purpose of increasing brown adipose tissue in the body, promoting the burning of body fat, or suppressing the accumulation of body fat or reducing body fat. About. Furthermore, this invention relates to the scented product which has said each effect by containing these fragrance | flavor compositions.

  Obesity not only causes beauty but also causes lifestyle-related diseases such as hypertension, hypertension, and diabetes, and is a national problem in advanced countries that are in a satiety state, coupled with an increase in medical expenses. Yes.

  Obesity is induced when the amount of energy consumed exceeds the amount of energy consumed. As a method of reversing this and eliminating obesity, a method of reducing the amount of energy intake by suppressing fat absorption by using a fat substitute or non-absorbable fat (for example, see Patent Document 1) Various methods for preventing obesity by promoting metabolism of fat inherent in the living body have been proposed.

  Regarding the latter method, as a substance that promotes metabolism of body fat, for example, Oolong tea polyphenol, capsaicin, and hydroxycitric acid contained in garcinia are known. Oolong tea polyphenols, when given to high-fat diet rats, increase fat excretion and, at the same time, activate lipolytic enzyme lipase. Capsaicin works on the brain and promotes adrenaline secretion from the adrenal glands. Moreover, it is said that hydroxycitric acid inhibits fat synthesis (refer to the column of prior art in Patent Document 2). It has also been suggested that plant-derived components containing capsaicin and caffeine have an effect of promoting fat metabolism and promoting fat decomposition (see Non-Patent Documents 1 and 2, etc.). Recently, it has been known that catechins contained in green tea, black tea, oolong tea, etc. have an effect of promoting the burning of body fat, and the scent of grapefruit oil has an effect of activating the sympathetic nerve, It has been proposed as a body fat combustion accelerator and anti-obesity fragrance composition that is safe for the human body (see, for example, Patent Documents 2 and 3).

Thus, conventionally, methods for increasing the heat production efficiency of the body and increasing the energy consumption by using materials that are safe for the human body have been attracting attention and studied as a method for preventing and eliminating obesity in a healthy manner. It is the actual situation.
U.S. Pat. No. 3,600,196 JP 2002-326932 A JP 2002-193824 A Yoshida et al., J. Nutr. Sci. Vitaminol 1988 Dec .; 34 (6) 587-594 Yoshioka et al., J. Nutr. Sci. Vitaminol 1990 Apr .; 36 (2) 173-178

  An object of the present invention is to provide a perfume composition that promotes the burning of body fat in accordance with the needs of the industry. Specifically, the present invention is a fragrance composition that can increase brown adipose tissue in the body by smelling the scent, a fragrance composition that can promote the burning of body fat by smelling the scent, and It is an object of the present invention to provide a fragrance composition capable of suppressing or reducing fat accumulation based on any of these functions. Furthermore, an object of this invention is to provide the scented product which has the said function by containing this fragrance | flavor composition.

  In order to solve the above-mentioned problems, the present inventors have been diligently paying attention to various plant essential oils. The scent of juniper oil increases the brown adipose tissue in the body and promotes fat burning. I found it to work. Such a juniper oil or a fragrance composition having the same and a product scented with the juniper oil are effective in preventing and eliminating obesity by suppressing fat accumulation or reducing body fat mass. I was convinced that it was available. The present invention has been completed based on such findings.

That is, the present invention is a fragrance composition used for various purposes described below:
Item 1. A perfume composition for increasing brown adipose tissue comprising or containing juniper oil.
Item 2. A perfume composition for promoting the burning of body fat, comprising or containing juniper oil.
Item 3. A perfume composition for suppressing body fat accumulation or reducing body fat mass comprising or containing juniper oil.

Further, the present invention is a scented product used for various purposes described below:
Item 4. A perfumed product for increasing brown adipose tissue containing juniper oil.
Item 5. A scented product containing juniper oil for promoting body fat burning.
Item 6. A scented product for body fat accumulation suppression or body fat content reduction containing juniper oil.

