JP6358540B2 - Manufacturing method of patch and patch - Google Patents

Description

Detailed Description of the Invention

  The present invention relates to a patch and a method for producing the patch, which exhibit effects such as cooling sensation effect, warm sensation effect, cooling effect, analgesic effect, anti-inflammatory effect, or other pharmacological effects by being applied to the human body.

Instead of ice pillows and ice packs for the heat generation of the human body, various cooling patches comprising a water-containing gel composition mainly containing a water-containing water-soluble polymer are used as a cooling agent for sticking human bodies with excellent portability and adhesiveness. Proposed.
In addition, a hydrogel composition containing a hydrous water-soluble polymer contains a medicinal component such as an analgesic component or an anti-inflammatory component, and when applied to the human body, it acts transcutaneously and has an effect corresponding to the medicinal component. Various medicinal patches have been proposed.
In addition, it contains a medicinal component such as an analgesic component and an anti-inflammatory component in an elastic non-aqueous composition such as a non-aqueous composition, synthetic rubber, and natural rubber that does not contain water, and is transdermally applied to a human body. Various medicinal patches have been proposed that act to exert an effect corresponding to the medicinal component.

  For example, in Japanese Patent Application Laid-Open No. 2000-107219 (Patent Document 1), a water-holding base material made of a water-soluble polymer and containing 40% by weight or more of water, and dispersed and held in the water-holding base material. A gel for keeping cold and moisturizing, at least a part of which is made of fibers having hydrophilicity and at least a part of the fibers exposed on the surface of the water-retaining base material, and a large amount of water is retained in the water-retaining base material. It has excellent moisture retention ability, and moisture can easily move inside the base material due to the fibers, and the evaporation of moisture from the water retention base material to the outside can easily occur due to these fibers. Is disclosed.

  JP-A-2004-298474 (Patent Document 2) discloses that (A) polyacrylic acid and / or a salt thereof on the surface having protrusions of a support provided with a plurality of protrusions on one side of an elastic sheet ( B) A patch obtained by coating a hydrous gel containing a cross-linking agent, which exhibits an excellent acupressure effect and provides a high blood flow improvement / treatment effect in the affected area. Moreover, since the hydrogel layer which has flexibility and elasticity becomes a cushion and does not feel sharp pain due to the protrusions, an effect of providing a comfortable feeling of use for a long time is disclosed.

  Japanese Patent Application Laid-Open No. 2004-231577 (Patent Document 3) carries a sustained release of a functional component such as an aroma oil or a pharmacologically active substance in a water-retaining gel containing at least a water-soluble polymer, moisture and a functional component. When the pad material in which gel particles are dispersed and the pad material using the water retention gel is continuously applied to the human body, the substantial sensory effect and the sensory sensory effect due to the pad material gradually decrease. The effect which suppresses this and has a sufficient sensory effect over a long time is disclosed.

  In JP-A-2003-183156 (Patent Document 4), in a patch for external use in which a paste layer is provided on a support, the paste composition forming the paste layer is a non-aqueous base, indomethacin or the like. It is disclosed that it contains a medicinal component and polyethylene glycol, and has the effect of suppressing skin damage while maintaining the adhesiveness and feeling of use of the patch well.

  Japanese Patent Laid-Open No. 2001-47559 (Patent Document 5) discloses an external patch having a support and a drug holding layer coated on the support, wherein the drug holding layer is a water-soluble polymer. Adhesive gel base containing substances, cross-linking agent, water, and water retention agent as essential ingredients, tetracaine, procaine, dibucaine, lidocaine, benzocaine, xylocaine, or pharmaceutically acceptable salt compounds as medicinal ingredients And a non-steroidal anti-inflammatory agent comprising a compound of ketoprofen, piroxicam, felbinac, bufexamac, suprofen, flurbiprofen, diclofenac, ibuprofen, or a pharmaceutically acceptable salt thereof. An external patch comprising a drug-containing base, from rheumatoid arthritis, osteoarthritis, and low back pain Disclosed is an external patch that is an analgesic agent for pain accompanied by inflammation selected from the group that can improve the analgesic effect of pain associated with inflammation such as rheumatoid arthritis, osteoarthritis, and low back pain. Has been.

  Japanese Patent Application Laid-Open No. 2001-64161 (patent document 6) discloses a patch composed of a support body and a plaster part, which has a plaster part, indomethacin, ketoprofen, flurbiprofen, felbinac, diclofenac, or cromoglyc. A patch containing a poorly water-soluble drug such as acid, which peels off and turns over, and the release liner on the surface of the plaster is easy to peel off, and can be easily applied to the shoulder, waist, etc. Has an effect of excellent usability not to remain on the skin surface.

  Japanese Patent Application Laid-Open No. 2003-116903 (Patent Document 7) includes a belt-shaped sheet supply / conveying means for supplying and transporting a belt-shaped sheet in which a plurality of gel composition filling recesses are formed, and includes at least a water-soluble polymer and water. The gel composition prepared so as to be gelled is stored, and a storage tank having a delivery port for sending the gel composition onto the belt-like sheet in the lower part, and a movement of the belt-like sheet installed at the feed-out port by conveyance of the belt-like sheet At the same time, the gel composition having the gel composition filling means for filling the blister-type container with the gel composition filling means for pushing the gel composition fed from the delivery port onto the belt-like sheet into each recess of the belt-like sheet and filling it. An agent filling device is disclosed that is capable of automatically filling a gel composition without containing air in a blister type container.

  In JP 2007-190325 A (Patent Document 8), a water-insoluble adhesive provided on the opposite surface of a holding sheet on which a water-containing gel body having a high water content and a low adhesion was formed was used. In a portable cooling sheet comprising a cooling sheet having a release sheet attached to an adhesive layer in a peelable manner and a blister-type storage container provided with a flange around an accommodation recess, the release sheet in the cooling sheet is It is formed larger than the holding sheet and the water-containing gel body, and the water-containing gel body and the holding sheet are accommodated in the blister-type housing recess so that the water-containing gel body in the cooling sheet is positioned on the bottom side of the housing recess. And a portable cooling sheet in which the closing member is attached to the collar portion of the blister-type storage container so as to cover the release sheet protruding from the housing recess to the collar portion side, and has high cooling. Fruit can be maintained long time, the effect of cooling the sheet is easily obtained which can be properly adhered to application site of the body so as not easily peeled off is disclosed.

JP 2000-107219 A JP 2004-298474 A JP 2004-231577 A JP 2003-183156 A Table 2001-47559 JP 2001-64161 A JP 2003-116903 A JP 2007-190325 A

In the above-mentioned conventional patch, generally, the active composition in a fluid state such as a hydrogel composition or a plaster composition is laminated on the surface of a holding member made of porous fibers such as a nonwoven fabric, and then the laminated active composition The patch is manufactured by a manufacturing method including a step of processing the gel into a soft or soft state that does not flow. Thus, in order to form the thickness, area, shape, laminating position, etc. of the patch to be laminated with high accuracy because it is a production method in which the active composition in a fluid state is directly laminated on the surface of the holding member. It requires a complicated manufacturing process.
In addition, in order to form a flexible effect composition into a desired shape, when a flexible effect composition is cut into a desired shape using a normal press cutting blade mold, the residue of the flexible effect composition after the cutting operation is In a mass production process that adheres to the cutting edge and, as a result, performs repeated cutting, an operation for cleaning and removing the attached matter on the cutting edge of the pressing blade type is required.

  The present invention solves the above-described problems, and provides a method for producing a patch and a patch that can form a flexible effect composition on the surface of a holding member with high precision in the thickness, area, shape, lamination position, and the like. I will provide a. In addition, the present invention solves the above-mentioned problems, and when a flexible effect composition is cut into a desired shape using a normal press cutting blade mold, the residue of the flexible effect composition after the cutting operation is a cutting edge of the press cutting blade type. A method for producing a patch and a patch capable of suppressing adhesion to the skin are provided.

The method for producing a patch of the present invention comprises at least a flexible effect composition containing a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition. The flexible effect composition has a flowable state at a first flow temperature, is capable of being cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed at the time of cutting. It has a non-deformation state and has a soft state with no fluidity at a third non-flow softness temperature where the second cooling non-deformation temperature is raised, and the softness-effective composition is at the second cooling non-deformation temperature. A method of manufacturing a patch, which is manufactured by a process including a process of being formed into a predetermined shape in a cooled state, wherein (A) a holding member supplying process for supplying a holding member, (B) the first Flow at flow temperature A flow-efficiency composition raw material preparation step for preparing a flow-efficiency composition raw material having a movable flowable state; A cooling predetermined shape forming step of forming a cooling non-deformation efficacy composition in a state, and then cutting the cooling non-deformation efficacy composition into a predetermined shape to prepare a cut cooling non-deformation efficacy composition, (D) the holding member A non-deformable effect composition laminating step for preparing a holding member / cut cooling non-deformation effect composition laminate, and (E) the holding member / cut non-deformation effect composition The deformable effect composition laminate is heated to the third non-flowing flexible temperature, and the cutting cooling non-deformable effect composition is changed from a cooling non-deformable state to a flexible state having no fluidity, and The softening composition By adhering to the support member, the flexible efficacy composition characterized in that it comprises the adhesion laminating step, efficacy compositions softening preparing the holding member, flexibly, efficacy compositions laminate structure prepared by adhering to the holding member.

Another method for producing a patch of the present invention includes a flexible effect composition having at least a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition And the flexible effect composition has a flowable state capable of flowing at a first flow temperature, is capable of being cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed at the time of cutting. Having a non-deformable state and having a soft state with no fluidity at a third non-flowing soft temperature at which the second cooling non-deforming temperature is raised, and the flexible effect composition is the second cooling non-deformation A method of manufacturing a patch, which is manufactured by a process including a process of being formed into a predetermined shape while being cooled to a temperature, wherein (A) a holding member supplying process for supplying a holding member, (B) At the first flow temperature A flow-efficiency composition raw material preparation step for preparing a flow-efficiency composition raw material having a flowable state, and (C) cooling the non-deformation temperature to the second cooling non-deformation temperature at which the flow-effect composition raw material is non-deformed Forming a cooling non-deformation efficacy composition in a deformed state, and then cutting the cooling non-deformation efficacy composition into a plurality of predetermined shapes to prepare a plurality of cut cooling non-deformation efficacy compositions Step (D) The plurality of cutting cooling non-deformation efficacy compositions are laminated and adhered to a predetermined surface region of the holding member to prepare a holding member and a plurality of cutting cooling non-deformation efficacy composition laminated structures. A plurality of cooling non-deformable effect composition layering steps; and (E) the holding member and the plurality of cut cooling non-deformation effect composition layered components are heated to a third non-flowing flexible temperature, The non-deformation state of the non-deformable active composition A flexible effect composition that has been changed to a flexible state and softened is attached to the holding member, and a holding member in which the flexible effect composition in a flexible state adheres to the holding member-a plurality of flexible effect composition laminated compositions It is characterized by comprising an effect composition softening adhesion laminating step to be prepared .

Another method for producing a patch of the present invention includes a flexible effect composition having at least a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition And the flexible effect composition has a flowable state capable of flowing at a first flow temperature, is capable of being cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed at the time of cutting. Having a non-deformable state and having a soft state with no fluidity at a third non-flowing soft temperature at which the second cooling non-deforming temperature is raised, and the flexible effect composition is the second cooling non-deformation A method of manufacturing a patch, which is manufactured by a process including a process of being formed into a predetermined shape while being cooled to a temperature, (A) a holding member supplying process for supplying a holding member, and (B) each other Different composition components A plurality of types of fluid effect composition raw material preparation steps for preparing a plurality of types of fluid effect composition raw materials, Forming a plurality of types of cooling non-deformable efficacy compositions in a non-deformed state, and then cutting the plurality of types of cooling non-deformation efficacy compositions into a plurality of predetermined shapes, thereby providing a plurality of types of cooling non-deformation efficacy compositions. A plurality of types of cut cooling non-deformation forming effect compositions cut into a predetermined shape for the effect composition, a plurality of cutting cooling predetermined shape forming step, (D) the predetermined surface of the holding member, Multiple types of cutting cooling non-deformation efficacy compositions are sequentially laminated and adhered in multiple layers to prepare a holding member / multiple types of cutting cooling non-deformation efficacy composition laminate composition. Process, And (E) raising the temperature of the holding member / multiple types of cutting cooling non-deformation efficacy composition layered composition to a third non-flowing flexible temperature, and undeforming the plurality of types of cutting cooling non-deformation efficacy composition The flexible effect composition in a flexible state that is in contact with the holding member is joined to the holding member, and a plurality of types of flexible effect compositions are joined together to change the flexible effect in the flexible state. The composition comprises: a holding member joined to the holding member; and an effect composition softening and adhesion laminating step for preparing a plurality of types of flexible effect composition laminated structures .

Another method for producing a patch of the present invention includes a flexible effect composition having at least a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition And the flexible effect composition has a flowable state capable of flowing at a first flow temperature, is capable of being cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed at the time of cutting. Having a non-deformable state and having a soft state with no fluidity at a third non-flowing soft temperature at which the second cooling non-deforming temperature is raised, and the flexible effect composition is the second cooling non-deformation A method of manufacturing a patch, which is manufactured by a process including a process of being formed into a predetermined shape while being cooled to a temperature, (A) a holding member supplying process for supplying a holding member, and (B) each other Different composition components A plurality of types of fluid effect composition raw material preparation steps for preparing a plurality of types of fluid effect composition raw materials, and (C) cooling each of the plurality of types of fluid effect composition raw materials to a second cooling non-deformation temperature at which they are in an undeformed state. Forming a plurality of types of cooling non-deformable efficacy compositions in a non-deformed state, and then cutting the plurality of types of cooling non-deformation efficacy compositions into a plurality of predetermined shapes to obtain a plurality of types of cooling non-deformation compositions. A plurality of types of cut cooling non-deformation effect compositions cut into a predetermined shape for the effect composition, a plurality of cutting cooling predetermined shape forming step, (D) a planar region of a predetermined surface of the holding member; The plurality of types of cutting cooling non-deformation forming effect compositions are positioned at predetermined positions so as to be adjacent to each other in the plane region, and a holding member and a plurality of types of cutting cooling non-deforming effect composition laminated composition are prepared. Multiple types Cutting cooling non-deformation effect composition laminating step, and (E) the holding member / plural types of cutting cooling non-deformation effect composition laminating composition is heated to a third non-flowing flexible temperature to cut the plural types of cutting The cooling non-deformable effect composition is changed from an undeformed state to a flexible state, and a plurality of types of softened flexible effect compositions are bonded to each other in a planar region and bonded to the holding member, so that a plurality of types of flexible effect compositions are combined. A holding member in which an object is bonded to the surface of the holding member, and an effect composition softening and adhesion laminating step for preparing a plurality of types of soft effect composition laminated structures are provided .

Another method for producing a patch of the present invention includes a flexible effect composition having at least a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition And the flexible effect composition has a flowable state capable of flowing at a first flow temperature, is capable of being cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed at the time of cutting. Having a non-deformable state and having a soft state with no fluidity at a third non-flowing soft temperature obtained by raising the second cooling non-deforming temperature, A method of manufacturing a patch, which is manufactured by a process including a process of being formed into a predetermined shape while being cooled to a temperature, wherein (A) a holding member supplying process for supplying a holding member, (B) At the first flow temperature Fluid effect composition raw material preparation step for preparing a fluid effect composition raw material having a fluid state that can be flowed, (AB) laminating the fluid effect composition raw material on the holding member, and holding member / fluid effect composition raw material Fluidity composition laminating step for preparing a layered composition, (ABC) Cooling the holding member / fluidity composition raw material layered composition to a second cooling non-deformation temperature at which the fluidity composition raw material is in an undeformed state. Then, the holding member / cooling non-deformation effect composition in which the non-deformation cooling non-deformation effect composition is formed is prepared, and then the holding member / cooling non-deformation effect composition is cut into a predetermined shape. A cooling predetermined shape forming step of preparing a cutting cooling non-deformation effect composition, and (E) raising the temperature of the holding member-cut cooling non-deformation effect composition laminate to the third non-flowing flexible temperature, Cutting cooling non-deformation effect group A holding member in which a flexible effect composition is attached to the holding member by changing the object from a cooling non-deformed state to a flexible effective composition having no fluidity and attaching the flexible effect composition to the holding member. An effect composition softening adhesion laminating step for preparing a flexible effect composition laminate composition is provided.

Another method for producing a patch of the present invention includes a flexible effect composition having at least a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition And the flexible effect composition has a flowable state capable of flowing at a first flow temperature, is capable of being cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed at the time of cutting. Having a non-deformable state and having a soft state with no fluidity at a third non-flowing soft temperature at which the second cooling non-deforming temperature is raised, and the flexible effect composition is the second cooling non-deformation A method of manufacturing a patch, which is manufactured by a process including a process of being formed into a predetermined shape while being cooled to a temperature, wherein (A) a holding member supplying process for supplying a holding member, (B) At the first flow temperature Fluid effect composition raw material preparation step for preparing a fluid effect composition raw material having a fluid state that can be flowed, (AB) laminating the fluid effect composition raw material on the holding member, and holding member / fluid effect composition raw material Fluid effect composition laminating step for preparing a layered composition, (ABC-a) the holding member / fluid effect composition raw material layered composition, the second cooling non-deformation temperature at which the fluid effect composition raw material is in an undeformed state The holding member / cooling effect composition laminated composition in which the non-deformed state cooling non-deformable effect composition is formed is prepared, and then the holding member / cooling effect composition laminated composition A plurality of cutting cooling predetermined shape forming steps for preparing a plurality of holding members / cutting cooling non-deformation effect composition by cutting into a shape, (Ea) The plurality of holding members / cutting cooling non-deformation effect composition lamination The third non-flowing soft The temperature is raised to a temperature, and the cutting cooling non-deformation effect composition is changed from a cooling non-deformation state to a flexible effect composition having no fluidity, and the flexible effect composition is attached to the holding member, An effect composition softening adhesion laminating step of preparing a plurality of holding members / softening effect composition laminate structure in which the softening effect composition adheres to the holding member.

  Desirably, further, (F) a blister type container supply step for supplying a blister type container having an accommodation recess opened on the upper surface and a gutter formed at the periphery of the recess, and (AF) the recess of the blister type container A holding member disposing step of adjusting the holding member disposing container by disposing the holding member, and (D) through the (B) fluidity effect composition raw material preparing step and the (C) cooling predetermined shape forming step. In the cooling non-deformation effect composition laminating step, the cutting cooling non-deformation effect composition is laminated on the holding member disposed in the recess of the blister type container material to prepare a holding member / cut cooling non-deformation effect composition Then, after the (E) efficacy composition softening adhesion lamination process, it is characterized by the above-mentioned.

  Desirably, it is a manufacturing method of the patch further provided with the peeling protection member peeled at the time of use on the other surface of the said flexible effect composition, Comprising: (Ga) The peeling protection member which supplies the said peeling protection member After the supplying step and (Gb) (D) the cooling non-deformable effect composition laminating step, the release protection member is laminated on the other surface of the cooling non-deformation effect composition, and the holding member / cooling non-deformation is performed. After the peeling member laminating step for preparing the effect composition / peeling protection member laminated structure, or after the (E) efficacy composition softening adhesion laminating step, the peeling protection member is laminated on the other surface of the flexible efficacy composition. And a release member lamination step for preparing a holding member, a flexible effect composition, and a peel protection member laminate composition.

Desirably, it is a manufacturing method of a patch provided with a peeling protection member peeled off at the time of use, and (Ga) a peeling protection member supply process which supplies the above-mentioned peeling protection member, and
(Gb) While installing the peeling protection member in a state of covering the other surface of the holding member / cutting cooling non-deformation effect composition and the blister of the blister type container, the holding member / cutting cooling non-deformation effect In a state where the composition laminate is depressurized so as to be depressurized from the atmospheric pressure, a sealing step of joining the peeling protection member and the blister of the blister type container to thereby prepare a vacuum sealed package It is characterized by providing.

  Desirably, in the (B) fluid effect composition raw material preparation step, the fluid effect composition raw material contains at least water and a water-soluble polymer containing water, and is in a fluid state capable of flowing at the first fluid temperature. And can be cut as the temperature becomes lower than the first flow temperature and becomes non-deformable to the extent that it does not deform at the time of cutting, and is not fluid when processed from the non-deformed state to the third non-flow flexible temperature. It has the property of becoming a hydrous gel-like soft-acting composition.

  Desirably, when applied to the skin of a human body, it has a cooling effect or a cooling effect.

  Desirably, the fluidity composition raw material or the efficacy composition further contains a medicinal component having transdermal absorbability, and exhibits the medicinal effect exhibited by the medicinal component when applied to the skin of a human body. And

  Preferably, the holding member is made of a porous material having a fine uneven surface capable of passing at least one of air, moisture and moisture, and in the (E) active composition softening adhesion laminating step, The cutting cooling non-deformation effect composition changes from an undeformed state to a flexible state, and a part of the softened flexible effect composition adheres to the inside of the unevenness of the fine uneven surface of the holding member, and is in a flexible state. The flexible effect composition is processed so as to adhere to the holding member without being peeled off.

  Preferably, the fluidity-effective composition raw material contains at least water and a water-soluble polymer containing water, and the first flow temperature is about 15 ° C to about 90 ° C at which the fluidity-effective composition raw material can flow. And the second cooling non-deformation temperature is a temperature range of about 5 ° C. or less at which the cooling non-deformation effect composition is not deformed during cutting, and the third non-flow softening temperature is The temperature is about 5 ° C. to about 50 ° C. without fluidity.

The patch of the present invention comprises at least a holding member and a flexible efficacy composition, and the flexible efficacy composition has a plurality of types of flexible efficacy compositions having different composition components, and the plurality of types of flexible efficacy compositions. each flexible efficacy compositions compositions exhibit the different efficacy from each other, each flexible efficacy composition of the plurality of types of flexible efficacy composition will be configured be bonded to a surface of said holding member, said plurality of types Each of the flexible effect compositions of the flexible effect composition contains at least water and a water-soluble polymer, has a flowable state at the first flow temperature, and has a second cooling temperature lower than the first flow temperature. A non-deformable state that can be cut into a predetermined shape at a non-deformation temperature and that is not deformed at the time of cutting. A water-containing gel-like soft and effective composition, wherein the water-soluble polymer is selected from the group consisting of at least polyacrylic acid, a polyacrylic acid neutralized product, polyacrylic acid salts, and a carboxyvinyl polymer. The surface of the holding member at the third non-flowing flexible temperature, having at least one water-soluble polymer, having a predetermined shape cut at the second cooling non-deformation temperature and having an undeformed state that does not deform when cut. The respective hydrogel soft-effect compositions having a predetermined shape joined to each other in the planar region are arranged in the planar region on the surface of the holding member and joined to each other. .

  Desirably, the plurality of types of soft-effect compositions exhibit a cooling effect when applied to at least the skin of a human body.

Desirably, the plurality of types of soft-effect compositions contain at least a transdermally absorbable medicinal ingredient,
When applied to the skin of a human body, the medicinal properties of the medicinal component are exhibited.

  Preferably, the plurality of types of soft-effect compositions are at least a first soft-action composition containing a transdermally absorbable medicinal ingredient, and the first soft-action composition when applied to the human skin. It is characterized by comprising a flexible effect composition that exhibits strong adhesive strength.

(Effect a)
According to the method for producing a patch of the present invention, a flexible effect composition laminated on a holding member can be formed with high accuracy in a desired thickness, area, shape, weight, lamination position, and the like The proportion can be formed stably with high accuracy without fluctuation in the patch product, and as a result, the yield of good products can be remarkably improved, and the patch having the desired quality can be stably mass-produced. Significant cost reduction is possible.
Furthermore, when cutting a flexible effect composition into a desired shape using an ordinary press cutting blade mold, the amount of deposits such as residues of the flexible effect composition adhering to the cutting edge of the press cutting blade mold after the cutting operation is suppressed. it can.

