JP2010143884A - Chapped skin improving agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a chapped skin improving agent excellent in usability and effect. <P>SOLUTION: The chapped skin improving agent is characterized in including 1,3,5-trimethoxybenzene and/or 1,4-dimethoxybenzene. <P>COPYRIGHT: (C)2010,JPO&amp;INPIT

Description

  The present invention relates to a rough skin improving agent having excellent usability, and more particularly, to a rough skin improving agent capable of recovering rough skin by applying or sucking to the skin, and a composition containing the same.

Rough skin is a skin trouble caused by external factors such as dryness, ultraviolet rays, irritating substances such as detergents and chemicals, and internal factors such as hormonal balance disturbances, and deterioration of the stratum corneum barrier function, It is accompanied by phenomena such as a decrease in stratum corneum moisture, an increase in epidermis turnover, and roughening of the keratin due to the generation of scaling (scaling). In particular, roughening of the keratin may worsen the makeup paste, and is a cosmetic problem for many women.
Conventionally, for the purpose of improving rough skin, a method of supplementing the stratum corneum barrier function with an occlusive agent such as petrolatum ointment or water-in-oil emulsion formulation, a method of supplementing the stratum corneum water content with a moisturizer such as sorbitol or glycerin, glycyrrhetic acid A method of suppressing skin inflammation with an anti-inflammatory agent and a method of activating skin cells with vitamins, hormones and the like have been used.
On the other hand, in recent years, there has been an increasing interest in aromatherapy (aroma therapy) as a treatment that can be used easily and has relatively few side effects, and is particularly effective for psychosomatic disorders such as indefinite complaints based on stress predisposition and autonomic ataxia. It is attracting attention as. Among them, various fragrances exist as aroma therapeutic agents for improving various symptoms, and there are also fragrances that are effective for improving skin.

However, none of the above known methods have sufficient skin moisture retention ability, and the effect of improving keratin is small, and when an occlusive agent is used, it is oily and uncomfortable such as stickiness. On the other hand, in order to enhance the effect even when a moisturizing agent is used, it has to be blended in a large amount, resulting in an unpleasant feeling such as a sticky feeling or a slimy feeling. was there. In addition, the skin improvement effect by aromatherapy is vaguely based on empirical judgment, and there are few fragrances known to have a specific specific pharmacological effect like ordinary drugs. Furthermore, although research on the mental effects of fragrances has been relatively conducted, few studies have attempted to improve skin function through inhalation of fragrances.

Patent Document 1 describes that 1,3,5-trimethoxybenzene promotes cell proliferation of the epidermis as a phloroglucinol derivative, but its relation with improvement of rough skin has been studied. Absent. Further, terpenyl acetate, dimethoxymethylbenzene and the like are also known to have an effect of promoting the recovery of skin barrier function (Patent Document 2), but the 1,4-dimethoxybenzene of the present invention is known to improve the rough skin. Not. In addition, 1,4-dimethoxybenzene is known as a compound having a lotus-like fragrance (Patent Document 3) and has been confirmed by the present inventors to have a sedative effect. (Patent Document 4)

Japanese Patent Laid-Open No. 11-246328 JP 2000-159666 A JP-A-4-159399 JP 2006-290823 A

  The present invention has been made in view of the above circumstances, and has an object to provide a rough skin improving agent that has no drawbacks in use such as stickiness, has excellent usability when applied to the skin, and is effective in improving rough skin during suction. Do

  As a result of diligent studies by the present inventor to achieve the above-mentioned object, di- or trialkoxybenzene, particularly 1,3,5-trimethoxybenzene and 1,4-dimethoxybenzene, are excellent in usability and are applied or sucked. It was found that the effect of improving the rough skin at the time was excellent, and 1,4-dimethoxybenzene was found to be excellent in the sustainability of moisturizing, and the present invention was completed.

That is, the present invention provides a rough skin improving agent comprising dimethoxybenzene and / or trimethoxybenzene.
The present invention also provides a rough skin improving agent, wherein the dimethoxybenzene is 1,4-dimethoxybenzene.
The present invention also provides a rough skin improving agent, wherein the trimethoxybenzene is 1,3,5-trimethoxybenzene.
Moreover, this invention provides the composition characterized by mix | blending the rough skin improvement agent of this application.

