JP4658568B2 - Body sheet material - Google Patents

Description

  The present invention relates to a sheet material for body patching, which allows carbon dioxide to act on the skin and obtains a preventive and therapeutic effect for skin diseases and a cosmetic effect due to its blood circulation promoting effect.

  Conventionally, as cosmetics using the blood circulation promoting action of carbon dioxide, cosmetics that promote blood flow containing carbon dioxide in a pressure-resistant container (Patent Document 1), so as to promote carbon dioxide penetration into the skin. Known are carbon dioxide-containing cosmetics containing 10 to 99.9% polyhydric alcohol (Patent Document 2), and cosmetics with high viscosity (Patent Document 3) to suppress volatilization of carbon dioxide after jetting. It has been. However, these forms use a high-pressure gas container (aerosol can), or put a liquid (including high-viscosity gel) in a sealed container and squirt on the skin for use. The action time of carbon dioxide sprayed on the skin is extremely short, and there is a problem that a satisfactory blood circulation promoting effect cannot be obtained. In order to extend the action time of carbon dioxide, it was necessary to keep spray gel or the like thickly applied on the skin, and it was necessary to wipe off or wash away after use.

On the other hand, as a method of supplying carbon dioxide to the body without using a high-pressure vessel, etc., there is a technique of generating carbon dioxide gas by reacting carbonate and acid, but when using it for the body, it reacts Moisture and the like are necessary for this, and a complicated mechanism (Patent Document 4) is required as a place of use (tub) or form of use. On the other hand, there is a method (Patent Document 5) in which a cloth wetted with water is used repeatedly when used as a shipping agent, but the skin is inflamed due to the high concentration of salt solution adhering to the skin. There's a problem. Further, Patent Document 6 is known as a method for supplying carbon dioxide transcutaneously for the purpose of promoting wound healing of the skin, etc., but this is also a source of carbon dioxide, such as dry ice, carbonate and acid. In addition, it is complicated in terms of equipment such as supply from a cylinder, and the water permeation amount of the gas permeable material is very small, so that it is impossible to actually supply the water amount necessary for promoting blood circulation in the skin. Further, a carbon dioxide percutaneous absorption composition (Patent Document 7), which is a water-soluble polymer composition containing a high concentration of free carbonic acid and comprising a sol-gel transition composition, is known. It is described that this composition can suppress the volatilization of carbon dioxide gas by gelling, and it is shown that a sol in which a high concentration of carbon dioxide is dissolved is gelled after being applied to a sheet material. . However, there is no specific means for preventing the volatilization of carbon dioxide when applied to the sheet and when it is cooled and solidified, and it is difficult to actually supply carbon dioxide to the skin sufficiently. It is done. In addition, when processed on a sheet, there is a problem that the action is delayed (reddening for 5 minutes or more is delayed).
JP 59-141512 A JP-A-11-171755 Japanese Patent Laid-Open No. 11-228334 JP 2000-297007 A JP-A-62-286922 JP 2002-326938 A JP 2003-34612 A

  An object of the present invention is to provide a means for supplying carbon dioxide to the skin which is not irritating to the skin, can continuously supply carbon dioxide to the skin, and has good usability.

Then, this inventor devised making the sheet | seat containing the liquid or gel containing a carbon dioxide, and setting it as the form for body sticking. However, in this form, even if it is a gel sheet, carbon dioxide is volatilized, but this is sealed together with carbon dioxide in a packaging pillow that is hardly permeable to carbon dioxide, and further, the carbon dioxide in the liquid or gel. Adjust the pH of the liquid or gel to a certain range, adjust the pH of the liquid or gel, and adjust the filling ratio with respect to the weight of the sheet coated or impregnated with the liquid or gel to 0.1 to 40%. For example, carbon dioxide does not evaporate during storage, and it is only necessary to take out a body-adhesive sheet and apply it to the skin during use. The resulting blood circulation promoting effect and the amount of temporary blood in the subcutaneous tissue due to vasodilation It has been found that an increase occurs.
That is, the present invention is a body patch sheet material in which a sheet-like patch is sealed together with carbon dioxide in a carbon dioxide-impermeable packaging pillow, and the sheet-like patch is 100-3 at 25 ° C. A sheet-like patch having a liquid or gel having a pH of 3.5 to 6.5 in which 1,000 ppm of carbon dioxide is dissolved. The liquid with respect to the volume calculated from the inner surface area of the packaging pillow has a gel filling ratio of 0.1. The sheet material for body sticking characterized by being -40%, and its manufacturing method are provided.
The present invention also provides a sheet-like patch having a pH 3.5 to 6.5 solution or gel in which 100 to 3,000 ppm of carbon dioxide is dissolved at 25 ° C. in a packaging pillow that is hardly permeable to carbon dioxide. The present invention provides a packaging pillow that is filled and sealed together with carbon dioxide so that the filling ratio of the liquid or gel to the volume calculated from the inner surface area of the packaging pillow is 0.1 to 40%.

