KR20220067218A - Composition for enhancing attention and concentration comprising extract of zanthoxylum piperitum - Google Patents

Abstract

The present invention relates to a composition for enhancing attention and concentration comprising a Zanthoxylum piperitum extract as an active ingredient, wherein the composition includes Zanthoxylum piperitum essential oil and Zanthoxylum piperitum distillate, thereby exhibiting an excellent attention and concentration improving effect and thus being used for various purposes.

Description

A composition for enhancing concentration comprising a bark extract as an active ingredient

The present invention relates to a composition for enhancing attention and concentration comprising a bark extract as an active ingredient.

The most central thing in humans is brain function, and when brain cells are active, attention and concentration increase.

As people age, the brain function decreases, and accordingly, attention and concentration are weakened. This low concentration of attention causes psychological anxiety, which not only causes various diseases, but also causes difficulties in daily life.

Recently, as well-being and LOHAS (lifestyles of health and sustainability, LOHAS) emerged as a trend, as a way to improve this concentration of attention, research on fragrance (aroma) therapy using fragrances derived from natural products and consumers’ Interest is also on the rise.

Aroma (aroma) therapy refers to natural or alternative therapy using fragrances extracted from plants with fragrance.

Specifically, in aroma therapy, perfume stimulates the cerebral limbic system through the sense of smell, and the cerebral limbic system affects the autonomic nervous system and endocrine system through the hypothalamus to activate brain functions.

In addition, fragrances, which are plant extracts, often have activities related to healing of physical diseases such as antibacterial, antiseptic, and analgesic in addition to fragrance (smell), so that pharmacological effects can also be obtained. In addition, as the fragrance is extracted from plants such as herbs or medicinal herbs, there is no side effect on the human body and it has the advantage that it can be utilized for various purposes.

Accordingly, although research on natural plant-derived fragrances having an effect of enhancing concentration is continuously made (see Patent Documents 1 to 3), the effect is not sufficient.

On the other hand, the bark ( Zanthoxylum piperitum ) is a deciduous shrub of the rutaceae family, and the fruit bark (fruit peel) is usually used as a spice and medicine, and seeds, leaves, and stems are also used for various purposes. Chopi fruit is used in oriental medicine as detoxifying, anthelmintic, and analgesic, and is mainly distributed in Korea, Japan, and China.

In the case of the prior art, the bark extract, mainly the bark extract, is limited to exhibiting effective activity in antibacterial, antiviral, insecticidal, anticancer, anti-inflammatory, arteriosclerosis, hyperlipidemia, diabetes, osteoporosis, and skin whitening, and improvement of concentration of the bark extract There is a lack of research on efficacy and efficacy.

Republic of Korea Patent Publication No. 2018-0041388 (April 24, 2018), Grape flavoring composition containing essential oil of Schisandra asiatica for improving concentration and use thereof Republic of Korea Patent Publication No. 2019-0119824 (2019.10.23), a perfume composition that reduces relative theta waves and increases relative alpha waves in brain waves containing essential oil of Chrysanthemum flower as an active ingredient, and uses thereof Republic of Korea Patent Registration No. 10-2152076 (Aug. 31, 2020), Fragrance composition for improving concentration and manufacturing method thereof

Accordingly, the present inventors completed the present invention by confirming that as a result of conducting multifaceted research to solve the above problem, the bark distillate and bark essential oil extracted from the bark showed the effect of enhancing concentration independently of psychological stability.

Accordingly, it is an object of the present invention to provide a composition for improving concentration comprising a bark extract, specifically, a bark distillate and essential oil of bark bark, capable of enhancing concentration independently of emotional stability.

Another object of the present invention is to provide a cosmetic composition comprising the composition.

Another object of the present invention is to provide a perfume composition comprising the composition.

Another object of the present invention is to provide a perfume composition comprising the composition.

Another object of the present invention is to provide a quasi-drug composition comprising the composition.

In order to achieve the above object, the present invention provides a composition for enhancing concentration comprising a distillate of bark skin and essential oil of bark skin as active ingredients.

In one embodiment of the present invention, the skin distillate is included in an amount of 33.3 to 99.9% by weight based on 100% by weight of the composition for enhancing concentration.

