WO2012108494A1

WO2012108494A1 - Deodorant containing polyvalent alcohol

Info

Publication number: WO2012108494A1
Application number: PCT/JP2012/052950
Authority: WO
Inventors: 巌龍口; 龍雄松岡
Original assignee: サントリーホールディングス株式会社
Priority date: 2011-02-10
Filing date: 2012-02-09
Publication date: 2012-08-16
Also published as: JPWO2012108494A1; CN103347545A; TWI554287B; CN103347545B; TW201235054A; JP5695678B2; HK1187285A1

Abstract

The problem addressed by the present invention is to provide a deodorant for deodorizing body odor, particularly the "old person smell" inherent to middle- and old-aged people, the deodorant being safe to use and having a strong deodorizing effect. By having the deodorant contain polyvalent alcohol, in particular 1,3-butylene glycol, as an active ingredient, it is possible to provide a deodorant with an outstanding deodorizing effect. The deodorant is particularly effective in deodorizing unsaturated aldehydes, which are the main cause of "old person smell".

Description

Deodorant containing polyhydric alcohol

The present invention relates to a deodorant. More specifically, the present invention is a deodorant containing a polyhydric alcohol, particularly 1,3-butylene glycol as an active ingredient, and has an excellent deodorizing effect on an unsaturated aldehyde that is a causative substance of an aging odor. The present invention provides an age-related odor inhibitor. The present invention also relates to a composition comprising 1,3-butylene glycol, oolong tea extract and strawberry tea extract.

In recent years, various deodorizers, deodorizers, and fragrances have been developed in response to the increasing values and needs of debaters seeking a more comfortable living space. In addition, the interest of the person responsible for body odor has increased, and the demand for a product having a deodorant effect has increased in recent years.

Among the body odors, it is known that the so-called “aged odor”, which is an odor mainly recognized by middle-aged and older people, is deeply related to unsaturated aldehydes such as octenal and nonenal. Specifically, 9-hexadecenoic acid (palmitoleic acid), which increases in sebum in middle-aged and elderly groups, is oxidized by and decomposed by lipid peroxides, or decomposed by resident skin bacteria. It is known to generate a certain onenal (Patent Document 1).

As a technique for removing the aging odor, a method of masking and harmonizing the generated unsaturated aldehyde with a fragrance (Patent Document 1) and a method of capturing with ethanolamine (Patent Document 2) have been reported. Moreover, the method of suppressing generation | occurrence | production of unsaturated aldehyde in sebum which causes generation | occurrence | production of an aging odor, and suppressing an aging odor is reported. Specifically, oxidation inhibition by an antioxidant (Patent Document 3), lipid peroxide production by a lipoxygenase inhibitor (Patent Document 4), growth inhibition by an antibacterial agent of skin resident bacteria involved in fatty acid production (Patent Document 4) Patent Document 5) reports a method for suppressing the generation of unsaturated aldehydes.

On the other hand, many cosmetics contain a polyhydric alcohol, and glycerin, propylene glycol, dipropylene glycol, and 1,3-butylene glycol are often used from the viewpoint of supply stability. Among these, 1,3-butylene glycol is known to be useful for cosmetic applications because it has non-volatile properties, low toxicity, and moisturizing properties. Specifically, it has been reported that it has a moisturizing action (Patent Document 6) and an antibacterial action / preservative action (Patent Document 7).

Japanese Patent Laid-Open No. 11-286428 JP 2001-97838 A Japanese Patent Laid-Open No. 11-286423 JP-A-11-286424 Japanese Patent Laid-Open No. 11-286425 JP-A-8-259433 (Patent No. 3159622) JP 2003-238328 A

An object of the present invention is to provide a deodorant or composition having a high deodorizing effect and high safety.

As a result of extensive research, the present inventors have found that polyhydric alcohols, particularly 1,3-butylene glycol, have a deodorizing effect. In particular, they have found that they have a significant deodorizing effect on unsaturated aldehydes, which are the causative substances of aging odors, and have completed the present invention.