  According to the present invention, carbon dioxide can be quickly and continuously supplied to an application site without any skin irritation and with a simple operation. As a result, an effective and continuous blood circulation promoting effect can be obtained within the application time. For this reason, the sheet material for body patch of the present invention can be applied to cosmetics that can be expected to be effective in improving blood flow of the skin, prevention and treatment of pressure ulcers, prevention and treatment of swelling and edema, anti-inflammatory analgesics and the like. it can.

  For example, as shown in FIG. 1, the sheet material for body sticking of the present invention is formed by sealing (A) the sheet-like patch together with (B) carbon dioxide in (C) carbon dioxide-impermeable packaging pillows. Is.

(A) A sheet-like patch is a sheet-like patch having a solution or gel having a pH of 3.5 to 6.5 in which 100 to 3,000 ppm of carbon dioxide is dissolved at 25 ° C. Examples of the form of the sheet-like patch having a solution or gel in which carbon dioxide is dissolved include a sheet impregnated with a carbon dioxide-dissolved liquid, a carbon dioxide-dissolved sheet-like gel, and a sheet coated with a carbon dioxide-dissolved gel.

In the present invention, from the viewpoint of obtaining a blood circulation promoting effect when applied to the skin, carbon dioxide (CO ₂ ) needs to be dissolved in the liquid or gel of the sheet-like patch (A). Further, since carbon dioxide becomes carbonate (CO ₃ ²⁻ ) under alkaline conditions, the pH of the (A) sheet-like patch solution or gel is 3.5 to 6.5, preferably Is 5.0 to 6.5. The water content of the liquid or gel is preferably 2% by mass or more. A more preferable water content is 2 to 99.5% by mass, a still more preferable water content is 10 to 99.5% by mass, and a particularly preferable water content is 60 to 99.5% by mass.

  (A) The dissolved carbon dioxide concentration in the sheet-like patch solution or gel needs to be 100 to 3,000 ppm (at 25 ° C.) in view of the balance between the blood circulation promoting effect and the pressure resistance of the packaging pillow. Yes, 100 to 2,000 ppm, more preferably 500 to 2,000 ppm, and particularly preferably 800 to 1,800 ppm.