The present invention is described in detail below.
I. TECHNICAL FIELD The present invention relates to a fragrance composition used for the purpose of increasing brown adipose tissue, promoting body fat burning, suppressing body fat accumulation, or reducing body fat content.

  All of these fragrance compositions are made of juniper oil or contain juniper oil.

  Juniper oil is an essential oil that can be obtained by steam distillation of the fruit (fruit juice) of juniper (Juniperus communis L.) belonging to the cypress family. Such essential oils have been widely used as flavors of fragrances, liquor (gin), fresheners in the mouth [edited by the Japan Fragrance Association, Scent Encyclopedia, 214 (1989), Asakura Shoten], and are safe for the human body. It is a confirmed essential oil. In addition to bactericidal disinfection and diuretic effects, juniper oil is known to have a variety of useful effects (for example, tonicity, wind drive, detoxification, gastric activity, anti-neuropathy, antirheumatic) Based on this, it is used for the treatment of various diseases (aroma therapy).

  Juniper oil can be prepared by steam distillation of juniper berries as described above, but can also be obtained commercially. Note that juniper oil prepared by distilling berries and other parts such as twigs together is also included in the juniper oil targeted by the present invention.

  The fragrance composition of the present invention may be composed only of juniper oil, or may contain components other than the essential oils as long as the effects of the present invention are exhibited. Examples of components other than essential oils include other essential oils, perfumes, and bases and additives used in the preparation of perfume compositions.

  Here, the essential oil used in combination with juniper oil is not limited. However, in addition to the effect of the present invention, the obtained fragrance composition takes into account that juniper oil is an essential oil belonging to middle notes. It is preferable to select them. For example, benzoic oil, orange oil, grapefruit oil, cypress oil, sandalwood oil, geranium oil, milk perfume oil, bergamot oil, melissa oil, lime oil, lemongrass oil, rosemary oil, lavender oil, etc. Can do.

  When the fragrance composition of the present invention contains other components in addition to juniper oil, the content ratio of juniper oil is, for example, 0.1 to 99% (w / w) as long as the effect of the present invention is achieved. ) Can be selected appropriately.

  The perfume composition of the present invention is not particularly limited in its shape. For example, a solution dissolved in a lower alcohol having 1 to 6 carbon atoms such as ethanol, propyl alcohol or isopropyl alcohol, and a polyhydric alcohol such as propylene glycol or glycerin, which is used as a solvent for ordinary fragrances; gum arabic, tragacanth gum, etc. Natural gums or emulsions emulsified with glycerin fatty acid ester, sucrose fatty acid ester, etc .; natural gums such as gum arabic, coated with known materials as flavoring excipients such as gelatin and dextrin Powder form; Solubilized form (dispersed form) solubilized (dispersed) using a surfactant, etc .; Select any shape according to the purpose, such as microcapsules obtained by processing with a known encapsulating agent. Can be prepared according to conventional methods. Moreover, it can also be included by well-known excipient | fillers, such as a cyclodextrin, and sustained release property can also be given.

  As shown in Test Example 2 to be described later, the fragrance composition of the present invention comprising or containing juniper oil can increase brown adipose tissue in the body by sniffing its scent. Brown adipose tissue is an energy consuming organ that burns energy in the body and produces heat. Therefore, according to the fragrance | flavor composition of this invention, it is thought that energy metabolism is activated and the fat burning in a body can be accelerated | stimulated with increasing the brown adipose tissue in a body. As a result, it is possible to suppress the accumulation of fat in the body and create a constitution that is difficult to gain weight.

  In addition, as shown in Test Example 1 described later, the fragrance composition of the present invention comprising or containing juniper oil reduces the amount of neutral fat in the blood by sniffing its scent, and free fatty acids There is a tendency to increase. Moreover, as shown in Test Example 3, the amount of white adipose tissue decreases by sniffing the scent. Therefore, according to the fragrance composition of the present invention, it is considered that the body fat accumulated by promoting fat metabolism in the body can be reduced.

  Therefore, the fragrance composition of the present invention can be used for the purpose of increasing brown adipose tissue in the body, promoting burning of body fat, promoting metabolism of body fat, or suppressing accumulation of body fat or reducing the amount of body fat. .

