JP7329169B2 - Method for manufacturing patch containing packaged product, and patch containing packaged product - Google Patents

Description

Detailed description of the invention

TECHNICAL FIELD The present invention relates to an adhesive patch package that is packaged with an adhesive patch that, when applied to the human body, exhibits effects such as a cooling effect, a warming effect, a cooling effect, an analgesic effect, an anti-inflammatory effect, or other pharmacological effects. .

Various cooling patches comprising a water-containing gel composition mainly containing a water-containing water-soluble polymer as a cooling material to be applied to the human body, which is excellent in portability and stickability, instead of ice pillows and ice bags for heat generation in the human body. agents have been proposed.
In addition, a water-containing gel composition containing a water-containing water-soluble polymer contains medicinal ingredients such as an analgesic ingredient and an anti-inflammatory ingredient. Various medicinal patches have been proposed.
In addition, non-aqueous compositions containing no water, non-aqueous elastic compositions having elasticity such as synthetic rubber, natural rubber, etc., containing medicinal ingredients such as analgesic ingredients and anti-inflammatory ingredients, can be applied transdermally to the human body. Various medicinal patches have been proposed that act to produce effects corresponding to their medicinal ingredients.

For example, Japanese Patent Application Laid-Open No. 2000-107219 (Patent Document 1) discloses a water-retaining matrix made of a water-soluble polymer and containing 40% by weight or more of water, and a water-retaining matrix dispersed and retained in the water-retaining matrix. A cold-retaining/moisturizing gel comprising fibers having at least a hydrophilic surface, at least a portion of which is exposed on the surface of the water-retaining matrix, and retaining a large amount of water in the water-retaining matrix. In addition, the fibers allow moisture to easily move within the base material, and these fibers facilitate volatilization of moisture from the water-retaining base material to the outside, resulting in excellent cold-retaining ability. is disclosed.

Japanese Patent Application Laid-Open No. 2004-298474 (Patent Document 2) discloses that (A) polyacrylic acid and/or a salt thereof, (A) polyacrylic acid and/or a salt thereof, ( B) A patch coated with a water-containing gel containing a cross-linking agent, which exerts an excellent acupressure effect and provides high blood flow improvement and therapeutic effects in the affected area. In addition, it is disclosed that the hydrous gel layer having flexibility and elasticity acts as a cushion and does not cause sharp pains caused by projections, thereby providing a comfortable feeling of use for a long period of time.

Japanese Patent Application Laid-Open No. 2004-231577 (Patent Document 3) discloses that functional components such as aromatic oils and pharmacologically active substances are carried in a water-retaining gel containing at least a water-soluble polymer, water, and a functional component and then slowly released. When a pad material in which gel particles are dispersed and using a water-retaining gel is continuously applied to the human body, the substantial sensory effect and sensory effect of the pad material gradually decrease. It is disclosed that the effect of suppressing this and exhibiting a sufficient sensory effect over a long period of time.

Japanese Unexamined Patent Application Publication No. 2003-183156 (Patent Document 4) describes an external patch comprising a support provided with a base layer, wherein the base composition forming the base layer contains a non-aqueous base, indomethacin and the like. It is disclosed that the patch for external use contains a medicinal ingredient and polyethylene glycol, and exhibits the effect of suppressing skin disorders while maintaining good adhesiveness, feeling of use, etc. of the patch.

Retable No. 2001-47559 (Patent Document 5) discloses an external patch having a support and a drug-retaining layer coated on the support, wherein the drug-retaining layer comprises a water-soluble polymer. A compound of tetracaine, procaine, dibucaine, lidocaine, benzocaine, xylocaine, or a pharmaceutically acceptable salt thereof as an active ingredient in an adhesive gel base comprising a substance, a cross-linking agent, water, and a water retention agent as essential ingredients and a nonsteroidal anti-inflammatory analgesic consisting of ketoprofen, piroxicam, felbinac, bufexamac, suprofen, flurbiprofen, diclofenac, ibuprofen, or a pharmaceutically acceptable salt compound thereof. An external patch comprising a drug-containing base, the external patch being an analgesic for pain associated with inflammation selected from the group consisting of rheumatoid arthritis, osteoarthritis, and lumbago, It has been disclosed that it can improve the analgesic effect of pain associated with inflammation such as rheumatoid arthritis, osteoarthritis and lumbago.

Japanese Patent Application Laid-Open No. 2001-64161 (Patent Document 6) discloses a patch consisting of a backing part and an adhesive part, which has an adhesive part and contains indomethacin, ketoprofen, flurbiprofen, felbinac, diclofenac, or cromoglyc. It is a patch containing a poorly water-soluble drug such as an acid, which causes peeling and curling. It is disclosed that it exhibits excellent usability without remaining on the skin surface.

JP-A-2000-107219 JP 2004-298474 A JP 2004-231577 A JP 2003-183156 A Retable 2001-47559 Japanese Patent Application Laid-Open No. 2001-64161

In the above-described conventional patches and patch-containing packages in which the patches are accommodated in a packaging container, the surface of the sheet-shaped holding member is generally coated with a raw material for a hydrous gel composition, a raw material for a plaster composition, or the like. A functional composition raw material in a fluid state is laminated, a peeling protection member is further laminated on the surface of the functional composition raw material in a fluid state, and then the functional composition raw material in a fluid state out of the laminated laminate is laminated. A patch is produced by a method including a aging treatment step of aging to a soft state to the extent that it does not flow and processing it into a softening composition, and then further laminated on the surface of the holding member and aged to a soft state. A method of producing a patch containing package by storing the patch composed of a softening composition and a peeling protective member in a packaging container capable of suppressing moisture and air permeation and sealing the packaging container. , patch storage packages are manufactured.

An example of a conventional method for manufacturing a general adhesive patch containing package will be described below.
12 and 13 are schematic process diagrams illustrating an example of the manufacturing process of a conventional method for manufacturing a patch containing package.
In FIG. 13, an example of a conventional method for manufacturing a patch containing packaged product is manufactured by the following steps.
(a) Step: Fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material 22a having a fluid state capable of flowing at the first flow temperature.
(b) Step: On a predetermined position area of the surface of the holding member 21, the fluid efficacy composition raw material 22a and the peeling protective member 23 are laminated with the peeling protective member 23 positioned on the surface side. Peeling protection member lamination step for preparing a fluid efficacy composition raw material/peeling protection member laminate.
(c) Step: The holding member/fluid effect composition raw material/peeling protective member laminate is subjected to a softening process in which the fluid effect composition raw material 22a is softened from a fluid state to a non-fluid soft state in an atmosphere at the third softening aging temperature. A holding member/softening effect composition/peeling protective member laminate in which the benefit composition 22 is aged and changed, and the softening benefit composition 22 is adhered and bonded to the retainer, and the softening benefit composition 22 is adhered and bonded to the retainer member. A patch 2 containing a patch comprising a holding member, a softening composition, and a peeling protection member having a configuration in which the flowable composition raw material 22a is aged into a softening composition 22 by this aging step. is obtained.
(d) Step: Sealing the opening of the packaging container 3 with the patch 2 positioned in the packaging container 3 to form the packaging container sealing portion 3a. As a result, a patch storage package containing the patch 2 is obtained.

In FIG. 12, an example of a conventional manufacturing method for a patch containing packaged product is manufactured by the following steps.
(a) Step: Fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material 22a having a fluid state capable of flowing at the first flow temperature.
(b-a) Step: Laminate and hold the fluid efficacy composition raw material 22a and the peel protection member 23 in a predetermined position area on the surface of the holding member 21 with the peel protection member 23 positioned on the surface side. A release protection member lamination step for preparing a member/flow effect composition raw material/peeling protection member laminate, in which the flow effect composition raw material 22a is laminated so as to be positioned inside the peripheral portion of the surface of the holding member 21. .
In place of the (b-a) step, the (b-b) step: the fluid efficacy composition raw material 22a and the peeling protection member 23 are placed in a predetermined position area on the surface of the holding member 21, and the peeling protection member 23 is on the surface side. A peeling protective member lamination step for preparing a holding member/fluid efficacy composition raw material/peeling protective member laminate by laminating in a state where the are stacked so that they are positioned at the same position as
(b-c) step: After the step (b-a) or (b-b), as the time elapses, the fluid efficacy composition raw material 22a becomes more fluid, so that the fluid efficacy composition raw material 22a As the thickness H decreases to a thickness H2, the flow benefit composition raw material 22a protrudes from the end face of the holding member 21 by a protruding length L2.
Alternatively, step (b-d): after the step (b-a) or (b-b), the fluid efficacy composition raw material 22a becomes more fluid with the passage of time. As the thickness H of 22a decreases to thickness H2, the fluid efficacy composition raw material 22a protrudes from the end surface of the holding member 21 and flows in the direction of the end surface of the holding member, protruding and flowing out with a length of L2. Become.

(c-a) step: In the state of the (b-c) step, the holding member/flowing effect composition raw material/peeling protective member laminate is heated to the same temperature as the first flow temperature or the third soft aging temperature. In the atmosphere, the fluid composition raw material 22a is aged from a fluid state to a soft composition 22 having no fluidity, and the softening composition 22 is adhered and joined to the holding member to form the softening composition 22. A holding member having a configuration in which the holding member/softening effect composition/peeling protective member laminate is prepared by adhering and bonding to the holding member, whereby the flowing benefit composition raw material 22a is aged into the softening benefit composition 22. - A patch 2 containing a patch having a softening composition and a peel protection member is obtained. Here, the protruding fluid benefit composition raw material 22a is also matured from the fluid state to the flexible benefit composition 22 having adhesiveness without fluidity.
Alternatively, the step (c-b): in the state of the step (b-d), the holding member/flow effect composition raw material/peeling protective member laminate is heated to the same temperature as the first flow temperature, or the third soft aging In a temperature atmosphere, the fluidizing composition raw material 22a is aged from the fluid state to the softening composition 22 having no fluidity, and the softening composition 22 is adhered and joined to the holding member to form the softening composition. A maturing step for preparing a holding member/flexible benefit composition/peeling protective member laminate in which the material 22 is adhered and bonded to the holding member, whereby the fluid benefit composition raw material 22a is aged into the softening benefit composition 22. A patch 2 containing a holding member, a softening composition, and a peeling protective member is obtained. Here, the fluidizing effect composition raw material 22a, which protrudes and adheres to the end surface of the holding member, is also matured from the fluid state to the flexible effect composition 22 having adhesiveness without fluidity.

(d-b) Step: The opening of the packaging container 3 is sealed while the patch 2 is positioned in the packaging container 3, whereby a patch containing package containing the patch 2 is obtained. be done. Here, the softening effect composition 22 in the softening state having stickiness without fluidity protruding out maintains the aged state.
Alternatively, (d-b) step: The opening of the packaging container 3 is sealed while the patch 2 is positioned in the packaging container 3, thereby producing a patch containing package containing the patch 2. is obtained. Here, the softening effect composition 22 in the softening state having adhesiveness without fluidity, which protrudes and adheres to the end surface side of the holding member, maintains the matured state.
In this way, a conventional patch containing package is manufactured.

