JP3503879B2 - Cosmetics - Google Patents
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- JP3503879B2 JP3503879B2 JP19293799A JP19293799A JP3503879B2 JP 3503879 B2 JP3503879 B2 JP 3503879B2 JP 19293799 A JP19293799 A JP 19293799A JP 19293799 A JP19293799 A JP 19293799A JP 3503879 B2 JP3503879 B2 JP 3503879B2
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- Japan
- Prior art keywords
- acid
- zinc oxide
- acne
- cosmetic composition
- hydroxycarboxylic acid
- Prior art date
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Description
【発明の詳細な説明】Detailed Description of the Invention
【０００１】[0001]
【発明の属する技術分野】本発明は、ニキビの予防・改
善効果に優れた化粧料に関する。TECHNICAL FIELD The present invention relates to a cosmetic composition which is excellent in preventing and improving acne.
【０００２】[0002]
【従来の技術】ニキビは脂漏性の皮膚疾患で、皮脂の過
剰排出等が原因とされている。ニキビを予防・改善する
には、皮脂の過剰排出を抑制する、過剰に排出された皮
脂を取り除く等の方法がある。皮脂の過剰排出を抑制す
る剤として、ヒドロキシカルボン酸が知られている（米
国特許第３９２０８３５号等）。しかし、ヒドロキシカ
ルボン酸は、特有の臭いがあったり、化粧料に単に配合
するだけでは十分な効果が得られない等の問題があっ
た。2. Description of the Related Art Acne is a seborrheic skin disease and is caused by excessive discharge of sebum. In order to prevent and improve acne, there are methods such as suppressing excessive discharge of sebum and removing excessively discharged sebum. Hydroxycarboxylic acid is known as an agent for suppressing excessive discharge of sebum (US Pat. No. 3,920,835). However, the hydroxycarboxylic acid has a problem that it has a peculiar odor and that a sufficient effect cannot be obtained by simply blending it with a cosmetic.
【０００３】一方、過剰排出された皮脂を取り除くた
め、アルコール類で拭き取ったり、酸化亜鉛等の粉体に
吸収させる方法があるが、いずれも十分な皮脂除去機能
を果たせない。On the other hand, in order to remove the excessively discharged sebum, there are methods such as wiping with alcohol or absorbing with powder such as zinc oxide, but none of them can fulfill a sufficient sebum removing function.
【０００４】[0004]
【発明が解決しようとする課題】本発明の目的は、ニキ
ビの予防・改善効果に優れた化粧料を提供することにあ
る。SUMMARY OF THE INVENTION An object of the present invention is to provide a cosmetic composition which is excellent in preventing and improving acne.
【０００５】[0005]
【課題を解決するための手段】本発明者らは、ヒドロキ
シカルボン酸で表面処理した酸化亜鉛が、高い皮脂分泌
抑制効果を有し、これを用いればニキビの予防・改善効
果に優れた化粧料が得られることを見出した。Means for Solving the Problems The present inventors have found that zinc oxide surface-treated with hydroxycarboxylic acid has a high sebum secretion inhibitory effect, and if it is used, a cosmetic excellent in the prevention / amelioration effect of acne is obtained. It was found that
【０００６】本発明は、一般式（１） R 1 -(CH 2 ) n -COOH ・・・・（１） （式中、Ｒ 1 は１又は２以上のヒドロキシル基で置換さ
れた炭素数１〜８のアルキル基を示し、ｎは１〜１８の
数を示す）で表わされ、総炭素数６〜２０の
ヒドロキシ
カルボン酸で表面処理した酸化亜鉛を含有する化粧料を
提供するものである。The present invention has the general formula (1) R 1- (CH 2 ) n -COOH ... (1) (wherein R 1 is substituted with one or more hydroxyl groups.
Represents an alkyl group having 1 to 8 carbon atoms, n is 1 to 18
The present invention provides a cosmetic containing zinc oxide whose surface is treated with a hydroxycarboxylic acid having 6 to 20 carbon atoms .