II. Fragrance product The fragrance composition of the present invention can be blended in various products as a fragrance having the above functions. The present invention also provides a perfumed product containing the perfume composition of the present invention.

  In the present invention, the scented product means a product that contains the fragrance composition of the present invention for the purpose of fragrance or contains the fragrance composition of the present invention, and as a result, generates a scent. To do. Although it does not restrict | limit especially if it has these characteristics, As a fragrance | flavor product, for example, a fragrance | flavor, a cosmetics, an inhalation administration agent, a detergent for textiles, textiles, foodstuffs, a pharmaceutical, pharmaceutical part Examples include foreign products and daily necessities. Preferred are fragrances, cosmetics, inhalation administration agents, textile products and foods, and more preferred are fragrances, cosmetics and foods.

  Examples of the fragrance include those conventionally used as fragrances for indoor use, toilets, automobiles, entrances, bathrooms, closets, textiles such as clothes, and chiffon. In addition, what has a deodorizing effect is also contained in this fragrance | flavor. Various forms such as solid, semi-solid (jelly, gel, etc.), liquid, aerosol and the like are used as the fragrance.

  In addition to cosmetics, cosmetics include biological cleaning agents such as soaps and bathing agents, fragrances such as perfumes, toothpastes, liquid toothpastes, mouthwashes, mouth pets, and mouth fresheners. Examples of cosmetics include creams, milky lotions, cosmetic powders, body lotions, hair styling agents, hair shampoos, soaps, body soaps, antiperspirants, shampoos, rinses, perfumes, lotions, lipsticks, lip balms, sun creams. Examples include screens, massage oils, massage creams, and skin care oils.

  Examples of the inhalation administration agent include those that generate a fragrance near the nose by volatilization of a spray or a fragrance component and intentionally inhale the fragrance, for example, nasal drops, sprays, inhalation liquids, and the like.

  Examples of foods include the perfume composition of the present invention, and are intended to increase brown adipose tissue in the body, promote body fat burning, promote body fat metabolism, or suppress body fat accumulation or decrease body fat content. Can be listed as ingested. In order to efficiently obtain the effect of the scent component, those that stay in the mouth for a relatively long time and inhale the scent through the mouth, or those in which the scent component is inhaled before entering the mouth are preferable. Specific examples include confectionery such as gum, candy, gummi, and troche; frozen desserts and desserts such as yogurt and ice cream; soft drinks such as tea: fresheners in the mouth; supplements and the like.

  Examples of the detergent for textiles include anionic, cationic, nonionic or zwitterionic detergents, textile softeners, textile softeners, dryer textile softeners, and the like.

  Examples of the textile products include clothing such as underwear and outerwear, handkerchiefs and towels, rugs, bags and bags, and accessories.

  In addition, quasi-drugs include toothpastes, liquid toothpastes, mouthwashes, mouth pets, mouth fresheners, poultices, etc., and daily necessities (miscellaneous goods) such as kitchen detergents, heat absorption and cooling gel sheets. And other patches.

  The content of the fragrance composition of the present invention in the scented product is not particularly limited, and can be appropriately selected from the range of 0.1 to 99% (w / w) in terms of the content of juniper oil. However, since the effect of the fragrance composition of the present invention is affected by individual differences such as age, sex, psychological state, physical condition, and body fat mass, the fragrance is less than 0.1% (w / w). A scented product containing the composition may be used. Preferably it is 1 to 50% (w / w), more preferably 3 to 30% (w / w).

  In addition to the fragrance composition of the present invention, the fragrance can contain components such as bases and additives conventionally used in fragrances. As a base for a fragrance, those in the form of solid, liquid, semi-solid (jelly, gel, etc.), aerosol, etc. are common. Examples include water, ethanol, solid or liquid anionic, cationic, nonionic active agents, polymer agents, fats and oils, guar gum, xanthan gum, gum arabic, gellan gum, carrageenan, gelatin, agar and the like. Furthermore, it can be used in the form of a product impregnated with a carrier for holding such as a solid polymer (eg, polystyrene, polypropylene), calcium silicate or the like.