(Effect B)
A method for producing a patch comprising at least a flexible efficacy composition that has a plurality of composition components and exhibits efficacy, and a holding member that is bonded to one surface of the efficacy composition and holds the efficacy composition, The flexible effect composition has a flowable state at a first flow temperature, and can be cut at a second cooling non-deformation temperature lower than the first flow temperature and is not deformed at the time of cutting. And having a flexible state with no fluidity at a third non-flowing flexible temperature obtained by raising the second cooling non-deformation temperature, the flexible effect composition being cooled to the second cooling non-deformation temperature In the desired thickness, area, shape, weight, laminating position, etc., the flexible effect composition to be laminated on the holding member by the method for producing a patch comprising the step of being processed and formed into a predetermined shape in Formed with high accuracy In addition, the composition ratio of the composition can be stably and mass-produced without changing in the patch product, and as a result, the yield of good products can be remarkably improved and a patch having a desired quality can be obtained. It can be mass-produced stably and the cost can be reduced.
Furthermore, when cutting a flexible effect composition into a desired shape using an ordinary press cutting blade mold, the amount of deposits such as residues of the flexible effect composition adhering to the cutting edge of the press cutting blade mold after the cutting operation is suppressed. As a result, the patch having the desired quality can be stably mass-produced, and the cost can be reduced.

(Effect C)
(C) The fluidity-effective composition raw material is cooled to a second cooling non-deformation temperature at which the fluidity-effective composition raw material is brought into an undeformed state to form an undeformed cooled non-deformable effect composition. The patch manufacturing method with a cooling predetermined shape forming process that cuts into a shape to prepare a cut cooling non-deformable effect composition prevents deformation at the time of cutting and enables easy and high-precision cutting into a desired shape. Thus, a patch that remarkably exhibits the effect (b) is obtained.

(Effect D)
(C) The fluidity-effective composition raw material is cooled to a second cooling non-deformation temperature at which the fluidity-effective composition raw material is brought into an undeformed state to form an undeformed cooled non-deformable effect composition. A plurality of flexible effect compositions having a desired thickness can be obtained by a method for producing a patch having a cooling predetermined shape forming step of preparing a plurality of cut cooling non-deformation effect compositions by cutting into a predetermined shape. In addition, each flexible effect composition can be formed with high accuracy in terms of area, shape, weight, lamination position, etc., and the composition component content can be stably and mass-produced without fluctuation in patch products As a result, the yield of non-defective products can be remarkably improved, and a patch having a desired quality can be stably mass-produced, and the cost can be reduced.

(Effect)
Multiple types of flow-effect composition raw materials having different composition components are cooled to a second cooling non-deformation temperature at which they are in a non-deformed state, cut into a predetermined shape, and a plurality of types of cutting cooling non-deformation effects formed into a predetermined shape By a method for producing a patch comprising a step of laminating a composition on a holding member in multiple layers, a plurality of types of flexible-effect compositions having different composition components can be obtained in a desired thickness, area, shape, weight, lamination position, etc. Various types of flexible-effect compositions can be formed with high precision, and the composition ratio of the composition can be stably and mass-produced without fluctuation in the patch product, resulting in a significant improvement in the yield of good products. It is possible to stably mass-produce a patch having a desired quality. For example, a first shape flexible effect composition having a strong adhesive force is laminated on the surface of the holding member, and a second shape that exerts a cooling effect or an analgesic effect on the inner region of the surface of the first shape flexible effect composition. By laminating and forming the flexible effect composition, a patch having a strong adhesive force in the surroundings and having a cooling effect or an analgesic effect in the inner region can be obtained.

(Effect)
Multiple types of flow-effect composition raw materials having different composition components are cooled to a second cooling non-deformation temperature at which they are in a non-deformed state, cut into a predetermined shape, and a plurality of types of cutting cooling non-deformation effects formed into a predetermined shape By a method for producing a patch comprising a step of attaching the composition to a planar region of a holding member, a plurality of types of flexible effect compositions having different composition components can be obtained in a desired thickness, area, shape, weight, lamination position, etc. It is possible to form multiple types of flexible-effect compositions with high accuracy, and the composition component ratios can be stably and mass-produced with high accuracy without fluctuation in the patch product. It is possible to easily form a patch having regions of different compositional components on the surface, and as a result, a patch having a desired quality can be stably mass-produced. For example, a patch region exhibiting a cooling effect, a patch region exhibiting an analgesic effect, a patch region exhibiting strong adhesiveness, and the like are alternately formed in the lateral direction of the surface region of the holding member. It is possible to obtain a patch that exhibits its efficacy and has excellent adhesive performance.

(Effect)
Multiple types of flow-effect composition raw materials having different composition components are cooled to a second cooling non-deformation temperature at which they are in a non-deformed state, cut into a predetermined shape, and a plurality of types of cutting cooling non-deformation effects formed into a predetermined shape (A) the step of adhering the composition in the blister-type container in which the housing recess is formed, or (b) the step of sequentially laminating and adhering to the surface of the holding member, By the manufacturing method of the provided patch,
The flexible effect composition laminated on the holding member can be formed with high accuracy in the desired thickness, area, shape, weight, lamination position, etc., and the composition ratio of the composition is not changed in the patch product. The mass production can be stably performed with high accuracy. As a result, the yield of non-defective products can be remarkably improved, and a blister type patch having a desired quality can be mass-produced stably.

(Effect Z)
A blister type container is configured, and a holding member and a plurality of types of cutting cooling non-deformation effect compositions formed in a predetermined shape are arranged in the blister type container, and (Gb) the holding member / cutting cooling non-deformation effect composition The peeling protection member is installed in a state where the other side of the object and the blister of the blister container are covered, and the holding member / cutting cooling non-deformation effect composition laminate is placed in a reduced pressure state from atmospheric pressure. In addition to the above-mentioned effects (effect G), a flexible efficacy composition by vacuum sealing in accordance with the method for producing a patch provided with a sealing step for joining the peel protection member and the blister-type container ridge in a decompressed state The effect of significantly reducing the air bubbles remaining in the object, and the effect of significantly improving the bondability of the holding member and the flexible effect composition when the flexible effect composition enters the voids of the non-woven holding member, In addition, decompression Is prevented oxidation of the flexible efficacy composition to the amount of oxygen in the sealed container is reduced, the adhesive patch can be obtained to achieve the long-term storage are possible excellent storage stability.

(Effect)
In the flow-efficiency composition raw material preparation step, the flow-efficiency composition raw material contains at least water and a water-soluble polymer containing the water, and is in a fluid state capable of flowing at a first flow temperature, which is higher than the first flow temperature. Properties that become a non-deformable hydrous gel-like composition with no fluidity when processed from the non-deformed state to the third non-flowable softening temperature. According to the method for producing a patch having a constitution having the above, a patch constituting the hydrogel soft-acting composition exhibiting the effects (effects i) to (effect h) can be obtained. Furthermore, the hydrogel composition can be freely designed with its gel components and medicinal ingredients, and when the patch is applied to the human body, it has a moderate cooling sensation due to the hydrous ingredients and exhibits a medicinal effect due to the medicinal ingredients. An adhesive is obtained, and a skin-friendly patch that can suppress skin inflammation to a minimum is obtained. In addition, the water-containing gel composition having a relatively high fluidity is cooled and cut into a cooled and non-deformable active composition, and then cut into a predetermined shape to obtain a cooled and non-deformable active composition having a predetermined shape. Furthermore, the disadvantage that the hydrogel composition adheres to the blade mold used at the time of cutting is suppressed, the occurrence of defects during mass production is suppressed, and the productivity is remarkably improved.

(Effect)
In particular, the holding member is composed of a porous material having a fine uneven surface capable of passing at least one of air, moisture, and moisture, and in the effect composition softening adhesion laminating step, cutting cooling non-deformation effect composition As the material changes from a non-deformed state to a flexible state, a part of the softened flexible effect composition adheres in a state where it enters into the unevenness of the fine uneven surface of the holding member, and the flexible effect composition in the flexible state is retained. By the method of manufacturing a patch comprising a process for fixing to a member without being peeled off, the above-mentioned (Effect A) to (Effect No.) effects are exhibited, and the flexible efficacy composition strongly bonded to the holding member A patch comprising the product is obtained.

(Effect O)
In particular, the fluid effect composition raw material or the effect composition is a patch that exhibits excellent cooling effect or cooling sensitivity effect by the method for producing a patch that exhibits cooling effect or cooling effect when applied to the skin of a human body. Is obtained.

(Effect)
In particular, the fluidity composition composition raw material or the efficacy composition further contains a medicinal component having transdermal absorbability, and when applied to the skin of a human body, the manufacture of a patch exhibiting the medicinal effect exhibited by the medicinal component By the method, a patch exhibiting the medicinal effect of the contained efficacy composition is obtained.

(Effect)
In particular, after the (Gb) (D) cooling non-deformable effect composition laminating step, the peeling protective member is laminated on the other surface of the cooling non-deformable effect composition, and the holding member / cooling non-deformable effect composition・ Peeling member lamination process for preparing a peeling protection member laminate structure, or
Peeling to prepare a holding member / flexible efficacy composition / peeling protection member laminated structure by laminating the peeling protection member on the other surface of the flexible efficacy composition after the (E) efficacy composition softening adhesion laminating step By the manufacturing method including the member stacking step, it is possible to manufacture a patch in which the peeling protection member is efficiently stacked on the flexible effect composition, and the productivity is improved.

(Effect a)
The present invention comprises at least a holding member and a flexible effect composition, and the flexible effect composition has a plurality of types of flexible effect compositions having different composition components, and the plurality of types of the flexible effect compositions Each of the flexible effect compositions has different effects, and the plurality of types of flexible effect compositions are formed by laminating the holding member to form a plurality of types of flexible effect compositions having different composition components. A patch formed with high accuracy is obtained in a desired thickness, area, shape, weight, lamination position, and the like. In addition, a patch containing a stable composition component ratio can be obtained without fluctuation in the patch product. In addition, it is easy to design a patch having various effects.

(Effect b)
The above-mentioned (Effect a) is obtained by the patch configured by laminating and joining the flexible effect compositions of the plurality of types of flexible effect compositions to each other in the thickness direction and laminating the holding member. In addition, for example, a second flexible efficacy composition having a strong adhesive force on the surface of the first flexible efficacy composition, for example, by laminating a first shape flexible efficacy composition having a cooling effect or an analgesic efficacy on the surface of the holding member. By laminating and forming, a patch having a strong adhesive force and a cooling effect or an analgesic effect is obtained.

(Effect c)
The above-mentioned (Effect a) is obtained by the patch composed of the plurality of types of the flexible effect compositions that are bonded to each other in a planar region and laminated on the holding member, and further, A patch having regions of different composition components on the surface of one patch can be easily obtained, and a patch having a desired quality can be stably mass-produced. For example, a patch region exhibiting a cooling effect, a patch region exhibiting an analgesic effect, a patch region exhibiting strong adhesiveness, and the like are alternately formed in the lateral direction of the surface region of the holding member. It is possible to obtain a patch that exhibits its efficacy and has excellent adhesive performance.

(Effect d)
Each of the flexible effect compositions of the holding member and the plurality of types of flexible effect compositions is configured in a state of being accommodated in a blister type container provided with a ridge at the periphery of an accommodation recess having an upper surface opened. With such a patch, a patch in which the flexible effect composition laminated on the holding member is formed with high precision in a desired thickness, area, shape, weight, lamination position, and the like can be obtained. In addition, a blister-type patch with stable and excellent medicinal effects can be obtained without changing the proportion of the composition component contained in the patch product.

(Effect e)
The plurality of types of soft-effect compositions contain at least water and a water-soluble polymer containing the water, have a fluid state in which the fluid can flow at the first fluid temperature, and have a second cooling temperature lower than the first fluid temperature. A patch that has a non-deformable state that can be cut at a non-deformation temperature and that does not deform at the time of cutting, and has a non-flowable soft state at the third non-flow soft temperature that is raised from the second cooling non-deformation temperature. Thus, a patch exhibiting the effects (effect d) to (effect d) described above can be obtained, and the hydrogel composition can be freely designed with its gel component and medicinal component, and the patch can be applied to the human body. When applied to a patch, a patch having a moderate cooling sensation due to a water-containing component and a medicinal effect due to a medicinal component is obtained, and a skin-friendly patch that can suppress skin inflammation to a minimum is obtained. In addition, the water-containing gel composition having a relatively high fluidity is cooled and cut into a cooled and non-deformable active composition, and then cut into a predetermined shape to obtain a cooled and non-deformable active composition having a predetermined shape. Furthermore, the disadvantage that the hydrogel composition adheres to the blade mold used at the time of cutting is suppressed, the occurrence of defects during mass production is also suppressed, and the productivity is remarkably improved. In particular, the water-containing gel-like soft-effect composition is preferably a water-containing crosslinked gel-like soft-effect composition or a non-crosslinkable water-containing gel composition.

It is a figure explaining the manufacturing process of the manufacturing method of the patch of one Example of this invention, (A) is process explanatory drawing, (B) is a schematic process schematic diagram. (Embodiment 1) It is a plane schematic diagram which shows the shape of the cutting cooling nondeformation effect composition cut | disconnected by the various shape of one Example of this invention. (Embodiment 1) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 2) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 3) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 4) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 5) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 6) It is a schematic plane schematic diagram which shows arrangement | positioning of the multiple types of soft effect composition of the patch of one Example of this invention. (Embodiment 6) It is a figure explaining the manufacturing process of the manufacturing method of the patch of one Example of this invention, (A) is process explanatory drawing, (B) is a schematic process schematic diagram. (Embodiment 7) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 8) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 9b) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 9c) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 9e) It is a schematic process schematic diagram of the manufacturing method of the patch of one Example of this invention. (Embodiment 9f) It is a schematic diagram which shows one Example of the process of cut | disconnecting the cooling nondeformation effect composition of the manufacturing method of the patch of this invention.

Below, the manufacturing method and patch of the patch of this invention are demonstrated.
The method for producing a patch of the present invention comprises at least a flexible effect composition containing a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the effect composition and holds the effect composition. A method for producing a patch, wherein the flexible effect composition has a flowable state at a first flow temperature and can be cut at a second cooling non-deformation temperature lower than the first flow temperature. And having a non-deformation state that does not deform when cut, and having a soft state without fluidity at a third non-flow soft temperature that has been raised to the second cooling non-deformation temperature, It is manufactured by a process including a process of forming a predetermined shape while being cooled to the second cooling non-deformation temperature.
Thereby, the above-mentioned effects (Effect A) and (Effect B) can be obtained.

(Definition of words / phrases)
The “flowable fluid state” of the flexible effect composition at the first flow temperature is such that the soft effect composition is filled in an approximately 200 ml polystyrene cup-like container and the cup is about 45 degrees. Means a fluidized state having such a property that the flexible effect composition flows out of the container and starts to deform within about 5 seconds when tilted at an angle of.
The “non-deformed state that can be cut and does not deform during cutting” of the flexible effect composition at the second cooling non-deformation temperature is a double-edged shape with a tip edge angle of about 30 degrees and a height of about 5 mm. Means the non-deformed state in which the cooling non-deformable effect composition is cut without flowing and separated into a desired shape when the cooling non-deformation effect composition is cut using the mounted flat plate cutting device. To do.
The “soft state without fluidity” at the third non-flowing softening temperature is a surface of a holding member made of a nonwoven fabric having a flexibility of flexure and air humidity permeability containing a polyethylene terephthalate fiber of about 1 mm thickness and 300 mm square, When the soft and effective composition in which the soft and effective composition is arranged at a thickness of about 3 mm and maintained at an angle of about 45 degrees for 60 seconds, the soft and effective composition does not flow and deforms, The state which maintains the undeformed state which maintained the shape of is meant.

(Embodiment 1)
The method for producing the patch of the present invention will be described in more detail. FIG. 1A is a process diagram for explaining a manufacturing process of a method for manufacturing a patch of an embodiment of the present invention, and FIG. 1B is a manufacturing process of a method of manufacturing a patch of an embodiment of the present invention. It is a schematic process schematic diagram which shows. FIG. 2 is a schematic plan view showing the shape of the cut cooling non-deformation effect composition cut into various shapes according to one embodiment of the present invention.
In FIG. 1, the manufacturing method of the patch of one Example of this invention is (A) The holding member supply process which supplies the holding member 2,
(B) A flow-efficiency composition raw material preparation step for preparing a flow-efficiency composition raw material 1a having a flowable state at the first flow temperature, and (C) the flow-efficiency composition raw material 1a in a non-deformed state. Cooling to two cooling non-deformation temperature to form a non-deformable cooling non-deformation efficacy composition 1b, and then cutting the cooling non-deformation efficacy composition 1b into a predetermined shape to give a cut cooling non-deformation efficacy composition 1c A cooling predetermined shape forming step to be prepared; (D) a cooling non-deformation efficacy composition for laminating the cutting cooling non-deformation efficacy composition 1c on the holding member 2 to prepare a holding member / cutting cooling non-deformation efficacy composition laminate And (E) raising the temperature of the holding member / cutting cooling non-deformation efficacy composition laminate to the third non-flowing flexible temperature, and removing the cutting cooling non-deformation efficacy composition from the cooling non-deformation state. Flexible with no fluidity The effect of preparing the holding member / flexible effect composition laminated composition in which the flexible effect composition 1 is attached to the holding member 2 while being changed to the soft effect composition 1 and attached to the holding member 2. A composition softening adhesion lamination step.
Thereby, the above-mentioned (effect C) operational effect is obtained.

Although not shown in the above manufacturing method, (G) a peeling protection member that is peeled off at the time of use is laminated on the other surface of the flexible efficacy composition, and a holding member, a flexible efficacy composition, and a peeling protection. A method for producing a patch comprising a release member lamination step for preparing a member laminate structure is desirable.
As the peeling member laminating step, (D) the cooling non-deformation efficacy composition for laminating the cutting cooling non-deformation efficacy composition 1c on the holding member 2 to prepare the holding member / cutting cooling non-deformation efficacy composition laminate. After the product laminating step, a peeling protection member is laminated on the cut cooling non-deformation efficacy composition 1c, and then the laminate of the holding member, the cooling non-deformation efficacy composition and the peeling protection member is added to the third layer. A production method including an effect composition softening adhesion lamination step of preparing a holding member / softening effect composition / peeling protection member laminated structure by raising the temperature to a non-flow softening temperature is desirable.
As another example of a peeling member lamination process, after the above-mentioned (E) holding composition and softening effect composition lamination constituent which prepares the effect composition softening adhesion lamination process, It is also possible to carry out a production method including an effect composition softening adhesion lamination step of laminating a release protection member to prepare a holding member / softening effect composition / peeling protection member laminate composition.

The peeling protection member is laminated on the surface of the flexible effect composition having adhesiveness to protect the surface of the flexible effect composition, and is peeled and removed during use.
Although it does not specifically limit as a peeling protection member, While it has the mechanical strength of the grade which can protect the surface of a flexible effect composition at the time of a preservation | save of polyethylene films, polyester films, and other plastic films, it is strong at the time of use A member having adhesiveness that can be easily peeled off from the surface of the flexible effect composition without having adhesiveness can be used.

(C) Cooling predetermined shape forming step of the present invention forms the cooling non-deformable effect composition 1b in the non-deformed state by cooling the flow-effect composition raw material 1a to the second cooling non-deformation temperature at which the fluid effect composition raw material 1a becomes non-deformed, Then, the manufacturing method of a patch provided with the process of cut | disconnecting the said cooling nondeformation effect composition 1b in a predetermined shape and preparing the cutting cooling nondeformation effect composition 1c is desirable. Thereby, the above-mentioned (effect C) operational effect is obtained.
The cutting method for cutting the cooling non-deformation efficacy composition 1b into a predetermined shape is not particularly limited. 1b can be cut into a predetermined shape using a flat plate type press cutting device, a flat plate type press cutting device, a roll type press cutting device, or a roll type press cutting device.
The cutting shape is not particularly limited. For example, as shown in FIG. 2, a rectangle, a circle, an ellipse, a heart shape, other polygons, a flower shape, a symbol shape, an arbitrary animal and plant shape, and any other desired shape By cutting into the shape, the cutting cooling non-deformation effect composition 1b is obtained.
In this cutting step, a plurality of cut cooling non-deformable effect compositions 1b can be formed by cutting into a plurality.

The cooling non-deformable effect composition 1b has a non-deformable state that can be cut at a second cooling non-deformation temperature lower than the first flow temperature and does not deform at the time of cutting. Although it does not specifically limit as a fluid effect | action composition raw material which has the property which becomes the softness | flexibility effect composition 1 which has the softness | flexibility state which does not have fluidity in the 3rd non-flow softening temperature warmed, For example, at least water and the water solution containing the said water A hydrogel composition containing a functional polymer can be used. Thereby, the above-mentioned (effect) effect can be obtained.
A patch produced by using a flow-effect composition raw material having the property of becoming a hydrogel soft-effect composition also has an effect of exerting a cooling effect at least when applied to the skin of a human body.
In addition, a patch in which a plurality of types of hydrogel soft-effect compositions having different effects from each other are arranged in the thickness direction or in a planar region exhibits the above-described effect (Effect e).

In particular, the fluidity-effective composition raw material 1a having the property of becoming a hydrous gel-like flexible-effect composition includes at least water, a crosslinkable water-soluble polymer that is crosslinkable in chemical structure and contains the water, and a crosslinking agent. A crosslinkable water-containing gel composition containing, in the (E) active composition softening adhesion laminating step or after the (E) active composition softening adhesion laminating step, A flow-efficiency composition raw material having the property of cross-linking a polymer in terms of chemical structure to become a hydrous crosslinked gel-like flexible effect composition having no fluidity can be used. Thereby, the above-mentioned (effect) effect can be obtained.
The fluidity-effective composition raw material 1a having the property of becoming a hydrous crosslinked gel-like softness-effective composition having no fluidity is, for example, about 15 ° C to about 90 ° C (desirably about 30 ° C as the first fluidization temperature). To about 80 ° C.) and is in a fluid state that can flow, and is non-flowable in a low temperature region of about 5 ° C. or less (desirably about −30 ° C. to about 3 ° C.) as the second cooling non-deformation temperature. It becomes a non-deformed state that can be cut and does not deform at the time of cutting, and after the step (E) or (E), from the non-deformed state to the third non-flow softening temperature of about 5 ° C. to about 50 In the process of processing at 0 ° C. (preferably about 7 ° C. to about 40 ° C.), it has the property of being chemically structurally cross-linked to become a hydrogel soft and effective composition without fluidity.
The first flow temperature, the second cooling non-deformation temperature, and the third non-flow softening temperature are different depending on the type of the fluid effect composition raw material to be used.