In the sheet material for body sticking of the present invention, the ratio of the weight including the sheet coated or impregnated with the liquid or gel to the volume calculated from the inner surface area of the packaging pillow (denoted as filling ratio) is 0. .1 to 40%. Here, the volume calculated from the inner surface area of the packaging pillow is defined as the volume of a cube that can be taken from the inner surface area. In other words, the surface area S of the cube is 6 times the square of X and the volume is the cube of X when the side is Xcm, and is obtained by 3/2 of (S / 6). With respect to this volume (the cube of X), the upper limit of the filling ratio of the sheet-like patch liquid or gel to be enclosed is that the sheet-like patch has a high concentration of carbon dioxide during storage and transportation. In order to dissolve, 40% or less is preferable, and the lower limit is preferably 0.1% or more in terms of efficient space utilization of packaging pillows and cost reduction in storage / transport and production. That is, when the liquid or gel is filled so as to have a filling ratio of more than 40%, when the carbon dioxide gas is post-filled, the equilibrium dissolved amount of carbon dioxide in the contents is lower than the saturation concentration of carbon dioxide, and the high concentration during use is high. Carbon dioxide cannot be supplied. In addition, when carbon dioxide is dissolved in a liquid or gel after being dissolved in a high concentration, when sealed (sealed) together with a gas other than carbon dioxide in the packaging pillow, the carbon dioxide is vaporized into the packaging pillow in the same manner, Or the carbon dioxide concentration in a gel falls more. For this reason, it is necessary to expel the gas and seal it so that there is no space in the packaging pillow, or to refill it with carbon dioxide and seal it tightly. However, when the filling ratio is more than 40%, in addition to the liquid or gel, carbon dioxide gas is refilled again and sealed, for example, at 15 to 25 ° C, the packaging pillow is being transported and stored at 40 to 60 ° C. In the temperature change encountered, the internal pressure increases due to the volatilization of carbon dioxide gas, and packaging materials that can be used near normal pressure, such as packaging pillows, are not suitable because there is a risk of abnormal expansion or rupture.
Conventionally, encapsulating carbon dioxide in a package has been widely performed in the food industry due to its bacteriostatic effect, but when the content contains moisture, carbon dioxide is contained in the content from room temperature to low temperature. A mixed gas such as nitrogen gas has been used because it dissolves in water and shrinks the packaging container and adversely affects (collapses) the contents. Assuming that carbon dioxide is dissolved in the contents as in the present invention, there is no example controlled to maintain the volume within a certain range in consideration of the volume ratio (functionality / food packaging technology handbook, supervision) Koji Kondo and Rio Yokoyama, published by Science Forum).
On the other hand, when a liquid or gel is enclosed at a volume ratio of less than 0.1%, the amount of liquid or gel relative to the packaging pillow will be very small, and the proportion of space in transportation and storage will be too large to circulate as a product. It will be difficult. Therefore, the filling ratio of the liquid or gel to be sealed is 0.1 to 40%, preferably 0.5 to 35%, more preferably 0.5 to 25%, and further preferably 1 to 10%. It is desirable to enclose as it is. Furthermore, the preferable range of the volume ratio of the liquid or gel depending on the packaging form is that when a four-side seal is used and it is desired to circulate with the thinest possible packaging pillow, the volume ratio of the liquid or gel is preferably 1 to 20%, as shown in FIG. In the case of having a thickness such as a gusset packaging that encloses a tray or a three-sided seal on the back, a range of 0.1 to 10% is preferable.

  (A) The liquid or gel of the sheet-like patch preferably contains an oil that is liquid at 25 ° C. from the viewpoint of dissolving carbon dioxide at a high concentration. This is preferable because a liquid hydrophobic substance dissolves about 3 to 6 times as much carbon dioxide as water, and a liquid oil that is incompatible with water is dispersed in water as an emulsion to maintain this solubility characteristic. And dispersed in the liquid or gel. Examples of the oil include long chain hydrocarbons, higher fatty acids, higher fatty acid esters, higher alcohols, silicones, and fluorocarbons. As long-chain hydrocarbons, liquid paraffin is preferred, and higher fatty acids, higher fatty acid esters, and higher alcohols include branched fatty acids, unsaturated fatty acids, branched fatty acid esters, unsaturated fatty acid esters, branched fatty alcohols, and unsaturated fatty alcohols. It is preferable because it exhibits a liquid state, and oils such as jojoba oil, olive oil, castor oil, mink oil, macadamian nut oil, and unsaturated fatty acid derivatives such as isopropyl myristate and diglyceryl diisostearate are preferable. As silicones, alkyl-modified silicone such as dimethylstearyl polysiloxane, highly polymerized methyl polysiloxane, cross-linked methyl polysiloxane, fluorinated fluorosilicone, and the like are preferable. Furthermore, as fluorocarbons, perfluoropolyethers such as 2- (perfluorohexyl) ethyl 1,3-dimethylbutyl ether, hydrofluoroethers, and the like can be used. These oil agents are preferably contained in the liquid or gel of the sheet-like patch (A) in an amount of 1 to 35% by mass, further 1 to 20% by mass, particularly 1 to 15% by mass.