Another example of the conventional manufacturing method of a patch containing package product is manufactured by the following steps.
The holding member/fluid efficacy composition raw material/peeling protective member laminate prepared by the steps (a) and (b-a) in FIG. seal the opening of the
Then, the holding member/fluid effect composition raw material/fluid effect composition raw material 22a of the peel protection member laminate housed in the packaging container is aged into the softening effect composition 22 having flexibility without fluidity. As a result, the adhesive patch 2 containing the adhesive patch provided with the holding member, the softening composition, and the peeling protective member is obtained.
Also in this conventional manufacturing method, as shown in FIG. decreases to a thickness H2, the flowable efficacy composition raw material 22a protrudes from the end surface of the holding member 21 with a length of L2, and flows and adheres to the end surface of the holding member while protruding. As shown in (c-a), the fluid benefit composition raw material 22a is aged from the fluid state to the flexible benefit composition 22 in a non-fluid and viscous soft state.

In the above-mentioned conventional patch containing package product containing a patch in a packaging container, a step of manufacturing a patch composed of a holding member, a softening composition, and a peel-protecting member, and applying the patch. It is manufactured by two processes, one for storing the agent in a packaging container and the other for sealing, and there is a demand for further efficiency improvement of the manufacturing process for manufacturing patch-containing packages.

In addition, if the patch is manufactured for a long period of time before it is placed in a packaging container, the ingredients contained in the softening effect composition may evaporate or evaporate during the manufacturing process, or may be contained due to chemical reactions with air. Content composition changes due to deterioration of components, etc., and this tends to destabilize the quality of the patch.

In addition, due to the inclusion of a manufacturing method in which the active composition raw material in a fluid state is laminated on the surface of the holding member in the conventional adhesive patch storage package, the thickness of the flexible efficacy composition that has matured into a flexible state, There is a tendency for the dimensional accuracy and positional accuracy of the planar shape and stacking position to vary, which is the cause of defective products.

In addition, in conventional patch containing packages, a patch is manufactured in which the flexible efficacy composition configured between the holding member and the peeling protective member protrudes from the edge between the holding member and the peeling protective member. defects tend to occur. When the adhesive patch that constitutes the protruding functional softening composition is placed in a packaging container, the protruding functional softening composition adheres to the inner surface of the packaging container, making it easy to remove the patch from the packaging container. There is a tendency for the inconvenience of not having one. Furthermore, when the patch is applied to the skin of the human body, the protruding composition for softening exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, and the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, there is a tendency that a portion of the back side of the holding member is sticky, giving an unpleasant feeling.

In addition, the holding member/fluid efficacy composition raw material/peeling protection member laminate composed of the holding member, the fluid efficacy composition raw material, and the peel protection member is housed in a packaging container and sealed, and the storage and sealing state is achieved. Even in the case of a patch storage package having a step of maturing a fluid efficacy composition raw material into a non-flowing flexible efficacy composition in the Defects tend to occur in which a patch is produced that protrudes from the edge between the member and the peel protection member. Since the patch that constitutes the protruding composition for softening is stored in the packaging container, the composition for softening that protrudes adheres to the inner surface of the packaging container, wrapping the patch. Inconvenience arises in that it cannot be easily removed from the container. Furthermore, when the patch is applied to the skin of the human body, the protruding composition for softening exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, and the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, there is a tendency that a portion of the back side of the holding member is sticky, giving an unpleasant feeling.

The present invention solves the above-mentioned problems, and provides a patch storage package that can be manufactured in a fewer number of steps than before, containing a patch in which a holding member, a flexible active substance, and a peeling protection member are laminated. A manufacturing method and a patch storage package are provided.
In addition, by solving the above-mentioned problems, a method for manufacturing and attaching a patch storage package that can laminate a flexible efficacy composition on the surface of a holding member with high precision in terms of thickness, area, shape, lamination position, etc. To provide a drug storage package.
Further, by solving the above-mentioned problems, the present invention provides a method for manufacturing an adhesive patch storage package and an adhesive patch storage package capable of suppressing the phenomenon of the soft and effective composition being squeezed out between the holding member and the peeling protective member. .

The method for producing a patch containing package of the present invention includes (a) a sheet-shaped holding member, a flexible composition adhered and bonded to the holding member and laminated, and the flexible composition. A patch having a sheet-like peeling protective member laminated on its surface so that it can be peeled off during use, and (b) a packaging container containing the patch, The softening effect having adhesiveness and having adhesiveness, wherein the adhesive patch is taken out from the packaging container at the time of use, the peel protection member is peeled off from the taken-out patch, and the adhesive is laminated and joined to the holding member. A method for manufacturing an adhesive patch storage package for use by attaching a composition to the skin of a human body, wherein the packaging container has flexibility to the extent that it can be deformed along the shape of the adhesive patch, (A) a step of preparing a raw material for the beneficial composition; (B) laminating the raw material for the beneficial composition and the peelable protective member on a predetermined position area on the surface of the holding member, with the peelable protective member positioned on the surface side; (C) a state in which the holding member/effective composition raw material/peeling member laminate is placed in a packaging container; Then, the opening of the packaging container is sealed so that the packaging container deforms along the shape of the holding member/effective composition raw material/peeling member laminate and is in close contact with the laminate. and (D) aging the efficacy composition raw materials constituting the laminate storage package into a flexible efficacy composition in a flexible state without fluidity, and the flexible efficacy composition. A maturing step of adhering and bonding a substance to the holding member to prepare a holding member/softening benefit composition/release protective member laminate in which the softening benefit composition is adhered and joined to the holding member, whereby the benefit composition raw material is A patch comprising a holding member, a softening composition, and a peeling protection member having a configuration matured into a flexible composition having adhesiveness without fluidity and a flexible state is formed, and the patch is used for packaging. The present invention is characterized by having a configuration that allows obtaining a patch containing package product housed in a container.

A patch containing package of the present invention comprises a patch and a packaging container containing the patch, wherein the patch is stored in a sheet-like holding member and a predetermined position area on the surface of the holding member. The softening composition comprises a flexible softening composition that is adhered and bonded and laminated, and a sheet-like peeling protection member that is laminated on the surface of the softening composition so that it can be peeled off during use. has adhesiveness, and at the time of use, the patch is taken out from the packaging container, the peel protection member is peeled off from the taken out patch, and the flexible adhesive is laminated and joined to the holding member. A patch storage package for use by applying an efficacy composition to the skin of a human body, wherein the packaging container has flexibility to the extent that it can be deformed along the shape of the patch, and the patch contains the patch. is positioned in the packaging container and the packaging container is in close contact along the shape of the patch, and the patch is housed in the packaging container and sealed. In a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch, the softening composition has stickiness and a flexible state. It is characterized by comprising a composition having an aged form which is aged in the form of an efficacy composition.

The present invention provides the following effects.
[Method Effect A: Adhesive storage of patches]:
According to the method for manufacturing a patch-containing package according to the present invention, a step of manufacturing a patch in which a holding member, a matured flexible active substance, and a peel-off protective member are laminated, and a step of storing the patch in a storage container. A patch that can form a patch having a softening effect composition that has been matured while being housed in a packaging container without going through both processes, and that contains the patch that has the matured softening effect composition As a result, it is possible to obtain the effect of being able to manufacture a package containing an adhesive patch that greatly simplifies the manufacturing process, improves mass productivity, and significantly reduces costs. be done.
In addition, since the softening effect composition is aged in the packaging container, the time from the production of the patch to the packaging container can be shortened.
In addition, changes in composition and chemical deterioration due to deterioration and deterioration of ingredients due to evaporation of ingredients contained in the softening composition during the manufacturing process or chemical reactions with air are suppressed, and stable quality is achieved. A patch having
Furthermore, in a state in which the packaging container is deformed along the shape of the holding member/effective composition raw material/releasing member laminate and closely attached, the flexible effective composition is matured and changed into a soft state, Since the shape of the active composition raw material is maintained during aging, the active composition raw material sandwiched between the holding member and the peeling protective member is prevented from protruding from between the holding member and the peeling protective member. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated. Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use.

[Constructive effect A: patch storage package]:
In the patch containing package of the present invention, the patch is placed in a packaging container and the packaging container is in close contact along the shape of the patch. Due to the composition having a composition having a matured form that is aged in the form of the efficacy composition, the ingredients contained in the softening efficacy composition are altered or deteriorated due to evaporation or chemical reaction with the air. change in composition and chemical deterioration are suppressed, and an effect of obtaining a patch containing package having stable quality can be obtained.
Furthermore, since the shape of the active composition raw material is maintained during aging, the active composition raw material sandwiched between the holding member and the peeling protective member is prevented from separating from the holding member and the peeling protective member. Extrusion is prevented. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated.
Furthermore, when the patch is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side of the holding member is eliminated. , a patch storage package that can be used comfortably is obtained.

FIG. 2 is a process explanatory diagram and a schematic process diagram illustrating the manufacturing process of the manufacturing method of the adhesive patch containing package according to one embodiment of the present invention. FIG. 2 is a process explanatory diagram and a schematic process diagram illustrating the manufacturing process of the manufacturing method of the adhesive patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. FIG. 2 is a schematic plan view showing the arrangement of a plurality of types of softening compositions of the patch contained in the patch containing package of one example of the present invention. FIG. 2 is a schematic plan view showing the shape of the softening composition contained in the patch contained in the patch containing package of one example of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. FIG. 2 is a schematic process diagram illustrating manufacturing steps of an example of a method for manufacturing a conventional patch containing package. FIG. 2 is a schematic process diagram illustrating manufacturing steps of an example of a method for manufacturing a conventional patch containing package.

<Regarding the manufacturing method of the patch storage package>
Embodiments for carrying out the invention will be described below with respect to the method for manufacturing the patch containing packaged product and the patch containing packaged product of the present invention. In the drawings, the dimensions such as the shape, length, size, thickness, etc. of each component are not shown accurately, but are shown schematically.

FIG. 1 is a process explanatory drawing and a schematic process diagram for explaining the manufacturing process of the method for manufacturing a patch containing package according to one embodiment of the present invention.
In the schematic process diagrams illustrated in (A), (B), (C), and (D) of FIG. , a softening composition 22 adhered and laminated on the holding member 21 and having flexibility, and a sheet-like peeling protective member 23 laminated on the surface of the softening composition 22 so as to be peelable during use. and (b) a packaging container 3 containing the patch 1. The softening composition 22 has adhesive properties, and when used, the patch 2 is taken out from the packaging container 3, the peeling protective member 23 is peeled off from the taken out patch 2, and the softening composition 22 laminated and joined to the holding member 21 is applied to the human skin. A method for manufacturing an adhesive patch containing package 1, which is used in an application, comprises the following configuration and steps.
The packaging container 3 has flexibility to the extent that it can be deformed along the shape of the patch 2 .
(A) Step of preparing the efficacy composition raw material 22a.
(B) The effective composition raw material 22a and the peeling protective member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peeling protective member 23 positioned on the surface side to form a holding member/effective composition. Lamination member lamination step for preparing raw material/peeling protective member laminate.
(C) The holding member/effective composition raw material/releasing member laminate is placed in a packaging container 3, and the packaging container has the shape of the holding member/effective composition raw material/releasing member laminate. a laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container 3 so as to be deformed and brought into close contact along the .
(D) The efficacy composition raw material 22a that constitutes the laminate storage package is matured into a softening efficacy composition 22 in a flexible state without fluidity, and the softening efficacy composition 22 is adhered and joined to the holding member 21. Then, an aging step of preparing a holding member/softening composition/peeling protective member laminate in which the softening composition 22 is adhered and bonded to the holding member 21, whereby the efficacy composition raw material 22a becomes sticky without fluidity. A patch 2 having a holding member, a softening composition, and a peeling protection member having a configuration matured into a softening composition 22 having flexibility and flexibility is formed, and the patch 2 is placed in a packaging container 3. The stored patch containing package 1 is obtained.