Further, the other fluid efficacy composition raw material 1a having the property of becoming a hydrous gel-like flexible efficacy composition includes at least water and a non-crosslinkable water-soluble polymer that is not structurally crosslinked and contains water. A non-crosslinkable hydrous gel composition, wherein the efficacy composition exhibits a fluid state with fluidity as it becomes higher than about 15 ° C. as the first flow temperature, and is fluid at a temperature lower than about 5 ° C. Non-flowable gel state, and in the (E) effect composition softening adhesion laminating step or after the (E) effect composition softening adhesion laminating step, the cutting cooling non-deformation effect composition A fluid effect composition raw material 1a having the property of treating 1b to room temperature as the third non-flow softening temperature to become a non-flowable, non-flowable gel-state soft active composition can be used. Thereby, the above-mentioned (effect) effect can be obtained.
The fluidity-effective composition raw material 1a having such a non-crosslinkable water-containing gel composition that is not chemically cross-linked is, for example, at about 15 ° C to about 90 ° C as the first flow temperature (desirably about 30 ° C to about 30 ° C). 80 ° C.) Flowable in a fluid state, and becomes non-flowable and cleavable at a low temperature of about −30 ° C. to about 5 ° C. (preferably about −30 ° C. to about 3 ° C.) as the second cooling non-deformation temperature. And is in a non-deformed state to the extent that it does not deform during cutting, and after the step (E) or (E), from the non-deformed state to a third non-flow softening temperature of about 5 ° C. to about 50 ° C. (preferably It has the property of becoming a soft-effect composition 1 having no fluidity around room temperature (about 7 ° C. to about 40 ° C.). The first flow temperature, the second cooling non-deformation temperature, and the third non-flow softening temperature are different depending on the type of the fluid effect composition raw material to be used.
In such a water-containing gel-like soft and effective composition, the second cooling non-deformation temperature that becomes non-flowable and can be cut and does not deform when cut is about 5 ° C. or less. A low temperature region is desirable, more desirably a temperature region of about −30 ° C. to about 3 ° C. In a temperature range exceeding about 5 ° C., as the temperature rises, the fluidity gradually increases, and during the cutting operation, the active ingredient composition tends to re-adhere and cannot be cut with high accuracy. There is a tendency that the raw material of the active composition adheres to the blade mold to be used and is inferior in mass productivity.
When the second cooling non-deformation temperature is about −30 ° C. or lower, it can be easily cut. However, however, the power cost for setting the temperature to about −30 ° C. or lower becomes expensive and the manufacturing cost increases. Tend.
As the first flow temperature, about 15 ° C. to about 90 ° C. is desirable. As the first flow temperature becomes about 15 ° C. or less, the flowability decreases, workability such as mixing of raw materials tends to be inferior, and productivity tends to be inferior. Moreover, when it exceeds about 90 degreeC, there exists a tendency for the heat deterioration of a containing component to arise, or for the inconvenience of containing water to evaporate.
When the third non-flow softening temperature is about 5 ° C. or less, the softening effect composition is somewhat hard and tends to give a sense of incongruity when applied to the human body. Efficacy compositions tend to be too soft and give a sense of discomfort during use.

The water-soluble polymer used as the flow-effect composition raw material 1a having the property of becoming a hydrogel soft effect composition, such as a hydrogel soft effect composition and a crosslinked gel soft effect composition, has water retention. A water-soluble polymer that is high and excellent in shape retention can be used, and the water-soluble polymer may be either a synthetic water-soluble polymer or a natural water-soluble polymer.
In general, the natural water-soluble polymer is not particularly limited, but for example, carrageenan, gelatin, pectin, locust bean gum, xanthan gum, gellan gum, Ernest gum, agarose, dextrin, glucomannan, polyglutamic acid, and salts thereof are used. Can do.

The synthetic water-soluble polymer is not particularly limited. For example, polyacrylic acid, partially neutralized polyacrylic acid, polyacrylic acid salts such as sodium polyacrylate, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, Used for gelatin, carboxymethylcellulose, Ernest gum, methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyglutamic acid, polyglutamic acid salts, partially neutralized polyglutamic acid, alginic acid, alginic acid salts, carboxyvinyl polymer, graft starch, etc. it can.
In order to obtain the desired gel performance, these natural water-soluble polymer and synthetic water-soluble polymer can be mixed and used. In addition, several kinds of these water-soluble polymers can be used in combination. From the viewpoint of water retention and adhesive strength, for example, at least one selected from polyacrylic acid and sodium polyacrylate, and carboxy A mixture with a vinyl polymer or a mixture of a partially neutralized polyacrylic acid and a carboxyvinyl polymer can be used.

  The hydrogel soft and effective composition is composed of a gel composition containing a water-soluble polymer and water, and the gel composition contains additives such as a cross-linking agent, a thickener and a gelling agent. May be used, and may be gelled without using such an additive.

    The hydrogel soft and effective composition is preferably prepared so that the water content is at least 30% by weight or more, up to 95% by weight by appropriately selecting a water-soluble polymer, a crosslinking agent or other additives. It can be contained.

  An aroma oil or a pharmacologically active substance can be contained in the hydrogel soft-acting composition. And when aroma oil and a pharmacologically active substance are contained in the water-containing gel-like soft active composition in this way, these substances are gradually transmitted from the water-containing gel-like soft active composition to the application site P of the body, and the cold and moisturizing effect At the same time, the effects of these substances can be obtained.

  Here, as the aroma oil, essential oil components (essential oils) generally used for aromatherapy can be used as they are. Examples of the essential oil component include those described in Wonder Cellar “84 essential oil components for aromatherapy” and Fragrance Journal. Specifically, Anise, Angelica, Benzo, Immortelle, Chamomile, Garlic, Cardamom, Galvanam, Caraway, Carrot Seed, Guayac Wood, Grapefruit, Cybless, Cedarwood, Star Anise, Sage, Geranium, Celery, Thyme, Tarragon, Terpin , Frankincense, violet, pine, parsley, fennel, black pepper, bodaiju flower, lemon, lemongrass, rosemary, laurel, shimotsukegiku, shimotsueso, cornflower, almond, arnica, fennel, enishida, watercress, gentian, ginger, plum Pear, seaweed, dandelion, chimo, chorei, capsicum, green rose, mint, ash, bullock, melissa, peach, mistletoe, eucalyptus, yokuinin, Vendor, there may be mentioned extracts from forsythia, and the like otherwise thereto.

Further, in the above water-containing gel-like soft and effective composition, for the purpose of increasing the water content, facilitating the movement of the liquid inside the water-retaining gel 20, or promoting the diffusion of the liquid to the application site P It is preferable to disperse the fiber having at least the surface hydrophilicity inside the water-containing gel-like soft active composition and to expose a part of the fiber on the surface.
Examples of the fibers include, but are not limited to, various hydrophilic resin fibers such as pulp, cotton yarn, rayon, and the like, and those obtained by hydrophilically treating the surface of the hydrophobic resin fibers. It is preferable to disperse the fibers so that they are entangled three-dimensionally in the hydrogel soft-acting composition.

  In addition, it contains water-absorbing polymers, compounds that absorb heat when dissolved in water, lower alcohols, menthol, mint oil, and glycerin, polyethylene glycol, sorbitol that evaporates to enhance the cooling and cooling effect. It is also possible to contain a known humectant such as

  In addition, in order to adjust the pH to a range of 4 to 10 in order to obtain a cool feeling of the skin and a refreshing feeling after peeling, the above-mentioned hydrogel soft and effective composition has a pH of 5 to 9. And more preferably in the range of pH 6-8.

  Although it does not specifically limit as a crosslinkable water-soluble polymer, For example, the water-soluble polymer which has a functional group which can be cross-linked in a chemical structural formula is used among said water-soluble polymers. A flow-efficiency composition raw material containing a crosslinkable hydrous gel composition containing polyacrylic acid dissolved in water is used, and is crosslinked by mixing a crosslinker such as a salt compound during the manufacturing process of the patch. A crosslinked hydrous gel composition is obtained. In general, a crosslinked water-containing gel composition that has been cross-linked loses fluidity, maintains water retention and improves shape retention.

Examples of tackifiers include rosin, hydrogenated rosin, rosin ester, hydrogenated rosin ester, polyterpene, terpene phenol, phenol resin, xylene resin, coumarone indene resin, other aliphatic resins (C5 resins), petroleum resins. An alicyclic hydrocarbon resin (hydrogenated aromatic resin) or the like can be used.
Softeners and plasticizers include polybutene, polyisobutylene, dioctyl phthalate, dibutyl phthalate, diethyl phthalate, liquid rosin ester, chlorinated paraffin, process oil, lanolin, IPM, silicone, petrolatum, solid paraffin, liquid paraffin, plastic paste , Beeswax, menthol, limonene, pinene, piperiton, terpinol, carveol, almond oil, olive oil, camellia oil, persic oil, mint oil, sesame oil, soybean oil, mink oil, cottonseed oil, corn oil, safflower oil, grape oil, macadamia nut Oil, egg yolk oil, safflower oil, etc. can be used.

In such a fluid effect composition raw material 1a, as needed, a fragrance, a skin absorption accelerator, an antioxidant, an ultraviolet absorber, an inorganic filler, a polyhydric alcohol, a silicone oil, and other desired ones. It is also possible to contain these additives.
The fragrance is not particularly limited, for example, various aroma oils, anise, angelica, benzoin, immortelle, chamomile, garlic, cardamom, galvanum, caraway, carrot seed, guaiac wood, grapefruit, cybless, cedarwood, star anise, Sage, geranium, celery, thyme, tarragon, turpentine, frankincense, violet, pine, parsley, fennel, black pepper, bodaiju flower, lemon, lemongrass, rosemary, laurel, shimotsukegiku, shimotakeshi, cornflower, almond, arnica, fennel, Enishida, watercress, gentian, camphor, plum, pear, sea bream, dandelion, chimo, chorei, hot pepper, green rose, mint, ash, bukuro Melissa, peach, mistletoe, eucalyptus, Coix seed, lavender, an extract from forsythia, etc. can be used.

Skin absorption enhancers include lanolin, liquid paraffin, beeswax, menthol, limonene, pinene, piperiton, terpinol, carveol, jojoba oil, almond oil, olive oil, camellia oil, persic oil, mint oil, sesame oil, soybean oil, mink oil Cottonseed oil, corn oil, safflower oil, grape oil, macadamia nut oil, egg yolk oil, safflower oil and the like can be used.
As polyhydric alcohols, glycerin, propylene glycol, octanediol, polyethylene glycol, D-sorbite, crotamiton and the like can be used.
As the silicone oil, methylsiloxane, methylphenylpolysiloxane, dodecamethylpolysiloxane and the like can be used.

As another fluid efficacy composition raw material 1a, a fluid efficacy composition raw material 1a that further contains a medicinal component having transdermal absorbability and exhibits a medicinal effect exhibited by the medicinal component when applied to the skin of a human body can be used. . As a result, the above-mentioned effect (Effect) can be obtained.
Examples of such medicinal ingredients include, but are not limited to, for example, indomethacin, loxoprofen, ketoprofen, diclofenac, diclofenac sodium, piroxicam, suprofen, ibuprofen, ketorolac, lidocaine, flurbiprofen, terbinafine, capsaicin, oat extract, mefenamic acid, Dipotassium glycyrrhizinate, menthol, camphor, hyaluronic acid, salicylic acid ester, arbutin, tocopherol acetate, allantoin, vitamins, azulene, acrinol, psyllium extract, other plant extracts, arbutin, tocopherol acetate, vitamin C, water-soluble azulene, Analgesics such as polyphenols, econzymes, and placenta extracts, anti-inflammatory agents, nutrients, tranquilizers, thermal agents, cold Agents, moisturizers, whitening agents, skin blemishes freckles disappear agents, other percutaneous absorption drug, such as can be used.
In addition to these medicinal ingredients, additives such as preservatives, bactericides, fragrances, coloring agents, antioxidants, surfactants, viscosity modifiers and fine powders used in pharmaceuticals and cosmetics can be added. .

The holding member 2 is made of a porous material having a fine uneven surface capable of passing at least one of air, moisture, and moisture. The composition 1c changes from the non-deformed state to the flexible state and a part of the softened flexible effect composition adheres in a state of entering the inside of the unevenness of the fine unevenness surface of the holding member 2, and the flexible effect in the flexible state The composition 1 has such properties as being fixed without being peeled off from the holding member.
Such a holding member 2 is not particularly limited as long as the flexible effect composition 1 penetrates into the holding member 2 and the flexible effect composition 1 is sufficiently held. A fiber assembly such as a nonwoven fabric or a woven fabric using synthetic fibers and natural fibers, and a fiber assembly such as paper can be used. As the holding member 2, in particular, a stretchable structure is desirable, and when the adhesive member laminated with a hydrogel soft effect composition and a non-aqueous elastic composition on the holding member 2 is used on a human body, The patch can be applied to the human body in a stretchable manner, and the patch can be freely expanded and contracted in response to the movement of the human body even after being applied, without separating the boundary between the holding member 2 and the flexible effect composition 1, Further, the patch can be used stably without being peeled off from the human body.

(Embodiment 2)
The schematic process schematic diagram explaining the manufacturing process of the manufacturing method of the other patch of one Example of this invention in FIG. 3 is shown.
In the step (C) cooling predetermined shape forming step of the method for producing a patch of the present invention, the cooling non-deformation efficacy composition 1b is cut into a plurality of predetermined shapes to prepare a plurality of cut cooling non-deformation efficacy compositions 1c. A manufacturing method including the step of performing can also be implemented. That is, as shown in FIG. 3, another manufacturing method of the patch of the present invention includes (A) a holding member supplying step for supplying the holding member 2, and (B) a flowable state at the first flow temperature. A fluidity-efficiency composition raw material preparation step for preparing the fluidity-efficiency composition raw material 1a, (C) the fluidity-efficiency composition raw material 1a is cooled to a second cooling non-deformation temperature at which the fluidity-efficiency composition raw material 1a becomes non-deformed and A cooling predetermined shape forming step of forming a deformable effect composition 1b, and then cutting the cooling non-deformation effect composition 1b into a plurality of predetermined shapes to prepare a plurality of cut cooling non-deformation effect compositions 1c; (D) The plurality of cutting cooling non-deformation efficacy compositions 1c are laminated and adhered to a predetermined surface region of the holding member 2 to prepare a holding member / multiple cutting cooling non-deformation efficacy composition laminated composition. Laminating multiple cooling non-deformable composition And (E) raising the temperature of the holding member and the plurality of cutting cooling non-deformation efficacy composition laminated components to a third non-flowing flexible temperature to obtain the plurality of cutting cooling non-deformation efficacy compositions 1c. A holding member in which a flexible effect composition 1 in a flexible state is attached to the holding member 2 by changing the non-deformed state into a flexible state and attaching the softened flexible effect composition to the holding member. An active composition softening adhesion laminating step for preparing a composition laminating composition.
Thereby, the above-mentioned (effect D) operational effect is obtained.

In the above manufacturing method, as shown in the drawing, (G) a peeling protective member that is peeled off at the time of use is laminated on the other surface of the flexible efficacy composition, and the holding member / flexible efficacy composition / peeling. A method for producing a patch comprising a release member lamination step for preparing a protective member laminate composition is desirable.
In this peeling member laminating step, (D) the plurality of cutting cooling non-deformation effect compositions 1c are laminated and adhered to a predetermined surface region of the holding member 2, and the holding member and a plurality of cutting cooling non-deformation effects are obtained. After the plurality of cooling non-deformation effect composition laminating steps for preparing the composition laminate composition, the peeling protection member 3 is laminated on the plurality of cut cooling non-deformation effect compositions 1c, and then the holding member 2, cutting and cooling non-deformable effect composition 1 c and release protection member 3 are heated to the third non-flowing flexible temperature to form a holding member, a plurality of flexible effect compositions, and a release protection member laminate structure. It is desirable to have a production method comprising an active composition softening adhesion laminating step for preparing the composition. Alternatively, after the above-mentioned (E) holding member-multiple softening composition laminating composition is prepared, the release protection member 3 is laminated on the softening composition 1 after the softening adhesion laminating step. In addition, a manufacturing method including an effect composition softening adhesion laminating step of preparing a holding member, a plurality of flexible effect compositions, and a peel protection member laminated structure can be implemented.
Although not shown, the obtained holding member / flexible effect composition / peeling protection member laminated structure is passed between two rolls to further improve the adhesion between the holding member and the flexible effect composition. In addition, it is possible to provide a step of adjusting the thickness more accurately.

(Embodiment 3)
The manufacturing process figure of the patch of the other Example which comprised the peeling protection member in FIG. 4 is shown. In FIG. 4, the manufacturing method of the patch of another embodiment that constitutes the peeling protection member includes (A) a holding member supplying step for supplying the holding member 2, and (B) a fluid state in which the fluid can flow at the first flow temperature. A fluid efficacy composition raw material preparation step for preparing a fluid efficacy composition raw material 1a having the following: (Ca) The fluidity efficacy composition raw material 1a is cooled to a second cooling non-deformation temperature at which the fluid efficacy composition raw material 1a is brought into an undeformed state, and is in an undeformed state A cooling step of forming the cooling non-deformation efficacy composition 1b of the above, (D) cooling to prepare the holding member / cooling non-deformation efficacy composition laminate by laminating the cooling non-deformation efficacy composition 1b on the holding member 2 Non-deformable composition stacking process,
(G) The holding member / cooling non-deformable effect composition laminate is laminated on the holding member / cooling non-deformation effect composition laminate to prepare the holding member / cooling non-deformation effect composition / peel protection member laminate, and then the holding member / cooling Non-deformation effect composition / peeling protection member laminate cut into a predetermined shape, holding member / cutting cooling non-deformation effect composition / peeling protection member laminate holding member / cooling non-deformation effect composition / peeling protection A member laminate cutting step, and (E) raising the temperature of the holding member / cooling non-deformable effect composition laminate to the third non-flowing flexible temperature to flow the cooling non-deformation effect composition from the cooling non-deformation state. The flexible effect composition 1 is changed to a flexible effect composition 1 having no flexibility, and the flexible effect composition 1 is attached to the holding member 2 and the peeling protection member 3, so that the flexible effect composition 1 is attached to the holding member 2. Soft-effect composition laminate composition / peeling It comprises a potency compositions softening deposition lamination step of preparing the protective member.

As a cutting method for cutting a cooling non-deformation effect composition, a holding member / cooling non-deformation effect composition, or a holding member / cooling non-deformation effect composition / peeling protective member laminate into a plurality of predetermined shapes, in particular Although not limited, for example, a non-deformed cooled strip-like sheet or thin plate-like laminate, a flat-type or roll-type press-cutting device, and a press-cutting device are used to cut and cool a plurality of pieces in a predetermined shape. It can be cut into an effect composition, a holding member / cooling non-deformation effect composition, or a holding member / cooling non-deformation effect composition / peeling protection member laminate.
The cutting shape is not particularly limited, and can be cut into, for example, a rectangle, a polygon, a circle, an ellipse, a heart shape, a flower shape, an arbitrary animal or plant shape, a combination thereof, or any other desired shape. .
Further, a patch comprising a plurality of types of flexible compositions having different effects in a desired thickness, area, shape, weight, lamination position, etc. exhibits the above-mentioned effect (effect a).

  In the above manufacturing method, as shown in FIG. 3, the holding member, the plurality of flexible effect compositions, and the peel protection member laminated structure formed by the above-described step (G) By cutting and separating into a shape, a patch composed of an individual holding member, a flexible effect composition, and a peel protection member laminated structure is obtained.

(Embodiment 4)
FIG. 5 shows a schematic process diagram for explaining the production process of another method for producing a patch of one embodiment of the present invention. In FIG. 5, another method for producing a patch of one embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, and (B) a plurality of types of flow-effect composition raw materials having different composition components. (B1 composition raw material and B2 composition raw material) 11a, 12a plural kinds of fluid effect composition raw material preparation steps, (C) the plural kinds of fluid effect composition raw materials 11a, 12a in an undeformed state Cooling to the second cooling non-deformation temperature to form a plurality of types of cooling non-deformation efficacy compositions (B1 cooling composition and B2 cooling composition) 11b, 12b in an undeformed state, and then each of the plurality of types The cooling non-deformation effect composition is cut into a plurality of predetermined shapes, and a plurality of types of cooling non-deformation effect compositions are cut into a predetermined shape for a plurality of types of cooling non-deformation effect compositions (B1 cutting cooling composition) And B2 cutting A plurality of types / plurality / cutting cooling predetermined shape forming step for preparing 11c and 12c, (D) a plurality of types of cutting cooling non-deformation efficacy compositions 11c on the predetermined surface of the holding member 2; A plurality of types of cutting / cooling non-deformation effect composition stacking steps to prepare a holding member / a plurality of types of cutting / cooling non-deformation effect composition stacking components, and (G) a holding member / a plurality of types Peeling protection member laminating step of laminating the peeling protection member 3 on the cutting cooling non-deformation effect composition laminate structure to adjust the holding member / multiple types of cutting cooling non-deformation effect composition / peeling protection member lamination composition (E) The holding member, the plurality of types of cutting cooling non-deformation efficacy compositions, and the peel protection member laminated composition are heated to a third non-flowing flexible temperature to obtain the plurality of types of cutting cooling non-deformation efficacy compositions. Flexible from undeformed state The flexible effect composition in a flexible state in contact with the holding member is bonded to the holding member, and a plurality of types of flexible effect compositions are bonded to each other to form a flexible effect composition in a flexible state. Comprises a holding member joined to the holding member, a plurality of types of softening effect compositions, and an effect composition softening adhesion laminating step for preparing a peel protection member laminated structure.
Further, in the above manufacturing method, as shown in FIG. 5, the holding member, the plurality of types of flexible effect compositions, and the peel protection member laminated structure formed by the above-described step (E) By cutting and separating into shapes, a patch composed of individual holding members, flexible effect compositions, and peel protection member laminated structures is obtained.

(Embodiment 5)
The schematic process schematic diagram explaining the manufacturing process of the manufacturing method of the other patch of one Example of this invention in FIG. 6 is shown.
In FIG. 6, another patch manufacturing method according to an embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, and (B) a plurality of kinds of flow-effect composition raw materials having different composition components. (B3 composition raw material and B2 composition raw material) A plurality of types of fluid effect composition raw material preparation steps for preparing 13a and 12a, (Ca) The plurality of types of fluid effect composition raw materials 13a and 12a are not deformed. (D) holding | maintenance which cools to the 2nd cooling nondeformation temperature which will be in the state, and forms multiple types of non-deformation cooling nondeformation effect composition (B3 cooling composition and B2 cooling composition) 13b, 12b, A plurality of types of cooling non-deformation efficacy compositions 11b and 12b are sequentially laminated and adhered to a predetermined surface of the member 2 to prepare a holding member and a plurality of types of cooling non-deformation efficacy composition laminated components. Kind of cooling unchanged Effect composition laminating step, (G) Holding member / multiple types of cooling non-deformation effect composition laminated structure, peeling protective member 3 is laminated on holding member / multiple types of cooling non-deformation effect composition / peeling Peeling protection member laminating step for adjusting the protective member laminated structure, (Cb) holding member, plural kinds of cooling non-deformation effect composition / peeling protective member laminated structure are cut into a predetermined shape, and cut into a predetermined shape Holding member having cooling non-deformable effect compositions 13c, 12c, holding member forming plural types of cooling non-deforming effect composition, peeling protection member laminated structure, plural types of cooling non-deforming effect composition, peeling protecting member lamination Cutting the structure, (E) raising the temperature of the holding member, the plurality of types of cooling non-deformation effect composition / peeling protection member laminated composition to a third non-flowing flexible temperature, and the plurality of types of cutting cooling non-deformation effect From the undeformed state of the composition The flexible effect composition in the soft state is bonded to the holding member by changing to the soft state and the soft effect composition in the soft state in contact with the holding member is bonded to the holding member. A holding member in which the product 1 is joined to the holding member 2, a plurality of types of softening effect compositions, and an effect composition softening adhesion laminating step for preparing a peel protection member laminated structure.

Such a patch produced by the steps shown in FIGS. 5 and 6 has the above-mentioned effect (Effect E).
In addition, such a patch having a configuration in which a plurality of types of flexible compositions are laminated and joined in the thickness direction exhibits the above-described effect (effect b).
For example, by the structure which laminated | stacked the 1st flexible effect composition which has a cooling effect or an analgesic effect on the surface of a holding member, and laminated | stacked the 2nd flexible effect composition which has strong adhesive force on the surface of the 1st flexible effect composition In use, a patch having a cooling effect or an analgesic effect and a strong adhesive force can be obtained.

  The shape of the patch having a configuration in which a plurality of types of flexible compositions are laminated and joined in the thickness direction is not particularly limited, and for example, a patch having a shape as shown in FIG. 2 described above can be implemented. .