That is, the present invention is not limited to this, but relates to the following.
(1) A deodorant containing a divalent or trivalent C2 to C6 alcohol as an active ingredient.
(2) The deodorizer according to (1), wherein the alcohol is 1,3-butylene glycol.
(3) The deodorizer according to (1) or (2), which is for deodorizing an aging odor.
(4) The deodorant according to any one of (1) to (3), wherein the odor component is an unsaturated aldehyde.
(5) The deodorizer according to (4), wherein the unsaturated aldehyde is nonenal or octenal.
(6) A deodorant composition comprising the deodorizer according to any one of (1) to (5).
(7) The deodorant composition according to (6), which is an external preparation for skin.
(8) A composition comprising 1,3-butylene glycol, oolong tea extract and strawberry tea extract.

The present invention provides a deodorant having an excellent deodorizing effect, which contains a polyhydric alcohol, particularly 1,3-butylene glycol as an active ingredient. Since the deodorizer of the present invention has an inhibitory effect on the causative substances of aging odors in particular, it can be blended in a deodorant composition for the purpose of suppressing deodorization. Especially, it can mix | blend with the composition for deodorizing aiming at age-related odor suppression. In another embodiment of the present invention, a composition having an excellent deodorizing effect can be provided by blending 1,3-butylene glycol, oolong tea extract and strawberry tea extract.

<Deodorant>
The deodorant of the present invention is characterized by containing a polyhydric alcohol, specifically, a divalent or trivalent C2-C6 alcohol as an active ingredient.

The deodorant of the present invention is intended for deodorization of various odor components, and in particular for the purpose of deodorizing an aging odor that is a body odor accompanying aging, in particular, an unsaturated aldehyde that is a causative substance of an aging odor It is provided as a deodorant for (Nonenal, Octenal, etc.).

Hereinafter, embodiments of the present invention will be described in detail.

Active ingredient of deodorant The active ingredient of the deodorant of the present invention is a polyhydric alcohol, specifically a divalent or trivalent C2-C6 alcohol. Examples of the divalent or trivalent C2 to C6 alcohol include glycerin, ethylene glycol, propylene glycol, 1,4-butanediol, diethylene glycol, dipropylene glycol, 1,3-butylene glycol, pentylene glycol, hexylene glycol and the like. Is mentioned. Among these, divalent C2 to C6 alcohols are preferable, and 1,3-butylene glycol is particularly preferable.

The amount of the active ingredient in the deodorant is not particularly limited, and may be 100% by weight of the active ingredient, but is 0.01 to 99% by weight, preferably 1 to 50% by weight, more preferably 5 to 30%. % By weight.

Deodorizing effect The deodorant of the present invention has an effect on various odors. For example, body odor (cough odor, foot odor, sweat odor, scalp odor, halitosis, etc.), pet odor, toilet odor, kitchen odor, refrigerator odor, fish or vegetable food odor, cigarette odor, clothing odor And the smell of shoes.

Accordingly, the deodorant of the present invention is, for example, a breath deodorant, a body odor deodorant, a pet deodorant, a livestock deodorant, a kitchen deodorant, a toilet deodorant, and a room deodorant. It can be used as a deodorant, a daily deodorant, an in-vehicle deodorant, an industrial deodorant, and the like.

Further, the deodorant of the present invention has an effect on an aging odor among body odors. The aging odor is not particularly limited as long as it is an odor contained in the aging odor, but is particularly effective against unsaturated aldehydes such as nonenal and octenal.

The deodorant of the present invention can be used by being held on a carrier. Examples of the carrier include gums such as agar, gelatin, carrageenan and gum arabic, gels such as polyvinyl alcohol and polyacrylamide, fibers such as various celluloses, porous materials such as zeolite, porous glass, ceramics, activated carbon, silica and silicate. Can be mentioned.

<Deodorizing composition>
The deodorant composition of the present invention can be prepared by blending the above deodorant.

The blending amount of the deodorant in the deodorant composition is not particularly limited, and may be 100% by weight of the active ingredient, but is 0.01 to 99% by weight, preferably 1 to 50% by weight, and more preferably. Is from 5 to 30% by weight.