The herbal essential oil is included in an amount of 0.01 to 0.1% by weight based on 100% by weight of the composition for improving concentration.

In one embodiment of the present invention, the bark distillate and the bark essential oil are bark extracts obtained by extracting the bark by steam distillation.

In one embodiment of the present invention, the bark distillate is an aqueous layer component of the bark extract.

In one embodiment of the present invention, the bark essential oil is an oily component of the bark extract.

In addition, the present invention provides a cosmetic composition comprising the composition.

In one embodiment of the present invention, the cosmetic composition has an antibacterial effect.

In one embodiment of the present invention, the cosmetic composition has a skin soothing effect.

In addition, the present invention provides a perfume composition comprising the composition.

In addition, the present invention provides a perfume composition comprising the composition.

In addition, the present invention provides a quasi-drug composition comprising the composition.

The composition according to the present invention is effective in enhancing concentration by enabling positive brain activity apart from psychological and emotional stability by including essential bark oil and bark distillate. In addition, the composition according to the present invention can be highly added by increasing the utilization value of the bark extract by utilizing the bark distillate, which is conventionally considered a by-product, and can improve the productivity of the bark extract.

1 is a graph showing the skin soothing efficacy evaluation results of the epidermal distillate according to Experimental Example 3 of the present invention.
2 is a graph showing the panel evaluation results for the degree of attention improvement according to Experimental Example 4 of the present invention.
3 is a graph showing the panel evaluation results for the fragrance preference of the composition according to Experimental Example 6 of the present invention.
4 is a graph showing the panel evaluation results for the concentration improvement degree of the composition according to Experimental Example 6 of the present invention.
5 is a graph showing a change in the concentration index of the composition according to Experimental Example 7 of the present invention.
6 is a graph showing a change in the attention index of the third panel according to Experimental Example 7 of the present invention.
7 is a graph showing changes in the attention index of panel 4 according to Experimental Example 7 of the present invention.

Hereinafter, the present invention will be described in more detail.

The terms or words used in the present specification and claims should not be construed as being limited to their ordinary or dictionary meanings, and the inventor may properly define the concept of the term in order to best describe his invention. Based on the principle that there is, it should be interpreted as meaning and concept consistent with the technical idea of the present invention.

The terms used in the present invention are only used to describe specific embodiments, and are not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly dictates otherwise. In the present invention, terms such as 'comprising' or 'having' are intended to designate that the features, numbers, steps, operations, components, parts, or combinations thereof described in the specification exist, and one or more other features It is to be understood that this does not preclude the possibility of addition or existence of numbers, steps, operations, components, parts, or combinations thereof.

Aroma therapy uses natural fragrances extracted from aromatic plants such as herbs and medicinal herbs, and has the effect of promoting and maintaining human physical, mental and psychological health, and enhancing vitality.

Natural fragrances are particularly popular because they have few side effects and can be easily used by anyone. For modern people who have to spend most of their time indoors, the development of products using natural fragrances is expanding as a way to improve work efficiency.

Accordingly, in the present invention, it is newly confirmed that the bark extract, which has been mainly used as a conventional spice and medicine, exerts an effect of improving concentration, and thus provides a composition for enhancing concentration including the extract of bark extract.

Specifically, the composition for enhancing concentration according to the present invention is characterized in that it contains a bark distillate and an essential oil of bark skin as active ingredients.

In particular, the composition comprising the bark distillate and the bark essential oil according to the present invention has the effect of enhancing the concentration of attention by enabling positive brain activity independent of psychological and emotional stability while emitting the original scent of the bark bark.

In the present invention, the bark distillate (also called bark water) and bark oil essential oil (also called bark (essential) oil) are bark extracts obtained from all parts of the bark, such as leaves, stems, flowers, fruits, seeds, roots, and bark. means, and the extraction site is not limited to a specific part. In the present invention, the term "essential oil of the bark of the bark" includes natural vegetable oil that can be extracted from the bark, and means that it corresponds to the oil layer among the extracts from the bark of the bark obtained by a conventional distillation extraction method. In the present invention, the term "distillate from bark" corresponds to the aqueous layer of the bark extract obtained by a conventional distillation extraction method, and may include some components having water solubility among the components included in the essential oil for bark.