(Embodiment 6)
The schematic process schematic diagram explaining the manufacturing process of the manufacturing method of the other patch of one Example of this invention in FIG. 7 is shown. In FIG. 7, another method for producing a patch of an embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, and (B) a plurality of types of flow-effect composition raw materials having different composition components from each other. (B1 composition raw material and B2 composition raw material) 11a, a plurality of kinds of fluid effect composition raw material preparation steps for preparing 12a, (C) a second state in which each of the plural kinds of fluid effect composition raw materials is in an undeformed state. A plurality of types of cooling non-deformation effect compositions (B1 cooling composition and B2 cooling composition) 11b and 12b in a non-deformed state are formed by cooling to a cooling non-deformation temperature, and then each of the plurality of types of cooling non-deformation is formed. The effect composition is cut into a plurality of predetermined shapes, and a plurality of types of cooling non-deformation effect compositions cut into a predetermined shape are cut into a predetermined shape (B1 cutting cooling composition and B2 cutting cooling). Composition) 11c, A plurality of types, a plurality of cutting cooling predetermined shape forming steps for preparing 2c, and (D) a plurality of types of cutting cooling non-deformation forming effect compositions at predetermined positions in a planar region of a predetermined surface of the holding member 2 11c and 12c are positioned so as to be adjacent to each other in a plane region, and a plurality of types of cutting cooling non-deformation efficacy composition lamination steps for preparing a holding member and a plurality of types of cutting cooling non-deformation efficacy composition lamination composition, and (E) The holding member and the plurality of types of the cutting cooling non-deformation efficacy composition laminated composition are heated to the third non-flowing flexible temperature, and the plurality of types of cutting cooling non-deformation efficacy compositions 11c and 12c are in the non-deformed state. The flexible effect compositions 11 and 12 are held in the holding member 2 by changing them from the soft state to the soft state and joining the softened multiple kinds of soft effect compositions to each other in the plane region and to the holding member 2. Efficacy composition softening deposition layering step of preparing a flexible efficacy composition stackup of bonded retention member, a plurality of types to the surface comprises a.

  In addition, in the manufacturing method of the patch shown in FIG. 7, the manufacturing method which comprised the peeling protection member 3 can also be implemented. That is, in FIG. 7, after the above-mentioned (D) multiple types of cutting cooling non-deformation efficacy composition lamination step, (G) peeling protection on the holding member / multiple types of cutting cooling non-deformation efficacy composition laminate structure. After the member 3 is laminated, a holding member, a plurality of types of cutting and cooling non-deformation efficacy composition, a peeling protection member stacking step for adjusting the peeling protection member stacking composition, and then (E) the holding member The temperature of the cut cooling non-deformation effect composition / peeling protection member laminated composition is raised to the third non-flowing flexible temperature to change the plurality of types of cutting cooling non-deformation effect compositions 11c and 12c from the non-deformed state to the flexible state. The holding member in which the plurality of types of softening effect compositions 11 and 12 are bonded to the surface of the holding member 2 by bonding the softened types of softening effect compositions to each other in the planar region and to the holding member 2.・ Multiple It comprises a potency compositions softening deposition layering step of preparing a flexible efficacy composition and peeling the protective member stack structure of class.

With the manufacturing method shown in FIG. 7, the above-described (effect) effect can be obtained. In addition, such a patch having a configuration in which a plurality of types of flexible compositions are joined to each other in a planar region exhibits the above-described effect (effect c).
For example, a patch region exhibiting a cooling effect, a patch region exhibiting an analgesic effect, a patch region exhibiting strong adhesiveness, and the like are alternately formed in the lateral direction of the surface region of the holding member. It is possible to obtain a patch that exhibits its efficacy and has excellent adhesive performance.
For example, a first shape flexible effect composition having a strong adhesive force is laminated on the surface of the holding member, and a second shape that exerts a cooling effect or an analgesic effect on the inner region of the surface of the first shape flexible effect composition. By laminating and forming the flexible effect composition, a patch having a strong adhesive force in the surroundings and having a cooling effect or an analgesic effect in the inner region can be obtained.

The shape of the patch having a configuration in which a plurality of types of flexible compositions are arranged and joined in a plane region is not limited to holding, and for example, a patch having a shape as shown in FIG. 8 can be implemented. is there.
FIG. 8 is a schematic plan view showing an embodiment of a layout diagram of a plurality of types of flexible effect compositions produced by the method for producing a patch of the present invention. For example, in (A) to (D) of FIG. 8, the flexible effect composition 11 is a composition having an effect such as cold feeling or warm feeling, and the flexible effect composition 13 is a composition having an effect such as anti-inflammatory analgesia. The flexible effect composition 14 is a composition that provides a refreshing feeling, and the flexible effect composition 12 is a composition that exhibits a stronger adhesive force than the flexible effect compositions 11, 13, and 14. By combining these various soft-effect compositions, it is possible to obtain a patch exhibiting strong adhesive force and excellent effects such as cooling, warmth, analgesia, or warmth. .

(Embodiment 7)
FIG. 9 is a schematic process schematic diagram for explaining the production process of another method for producing a patch of one embodiment of the present invention. In FIG. 9, another patch manufacturing method according to an embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, and (B) a flowable state at the first flow temperature. Fluid effect composition raw material preparation step for preparing fluid effect composition raw material 1a, (AB) laminating the fluid effect composition raw material 1a on the holding member 2 to prepare a holding member / fluid effect composition raw material laminated structure (ABC) The holding member / fluid effect composition raw material laminated structure is cooled to a second cooling non-deformation temperature at which the fluid effect composition raw material 1a is in an undeformed state, The holding member / cooling non-deformation efficacy composition formed with the deformed cooling non-deformation efficacy composition 1b is prepared, and then the holding member / cooling non-deformation efficacy composition is cut into a predetermined shape to hold the holding member / cut cooling Prepare a non-deformable composition A cooling predetermined shape forming step, and (E) raising the temperature of the holding member / cutting cooling non-deformation efficacy composition laminate to the third non-flowing flexible temperature to cool the cutting cooling non-deformation efficacy composition 1c. The flexible effect composition 1 is changed from an undeformed state to a flexible state with no fluidity, and the flexible effect composition 1 is attached to the holding member, so that the flexible effect composition is attached to the holding member. An effect composition softening adhesion laminating step for preparing an effect composition laminate composition.

(Embodiment 8)
FIG. 10 is a schematic process schematic diagram for explaining the production process of another method for producing a patch of one embodiment of the present invention. In FIG. 10, another patch manufacturing method according to an embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, and (B) a flowable state at the first flow temperature. Fluid effect composition raw material preparation step for preparing fluid effect composition raw material 1a, (AB) laminating the fluid effect composition raw material 1a on the holding member 2 to prepare a holding member / fluid effect composition raw material laminated structure (ABC-a) The holding member / fluid effect composition raw material laminated structure is cooled to a second cooling non-deformation temperature at which the fluid effect composition raw material 1a is in an undeformed state. Then, the holding member / cooling effect composition laminate structure in which the non-deformed cooling non-deformation effect composition 1b is formed is adjusted, and then the holding member / cooling effect composition laminate composition is cut into a plurality of predetermined shapes. Multiple holding members A plurality of cutting cooling predetermined shape forming steps for preparing a cutting cooling non-deformation effect composition, (Ea) raising the plurality of holding members / cutting cooling non-deformation effect composition laminate to the third non-flowing flexible temperature The cutting and cooling non-deformable effect composition is changed from a cooling non-deformable state to a soft and flexible state with no fluidity, and the soft and effective composition is attached to the holding member, and the flexible and effective composition The effect composition softening adhesion lamination process which prepares the several holding member and softening effect composition laminated structure in which the thing adhered to the said holding member is provided.

  In addition, in the manufacturing method of the patch shown in FIG. 10, the manufacturing method which comprised the peeling protection member 3 can also be implemented. That is, in FIG. 10, another method of manufacturing a patch according to an embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, and (B) a fluid state in which the fluid can flow at the first fluid temperature. A fluid effect composition raw material preparation step for preparing a fluid effect composition raw material 1a having the following: (AB) The fluid effect composition raw material 1a is laminated on the holding member 2, and the holding member / fluid effect composition raw material laminated composition (ABC-a) Cooling the holding member / fluid effect composition raw material laminated structure to a second cooling non-deformation temperature at which the fluid effect composition raw material 1a is in an undeformed state. Then, the holding member / cooling effect composition laminated composition in which the non-deformed cooling non-deformable effect composition 1b is formed is prepared, and then (ABC-b) the holding member / cooling effect composition raw material laminated composition On top, peel protection The holding member / cooling effect composition / peeling protection member laminated structure is adjusted by laminating the material 3, and then the holding member / cooling effect composition / peeling protection member laminated structure is cut into a plurality of predetermined shapes. A plurality of holding members, a cutting cooling non-deformation effect composition, a plurality of cutting cooling predetermined shape forming step for preparing a peel protection member laminate, (Ea) the plurality of holding members, cutting cooling non-deformation effect composition The laminate / peeling protection member laminate is heated to the third non-flowing flexible temperature, and the cutting cooling non-deformation efficacy composition is changed from the cooling non-deformation status to the flexible efficacy composition 1 having no fluidity. At the same time, the flexible effect composition 1 is attached to the holding member 2 to prepare a plurality of holding member / flexible effect composition / peeling protection member laminated composition in which the flexible effect composition 1 is attached to the holding member 2. Efficacy composition Process includes a,.

(Embodiment 9a)
In this invention, the manufacturing method of the patch which comprised the blister type container can also be implemented. That is, another manufacturing method of the patch of one embodiment of the present invention is the same as that in Embodiments 1 to 7 described above, and (F) the housing recess formed on the upper surface and the ridge formed on the periphery of the recess. A blister type container supplying step for supplying a blister type container, and (AF) a holding member arranging step for adjusting the holding member arranging container by arranging the holding member in the concave portion of the blister type container, (B) The holding | maintenance arrange | positioned at the recessed part of the said blister type container material in the said (D) cooling nondeformation effect composition lamination | stacking process through the flow effect composition raw material preparation process and the said (C) cooling predetermined shape formation process. The cutting cooling non-deformation efficacy composition is laminated on a member to prepare a holding member / cut cooling non-deformation efficacy composition, and then the (E) efficacy composition softening adhesion lamination step is performed. .
In this way, a patch comprising a holding member 2 and a plurality of types of flexible effect compositions 1 housed in a blister type container is obtained.
As a result, the above-described (effect) effect can be obtained. In addition, such a patch comprising a blister-type container has the above-mentioned effect (effect d).

(Embodiment 9b)
About the manufacturing method of the patch which comprised said blister type container, the manufacturing method of the patch of one Example is demonstrated.
FIG. 11 is a schematic process schematic diagram illustrating the manufacturing process of another method of manufacturing a patch according to an embodiment of the present invention. In FIG. 11, another patch manufacturing method according to an embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, (F) an accommodation recess opened on the upper surface, and a periphery of the recess. A blister-type container supply step for supplying a blister-type container 4 having a ridge, and (AF) a holding member arrangement step for adjusting the holding member arrangement container by arranging the holding member in the concave portion of the blister-type container 4; (B) Plural types of fluid effect composition raw materials (B1 composition raw material and B2 composition raw material) 11a, 12a having different composition components from each other, (C) the plural types A plurality of kinds of non-deformable cooling non-deformation effect compositions (B1 cooling composition and B2 cooling composition) by cooling the respective flow-efficiency composition raw materials 11a and 12a to a second cooling non-deformation temperature at which they become non-deformation states. ) 11 12b, and then cutting each of the plurality of types of cooling non-deformable efficacy compositions into a plurality of predetermined shapes, and a plurality of types of cooling non-deformation efficacy compositions cut into a predetermined shape. Cutting cooling non-deformation forming effect composition (B1 cutting cooling composition and B2 cutting cooling composition) 11c, 12c, multiple types, plural, cutting cooling predetermined shape forming step, (D) concave portion of the blister type container material The plurality of types of cutting cooling non-deformation efficacy compositions 11c and 12c are sequentially laminated in a multilayer manner on a predetermined surface of the holding member 2 disposed on the holding member. A plurality of types of cutting cooling non-deformation effect composition laminating step for preparing a layered composition, (G) a blister and a holding member of the blister container material, and a plurality of types of cutting cooling non-deformation effect composition laminating composition Peeling protection member laminating step of laminating the protective member 3 to adjust the holding member, a plurality of types of cutting cooling non-deformation effect composition / peeling protection member laminated composition, (E) the holding member, a plurality of types of cutting cooling non-cooling Raising the deformable effect composition / peeling protection member laminated composition to a third non-flowing flexible temperature, changing the plurality of types of cutting cooling non-deformable effect compositions from a non-deformed state to a flexible state, and the holding member The flexible effect composition in a flexible state in contact with the adhesive member is joined to the holding member, and plural kinds of flexible effect compositions are joined to each other, and the peeling protection member 3 covers the plural kinds of flexible effect compositions 11 and 12. A holding member, a plurality of types of softening effect compositions, and an exfoliation protection member laminating composition for preparing a laminate composition of peel protection members, which are configured in close contact with the blisters of the blister-type container 4 in a state of being covered.
As a result, the above-described (effect) effect can be obtained. In addition, such a patch comprising a blister-type container has the above-mentioned effect (effect d).

(Embodiment 9c)
About the manufacturing method of the patch which comprised said blister type container, the manufacturing method of the patch of one Example is demonstrated.
FIG. 12 is a schematic process schematic diagram for explaining the production process of another method for producing a patch of one embodiment of the present invention. In FIG. 12, another manufacturing method of the patch of one embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, and (F) an accommodation recess opened on the upper surface and the periphery of the recess. A blister-type container supply step (AF) for supplying a blister-type container 4 having a ridge, and a holding member arrangement step for adjusting the holding member arrangement container by arranging the holding member in the concave portion of the blister-type container 4; B) Plural kinds of fluid effect composition raw materials (B1 composition raw material and B2 composition raw material) 11a, 12a having different composition components from each other, (C) the plural kinds of fluid effect composition raw material preparation steps A plurality of kinds of cooling non-deformation effect compositions (B1 cooling composition and B2 cooling composition) 11b, 12b in a non-deformation state by cooling the respective flow effect composition raw materials to a second cooling non-deformation temperature that becomes an undeformation state. Forming Thereafter, the plurality of types of cooling non-deformation efficacy compositions are cut into a plurality of predetermined shapes, and the plurality of types of cooling non-deformation efficacy compositions are cut into a predetermined shape. Plural types / plurality / cut cooling predetermined shape forming step for preparing compositions (B1 cutting cooling composition and B2 cutting cooling composition) 11c, 12c, (D) holding member disposed in the concave portion of the blister type container 4 The plurality of types of cutting cooling non-deformation forming effect compositions 11c and 12c are positioned adjacent to each other in a plane area on a predetermined surface area of the holding surface and a plurality of types of cutting. A plurality of types of cutting cooling non-deformation efficacy composition laminating steps for preparing a cooling non-deformation efficacy composition laminate composition, and (E) the holding member / multiple types of cutting cooling non-deformation efficacy composition laminate composition as a third The temperature is raised to the fluid softening temperature, and the plurality of types of cut cooling non-deformation active compositions 11c and 12c are changed from the non-deformed state to the soft state, and the softened multiple types of soft effect compositions are joined to each other in a planar region. The flexible composition is prepared by bonding the holding member 2 to the holding member 2 to prepare the holding member / multiple types of flexible effect composition laminated composition in which the plural kinds of flexible effect compositions 11 and 12 are bonded to the surface of the holding member 2. And a deposition process.

In addition, in the manufacturing method of the patch shown in FIG. 12, the manufacturing method which comprised the peeling protection member 3 can also be implemented.
That is, in FIG. 12, after (D) the plural types of cutting cooling non-deformation effect composition laminating step described above, (G) the holding member arranged in the blister-type container 4 and the recess, and plural types of cutting cooling. Through the peeling protection member laminating step of laminating the peeling protection member 3 on the non-deformation effect composition laminate structure and adjusting the holding member / multiple types of cutting cooling non-deformation effect composition / release protection member laminate composition. Then, (E) the holding member, the plurality of types of cutting cooling non-deformation efficacy compositions, and the peel protection member laminated composition are heated to a third non-flowing flexible temperature to produce a plurality of types of cutting cooling non-deformation efficacy compositions. 11c, 12c is changed from a non-deformed state to a flexible state, and a plurality of kinds of softened flexible effect compositions are joined to each other in a planar region and joined to the holding member 2 to obtain a plurality of kinds of flexible effect compositions 11, 12 A holding member that is bonded to the surface of the holding member 2 and is in close contact with the ridge of the blister-type container 4 in a state in which the peeling protection member 3 covers the multiple types of flexible effect compositions 11 and 12. An effect composition softening adhesion lamination process which prepares a flexible effect composition and a peeling protection member lamination constituent is provided.
As a result, the above-described (effect) effect can be obtained. In addition, such a patch comprising a blister-type container has the above-mentioned effect (effect d).

(Embodiment 9d)
Similar to the embodiment 9d described above, a method for producing a patch in which four types of flexible effect compositions are arranged in a planar region will be described.
The manufacturing method of the other patch of the embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, (F) an accommodation recess opened on the upper surface, and a ridge formed around the recess. A blister type container supplying step for supplying a blister type container 4 having (A) a holding member arrangement step for adjusting the holding member arrangement container by arranging the holding member in the recess of the blister type container 4; Plural kinds of fluidity composition raw material preparations for preparing plural kinds of fluidity effect composition raw materials (B1 composition raw material 11a, B2 composition raw material 12a, B3 composition raw material 13a, B4 composition raw material 14a) having different composition components Step (C) Cooling the raw materials of each of the plurality of types to the second cooling non-deformation temperature at which the raw materials are in a non-deformed state and cooling them to a plurality of types of non-deformable cooling non-deformation effect compositions (B1 cooling composition) 11b, B A cooling composition 12b, a B3 cooling composition 13b, and a B4 cooling composition 14b), and then cutting each of the plurality of types of cooling non-deformation effect compositions into a plurality of predetermined shapes to form a plurality of types of cooling. A plurality of cutting cooling non-deformation effect compositions (B1 cutting cooling composition 11c, B2 cutting cooling composition 12c, B3 cutting cooling composition 13c, B4 cutting cooling composition 14c cut into a predetermined shape for the non-deforming effect composition A plurality of types of cutting and cooling predetermined shape forming step, (D) a plurality of types of the plurality of types at predetermined positions in a planar region of a predetermined surface of the holding member 2 disposed in the concave portion of the blister container 4 As shown in FIG. 8 (C), the cutting cooling non-deformation forming effect compositions 11c, 12c, 13c, and 14c are positioned so as to be adjacent to each other in the plane region, and the holding member / multiple types of cutting A plurality of types of cutting cooling non-deformation efficacy composition laminating step for preparing a non-deformable efficacy composition laminate composition, (G) a holding member arranged in the recess and a plurality of types of cutting cooling Through a peeling protection member laminating step of laminating the peeling protection member 3 on the deformable effect composition laminated structure and adjusting a holding member, a plurality of types of cutting cooling non-deformation efficacy composition / peeling protection member laminated composition, Thereafter, (E) the holding member, the plurality of types of cutting cooling non-deformation efficacy composition / peeling protection member laminated composition is heated to the third non-flowing flexible temperature, and the plurality of types of cutting cooling non-deformation efficacy composition 11c. , 12c is changed from the non-deformed state to the flexible state, and the plural kinds of softened flexible effect compositions are joined to each other in the planar region and joined to the holding member 2 to obtain the plural kinds of flexible effect compositions 11, 12 Hold A holding member that is bonded to the surface of the blister type container 4 in a state of being bonded to the surface of the member 2 and covering the plurality of types of flexible effect compositions 11 and 12 with the peeling protection member 3. An effect composition softening adhesion lamination step of preparing an effect composition / peeling protection member laminate structure is provided.

(Embodiment 9e)
FIG. 13 is a schematic process schematic diagram for explaining the production process of another method for producing a patch of one embodiment of the present invention. In FIG. 13, in the above-described embodiment 9b or 9c, the flexible effect composition 1 is disposed on the bottom surface side of the concave portion of the blister-type container 4, and the holding member 2 is disposed on the flexible effect composition 1. This is a method for producing a patch in which the peel protection member is configured in a state where the flexible effect composition / holding member laminate disposed in the ridge of the mold container and the recess of the blister mold container 4 is covered. That is, in FIG. 13, another manufacturing method of the patch of one embodiment of the present invention includes (A) a holding member supplying step for supplying the holding member 2, and (F) an accommodation recess opened on the upper surface and the periphery of the recess. A blister-type container supply step for supplying a blister-type container 4 having a ridge formed thereon, (B) a plurality of types of flow-effect composition raw materials (B1 composition raw material and B2 composition raw material) 11a having different composition components from each other, A plurality of types of flow-efficiency composition raw materials for preparing 12a, (C) a plurality of the plurality of types of flow-efficiency composition raw materials that are cooled to a second cooling non-deformation temperature at which they become non-deformed, The types of cooling non-deformation efficacy compositions (B1 cooling composition and B2 cooling composition) 11b and 12b are formed, and then the plurality of types of cooling non-deformation efficacy compositions are cut into a plurality of predetermined shapes. Multiple types Plural types / plurality / cutting cooling for preparing a plurality of cutting cooling non-deformation efficacy compositions (B1 cutting cooling composition and B2 cutting cooling composition) 11c, 12c cut into a predetermined shape for the rejection non-deformation efficacy composition Predetermined shape forming step, (D) (i) the plurality of types of cut cooling non-deformation forming effect compositions 11c and 12c are planarly disposed at predetermined positions in a planar region of a predetermined surface of the concave portion of the blister container 4; A plurality of types of cutting and cooling non-deformation efficacy composition layered steps for preparing a holding member and a plurality of types of cutting and cooling non-deformation efficacy composition layered components, or (ii) the blister type The plurality of types of cutting cooling non-deformation forming effect compositions 11c and 12c are sequentially laminated in a concave portion of the container 4 to form a holding member and a plurality of types of cutting cooling non-deforming effect composition laminating composition. A plurality of types of cutting cooling non-deformation effect composition laminating steps to be prepared, (AF) placing the holding member on the cutting cooling non-deformation forming effect compositions 11c, 12c arranged in the recess of the blister type container 4 A holding member arrangement step of adjusting the holding member arrangement container, and (E) raising the holding member / a plurality of types of the cutting cooling non-deformation effect composition laminated composition to a third non-flowing flexible temperature, By changing the cutting cooling non-deformable effect composition 11c, 12c from the non-deformed state to the flexible state, a plurality of types of softened flexible effect compositions are joined to each other and joined to the holding member 2 to obtain a plurality of types of flexible A holding member in which the efficacy compositions 11 and 12 are bonded to the surface of the holding member 2, and an efficacy composition softening and adhesion laminating step for preparing a plurality of types of flexible efficacy composition laminate components.

In addition, the manufacturing method which comprised the peeling protection member 3 in the manufacturing method of the patch shown in FIG.
That is, in FIG. 13, the holding member is arranged on the cutting cooling non-deformation forming effect composition 11c, 12c arranged in the concave portion of the (AF) blister type container 4 to adjust the holding member arrangement container. After the holding member arranging step, the peeling protection member 3 is laminated on (G) the blister of the blister-type container 4 and the holding member arranged in the concave portion / multiple types of cut cooling non-deformation effect composition laminated structure. Through a holding member, a plurality of types of cutting cooling non-deformation effect composition / peeling protection member laminating step for adjusting a peeling protection member laminated structure, and then (E) the holding member / multiple types of cutting cooling non-deformation effect The composition / peeling protection member laminated structure was heated to the third non-flowing flexible temperature, and the plurality of types of cutting cooling non-deformable effect compositions 11c and 12c were changed from the non-deformed state to the flexible state to be softened. Multiple types The soft-effect compositions are joined to each other in a planar region and joined to the holding member 2, and a plurality of types of flexible-effect compositions 11 and 12 are joined to the surface of the holding member 2, and the peeling protection member 3 is attached to the holding member 2. An effect composition softening adhesion lamination step of preparing a holding member, a plurality of types of softening effect compositions, and a peel protection member laminated structure formed in close contact with the ridge of the blister type container 4 in a state of covering the container.
As a result, the above-described (effect) effect can be obtained. In addition, such a patch comprising a blister-type container has the above-mentioned effect (effect d).