This configuration provides the following effects.
The present invention provides the following effects.
[Method Effect A: Adhesive storage of patches]:
According to the method for manufacturing a patch-containing package according to the present invention, a step of manufacturing a patch in which a holding member, a matured flexible active substance, and a peel-off protective member are laminated, and a step of storing the patch in a storage container. A patch that can form a patch having a softening effect composition that has been matured while being housed in a packaging container without going through both processes, and that contains the patch that has the matured softening effect composition As a result, it is possible to obtain the effect of being able to manufacture a package containing an adhesive patch that greatly simplifies the manufacturing process, improves mass productivity, and significantly reduces costs. be done.
Furthermore, since the softening effect composition is aged in the packaging container, the time from the production of the patch to the packaging container can be shortened.
Furthermore, as a result, the content composition change and chemical deterioration due to the deterioration and deterioration of the ingredients due to the evaporation and emission of the ingredients contained in the softening composition during the manufacturing process or the chemical reaction with the air are suppressed, and the composition is stabilized. A plaster having a high quality is obtained.
Furthermore, since the packaging container is deformed along the shape of the holding member/beneficial composition raw material/releasing member laminate and is in close contact with the flexible composition, the composition is matured into a flexible composition in a soft state. Since the shape of the active composition raw material inside is maintained, the active composition raw material sandwiched between the holding member and the peeling protective member is prevented from protruding from between the holding member and the peeling protective member. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated.
Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use.

<Method for Constituting Fluid Effective Composition Raw Materials>
In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method including the following steps can also be carried out.
The beneficial composition raw material 22a is a fluid beneficial composition raw material 22a having a flowable state, and the efficacy composition raw material 22a is a fluid beneficial composition raw material 22a having a flowable fluid state, and has the following configuration: Prepare.
(A) A fluid efficacy composition raw material preparation step for preparing a fluid efficacy composition raw material 22a having a flowable fluid state.
(B) The fluid efficacy composition raw material 22a and the peel protection member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peel protection member 23 positioned on the surface side. Lamination member lamination step for preparing the composition raw material/peeling protective member laminate, where the flowing effect composition raw material 22a has a predetermined shape and fluidity.
(C) The holding member/effective composition raw material/releasing member laminate is placed in a packaging container 3, and the packaging container has the shape of the holding member/effective composition raw material/releasing member laminate. A laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container 3 so as to deform and adhere along the has a predetermined shape and maintains fluidity.
(D) The fluidizing composition raw material 22a constituting the laminate containing package is aged into the softening composition 22 in a non-fluid state, and the softening composition 22 is adhered and joined to the holding member 21. , Aging step of preparing a holding member/softening composition/peeling protective member laminate in which the softening composition 22 is adhered and bonded to the holding member 21, whereby the fluid composition raw material 22a becomes sticky and non-fluid. A patch 2 is formed that includes a holding member, a softening composition, and a peeling protection member having a structure matured into a softening composition 22 having a flexible state, and the patch 2 is accommodated in the packaging container 3. A patch containing package 1 is obtained.

This configuration provides the following effects.
[Method Effect A: Fluid Effective Composition Raw Material]:
In addition to obtaining the aforementioned [Method Effect A: Adhesive storage of the adhesive patch], the packaging container is deformed along the shape of the holding member, the active composition raw material, and the peeling member laminate, and in a state of being in close contact, a flowable flow is obtained. In addition, the shape of the fluid performance composition raw material during aging is maintained because the fluid performance composition raw material having a state is aged and changed into a flexible performance composition having a non-flowable soft state having a retention shape. As a result, it is possible to prevent the flow benefit composition raw material sandwiched between the holding member and the peeling protective member from squeezing out from between the holding member and the peeling protective member. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated. Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use.

Although not shown, the holding member/effective composition raw material/peeling protective member laminate obtained in the step (B) or the laminate containing package obtained in the step (C) are placed at a predetermined interval. It is also possible to carry out a configuration comprising a step of passing between two rolls to adjust the thickness of the effective composition raw material more accurately and further improving the adhesion between the holding member and the effective composition raw material.

The holding member 21 is not particularly limited, but for example, a material composed of a porous material having a fine uneven surface is desirably possible, and a part of the softening composition 22 is on the fine uneven surface of the holding member 21. The softening composition 22 adheres to the inside of the unevenness in a state of getting into the concave and convex portions, thereby obtaining a function and effect that the softening composition 22 in a soft state is joined to the holding member 21 without being peeled off.
The holding member 21 is not particularly limited as long as the softening composition 22 permeates the holding member 21 and the softening composition 22 is sufficiently retained. A fiber aggregate such as non-woven fabric or woven fabric using synthetic fibers and natural fibers, and a fiber aggregate such as paper can be used. In addition, as the holding member 21, a structure having stretchability is particularly desirable. The patch can be freely applied to the human body, and even after being applied, the patch expands and contracts freely according to the movement of the human body, and the holding member 21 and the softening composition 22 do not separate at the boundary. 2 can be stably used without peeling off from the human body.

The peel protection member 23 is laminated on the surface of the softening composition 22 having stickiness to protect the surface of the softening composition, and is peeled off from the surface of the softening composition 22 when used.
The peel protection member 23 is not particularly limited, but it is suitable for protecting the surface of the softening composition 22 having stickiness during storage, such as polypropylene film, polyethylene film, polyester film, and other plastic films. , and can be easily peeled off from the surface of the softening composition 22 during use.

As the packaging container having flexibility to the extent that it can be deformed along the shape of the patch, a container having a configuration capable of suppressing or preventing intrusion of atmospheric air, a container having a desired function, and the like can be used. The material that can be used as the packaging container is not particularly limited, but for example, single-layer films such as plastic films and metal foils, or laminated laminate films can be used. Single-layer films include polyethylene terephthalate (PET) films, polyamide (nylon) films, polyvinyl alcohol films, polypropylene films, polyethylene films, ethylene-vinyl acetate copolymer films, polyacrylonitrile films, and others. A deformable plastic film or the like can be used. As the laminated laminate film, the deformable plastic film, metal foil sheet (e.g., aluminum foil sheet), paper sheet, kraft paper, woven fabric sheet, nonwoven fabric sheet, metal (e.g., aluminum) vapor-deposited plastic A laminate film obtained by laminating two or more kinds of sheet-like films such as a sheet made of a material can be used.
In addition, as a container sheet for packaging having desired functions, the function of suppressing air permeation, the function of having bending toughness, the function of wrinkle prevention, the function of being resistant to tearing, the function of having desired tearability, the function of printing characters, etc. Any sheet material having the desired functionality or other desired functionality can be used.
A configuration using a material that can significantly suppress the permeability of gas, air, humidity, etc. is also desirable and usable. For example, a laminate film composed of a metal foil such as aluminum foil or a plastic film having a metal vapor deposition film is particularly preferred. Desirably, this suppresses the transpiration of components such as water contained in the patch during storage of the patch storage package, and provides a flexible and effective composition due to the intrusion of air, putrefactive bacteria, etc. from the outside. The effect of suppressing deterioration and putrefaction of things can be obtained.
The thickness of the packaging container having flexibility to the extent that it can be deformed along the shape of the patch is not particularly limited, and varies depending on the material. Polyamide/high-density polyethylene multilayer laminate film, polyethylene terephthalate/aluminum foil/polyethylene terephthalate/polyethylene multilayer laminate film, kraft paper/aluminum foil/polyethylene multilayer laminate film, polyamide/aluminum-deposited polyethylene terephthalate/polyethylene multilayer laminate film Multi-layer laminated film, kraft paper/polyethylene terephthalate/aluminum foil/polypropylene multi-layer laminated film, aluminum-deposited polyethylene terephthalate/aluminum foil/polyethylene multi-layer laminated film to the extent that it can be deformed along the shape of the patch. The total thickness of the laminate film having flexibility of about 0.01 to about 0.3 mm is desirably practicable. The thickness of each plastic film sheet constituting the laminate film is preferably about 10 to about 100 μm, and the thickness of the aluminum foil is preferably about 5 to about 20 μm.
In addition, as a packaging container, it is also possible to preferably implement a configuration in which the opening of a packaging container made of a laminate film having polyethylene or polypropylene as an inner layer is heated and pressed to seal the opening by heat sealing. The joint sealing of the opening is easily carried out.

<Regarding the method for forming the cooled non-deformable cooling benefit composition raw material>
In the method of manufacturing a patch containing package of the present invention, the softening composition 22 has a fluid state in which it can flow at the first fluidizing temperature, and at the second cooling non-deformation temperature which is lower than the first fluidizing temperature. A softening effect composition 22 having a non-deformed state to the extent that it is not deformed and having a soft state in which it is changed to a non-fluid form without fluidity at the third softening aging temperature that is the second cooling non-deforming temperature is raised is also implemented. It is possible.
That is, in the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
FIG. 2 is a process explanatory diagram and a schematic process diagram illustrating another manufacturing process of the method for manufacturing a patch containing package according to one embodiment of the present invention.
In FIG. 2, the emollient composition 22 has a flowable state at a first flow temperature and a non-deformed state at a second cooling non-deformation temperature that is lower than the first flow temperature. Then, at the third soft aging temperature, which is the second cooling non-deformation temperature, it has a soft state in which it is changed into a non-flowing form without fluidity.
The beneficial composition raw material 22a is the cooled non-deformed beneficial composition raw material 22a that has been cooled to the second cooled non-deformed temperature.
And it is characterized by having the following configurations.
(A) A fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material 22a having a flowable state at a first flow temperature, and a second cooling to bring the fluid efficacy composition raw material 22a into a non-deformed state. a cooled predetermined shape forming step of cooling to a non-deformed temperature to prepare a cooled non-deformed effective composition raw material 22b in a non-deformed state having a predetermined shape;
(B) The cooling non-deforming effect composition raw material 22b and the peeling protection member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peeling protection member 23 positioned on the surface side. Laminate member lamination step for preparing a benefit composition raw material/peel protection member laminate, wherein said cooled non-deformed benefit composition raw material 22b remains in a non-deformed state.
(C) The holding member/effective composition raw material/release member laminate is placed in a packaging container, and the packaging container is formed into the shape of the holding member/effective composition raw material/release member laminate. a laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container 3 so as to deform along and adhere to the packaging container 3, wherein the cooled non-deformed effective composition raw material 22b remains undeformed.
(D) The temperature of the laminate containing package is raised to a third soft aging temperature to ripen the cooled non-deformed beneficial composition material 22b into the flexible beneficial composition 22 in a flexible state without fluidity and the softening effect. A maturing step of adhering and bonding the composition 22 to the retaining member 21 to prepare a retaining member/softening composition/peeling protective member laminate in which the softening composition 22 is adhered and bonded to the retaining member 21, thereby Forming a patch 2 equipped with a holding member, a flexible composition, and a peeling protection member having a configuration in which the active composition raw materials are matured into a flexible composition 22 having stickiness and a flexible state without fluidity, A patch-containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.
For example, as an example, in FIG. 2, the ingredient of the benefit composition is cooled to about -3° C. in step (A), maintained in the cooled state in steps (B) and (C), and (D) In the step, in a room temperature atmosphere of about 10° C. to about 30° C., or heated to about 30° C. to about 60° C., the ingredients of the effective composition turn into a hydrous gel during the heating process and/or at the elevated room temperature. It is possible to implement a method that results in a matured composition in the form of softening benefit composition.