The bark distillate and bark essential oil can be prepared from bark using a conventional extraction method for obtaining an extract from a plant.

In the present invention, the bark distillate and essential oil may be obtained by extracting the bark of the bark by steam distillation. In the steam distillation method, since the extraction target is extracted only with steam without direct contact with the extraction solvent, it is possible to efficiently extract the essential oil of the bark of an oil. In addition, since the steam distillation method does not use an extraction solvent, it does not require a removal process, so it is eco-friendly, and has the advantage of being able to obtain a bark distillate and skin peel essential oil with high stability, as well as easy utilization thereof.

Specifically, the steam distillation method can extract the bark extract containing the bark distillate and the bark essential oil by breaking the cell wall of the plant using water vapor.

As an example, the bark is put into an extractor and extracted by steam distillation. At this time, all the bark extracts obtained are collected and cooled at a low temperature. When separated, the aqueous and oil layers are separated. The skin distillate of the present invention can be obtained from the aqueous layer. In addition, the essential oil of the present invention can be obtained from the oil layer.

In the case of the prior art, only the oil layer, bark essential oil, was used, and the aqueous layer, bark distillate, was discarded as a by-product. On the other hand, in the case of the present invention, since the bark distillate, which is a conventionally discarded aqueous layer component, is used as an active ingredient, it can be highly added by increasing the utilization value of the bark extract, and there is an advantage that can improve the productivity of the bark extract.

The extraction target of the bark distillate and bark essential oil is derived from all parts of the bark as described above and can be used for extraction without limitation in its composition, but in terms of functional effect or content of essential oil of the bark ) is preferably used.

The bark used for the extraction may be used as it is or dried after it is collected. As the drying method, both drying in the sun, shade drying, hot air drying, and natural drying may be used. In addition, in order to increase the extraction efficiency, the bark or its dried product may be pulverized or pre-treated with a pulverizer.

The extraction time may vary depending on the dry state of the cuticle, for example, may be 1 hour to 10 hours.

The bark distillate and bark skin essential oil obtained as described above contain various components. Specifically, the bark distillate contains one or more selected from the group consisting of 1,8-cineol, methyl cinnamate, and citral as a main component And, the bark essential oil contains at least one selected from the group consisting of phellandrene, citronellal, and d-limonene as a main component.

The skin distillate may be included in an amount of 33.3 to 99.9% by weight based on 100% by weight of the composition for enhancing concentration. Specifically, the content of the skin distillate may be 35% by weight, 40% by weight, 50% by weight, 60% by weight, 70% by weight, or 80% by weight with respect to 100% by weight of the composition for improving concentration, and , the upper limit may be 98 wt%, 97 wt%, 96 wt%, or 95 wt%. The content of the skin distillate may be set as a combination of the lower limit and the upper limit. When the content of the skin distillate is out of the above range, there may be a problem in that the skin soothing effect and the antibacterial effect are lowered as well as the attention improving effect of the skin distillate.

The herbal essential oil may be included in an amount of 0.01 to 0.1% by weight based on 100% by weight of the composition for improving concentration. Specifically, the content of the essential bark oil may be 0.015% by weight, 0.02% by weight, 0.025% by weight, 0.03% by weight, or 0.04% by weight, and the upper limit is 0.09% by weight based on 100% by weight of the composition for improving concentration %, 0.08 wt%, 0.07 wt%, 0.06 wt%, or 0.05 wt%. When the content of the essential bark oil is less than the above range, the characteristic odor of the essential oil is weak. On the contrary, when the content of the essential oil is over the above range, the stability of the composition is lowered, and the characteristic odor of the essential oil is too strong. There is a problem of lowering.

As described above, the composition for enhancing the concentration of the present invention, comprising the bark distillate and bark essential oil as active ingredients, is a solvent, surfactant, antioxidant, preservative, It may further include known additives such as a chelating agent, a UV absorber, and a pigment.

The composition for enhancing attention according to the present invention exhibits a function of improving concentration, and the present invention provides a use in which the composition for enhancing attention is used in a cosmetic composition, a perfume composition, a perfume composition, or a quasi-drug composition.