(Embodiment 9f)
FIG. 14 shows a schematic process diagram for explaining the production process of another method for producing a patch of one embodiment of the present invention, and (A) shows a configuration in which a plurality of types of flexible effect compositions are laminated in multiple layers. (B) shows a configuration in which a plurality of types of flexible effect compositions are arranged in a planar region. FIG. 14 shows the above-described Embodiments 9b and 9c, in which the peeling protection member is configured with covering the flexible effect composition / holding member laminate disposed in the blister container and the recess of the blister container 4 and reducing the pressure. It is the manufacturing method of the patch which joins the said peeling protection member and the blister of the said blister type container in a state, and prepares a pressure-reduced sealed package. That is, the method for manufacturing a patch constituting another blister type container of the present invention further includes (G-a) a peeling protection member supplying step for supplying the peeling protection member, and (Gb) the holding member.・ Installing the peeling protection member in a state where the other surface of the cutting cooling non-deformation effect composition and the blister of the blister container are covered, and the holding member / cutting cooling non-deformation effect composition laminate from atmospheric pressure The peeling protection member and the blister-type container are joined in a state where the pressure is reduced to a reduced pressure state, thereby providing a sealing step of preparing a reduced pressure sealed package.
In addition, although not illustrated in FIG. 14, in the above-described embodiment 9d, (Gb) in a state where the other surface of the holding member / cutting cooling non-deformable effect composition and the blister of the blister type container are covered. While installing the peeling protection member, in a state where the holding member and the cutting cooling non-deformable effect composition laminate is depressurized to be in a reduced pressure state from atmospheric pressure, the peeling protection member and the blister container Thus, it is possible to implement a process including a sealing process for preparing a vacuum sealed package. Thereby, the above-mentioned (effect H) operational effect is obtained.

A blister-type container is a container having a shape in which a ridge is formed on the recess and the periphery of the recess, and the flexible effect composition is accommodated in the recess.
A container shape in which irregularities, ridge ribs, wrinkles, and the like are formed in a two-dimensional direction such as a mesh shape in a region other than the concave portion in which the flexible effect composition of the blister type container is stored is desirable. Thereby, even when the flexible effect composition is formed in a large flaky shape, a flaky patch in which distortion, deflection and the like are suppressed can be obtained.

Such blister-type container materials include thermoplastics (for example, polyethylene, polypropylene, polyethylene terephthalate, polystyrene, polyamide, acrylic resin, etc.) capable of injection molding, vacuum forming, pressure forming, aluminum foil, aluminum A vapor-deposited plastic container or the like can be used, but is not limited thereto. In consideration of the properties of the flexible effect composition to be accommodated, it is preferable to use a material having characteristics such as translucency or light shielding properties. The blister container may be composed of a single resin, or may be a laminate of a plurality of plastic layers, or a laminate of a plastic layer and a metal layer or other layers. The thickness of the blister container is preferably set so as to have mechanical strength that can withstand the force applied during carrying, distribution, storage, etc. For example, in the case of injection molding, 30 to 1000 μm is desirable.
As the peel protection part, a plastic film such as polyethylene, polypropylene, polyethylene terephthalate, polystyrene, polyamide, acrylic resin, or a laminate film obtained by laminating these plastic films is used, and in particular, polyethylene terephthalate, polystyrene, polyamide film and the like. It is desirable to use a laminate film laminated with polyethylene or polypropylene as the heat welding layer.

  In the step of joining the blister-type container material and the peel protection part and vacuum-sealing the cut cooling non-deformation active composition so as to be in a reduced pressure state from the atmospheric pressure to obtain a vacuum sealed package, By thermally welding the ridges formed around and the peeling protection member, they are easily sealed and joined in a reduced pressure state. As a method for sealing the blister container and the peeling protection member in a reduced pressure state, for example, the holding member / flexible effect composition laminated structure in which the blister container is disposed and the peeling protection member can be greatly reduced in pressure. In a vacuum suction capable container, the blister type container and the peeling protection member are heat-welded in a state where the vacuum suction capable container is decompressed to a predetermined degree of vacuum. By returning to atmospheric pressure, a patch sealed under reduced pressure is obtained.

  As such a peeling protection member used together with the blister type container, in addition to the above-mentioned peeling protection member, for example, the holding member / flexible effect composition laminated structure is shielded from the outside atmosphere such as air and humidity. It is desirable to use a package having an air humidity barrier property that can prevent the performance change such as deterioration of the flexible effect composition, for example, an exterior film such as a polyester film or a polyamide film, and an aluminum foil or an aluminum vapor deposited film. A peel protection member comprising a laminate film obtained by laminating a metal layer having air barrier properties and a heat-weldable weld layer such as a polyethylene film or a polypropylene film can also be used.

  There is no particular limitation on the depressurized state in which the depressurized state is lower than the atmospheric pressure, but for example, a range of 10 mmHg to 700 mmHg is desirable. In the case of a vacuum higher than 10 mmHg, a long-time vacuum suction operation is required to obtain a reduced pressure state, so that productivity tends to be inferior, and contained components may vaporize. Therefore, the reduced pressure state is particularly preferably in the range of about 100 mmHg to about 600 mmHg.

  Hereinafter, typical examples of the method for producing a patch and the patch of the present invention will be described.

(Typical Example 1: Preparation of various flow-effect composition raw materials)
(Typical Example 1-1: Fluidity Effect Composition Raw Material Preparation Step for Preparing B1 Fluidity Effect Composition Raw Material 11a having a Flowable Flowing State):
Prepare 4 g of sodium polyacrylate, 1 g of gelatin, 2 g of polyvinyl alcohol, 18 g of glycerin, 1 g of sodium carboxymethylcellulose, 2 g of carrageenan, 1 g of ethyl alcohol, 0.1 g of paraben, 70.9 g of water, and 100 g in total. Next, gelatin and carrageenan are heated to about 80 ° C. in 20 g of water to obtain a dissolved product a. Moreover, polyvinyl alcohol is heated to about 80 ° C. in 20 g of water to obtain a dissolved product b. These warming melted material a and warming melted material b are mixed and mixed well by stirring. Separately, sodium polyacrylate, sodium carboxymethylcellulose, and glycerin are mixed and heated to about 80 ° C. to obtain a dissolved product c. Add these lysate a, lysate b, lysate c, paraben and the remaining water, warm to about 80 ° C., mix and stir, then lower the solution temperature to about 70 ° C. to about 75 ° C. Wait for bubbles in this solution to be eliminated. In this way, a B1 fluidity effect composition raw material 11a of about 70 ° C. to about 75 ° C. in which the respective components are uniformly mixed is prepared.
The B1 fluidity-effective composition raw material 11a prepared in this way has a fluid state in which it can flow in a temperature range of about 40 ° C. or more as the first fluid temperature, and about 3 ° C. as the second cooling non-deformation temperature. It becomes a non-deformable state that can be cut in the following temperature range, and becomes a hydrogel soft-acting composition having no fluidity in the temperature range of about 7 ° C. to about 40 ° C. as the third non-flow temperature.
The patch comprising the hydrated gel-like soft-effect composition has an effect of exerting a cooling effect or a cooling sensation effect when used by being applied to the human body.

(Typical Example 1-2)
Flow-efficiency composition raw material preparation step for preparing the B2 flow-efficiency composition raw material 12a having a flowable state):
The total amount of the fluid effect composition raw material 12a was 100% by mass to prepare a gel composition having the following formulation. That is, first, a predetermined amount of water is taken into another container, and 0.02% by mass of a crosslinking agent (KCl) is added thereto. Separately, about half the amount of butylene glycol gel components such as copper carrageenan 0.6% by mass, locust bean gum 0.2% by mass, glucomannan 0.4% by mass, polyacrylic acid partial neutralized product 0.05% by mass, etc. After adding it little by little to 5% by mass with stirring, 3% by mass of silica powder (Silo Pure 25) is added little by little and stirred well to obtain a gel component / silica powder wetting liquid. The gel component may be previously wetted and dispersed in a small amount of ethanol. On the other hand, the remaining 5 parts by weight of butylene glycol was added to a preservative (paraben 0.2% by weight) and polyethylene glycol 1% by weight, and active ingredients (raspberry ketone 0.5% by weight, caffeine 0.1% by weight, tea extract 0. 1% by mass, seaweed extract 0.1% by mass, glucose sugar component 2% by mass) and completely dissolved with stirring under heating to obtain a butylene glycol solution. When the rough heat of the butylene glycol solution is removed, the solution is added little by little to the gel component / silica powder wetting liquid with good stirring. This is then added to the remaining water with 5% by weight of sorbitol with good stirring to swell the gel component. When the obtained gel component swelling liquid is heated to about 80 to 85 ° C. and the swollen gel component is uniformly dissolved, a separately prepared crosslinking agent aqueous solution is added dropwise with stirring to the mixture at 80 to 85 ° C. Maintain for about 30 minutes. Then, it is immersed in a water bath adjusted to 70 to 75 ° C. to lower the solution temperature, and waits for bubbles in the solution to be eliminated. In this way, the B2 fluid effect composition raw material 12a of about 70 ° C. to about 75 ° C. (first fluid temperature) in which the respective components are uniformly mixed is prepared.
The B2 fluidity-efficiency composition raw material 12a thus prepared has a fluid state that can flow in a temperature range of about 40 ° C. or more as the first fluid temperature, and about 3 ° C. as the second cooling non-deformation temperature. It becomes a non-deformable state that can be cut in the following temperature range, and becomes a hydrogel soft-acting composition having no fluidity in the temperature range of about 7 ° C. to about 40 ° C. as the third non-flow temperature.
When the patch comprising this hydrogel soft-effect composition is applied to the human body, it exhibits a cooling effect or a cold-sensing effect, and a hydrogel form using the aforementioned B1 fluidity-effect composition raw material 11a. It has the effect of exerting a stronger adhesive force than the flexible effect composition.

(Typical Example 1-3)
Fluidity effect composition raw material preparation step of preparing the B3 fluidity effect composition raw material 13a having a flowable state:
In the process of the above-described exemplary embodiment 1, the process further includes adding and mixing and dissolving about 0.1 g of indomethacin as a medicinal ingredient having an analgesic / anti-inflammatory effect. In this way, a B3 fluidity effect composition raw material 13a of about 70 ° C. to about 75 ° C. in which the respective components are uniformly mixed is prepared.
The B3 fluidity-efficiency composition raw material 13a thus prepared has a fluid state that can flow in a temperature range of about 40 ° C. or more as the first fluid temperature, and about 3 ° C. as the second cooling non-deformation temperature. It becomes a non-deformable state that can be cut in the following temperature range, and becomes a hydrogel soft-acting composition having no fluidity in the temperature range of about 7 ° C. to about 40 ° C. as the third non-flow temperature.
The patch comprising this hydrogel soft-effect composition has an effect of exerting a cooling effect or a cold-sensing effect and an analgesic / anti-inflammatory effect when used on a human body.

(Typical Examples 1-4)
Flow-effective composition raw material preparation step for preparing a flow-effective composition raw material 14a having a flowable flow state: In the above-described typical example 1, in addition to about 1-menthol as a medicinal active ingredient having a cooling sensation. 1. Add 1 g, mix and dissolve. In this way, a B4 fluidity effect composition raw material 14a at about 70 ° C. to about 75 ° C. in which the respective components are uniformly mixed is prepared.
The B3 fluidity-efficiency composition raw material 13a thus prepared has a fluid state that can flow in a temperature range of about 40 ° C. or more as the first fluid temperature, and about 3 ° C. as the second cooling non-deformation temperature. It becomes a non-deformable state that can be cut in the following temperature range, and becomes a hydrogel soft-acting composition having no fluidity in the temperature range of about 7 ° C. to about 40 ° C. as the third non-flow temperature.
When the patch comprising the hydrogel soft-effect composition is applied to a human body, it has a cooling effect or a cooling sensation effect and an effect of cooling effect.

(Typical Example 2)
Manufacture of a patch comprising a water-containing gel-like soft-acting composition:
A typical example related to Embodiment 1 shown in FIG. 1 will be described.
(Step A) Holding member supply step: Holding made of a non-woven fabric having a thickness of about 1 mm, a length of about 300 mm and a width of about 300 mm containing polyethylene terephthalate fibers and other binders, and a flexible air permeability. Prepare the parts.
(Step B) B1 flow effect composition of about 40 ° C. to about 70 ° C. (first flow temperature) in which each component is uniformly mixed or dissolved in the same manner as in the above-mentioned typical example 1-1. A material 11a is prepared. The B1 fluidity effect composition raw material 11a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm to a thickness of about 1.5 mm.
(Step C) Cooling predetermined shape forming step: B1 fluidity-efficiency composition raw material 11a is cooled to a second cooling undeformation temperature of about −10 to about 3 ° C. at which the non-deformation state is achieved, and a cooling non-deformation effect composition in an undeformed state Then, the cooling non-deformation effect composition 11c is prepared by cutting the cooling non-deformation effect composition into an elliptical shape shown in FIG. 2C.
(D) The oval cut cooling non-deformation efficacy composition 11c cut on the holding member 2 is laminated to prepare a holding member / cut cooling non-deformation efficacy composition laminate.
(E) The holding member / cutting cooling nondeformation effect composition laminate is heated to a third non-flow softening temperature of about 10 ° C. to about 25 ° C. Holding member / flexible effect composition in which flexible effect composition 11 is attached to holding member 2 by changing to flexible effect composition 11 in a flexible state having no fluidity and attaching the flexible effect composition 11 to holding member 2 A laminated composition is prepared.
In this way, a planar elliptical holding member / flexible effect composition laminate structure having a lateral width of 14 cm, a vertical width of 10 cm, and a thickness of about 1.5 mm is obtained.
By such a manufacturing method, the effects (Effect A), (Effect B), and (Effect C) were obtained. Moreover, the patch obtained in this way has a cooling effect when applied to the skin of the human body.

The aforementioned (C step) cooling predetermined shape forming step will be described in detail. FIG. 15 is a schematic view showing an example of the step of cutting the cooling non-deformable efficacy composition of the method for producing a patch of the present invention. In FIG. 15, a pressing blade die 7 having a double-edged shape having a tip edge angle of 30 degrees and a height of about 5 mm is mounted on the upper plate 9 of the flat plate cutting apparatus and cooled in a cooling state of about −10 ° C. to about 3 ° C. In a state where the non-deformable effect composition 11b is arranged in the lower plate of the flat plate cutting device, the upper board 9 is operated to cut the cutting cooling non-deformation effect composition 11c to have an elliptical cooling non-deformation effect of a predetermined shape. Composition 11c is obtained.
At the time of cutting, the cooling non-deformation efficacy composition 11b was cut without flowing and without being deformed, and the cooling non-deformation efficacy composition 11c having a desired elliptical shape accurately separated was obtained. That is, the cutting cooling non-deformation effect composition 11c having a desired shape with high accuracy in a desired thickness, area, shape, weight and the like was obtained. Moreover, deposits, such as a residue of a cooling nondeformation effect composition, were not recognized by the blade edge | tip of the press cutting blade type | mold 7 after cutting | disconnection operation | movement.

(Comparative Example 2)
On the other hand, the B1 fluid effect composition raw material 11a of about 70 ° C. to about 75 ° C. (first fluid temperature) obtained in the step (B) is about 20 ° C. to about 25 ° C. near room temperature. As a result of performing the same cutting operation as described above using the cutting apparatus shown in FIG. 15 on the fluidity composition raw material at about 20 ° C. to about 25 ° C., the fluidity composition composition raw material immediately flows and deforms Again, the fluidity composition raw materials that were cut were mixed with each other and could not be cut accurately.
In addition, after the cutting operation, a large amount of residue of the fluid effect composition raw material adhered to the cutting edge of the press cutting blade die 7.

(Typical Example 3)
Manufacture of a water-containing gel-like soft-effect composition patch comprising a step of preparing a plurality of cutting-cooling non-deformation-effect compositions 1c A typical example relating to Embodiment 2 shown in FIG. 3 will be described.
That is, as shown in FIG. 3, the manufacturing method of the patch of one embodiment of the present invention is the same as the above-mentioned typical embodiment (step A) holding member supplying step: thickness containing polyethylene terephthalate fiber and the like. A holding member supplying step of supplying a non-woven holding member having a flexibility of about 1 mm, a width of about 500 mm, and a length of about 300 mm, and air humidity permeability, and (B) the first flow temperature (about 40 ° C. to about 40 ° C. The fluidity composition raw material preparation step for preparing the B1 fluidity effect composition raw material 11a having a fluid state that can flow at 70 ° C. is performed. The B1 fluidity effect composition raw material 11a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm to a thickness of about 1.5 mm. (C) The fluidity-efficiency composition raw material 11a is cooled to a second cooling non-deformation temperature (about −10 to about 3 ° C.) at which the flow-efficiency composition raw material 11a is brought into a non-deformed state to form a non-deformable cooling non-deformation effect composition 11b Then, the cooling non-deformation effect composition 11b is cut into a plurality of rectangles having a width of 14 cm and a length of 10 cm in the same manner as in the second exemplary embodiment. A cooling predetermined shape forming step to be prepared; (D) a plurality of cutting cooling non-deformation effect compositions 11c are laminated and adhered to a predetermined surface region of the holding member 2 to hold the holding member and a plurality of cutting cooling non-deformation effects; A plurality of cooling non-deformation effect composition laminating steps for preparing a composition laminate composition, and then a peeling protection member laminating step for laminating the peeling protection member 3 on the plurality of cut cooling non-deformation effect compositions 11c, And (E) the holding part -A plurality of cutting cooling non-deformation efficacy compositions-The peel protection member laminate composition is heated to a third non-flow softening temperature (about 10 to about 25 ° C), and the plurality of cutting cooling non-deformation efficacy compositions 11c is changed from the non-deformed state to the flexible state and the softened flexible effect composition is attached to the holding member, and the flexible member 11 having the soft state is attached to the holding member 2 An effect composition softening adhesion lamination process which prepares a flexible effect composition and a peeling protection member lamination constituent is provided. Thereafter, the holding member, the plurality of flexible effect compositions / peeling protection member laminated structure, the predetermined positions of the holding member containing the flexible effect composition and the peeling protection member are cut, and the individual holding members / flexible effect compositions are cut. An article / peeling protection member laminated structure is prepared.
As the peeling protection member 3, a polyester (polyethylene terephthalate) film having a thickness of about 0.01 mm was used.
In this way, a rectangular holding member / flexible effect composition / peeling protective member laminate structure having a width of 14 cm, a length of 10 cm, and a thickness of about 2.51 mm is obtained.
In addition, the obtained individual holding member / flexible effect composition / peeling protection member laminated structure was passed between two rolls with a spacing of about 2.5 mm, and the width was 14 cm, the length was 10 cm, and the thickness was about 2.50 m. It is also possible to prepare a rectangular holding member / flexible effect composition / peeling protection member laminated structure. Thereby, the above-mentioned (effect D) operational effect is obtained.

  In such a manufacturing process, at the time of cutting, the cooling non-deformation efficacy composition 11b does not flow, deforms, and is cut and accurately separated into the desired shape of the cooling non-deformation efficacy composition 11c. Obtained. That is, the cutting cooling non-deformation effect composition 11c having a desired shape with high accuracy in a desired thickness, area, shape, weight and the like was obtained. Moreover, deposits, such as a residue of a cooling nondeformation effect composition, were not recognized by the blade edge | tip of the press cutting blade type | mold 7 after cutting | disconnection operation | movement.

(Comparative Example 3)
On the other hand, the B1 fluid effect composition raw material 11a of about 40 ° C. to about 70 ° C. (first fluid temperature) obtained in the above-mentioned step (B) is left until it reaches about 20 ° C. to 25 ° C. near room temperature. As a result of performing the same cutting operation as described above using the cutting device shown in FIG. 15 on the fluidity composition raw material at about 20 ° C. to 25 ° C., the fluidity composition composition raw material immediately flows and deforms after the cutting operation. Again, the cut fluidity composition raw materials were mixed with each other and could not be cut accurately. In addition, after the cutting operation, a large amount of residue of the fluid effect composition raw material adhered to the cutting edge of the press cutting blade die 7.

(Typical Example 4)
Production of a water-containing gel-like soft-acting composition patch comprising a step of preparing a plurality of cutting-cooling non-deformable-effect compositions 1c:
A typical example related to the third embodiment shown in FIG. 4 will be described.
That is, as shown in FIG. 4, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supplying step: about 1 mm thick containing polyethylene terephthalate fiber, about 500 mm wide, about 300 mm long A holding member supplying step of supplying a non-woven holding member having flexibility and air humidity permeability, and (B) a fluid state capable of flowing at the first fluid temperature (about 40 ° C. to about 70 ° C.). The flow-effect composition raw material preparation step for preparing the B1 flow-effect composition raw material 11a is performed. The B1 fluidity effect composition raw material 11a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm to a thickness of about 1.5 mm. And (Ca) the said cooling effect composition raw material 11a is cooled to the 2nd cooling nondeformation temperature (about -10 degreeC-about 3 degreeC) which will be in a non-deformation state, and the non-deformation state cooling nondeformation effect composition A cooling step for forming 11b, and (D) a cooling non-deformation efficacy composition laminating step for laminating the cooling non-deformation efficacy composition 11b on the holding member 2 to prepare a holding member / cooling non-deformation efficacy composition laminate. (G) The holding member / cooling non-deformation effect composition laminate is laminated with the release protection member 3 to adjust the holding member / cooling non-deformation effect composition / peel protection member laminate, and then the holding member / Cooling non-deformable effect composition / peeling protection member laminate is cut into a predetermined shape (rectangular shape with a width of about 14 cm and a width of about 10 cm) to prepare a holding member / cutting cooling nondeformation effect composition / peeling protection member laminate Holding member, cooling non-deformable active composition Protective member laminate cutting step, and (E) raising the temperature of the holding member / cooling non-deformable effect composition laminate to the third non-flowing flexible temperature (about 20 ° C. to about 25 ° C.) The efficacy composition is changed from a cooling non-deformation state to a flexible efficacy composition 1 having no fluidity, and the flexibility efficacy composition 11 is adhered to the holding member 2 and the peel protection member 3 to thereby obtain the flexibility efficacy composition 1. Is provided with an effect composition softening adhesion laminating step for preparing a holding member / softening effect composition laminate structure / peeling protection member attached to the holding member 2. In this way, a rectangular holding member / flexible effect composition / peeling protective member laminate structure having a width of 14 cm, a length of 10 cm and a thickness of about 2.51 mm is obtained.
In addition, the obtained individual holding member / flexible effect composition / peeling protection member laminated structure is passed between two rolls having a spacing of about 2.5 mm, and the width is 14 cm, the width is 10 cm, and the thickness is about 2. It is also possible to prepare a 50 m rectangular holding member, a flexible effect composition, and a peel protection member laminated structure.
Thereby, the above-mentioned (effect D) operational effect is obtained.
In this way, a planar rectangular patch having a width of 14 cm, a length of 10 cm, and a thickness of about 2.5 mm is produced.

  In such a manufacturing process, at the time of cutting, the cooling non-deformation efficacy composition 11b does not flow, deforms, and is cut and accurately separated into the desired shape of the cooling non-deformation efficacy composition 11c. Obtained. That is, the cutting cooling non-deformation effect composition 11c having a desired shape with high accuracy in a desired thickness, area, shape, weight and the like was obtained. Moreover, deposits, such as a residue of a cooling nondeformation effect composition, were not recognized by the blade edge | tip of the press cutting blade type | mold 7 after cutting | disconnection operation | movement.