The deodorizer of the present invention can be blended alone or in combination with other deodorant ingredients. There is no restriction | limiting in particular in the deodorizing component which can be used together, For example, a well-known masking agent, adsorption agent, a porous material, etc. are mentioned. In order to further enhance the effect of suppressing aging odor, it is possible to use a known deodorant for aging odor, for example, an antioxidant, a lipoxygenase inhibitor, an antibacterial agent, a masking harmony fragrance, ethanolamine, etc. it can. In addition, an extract or pulverized product of plant components such as oolong tea, strawberry tea, green tea, strawberry fruit, ogon, evening primrose and sugar cane can be added. Especially, the extract or ground material of oolong tea or strawberry tea which is excellent in the deodorizing effect to an aging odor can be used suitably.

As an aspect of the deodorant composition, it is preferably used as a skin external preparation. For example, facial cleansers, soaps, oral care products (mouth wash, toothpaste, etc.), shampoos, rinses, conditioners, hair creams, hair conditioners, hair tonics, hair growth / hair restorers, lotions, emulsions, creams , Etc.

In addition, the deodorant composition of the present invention can be blended with other components and additives within a range not impairing the effects of the present invention. These ingredients and additives include oils and fats such as vegetable oils, waxes such as lanolin and beeswax, hydrocarbons, fatty acids, higher alcohols, esters, various surfactants, moisturizers, whitening agents, pigments, Coloring agents, pigments, sweeteners, nutrition enhancers, fragrances, vitamins, amino acids, plant / animal extract components, UV absorbers, antioxidants, antiseptic / bactericides, and the like.

<Composition>
The composition in one embodiment of the present invention contains 1,3-butylene glycol, oolong tea extract and strawberry tea extract. In addition, the composition of the present invention may further contain a green tea extract and / or a strawberry fruit extract, or may contain other components. In particular, the composition is preferably used as a deodorant composition.

Preparation of oolong tea extract, strawberry tea extract, green tea extract and strawberry fruit extract can be performed by any method known to those skilled in the art. These extracts may be solid or liquid, and include pulverized products of leaves and fruits. In addition, the extraction step is not essential as long as the active ingredients derived from oolong tea, strawberry tea, green tea, and strawberry fruit are included.

The content of 1,3-butylene glycol in the composition of the present invention is not particularly limited, and is 0.01 to 99% by weight, preferably 1 to 70% by weight, and more preferably 5 to 60% by weight. Further, the total blending amount of the oolong tea extract and the strawberry tea extract in the composition, or the total blending amount of the whole extract obtained by further adding the green tea extract and / or the strawberry fruit extract to the composition is not particularly limited. Further, it is blended so that it is 0.0001 to 90% by weight, preferably 0.005 to 50% by weight, and more preferably 0.001 to 10% by weight in terms of dry weight.

The amount of each extract is not particularly limited. For example, two kinds of oolong tea extract and strawberry tea extract, or three or four extracts obtained by adding green tea extract and / or strawberry fruit extract to these extracts , The blending ratio of the extract in each combination is not particularly limited, but the dry weight of the other extract is 1 to 10 based on the dry weight of the smallest amount of the extract. Each can be blended so that the amount is double, preferably 1 to 5 times, more preferably 1 to 2 times.

The components contained in the oolong tea extract and strawberry tea extract blended in the composition of the present invention, or the components contained in the green tea extract and / or strawberry fruit extract that can be further blended are not particularly limited, but these extracts Examples of the main component include polyphenols. Polyphenol is a general term for compounds having a plurality of phenolic hydroxyl groups in one molecule, and is not particularly limited, but tannins, flavonoids, catechins extracted from tea leaves such as oolong tea, strawberry tea, and green tea, and strawberry fruits Etc.

The composition in one embodiment of the present invention is preferably used as a skin external preparation. For example, facial cleansers, soaps, oral care products (mouth wash, toothpaste, etc.), shampoos, rinses, conditioners, hair creams, hair conditioners, hair tonics, hair growth / hair restorers, lotions, emulsions, creams , Etc.