When applied as a cosmetic composition, the composition for enhancing concentration according to the present invention is used in an amount of 50 to 100% by weight, preferably 70 to 90% by weight, based on 100% by weight of the cosmetic composition. If the content of the composition for improving concentration is less than the above range, the effect of improving concentration is insignificant due to very low scent diffusing property.

In addition, the Chopi water included in the composition for enhancing concentration according to the present invention exhibits a skin soothing effect and an antibacterial effect that inhibits the activity of Acne, Candida, and the like. The cosmetic composition exhibits skin soothing and antibacterial effects in addition to the above-mentioned concentration enhancing effect.

The cosmetic composition of the present invention may be prepared in any formulation conventionally prepared in the art. For example, it can be formulated into solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, oils, foundations, and sprays. Specifically, it can be used as skin care, pack/mask, makeup, cleansing, sun care, body, and hair products. More specifically, softening lotion, astringent lotion, nourishing lotion, facial mist, nourishing lotion, nourishing essence, nourishing cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, gel, Patch, mask, powder, makeup base, foundation, mascara, lipstick, sun cream, sun balm, body cleanser, body lotion, body cream, body oil, body essence, body mist, body scrub, deodorant, shampoo, conditioner, conditioner, It may be manufactured into products such as hair treatment, hair wax, hair mist, hair essence, and hair oil.

For example, when the cosmetic composition is prepared as a facial mist, it has an antibacterial effect against acne bacteria and a skin soothing effect as well as an effect of enhancing concentration.

In addition, the cosmetic composition may be formulated including an acceptable carrier, medium or base in the field of cosmetics. further fatty substances, organic solvents, solubilizers, thickening and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, adjuvants commonly used in the field of cosmetology, such as chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic actives, lipophilic actives, lipid vesicles or any other ingredient commonly used in cosmetics; may contain. In addition, the above ingredients may be introduced in an amount generally used in the cosmetic field.

When applied as a perfume composition, the composition for enhancing concentration according to the present invention is used in an amount of 50 to 100% by weight, preferably 70 to 90% by weight, based on 100% by weight of the perfume composition. If the content of the composition for improving concentration is less than the above range, the scent diffusing property is very low, and the effect of improving concentration may be insignificant.

The perfume composition may be perfume or scented fragrance, and may further include additives commonly used in the art.

When applied as a perfume composition, the composition for enhancing concentration according to the present invention is used in an amount of 50 to 100% by weight, preferably 70 to 90% by weight, based on 100% by weight of the perfume composition. If the content of the composition for improving concentration is less than the above range, the scent diffusing property is very low, and the effect of improving concentration may be insignificant.

The perfume composition may be prepared in any formulation conventionally prepared in the art, for example, it may be prepared in a gel formulation, a solid phase, or a liquid phase. For this use, additives such as flavoring agents, perfumes, and excipients used in known perfumes may be further included.

When applied as a quasi-drug composition, the composition for enhancing concentration according to the present invention is used in an amount of 50 to 100% by weight, preferably 70 to 90% by weight, based on 100% by weight of the quasi-drug composition. If the content of the composition for enhancing attention is less than the above range, the antibacterial effect is lowered and the scent diffusing property is very low, so the effect of improving concentration may be insignificant.

In addition, since the composition for enhancing concentration according to the present invention has antibacterial activity against Acne and Candida along with the effect of improving concentration, the quasi-drug composition includes the composition for enhancing concentration of the present invention as described above. It shows the antibacterial effect as well as the attention-enhancing effect.

The quasi-drug composition may be prepared in any formulation conventionally prepared in the art, for example, disinfectant cleaner, cleaner, dishware cleaner, toothpaste, mouthwash, wet tissue, detergent soap, hand wash, humidifier cleaner, mask , ointment, filter cleaner, etc. can be prepared. For this use, additives such as flavoring agents, fragrances, and excipients used in known quasi-drugs may be further included.

Hereinafter, preferred examples are presented to help the understanding of the present invention, but the following examples are merely illustrative of the present invention, and it will be apparent to those skilled in the art that various changes and modifications are possible within the scope and spirit of the present invention, It goes without saying that such variations and modifications fall within the scope of the appended claims.