【０００７】[0007]
【発明の実施の形態】本発明で用いるヒドロキシカルボ
ン酸は、一般式（１）BEST MODE FOR CARRYING OUT THE INVENTION The hydroxycarboxylic acid used in the present invention has the general formula (1):
【０００８】[0008]
【化２】R1-(CH2)n-COOH …………（１）[Chemical formula 2] R 1- (CH 2 ) n -COOH ………… (1)
【０００９】（式中、Ｒ1は１又は２以上のヒドロキシ
ル基で置換された炭素数１〜８のアルキル基を示し、ｎ
は１〜１８、好ましくは７〜１０の数を示す）で表わさ
れ、総炭素数６〜２０、好ましくは６〜１８のヒドロキ
シカルボン酸である。 (Wherein R 1 represents an alkyl group having 1 to 8 carbon atoms substituted with one or more hydroxyl groups, and n
Is a hydroxycarboxylic acid having 1 to 18, preferably 7 to 10, and having a total carbon number of 6 to 20, preferably 6 to 18 .
【００１０】一般式（１）で表わされるヒドロキシカル
ボン酸としては、末端（ω位）又は末端から６個目まで
の炭素原子にヒドロキシル基が置換したカルボン酸が好
ましく、６−ヒドロキシヘキサン酸、７−ヒドロキシオ
クタン酸、８−ヒドロキシオクタン酸、８−ヒドロキシ
ノナン酸、９−ヒドロキシノナン酸、１０−ヒドロキシ
デカン酸、１０，１１−ジヒドロキシウンデカン酸、９
−ヒドロキシウンデカン酸、１０−ヒドロキシウンデカ
ン酸、１０−ヒドロキシ−１０−メチルウンデカン酸、
１１−ヒドロキシウンデカン酸、１０−ヒドロキシドデ
カン酸、１２−ヒドロキシドデカン酸、１３−ヒドロキ
シトリデカン酸、１４−ヒドロキシテトラデカン酸、１
２−ヒドロキシステアリン酸等が好ましい。The hydroxycarboxylic acid represented by the general formula (1) is preferably a carboxylic acid having a hydroxyl group substituted at the terminal (ω-position) or at the 6th carbon atom from the terminal, and 6-hydroxyhexanoic acid, 7 -Hydroxyoctanoic acid, 8-hydroxyoctanoic acid, 8-hydroxynonanoic acid, 9-hydroxynonanoic acid, 10-hydroxydecanoic acid, 10,11-dihydroxyundecanoic acid, 9
-Hydroxyundecanoic acid, 10-hydroxyundecanoic acid, 10-hydroxy-10-methylundecanoic acid,
11-hydroxyundecanoic acid, 10-hydroxydodecanoic acid, 12-hydroxydodecanoic acid, 13-hydroxytridecanoic acid, 14-hydroxytetradecanoic acid, 1
2-hydroxystearic acid and the like are preferred.
【００１１】一方、表面処理される酸化亜鉛は、通常の
化粧料に用いられるものであれば特に限定されず、使用
できる。On the other hand, the surface-treated zinc oxide is not particularly limited as long as it is used in ordinary cosmetics and can be used.
【００１２】酸化亜鉛をヒドロキシカルボン酸で表面処
理するには、湿式法、乾式法、スプレードライ法等によ
り、常法に従って行うことができる。例えば、湿式法の
場合、ヒドロキシカルボン酸をエタノールに溶解した溶
液に、酸化亜鉛を分散、混合し、沈殿物を回収して得る
ことができる。酸化亜鉛がヒドロキシカルボン酸で表面
処理されていることは、赤外吸収スペクトルにて確認す
ることができる。The surface treatment of zinc oxide with hydroxycarboxylic acid can be carried out by a conventional method such as a wet method, a dry method or a spray dry method. For example, in the case of the wet method, it can be obtained by dispersing and mixing zinc oxide in a solution of hydroxycarboxylic acid dissolved in ethanol and collecting the precipitate. The fact that zinc oxide is surface-treated with hydroxycarboxylic acid can be confirmed by an infrared absorption spectrum.