  In addition to the fragrance composition of the present invention, the cosmetic product can contain components such as bases and additives conventionally used in cosmetic products. Although it does not restrict | limit especially as a base, For example, water, ethanol, talc, gelatin, etc. are mentioned. Although it does not restrict | limit especially as an additive, For example, a moisturizer, a skin softener, an antiseptic | preservative, a solubilizer, etc. are mentioned.

  When the cosmetic is a perfume, the fragrance composition according to the present invention is used as it is without adding anything, or the fragrance composition of the present invention is dissolved in alcohol (for example, ethyl alcohol) or aqueous alcohol. Can be used. In the perfume, the fragrance composition of the present invention can be blended at a ratio of 0.1 to 99 (w / w)% in terms of the content of juniper oil. The compounding ratio of water and alcohol can be in the range of 50:50 to 0: 100 (volume ratio). The colon can contain solubilizers, softeners, humectans, thickeners, bacteriostats, or other materials commonly used in cosmetics. Using normal fragrance means, add fragrance ingredients that harmonize with the fragrance composition of the present invention to modulate and finish by adding retentivity and body, or suitable top note, middle note, base note In combination, it is possible to prepare a formulation that emits an attractive fragrance over time.

  In addition to the fragrance composition of the present invention, the inhalation administration agent can contain components such as bases and additives conventionally used in inhalation administration agents. Moreover, when using the gas for inhalation, the gas which has been used for the conventional inhalation administration agent can be used.

  In addition to the fragrance composition of the present invention, other components conventionally used in textile detergents can be used in the textile detergent.

  The scented product of the present invention contains juniper oil as its scent component. Therefore, according to the scented product of the present invention, the brown adipose tissue in the body can be increased. Along with this, it is considered that energy metabolism can be activated to promote fat burning in the body. As a result, it is possible to create a constitution that prevents fat accumulation by suppressing fat accumulation in the body. Moreover, according to the scented product of the present invention, it is considered that body fat accumulated by promoting fat metabolism in the body can be reduced. Therefore, the scented product of the present invention can be used for the purpose of increasing brown fat tissue in the body, promoting burning of body fat, promoting metabolism of body fat, or suppressing accumulation of body fat or reducing the amount of body fat. .

  As described above, according to the fragrance composition and the scented product of the present invention containing juniper oil as an active ingredient, brown adipose tissue in the body can be increased. Along with this, it is considered that energy metabolism can be activated to promote fat burning in the body. As a result, it is possible to create a constitution that prevents fat accumulation by suppressing fat accumulation in the body. Moreover, according to the fragrance composition and the scented product of the present invention containing juniper oil as an active ingredient, it is considered that the accumulated body fat can be reduced by promoting fat metabolism in the body. Therefore, the scented product of the present invention can be used for the purpose of increasing brown fat tissue in the body, promoting burning of body fat, promoting metabolism of body fat, or suppressing accumulation of body fat or reducing the amount of body fat. .

  EXAMPLES Hereinafter, although a test example and an Example are given and this invention is demonstrated, this invention is not limited to these Examples.

Test example 1
Wistar male rats were sniffed with plant essential oils (Juniper oil, grapefruit oil), and the effects of neutral and free fatty acids in the blood and body weight were examined. In addition, juniper oil (trade name: juniper berry oil, Ogawa Fragrance Co., Ltd.) and grapefruit oil (product name: grapefruit essential oil (white), Inabata Fragrance Co., Ltd.) are each 3% (w / w). It was dissolved in dipropylene glycol and used as a test essential oil. It is known that the scent of grapefruit oil has the effect of activating sympathetic nerves, and thereby has the effect of activating metabolism to reduce body weight (anti-obesity effect) (for example, Japanese Patent Application Laid-Open No. 2002-2002). 193824).