This configuration provides the following effects.
[Method effect C: Cooling non-deforming effect composition raw material]:
The aforementioned [Method Effect A: Adhesive storage of the patch] is obtained, and the fluidity is improved in a state in which the packaging container is deformed and adheres to the shape of the holding member/effective composition raw material/peeling member laminate. In order to change the cooling non-deformed benefit composition raw material without flowability into a flexible benefit composition in a non-flowable state by aging, and to maintain the shape of the benefit composition raw material during aging, desired In addition, it is possible to prevent the raw material of the fluid benefit composition sandwiched between the holding member and the peeling protective member from squeezing out from between the holding member and the peeling protective member. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container is eliminated. Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use. In addition, it is possible to stably and accurately mass-produce patches with the desired performance without changing the ratio of the ingredients due to the evaporation of the ingredients during aging, and as a result, the yield of non-defective products can be significantly improved. Therefore, it is possible to stably mass-produce patches containing packages having desired quality, and to significantly reduce costs.

"Aging" means "aging from the raw material of the efficacy composition to the softening efficacy composition", and in terms of chemical structure, the ingredients such as the water-soluble polymer are crosslinked from the one-dimensional chemical structure to form a mesh structure. Or the phenomenon of changing to a three-dimensional chemical structure, or the phenomenon of changing from a fluid state to a non-fluid, flexible state without a fluid state, or a fluid state from a cooled solid state to a heated fluid state. It means the phenomenon of changing from a non-flowing state to a flexible state without
For example, "aging" means that the laminate containing package obtained in the (C) step is heated to a temperature of about 10 ° C. or higher in the (D) step, and crosslinked in the process of raising the temperature or in a room temperature atmosphere. It refers to a phenomenon in which the water-soluble polymer is cross-linked and the ingredient of the benefit composition matures into a non-fluid, non-fluid, flexible state. For example, the effective composition raw material is heated from a cooled state to about room temperature of about 10° C. to 30° C., or to about 30° C. to 60° C., and in the process of heating or at the elevated temperature, the crosslinkable water-soluble highly It means a structure in which the molecules are cross-linked and the ingredients of the benefit composition are matured and changed into a non-fluid, soft state without a fluid state.
The "flowable state" of the softening benefit composition at the first flow temperature is obtained by placing the softening benefit composition in a polystyrene cup-shaped container of about 200 ml and tilting the cup at an angle of about 45 degrees. It means a fluid state in which the softening benefit composition has the property of flowing and deforming from the container within about 5 seconds when the container is tilted to the right.
The "non-deformed state" of the softening composition at the second cooling non-deformation temperature refers to a state in which the shape of the softening composition is not deformed in a stationary state without applying external pressure, and/or When the cooled non-deformable benefit composition is cut using a flat plate cutting device equipped with a double-edged press cutting die having a blade edge angle of about 30 degrees and a height of about 5 mm, the cooled non-deformable benefit composition deforms. It means a non-deformed state in which it is cut without being cut and separated into a desired shape.
The "soft state without fluidity" at the third soft aging temperature is a non-woven fabric that has flexibility, bending flexibility and air humidity permeability containing polyethylene terephthalate fibers with a thickness of about 1 mm and a square of 300 mm. When the softening composition was applied to a thickness of about 3 mm on the surface of the member and maintained at an angle of about 45 degrees for 60 seconds, the softening composition deformed without flowing. It means a state in which a non-deformed state in which the original shape is maintained is maintained.

<Regarding the method for constructing the raw material of the cut cooling non-deforming benefit composition that has been cooled and cut>
In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
FIG. 3 is a process explanatory diagram and a schematic process diagram illustrating another manufacturing process of the method for manufacturing a patch containing package according to an embodiment of the present invention.
In FIG. 3, the emollient composition 22 has a flowable flow state at a first flow temperature and is cuttable and deformable before and after cutting at a second cooling non-deforming temperature that is lower than the first flow temperature. It has a non-deformed state to the extent that it does not deform, and has a soft state without fluidity at the third soft aging temperature that is raised from the second non-deformed cooling temperature. A cut cooled undeformed benefit composition raw material 22c having a predetermined shape that has been cooled to a temperature and cut at the second cooled undeformed temperature, comprising the following configuration.
(A) A fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material 22a having a flowable state at a first flow temperature, and a second cooling to bring the fluid efficacy composition raw material 22a into a non-deformed state. Cooling to an undeformed temperature to form a cooled undeformed benefit composition material 22b in an undeformed state, and then cutting the cooled undeformed benefit composition material 22b into a predetermined shape to cut and cool undeformed benefit composition material 22c. Predetermined shape forming step to prepare.
(B) The cutting/cooling non-deformable effective composition raw material 22c and the peeling protection member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peeling protection member 23 positioned on the surface side. • A lamination member lamination step to prepare a benefit composition raw material/peel protection member laminate, wherein said cut and cooled non-deformed benefit composition raw material 22c remains in a non-deformed state.
(C) The holding member/effective composition raw material/releasing member laminate is placed in a packaging container, and the packaging container 3 is in the shape of the holding member/effective composition raw material/releasing member laminate. A laminate packaging step of preparing a laminate containing package by sealing the opening of the packaging container 3 so that it is deformed and adhered along the The material source 22c remains undeformed.
(D) The temperature of the laminate containing package is raised to a third soft ripening temperature to ripen the cut and cooled non-deformed beneficial composition raw material 22c into the flexible beneficial composition 22 in a flexible state without fluidity, and the soft effect composition 22 is aged. A maturing step of adhering and bonding the benefit composition 22 to the retaining member to prepare a retaining member/softening benefit composition/peeling protective member laminate in which the softening benefit composition 22 is adhered and bonded to the retaining member 21, thereby Forming a patch 2 equipped with a holding member, a flexible composition, and a peeling protection member having a configuration in which the active composition raw materials are matured into a non-fluid flexible composition 22 having stickiness and a flexible state, A patch containing package 1 in which the patch 2 is contained in the packaging container 3 is obtained.
For example, as an example, in FIG. 3, the ingredient of the benefit composition is cooled to about −3° C. and cut in step (A), and the cooled state is maintained in steps (B) and (C), In step (D), in a room temperature atmosphere of about 10° C. to about 30° C., or heated to about 30° C. to about 60° C., during the heating process and/or at the elevated temperature, the ingredients of the efficacy composition is matured into a water-containing gel-like softening composition.

This configuration provides the following effects.
[Method effect D: cutting cooling non-deforming effect composition raw material]:
The aforementioned [Method Effect A: Adhesive storage of the patch] and [Method Effect C: Cooling non-deforming effect composition raw material] are obtained, and the cooling non-deforming effect composition raw material is cut into a predetermined shape and cut and cooled non-deformable. It can be accurately cut into a desired planar shape and thickness shape in the predetermined shape forming process for preparing the active composition raw material, and since it is stored in a packaging container in close contact, the desired shape can be maintained during the aging process. Therefore, it is possible to easily manufacture a patch containing package having a desired shape without changing the shape. In addition, when cutting a softening composition having adhesiveness after aging, it is generally difficult to cut easily due to stickiness, and residue of the softening composition adheres to the cutting edge of the blade. On the other hand, the method of the present invention solves the above problems, enables cutting into a desired shape, and leaves residue of the softening composition. It is possible to cut easily without inconvenience such as reducing the amount of clothing, and as a result, the softening composition laminated on the holding member can be formed with high accuracy in desired thickness, area, shape, weight, lamination position, etc. It becomes possible. In addition, since it is formed by transforming into a softening effect composition that has been aged in a packaging container, mass production of patch containing packages with stable quality without fluctuations in the ratio of the composition components contained. Formable. The yield of non-defective products can be remarkably improved, patches containing packages having desired quality can be stably mass-produced, and costs can be reduced.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
FIG. 4 is a process explanatory drawing and a schematic process diagram explaining another manufacturing process of the manufacturing method of the adhesive patch containing package according to one embodiment of the present invention.
This configuration includes the following configuration in the above-described step (B).
(B) Each of the cut cooling non-deforming effective composition raw materials 22c is positioned in a position area forming a blank portion at a predetermined interval on the surface of the holding member 21, and the peel protection member 23 is positioned on the surface side. Peel protection member 23 is laminated to cover each of the cut and cooled non-deformable effect composition raw materials 22c in the state of being positioned at the position of the blank portion, and then each of the cut and cooled non-deformable effect composition raw materials 22c is sandwiched between them at the position of the margin. A laminated member laminating step of cutting the peelable protective member 2 and the holding member 21 in the state of being cut to prepare a plurality of holding members/effective composition raw materials/peeling protective member laminates in this way, wherein the cutting The cooled undeformed benefit composition ingredient 22c remains undeformed. Other steps are the same as those described with reference to FIG.
With this configuration, the same effect as the aforementioned [Method effect D: Raw material of cutting-cooling non-deformation effect composition] can be obtained.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
FIG. 5 is a process explanatory view and a schematic process diagram illustrating another manufacturing process of the method for manufacturing a patch containing package according to one embodiment of the present invention.
This configuration has the following configurations in the above-described steps (A) and (B).
(AB) A flow benefit composition raw material preparation step of preparing a flow benefit composition raw material having a flowable state at a first flow temperature; cooling to a temperature to form a cooled non-deformed benefit composition material in an undeformed state; A lamination member lamination step of preparing a holding member/effective composition raw material/peeling protective member laminate by laminating in a state of being positioned on the surface side, and then forming the holding member/effective composition raw material/peeling protective member laminate into a predetermined shape. A plurality of holding member/effective composition raw material/peeling protective member laminates are prepared by cutting, and thus a plurality of holding member/effective composition raw material/peeling protective member laminates are prepared. Here, the cut-cooled non-deformed benefit composition raw material remains in a non-deformed state.
Other steps are the same as those described with reference to FIG.
For example, as shown in FIG. 5, in the step (D), the temperature is raised to room temperature of about 10° C. or higher, or the temperature is raised to room temperature or higher, so that the ingredients of the efficacy composition have stickiness and flexibility without fluidity. A patch comprising a holding member, a softening composition, and a peel-protecting member having a composition matured into a water-containing gel-like softening composition is formed, and the patch is contained in the packaging container. A storage package is obtained.
With this configuration, the effect of [Method effect D: Raw material of cutting-cooling non-deformation effect composition] described above can be obtained.