  According to the present invention, there are provided a rough skin improving agent having no problem in usability such as stickiness, excellent skin roughening effect and excellent moisturizing sustainability, and a composition containing the same.

Hereinafter, the present invention will be described in detail.
Any dialkoxybenzene or trialkoxybenzene used in the present invention may be used as long as it is industrially available. Preferably, 1,4-dimethoxybenzene and 1,3,5-trimethoxybenzene are preferably used in terms of usability and palatability.
Of these, one can be used alone, or two or more can be used in combination.
When mix | blending in a composition as a rough skin improving agent, about 0.001-50 mass% is preferable from the point of usability and palatability. If it is 0.001% by mass or less, the effect is poor, and if it exceeds 50% by mass, the usability tends to deteriorate.

When the rough skin improving agent of the present invention is blended in a composition, it can take any dosage form suitable for cosmetics, pharmaceuticals, sundries, foods, etc., as long as the effects of the present invention are not impaired. Other ingredients used in foods, pharmaceuticals, miscellaneous goods, foods, such as powder ingredients, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, silicones, anionic surfactants, cationic surfactants , Amphoteric surfactants, nonionic surfactants, humectants, water-soluble polymer compounds, thickeners, film agents, UV absorbers, sequestering agents, lower alcohols, polyhydric alcohols, sugars, amino acids, organic Amines, synthetic resin emulsions, pH adjusters, skin nutrients, vitamins, antioxidants, antioxidant assistants, fragrances, water, and the like can be appropriately blended as necessary. Specific examples of components that can be blended are listed below, but the cosmetic for improving rough skin of the present invention may be produced by a conventional method by blending any one or more of these components with the above essential components. it can.

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto. Unless otherwise specified, the blending amount is expressed in mass% with respect to the system in which the component is blended.
Prior to the examples, test methods and evaluation criteria for each evaluation used in this example will be described.

[Rough skin recovery test]
The rough skin recovery effect was measured by the recovery from experimental rough skin by tape stripping, using the amount of transdermal moisture transpiration as an index. The measurement site was the inner part of the forearm, and the transdermal water transpiration was measured with a VAPO meter (Delfin).
Subjects (8 healthy women in their 20s per subject) were rested for 1 hour after entering the room, and their inner arms were acclimatized to the room environment. Then, after measuring the resting value with a VAPO meter, experimental skin roughness was caused by tape stripping on the inner arm 2 cm × 2 cm while inhaling the test substance (described below), and mental stress by the color word test was subsequently continued. Loaded for 1 hour. Transdermal moisture transpiration was measured with a VAPO meter immediately after tape stripping, 1.5 hours and 3 hours later. The recovery rate was determined by (Equation 1) shown below. The effect of the test substance was determined by comparison with the case where the test substance was not presented in the same person.
(Formula 1) Recovery rate (%) = 100− (c−a) / (b−a) × 100
a: VAPO value at rest b: VAPO value immediately after tape stripping c: VAPO value after 1.5 hours or 3 hours (test substance and control, application method)
1,3,5-trimethoxybenzene: A cotton soaked with 20 uL of a 5% alcohol solution was affixed under the nose, inhaled with spontaneous breathing, and replaced with a fresh sample every 60 minutes.
1,4-Dimethoxybenzene: A cotton impregnated with 7.5 uL of a 1% alcohol solution was applied under the nose, inhaled with spontaneous breathing, and replaced with a fresh sample every 60 minutes.
As a control, a cotton soaked with 20 uL or 7.5 uL of only alcohol as a solvent was applied under the nose, inhaled with spontaneous breathing, and replaced with a fresh sample every 60 minutes.

Test examples 1 and 2
20 uL (Test Example 1) of a 5% alcohol solution of 1,3,5-trimethoxybenzene as a test substance, 7.5 uL (Test Example 2) of a 1% alcohol solution of 1,4-dimethoxybenzene, and a solvent as a control A cotton soaked with 20 uL or 7.5 uL of alcohol only was applied to the bottom of the nose, and the rough skin recovery rate was evaluated based on the above evaluation method. The results are shown in FIGS.