  (A) Various emulsifiers can be blended in the liquid or gel of the sheet-like patch in order to improve dispersion of various oils and plant extracts and adhesion to the skin. For example, nonionic surfactants such as glycerin monofatty acid ester, polyglycerin monofatty acid ester, sorbitan monofatty acid ester, polyethylene glycol monofatty acid ester, polyoxyethylene sorbitan monofatty acid ester, polyoxyethylene hydrogenated castor oil; Anionic surfactants such as -18 linear or branched fatty acid salts, alkyl phosphate salts having 12 to 18 carbon atoms, N-acyl amino acid salts; cationic interfaces such as stearyltrimethylammonium chloride and distearyldimethylammonium chloride Mention may be made of activators.

  (A) A plant extract can be mix | blended with the liquid or gel of a sheet-like patch. Plant extracts include, for example, licorice extract, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, fat-soluble glycyrrhetinic acids, azulene, guaiazulene, oxon extract, chamomile extract, white birch extract, zebra oyster extract, peach leaf extract, yarrow Anti-inflammatory effects such as extract, Kyary extract, loquat leaf extract, Bodaiju extract eucalyptus extract, and local stimulating effects such as Pepper extract, Dutch mustard, cantalis tincture, salamander extract, peppermint oil, wasabi radish extract Examples include those having an effect on agitation and swelling, such as those possessed, rutin derivatives, Hibamata extract, and sage extract. Antibiotics other than plant extracts, antifungal agents, anti-inflammatory agents, blood circulation promoters, vitamins, humectants, and the like can also be added. Furthermore, mineral powders such as kaolin, sukumite, zinc oxide, titanium oxide and the like can be blended.

  (A) In forming the sheet-like patch into a gel, a water-soluble polymer, a polyhydric alcohol, or the like can be used. Here, as the water-soluble polymer, for example, a crosslinked water-containing gel comprising a polyacrylic acid and a crosslinking agent; cellulose such as polymethacrylic acid, polyacrylamide, polyvinyl alcohol, polyvinylpyrrolidone, carboxymethylcellulose, cellulose derivatives or salts thereof, Examples include gels composed of alginates, pectin and polyvalent cations; water-containing gels using water-soluble polymers such as carrageenan, xanthan gum, gelatin, pullulan, agar, gum arabic, chitosan and derivatives thereof, and water. These water-soluble polymers can be used alone or in combination of two or more, and the gel contains 0.5 to 20% by mass, further 0.5 to 10% by mass, and particularly 0.5 to 5% by mass. preferable.

  Examples of the polyhydric alcohol include glycerin, polyglycerin, propylene glycol, polyethylene glycol, 1,3-butanediol, sorbitol, and xylitol. These polyhydric alcohols can be used alone or in combination of two or more, and are preferably contained in the gel in an amount of 3 to 50% by mass, further 3 to 20% by mass, and particularly 5 to 10% by mass. In addition to these polyols, castor oil, petrolatum, dextrin, and the like can be used for the purpose of adjusting adhesion.