In addition, the composition which is an embodiment of the present invention can be blended with other components and additives within a range not impairing the effects of the present invention. These components and additives include extracts or pulverized products obtained from plant raw materials such as Japanese ogon, evening primrose, sugar cane, waxes such as lanolin and beeswax, hydrocarbons, fatty acids, higher alcohols, esters, various Surfactants, moisturizers, whitening agents, pigments, colorants, pigments, sweeteners, nutrient enhancers, fragrances, vitamins, amino acids, plant / animal extract ingredients, UV absorbers, antioxidants, antiseptics, antiseptics, etc. Is mentioned. Moreover, there is no restriction | limiting in particular in the deodorizing component which can be used together, For example, a well-known masking agent, adsorption agent, a porous material, etc. are mentioned. In addition, a deodorant for known aging odors such as an antioxidant, a lipoxygenase inhibitor, an antibacterial agent, a masking harmony fragrance, and ethanolamine can be used in combination.

Hereinafter, the present invention will be described in detail based on examples, but the present invention is not limited thereto.

[Example 1] Deodorant effect test 1 (sensory evaluation) for unsaturated aldehydes:
20 mL of 1% 1,3-butylene glycol aqueous solution was placed in each vial. 0.5 mL nonenal (trans-2-nonenal (first grade, Wako Pure Chemical Industries, Ltd.) diluted with olive squalane (NIKKOL refined olive squalane, manufactured by Nikko Chemicals)) 0.5 mL Added and quickly closed the rubber stopper. After leaving still at 40 degreeC conditions for 10 minutes, sensory evaluation was performed.

[result]
As shown in Table 1 below, it has been clarified that 1,3-butylene glycol has an excellent deodorizing effect on the nonenal odor as compared with the case where no addition is made.

[Example 2] Deodorizing effect test 2 for unsaturated aldehydes:
Using a 24% 1,3-butylene glycol aqueous solution, a deodorizing effect test for unsaturated aldehyde was conducted by the following method. Further, nonenal was used as the unsaturated aldehyde, and the reduction rate was analyzed and evaluated by high performance liquid chromatography.

<Test method>
・ Reagents and instruments Smell bag (25cm x 40cm) [Miyako Vinyl Processing Co., Ltd.]
Nonenal gas: A gas generated from trans-2-nonenal (first grade) [Wako Pure Chemical Industries, Ltd.] was used.
DNPH cartridge: GL-Pak mini AERO DNPH [GL Science Corporation]
-Evaluation sample As an evaluation sample, a 24% 1,3-butylene glycol aqueous solution and a control (water) were used.
-Operation After putting an evaluation sample and a control | contrast (water) in an odor bag and heat-sealing, 4L of air was enclosed, and the nonenal gas was added so that it might become the set gas concentration. This was left to stand, and 300 mL of gas in the bag was collected in a DNPH cartridge every elapsed time (after 0, 30, 60, 180 minutes). The DNPH derivative was eluted through 5 mL of acetonitrile on the DNPH cartridge that collected the gas, and the eluate was measured by high performance liquid chromatography to calculate the gas concentration in the bag. The operating conditions of the high performance liquid chromatograph are shown below.
・ High-performance liquid chromatograph operating conditions Model: LC-2010AHT [Shimadzu Corporation]
Detector: UV absorption detector Column: RP-Amide, φ4.6 mm × 25 cm [Sigma Aldrich Japan Co., Ltd.]
Column temperature: 40 ° C
Mobile phase: A mixture of acetonitrile and water (acetonitrile: water = 80: 20)
Mobile phase flow rate: 1.5 mL / min
Measurement wavelength: 360 nm
Injection volume: 40 μL
Test conditions Amount of specimen used: 5 mL of evaluation sample (24% 1,3-butylene glycol aqueous solution), 5 mL of control (water)
Test target gas: Nonenal (initial gas concentration: 22 ppm)
Temperature condition: room temperature

<Result>
As shown in Table 2 below, it was revealed that the 24% 1,3-butylene glycol aqueous solution had a large reduction rate of unsaturated aldehyde compared with the control and had an excellent deodorizing effect.

[Example 3] Deodorizing effect test 3 for unsaturated aldehydes:
Using 100% 1,3-butylene glycol, the deodorizing effect test for unsaturated aldehyde was conducted by the following method. Further, nonenal was used as the unsaturated aldehyde, and the reduction rate was evaluated by analyzing it under the same conditions as in Example 2 by high performance liquid chromatography.