【００１３】用いる酸化亜鉛とヒドロキシカルボン酸の
割合は、モル比で２：１〜１：５、特に２：１〜１：２
であるのが好ましい。The molar ratio of zinc oxide to hydroxycarboxylic acid used is 2: 1 to 1: 5, especially 2: 1 to 1: 2.
Is preferred.
【００１４】このようにして表面処理した酸化亜鉛は、
１種以上を用いることができ、全組成中に０．０００１
〜１０重量％、特に０．０００１〜５重量％、更に０．
００１〜３重量％配合するのが、製剤の安定性及び使用
感の点で好ましい。Zinc oxide surface-treated in this way is
One or more kinds can be used, and 0.0001 in the total composition
-10 to 10% by weight, especially 0.0001 to 5% by weight, and further 0.
It is preferable to add 001 to 3% by weight from the viewpoint of the stability of the preparation and the feeling of use.
【００１５】本発明の化粧料には、更に抗炎症作用を有
する植物抽出物又はイオウを配合でき、ニキビ改善効果
をより高めることができる。The cosmetic composition of the present invention may further contain a plant extract or sulfur having an anti-inflammatory effect, and the acne improving effect can be further enhanced.
【００１６】抗炎症作用を有する植物抽出物としては、
例えばオウゴン、オウバク、カミツレ、シャクヤク、タ
イソウ、チャ、トウキ、モモ、アマチャ、アスナロ、ア
ルニカ、イチョウ、インチンコウ、ウコン、オウレン、
オトギリソウ、オランダカラシ、クマザサ、ゲンチア
ナ、コジソウ、コンフリー、サルビア、サンザシ、サン
ショウ、シソ、ジュウヤク、セイヨウノコギリソウ、セ
イヨウハッカ、ソウハクヒ、タイム、チョウジ、トウキ
ンセンカ、トウニン、パセリ、ハマメリス、ビワ、ブッ
チャーブルーム、ブドウ、ボダイジュ、マンネンロウ、
ボタンピ、ヤグルマギク、ラベンダー、ローマカミツ
レ、ドクダミ等の抽出物が挙げられる。これらのうち、
ビワ、ドクダミ、コンフリー、ボダイジュ、ローマカミ
ツレ等の抽出物が好ましい。As the plant extract having an anti-inflammatory effect,
For example, Scutellaria, Saccharum, Chamomile, Peonies, Thyrus, Cha, Touki, Peach, Amacha, Asunaro, Arnica, Ginkgo, Inchinko, Turmeric, Oren,
St. John's wort, Dutch mustard, beargrass, gentian, kojisou, comfrey, salvia, hawthorn, salamander, perilla, juyaku, yarrow, yarrow, mint, soybean, thyme, clove, calendula, toinin, parsley, hamamelis, loquat, butcherbush , Grapes, bodaiju, mannen wax,
Examples include extracts such as peanut, cornflower, lavender, Roman chamomile, Dodami. Of these,
Extracts such as loquat, dokudami, comfrey, bodige, Roman chamomile and the like are preferable.
【００１７】これらの植物抽出物は、常法により各植物
から抽出した抽出液又は市販品の１種以上を用いること
ができ、全組成中に抽出液として、０．０００１〜３０
重量％、特に０．０００１〜１０重量％、更に０．００
０５〜５重量％配合するのが、色、匂い等の点から好ま
しい。As these plant extracts, one or more kinds of extracts or commercial products extracted from each plant by a conventional method can be used, and 0.0001 to 30 as an extract in the entire composition.
% By weight, in particular 0.0001 to 10% by weight, even 0.00
It is preferable to mix it in an amount of 05 to 5% by weight from the viewpoint of color, smell and the like.
【００１８】また、イオウは、全組成中に０．０００１
〜５重量％、特に０．０００１〜３重量％、更に０．０
００１〜１重量％配合するのが好ましい。本発明におい
ては、植物抽出物及びイオウを併用することもできる。Further, sulfur is 0.0001 in the total composition.
-5% by weight, in particular 0.0001-3% by weight, and further 0.0
It is preferable to add 001 to 1% by weight. In the present invention, a plant extract and sulfur can be used in combination.