Example and comparative example

The bark extract was prepared using steam distillation method from the bark purchased from a vegetable grower in Gurye, Jeollanam-do.

Specifically, the peel and seeds of 800 g of bark fruit dried for about a day after collection are separated, and 200 g of bark peel is distilled with steam at 100 ° C for 4 hours, and the resulting vapor is cooled at low temperature, separated and purified, and 5 g of essential oil 400 g of pericarp distillate was prepared.

A cosmetic composition including a composition for enhancing concentration was prepared by adding and mixing the ingredients of Table 1 below according to the content in a stirrer.

Ingredients (unit: wt%) Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Butylene Glycol 3 3 3 3 - - PPG-13-decyltetradeceth-24 0.3 0.3 0.3 0.3 - - Caprylic/Capric Triglycerides 0.2 0.2 0.2 0.2 - - Disodium-EDTA 0.02 0.02 0.02 0.02 - - Chopi essential oil prepared in (1) above 0.01 0.03 0.05 0.07 0.05 - The skin distillate prepared in (1) above balance balance balance balance - 100 Purified water - - - - balance -

Experimental example One. Chopi essential oil and Chopi Component analysis of distillates

Analysis of the components of the bark extract and the bark distillate prepared in Examples was commissioned by Hanbit Perfume Co., Ltd. A gas chromatography/mass spectrometer (7890A GC/5975C MS, Agilent, USA) was used, and a DB-FFAP (60 mХ0.25 mm×0.5 μm) was used for the GC/MS column, and a carrier gas ( carrier gas) was analyzed by using He to flow at 1.2 ml/min. The temperature of the oven was maintained at 50 ℃ (fixed for 5 minutes)-2 ℃ min-220 ℃ (50 minutes), and the temperature of injection was analyzed at 240 ℃. In addition, the temperature of the interface was analyzed at 240 ℃, the temperature of the ion source at 230 ℃, and the temperature of the analyzer at 150 ℃, and the mass range was analyzed at 30~350 m/z.

Identification of the constituents of bark essential oil and bark distillate is consistent with retention indices (RI) and retention times of standard substances or by comparing the mass spectrum of volatile substances with the mass spectrum of Wiley 11 Nist 17 library. was confirmed. In addition, in the case of skin distillate, only volatile components except for water were analyzed. The RI was determined using C6 ~ C24 (n-alkane) under the same conditions as the sample. The results obtained at this time are shown in Table 2, and in Table 2, only the contents of the main components are described.

Ingredients (unit: wt%) Chopi essential oil bark distillate pellandren 35.78 5.33 Citronellal 24 0.38 D-limonene 14.76 0.63 1,8-Cineole <0.1 17.9 methyl cinnamate 0.06 15.11 citral <0.47 <15

As shown in Table 2 above, the bark essential oil contains phellandrene, citronellal, and D-limonene as major components, whereas the bark distillate contains 1,8-cineol, methyl cinnamate, and citral. It can be confirmed that it is included as a main ingredient.

Experimental example 2. Chopi essential oil and Chopi Evaluation of antibacterial efficacy of distillates

A minimum inhibitory concentration test was performed on microorganisms to confirm the antibacterial efficacy of the bark essential oil and bark distillate prepared in Examples.

In order to confirm the antimicrobial activity of the bark extract obtained from the examples and the bark distillate through the minimum inhibitory concentration test, the following experiments were carried out. C. albicans was cultured in a general chamber at 25 °C using SD medium, and C. acnes was cultured in an anaerobic chamber at 35 °C using BHI medium. The C. albicans culture medium was diluted 1/100 in the medium, and the C. acnes culture medium was diluted to 1/10 concentration in the medium, and each dilution was used as a test bacterial solution. Using a 5% DMSO solution of 0.471 ml of each medium and 0.25 ml of DMSO as a solvent, 0.04 ml of essential oil was added to dilute, and the distillate was used without dilution.