The cutting method for cutting the cooling non-deformable benefit composition 22b into a predetermined shape is not particularly limited. For example, as shown in FIGS. A method of cutting the article 22b into a desired planar shape and/or a method of cutting the mass of cooled non-deforming benefit composition 22b into a desired thickness shape is feasible. Further, as a cutting device, a flat plate type pressure cutting device, a flat plate type pressure cutting device, a roll type pressure cutting device or a roll type pressure cutting device can be used to cut into a predetermined shape.
The cut shape is not particularly limited, but for example, the thin plate sheet-like cooled non-deformable benefit composition 22b is cut into any desired shape to obtain the aged softening benefit composition 22.
An embodiment of the softening benefit composition 22 formed by cutting the thin sheet of cooled non-deformable benefit composition into a desired shape and aging step is shown in FIG. FIG. 10 is a schematic plan view showing the shape of the softening composition 22 contained in the patch contained in the patch containing package of one embodiment of the present invention. In the plan view, (A) of FIG. 10 is substantially rectangular, (B) is substantially heart-shaped, and (C) and (D) have a partially removed shape with a predetermined region removed. .
In the cutting step, the bulk chilled undeformed benefit composition 22b may also be cut into a plurality of pieces to form a plurality of cut chilled undeformed benefit compositions 22c.

<Construction containing water-soluble polymer>
In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can be carried out.
The softening composition is a water-containing gel-like softening composition containing at least water and a water-soluble polymer, and the softening composition has a flowable state at a first flow temperature. However, it has a non-deformed state to the extent that it does not deform at the second cooling non-deformation temperature that is lower than the first flow temperature, and has no fluidity at the third soft aging temperature that is higher than the second cooling non-deformation temperature. It is characterized by having the property of having a gel-like flexible state that maintains the shape after being changed into a shape, stickiness, and a flexible state.

This configuration provides the following effects.
[Method effect S: water-soluble polymer/water-containing gel-like softening effect composition]:
The softening composition 22 contains at least water and a water-soluble polymer, has a flowable state at a first flow temperature, and does not deform at a second cooling non-deformation temperature lower than the first flow temperature. The water-containing gel-like softening composition 22 has a degree of non-deformation, and has a non-fluid, flexible state at the third soft aging temperature obtained by raising the second cooling non-deformation temperature, and has adhesiveness. As a result, the aforementioned [Method Effect A: Adhesive storage of patch] can be obtained, and furthermore, the gel component of the water-containing gel-like softening composition 22 can be freely designed, and the patch 2 can be applied to the human body. In some cases, a pleasant cooling sensation due to water can be obtained, and the water-containing gel-like softening composition 22 is harmless to the human skin, so that a skin-friendly patch can be obtained.
Furthermore, the phenomenon that the water-containing gel-like softening composition 22 formed between the holding member 21 and the peeling protective member 23 protrudes from the edge between the holding member 21 and the peeling protective member 23 is remarkably suppressed, so that the adhesive patch can be removed. As a result, the inconvenience of not being able to easily remove the patch from the packaging container caused by the protruding water-containing gel-like softening composition sticking to the inner surface of the packaging container is also eliminated. Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.
Furthermore, the adhesive patch 2 having the desired performance can be stably mass-produced with high precision without fluctuations in the ratio of the contained component caused by the evaporation of water, which is the contained component, during aging. can be remarkably improved, patches of desired quality can be stably mass-produced, and a patch containing package 1 can be obtained that makes it possible to significantly reduce costs.
A crosslinked hydrogel softening composition is preferably used as the hydrogel softening composition.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can be carried out.
The softening composition 22 is a water-containing gel containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent for cross-linking the water-soluble polymer into a three-dimensional chemical structure in the chemical formula structure. The softening benefit composition, the water-soluble polymer contained in the ingredients of the benefit composition in the step (A), the step (B), and the step (C) exists in a non-crosslinked state, and the step (D) in the aging step, the water-soluble polymer is cross-linked by a chemical reaction between the water-soluble polymer and the cross-linking agent to generate a three-dimensional network chemical structure, thereby forming a gel-like soft state without fluidity. It is characterized by aging into a gel-like softening composition.

The crosslinkable water-soluble polymer is not particularly limited. At least one crosslinkable water-soluble polymer selected from the group consisting of cellulose, carboxyvinyl polymer, and salts thereof, and in the step (D), the crosslinkable water-soluble polymer is combined with the crosslinker. A patch provided with a holding member and a softening composition having a configuration in which the ingredients of the efficacy composition are crosslinked by a chemical reaction and thereby matured into a water-containing gel-like softening composition in a flexible state without fluidity. is formed, and a patch-containing package is obtained in which the patch is stored in the packaging container. These crosslinkable water-soluble polymers have crosslinkable functional groups in their chemical structural formulas, and are chemically crosslinked into a three-dimensional structure in an aqueous solution.
As salts, metal salts such as sodium, potassium, or lithium are desirable, and metal salts such as calcium, zinc, or magnesium can also be used. A compound having a methyl group, an ethyl group, or a propyl group can be used as the alkyl group of the alkyl cellulose. A carboxyvinyl polymer having crosslinkability can be used as the carboxyvinyl polymer.

By mixing a cross-linking agent such as a divalent metal ion compound or a trivalent metal ion compound, these cross-linkable water-soluble polymers are cross-linked into a network structure and/or a three-dimensional structure in the chemical structural formula, and flow. It is in a flexible and soft state without elasticity, and it is matured and changed to a gel state with stickiness as well as shape retention and water retention.
Examples of cross-linking agents include, but are not limited to, aluminum chloride, calcium chloride, alum, potassium alum, iron alum, calcium hydroxide, magnesium chloride, ferric sulfate, ammonium alum, aluminum glycinate, aluminum glycinate, and sulfuric acid. Aluminum, aluminum potassium sulfate, aluminum ammonium sulfate, dihydroxy aluminum aminoacetate, aluminum hydroxide, aluminum silicate, aluminum phosphate, aluminum stearate, aluminum lactate, aluminum acetate, iron citrate, magnesium oxide, calcium oxide, aluminum hydroxide Magnesium, magnesium aluminometasilicate, and the like can be mentioned, and can be used alone or in combination of two or more.
A fluid softening effect composition containing water, a water-soluble polymer, and a cross-linking agent is such that the water-soluble polymer has a chemical structure of It is crosslinked into a mesh structure or a three-dimensional structure, and is matured and transformed into a flexible composition having shape retention properties without fluidity.
By selecting and including the type of cross-linking agent, it is possible to cross-link the water-soluble polymer at a desired temperature or speed. For example, in the step (D) in the method for producing a patch containing package, the ingredient composition containing the crosslinkable water-soluble polymer is heated at a temperature range of about 10°C to about 30°C around room temperature to obtain the water-soluble polymer. can be crosslinked into a network structure and/or three-dimensional structure in the chemical structural formula, and can be aged and changed to a gel state that has shape retention and water retention as well as stickiness in a flexible and soft state without fluidity. is. In addition, the cross-linking speed is remarkably slow at about 10° C. or less, and the cross-linking is accelerated in the temperature range of about 30° C. to 60° C., so that the manufacturing method can be carried out in a short time.

In the water-containing gel-like softening composition, the contents of water, the crosslinkable water-soluble polymer, and the cross-linking agent are not particularly limited. about 10% to about 98% by weight (preferably about 30% to about 95% by weight), and the content of the crosslinkable water-soluble polymer is about 0.5% to about 20% by weight (preferably about 1% to about 10% by weight), with a crosslinker content of about 0.001% to about 1% (desirably about 0.002% to about 0.5%). It is possible.
If the water content is less than about 10% by weight, or if the crosslinkable water-soluble polymer content exceeds about 20% by weight, the crosslinkable water-soluble polymer cannot be completely dissolved. There is a tendency not to obtain a softening benefit composition with the desired physical properties.
When the water content exceeds about 98% by weight, or when the content of the crosslinkable water-soluble polymer is less than about 0.5% by weight, the desired flexibility, shape retention, and tackiness can be achieved. There is a tendency not to obtain a gel-like softening benefit composition.
When the content of the cross-linking agent is about 0.001% by weight, the cross-linking reaction is insufficient, and there is a tendency that a water-containing gel-like softening composition exhibiting desired flexibility, shape retention and adhesiveness cannot be obtained. There is If the content of the cross-linking agent exceeds about 1% by weight, a rapid cross-linking reaction occurs during mixing and preparation of the active composition raw materials, making it impossible to obtain a functional composition raw material having fluidity. There is a tendency to not be able to laminate the benefit composition ingredients as desired.

In addition to one or more of the crosslinkable water-soluble polymers described above, it is also possible to use a non-crosslinkable, non-crosslinkable water-soluble polymer in combination.
Ingredients for the effective composition include a crosslinkable water-soluble polymer, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide, starch-acrylic acid copolymer, alkylcellulose, grafted starch, alginic acid, gelatin, carrageenan, agar, gelatin, and pectin. , locust bean gum, xanthan gum, gum arabic, tragacanth gum, gellan gum, ernest gum, agarose, dextrin, glucomannan, polyglutamic acid, and salts of these synthetic and/or natural water-soluble polymers A configuration containing the above non-crosslinkable water-soluble polymer can also be implemented.
By appropriately selecting the types of cross-linkable water-soluble polymer, cross-linking agent, non-cross-linkable water-soluble polymer, other additives, etc., and the molecular weight, degree of polymerization, etc. of these water-soluble polymers, the desired adhesion can be obtained. A emollient composition can be prepared by designing it as desired, having properties, pliability, and retention.