(Comparative Example 4)
On the other hand, the B1 fluid effect composition raw material 11a of about 40 ° C. to about 70 ° C. (first fluid temperature) obtained in the step (B) is about 20 ° C. to about 25 ° C. near room temperature. As a result of performing the same cutting operation as above using the cutting apparatus shown in FIG. 15 on the fluidity composition raw material at about 20 ° C. to about 25 ° C., the fluidity composition raw material is immediately deformed after the cutting operation. Again, the fluidity composition raw materials that were cut were mixed with each other and could not be cut accurately. In addition, after the cutting operation, a large amount of residue of the fluid effect composition raw material adhered to the cutting edge of the press cutting blade die 7.

(Typical Example 5)
Manufacture of a water-containing gel-like soft-acting composition patch comprising a plurality of kinds of effect compositions laminated in multiple layers:
A typical example related to Embodiment 4 shown in FIG. 5 will be described. That is, as shown in FIG. 5, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supply step: about 1 mm thick containing polyethylene terephthalate fiber etc., about 500 mm wide, about vertical A holding member supplying step for supplying a holding member 2 made of nonwoven fabric having 300 mm bending flexibility and air humidity permeability, (B) plural types of flow-effect composition raw materials (B1 composition raw materials 11a and B2 having different composition components from each other) A plurality of types of flow-effective composition raw material preparation steps for preparing the composition raw material 12a), wherein the B1 composition raw material 11a is the same as the B1 flow-effective composition raw material 11a prepared in the above-described exemplary embodiment 1-1. It was prepared as follows. Further, the B2 composition raw material 12a was prepared in the same manner as the B2 fluidity composition raw material 12a prepared in the above-described typical example 1-2. The B1 fluidity-efficiency composition raw material 11a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm so as to have a thickness of about 1.0 mm. The flow-effect composition raw material 12a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm to a thickness of about 0.5 mm. (C) The plurality of types of flow-efficiency composition raw materials 11a and 12a are cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) that is in a non-deformed state, and a plurality of types of non-deformed states are obtained. A cooling non-deformation effect composition (B1 cooling composition 11b and B2 cooling composition 12b) is formed, and then each of the plurality of types of cooling non-deformation effect compositions is formed in a plurality of predetermined shapes (about 14 cm in width, about A plurality of types of cooling non-deformation effect compositions cut into a predetermined shape for a plurality of types of cooling non-deformation effect compositions (B1 cutting cooling composition 11c and B2 cutting cooling composition 12c) A plurality of types of cutting cooling predetermined shape forming step, (D) a plurality of types of cutting cooling non-deformation effect compositions 11c and 12c are sequentially laminated in a multilayer on a predetermined surface of the holding member 2 Adhere A plurality of types of cutting cooling non-deformation efficacy composition lamination process for preparing a holding member and a plurality of types of cutting cooling non-deformation efficacy composition laminated structure, (G) a holding member and a plurality of types of cutting cooling non-deformation efficacy composition lamination configuration A peeling protection member laminating step of laminating the peeling protection member 3 on the object to adjust a holding member, a plurality of types of cutting cooling non-deformation efficacy composition, and a peeling protection member laminated structure, (E) the holding member A plurality of types of cutting cooling non-deformation efficacy compositions / peeling protection member laminated compositions are heated to a third non-flow softening temperature (about 20 ° C. to about 25 ° C.) While changing from a non-deformation state to a flexible state, the flexible effect compositions 11 and 12 in a flexible state in contact with the holding member are joined to the holding member 2, and a plurality of types of flexible effect compositions 11 and 12 are added. Bonded together and flexible Flexible efficacy compositions state comprises a potency compositions softening deposition lamination step of preparing the holding member, a plurality of types of flexible efficacy composition and peeling the protective member stack construct that is joined to the retaining member.
Further, the holding member, the multiple types of flexible effect composition, and the peeling protection member laminated structure formed by the above-described step (E) are cut and separated into a predetermined shape to obtain individual holding members, flexible effect compositions, and peeling. A patch composed of the protective member laminate composition is obtained. As the peeling protection member 3, a polyester (polyethylene terephthalate) film having a thickness of about 0.01 mm was used.
In this way, a flat rectangular patch having a width of about 14 cm, a length of about 10 cm, and a thickness of about 2.5 mm is obtained. In addition, the obtained individual holding member / flexible effect composition / peeling protection member laminated structure was passed between two rolls with a spacing of about 2.5 mm, and the width was 14 cm, the length was 10 cm, and the thickness was about 2.50 m. It is also possible to prepare a rectangular holding member / flexible effect composition / peeling protection member laminated structure.
Thereby, the above-mentioned effect (Effect E) can be obtained. Moreover, the patch obtained in this way has the above-mentioned effect (effect b). In particular, by making the thickness of the B2 composition raw material 12a having strong adhesive strength thinner than that of the B1 cutting cooling composition 11c having excellent cooling effect, such a patch is peeled off from the peeling protective member and applied to the human body. In this case, a patch having a strong adhesive force and an excellent cooling effect can be obtained.

  In such a manufacturing process, at the time of cutting, the cooling non-deformation active composition 11b, 12b is cut without being deformed without flowing, and the cooling non-deformation active composition having a desired shape accurately separated. 11c was obtained. That is, the cutting cooling non-deformation effect compositions 11c and 12c having a desired shape with high accuracy in a desired thickness, area, shape, weight, and the like were obtained. Moreover, deposits, such as a residue of a cooling nondeformation effect composition, were not recognized by the blade edge | tip of the press cutting blade type | mold 7 after cutting | disconnection operation | movement.

(Comparative Example 5)
On the other hand, the fluid effect composition raw materials 11a and 12a of about 40 ° C. to about 70 ° C. (first fluid temperature) obtained in the step (B) are about 20 ° C. to about 25 ° C. near room temperature. As a result of carrying out the same cutting operation as described above using the cutting apparatus shown in FIG. 15 for the fluid effect composition raw material at about 20 ° C. to about 25 ° C., the fluid effect composition raw material immediately flows after the cutting operation. Due to the deformation, the cut flow effect composition raw materials were mixed with each other and could not be cut accurately. In addition, after the cutting operation, a large amount of residue of the fluid effect composition raw material adhered to the cutting edge of the press cutting blade die 7.

(Typical Example 6)
Manufacture of other water-containing gel-like soft-acting composition patches comprising a plurality of types of effect compositions stacked in layers:
A typical example related to Embodiment 5 shown in FIG. 6 will be described.
That is, as shown in FIG. 6, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supply step: about 1 mm thick containing polyethylene terephthalate fiber etc., about 500 mm wide, about vertical A holding member supplying step for supplying a non-woven holding member 2 having 300 mm bending flexibility and air humidity permeability, (B) plural types of flow-effect composition raw materials (B3 composition raw materials 13a and B2 having different composition components from each other) A plurality of types of flow-effective composition raw material preparation steps for preparing the composition raw material 12a), wherein the B3 composition raw material 13a is the same as the B3 flow-effective composition raw material 13a prepared in the above-described exemplary embodiment 1-3. It was prepared as follows. Further, the B2 composition raw material 12a was prepared in the same manner as the B2 fluidity composition raw material 12a prepared in the above-described typical example 1-2. The B3 fluidity effect composition raw material 13a is poured into an acrylic resin (polymethyl methacrylate) container 30 cm long, 30 cm wide and 0.5 cm high to a thickness of about 1.0 mm, and the B2 The flow-effect composition raw material 12a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm to a thickness of about 0.5 mm.
(Ca) The plurality of types of flow-effect composition raw materials 13a, 12a are cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) at which they are in a non-deformed state. A cooling step for forming different types of cooling non-deformable efficacy compositions (B3 cooling composition 13b and B2 cooling composition 12b); (D) a plurality of types of cooling non-deformation efficacy compositions on a predetermined surface of the holding member 2; A plurality of types of cooling non-deformable effect composition laminating steps for sequentially stacking and adhering the objects 13b and 12b in multiple layers to prepare a holding member / multiple types of cooling non-deformation effect composition laminating composition, (G) holding member / multiple types A peeling protection member laminating step of laminating the peeling protection member 3 on the cooling non-deformation effect composition laminate structure of the above, and adjusting the holding member / multiple types of cooling non-deformation effect composition / release protection member lamination composition, (Cb) Holding member / multiple types The cooling non-deformation effect composition / peeling protection member laminated structure of the above is cut into a predetermined shape, and a holding member having a predetermined shape of the cut cooling non-deformation effect composition 13c, 12c. Holding member forming multiple layers of peel protection member, multiple types of cooling non-deformation efficacy composition, peeling protection member laminate configuration cutting step, (E) Holding member, multiple types of cooling non-deformation efficacy composition, peel protection The member laminated structure is heated to a third non-flow softening temperature (about 20 ° C. to about 25 ° C.), and the plurality of types of cut cooling non-deformation effect compositions are changed from a non-deformation state to a soft state, A flexible effect composition in a flexible state that is in contact with the holding member is bonded to the holding member, and a plurality of types of flexible effect compositions are bonded to each other so that the flexible effect composition 1 in the flexible state is bonded to the holding member 2. Holding member Efficacy composition softening deposition layering step of preparing a plurality of types of flexible efficacy composition and peeling the protective member stack arrangement comprising a.
As the peeling protection member 3, a polyester (polyethylene terephthalate) film having a thickness of about 0.01 mm was used.
In this way, a flat rectangular patch having a width of about 14 cm, a length of about 10 cm, and a thickness of about 2.5 mm is obtained. In addition, the obtained individual holding member / flexible effect composition / peeling protection member laminated structure was passed between two rolls with a spacing of about 2.5 mm, and the width was 14 cm, the length was 10 cm, and the thickness was about 2.50 m. It is also possible to prepare a rectangular holding member / flexible effect composition / peeling protection member laminated structure.
Thereby, the above-mentioned effect (Effect E) can be obtained. Moreover, the patch obtained in this way has the above-mentioned effect (effect b).
In particular, by making the thickness of the B2 flexible effect composition 12 having a strong adhesive strength thinner than that of the B3 flexible effect composition 13 having an excellent analgesic effect, such a patch is peeled off from the peeling protective member to the human body. When affixed, a patch having a strong adhesive force and an excellent analgesic effect can be obtained.

  In such a manufacturing process, at the time of cutting, the cooling non-deformation active composition 13b, 12b is cut without being flowed, deformed, and accurately separated into a desired shape. 13c and 12c were obtained. That is, the cutting cooling non-deformation efficacy compositions 13c and 12c having a desired shape with high accuracy in a desired thickness, area, shape, weight, and the like were obtained. Moreover, deposits, such as a residue of a cooling nondeformation effect composition, were not recognized by the blade edge | tip of the press cutting blade type | mold 7 after cutting | disconnection operation | movement.

(Comparative Example 6)
On the other hand, the fluid effect composition raw materials 13a and 12a of about 40 ° C. to about 70 ° C. (first fluid temperature) obtained in the step (B) are about 20 ° C. to about 25 ° C. near room temperature. The fluid effect composition raw material at about 20 ° C. was subjected to the same cutting operation as described above using the cutting apparatus shown in FIG. 15, and as a result, after the cutting operation, the fluid effect composition raw material immediately flow-deformed, Again, the cut fluidity composition raw materials were mixed together and could not be cut accurately. In addition, after the cutting operation, a large amount of residue of the fluid effect composition raw material adhered to the cutting edge of the press cutting blade die 7.

(Typical Example 7-a)
Manufacture of a water-containing gel-like soft active composition patch comprising a plurality of types of active compositions in a planar region:
A typical example related to Embodiment 6 shown in FIG. 7 will be described. That is, as shown in FIG. 7, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supply step: about 1 m thick containing polyethylene terephthalate fiber, etc., about 500 mm wide, about vertical A holding member supplying step for supplying a holding member 2 made of nonwoven fabric having 300 mm bending flexibility and air humidity permeability, (B) plural types of flow-effect composition raw materials (B1 composition raw materials 11a and B2 having different composition components from each other) A plurality of types of flow-effective composition raw material preparation steps for preparing the composition raw material 12a), wherein the B1 composition raw material 11a is the same as the B1 flow-effective composition raw material 11a prepared in the above-described exemplary embodiment 1-1. It was prepared as follows. Further, the B2 composition raw material 12a was prepared in the same manner as the B2 fluidity composition raw material 12a prepared in the above-described typical example 1-2. The B1 fluidity-efficiency composition raw material 11a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm so as to have a thickness of about 1.5 mm. The flow-effect composition raw material 12a is poured into an acrylic resin (polymethyl methacrylate) container having a height of 30 cm, a width of 30 cm, and a height of 0.5 cm so as to have a thickness of about 1.5 mm. (C) The plurality of types of flow-effect composition raw materials are cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) to be in a non-deformed state, and a plurality of types of cooling non-deformation in an undeformed state. The effect composition (B1 cooling composition 11b and B2 cooling composition 12b) is formed, and then the B1 cutting cooling composition 11c is cut into 10 cm in width and 10 cm in length, and the B2 cutting cooling composition 12c is cut into 2 cm in width and 10 cm in length. A plurality of types of cutting cooling non-deformation efficacy compositions (B1 cutting cooling composition 11c and B2 cutting cooling composition 12c) cut into their predetermined shapes, and a plurality of cutting cooling predetermined shapes Forming step (D) the plurality of types of cutting cooling non-deformation forming effect compositions 11c and 12c at predetermined positions in a planar region of a predetermined surface of the holding member 2 as shown in FIG. In the plane area A plurality of types of cutting and cooling non-deformable effect composition layering steps for preparing a holding member and a plurality of types of cutting and cooling non-deformation effect composition layered compositions, and (G) a holding member and a plurality of types of cutting. A peeling protection member laminating step for adjusting the holding member, a plurality of types of cutting cooling non-deformation efficacy composition / peeling protection member laminated composition by laminating the peeling protection member 3 on the cooling nondeformation efficacy composition laminated structure, and (E) The holding member, the plurality of types of cutting cooling non-deformation effect composition, and the peel protection member laminated composition are heated to a third non-flowing flexible temperature (about 20 to about 25 ° C.) to cut a plurality of types. The cooling non-deformable efficacy compositions 11c, 12c are changed from the non-deformed state to the flexible state, and the plurality of softened flexible effect compositions are joined to each other in the planar region and joined to the holding member 2 to obtain a plurality of types. Flexible efficacy composition 11 and 12 comprises a potency compositions softening deposition lamination step of preparing the holding member, a plurality of types of flexible efficacy composition and peeling the protective member stack construct that is bonded to the surface of the holding member 2.

As the peeling protection member 3, a polyester (polyethylene terephthalate) film having a thickness of about 0.01 mm was used.
In this way, a flat rectangular patch having a width of about 14 cm, a length of about 10 cm, and a thickness of about 2.5 mm is obtained. In addition, the obtained individual holding member / flexible effect composition / peeling protection member laminated structure was passed between two rolls with a spacing of about 2.5 mm, and the width was 14 cm, the length was 10 cm, and the thickness was about 2.50 m. It is also possible to prepare a rectangular holding member / flexible effect composition / peeling protection member laminated structure.
Thereby, the above-mentioned (effect) effect can be obtained. Further, the patch obtained in this way exhibits the above-mentioned effect (effect C).
In particular, by forming the B2 flexible effect composition 12 having a strong adhesive force and the B1 flexible effect composition 11 having an excellent cooling effect at a desired position, such a patch is peeled off from the release protection member and applied to the human body. In this case, a patch having a strong adhesive force and an excellent cooling effect can be obtained.
In this embodiment, a patch using the B3 fluid effect composition raw material 13a and the B4 fluid effect composition raw material 14a in place of the B2 fluid effect composition raw material 12a can also be implemented.

  In such a manufacturing process, at the time of cutting, the cooling non-deformation active composition 11b, 12b is cut without being deformed without flowing, and the cooling non-deformation active composition having a desired shape accurately separated. 11c was obtained. Moreover, after raising temperature to the third non-flow softening temperature (about 20 to about 25 ° C.), it was confirmed that the respective cutting cooling non-deformation efficacy compositions 11c and 12c were joined to each other. Thus, the cutting cooling non-deformation effect compositions 11c and 12c having a desired shape with high precision in a desired thickness, area, shape, weight, and the like were obtained. Moreover, deposits, such as a residue of a cooling nondeformation effect composition, were not recognized by the blade edge | tip of the press cutting blade type | mold 7 after cutting | disconnection operation | movement.

(Comparative Example 7-a)
On the other hand, the fluid effect composition raw materials 11a and 12a of about 40 ° C. to about 70 ° C. (first fluid temperature) obtained in the above-mentioned step (B) are left until they reach about 20 to 25 ° C. near room temperature. As a result of carrying out the same cutting operation as described above using the cutting device shown in FIG. 15 for the fluid effect composition raw material at about 20 ° C., the fluid effect composition raw material immediately flows and deforms after the cutting operation, The fluidity composition materials that were cut were mixed with each other and could not be cut accurately. In addition, after the cutting operation, a large amount of residue of the fluid effect composition raw material adhered to the cutting edge of the press cutting blade die 7.

(Typical Example 7-b)
Manufacture of a water-containing gel-like soft active composition patch comprising a plurality of types of active compositions in a planar region:
As another embodiment 6 similar to FIG. 7, another typical example relating to a patch comprising four kinds of flow-effect compositions will be described. That is, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supplying step: Flexibility flexibility of about 1 mm in thickness, about 500 mm in width and about 300 mm in length containing fibers made of polyethylene terephthalate, air A holding member supplying step for supplying a holding member 2 made of nonwoven fabric having moisture permeability, (B) plural types of flow-effect composition raw materials (B1 composition raw material 11a, B2 composition raw material 12a, B3 composition having mutually different composition components) A plurality of kinds of flow-effect composition raw material preparation steps for preparing a raw material 13a and a B4 composition raw material 12a), wherein the B1 composition raw material 11a, the B2 composition raw material 12a, the B3 composition raw material 13a, and the B4 composition raw material 14a Were prepared in the same manner as the raw materials for each fluidity composition prepared in the above-mentioned typical examples 1-1, 1-2, 1-3, and 1-4. The B1 fluidity composition composition 11a is poured into an acrylic resin (polymethylmethacrylate) container 30 cm long, 30 cm wide and 0.5 cm high to a thickness of about 1.5 mm, and the B3 fluidity composition The raw material 13a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm so as to have a thickness of about 1.5 mm. Pour into an acrylic resin (polymethylmethacrylate) container 30 cm wide, 30 cm wide and 0.5 cm high to a thickness of about 1.5 mm, and the B2 fluidity-effective composition raw material 12a is 30 cm long, horizontal Pour into an acrylic resin (polymethylmethacrylate) container 30 cm high and 1.5 cm high to a thickness of about 0.5 mm. (C) The plurality of types of flow-effect composition raw materials are cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) to be in a non-deformed state, and a plurality of types of cooling non-deformation in an undeformed state. Forming an effect composition (B1 cooling composition 11b, B2 cooling composition 12b, B3 cooling composition 13b, B4 cooling composition 14b), and then B1 fluid effect composition raw material 11a, B3 fluid effect composition raw material 13a, Each of the cooling non-deformable effect compositions of the B4 fluid effect composition raw material 14a is cut into a width of about 4 cm and a length of about 10 cm, and the B2 flow effect composition raw material 12a is cut into a width of about 1.0 cm and a length of about 10 cm, A plurality of cutting cooling non-deformation efficacy compositions (B1 cutting cooling composition 11c, B2 cutting cooling composition 12c, B3 cutting cooling composition 13c, B4 cutting) cut into a predetermined shape for a plurality of types of cooling non-deformation efficacy compositions A plurality of types, a plurality of cutting cooling predetermined shape forming steps for preparing the cooling composition 14c), and (D) each of the plurality of types of cutting cooling non-deformation at a predetermined position in a plane region of a predetermined surface of the holding member 2 As shown in FIG. 8C, the forming effect compositions 11c, 12c, 13c, and 14c are positioned so as to be adjacent to each other in the plane region, and a holding member and a plurality of types of cut cooling non-deformation effect composition laminated structures are formed. A plurality of types of cutting cooling non-deformation efficacy composition lamination step to be prepared, (G) a holding member and a plurality of types of cutting cooling non-deformation efficacy composition laminated structure, and a peeling protection member 3 is laminated on the holding member. A peeling protection member laminating step for adjusting the cutting cooling non-deformation effect composition / peeling protection member laminate composition, and (E) the holding member / multiple types of cutting cooling nondeformation effect composition / peeling protection member laminate composition The third non The temperature was raised to a dynamic softening temperature (about 20 ° C. to about 25 ° C.), and a plurality of types of cutting cooling non-deformation effect compositions 11c, 12c, 13c, and 14c were changed from the non-deformed state to the soft state, thereby being softened. A holding member in which a plurality of types of flexible effect compositions are bonded to each other in a planar region and bonded to the holding member 2, and the plurality of types of flexible effect compositions 11, 12, 13, 14 are bonded to the surface of the holding member 2. An effect composition softening adhesion laminating step for preparing a plurality of types of soft effect composition / peeling protective member laminate composition.

As the peeling protection member 3, a polyester (polyethylene terephthalate) film having a thickness of about 0.01 mm was used.
In this way, a flat rectangular patch having a width of about 14 cm, a length of about 10 cm, and a thickness of about 2.5 mm is obtained. In addition, the obtained individual holding member / flexible effect composition / peeling protection member laminated structure was passed between two rolls with a spacing of about 2.5 mm, and the width was 14 cm, the length was 10 cm, and the thickness was about 2.50 m. It is also possible to prepare a rectangular holding member / flexible effect composition / peeling protection member laminated structure.
Thereby, the above-mentioned (effect) effect can be obtained. Moreover, the patch obtained in this way has the above-mentioned effect (effect c).
In particular, the B2 flexible effect composition 12 having a strong adhesive force, the B1 soft effect composition 11 having an excellent cooling effect, the B3 soft effect composition 13 having an analgesic effect, and the B4 soft effect composition 14 having a refreshing feeling are in desired positions. By comprising, when such a patch is affixed to a human body after peeling off the peeling protection member, a patch having a strong adhesive force and an excellent cooling effect, analgesic effect, and cooling effect can be obtained.
In this embodiment, a patch using the B3 fluid effect composition raw material 13a and the B4 fluid effect composition raw material 14a in place of the B2 fluid effect composition raw material 12a can also be implemented.

  In such a manufacturing process, at the time of cutting, the cooling non-deformable effect compositions 11b, 12b, 13b, and 14b are not flowed, deformed, and cut and accurately separated into a desired shape. A deformable composition 11c was obtained. In addition, after raising the temperature to the third non-flow softening temperature (about 20 to about 25 ° C.), it is confirmed that the respective cutting cooling non-deformation effect compositions 11c, 12c, 13c, and 14c are joined to each other. did. Thus, the cutting cooling non-deformable effect compositions 11c, 12c, 13c, and 14c having a desired shape with high accuracy in a desired thickness, area, shape, weight, and the like were obtained. Moreover, deposits, such as a residue of a cooling nondeformation effect composition, were not recognized by the blade edge | tip of the press cutting blade type | mold 7 after cutting | disconnection operation | movement.

(Comparative Example 7-b)
On the other hand, the fluid effect composition raw materials 11a, 12a, 13a, and 14a of about 40 ° C. to about 70 ° C. (first fluid temperature) obtained in the above-described step (B) are about 20 ° C. to 25 ° C. near room temperature. As a result of performing the same cutting operation as described above using the cutting apparatus shown in FIG. 15 on the fluidity effect composition raw material at about 20 ° C, the fluidity effect composition raw material immediately flows and deforms after the cutting operation. Again, the fluidity composition raw materials that were cut were mixed with each other and could not be cut accurately. In addition, after the cutting operation, a large amount of residue of the fluid effect composition raw material adhered to the cutting edge of the press cutting blade die 7.