  (Figure 1)

  (Figure 2)

As shown in FIGS. 1 and 2, it can be seen that 1,3,5-trimethoxybenzene and 1,4-dimethoxybenzene have a rough skin recovery (improvement) effect.

[Moisturizing test]
The inner part of the upper arm was washed with soap and then opened at room temperature for 1 hour. One hour later, the water content was measured with a corneometer, and then each test substance (Table 1) was applied at 2 μl / cm 2, and the corneometer value after 30 minutes and 60 minutes was measured. The relative value compared with the said value by using 50% ethanol used as a solvent as a control is shown by the following evaluation.
◎ (very good): more than 3 times
○ (excellent): 1.5 times or more to less than 3 times x (inferior): less than 1.5 times

Test example 3
Each test substance shown in Table 1 below was used as a sample and evaluated by the above evaluation method. The results are shown in Table 1.

(Table 1) Corneometer value after application of each test substance ____________________________________
30 minutes later 60 minutes later ____________________________________________
5% sorbitol ◎ ×
5% 1,4-dimethoxymethylbenzene ○ ○
___________________________________

As shown in Table 1, sorbitol which is a rough skin improving agent of the present invention and a general moisturizing agent does not maintain moisturizing power, whereas 1,4-dimethoxybenzene changes moisturizing power after 30 minutes and 60 minutes. The effect on the retention of moisture retention was confirmed. It can be seen that it not only has an excellent effect on recovery of the skin barrier, but also has excellent retention of moisture retention for a long time.

[Composition example]
Although the compounding example which mix | blended the rough skin improving agent of this invention is shown below, it is not limited to these examples at all.

Formulation Example 1 Skin lotion component Amount (% by mass)
(1) 1,3-butylene glycol 6.0
(2) Glycerin 4.0
(3) Oleyl alcohol 0.1
(4) POE (20) sorbitan monolaurate 0.5
(5) POE (15) lauryl alcohol ester 0.5
(6) Ethanol 10.0
(7) Skin roughening agent of the present application (1,4-dimethoxybenzene) 3.0
(8) Purified water residue (production method)
(8) (1) and (2) were dissolved in purified water at room temperature to obtain an aqueous phase. (6) (3), (4) and (5) were dissolved in ethanol and mixed and solubilized in the previous aqueous phase. (7) was then added. Thereafter, it was filtered and filled to obtain a lotion.

Formulation Example 2 Gel-like serum component (1) Sodium polyacrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 2.0
(2) (Dimethicone / Vinyl Dimethicone) Cross Polymer / Dimethicone Mixture (Non-emulsifiable cross-linked silicone content 0.75%) 3.0
(3) Dimethicone 5cs 5.0
(4) POE (20) behenyl ether 0.5
(5) Ethanol 5.0
(6) Phenoxyethanol 0.5
(7) Fragrance 0.1
(8) Ion exchange water Residual (9) Glycerin 5.0
(10) 1,3-butylene glycol 3.0
(11) Byaclenca extract 0.1
(12) Japanese Root Extract 0.1
(13) Artemisia extract 0.1
(14) Tokyo extract 0.1
(15) Button extract 0.1
(16) Skin roughening agent of the present application (1,4-dimethoxybenzene) 0.5
(Manufacturing method)
To the aqueous phase in which (1) and (5) to (16) are uniformly dissolved, the mixture of (2) to (4) dissolved by heating is added and dispersed uniformly with a disper. Deaeration, cooling, and filtration were performed to obtain a gel serum.

: It is a figure which shows the rough skin recovery rate of 1.5 hours after 1,3,5-trimethoxybenzene after 3 hours. : It is a figure which shows the rough skin recovery | restoration rate 1.5 hours later and 3 hours after 1, 4- dimethoxybenzene.

Claims (4)

  A rough skin improving agent comprising dimethoxybenzene and / or trimethoxybenzene.   The rough skin-improving agent according to claim 1, wherein the dimethoxybenzene is 1,4-dimethoxybenzene.   3. The rough skin improving agent according to claim 1, wherein the trimethoxybenzene is 1,3,5-trimethoxybenzene.   A rough skin improving composition comprising 0.001 to 50% by mass of the rough skin improving agent according to any one of claims 1 to 3.