(A) In a sheet-like patch, it is preferable to carry | support said liquid or gel on a sheet | seat base material. As the sheet substrate, woven fabric, non-woven fabric, uneven fabric, synthetic resin film, water-resistant paper and the like can be used, and laminates thereof can also be used. Specifically, synthetic fibers such as nylon, polypropylene, polyester, polyethylene, polystyrene, polyurethane, polyolefin, woven fabric or non-woven fabric such as natural fibers made of silk, cotton, hemp, rayon, collagen, etc .; nylon, polypropylene, polyester, Sheets such as polyethylene and polyurethane; thin film sheets such as pullulan and starch can also be used. The thickness of these sheet base materials is about 0.05 to 2.0 mm, and the surface of the sheet base material may be subjected to a hydrophilic treatment or a hydrophobic treatment. Particularly preferably, the amount of carbon dioxide transdermally supplied can be increased by suppressing the volatilization of carbon dioxide or using a carbon dioxide having a low carbon dioxide permeability. For example, the method using the sheet base material which laminated | stacked the film which suppresses volatilization of a carbon dioxide on one side, such as the said woven fabric or a nonwoven fabric, is preferable. In other words, if the patch that holds the liquid or gel on the sheet base material with low carbon dioxide permeability is suppressed, or if it is applied to the skin as it is, the sheet base surface side opposite to the sticking surface is suppressed. Since volatilization of carbon dioxide can be suppressed, carbon dioxide can be supplied to the skin more continuously. However, in the case of using a manufacturing method in which carbon dioxide is dissolved in the packaging pillow, when the sheet is folded and only the film surface is outside in the pillow, the dissolution rate in the carbon dioxide impregnating solution or gel is remarkably high. Since it is slow, a certain degree of transparency is required. Therefore, the sheet base material has a carbon dioxide permeability of 100,000 cc / m ² · day · atm (25 ° C) (ASTM D-1434) or less, and 5 cc / m ² · day · atm (25 (C) or more is preferable. Particularly preferred are those having properties of 10,000 cc / m ² · day · atm (25 ° C.) or less and 100 cc / m ² · day · atm (25 ° C.) or more. The film constituting the sheet base material having such carbon dioxide permeability of 100,000 cc / m ² · day · atm or less is preferably on the side opposite to the surface of the sheet-like patch that adheres to the skin. Moreover, the form which laminated | stacked the film of carbon dioxide permeability 100,000cc / m < ² > * day * atm (25 degreeC) or less on the nonwoven fabric which carry | supported the liquid or gel which melt | dissolves a carbon dioxide is especially preferable. In addition, the sheet | seat base material which has such a carbon dioxide permeability here should just have this property, and the raw material itself may have a hole in part. Further, where the carbon dioxide permeability ^{100,000cc / m 2 · day · atm} (25 ℃) corresponds to about ^{10,130mL / m 2 · (24hr)} · Mpa.

The film to be laminated is preferably a film that hardly permeates carbon dioxide. Further, it is preferably as thin as possible in terms of feel, and the thickness of the film is 100 μm or less, preferably 50 μm or less, and is preferably 5 μm or more so as not to be broken by the sealing conditions during lamination. Examples of the film material include polyethylene, polypropylene, soft vinyl chloride, polyester, nylon, polyurethane, ethylene / vinyl alcohol copolymer, and ethylene / vinyl acetate copolymer. In addition, a multilayer film such as a multilayer film in which a nylon film or an ethylene vinyl alcohol copolymer (EVOH) is sandwiched between polyethylene and polypropylene films can be used. Further, a film in which aluminum is vapor-deposited on these films, a film in which glass is vapor-deposited, or a film obtained by laminating these films can also be used.
As a method for laminating the film and the nonwoven fabric, a method such as an adhesive or heat fusion can be employed. When laminating thin films, for example, by using an adhesive or using a multilayer film in which high heat-resistant nylon is sandwiched between polyethylene films with high heat-fusing properties, fine tear holes are not generated during lamination. And can be heat-sealed without holes.

  (A) The sheet-like patch is sealed in the packaging pillow together with (B) carbon dioxide. (A) The carbon dioxide is dissolved in the solution or gel of the sheet-like patch, and the carbon dioxide is dissolved. Is necessary to maintain in. At this time, carbon dioxide is 50% by mass or more, preferably 70% by mass or more, particularly preferably 95% by mass or more in the gas in the packaging pillow, in that the dissolved carbon dioxide concentration in the liquid or gel is maintained. preferable. In the above-mentioned Functionality / Food Packaging Technology Handbook, when the contents contain moisture, it is generally considered that not only carbon dioxide but also nitrogen gas is mixed and the carbon dioxide concentration is preferably 20 to 30% by mass. ing. Although it depends on the type of contents, the concentration is 70% by mass or less. In the present invention, the gas other than carbon dioxide is not particularly limited, but for example, air, nitrogen gas and the like are preferable. The pressure of the gas in the packaging pillow is preferably 0.8 to 2.0 atm, more preferably 0.9 to 1.5 atm, particularly 0.9 to 1.2 atm at 25 ° C.