【００１９】本発明の化粧料には、前記成分のほか、通
常化粧料に用いられる成分、例えばセラミド類、セラミ
ド類似物質（特開平８−３１９２６３号等に記載のも
の）、アミノ酸類、前記以外の植物抽出物、ステロール
類、多糖類、アルコール類、油性成分、シリコーン類、
フッ素系油剤、ヒドロキシ酸類、エタノール、精製水、
界面活性剤、保湿剤、美白剤、前記以外の抗炎症剤、一
重項酸素消去剤、抗酸化剤、血行促進剤、紫外線防御
剤、前記以外の粉体、油ゲル化剤、皮膜形成剤、柔軟
剤、pH調整剤、防腐剤、金属イオン封鎖剤、色素、香料
等を適宜配合でき、常法により製造できる。In addition to the above-mentioned components, the cosmetics of the present invention include components usually used in cosmetics, such as ceramides, ceramide-like substances (described in JP-A-8-319263, etc.), amino acids, and other than the above. Plant extracts of, sterols, polysaccharides, alcohols, oily ingredients, silicones,
Fluorine-based oil, hydroxy acids, ethanol, purified water,
Surfactants, moisturizers, whitening agents, anti-inflammatory agents other than the above, singlet oxygen scavengers, antioxidants, blood circulation promoters, UV protective agents, powders other than the above, oil gelling agents, film forming agents, A softening agent, a pH adjuster, an antiseptic, a sequestering agent, a dye, a fragrance, etc. can be added as appropriate and can be produced by a conventional method.
【００２０】本発明の化粧料は、種々の製品形態、例え
ばクリーム、化粧乳液、化粧水、美容液、マッサージ化
粧料、パック剤、口紅、ファンデーション、皮膚洗浄剤
等の皮膚化粧料；ヘアートニック、整髪剤、養毛剤、育
毛剤等の毛髪化粧料；その他医薬部外品、外用医薬品と
することができ、特にニキビ改善化粧料として好適であ
る。また、その剤型も目的に応じて選択でき、クリーム
状、軟膏状、乳液状、ローション状、溶液状、ゲル状、
パウダー状、スティック状等とできる。The cosmetics of the present invention can be used in various product forms, for example, skin cosmetics such as creams, lotions, lotions, beauty essences, massage cosmetics, packs, lipsticks, foundations and skin cleansers; It can be used as a hair cosmetic such as a hair styling agent, a hair nourishing agent, and a hair restorer; other quasi-drugs and external medicines, and is particularly suitable as an acne improving cosmetic. In addition, the dosage form can be selected according to the purpose, cream, ointment, emulsion, lotion, solution, gel,
It can be in powder form, stick form, etc.
【００２１】[0021]
【発明の効果】本発明の化粧料は、ニキビ、特に脂漏性
ニキビ、炎症性ニキビの予防・改善効果に優れたもので
ある。The cosmetics of the present invention are excellent in the preventive / ameliorating effect on acne, particularly seborrheic acne and inflammatory acne.
【００２２】[0022]
【実施例】製造例１（１０−ヒドロキシウンデカン酸表
面処理酸化亜鉛の製造）
１０−ヒドロキシウンデカン酸１００ｇ（０．４９mo
l）及びエタノール１０００ｇをフラスコに入れ、室温
で１時間攪拌した。次いで、酸化亜鉛２０ｇ（０．２５
mol）を攪拌しながら、徐々に加え、更に３０分間攪拌
した。沈殿物を濾過して水で洗浄し、減圧乾燥すること
により、１０−ヒドロキシウンデカン酸表面処理酸化亜
鉛７９．２ｇ（収率６６．０％）を得た。得られた酸化
亜鉛は、赤外吸収スペクトルにより、ヒドロキシカルボ
ン酸で表面処理されていることが確認された。EXAMPLES Production Example 1 (Production of 10-hydroxyundecanoic acid surface-treated zinc oxide) 100 g of 10-hydroxyundecanoic acid (0.49 mo
l) and 1000 g of ethanol were placed in a flask and stirred at room temperature for 1 hour. Then, 20 g of zinc oxide (0.25
(mol) was gradually added with stirring, and the mixture was further stirred for 30 minutes. The precipitate was filtered, washed with water, and dried under reduced pressure to obtain 79.2 g of 10-hydroxyundecanoic acid surface-treated zinc oxide (yield 66.0%). The obtained zinc oxide was confirmed to be surface-treated with hydroxycarboxylic acid by infrared absorption spectrum.