<Test method>
Example 2 and Example 2 except that 100% 1,3-butylene glycol (5 mL) and water (5 mL) as a control were used as an evaluation sample, and that the initial gas concentration of Nonenal as a test target gas was 18 ppm. A deodorization evaluation test was conducted in the same manner.

<Result>
As shown in Table 3 below, 100% 1,3-butylene glycol has a greater reduction rate of unsaturated aldehydes than the 24% 1,3-butylene glycol aqueous solution of Example 2, and has a remarkable deodorizing effect. Had.

[Example 4] Deodorizing effect test 4 for unsaturated aldehydes:
<Test method>
-Evaluation sample As the oolong tea extract, a commercially available cosmetic raw material (oolong tea extract BG (manufactured by Maruzen Pharmaceutical Co., Ltd.): 50% 1,3-butylene glycol solution) containing oolong tea extract as a main component was used. In addition, a commercially available cosmetic raw material (meal tea extract BGW (manufactured by Maruzen Pharmaceutical Co., Ltd.): 50% 1,3-butylene glycol solution) mainly composed of tea tea extract was used as the tea tea extract. Furthermore, as a green tea extract, a commercially available cosmetic raw material (Japanese ism green tea (manufactured by Maruzen Pharmaceutical Co., Ltd .: 50% 1,3-butylene glycol solution)) containing a green tea extract as a main component is used. A commercially available cosmetic raw material (Pancil BA-210-1, manufactured by Release Science Industry Co., Ltd.) mainly composed of persimmon fruit extract was used.

The above oolong tea extract (2.5 mL) and strawberry tea extract (2.5 mL) are such that the extract (containing polyphenol as a main component) is 1% by weight, and the amount of each extract is equal. Thus, an evaluation sample (5 mL) of 1,3-butylene glycol + two kinds of mixed extracts was prepared. The content of 1,3-butylene glycol was (50% by weight). Similarly, the above oolong tea extract, strawberry tea extract and green tea extract were blended so that the extract content was 1% by weight and the amount of each extract was equal, and 1,3-butylene was added. An evaluation sample of glycol + three-type mixed extract (1) was prepared. Further, the above oolong tea extract, strawberry tea extract and strawberry fruit extract were blended so that the extract content was 1% by weight and the amount of each extract was equal, and 1,3-butylene was added. An evaluation sample of glycol + 3 species extract (2) was prepared. Further, the above oolong tea extract, strawberry tea extract, green tea extract and strawberry fruit extract are blended so that the extract content is 1% by weight and the amount of each extract is equal. , 3-Butylene glycol + 4 kinds of mixed extract evaluation samples were prepared.

・ Operation In the same manner as in Example 2, except that the above-mentioned mixed extract containing 1,3-butylene glycol was used as an evaluation sample and water (5 mL) was used as a control, mixed extraction of 1,3-butylene glycol and two kinds was performed in the same manner as in Example 2 above. And 1,3-butylene glycol + 4 species mixed extract, and 1,3-butylene glycol + 3 species mixed extract (1) and 1,3-butylene glycol + 3 species mixed extract (2) A deodorizing effect test for saturated aldehyde was conducted separately. Moreover, nonenal was used as an unsaturated aldehyde, and the reduction rate was evaluated by analyzing it under the same conditions as in Example 2 by high performance liquid chromatography. Note that the initial gas concentrations of Nonenal, which is the test target gas, were 20 ppm (when the above-mentioned two kinds and four kinds of samples were evaluated) and 20 ppm (when the above three kinds of samples were evaluated), respectively.

<Result>
As shown in the following table, all of the above 1,3-butylene glycol + two-type mixed extract, three-type mixed extract (1) and (2), and four-type mixed extract were not compared with the control. It was revealed that the reduction rate of saturated aldehyde was large and the deodorizing effect was excellent.

[Production Example 1] Soap A production example of a deodorant composition containing 1,3-butylene glycol is shown below.