(Typical Example 8)
The production process of another hydrogel soft-acting composition patch of one embodiment of the present invention will be described:
A typical example related to Embodiment 7 shown in FIG. 9 will be described.
That is, as shown in FIG. 9, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supplying step: about 1 mm thick containing polyethylene terephthalate fiber etc., about 500 mm wide, about vertical A holding member supplying step of supplying a holding member 2 made of nonwoven fabric having 300 mm bending flexibility and air humidity permeability, and (B) a flowable state in the first flow temperature (about 40 ° C. to about 70 ° C.). Fluidity effect composition raw material preparation step for preparing the fluidity effect composition raw material 11a, wherein the B1 composition raw material 11a is the same as the B1 fluidity effect composition raw material 11a prepared in the above-described exemplary embodiment 1-1. The B1 fluidity-effective composition raw material 11a is placed in an acrylic resin (polymethyl methacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm to a thickness of about 1.5 mm. Pouring so.
(AB) Fluid effect composition laminating step of laminating the fluid effect composition raw material 11a on the holding member 2 to prepare a holding member / fluid effect composition raw material laminate composition, (ABC) the holding member / fluid effect The composition raw material laminated structure is cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) at which the fluid effect composition raw material 11a is in a non-deformed state, and the non-deformed state of cooling non-deformation effect The holding member / cooling non-deformation effect composition in which the composition 11b is formed is prepared, and then the B1 flow effect composition raw material 11a is cut into about 14 cm in width and about 10 cm in length to hold the holding member / cut cooling non-deformation effect composition. Cooling the predetermined shape forming step, and (E) raising the temperature of the holding member / cut cooling non-deformation effect composition laminate to the third non-flowing flexible temperature (about 20 to about 25 ° C.), Cutting cooling non-deformation effect composition 11c Changing from a cooling non-deformation state to a flexible effective composition 11 having no fluidity and attaching the flexible effective composition to the holding member, the flexible active composition adheres to the holding member. An effect composition softening adhesion laminating step for preparing an effect composition laminate composition.

(Typical Example 9)
The production process of another hydrogel soft-acting composition patch of one embodiment of the present invention will be described:
A typical example related to Embodiment 8 shown in FIG. 10 will be described. That is, as shown in FIG. 10, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supply step: about 1 mm thick containing polyethylene terephthalate fiber, etc., about 500 mm wide, about vertical A holding member supplying step of supplying a holding member 2 made of nonwoven fabric having 300 mm bending flexibility and air humidity permeability, and (B) a flowable state in the first flow temperature (about 40 ° C. to about 70 ° C.). Fluid efficacy composition raw material preparation step of preparing the fluid efficacy composition raw material 1a, wherein the B1 composition raw material 11a is the same as the B1 fluid efficacy composition raw material 11a prepared in the above-described exemplary embodiment 1-1. The B1 fluidity-effective composition raw material 11a is placed in an acrylic resin (polymethyl methacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm to a thickness of about 1.5 mm. Pouring so. (AB) Fluid effect composition laminating step of laminating the fluid effect composition raw material 11a on the holding member 2 to prepare a holding member / fluid effect composition raw material laminate composition, (ABC-a) the holding member / The fluidity-effective composition raw material laminated structure is cooled to a second cooling non-deformation temperature (about -10 ° C to about 3 ° C) at which the fluidity-efficiency composition raw material 11a is in a non-deformed state, thereby The holding member / cooling effect composition laminated structure in which the deformable effect composition 11b is formed is adjusted, and then (ABC-b) the peeling protection member 3 is placed on the holding member / cooling effect composition raw material laminated structure. Laminate to prepare a holding member / cooling effect composition / peeling protection member laminate composition, and then cut the holding member / cooling effect composition / peeling protection member laminate composition into a width of about 14 cm and a length of about 10 cm. Multiple holding members, cutting and cooling A plurality of cutting and cooling predetermined shape forming steps for preparing a shape-effect composition / peeling protection member laminate, (Ea) the plurality of holding members / cutting cooling non-deformation effect composition / peeling protection member laminate The temperature is raised to three non-flow softening temperatures (about 20 to about 25 ° C.) to change the cut cooling non-deformation active composition 11c from a cooling non-deformation state to a soft state with no fluidity. Efficacy of preparing a plurality of holding member / flexible effect composition / peeling protection member laminated structure in which the flexible effect composition 1 is attached to the holding member 2 and the flexible effect composition 1 is attached to the holding member 2. A composition softening adhesion lamination step.
As the peeling protection member 3, a polyester (polyethylene terephthalate) film having a thickness of about 0.01 mm was used.
In this way, a flat rectangular patch having a width of about 14 cm, a length of about 10 cm, and a thickness of about 2.5 mm is obtained. In addition, the obtained individual holding member / flexible effect composition / peeling protection member laminated structure was passed between two rolls with a spacing of about 2.5 mm, and the width was 14 cm, the length was 10 cm, and the thickness was about 2.50 m. It is also possible to prepare a rectangular holding member / flexible effect composition / peeling protection member laminated structure.

  In the manufacturing processes of the exemplary embodiments 8 and 9, when cut, the cooling non-deformable effect composition 11b is cut without being flowed, deformed, and precisely separated into a desired shape of cooling non-deformed. Efficacy composition 11c was obtained. That is, the cutting cooling non-deformation effect composition 11c having a desired shape with high accuracy in a desired thickness, area, shape, weight and the like was obtained. Moreover, deposits, such as a residue of a cooling nondeformation effect composition, were not recognized by the blade edge | tip of the press cutting blade type | mold 7 after cutting | disconnection operation | movement.

(Comparative Examples 8 and 9)
On the other hand, in typical Examples 8 and 9, the flow-effective composition raw material of about 40 ° C. to about 70 ° C. (first flow temperature) obtained in the above-mentioned step (B) is about 20 ° C. near room temperature. As a result of performing the same cutting operation as described above using the cutting apparatus shown in FIG. 15 on the fluidity composition composition raw material at about 20 ° C to 25 ° C, the fluidity composition was left after the cutting operation. The raw materials immediately flow-deformed, and the cut flow-efficiency composition raw materials were mixed again and could not be cut accurately. In addition, after the cutting operation, a large amount of residue of the fluid effect composition raw material adhered to the cutting edge of the press cutting blade die 7.

(Typical Example 10b)
A typical example for embodiment 9b will be described.
That is, as shown in FIG. 11, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supplying step: about 1 mm thick containing polyethylene terephthalate fiber etc., about 500 mm wide, about 300 mm long A holding member supplying step for supplying a non-woven holding member 2 having flexibility in bending and air humidity permeability, (F) an accommodation concave portion (about 14 cm wide, about 10 cm long, about 3 mm deep) opened on the upper surface, and A blister-type container supply step for supplying a blister-type container 4 made of polyester (polyethylene terephthalate) having a thickness of about 0.2 mm and a ridge formed at the periphery of the recess (AF) A holding member disposing step of adjusting the holding member disposing container by disposing the holding member in the concave portion of the blister type container 4; and (B) a plurality of types of flow effect compositions having different composition components. Plural kinds of flow-efficiency composition raw material preparation steps for preparing raw materials (B1 composition raw material 11a and B2 composition raw material 12a), wherein B1 composition raw material 11a was prepared in the above-described typical example 1-1. B1 fluid effect composition raw material 11a is prepared in the same manner, and B2 composition raw material 12a is prepared in the same manner as B2 fluid effect composition raw material 12a prepared in the above-described exemplary embodiment 1-2. The flow-efficiency composition raw material 11a is poured into an acrylic resin (polymethyl methacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm so as to have a thickness of about 1.0 mm. 12a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm so as to have a thickness of about 0.5 mm. (C) The plurality of types of flow-efficiency composition raw materials 11a and 12a are cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) that is in a non-deformed state, and a plurality of types of non-deformed states are obtained. A cooling non-deformable effect composition (B1 cooling composition 11b and B2 cooling composition 12b) is formed, and then the plurality of types of cooling non-deformation effect compositions are a predetermined number of about 14 cm in width and about 10 cm in length. A plurality of types of cooling non-deformation effect compositions cut into a shape (rectangle) and then cut into a predetermined shape (rectangle) for a plurality of types of cooling non-deformation effect compositions (B1 cutting cooling composition 11c and B2 cutting cooling) A plurality of types, a plurality of cutting and cooling predetermined shape forming steps for preparing the composition 12c), and (D) a plurality of types of cutting on the predetermined surface of the holding member 2 arranged in the concave portion of the blister type container material. Cooling unchanged A plurality of types of cutting / cooling non-deformation effect composition laminating steps for laminating and adhering the effect compositions 11c and 12c sequentially in multiple layers to prepare a holding member / a plurality of types of cutting / cooling non-deformation effect composition laminating composition, (G) Blister-type container material and holding member / multiple types of cutting / cooling non-deformation effect composition laminated structure 12c are covered with a peeling protection member 3 to form a holding member / multiple types of cutting / cooling non-deformation effect composition / Peeling protection member lamination step for adjusting the peeling protection member laminate composition, (E) The holding member, a plurality of types of cutting cooling non-deformation effect compositions, and the peeling protection member lamination composition are converted into a third non-flowing flexible temperature (about 20 to The temperature is raised to about 25 ° C., and the plurality of types of cutting cooling non-deformation efficacy compositions 11c, 12c are changed from the non-deformation state to the flexible state, and the flexible effect in the flexible state in contact with the holding member 2 is obtained. Compositions 11 and 12 While being bonded to the holding member 2, a plurality of types of flexible effect compositions are bonded to each other, and the peel protection member 3 is in close contact with the ridges of the blister container 4 while covering the plurality of types of flexible effect compositions 11, 12. The composition comprising a holding member, a plurality of types of softening composition, and a protective composition for peeling protection member are prepared.
As the peel protection member 3, a laminate film of polyester (polyethylene terephthalate) and polyethylene having a thickness of about 0.01 mm was used.
Further, in the step of installing and configuring the peeling protection member 3, the polyethylene layer side of the peeling protection member 3 can be thermally attached and sealed by pressure-bonding with the flange of the blister container in a heated state.
In this way, a flat rectangular patch having a width of about 14 cm, a length of about 10 cm, and a thickness of about 2.5 mm is obtained.
As a result, the above-described (effect) effect can be obtained. In addition, such a patch comprising a blister-type container has the above-mentioned effect (effect d).

(Typical Example 10c)
A typical example for embodiment 9c will be described.
That is, as shown in FIG. 12, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supplying step: about 1 mm thick containing polyethylene terephthalate fiber etc., about 500 mm wide, about 300 mm long A holding member supplying step for supplying a non-woven holding member 2 having flexibility in bending and air humidity permeability, (F) an accommodation concave portion (about 14 cm wide, about 10 cm long, about 3 mm deep) opened on the upper surface, and A blister-type container supply step for supplying a blister-type container 4 made of polyester (polyethylene terephthalate) having a thickness of about 0.2 mm and a ridge formed at the periphery of the recess (AF) A holding member disposing step of adjusting the holding member disposing container by disposing the holding member in the concave portion of the blister type container 4; and (B) a plurality of types of flow effect compositions having different composition components. Plural kinds of flow-efficiency composition raw material preparation steps for preparing raw materials (B1 composition raw material 11a and B2 composition raw material 12a), wherein B1 composition raw material 11a was prepared in the above-described typical example 1-1. B1 fluid effect composition raw material 11a is prepared in the same manner, and B2 composition raw material 12a is prepared in the same manner as B2 fluid effect composition raw material 12a prepared in the above-described exemplary embodiment 1-2. The flow-efficiency composition raw material 11a is poured into an acrylic resin (polymethyl methacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm so as to have a thickness of about 1.5 mm. 12a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 0.5 cm so as to have a thickness of about 1.5 mm. (C) The plurality of types of flow-efficiency composition raw materials 11a and 12a are cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) that is in a non-deformed state, and a plurality of types of non-deformed states are obtained. A cooling non-deformable effect composition (B1 cooling composition 11b and B2 cooling composition 12b) is formed, and then the B1 cut cooling composition 11c is cut to 10 cm in width and 10 cm in length, and the B2 cut cooling composition 12c is set to 2 cm in width. A plurality of cutting cooling non-deformation efficacy compositions 11b and 12b cut into a length of 10 cm and cut into a predetermined shape (B1 cutting cooling composition 11c and B2 cutting cooling composition 12c 8) A plurality of types, a plurality of cutting and cooling predetermined shape forming steps, and (D) a predetermined area of a planar area of a predetermined surface of the holding member 2 disposed in the concave portion of the blister type container 4 in FIG. Indicated) The plurality of types of cutting cooling non-deformation effect compositions 11c and 12c are positioned so as to be adjacent to each other in a planar region at a position such that a holding member and a plurality of types of cutting cooling non-deformation effect compositions are laminated. A plurality of types of cutting cooling non-deformation effect composition laminating step for preparing a product, (G) a holding member disposed in the ridge of the blister-type container 4 and the recess, and a plurality of types of cutting cooling non-deformation effect composition laminating composition The peeling protection member 3 is laminated on the holding member, a plurality of types of cutting cooling non-deformation effect compositions, and a peeling protection member lamination step for adjusting the peeling protection member lamination composition, and then (E) the holding member. -Multiple types of cutting cooling non-deformation efficacy composition-Peeling protection member laminated composition is heated to the third non-flow softening temperature (about 20 to about 25 ° C), and multiple types of cutting cooling non-deformation efficacy composition 11c , 12c undeformed By changing the state from the soft state to the soft state, the softened plural kinds of soft active compositions are joined to each other in the plane region and joined to the holding member 2, so that the plural kinds of soft active compositions 11, 12 are formed on the holding member 2. A holding member and a plurality of types of flexible effect compositions that are bonded to the surface and are in close contact with the ridges of the blister-type container 4 in a state where the peel protection member 3 covers a plurality of types of the flexible effect compositions 11 and 12. -Efficacy composition softening adhesion lamination process which prepares peeling protection member lamination composition.
As the peel protection member 3, a laminate film of polyester (polyethylene terephthalate) and polyethylene having a thickness of about 0.01 mm was used.
Further, in the step of installing and configuring the peeling protection member 3, the polyethylene layer side of the peeling protection member 3 can be thermally attached and sealed by pressure-bonding with the flange of the blister container in a heated state.
In this manner, a planar rectangular blister patch having a width of about 14 cm, a vertical width of about 10 cm, and a thickness of about 3 mm is obtained. As a result, the above-described (effect) effect can be obtained. In addition, such a patch comprising a blister-type container has the above-mentioned effect (effect d).
In this embodiment, a patch using the B3 fluid effect composition raw material 13a and the B4 fluid effect composition raw material 14a in place of the B2 fluid effect composition raw material 12a can also be implemented.

(Typical Example 10d)
As another typical example relating to Embodiment 9d, a blister-type patch comprising four types of flexible efficacy compositions will be described.
That is, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supplying step: Flexibility flexibility of about 1 mm in thickness, about 500 mm in width and about 300 mm in length containing fibers made of polyethylene terephthalate, air A holding member supplying step for supplying a holding member 2 made of nonwoven fabric having moisture permeability, (F) formed on a housing recess (opening about 14 cm in width, about 10 cm in length and about 3 mm in depth) opened on the upper surface and the periphery of the recess. A blister-type container supply step for supplying a blister-type container 4 made of polyester (polyethylene terephthalate) having a thickness of about 0.5 mm, and (AF) the blister-type container 4 A holding member arrangement step of adjusting the holding member arrangement container by arranging the holding member in the recess, (B) plural kinds of flow-effect composition raw materials (B1 composition having different composition components from each other) 11a, B2 composition raw material 12a, B3 composition raw material 13a, B4 composition raw material 14a) to prepare a plurality of types of fluid effect composition raw material preparation steps, wherein B1 composition raw material 11a, B2 composition raw material 12a, The B3 composition raw material 13a and the B4 composition raw material 14a are prepared in the same manner as the respective fluid effect composition raw materials prepared in the above-described typical examples 1-1, 1-2, 1-3, and 1-4. B1 fluidity effect composition raw material 11a, B3 fluidity effect composition raw material 13a, and B4 fluidity effect composition raw material 14a are each made of acrylic resin having a height of 30 cm, a width of 30 cm, and a height of 0.5 cm. (Polymethylmethacrylate) poured into a container made to a thickness of about 1.5 mm, and B2 fluidity composition raw material 12a is 30 cm long, 30 cm wide, 0 height 5cm poured to a thickness of about 1.5mm in the acrylic resin (polymethyl methacrylate) manufactured container. (C) The plurality of types of flow-effect composition raw materials 11a, 12a, 13a, and 14a are cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) to be in an undeformed state. A plurality of types of cooling non-deformable effect compositions (B1 cooling composition 11b, B2 cooling composition 12b, B3 cooling composition 13b, B4 cooling composition 14b), and flow effect composition raw materials 11a, 13a, 14a Cut into about 4 cm in width and about 10 cm in length, and cut the flow-effect composition raw material 12a into about 1 cm in width and about 10 cm in length to form a plurality of types of cooling non-deformation effect compositions 11b, 12b, 13b, and 14b in a predetermined shape. Plural kinds of preparing a plurality of cut cooling non-deformable effect compositions (B1 cutting cooling composition 11, B2 cutting cooling composition 12c, B3 cutting cooling composition 13, B4 cutting cooling composition 14c) Several-cut cooling a predetermined shape forming step,
(D) Each of the plurality of types of cutting, cooling, and non-deformation is formed at predetermined positions as shown in FIG. 8C in a planar area of a predetermined surface of the holding member 2 disposed in the concave portion of the blister container 4. A plurality of types of cutting cooling non-deformation efficacy for preparing a holding member and a plurality of types of cutting cooling non-deformation efficacy composition laminated composition by positioning the efficacy compositions 11c, 12c, 13c, 14c adjacent to each other in a plane region Composition stacking step, (G) holding member in which peeling protection member 3 is laminated on the ridge of blister container 4 and the holding member arranged in the concave portion / multiple types of cutting cooling non-deformation effect composition laminated structure -A plurality of types of cutting cooling non-deformation efficacy compositions-A peeling protection member lamination step for adjusting a peeling protection member laminate composition, and then (E) the holding member-a plurality of types of cutting cooling non-deformation efficacy compositions- Peeling protection material volume The composition is heated to the third non-flow softening temperature (about 20 to about 25 ° C.), and the plurality of types of cutting cooling non-deformation efficacy compositions 11c, 12c, 13c, and 14c are changed from the non-deformation state to the soft state. Then, the plurality of kinds of softened flexible effect compositions are joined to each other in a plane region and joined to the holding member 2, so that the plurality of kinds of flexible effect compositions 11, 12, 13, and 14 are joined to the surface of the holding member 2. In addition, a holding member configured to be in close contact with the ridge of the blister container 4 in a state in which the peel protection member 3 covers a plurality of types of flexible effect compositions 11, 12, 13, and 14. An effect composition softening adhesion laminating step for preparing an object / peeling protection member laminating composition is provided.
As the peel protection member 3, a laminate film of polyester (polyethylene terephthalate) and polyethylene having a thickness of about 0.01 mm was used.
Further, in the step of installing and configuring the peeling protection member 3, the polyethylene layer side of the peeling protection member 3 can be thermally attached and sealed by pressure-bonding with the flange of the blister container in a heated state.
In this manner, a planar rectangular blister patch having a width of about 14 cm, a vertical width of about 10 cm, and a thickness of about 3 mm is obtained.
Thereby, while having the analgesic effect, the cooling effect, and the cooling effect, the effect which has the outstanding adhesive force to a human body skin is obtained, and the effect of the above-mentioned (effect G) is acquired. In addition, such a patch comprising a blister-type container has the above-mentioned effect (effect d).

(Typical Example 10e)
A typical example for embodiment 9e will be described.
That is, as shown in FIG. 13, the manufacturing method of the patch of one embodiment of the present invention is as follows. (A) Holding member supply step: about 1 mm thick containing polyethylene terephthalate fiber etc., about 500 mm wide, about 300 mm long A holding member supplying step for supplying a non-woven holding member 2 having flexibility in bending and air humidity permeability, (F) an accommodation concave portion (about 14 cm wide, about 10 cm long, about 3 mm deep) opened on the upper surface, and A blister-type container supply step for supplying a blister-type container 4 made of polyester (polyethylene terephthalate) having a thickness of about 0.2 mm and a ridge formed on the periphery of the recess (B) A plurality of types of fluid effect composition raw material preparation steps for preparing a plurality of types of fluid effect composition raw materials (B1 composition raw material 11a and B2 composition raw material 12a) having different composition components, The B1 composition raw material 11a is prepared in the same manner as the B1 flow effect composition raw material 11a prepared in the above-described typical example 1-1, and the B2 composition raw material 12a is prepared in the above-described typical example 1- 2 is prepared in the same manner as the B2 fluidity composition raw material 12a prepared in step 2.
(I) Exemplary Embodiment 10e-i
Using these flow-efficiency composition raw materials, the plurality of types of cutting-cooling non-deformation-forming effect compositions 11c and 12c are attached to each other at a predetermined position in a plane region of a predetermined surface of the concave portion of the blister-type container 4. A plurality of types of cutting cooling non-deformation effect composition laminating steps for preparing a holding member and a plurality of types of cutting cooling non-deformation effect composition laminating composition positioned adjacent to the planar region will be described.
B1 flow effect composition raw material 11a is poured into an acrylic resin (polymethyl methacrylate) container 30 cm long, 30 cm wide and 0.5 cm high to a thickness of about 1.5 mm, and B2 flow effect The composition raw material 12a is poured into an acrylic resin (polymethyl methacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 1.5 cm so as to have a thickness of about 1.5 mm.
(C) The plurality of types of flow-efficiency composition raw materials 11a and 12a are cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) that is in a non-deformed state, and a plurality of types of non-deformed states are obtained. Cooling non-deformable effect compositions (B1 cooling composition and B2 cooling composition) 11b, 12b are formed, and then each of the plural types of cooling non-deformation effect compositions is formed into a plurality of predetermined shapes 7 cm wide and 10 cm long. A plurality of types of cooling non-deformation effect compositions 11b and 12b are cut to prepare a plurality of cutting cooling non-deformation effect compositions (B1 cutting cooling composition 11c and B2 cutting cooling composition 12c). A plurality of types, a plurality of cutting cooling predetermined shape forming steps, (D) (i) each of the plurality of types of cutting cooling non-deformation formation at a predetermined position in a plane area of a predetermined surface of the concave portion of the blister type container 4 Efficacy composition 11c and 12c are positioned so as to be adjacent to each other in the plane region, and a plurality of types of cutting cooling non-deformation effect composition laminating step of preparing a holding member and a plurality of types of cutting cooling non-deformation effect composition laminating composition, (AF ) A holding member arrangement step of adjusting the holding member arrangement container by arranging the holding member 2 on the cutting cooling non-deformation forming effect composition 11c, 12c arranged in the concave portion of the blister type container 4, (G) The holding member / multiple types of cutting / cooling non-deformation is formed by laminating the peeling protection member 3 on the holding member / multiple types of cutting / cooling non-deformation effect composition laminated structure arranged in the blister type container 4 and the recess. After the peeling protection member laminating step for adjusting the efficacy composition / peeling protection member laminate composition, (E) the holding member / multiple types of cutting cooling non-deformation efficacy composition / peeling protection member lamination composition Three Heating up to a dynamic softening temperature (about 20 ° C. to about 25 ° C.) and changing a plurality of types of cutting cooling non-deformation effect compositions 11c and 12c from a non-deformed state into a flexible state, thereby making them flexible. The effect compositions are joined to each other in a plane region and joined to the holding member 2, and a plurality of types of flexible efficacy compositions 11 and 12 are joined to the surface of the holding member 2, and the peeling protection member 3 attaches the holding member 2. An effect composition softening adhesion laminating step for preparing a holding member, a plurality of types of softening effect compositions, and a peel protection member laminated structure that is configured to be in close contact with the blister of the blister type container 4 in a covered state. In this manner, a planar rectangular blister patch having a width of about 14 cm, a vertical width of about 10 cm, and a thickness of about 3 mm is obtained.