The packaging pillow must be carbon dioxide poorly permeable. Here, “impermeable” means that the carbon dioxide permeability is 50 cc / m ² · day · atm (ASTM D-1434) or less, preferably non-permeable. Preferable materials are those having heat-sealing properties, specifically, a laminate film laminated with an aluminum foil, a laminate film having an aluminum deposited layer, a polyvinylidene chloride film, a laminate film containing a polyvinylidene chloride layer, and the like. It is done. The form of the packaging pillow is preferably a flat bag or a gusset. For the purpose of holding a gel-only sheet or the like, a method such as using a tray made of PET or the like and storing it in a bag made of the above-mentioned carbon dioxide poorly permeable film can also be used.

  In addition, at 25 ° C., the packaging pillow preferably maintains a volume that maintains a filling ratio of 0.5 to 35%, and further 1 to 25% with respect to the volume calculated from the inner surface area. In the case of a gas that does not dissolve in a conventional aqueous solution, such as nitrogen gas, the amount of temperature expansion is small. However, as described above, when carbon dioxide is dissolved in a saturated state in the liquid or gel, it dissolves as the temperature rises. Volatilization is not possible and the space volume may swell up to about twice. For this reason, the packaging pillow preferably maintains a volume that maintains a filling ratio of 1 to 10% at 25 ° C. with respect to the volume calculated from the inner surface area.

  The sheet material for body sticking of the present invention can be produced by, for example, a method in which a sheet-like patch containing a liquid or gel is placed in a packaging pillow, and then the gas in the pillow is replaced with carbon dioxide. Also, carbon dioxide is dissolved in the liquid or gel during or after the formation of the sheet-like patch, and the obtained sheet-like patch is placed in the packaging pillow, and the gas in the pillow is removed or the gas in the pillow is further removed. It can also be produced by a method of exchanging with carbon dioxide. Thus, by adopting a method in which the gas in the pillow is exchanged with carbon dioxide under normal pressure and carbon dioxide is dissolved in the sheet-like patch, an adjustment tank for adjusting a high-concentration carbon dioxide-dissolved liquid or gel, There is an advantage that the equipment for filling the pillow is not required in a state where carbon does not leak. In particular, when a sheet is prepared by coating a gel with a high concentration of carbon dioxide dissolved with a device such as a rotor, it is necessary to provide a facility for sealing the surrounding atmosphere so that carbon dioxide does not evaporate. The load can be reduced. Furthermore, after impregnating and / or coating a sheet with a high-concentration carbon dioxide-dissolved solution or gel, a sheet base material that suppresses the volatilization of carbon dioxide is overlaid, and then the sheet can be manufactured by filling the packaging pillow. As a particularly preferred form, a liquid or gel sheet is placed in a pillow at 25 ° C. so that the filling ratio is 10% or less, and an appropriate amount of carbon dioxide (preferably with a long substitution time and final carbon dioxide). The gas volume is 10% or less of the cubic volume of the pillow), and the method of dissolving carbon dioxide in the liquid or gel can reduce the volume in production and distribution, and the carbon dioxide is saturated and dissolved in the liquid or gel. It is also preferable from the viewpoint of making it. Of course, when filling the carbon dioxide into the pillow, it may be performed not under normal pressure but under pressure, and it is possible to use a method such as sealing with dry ice flakes or powder instead of a gas form.

  The sheet | seat material for body sticking of this invention can be conveniently used by taking out a sheet-like patch from a packaging pillow, and affixing it on skin.

Experimental Example 1 and Experimental Example 2

The above composition is applied onto a low density polyethylene sheet (thickness: 20 μm; carbon dioxide permeability: about 42,000 cc / m ² · day · atm) so as to be 2 mm thick, 40 mm long and 80 mm wide. A gelled sample a (FIG. 2) and a sample b (FIG. 3) placed in a PET tray were prepared so as not to collapse the gelled one.