Each of two 96-well plates (well plate), each of the diluted C. albicans culture solution and C. acnes is put into the 1st row, and 0.2 ml each of diluted C. albicans and C. acnes is added to the remaining wells. 0.1 ml of each culture medium was added. After mixing the mixed solution in row 1 well, take 0.1 ml, put it in row 2, mix well, then take 0.1 ml again and put it in row 3, followed by double dilution. C. albicans is cultured in an incubator at 25 ° C for 48 hours and C. acnes is incubated in an anaerobic chamber at 35 ° C for 72 hours, respectively, and the minimum concentration without growth is determined by judging whether or not the bacteria have grown by suspension . and for each of C. acnes It was determined as the minimum inhibition concentration (MIC). If it is difficult to determine whether or not the growth of bacteria is by suspension, it was confirmed through microscopic observation. The results obtained at this time are shown in Table 3.

strain Minimum inhibitory concentration (unit: %) Chopi essential oil bark distillate C. albicans 0.05 100 C. acnes 0.05 100

As shown in Table 3 above, Chopi essential oil exhibited excellent antibacterial action against Acne and Candida.

Specifically, it can be seen that the bark essential oil exhibits antibacterial efficacy at a significantly lower concentration than that of the bark distillate.

Experimental example 3. Chopi Evaluation of the skin soothing effect of the distillate

TRPM8 (transient receptor potential melastatin 8) Activity Assay was performed to confirm the skin soothing effect of the epidermal distillate prepared in Example. The TRPM8 Activity Assay is a method for evaluating agonists having the effect of activating TRPM8, a cold receptor in cells.

CHO-K1 (TRPM8) cells overexpressing TRMP8 were seeded in a 96-well plate at a concentration of 5*10 ⁴ cells/well, and then cultured in a cell incubator (37° C., 5% CO ₂ incubator) for 24 hours. At this time, a cell culture medium containing RPMI-1640 (w/ 20mM HEPES), 10% FBS, and 1% Antibiotics was used. After incubation for 24 hours, each well was washed with HBSS, and cells were treated with 100 μl of dye solution of Fluo-4NW calcium assay kits (Thermo Fisher Scientific, Cat. F36206) and reacted for 30 minutes in a cell incubator.

After the reaction was completed, 50 μl of the sample was dispensed onto the cell plate in the Flexstation3 device, a high-speed kinetic calcium measurement device. At this time, the sample was prepared by diluting the epidermal distillate for each concentration in 0.5% DMSO solution. The fluorescence value (Excitation 494 nm / Emission 516 nm) was measured for 1 minute immediately after the sample was dispensed into the cells in the device. Through this measurement, the increase in intracellular calcium ion concentration was quantified as the TRPM8 activity value. At this time, Ionomycin, a calcium ion transporter, and menthol, which is known to have an excellent cooling effect as an agonist of TRPM8, were used as positive controls. The results obtained at this time are shown in FIG. 1 .

As shown in Figure 1 below, it can be seen that the bark distillate exhibits excellent skin soothing effect.

Experimental example 4. Chopi Panel evaluation of the improvement in concentration of essential oils

An evaluation of the improvement in attention concentration of other essential oils (essential oils) including the pure herbal extracts prepared in Examples was conducted for 8 members of a panel specializing in fragrance. In addition, in order to evaluate the change in the degree of improvement in attention and concentration over time, each essential oil was applied to the skin and immediately after smelling the scent and after 30 seconds, respectively, were evaluated. The degree of improvement in attention concentration was evaluated on the basis of a full scale of 10, and the results obtained at this time are shown in FIG. 2 and Table 4.

Chopi lemon lavender eucalyptus patchouli immediately after after 30 seconds immediately after after 30 seconds immediately after after 30 seconds immediately after after 30 seconds immediately after after 30 seconds panel 1 8 7 8 4 5 4 8 5 3 3 panel 2 7 6 7 3 4 3 7 4 2 2 panel 3 7 7 8 4 4 4 9 5 3 2 panel 4 8 6 8 5 5 3 7 5 3 2 panel 5 9 6 8 4 6 4 9 7 3 3 panel 6 7 5 7 2 3 3 8 5 3 2 panel 7 8 6 9 4 5 4 7 4 2 One panel 8 7 6 7 3 4 3 8 5 3 2 medium 7.63 6.13 7.75 3.63 4.50 3.50 7.88 5.00 2.75 2.13

2 and Table 4 below, the attention improvement effect immediately after smelling the scent was shown in the order of eucalyptus, lemon, chopi, lavender, and patchouli. can However, it can be seen that the attention improvement effect after 30 seconds is different from the initial result in the order of Chopi, eucalyptus, lemon, lavender, and patchouli.