【００２３】実施例１
ヒドロキシカルボン酸表面処理酸化亜鉛のエタノール分
散液（０．５重量％濃度）を製造し、その皮脂分泌抑制
効果を評価した。結果を表１に示す。Example 1 An ethanol dispersion (0.5 wt% concentration) of hydroxycarboxylic acid surface-treated zinc oxide was produced and its sebum secretion inhibitory effect was evaluated. The results are shown in Table 1.
【００２４】（評価方法）２５〜３５才の健常男子５人
を被験者とし、それぞれ左右いずれかの鼻綾側に、上記
分散液を１日２回朝夕、２週間塗布した。このような処
理前、及び２週間後において、洗顔を行い、洗顔１時間
後の各被験者の回復皮脂量を、SEBUTAPE PRO KIT（CUDE
RM社製）を用いて測定し、塗布部と未塗布部の回復皮脂
量比を求めた。(Evaluation Method) Five healthy males aged 25 to 35 were used as test subjects, and the above dispersion was applied twice a day twice a day in the morning and evening for two weeks on the nasal twill side. Before such treatment, and after 2 weeks, a face wash was performed, and the amount of sebum recovered by each subject one hour after the face wash was measured by SEBUTAPE PRO KIT (CUDE
(Manufactured by RM) was used to determine the ratio of the amount of recovered sebum between the coated part and the uncoated part.
【００２５】[0025]
【表１】 [Table 1]
【００２６】表１の結果から明らかなように、試料塗布
側の皮脂分泌抑制効果が顕著である。As is clear from the results in Table 1, the sebum secretion inhibitory effect on the sample application side is remarkable.
【００２７】実施例２
表２及び３に示す組成の化粧料を常法により製造し、そ
のニキビ改善効果を評価した。結果を表２及び３に併せ
て示す。Example 2 Cosmetics having the compositions shown in Tables 2 and 3 were produced by a conventional method, and their acne improving effect was evaluated. The results are also shown in Tables 2 and 3.
【００２８】（評価方法）顔面にニキビ症状を有する、
２５〜３５才の健常男子５人の、顔面右部に試験品を、
顔面左部に対照品を、１日２回朝夕、２週間塗布した。
その後、ニキビ症患部の改善効果を以下の判定基準に従
い、半顔比較法で判定した。その結果を５人の平均値で
示した。(Evaluation method) Acne symptoms on the face,
Five healthy boys aged 25 to 35 were tested on the right side of their face.
The control product was applied to the left side of the face twice a day in the morning and evening for 2 weeks.
Thereafter, the effect of improving the affected area of acne was determined by the half-face comparison method according to the following criteria. The result was shown by the average value of 5 persons.
【００２９】試験品は対照品と比較して 完全に治癒 ５点。 明らかに改善している ４点。 改善している ３点。 わずかに改善している ２点。 変化なし（差がない） １点。The test product compared to the control product Complete healing 5 points. 4 points that are clearly improving. 3 points that are improving. Two points that have improved slightly. No change (no difference) 1 point.
【００３０】[0030]
【表２】 [Table 2]
【００３１】[0031]
【表３】 [Table 3]
【００３２】実施例３ 以下に示す組成のローションを常法により製造した。Example 3 A lotion having the composition shown below was produced by a conventional method.
【表４】 （成分） （重量％） ８−ヒドロキシノナン酸表面処理酸化亜鉛 ０．５ エタノール ５．０ ポリオキシエチレンオクチルドデシルエーテル(20E.O.) １．０ イオウ ０．０３ グリセリン １０．０ コンフリー(Symphytum officinale)抽出物 （一丸ファルコス社製） ０．１ 水 残部[Table 4] (Component) (% by weight) 8-Hydroxynonanoic acid surface treated zinc oxide 0.5 Ethanol 5.0 Polyoxyethylene octyl dodecyl ether (20E.O.) 1.0 Sulfur 0.03 Glycerin 10.0 Comfrey (Symphytum officinale) extract (Made by Ichimaru Falcos) 0.1 Remaining water
【００３３】実施例４ 以下に示す組成の乳液を常法により製造した。Example 4 An emulsion having the composition shown below was produced by a conventional method.