Each filled with an aluminum pillow and filled with carbon dioxide (Examples 1 and 4), filled with a mixture of carbon dioxide and nitrogen (Examples 2, 3, 5, 6), filled with nitrogen only (Comparative Examples 1 and 2) were prepared and the blood flow promoting effect was measured. Each sample was stored in a pillow for one week from gas filling to blood flow measurement, and carbon dioxide was dissolved in the gel, and then the above measurement experiment was performed.
The mixed gas of carbon dioxide and nitrogen was filled in a separate container with the mixing ratio adjusted from the filling pressure and weight. The conditions of skin flushing and blood flow measurement are as follows.

<Skin flushing degree>
A: It becomes clear red and the pasted boundary can be clearly seen.
○: It turns red, and the pasting boundary can be clearly seen.
Δ: It turns red, but the boundary is unclear.
-: No flushing of the skin is observed.

<Measurement of blood flow>
After acclimatization for 30 minutes in a constant temperature room at 25 ° C., the blood flow in the forearm is measured for 30 seconds with a Doppler blood flow meter (BIOMEDICAL SCIENCE Co., LTD LASER FLOWMETER KB-201), and the average of the values is measured. As 100, each sheet was affixed to the same part, and after the holding time, the sheet was peeled off, and the blood flow volume at the part was measured and expressed as a relative value. The results are shown as relative values of blood flow after holding the forearm skin blood flow before application of the sheet as 100 (Table 2 and Table 3).
Note that each measurement was repeated three times.
<Measurement of carbon dioxide>
Measurement was performed using a carbon dioxide electrode (electrode model 9502 BN; Thermo Orion and portable pH / ion meter model 290A; ORION). Place the sample sheet on an aluminum flat plate at 25 ° C, and after a certain holding time (2, 5, 15, 20 minutes), move it to a covered bottle containing an alkaline solution. After being dissolved, carbon dioxide generated by returning to acidity with an acidic buffer solution (pH 4.5) was measured using the above electrode. The 0 time was measured after being opened and transferred directly to a bottle with a lid containing an alkaline solution.

  When a sheet filled with only nitrogen in a pillow was affixed to the forearm, blood flow in the skin decreased in both Comparative Example 1 and Comparative Example 2. On the other hand, when a sheet filled in a pillow with an increased amount of carbon dioxide was applied, an increase in blood flow was observed, and Examples 1, 2, and 3 of Experimental Example 1 in which the gel was covered with a polyethylene film , Both of the sustainability of blood flow promotion was higher than those of Examples 4, 5, and 6.

Experimental example 3
A PET / rayon nonwoven fabric (basis weight 90 g / m ² ) laminated with a low-density polyethylene film (thickness: 20 μm; carbon dioxide permeability: about 42,000 cc / m ² · day · atm) (Example 7) And a laminated nylon film (thickness: 20 μm; carbon dioxide permeability: about 200 cc / m ² · day · atm) laminated on the same non-woven fabric (Example 8), each adjusted to 30 mm × 40 mm, and a lotion composition 1 (pH 4.8) was impregnated, and carbon dioxide was filled in each of the aluminum pillows in the same manner as in Example 1. Moreover, what filled nitrogen instead of the carbon dioxide in Example 8 (comparative example 3) was also prepared. After storing each for 1 week, the lotion-impregnated sheet was applied to the forearm for 3 minutes or 20 minutes, and the skin condition was observed to confirm the effect of promoting blood flow. As a result, in each of Examples 7 and 8, flushing of the skin was observed, and it was suggested that the nylon film was significantly more flushed with the carbon than the polyethylene film, and the volatilization of carbon dioxide was suppressed.

Experimental Example 4
A low density polyethylene film (thickness: 20 μm; carbon dioxide permeability: about 42,000 cc / m ² · day · atm) was laminated on a nonwoven fabric made of PET / polyethylene / rayon (basis weight 90 g / m ² ) by heat sealing. (Example 9), and the same nonwoven fabric laminated with polyethylene / nylon / polyethylene multilayer film (thickness: 12 μm; carbon dioxide permeability: about 500 cc / m ² · day · atm) by thermal fusion (Example 10) ) Each was adjusted to 30 mm × 40 mm, impregnated with lotion composition 1 (pH 4.8), and carbon dioxide was filled in each of the aluminum pillows as in Example 1. Moreover, what filled nitrogen instead of the carbon dioxide in Example 10 (comparative example 4) was also prepared. After storing each for 1 week, the lotion-impregnated sheet was applied to the forearm for 3 minutes or 20 minutes, and the skin condition was observed to confirm the effect of promoting blood flow. As a result, in each of Examples 9 and 10, flushing of the skin was observed, and it was suggested that the polyethylene / nylon / polyethylene multilayer film had a marked skin flushing and suppressed carbon dioxide volatilization than the polyethylene film.