  Specifically, randomly selected male Wistar rats (5 weeks old, body weight 100-120 g) are divided into 3 groups (each group: 6 animals). The aroma emitted from each of the above juniper oil and grapefruit oil was naturally inhaled for 5 days (Juniper oil inhalation group, grapefruit oil inhalation group). In addition, dipropylene glycol was spontaneously inhaled for 5 days as a negative control in the third group of rats (non-inhalation group). In natural inhalation, each test essential oil or 100 μg of dipropylene glycol is impregnated in odor paper (7 mm × 50 mm, manufactured by Daiichi Pharmaceutical Co., Ltd.), and the rat naturally inhales the fragrance emitted from the odor paper. This was carried out by placing it on the upper part of the rat breeding cage for 5 days. During the test, rats were allowed to freely eat food and water, and food intake was recorded.

  Five days after spontaneous inhalation, the body weight was measured, and then the rats were sacrificed by ether anesthesia, blood was collected from the abdominal vena cava, and the amount of neutral fat and free fatty acid in the serum were measured. In addition, the amount of neutral fat and free fatty acid in serum were measured using Triglyceride E-Test Wako (Wako Pure Chemical Industries, Ltd.) and NEFA C-Test Wako (Wako Pure Chemical Industries, Ltd.), respectively. .

  The results are shown in Table 1 together with the total intake of food for 5 days (total intake g). In addition, the weight gain (g) shown in Table 1 indicates the weight gain when compared with the weight measured before the test for each rat. Each measured value in Table 1 is an average value ± standard deviation of measured values of rats (6 animals) in each group.

  As shown in Table 1, in the juniper oil inhalation group, the amount of neutral fat in the blood decreased significantly and the amount of free fatty acid tended to increase as compared with the non-inhalation group. This suggests that the Juniper oil inhalation group is leaning toward metabolism (decomposition of fat, use as an energy source) rather than synthesis and accumulation of fat (energy storage) in the body.

  As described above, it is known that grapefruit oil activates sympathetic nerves by smelling its scent, thereby activating metabolism and reducing body weight. As shown by the above results, juniper oil was much more effective in reducing the amount of neutral fat in the blood than such grapefruit oil. Although the Juniper oil inhalation group consumes more food than the grapefruit oil inhalation group, the rate of reduction of neutral fat in the blood is remarkably large. It was suggested that use as a source was promoted.

Test Example 2 Weight change of brown adipose tissue
Changes in the weight of brown adipose tissue were investigated when Wistar male rats were sniffed with juniper oil.

  Specifically, Wistar male rats (6 weeks old, body weight 125 to 145 g) randomly selected as in Test Example 1 were divided into 2 groups (each group: 6 animals). The aroma emitted from juniper oil was naturally inhaled for 8 days (Juniper oil inhalation group), and the rats in Group 2 were inhaled naturally for 8 days as a control (non-inhalation group). In addition, the natural inhalation method was carried out by placing the test essential oil or the odor paper impregnated with dipropylene glycol on the upper part of the rat breeding cage for 8 days as in Test Example 1. During the test, rats were allowed to freely consume food and water. On the 8th day after inhalation, the rats of each group were sacrificed by ether anesthesia, the abdomen was opened, the brown adipose tissue between the shoulder ribs was removed, and the weight was measured. The results are shown in Table 2. Table 2 also shows the results of determining the ratio of the brown adipose tissue to the body weight [(brown adipose tissue weight / body weight) × 100 (%)] for each group of rats. In addition, each measured value of Table 2 is the average value +/- standard deviation of the measured value of each rat (6 animals) of each group.

  As shown in Table 2, it was found that the weight of brown adipose tissue and the proportion of body weight in the juniper oil inhalation group significantly increased compared to the non-inhalation group. Brown adipose tissue is an energy consuming organ that burns energy in the body and produces heat, unlike white adipose tissue that functions as an energy storage. Therefore, an increase in brown adipose tissue in the body means that the body's energy metabolism is activated, resulting in a constitution that is difficult to gain weight. That is, from the above results, it was suggested that by sniffing juniper oil, brown adipose tissue increases, resulting in a constitution with good heat production efficiency and less fat.

Test example 3
The amount of protein contained in mitochondria of brown adipose tissue was measured when Wistar male rats were sniffed with juniper oil.