【表５】 （成分） （重量％） ７−ヒドロキシオクタン酸表面処理酸化亜鉛 １．０ エタノール ５．０ イオウ ０．０５ ポリオキシエチレンオクチルドデシルエーテル(20E.O.) １．０ ポリオキシエチレン硬化ヒマシ油(60E.O.) ０．５ イソステアリルアルコール ０．８ ジカプリン酸ネオペンチルグリコール ５．０ ポリエチレングリコール１０００ ３．０ グリセリン １０．０ ビワ(Eriobotrya japonica) 抽出物（一丸ファルコス社製） ０．５ 水 残部[Table 5] (Component) (% by weight) 7-Hydroxyoctanoic acid surface treated zinc oxide 1.0 Ethanol 5.0 Sulfur 0.05 Polyoxyethylene octyl dodecyl ether (20E.O.) 1.0 Polyoxyethylene hydrogenated castor oil (60E.O.) 0.5 Isostearyl alcohol 0.8 Neopentyl glycol dicaprate 5.0 Polyethylene glycol 1000 3.0 Glycerin 10.0 Loquat (Eriobotrya japonica) extract (manufactured by Ichimaru Falcos) 0.5 Remaining water
【００３４】実施例５ 以下に示す組成の美容液を常法により製造した。Example 5 A beauty essence having the composition shown below was produced by a conventional method.
【表６】 （成分） （重量％） １０−ヒドロキシデカン酸表面処理酸化亜鉛 １．０ エタノール ５．０ イオウ ０．０２ シリコーン油（KF96A(6cs)、信越シリコーン社製） ４．０ ポリオキシエチレン変性シリコーン （SH3771E 、東レダウコーニング社製) ０．５ ポリオキシエチレン硬化ヒマシ油(40E.O.) ０．２ キサンタンガム ０．３ ポリアクリル酸ナトリウム ０．１ 水酸化カルシウム ０．０２５ グリセリン ２．０ コンフリー(Symphytum officinale)抽出物 （一丸ファルコス社製） ０．５ 水 残部[Table 6] (Component) (% by weight) 10-Hydroxydecanoic acid surface treated zinc oxide 1.0 Ethanol 5.0 Sulfur 0.02 Silicone oil (KF96A (6cs), Shin-Etsu Silicone Co., Ltd.) 4.0 Polyoxyethylene modified silicone (SH3771E, Toray Dow Corning) 0.5 Polyoxyethylene hydrogenated castor oil (40E.O.) 0.2 Xanthan gum 0.3 Sodium polyacrylate 0.1 Calcium hydroxide 0.025 Glycerin 2.0 Comfrey (Symphytum officinale) extract (Made by Ichimaru Falcos) 0.5 Remaining water
【００３５】実施例６
以下に示す組成のスティック剤型化粧料を常法により製
造した。Example 6 A stick-type cosmetic composition having the following composition was produced by a conventional method.