In the case of lavender and patchouli, which give a comfortable feeling of smell, both immediately after smelling the scent and after 30 seconds, the effect of improving attention was low. It can be seen that the effect of improving concentration is reduced after 30 seconds due to its light weight and low persistence. On the other hand, in the case of chopi, the scent persistence is superior to that of other essential oils, so it can be seen that the effect of improving concentration immediately after inhaling the scent and after 30 seconds is high.

Experimental example 5. Incense Panel Rating for Preference

The fragrance preference for the cosmetic compositions prepared in Examples and Comparative Examples was evaluated by eight panelists specializing in fragrance according to the following average criteria. The results obtained at this time are shown in Table 5.

<Evaluation criteria>

Very bad: 0-2 points

Bad: 3-4 points

Normal: 5-6 points

Good: 7-8 points

Very good: 9-10 points

Example 1 Example 2 Example 3 Example 4 panel 1 4 5 7 5 panel 2 3 7 8 6 panel 3 5 6 6 5 panel 4 5 7 7 4 panel 5 6 5 6 4 panel 6 6 8 7 6 panel 7 5 6 8 6 panel 8 6 6 8 6 medium 5 6.25 7.125 5.25

As shown in Table 5, although the fragrance preference of the cosmetic composition according to the embodiment is above average (5 to 6 points), it can be seen that the fragrance preference varies according to the content of essential oil of Chopi.

Specifically, in the case of Examples 1 and 2, in which the content of essential bark oil was lower than that of Example 3, the characteristic fragrance of essential oil was weak, and the flavor preference was not good compared to Example 3, and Example 4 in which the content of essential oil was higher than Example 3 In the case of , it can be seen that the average value of fragrance preference is lower than that of Example 3 because the characteristic fragrance of essential oil is too strong.

Experimental example 6. Incense Panel evaluation on the degree of improvement in preference and attention

For the cosmetic compositions prepared according to Example 3, Comparative Example 1, and Comparative Example 2, 16 healthy adults were sprayed 3 times with the cosmetic composition contained in the container on the back of the hand in a closed space, and then scented for 15 seconds. After inhalation, preference for scent and degree of improvement in concentration were evaluated. Evaluation was carried out according to the following average standard, and the results obtained at this time are shown in FIGS. 3, 4, and 6 .

<Evaluation criteria>

Low preference for fragrance/Low improvement in attention concentration: 1 point

Scent preference Moderate/Attention level improvement Moderate: 5 points

High preference for fragrance/High degree of improvement in attention: 10 points

scent preference Degree of improvement in attention panel 1 Comparative Example 1 5 10 Comparative Example 2 One One Example 3 One 5 panel 2 Comparative Example 1 5 10 Comparative Example 2 One 10 Example 3 5 10 panel 3 Comparative Example 1 One 5 Comparative Example 2 One One Example 3 10 10 panel 4 Comparative Example 1 10 5 Comparative Example 2 5 5 Example 3 10 10 panel 5 Comparative Example 1 5 10 Comparative Example 2 5 10 Example 3 10 5 panel 6 Comparative Example 1 10 10 Comparative Example 2 5 10 Example 3 One 5 panel 7 Comparative Example 1 10 5 Comparative Example 2 10 10 Example 3 5 5 panel 8 Comparative Example 1 5 5 Comparative Example 2 One One Example 3 One One panel 9 Comparative Example 1 10 10 Comparative Example 2 One One Example 3 10 5 panel 10 Comparative Example 1 One 5 Comparative Example 2 One 5 Example 3 5 5 panel 11 Comparative Example 1 5 One Comparative Example 2 One One Example 3 5 5 panel 12 Comparative Example 1 One 10 Comparative Example 2 5 5 Example 3 5 10 panel 13 Comparative Example 1 5 5 Comparative Example 2 One 5 Example 3 5 10 panel 14 Comparative Example 1 10 One Comparative Example 2 One 5 Example 3 10 One panel 15 Comparative Example 1 One One Comparative Example 2 5 5 Example 3 10 10 panel 16 Comparative Example 1 One One Comparative Example 2 5 5 Example 3 10 10 medium Comparative Example 1 5.3 5.9 Comparative Example 2 3.1 5.0 Example 3 6.4 6.7

As shown in FIGS. 3 and 4 and Table 6 below, it can be confirmed that the cosmetic composition according to the present invention has excellent fragrance preference and improvement in concentration.