Table 5 shows the blending amount of raw materials. The soap base was mixed and stirred, and then 1,3-butylene glycol and each extract were added, mixed uniformly, and molded.

[Production Example 2] Shampoo Table 6 shows the blending amounts of raw materials.

Preservative dissolved in 1,3-butylene glycol was added to purified water. After stirring uniformly, sodium laureth sulfate and coconut oil fatty acid monoethanolamide were added, and then a dye, a fragrance and the remaining 1,3-butylene glycol were added, and then mixed and stirred uniformly.

[Production Example 3] Conditioner Table 7 shows the blending amount of raw materials.
(1) Stearyldimethylbenzylammonium chloride and sodium chloride were added to purified water and heated to 80 ° C. to dissolve.
(2) Cetostearyl alcohol and glycerol monostearate were heated to 80 ° C. and dissolved.
(3) While stirring (1) with a homomixer, add (2), and after the addition, pre-stir for 5 minutes,
(4) After completion of preliminary stirring, the mixture was cooled to 50 ° C. with stirring, 1,3-butylene glycol was added, and the mixture was further cooled to 35 ° C. with stirring.

[Production Example 4] Hair tonic Table 8 shows the blending amounts of raw materials.

Vitamin E and L-menthol dissolved in salicylic acid and ethanol were added to purified water, glycyrrhizin dissolved in a portion of purified water was added, and then 1,3-butylene glycol was added and mixed uniformly. .

[Production Example 5] Table 9 shows amounts of mist raw materials.

Into purified water, citric acid and sodium citrate were added and dissolved. Thereafter, a preservative and polysorbate 80 dissolved in ethanol were added. Thereafter, 1,3-butylene glycol was added thereto and stirred uniformly.

[Production Example 6] Toner lotion Table 10 shows the blending amounts of raw materials.

Into purified water, citric acid and sodium citrate were added and dissolved. Next, glycerin, 1,3-butylene glycol and trisodium ethylenediaminetetraacetate were sequentially added, and polyoxyethylene (18) oleyl alcohol ether and vitamin E dissolved in ethanol were further added and stirred until uniform.

[Production Example 7] Emulsion Table 11 shows blending amounts of raw materials.
(1) Stearic acid, cetyl alcohol, octyldodecyl myristate and liquid paraffin were heated to 80 ° C. and dissolved.
(2) Triethanolamine, sodium hyaluronate, glycerin, 1,3-butylene glycol and sodium ethylenediaminehydroxytriacetate were added to purified water and heated to 80 ° C.
(3) While stirring (1) with a homomixer, (2) was added and pre-stirred for 5 minutes after charging.
(4) After completion of preliminary stirring, the mixture was cooled to 50 ° C and further cooled to 35 ° C.

[Production Example 8] Table 12 shows the amounts of the cream raw materials.
(1) Stearic acid, glyceryl monostearate, sorbitan sesquistearate, polyoxyethylene sorbitan monostearate, cetostearyl alcohol, liquid paraffin, hexa (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, tri-2-ethylhexane Glyceryl acid and dimethicone were heated to 80 ° C. and dissolved.
(2) Glycerin, 1,3-butylene glycol, sodium hydroxide and methylparaben were added to purified water and heated to 80 ° C. to dissolve.
(3) While stirring (1) with a homomixer, (2) was added and pre-stirred for 5 minutes after charging.
(4) After completion of preliminary stirring, the mixture was cooled to 50 ° C and further cooled to 35 ° C.

Claims

Deodorant containing divalent or trivalent C2 to C6 alcohol as an active ingredient.
The deodorant according to claim 1, wherein the alcohol is 1,3-butylene glycol.
The deodorizer according to claim 1 or 2, which is used for deodorizing an aging odor.
The deodorant according to any one of claims 1 to 3, wherein the odor component is an unsaturated aldehyde.
The deodorizer according to claim 4, wherein the unsaturated aldehyde is nonenal or octenal.
A deodorant composition comprising the deodorizer according to any one of claims 1 to 5.
Deodorant composition according to claim 6, which is an external preparation for skin.
A composition comprising 1,3-butylene glycol, oolong tea extract and strawberry tea extract.