  Specifically, as in Test Example 2, randomly selected Wistar male rats (6 weeks old, weight 120-140 g) were divided into 2 groups (each group: 8 animals) The animals were allowed to naturally inhale the aroma emitted from juniper oil for 3 days (Juniper oil inhalation group), and the rats of group 2 were inhaled naturally for 3 days as a control (non-inhalation group). During the test, as in Test Example 2, the rats were allowed to freely consume food and water. Three days after inhalation, each group of rats was sacrificed by ether anesthesia, and the abdomen was opened to remove the brown adipose tissue between the shoulder ribs. Subsequently, mitochondria were extracted from the brown adipocytes, and the protein amount was measured using Bio-rad Protein Assay (Nippon Bio-Rad Laboratories).

  The results are shown in Table 3. In addition, each measured value of Table 3 is the average value +/- standard deviation of the measured value of each rat (8 animals) of each group.

  As shown in Table 3, it was confirmed that the amount of protein contained in mitochondria in the brown adipose tissue was significantly increased in the juniper oil inhalation group as compared to the non-inhalation group.

Test Example 4 Change in weight of white adipose tissue
The change in the weight of white adipose tissue was investigated when Wistar male rats were sniffed with juniper oil. Specifically, as in Test Example 2, randomly selected Wistar male rats (6 weeks old, body weight 125-145 g) were divided into 2 groups (each group: 6 animals), Scented from juniper oil was naturally inhaled for 8 days (Juniper oil inhalation group), and rats of group 2 were inhaled naturally for 8 days as a control (non-inhalation group). During the test, as in Test Example 2, the rats were allowed to freely consume food and water. On the 8th day after inhalation, the rats of each group were sacrificed by ether anesthesia, the abdomen was opened, the white adipose tissue around the testis was removed, and the weight was measured. The results are shown in Table 4. In addition, each measured value of Table 4 is the average value +/- standard deviation of the measured value of each rat (6 animals) of each group.

  As shown in Table 4, the weight of white adipose tissue was significantly reduced in the juniper oil inhalation group compared to the non-inhalation group. From the results of Test Example 2 above, it was suggested that the juniper oil inhalation group had an increase in brown adipose tissue, and that metabolism was promoted as the fat burning efficiency was improved. The results of this test showing that are considered to support this.

  That is, from the results of the above test examples, by sniffing juniper oil, brown adipose tissue increases, and as a result, fat burning is promoted, fat accumulation in the body is suppressed, or body fat decreases. It was suggested that an effect is obtained.

<Example>
A perfumed product containing the perfume composition of the present invention shown in the following formulation examples was prepared.
In addition, as the following juniper oil, an essential oil (trade name: juniper berry oil, Ogawa Fragrance Co., Ltd.) extracted from the berries of Juniperus communis (Cypressaceae) was used.

  Formulation Example 1: Liquid Air Freshener

  Formulation Example 2: Gel air freshener

  Formulation Example 3: Fragrance aerosol

  Formulation Example 4: Air freshener impregnated in unglazed

A mixture of juniper oil and isoparaffin was impregnated on a support (special calcium silicate (manufactured by Tokuyama, Fluorite RM-90)) and placed in an unglazed container.

  Formulation Example 5: Liquid air freshener for inhalation

  Formulation Example 6: Massage oil

  Formulation Example 7: Massage Cream

  Formulation Example 8: Acupuncture

  The above components were mixed at the above ratio and concentrated by heating. After molding, the bottle was cooled to prepare a bag.

  Formulation Example 9: Gum

  According to the fragrance composition and the scented product of the present invention, by increasing the brown adipose tissue in the body, or promoting the burning of body fat or promoting body fat metabolism, the accumulation of body fat can be suppressed, The amount of body fat can be reduced. Therefore, according to the present invention, it is possible to provide a fragrance composition and a scented product that can be effectively used to improve energy metabolism and make a constitution that is difficult to gain weight.

Claims (1)

A body fat burning accelerator consisting of or containing juniper oil .