The structure containing the above-described crosslinkable water-soluble polymer has the aforementioned [Method Effect A] and also provides the following [Method Effect C-a] and [Method Effect C-b] effects.
[Method Effect Sa-a: Crosslinkable water-soluble polymer, water-containing gel-like softening composition, room temperature aging]:
In this configuration, the above-mentioned [Method effect S] can be obtained, and by designing and containing both types of the crosslinkable water-soluble polymer and the crosslinker, crosslinkage and aging can be performed at the desired temperature. It is possible to obtain a water-containing gel-like softening composition. For example, it is possible to obtain a crosslinked water-containing gel-like softening composition at a temperature of about 30°C or less without having to raise the temperature to a temperature above about 30°C. That is, in step (A), there is a "fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a flowable state in an atmosphere of room temperature of about 10°C to about 30°C", and (D ) in the step “Aging and changing the efficacy composition raw material constituting the laminate storage package into a flexible efficacy composition in a flexible state without fluidity in an atmosphere of about 10° C. to about 30° C. of room temperature. and a maturing step of adhering and bonding the softening composition to the holding member to prepare a holding member/softening composition/peeling protective member laminate in which the softening composition is adhered and joined to the holding member, whereby the efficacy A patch comprising a holding member, a softening composition, and a peeling protection member having a configuration changed by aging a composition raw material into a softening composition having a flexible state without fluidity is formed, and the patch is formed. A patch-containing package stored in the packaging container is obtained." can be implemented. In other words, in both the (A) process and the (D) process, it is possible to carry out the manufacturing in an atmosphere of about 10° C. to about 30° C. of room temperature.
In addition, with this configuration, it is possible to obtain the effect of suppressing evaporation of water due to temperature rise, preventing fluctuations in the contained composition, and suppressing thermal deterioration of the contained components due to temperature rise.
Furthermore, the gel component and medicinal components of the hydrous gel composition can be freely designed, and when the patch is applied to the human body, the patch exhibits a moderate cooling sensation due to the hydrous component and a medicinal effect due to the medicinal component. In addition, a patch which can minimize skin irritation and which is gentle on the skin is obtained.
Further, in the state of being housed in the packaging container, the ingredients of the efficacy composition are crosslinked to form a three-dimensional network chemical structure, and the matured water-containing gel-like softening efficacy composition having a gel-like soft state without fluidity. Therefore, it is possible to remarkably suppress changes in the content composition of the efficacy composition due to evaporation of moisture, etc. during aging, and to stably produce a patch having desired adhesiveness and flexibility. Become.
Furthermore, by selecting the type of cross-linking agent, it becomes possible to cross-link at around room temperature, so that the softness effect composition is cross-linked by cross-linking the effect composition raw materials in the state of being housed in the packaging container. can be produced, and the production time can be significantly reduced compared to the case where the crosslinked patch is stored in a packaging container.
In addition, the cost of electric power required for heating and raising the temperature is also reduced, resulting in the effect of being able to manufacture at low cost.
In addition, by selecting and containing the desired type of cross-linking agent, the cross-linking rate is remarkably slow at about 30° C. or less, and the cross-linking is promoted in the temperature range of about 30° C. to 60° C., resulting in a production process in a short time. is also feasible. By this method, the fluidity of the fluid efficacy composition raw material is maintained for a long time, so the time from the preparation of the fluid efficacy composition raw material in step (A) to the laminate packaging step in step (C) can be adjusted as desired. A designable manufacturing method is obtained.

[Method Effect Sa-b: Crosslinkable water-soluble polymer, water-containing gel-like softening composition, suppression of protrusion]:
By the manufacturing method for forming the water-containing gel-like softening composition containing the above-described crosslinkable water-soluble polymer, the aforementioned [Method effect S] can be obtained, and furthermore, the holding member 21 and the peel protection member 23 can be separated from each other. The phenomenon that the water-containing gel-like softening composition 22 formed between the holding member 21 and the peeling protective member 23 protrudes from the edge between the holding member 21 and the peeling protective member 23 is remarkably suppressed, and a patch can be obtained. The inconvenience that the patch 2 cannot be easily removed from the packaging container 3 due to the efficacy composition 22 sticking to the inner surface of the packaging container 3 is also eliminated, and furthermore, when the patch 2 is applied to the human skin, 2. A patch storage package that significantly suppresses the user's discomfort due to stickiness on the surface of the patch 2 caused by the protruding water-containing gel-like softening composition 22 not being supported by the holding member 21. 1 can be produced.

In particular, in the configuration containing a hydrogel softening composition containing water, a crosslinkable water-soluble polymer, and a crosslinker, the first flow temperature is in the range of about 10° C. to about 30° C. of room temperature, and the second A configuration is feasible in which the second cooling non-deformation temperature is in the temperature range of less than about 5°C and the third soft aging temperature is in the range of about 10°C to about 30°C of normal temperature. In this configuration, by desirably designing and including both types of the crosslinkable water-soluble polymer and the cross-linking agent, there is no step of raising the temperature to a temperature exceeding about 30°C, and the temperature is reduced to about 30°C or less. It is possible to obtain a hydrogel softening composition which is crosslinked at temperature.
That is, in the step (A), there is a "fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a flowable state in an atmosphere of room temperature of about 10°C to about 30°C", and (D ) in the step “Aging and changing the efficacy composition raw material constituting the laminate storage package into a flexible efficacy composition in a flexible state without fluidity in an atmosphere of about 10° C. to about 30° C. of room temperature. and a maturing step of adhering and bonding the softening composition to the holding member to prepare a holding member/softening composition/peeling protective member laminate in which the softening composition is adhered and joined to the holding member, whereby the efficacy A patch comprising a holding member, a softening composition, and a peeling protective member having a configuration changed by aging a composition raw material into a softening composition having a flexible state without fluidity is formed, and the patch is formed. A patch-containing package stored in the packaging container is obtained." can be implemented.
In other words, in both the (A) process and the (D) process, it is possible to carry out the manufacturing in an atmosphere of about 10° C. to about 30° C. of room temperature.
With this configuration, it is possible to obtain the effect of suppressing the evaporation of water due to temperature rise, preventing the fluctuation of the contained composition, and suppressing the thermal deterioration of the contained components due to the temperature rise. In addition, the cost of electric power required for heating and raising the temperature is also reduced, resulting in the effect of being able to manufacture at low cost.

<Regarding the configuration provided with the softening composition containing a water-soluble polymer and not containing a cross-linking agent>
As the softening composition, it is also possible to implement a configuration comprising a softening composition that contains a crosslinkable water-soluble polymer and/or a non-crosslinkable water-soluble polymer and does not contain a cross-linking agent.
As the water-soluble polymer, the aforementioned crosslinkable polymer and/or non-crosslinkable water-soluble polymer can be used.

The flow effective composition raw material 1a containing a crosslinkable water-soluble polymer and/or a non-crosslinkable water-soluble polymer and not containing a cross-linking agent, for example, has a first flow temperature of about 10°C to about 70°C (preferably is about 15° C. to about 60° C.), and in a low temperature range of about 5° C. or less (preferably about -20° C. to about 3° C.) below the low temperature as the second cooling non-deformation temperature, It becomes non-flowable, cuttable, and non-deformable to the extent that it does not deform during cutting, and from the non-deformed state to a third soft aging temperature of about 10 ° C. to about 50 ° C. (preferably about 15 ° C. to about 40 ° C.) ° C.), it is possible to carry out a material that has the property of being chemically crosslinked to form a non-fluid, water-containing gel-like softening composition.
The first flow temperature, the second cooling non-deformation temperature, and the third soft aging temperature differ depending on the type of the flow benefit composition raw material used.

As the first flow temperature becomes about 10°C or less, the fluidity tends to decrease, the workability such as mixing of raw materials tends to deteriorate, and the productivity tends to deteriorate. Inconveniences such as deterioration of contained components due to heat or evaporation of contained moisture tend to occur.
In the temperature range where the second cooling non-deformation temperature exceeds about 5°C, as the temperature rises, the fluidity gradually increases, and during the cutting operation, there is a tendency that the effective composition ingredients re-adhere and cannot be cut accurately. In addition, there is a tendency that the efficacy composition raw material adheres to the blade used for cutting, resulting in poor productivity. If the second cooling non-deformation temperature is about -20°C or less, it can be easily cut, but the electric power cost for setting the temperature to about -20°C or less becomes expensive, and the manufacturing cost increases. Tend.
When the third softening aging temperature is about 10°C or less, the softening effect composition tends to become slightly hard and gives a feeling of discomfort when applied to the human body. The composition tends to be too soft, giving an uncomfortable feeling during use.

[Method Effect C-c: Water-soluble polymer/no cross-linking agent/water-containing gel-like softening effect composition]:
A configuration comprising a softening composition containing a crosslinkable water-soluble polymer and/or a non-crosslinkable water-soluble polymer and containing no cross-linking agent as the softening composition,
In addition to obtaining the aforementioned [Constructive Effect A: Adhesive storage of the adhesive patch], the gel component of the water-containing gel-like softening composition 22 can be freely designed, and when the adhesive patch 2 is applied to the human body, A comfortable cooling sensation due to water can be obtained, and the water-containing gel-like softening composition 22 is harmless to the human skin, so that a skin-friendly patch can be obtained.
Furthermore, the phenomenon that the water-containing gel-like softening composition 22 formed between the holding member 21 and the peeling protective member 23 protrudes from the edge between the holding member 21 and the peeling protective member 23 is remarkably suppressed, so that the adhesive patch can be removed. As a result, the inconvenience of not being able to easily remove the patch from the packaging container caused by the protruding water-containing gel-like softening composition sticking to the inner surface of the packaging container is also eliminated. Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.
Furthermore, the adhesive patch 2 having the desired performance can be stably mass-produced with high precision without fluctuations in the ratio of the contained component caused by evaporation of the contained component water, etc., during aging. can be remarkably improved, patches of desired quality can be stably mass-produced, and a patch containing package 1 can be obtained that makes it possible to significantly reduce costs.
A crosslinked hydrogel softening composition is preferably used as the hydrogel softening composition.

<Regarding softening composition containing medicinal ingredient, pH adjuster, preservative and other additives>
As the softening composition 22, a softening composition containing a medicinal ingredient having percutaneous absorbability and exhibiting a medicinal effect that the medicinal ingredient exhibits when applied to the skin of the human body can be used.
The medicinal ingredients are not particularly limited, but for example, indomethacin, loxoprofen, loxoprofen sodium, ketoprofen, diclofenac, diclofenac sodium, piroxicam, suprofen, ibuprofen, ketorolac, lidocaine, flurbiprofen, terbinafine, capsaicin, plantain extract, mefenamic acid, Dipotassium glycyrrhizinate, menthol, camphor, hyaluronic acids, salicylates, arbutin, tocopherol acetate, allantoin, vitamins, azulenes, acrinol, psyllium extract, other plant extracts, arbutin, tocopherol acetate, vitamin Cs, water-soluble azulene, Pain relievers such as polyphenols, ecozymes, placenta extracts, antiphlogistic agents, nutritional supplements, tranquilizers, warming agents, cooling agents, moisturizing agents, whitening agents, agents for eliminating skin stains and freckles, other percutaneously absorbable agents, etc. can be used.

The following effects are obtained by the composition containing the above medicinal ingredients.
[Method effect set: active ingredient-containing softening effect composition]:
As the emollient composition 22, a patch storage package that exhibits a medicinal effect corresponding to the contained medicinal ingredient can be obtained by further containing a percutaneously absorbable medicinal ingredient.