Experimental Example 5
A sheet of the following gel composition 2 was prepared in the same manner as in Experimental Example 1, and the pillow was filled with 100% carbon dioxide (Example 11) and filled with 100% nitrogen (Comparative Example 5). Was applied to both lower eyelids for 10 minutes every night, and the effect was evaluated.
Evaluation was performed after use for 2 days and after use for 10 days.

  Thereby, when using this invention sheet | seat material containing carbon dioxide, it turned out that a skin symptom improves significantly.

Experimental Example 6
As in Experimental Example 2, gel sheets with different thicknesses were prepared (Examples 12, 13, 14 and Comparative Example 6), placed in a PET container, sealed in an aluminum pillow package with an inner surface area of 100 cm ² , and the voids were carbon dioxide. Sealed after replacement. After storing at 20 ° C. for one week, the carbon dioxide concentration of the sheet was measured.

  Thereby, it can be seen that the dissolved amount of carbon dioxide gas is preferably 35% or less, more preferably 25% or less.

It is a figure which shows the cross-sectional explanatory drawing of this invention body sticking sheet | seat material. It is a figure which shows the form of the gel (sample a) formed on the polyethylene sheet base material. It is a figure which shows the state which preserve | saved the sample b which formed the gel in the sheet form in the tray.

Explanation of symbols

(A): Sheet patch (B): Carbon dioxide (C): Carbon dioxide poorly permeable packaging pillow

Claims (7)

A body made by sealing a sheet-like patch together with carbon dioxide by placing a sheet-like patch containing a liquid or gel in a carbon dioxide-impermeable packaging pillow and replacing the gas in the pillow with carbon dioxide. A sheet material for sticking, which is a sheet-like patch having a solution or gel having a pH of 3.5 to 6.5 in which 100 to 3,000 ppm of carbon dioxide is dissolved at 25 ° C., and a packaging pillow A body sticking sheet material, wherein a filling ratio of the liquid or gel with respect to the volume calculated from the inner surface area is 0.5 to 25 %. The body sticking sheet material according to claim 1, wherein the pressure of the gas in the packaging pillow is 0.8 to 2.0 atm at 25 ° C. 3. The body patch according to claim 1 or 2, wherein the sheet-like patch has a sheet base material having a carbon dioxide permeability of 100,000 cc / m ² · day · atm or less on the opposite side to the surface adhering to the skin. Sheet material. The sheet-like patch is obtained by laminating a carbon dioxide permeable film or a film having a carbon dioxide permeability of 100,000 cc / m ² · day · atm (25 ° C) or less on a nonwoven fabric carrying a solution or gel in which carbon dioxide is dissolved. The sheet | seat material for body sticking of any one of -3 . The sheet | seat for body sticking of any one of Claims 1-4 which puts the sheet-like patch containing a liquid or a gel in the packaging pillow of a carbon dioxide poor permeability, and replace | exchanges the gas in a pillow for carbon dioxide. Method of manufacturing the material. Place a sheet-like patch containing a liquid or gel in a carbon dioxide-impermeable packaging pillow, and replace the gas in the pillow with carbon dioxide to dissolve 100-3,000 ppm of carbon dioxide at 25 ° C. The sheet-like patch having a liquid or gel having a pH of 3.5 to 6.5 is adjusted so that the filling ratio of the liquid or gel to the volume calculated from the inner surface area of the packaging pillow is 0.5 to 25 %. A packaging pillow filled with carbon dioxide and sealed. The packaging pillow according to claim 6, wherein the sheet-like body patch has a sheet base material having a gas permeability of 100,000 cc / m ² · day · atm or less on a side opposite to a surface adhered to the skin.