(Ii) Exemplary Embodiment 10e-ii
Using these flow-effect composition raw materials, the blister-type container 4 is laminated in a thickness direction on a predetermined surface of the concave portion, and the plurality of types of cut cooling non-deformation forming effect compositions 11c and 12c are obtained. A plurality of types of cutting cooling non-deformation efficacy composition lamination steps for preparing a holding member and a plurality of types of cutting cooling non-deformation efficacy composition lamination components will be described.
B1 flow effect composition raw material 11a is poured into an acrylic resin (polymethylmethacrylate) container 30 cm long, 30 cm wide and 0.5 cm high to a thickness of about 1.0 mm, and B2 flow effect The composition raw material 12a is poured into an acrylic resin (polymethylmethacrylate) container having a length of 30 cm, a width of 30 cm, and a height of 1.5 cm so as to have a thickness of about 0.5 mm.
(C) The plurality of types of flow-efficiency composition raw materials 11a and 12a are cooled to a second cooling non-deformation temperature (about −10 ° C. to about 3 ° C.) at which they are in a non-deformed state, Cooling non-deformation effect compositions (B1 cooling composition and B2 cooling composition) 11b and 12b are formed, and then the plurality of types of cooling non-deformation effect compositions are formed into a plurality of predetermined shapes of 14 cm in width and 10 cm in length. A plurality of types of cooling non-deformation effect compositions 11b and 12b are cut to prepare a plurality of cutting cooling non-deformation effect compositions (B1 cutting cooling composition 11c and B2 cutting cooling composition 12c). (D) (ii) The plurality of types of cutting cooling non-deformation forming effect compositions 11c and 12c are sequentially formed in multiple layers in the concave portion of the blister type container 4. A plurality of types of cutting and cooling non-deformable effect composition stacking steps for preparing a holding member and a plurality of types of cutting and cooling non-deformation effect composition layered compositions, and (AF) disposed in the concave portion of the blister type container 4 A holding member arrangement step of adjusting the holding member arrangement container by arranging the holding member 2 on the cut cooling non-deformation forming effect composition 11c, 12c, and (G) arranged in the ridge and the recess of the blister type container 4 The peeling protection member 3 is laminated on the holding member / multiple types of cutting cooling non-deformation effect composition laminated structure to prepare the holding member / multiple types of cutting cooling non-deformation effect composition / peel protection member laminated composition The peeling protection member laminating step is performed, and then (E) the holding member, a plurality of types of cutting cooling non-deformation efficacy composition, and the peeling protection member laminating composition are transferred to a third non-flowing flexible temperature (about 20 ° C. to about 25 ℃) By changing the types of cutting cooling non-deformable effect compositions 11c, 12c from the non-deformed state to the flexible state, the softened multiple types of flexible effect compositions are joined to each other in the planar region and joined to the holding member 2, A holding member formed by adhering a plurality of types of flexible effect compositions 11 and 12 to the surface of the holding member 2 and in close contact with the ridge of the blister type container 4 with the peeling protection member 3 covering the holding member 2 -It has the effect composition softening adhesion lamination process which prepares multiple types of flexible effect composition and peeling protection member laminated structure. In this manner, a planar rectangular blister patch having a width of about 14 cm, a vertical width of about 10 cm, and a thickness of about 3 mm is obtained.
As the peel protection member 3, a laminate film of polyester (polyethylene terephthalate) and polyethylene having a thickness of about 0.01 mm was used.
Further, in the step of installing and configuring the peeling protection member 3, the polyethylene layer side of the peeling protection member 3 can be thermally attached and sealed by pressure-bonding with the flange of the blister container in a heated state.
Thereby, while obtaining the patch which shows the outstanding cooling effect and strong adhesive force, the effect of the above-mentioned (effect G) is obtained. In addition, such a patch comprising a blister-type container has the above-mentioned effect (effect d).

(Typical Example 10f)
A typical example related to Embodiment 9f will be described.
That is, as shown in FIG. 14, the method for producing a patch of one embodiment of the present invention is the same as the above-described exemplary embodiments 10b, 10c, 10d, and 10e (G).・ Installing the peeling protection member in a state where the other surface of the cutting cooling non-deformation effect composition and the blister of the blister container are covered, and the holding member / cutting cooling non-deformation effect composition laminate from atmospheric pressure The peeling protection member and the blister-type container are joined in a state where the pressure is reduced to a reduced pressure state, thereby providing a sealing step of preparing a reduced pressure sealed package.
In this way, a blister-type patch having a predetermined shape is obtained.
Thereby, the effect of significantly reducing bubbles remaining in the flexible effect composition, the effect of further improving the bondability between the holding member and the flexible effect composition, and the effect of improving the long-term storage by suppressing the oxidative degradation The above-mentioned (effect H) effects can be obtained.

In the manufacturing process of exemplary embodiments 10b to 10f, upon cutting, the cooling non-deformable efficacy compositions 11b, 12b, 13b, 14b are cut and accurately separated without flow, without deformation, and without separation. Cooling non-deformable efficacy compositions 11c, 12c, 13c, and 14c having the following shape were obtained. In addition, the plurality of types of flexible effect compositions 11, 12, 13, and 14 arranged at predetermined positions were bonded to each other and bonded to the surface of the holding member 2.
That is, flexible effect compositions 11, 12, 13, and 14 having desired shapes with high accuracy in desired thickness, area, shape, weight, and the like were obtained. In addition, in the configuration using a plurality of types of soft-effect compositions, a patch with a desired shape with high accuracy in thickness, area, shape, etc. as designed was obtained. Moreover, deposits, such as a residue of a cooling nondeformation effect composition, were not recognized by the blade edge | tip of the press cutting blade type | mold 7 after cutting | disconnection operation | movement.

(Comparative Example 10)
On the other hand, in typical Examples 10b to 10f, the fluid effect composition raw materials 11a, 12a, 13a, and 14a of about 40 ° C. to about 70 ° C. (first fluid temperature) obtained in the step (B) described above. Is allowed to stand at about 20 ° C. to 25 ° C. near room temperature, and each of the fluid effect composition raw materials 11a, 12a, 13a, and 14a at about 20 ° C. to 25 ° C. is converted into the above using a cutting apparatus shown in FIG. As a result of carrying out the same cutting operation, after the cutting operation, the fluid effect composition raw material immediately flow-deformed, and the cut fluid effect composition raw materials were mixed again and could not be cut accurately. In addition, after the cutting operation, a large amount of residue of the fluid effect composition raw material adhered to the cutting edge of the press cutting blade die 7.

  According to the present invention, at the time of cutting, the cooling non-deformation efficacy composition is cut without being deformed without being deformed, and a cooling non-deformation efficacy composition having a desired shape is obtained. As a result, it is possible to obtain a method for producing a patch and a patch that can form the active composition on the surface of the holding member with high accuracy in thickness, area, shape, lamination position, and the like. Further, according to the present invention, when a flexible effect composition is cut into a desired shape using a normal press cutting blade mold, the residue of the flexible effect composition after the cutting operation adheres to the cutting edge of the press cutting blade mold. A method for producing a patch and a patch that can be suppressed are obtained.

DESCRIPTION OF SYMBOLS 1 Flexible effect composition 1a Flow effect composition raw material 1b Cooling non-deformation effect composition 1c Cutting cooling non-deformation effect composition 2 Holding member 3 Peeling protection member 4 Blister type container 7 Pressing blade type 8 Blade type attachment of flat plate type cutting device Panel 9 Receptacle of flat plate cutting device 11 Flexible effect composition 11a B1 fluidity effect composition raw material 11b B1 cooling non-deformation effect composition 11c B1 cutting cooling nondeformation effect composition 12 B2 flexible effect composition 12a B2 fluid effect composition Raw material 12b B2 cooling non-deformation efficacy composition 12c B2 cutting cooling non-deformation efficacy composition 13 B3 flexible efficacy composition 14 B4 flexible efficacy composition

Claims (18)

Comprising at least a flexible effect composition having a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition,
The flexible effect composition has a flow state capable of flowing at a first flow temperature, can be cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed so as not to be deformed at the time of cutting. Having a flexible state with no fluidity at a third non-flowing flexible temperature having raised the second cooling non-deformation temperature,
The flexible effect composition is a method for producing a patch, which is produced by a step comprising a step of being formed into a predetermined shape while being cooled to the second cooling non-deformation temperature,
(A) a holding member supply step for supplying a holding member;
(B) A fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a fluid state capable of flowing at the first fluid temperature,
(C) The fluidity-effective composition raw material is cooled to a second cooling non-deformation temperature at which the fluidity-effective composition raw material is brought into an undeformed state to form an undeformed cooled non-deformable effect composition. Cooling predetermined shape forming step of preparing a cut cooling non-deformation effect composition by cutting into a shape,
(D) a cooling non-deformation effect composition laminating step of laminating the cutting cooling non-deformation effect composition on the holding member to prepare a holding member / cut cooling non-deformation effect composition laminate; and
(E) The holding member / cutting cooling non-deformation effect composition laminate is heated to the third non-flowing flexible temperature, and the cutting cooling non-deformation effect composition is changed from a cooling non-deformation state to a flexible state without fluidity. An effect composition for preparing a holding member / flexible effect composition laminated composition in which the flexible effect composition is attached to the holding member by changing the soft effect composition to the holding member. Softening lamination process,
A method for producing a patch, comprising: Comprising at least a flexible effect composition having a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition,
The flexible effect composition has a flow state capable of flowing at a first flow temperature, can be cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed so as not to be deformed at the time of cutting. Having a flexible state with no fluidity at a third non-flowing flexible temperature having raised the second cooling non-deformation temperature,
The flexible effect composition is a method for producing a patch, which is produced by a step comprising a step of being formed into a predetermined shape while being cooled to the second cooling non-deformation temperature,
(A) a holding member supply step for supplying a holding member;
(B) A fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a fluid state capable of flowing at the first fluid temperature,
(C) The fluidity-effective composition raw material is cooled to a second cooling non-deformation temperature at which the fluidity-effective composition raw material is brought into an undeformed state to form an undeformed cooled non-deformable effect composition. Cooling predetermined shape forming step of preparing a plurality of cutting cooling non-deformation efficacy composition by cutting into a predetermined shape
(D) A plurality of the plurality of cutting cooling non-deformation efficacy compositions laminated and adhered to a predetermined surface region of the holding member to prepare a holding member and a plurality of cutting cooling non-deformation efficacy composition laminated components. A cooling non-deformation effect composition laminating step, and
(E) The holding member and the plurality of cutting cooling non-deformation effect composition layered components are heated to a third non-flow softening temperature, and the plurality of cutting cooling non-deformation effect compositions are softened from an undeformed state. A flexible effect composition that is changed into a state and softened is attached to the holding member to prepare a holding member in which the flexible effect composition in a flexible state is attached to the holding member. Active composition softening adhesion lamination process,
A method for producing a patch, comprising: Comprising at least a flexible effect composition having a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition,
The flexible effect composition has a flow state capable of flowing at a first flow temperature, can be cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed so as not to be deformed at the time of cutting. Having a flexible state with no fluidity at a third non-flowing flexible temperature having raised the second cooling non-deformation temperature,
The flexible effect composition is a method for producing a patch, which is produced by a step comprising a step of being formed into a predetermined shape while being cooled to the second cooling non-deformation temperature,
(A) a holding member supply step for supplying a holding member;
(B) a plurality of types of fluid effect composition raw material preparation steps for preparing a plurality of types of fluid effect composition raw materials having different composition components from each other;
(C) cooling each of the plurality of types of flow-efficiency composition raw materials to a second cooling non-deformation temperature that is in an undeformed state to form a plurality of types of non-deformable cooling non-deformation effect compositions; A plurality of types of cooling non-deformation efficacy compositions are cut into a plurality of predetermined shapes, and a plurality of types of cooling non-deformation efficacy compositions are cut into predetermined shapes for the plurality of types of cooling non-deformation efficacy compositions. Multiple types / multiple / cut cooling predetermined shape forming process to be prepared,
(D) The plurality of types of cutting cooling non-deformation efficacy compositions are sequentially laminated in a multilayer on a predetermined surface of the holding member, and the holding member / multiple types of cutting cooling non-deformation efficacy composition laminated composition A plurality of types of cutting cooling non-deformation effect composition laminating steps to be prepared, and
(E) Raising the holding member / multiple types of cutting cooling non-deformation efficacy composition layered composition to a third non-flowing flexible temperature to soften the multiple types of cutting cooling non-deformation efficacy composition from an undeformed state The flexible effect composition in a flexible state in which the flexible effect composition in contact with the holding member is joined to the holding member and a plurality of types of flexible effect compositions are joined to each other. An effect composition softening adhesion laminating step for preparing a holding member and a plurality of types of softening effect composition laminate structures bonded to the holding member,
A method for producing a patch, comprising: Comprising at least a flexible effect composition having a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition,
The flexible effect composition has a flow state capable of flowing at a first flow temperature, can be cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed so as not to be deformed at the time of cutting. Having a flexible state with no fluidity at a third non-flowing flexible temperature having raised the second cooling non-deformation temperature,
The flexible effect composition is a method for producing a patch, which is produced by a step comprising a step of being formed into a predetermined shape while being cooled to the second cooling non-deformation temperature,
(A) a holding member supply step for supplying a holding member;
(B) a plurality of types of fluid effect composition raw material preparation steps for preparing a plurality of types of fluid effect composition raw materials having different composition components from each other;
(C) cooling each of the plurality of types of flow-efficiency composition raw materials to a second cooling non-deformation temperature that is in an undeformed state to form a plurality of types of non-deformable cooling non-deformation effect compositions; A plurality of types of cooling non-deformation efficacy compositions are cut into a plurality of predetermined shapes, and a plurality of types of cooling non-deformation efficacy compositions are prepared into a plurality of types of cooling non-deformation efficacy compositions cut into a predetermined shape. Multiple types, multiple, cutting and cooling predetermined shape forming process,
(D) The plurality of types of cutting cooling non-deformation forming effect compositions are positioned adjacent to each other in a plane area of a plane area of a predetermined surface of the holding member, A plurality of types of cutting cooling non-deformation effect composition laminating steps for preparing a cutting cooling non-deformation effect composition laminating composition, and
(E) Raising the holding member / multiple types of cutting cooling non-deformation efficacy composition layered composition to a third non-flowing flexible temperature to soften the multiple types of cutting cooling non-deformation efficacy composition from an undeformed state A plurality of types of softened flexible composition that are changed into a state are bonded to each other in a planar region and bonded to the holding member, and the multiple types of softened composition are bonded to the surface of the holding member. Efficacy composition softening adhesion laminating step to prepare a member / multiple types of softness effect composition laminate composition,
A method for producing a patch, comprising: Comprising at least a flexible effect composition having a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition,
The flexible efficacy composition has a flowable fluid state at a first flow temperature, undeformed so as not to deform during cutting with a cleavable under the second cooling undeformed temperature of a temperature lower than the first stream dynamic temperature Having a flexible state with no fluidity at a third non-flowing flexible temperature having raised the second cooling non-deformation temperature,
The flexible effect composition is a method for producing a patch, which is produced by a step comprising a step of being formed into a predetermined shape while being cooled to the second cooling non-deformation temperature,
(A) a holding member supply step for supplying a holding member;
(B) A fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a fluid state capable of flowing at the first fluid temperature,
(AB) A fluid effect composition laminating step of laminating the fluid effect composition raw material on the holding member to prepare a retaining member / fluid effect composition raw material laminate composition,
(ABC) The holding member / fluid effect composition raw material laminated structure is cooled to a second cooling non-deformation temperature at which the fluid effect composition raw material is in a non-deformable state, and a non-deformed cooled non-deformable effect composition The holding member / cooling non-deformation active composition is formed, and then the holding member / cooling non-deformation active composition is cut into a predetermined shape to prepare the holding member / cut cooling non-deformation active composition Shape forming step, and
(E) The holding member / cutting cooling non-deformation effect composition laminate is heated to the third non-flowing flexible temperature, and the cutting cooling non-deformation effect composition is changed from a cooling non-deformation state to a flexible state without fluidity. An effect composition for preparing a holding member / flexible effect composition laminated composition in which the flexible effect composition is attached to the holding member by changing the soft effect composition to the holding member. Softening lamination process,
A method for producing a patch, comprising: Comprising at least a flexible effect composition having a plurality of composition components and having an effect, and a holding member that is bonded to one surface of the flexible effect composition and holds the flexible effect composition,
The flexible effect composition has a flow state capable of flowing at a first flow temperature, can be cut at a second cooling non-deformation temperature lower than the first flow temperature, and is not deformed so as not to be deformed at the time of cutting. Having a flexible state with no fluidity at a third non-flowing flexible temperature having raised the second cooling non-deformation temperature,
The flexible effect composition is a method for producing a patch, which is produced by a step comprising a step of being formed into a predetermined shape while being cooled to the second cooling non-deformation temperature,
(A) a holding member supply step for supplying a holding member;
(B) A fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a fluid state capable of flowing at the first fluid temperature,
(AB) A fluid effect composition laminating step of laminating the fluid effect composition raw material on the holding member to prepare a retaining member / fluid effect composition raw material laminate composition,
(ABC-a) The holding member / fluid effect composition raw material laminated structure is cooled to a second cooling non-deformation temperature at which the fluid effect composition raw material is in a non-deformed state, and the non-deformed state of the cooling non-deformation effect is obtained. The holding member / cooling effect composition laminate structure formed with the composition is adjusted, and then the holding member / cooling effect composition laminate composition is cut into a plurality of predetermined shapes to be a plurality of holding members / cut cooling. A plurality of cutting and cooling predetermined shape forming steps for preparing a non-deformable effect composition,
(Ea) The plurality of holding members / cutting cooling non-deformation effect composition laminate is heated to the third non-flowing flexible temperature, and the cutting cooling non-deformation effect composition is flowed from the cooling non-deformation state. A plurality of holding members / flexible effect compositions laminated with the flexible effect composition attached to the holding member. Efficacy composition softening adhesion lamination process to prepare the composition,
A method for producing a patch, comprising: further,
(F) a blister-type container supply step for supplying a blister-type container having an accommodation recess opened on the upper surface and a ridge formed at the periphery of the recess; and (AF) placing the holding member in the recess of the blister-type container A holding member arrangement step of arranging and adjusting the holding member arrangement container,
Through the (B) fluidity effect composition raw material preparation step and the (C) cooling predetermined shape forming step,
In the (D) cooling non-deformation effect composition laminating step, the cutting cooling non-deformation effect composition is laminated on the holding member disposed in the recess of the blister type container material, and the holding member / cut cooling non-deformation effect is obtained. Preparing a composition;
Then, the manufacturing method of the patch in any one of the Claims 1 thru | or 4 which pass through the said (E) effect composition softening adhesion | attachment lamination process. Furthermore, on the other side of the flexible effect composition is a method for producing a patch comprising a peel protection member that is peeled off during use,
(Ga) A peeling protection member supplying step for supplying the peeling protection member, and
(Gb) After the (D) cooling non-deformation efficacy composition laminating step, the peeling protection member is laminated on the other surface of the cooling non-deformation efficacy composition to hold the holding member / cooling non-deformation efficacy composition / peeling Peeling member laminating step for preparing a protective member laminating composition, or
Peeling to prepare a holding member / flexible efficacy composition / peeling protection member laminated structure by laminating the peeling protection member on the other surface of the flexible efficacy composition after the (E) efficacy composition softening adhesion laminating step Member lamination process,
The method for producing a patch according to any one of claims 1 to 7 , further comprising: Furthermore, it is a method for producing a patch provided with a peel protection member that is peeled off during use,
further,
(Ga) A peeling protection member supplying step for supplying the peeling protection member, and
(Gb) While installing the peeling protection member in a state of covering the other surface of the holding member / cutting cooling non-deformation effect composition and the blister of the blister type container, the holding member / cutting cooling non-deformation effect In a state where the composition laminate is depressurized so as to be depressurized from the atmospheric pressure, a sealing step of joining the peeling protection member and the blister of the blister type container to thereby prepare a vacuum sealed package comprising, a manufacturing method of a patch according to claim 7, characterized in that. (B) In the fluid effect composition raw material preparation step, the fluid effect composition raw material contains at least water and a water-soluble polymer containing water, and is in a fluid state capable of flowing at the first fluid temperature, It becomes a non-deformable state that can be cut as it becomes lower than the first flow temperature and does not deform at the time of cutting, and is a hydrous gel that does not flow when processed from the non-deformation state to the third non-flow soft temperature having properties becomes soft efficacy compositions, method for producing a patch according to any one of claims 1 to 9, characterized in that. The method for producing a patch according to any one of claims 1 to 10 , which exhibits a cooling effect or a cooling sensation effect when applied to the skin of a human body. The fluid effect composition raw material or the flexible effect composition further contains a medicinal component having transdermal absorbability,
When affixed to the skin of the human body, the production method of the adhesive patch according to any one of claims 1 to 10 wherein the medicinal ingredient exhibits an efficacy to exert, it is characterized. The holding member is made of a porous material having a fine uneven surface capable of passing at least one of air, moisture and moisture,
In the effect composition softening adhesion laminating step, the cutting cooling non-deformation effect composition changes from a non-deformed state to a flexible state, and a part of the softened flexible effect composition is uneven on the fine uneven surface of the holding member. attached in a state of entering the interior of the flexible efficacy composition flexible state is processed in a state of fixation without peeling the holding member, patch according to any one of claims 1 to 12, characterized in that Manufacturing method. The fluid effect composition raw material contains at least water and a water-soluble polymer containing the water,
The first flow temperature is about 15 ° C. to about 90 ° C. at which the fluid effect composition raw material can flow;
The second cooling non-deformation temperature is a temperature range of about 5 ° C. or less at which the cooling non-deformation efficacy composition does not deform during cutting,
The patch according to any one of claims 1 to 13 , wherein the third non-flow softening temperature is about 5 ° C to about 50 ° C at which the softening composition has no fluidity. Method. Comprising at least a holding member and a soft and effective composition,
The flexible efficacy composition has a plurality of types of flexible efficacy compositions having different composition components from each other,
Each of the plurality of types of soft-effect compositions exhibits different effects from each other,
Each of the multiple types of flexible effect composition is composed of bonded to the surface of the holding member,
Each of the plurality of types of soft-effect compositions has at least water and a water-soluble polymer, has a flowable state at a first flow temperature, and is lower than the first flow temperature. The second cooling non-deformation temperature can be cut into a predetermined shape and has a non-deformation state that does not deform at the time of cutting. Each hydrogel soft-effect composition having no soft state,
The water-soluble polymer is at least one water-soluble polymer selected from the group consisting of at least polyacrylic acid, polyacrylic acid neutralized product, polyacrylic acid salts, and carboxyvinyl polymer,
A predetermined shape having a predetermined shape cut at the second cooling non-deformation temperature having a non-deformation state not deformed at the time of cutting and joined to a planar region of the surface of the holding member at the third non-flowing flexible temperature patch wherein each of the water-containing gel-like flexible efficacy composition, comprising consists are joined together is disposed in the planar region of the surface of the holding member, and having a. The patch according to claim 15 , wherein the plurality of kinds of soft-effect compositions exhibit a cooling effect at least when applied to the skin of a human body. The multiple types of soft-effect compositions contain at least a transdermally absorbable medicinal component,
When attached to the human skin, patch according to claim 15, wherein the medicinal ingredient exhibits an efficacy with, characterized in that. The plurality of types of soft-effect compositions include at least a first soft-action composition containing a transdermally absorbable medicinal ingredient, and an adhesive strength stronger than that of the first soft-action composition when applied to the human skin. patch according to claim 15 and a second flexible efficacy composition, characterized in that it exhibits the.

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