In addition to these medicinal ingredients, preservatives, bactericides, aromatic oils, fragrances, fragrances, coloring agents, antioxidants, antioxidants, antiseptics, antiseptics, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, antiseptic agents, anti-oxidants, Skin absorption enhancers, ultraviolet absorbers, inorganic fillers, polyhydric alcohols, silicone oils, surfactants, viscosity modifiers, fine powders, and other desired additives may also be added.
These ingredients are gradually transferred from the water-containing gel-like softening composition to the application site of the body, and the effects attributed to these ingredients can be obtained along with the cold-retaining and moisturizing effects.

The above-mentioned aroma oils and fragrances are not particularly limited, but for example, essential oil components (essential oils) generally used in aromatherapy can be used as they are. Essential oil components include, for example, those described in Wonder Cellar, "84 Essential Oil Components for Aromatherapy", Fragrance Journal. Anise, chamomile, carrot seed, grapefruit, sage, geranium, celery, thyme, tarragon, turpentine, frankincense, violet, pine, parsley, lemon, lemongrass, rosemary, laurel, cornflowers, almonds, camphor, Examples include, but are not limited to, extracts from plum, dandelion, chimo, black rose, mint, peach, eucalyptus, coix seed, lavender, forsythia, and the like.

Furthermore, in the water-containing gel-like softening composition, a composition that additionally contains a lower alcohol that enhances the cooling and cold insulation effect by generating heat due to volatilization, a cooling agent such as menthol and peppermint oil, and a warming agent such as capsaicin and hot pepper extract. is also feasible. In addition, in the above water-containing gel-like softening composition, a pH adjusting agent such as citric acid, tartaric acid, sodium hydroxide, lactic acid, etc. is added to adjust the pH to a range of 4 to 10, more preferably pH 6 to 8. should be adjusted within the range of

In order to obtain the desired adhesiveness and flexibility of the water-containing gel-like softening composition, a composition containing a tackifier, a softening agent, a plasticizer, etc. can also be implemented. Examples of tackifiers include, but are not limited to, rosin, hydrogenated rosin, rosin ester, hydrogenated rosin ester, polyterpene, phenolic resin, xylene resin, other aliphatic resins, petroleum resins, and alicyclic hydrocarbons. Resin or the like can be used.
Softeners and plasticizers include polybutene, polyisobutylene, silicone, vaseline, solid paraffin, liquid paraffin, limonene, pinene, almond oil, olive oil, camellia oil, persic oil, peppermint oil, sesame oil, soybean oil, cottonseed oil, and corn oil. , egg yolk oil, safflower oil, etc. can be used.

Skin absorption enhancers include lanolin, liquid paraffin, beeswax, menthol, limonene, pinene, piperitone, terpinol, carveol, jojoba oil, almond oil, olive oil, camellia oil, persic oil, peppermint oil, sesame oil, soybean oil, and mink oil. , cottonseed oil, corn oil, etc. can be used.
Glycerin, propylene glycol, butylene glycol, dipropylene glycol, octanediol, polyethylene glycol, sorbitol, and the like can be used as polyhydric alcohols.
As the silicone oil, methylsiloxane, methylphenylpolysiloxane, dodecamethylpolysiloxane and the like can be used.

<Water-containing gel-like softening effect composition: Concerning the configuration provided with the cooled non-deformable cooling effect composition raw material>
In particular, in a configuration containing a water-containing gel-like softening composition containing water, a crosslinkable water-soluble polymer, and a cross-linking agent, the water-containing gel composition raw material 22a having fluidity is cooled to a non-fluidity It is possible to implement a configuration including a lamination member lamination step of laminating the cooled non-deformed benefit composition raw material 22b in a fluid form or non-deformed state on the holding member, and this configuration provides the following effects.
[Method effect: crosslinkable water-soluble polymer, water-containing gel-like softening composition, cooling]:
The above [Method Effect A], [Method Effect C-a], and [Method Effect C-b] are obtained, and in particular, the above-mentioned [Method Effect C: Cooling non-deformation effect composition raw material] is remarkably exhibited. .

<Water-containing gel-like softening effect composition: Concerning the configuration provided with the raw material of the cut cooling non-deforming effect composition that has been cooled and cut>
In particular, in a configuration containing a water-containing gel softening composition containing water and a crosslinkable water-soluble polymer, the water-containing gel composition raw material 22a having fluidity is cooled to obtain a non-fluid form or It is possible to implement a configuration including a predetermined shape forming step of cutting the prepared cooled non-deformed benefit composition raw material 22b in the non-deformed state to prepare the cut cooled non-deformed benefit composition raw material 22c. The following effects are obtained.
[Method effect: water-soluble polymer, water-containing gel-like softening composition, cooling, cutting]:
The water-containing gel composition raw material 22a having fluidity is cooled to prepare a cooled non-deformable effect composition material 22b in a non-fluid or non-deformed state, which is cut and cooled. (Method effect S: water-soluble polymer/water-containing gel-like softening effect composition) is obtained by a configuration including a predetermined shape forming step for preparing the composition raw material 22c, and cutting and cooling into a predetermined shape by cutting with high accuracy. A non-deforming benefit composition ingredient can be obtained.
Furthermore, the aforementioned [Method effect A: Adhesive storage of the patch] and [Method effect C: Cooling non-deforming effect composition raw material] are obtained, and the cooling non-deformable effect composition raw material 22b is cut into a predetermined shape. In the case of providing a predetermined shape forming step for preparing the cooled non-deformable effective composition raw material 22c, it can be accurately cut into a desired planar shape and thickness shape, and is stored in close contact with the packaging container. Therefore, the desired shape does not change during the aging process, and a patch having a desired shape can be easily produced.
In addition, when cutting the water-containing gel-like softening composition 22 having adhesiveness after aging, it is generally difficult to cut easily due to the adhesiveness, and the water-containing gel-like softening composition is generally difficult to cut due to the adhesiveness. There is a problem that it is difficult to cut repeatedly due to adhesion of the residue of the composition 22, but by the method of the present invention, the above problem can be solved, and the water-containing material can be cut into a desired shape. The gel softening composition 22 can be easily cut without any inconvenience such as suppressing the amount of deposits such as residues of the gel softening composition 22. As a result, the hydrogel softening composition 22 laminated on the holding member can be cut to a desired thickness. The thickness, area, shape, weight, lamination position, etc. can be formed with high accuracy. In addition, since the water-containing gel-like softening composition 22 that has been aged while being housed in a sealed packaging container is obtained, there is no change in the ratio of the constituent components contained, and there is no fluctuation in the ratio of the contained components. Thus, it is possible to obtain an adhesive patch storage package having a high quality, remarkably improve the yield of non-defective products, stably mass-produce patches having a desired quality, and significantly reduce costs.
Furthermore, the drawback that the hydrous gel composition adheres to the blade used for cutting is suppressed, the occurrence of defects during mass production is suppressed, and the productivity is remarkably improved.

<Regarding the manufacturing method of the adhesive patch storage package in which a plurality of efficacy flexible compositions are laminated on the planar region of the holding member>
In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
The softening effect composition 22 includes a plurality of types of softening effect composition 22 containing composition components different from each other. and has the following configuration.
(A) A fluid efficacy composition raw material preparation step of preparing a plurality of types of fluid efficacy composition raw materials 22a having a flowable state, wherein each of the plurality of types of fluid efficacy composition raw materials 22a is prepared. The raw material 22a contains compositional components different from each other.
(B) On a predetermined position area of the surface of the holding member 21, each of the fluid efficacy composition raw material 22a and the peeling protection member 23 are laminated with the peeling protection member 23 positioned on the surface side, and the holding member / A lamination member lamination step for preparing the efficacy composition raw material/peeling protective member laminate, wherein each of the flowing efficacy composition raw materials 22a has a predetermined shape and fluidity, and (i) each of the flowing efficacy composition The material ingredients 22a are stacked adjacent to each other in the plane area of the holding member 21, or (ii) the respective flowing beneficial composition ingredients 22a are stacked in overlapping positions in the stacking direction of the holding member 21.
(C) The holding member/effective composition raw material/releasing member laminate is placed in a packaging container 3, and the packaging container 3 is placed on the holding member/effective composition raw material/releasing member laminate. A laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container 3 so that it deforms along the shape and comes into close contact, wherein each of the above-mentioned flowing efficacy compositions The raw material 22a has a predetermined shape and maintains fluidity.
(D) Each fluid efficacy composition raw material 22a constituting the laminate containing package is joined to the holding member 21, and each of the fluid efficacy composition raw materials 22a is joined to each other, resulting in a non-fluid, flexible state. The softening composition 22 is aged, and the softening composition is adhered and bonded to the holding member, and the softening composition 22 is adhered and bonded to the holding member 21. The holding member, softening composition, and peeling A maturing step of preparing a protective member laminate, whereby each flowable effect composition raw material 22a is aged to each softening effect composition 22 having a non-flowable soft state. A patch-containing package 1 is obtained in which a patch provided with a material/peeling protective member is formed and the patch 2 is stored in the packaging container 3 .

This configuration provides the following effects.
[Method effect: Multiple types of fluid effect composition raw materials]:
In addition to obtaining the aforementioned [Method Effect A: Adhesive storage of the adhesive patch], the packaging container is deformed along the shape of the holding member, the active composition raw material, and the peeling member laminate, and in a state of being in close contact, a plurality of types of flows can be obtained. Since the efficacy composition raw material 21a is changed and matured into a plurality of types of efficacy compositions 22, a plurality of types of softening efficacy compositions with different compositional components are adjusted to desired thickness, area, shape, weight, lamination position, etc. , it becomes possible to form a plurality of types of softening composition with high accuracy, and to stably mass-produce the composition without changing the ratio of the constituent components. For example, in the manufacture of a patch containing multiple types of active ingredients with different compatibility and solubility with other ingredients, multiple types of active ingredient raw materials 22a that are optimal for each active ingredient are prepared and used. A desired adhesive patch 2 can be easily manufactured by arranging a plurality of types of efficacy composition raw materials 22a in the planar region and/or in the stacking direction.
Furthermore, in a state in which the packaging container 3 is deformed along the shape of the holding member/beneficial composition raw material/peeling member laminate and brought into close contact, the fluid beneficial composition raw material 22a having a plurality of types of flowable fluid states is added. In order to be aged and changed to the softening effect composition 22 in a soft state without fluidity, and to maintain the shape of the multiple types of fluid effect composition raw materials 22a during aging, the holding member 21 is separated. Plural types of flow benefit composition raw materials 22a sandwiched between the protective member 23 and the protrusion from between the holding member 21 and the peeling protective member 23 are prevented. As a result, the inconvenience of not being able to easily remove the adhesive patch 2 from the packaging container 3 due to the protruding softening composition 22 adhering to the inner surface of the packaging container 3 is eliminated. Furthermore, when the patch 2 is applied to the skin of the human body, the softening composition 22 protruding out is not supported by the holding member 21 and the surface of the patch 2 is tacky. Pleasure is eliminated and can be used comfortably.