Specifically, in the case of the cosmetic composition according to Comparative Examples 1 or 2 containing only one of the bark essential oil or the bark distillate, the effect of improving fragrance preference and concentration compared to the cosmetic composition according to Example 3 containing both the bark oil and the bark distillate It can be seen that is significantly lower.

Experimental example 7. Evaluation of changes in attentional concentration index through EEG measurement

In order to verify the concentration improvement effect of the cosmetic compositions prepared according to Example 3, Comparative Example 1, and Comparative Example 2, EEG measurements were performed using a MindWave Mobile 2 EEG headsets device. At this time, the concentration measurement algorithm developed by NeuroSky Lab was used, and the concentration index value can be measured from 0 to 100.

Specifically, in 16 healthy adults, after wearing an EEG headset, in a stable state, open eyes for 15 seconds, then close eyes and check EEG for 15 seconds, and wait for 15 seconds. NeuroSky Lab's protocol (measured according to a standard measurement method. After that, the cosmetic composition was sprayed twice on the back of the hand, and the concentration index was measured in the same way while smelling for 15 seconds. The results obtained at this time are shown in FIGS. 5 to 7 and Table 7 indicated.

Average value of attention index rate of change
(unit: %) before smelling after smelling Comparative Example 1 50.42 49.89 -1.05 Comparative Example 2 48.72 47.77 -1.94 Example 3 48.36 52.05 7.63

As shown in Table 7 and FIG. 4 below, the concentration index before and after smelling the cosmetic composition decreased in Comparative Examples 1 and 2, whereas in Example 3, it increased at a high rate, through which the present invention It can be confirmed that the effect of improving concentration of the cosmetic composition according to the present invention is excellent.

Specifically, FIGS. 5 and 6 are graphs showing changes in the attention index of panels 3 and 4, respectively, and it can be seen that the attention index significantly increases after inhaling the fragrance of the cosmetic composition of Example 3 compared to before inhaling.

Therefore, it can be seen that the cosmetic composition according to the present invention exhibits an effect of improving concentration.

Formulation example 1. Cream

According to the composition and content of Table 8 below, a cream containing the composition for enhancing concentration of the present invention was prepared in a conventional manner.

ingredient content
(Unit: % by weight) Chopi essential oil 0.05 bark distillate 92 Glyceryl Stearate Citrate 0.5 cetylhexanoate One Ammonium Acryloyl Dimethyl Taurate/Vpicopolymer 0.4 dimethicone 3 Butylene Glycol 3 Ethylhexylglycerin 0.05

Claims (12)

A composition for enhancing concentration, comprising a bark distillate and essential oil of bark skin as active ingredients. The method of claim 1,
The skin distillate is contained in an amount of 33.3 to 99.9% by weight based on 100% by weight of the composition for improving concentration, the composition for improving concentration. According to claim 1,
The chopi essential oil is included in an amount of 0.01 to 0.1% by weight based on 100% by weight of the composition for improving concentration, the composition for improving concentration. According to claim 1,
The bark distillate and bark essential oil is a bark extract obtained by extracting the bark from the steam distillation method, a composition for enhancing concentration. 5. The method of claim 4,
The bark distillate is an aqueous layer component of the bark extract, a composition for enhancing concentration. 5. The method of claim 4,
The herbal essential oil is a component of the oil layer of the bark extract, a composition for enhancing concentration. A cosmetic composition comprising the composition for enhancing concentration according to claim 1. 8. The method of claim 7,
The cosmetic composition has an antibacterial effect. 8. The method of claim 7,
The cosmetic composition has a skin soothing effect, a cosmetic composition. A fragrance composition comprising the composition for enhancing concentration according to claim 1 . A fragrance composition comprising the composition for enhancing concentration according to claim 1 . A quasi-drug composition comprising the composition for enhancing concentration according to claim 1.

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