【表７】 （成分） （重量％） １０−ヒドロキシウンデカン酸表面処理酸化亜鉛 ３．０ イオウ ０．５ セレシン ４．７ 高融点パラフィン ６．２ ポリオレフィンワックス ２．４ ポリエチレンワックス ２．４ マイクロクリスタリンワックス ６．３ スクワラン １５．０ ジカプリン酸ネオペンチルグリコール ２５．０ ポリオキシエチレン硬化ヒマシ油(40E.O.) ０．５ ジメチルシロキサン ２７．０ グリセリン ５．０ ドクダミ(Houttuynia cordata)抽出物 （一丸ファルコス社製） ２．０[Table 7] (Component) (% by weight) 10-Hydroxyundecanoic acid surface treated zinc oxide 3.0 Sulfur 0.5 Ceresin 4.7 High melting point paraffin 6.2 Polyolefin wax 2.4 Polyethylene wax 2.4 Microcrystalline wax 6.3 Squalane 15.0 Neopentyl glycol dicaprate 25.0 Polyoxyethylene hydrogenated castor oil (40E.O.) 0.5 Dimethylsiloxane 27.0 Glycerin 5.0 Houttuynia cordata extract (Made by Ichimaru Falcos) 2.0
【００３６】実施例３〜６で得られた化粧料はいずれ
も、ニキビ改善効果に優れていた。All the cosmetics obtained in Examples 3 to 6 were excellent in the effect of improving acne.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 山▲崎▼ 誠司 東京都墨田区文花２−１−３ 花王株式 会社研究所内 (56)参考文献 特開 平８−92028（ＪＰ，Ａ) 特開 昭63−166837（ＪＰ，Ａ) 特開 平８−208450（ＪＰ，Ａ) 特表 平10−502944（ＪＰ，Ａ) (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/00 - 7/50 A61K 33/30 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yama ▲ Saki ▼ Seiji Fumihana Sumida-ku, Tokyo 2-1-3 Kao Corporation Research Institute (56) Reference JP-A-8-92028 (JP, A) Kai 63-166837 (JP, A) JP 8-208450 (JP, A) Special table 10-502944 (JP, A) (58) Fields investigated (Int.Cl. 7 , DB name) A61K 7 / 00-7/50 A61K 33/30
Claims (4)
れた炭素数１〜８のアルキル基を示し、ｎは１〜１８の
数を示す）で表わされ、総炭素数６〜２０の ヒドロキシ
カルボン酸で表面処理した酸化亜鉛を含有する化粧料。1. A compound represented by the general formula (1) R 1- (CH 2 ) n -COOH ... (1) (wherein R 1 is substituted with one or more hydroxyl groups.
Represents an alkyl group having 1 to 8 carbon atoms, n is 1 to 18
The cosmetic composition contains zinc oxide whose surface is treated with a hydroxycarboxylic acid having 6 to 20 carbon atoms .
が、モル比で２：１〜１：５である請求項１記載の化粧
料。 2. Ratio of zinc oxide and hydroxycarboxylic acid
Is 2: 1 to 1: 5 in a molar ratio.
Fee.
はイオウを含有する請求項１又は２記載の化粧料。3. The cosmetic composition according to claim 1 or 2, further comprising a plant extract or sulfur having an anti-inflammatory effect.
いずれか１項記載の化粧料。4. The cosmetic composition according to claim 1, which is an acne-improving cosmetic composition.
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| JP19293799A JP3503879B2 (en) | 1999-07-07 | 1999-07-07 | Cosmetics |
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| JP3503879B2 true JP3503879B2 (en) | 2004-03-08 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002284626A (en) * | 2001-03-23 | 2002-10-03 | Nippon Hypox Lab Inc | External skin preparation |
| KR100515764B1 (en) * | 2002-10-19 | 2005-09-21 | 김기철 | Face cleansing agent |
| JP6650276B2 (en) * | 2016-01-21 | 2020-02-19 | 大東化成工業株式会社 | Antibacterial pigment and antibacterial composition |
| JP6311049B1 (en) * | 2016-11-25 | 2018-04-11 | ロート製薬株式会社 | Acne prevention and / or treatment for back acne |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU618517B2 (en) * | 1986-12-23 | 1992-01-02 | Eugene J. Van Scott | Additives enhancing topical actions of therapeutic agents |
| JPH0892028A (en) * | 1994-09-20 | 1996-04-09 | Shiseido Co Ltd | Cosmetic for body |
| DE4438588A1 (en) * | 1994-10-28 | 1996-05-02 | Beiersdorf Ag | Against blemished skin, mild forms of acne and Propionibacterium acnes active ingredient combinations based on wool wax acids and glycerol esters of saturated fatty acids |
| US5648389A (en) * | 1995-10-27 | 1997-07-15 | Medicis Pharmaceutical, Inc. | Compositions for the treatment of dermatological disorders and methods for their use |
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