In particular, the following effects can be obtained in a configuration in which a plurality of types of softening compositions are placed adjacent to each other on the surface region of one holding member.
[Method effect car-a: multiple types of fluid effect composition raw materials/plane]:
In addition to the above [Method effect: multiple types of flowing benefit composition raw materials], areas of the softening benefit composition having different compositional components are placed adjacent to each other on the surface area of one holding member. As a result, it is possible to stably mass-produce patches having desired quality. For example, a softening composition area with a cooling effect, a softening composition area with analgesic effect, a softening composition area with strong adhesiveness, etc. may be alternately formed in the lateral direction of the surface area of the holding member. Thus, it is possible to obtain an adhesive patch package that exhibits desired efficacy and has excellent adhesive performance.

In particular, the following effects can be obtained in a configuration in which a plurality of types of softening composition are placed in overlapping positions in the stacking direction on the surface region of one holding member.
[Method effect car-b: multiple types of flow effect composition raw materials and lamination]:
In addition to the above [method effect: multiple types of flowable effect composition raw materials], it is also possible to easily create a patch having a flexible effect composition having different compositional components overlapping each other in the stacking direction on the surface of one patch. As a result, patches of desired quality can be stably mass-produced. For example, in a patch containing multiple types of active ingredients with different solubility and compatibility, multiple types of effective composition raw materials that are optimal for each active ingredient are prepared and arranged in the stacking direction to exhibit the desired effect. A patch can be easily produced.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the configuration shown in FIGS. 7 and 8 can also be carried out.
FIGS. 7 and 8 are process explanatory diagrams and schematic process diagrams for explaining other manufacturing processes of the method for manufacturing a patch containing packaged product according to an embodiment of the present invention, and FIG. are laminated at positions overlapping each other in the lamination direction, and FIG.
Another method for manufacturing a patch containing package of the present invention has the following configuration.
The softening composition 22 includes a plurality of softening compositions containing different components.
Each of the plurality of types of softening composition 22 has a fluid state in which it can flow at the first fluidizing temperature and is not deformed at the second cooling non-deformation temperature which is lower than the first fluidizing temperature. and has a flexible state in which it is changed to a non-fluid form without fluidity at the third soft aging temperature, which is the second cooling non-deformation temperature.
The effective composition material 22a comprises a plurality of types of cooled non-deformed effective composition materials 22b cooled to the second cooled non-deformed temperature.
And it has the following steps.
(A) a step of preparing a plurality of types of fluid benefit composition ingredients 22a having a flowable state at a first fluid temperature, where each of the plurality of types of fluid benefit composition ingredients 22a is prepared; contain composition components different from each other, and each of the plurality of types of fluid efficacy composition ingredients 22a is cooled to a second cooling non-deformation temperature at which it is in a non-deformed state. a cooling prescribed shape forming step for preparing each of the cooled non-deformed effective composition raw materials 22b in an undeformed state having a prescribed shape.
wherein said each cooled undeformed benefit composition feedstock 22b has an undeformed state, (i) each cooled undeformed benefit composition feedstock 22b has a predetermined shape without being cut, and/ or (ii) cutting each chilled undeformed benefit composition stock 22b such that each chilled undeformed benefit composition stock has a predetermined shape cut into a predetermined shape.
(B) The cooling non-deforming effect composition raw material and the peeling protection member 23 are laminated on a predetermined position area on the surface of the holding member with the peeling protection member 23 positioned on the surface side. a lamination member lamination step for preparing a benefit composition raw material/release protection member laminate, wherein said respective chilled non-deformed benefit composition raw material maintains an undeformed state, and (i) each cooled undeformed benefit composition The ingredients are stacked adjacent to each other in planar regions of the retaining member, and/or (ii) each chilled non-deformable benefit composition ingredient is stacked in an overlapping position in the stacking direction of the retaining member.
(C) The holding member/effective composition raw material/release member laminate is placed in a packaging container, and the packaging container is formed into the shape of the holding member/effective composition raw material/release member laminate. a laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container so as to deform along and adhere to, wherein the cooled non-deformed benefit composition The raw material remains undeformed.
(D) bonding each of the fluid benefit composition materials located on the surface of the holding member to the retaining member and bonding each of the fluid benefit composition materials to each other so that each flexible material is in a non-fluid, flexible state; The benefit composition is aged and the softening benefit composition is adhered and bonded to the holding member to prepare a holding member/softening benefit composition/peeling protective member laminate in which the softening benefit composition is adhered and bonded to the holding member. Aging step, whereby each fluid composition raw material has a non-fluid, flexible state, and affixing comprising a holding member, a flexible composition, and a peel protection member, each having a structure aged into each flexible composition. A patch-containing package is obtained in which a patch is formed and the patch is stored in the packaging container.
7 and 8, the step (A) includes "(ii) cutting each cooled non-deformed benefit composition raw material 22b so that each cooled non-deformed benefit composition raw material has a predetermined shape. The configuration of "(i) each of the cooled non-deformed active composition ingredients 22b has a predetermined shape without being cut" is shown in the figure. It has not been.

In the above step (A), the following effects can be obtained in the configuration where "(i) each of the cooled non-deformed benefit composition raw materials 22b has a predetermined shape without being cut".
[Method effect ki: multiple types of cooling non-deforming effect composition raw materials/cooling]:
In addition to obtaining the aforementioned [Method Effect A: Adhesive storage of the adhesive patch], multiple types of cooling are performed in a state in which the packaging container is deformed along the shape of the holding member, the active composition raw material, and the peeling member laminate so as to be in close contact. Since the raw material of the non-deformable benefit composition is aged, it is possible to form a plurality of types of the softening benefit composition 22 with different compositional components in desired thickness, area, shape, weight, lamination position, etc., with remarkably high precision. In addition, mass production can be stably performed without fluctuations in the proportion of the compositional components contained. For example, in the manufacture of a patch containing multiple types of active ingredients with different compatibility and solubility with other ingredients, multiple types of active ingredient ingredients that are optimal for each active ingredient are prepared, A desired patch can be easily produced by arranging a plurality of types of effective composition raw materials in a planar region and/or in a stacking direction.
Furthermore, the cooling non-deformable beneficial composition has a plurality of types of cooled and solidified non-deformed states in a state in which the packaging container is deformed along the shape of the holding member/effective composition raw material/releasing member laminate and closely attached. Since the raw material 22 is aged and changed into a flexible composition in a soft state without fluidity, the shape of the plurality of types of cooled non-deformed composition raw materials during aging is maintained. It is possible to prevent the plurality of types of cooling non-deforming active composition raw materials sandwiched between the peeling protective member from squeezing out from between the holding member and the peeling protective member. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated. Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use. In addition, it is possible to stably and accurately mass-produce patches with the desired performance without changing the ratio of the ingredients due to the evaporation of the ingredients during aging, and as a result, the yield of non-defective products can be significantly improved. Therefore, it is possible to stably mass-produce patches containing packages having desired quality, and to significantly reduce costs.

In particular, in the above step (B), the following effects can be obtained in a configuration in which a plurality of types of softening compositions are placed adjacent to each other on the surface region of one holding member.
[Method effect key-a: multiple types of cooling non-deforming effect composition raw materials/cooling/plane]:
In addition to the above [method effect g: multiple types of cooling non-deformation effective composition raw materials/cooling], a patch having regions of different composition components placed at positions adjacent to each other on the surface region of one patch As a result, it is possible to stably mass-produce patches having desired quality. For example, by alternately forming a patch region with a cooling effect, a patch region with an analgesic effect, a patch region with strong adhesiveness, etc., in the lateral direction of the surface region of the holding member, a desired shape can be obtained. It is possible to obtain an adhesive patch package that exhibits efficacy and has excellent adhesive performance.

In particular, in the step (B), the following effects can be obtained in a configuration in which a plurality of types of softening compositions are laminated on the surface region of one holding member.
[Method effect key-b: multiple types of cooling non-deformation effective composition raw materials/cooling/lamination]:
In addition to the above [Method Effect G: Multiple types of cooling non-deforming effective composition raw materials/cooling], it is possible to easily form patches having different compositional components by overlapping each other in the stacking direction on the surface of one patch. As a result, patches of desired quality can be stably mass-produced. For example, in a patch containing multiple types of active ingredients with different solubility and compatibility, multiple types of cooling non-deformable active ingredient raw materials that are optimal for each active ingredient are prepared and arranged in the stacking direction to achieve desired results. An effective patch can be easily produced.

(ii) cutting each of the undeformed cooled benefit composition raw materials in the step (A) so that each cooled undeformed benefit composition raw material has a predetermined shape cut into a predetermined shape; By having it, the following effects can be obtained.
[Method effect key-c: multiple types of cooling non-deforming effect composition raw materials/cooling cutting]:
In particular, (ii) cutting each cooled undeformed benefit composition stock 22b such that each cooled undeformed benefit composition stock has a predetermined shape cut into a predetermined shape, In addition to the above (method effect ki: multiple types of cooling non-deformation effect composition raw materials/cooling cutting), deformation during cutting is further suppressed, making it possible to easily cut into desired shapes with high precision, and complex It can be accurately cut into a desired planar shape and thickness shape having a shape, and since it is stored in close contact with the packaging container, the desired shape does not change even during the aging process, and the desired shape It becomes possible to easily manufacture a patch having It is possible to form multiple types of softening compositions with different compositional components with high precision in desired thickness, area, shape, weight, lamination position, etc., and the ratio of the composition components contained can be stably mass-produced with high precision without fluctuations in patch products. For example, a first shape of the softening composition having a strong adhesive force is laminated on the surface of the holding member, and a second shape that exhibits a cooling effect or an analgesic effect is formed on the inner region of the surface of the first shape of the softening composition. By layering and forming the emollient composition, it is possible to obtain a patch having a strong adhesive force in the periphery and a cooling effect or analgesic effect in the inner region.

<Regarding the method for manufacturing the patch storage package in which the packaging container is deformed and adheres closely to the shape of the patch>
In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
In the step (C), the holding member/effective composition raw material/release member laminate is placed in a packaging container, and the pressure inside the packaging container is reduced below atmospheric pressure. a laminate packaging step of sealing the opening of the packaging container to prepare a laminate storage package in which the inside of the packaging container is formed in a reduced pressure state lower than the atmospheric pressure, whereby the packaging container Due to the pressure difference between the inside and the outside of the packaging container, the holding member/effective composition raw material/peeling protection member laminate adheres along the shape of the laminate, resulting in a deformed laminate containing package.
FIG. 6 is a schematic process diagram of a method for manufacturing a patch containing package according to an embodiment of the present invention. The opening of the packaging container is sealed so that the packaging container deforms along the shape of the holding member/effective composition raw material/peeling member laminate in the state of being positioned in the position of An example of "laminate packaging process for preparing a laminate containing package" is schematically shown.
As shown in FIG. 6(A), in the step (C), the holding member/effective composition raw material/peeling member laminate is placed in the packaging container 3 while being positioned in the packaging container 3. The opening of the packaging container 3 is sealed while the inside is in a state of reduced pressure lower than atmospheric pressure to prepare a laminate containing package in which the inside of the packaging container is formed in a reduced pressure state lower than atmospheric pressure In this way, the packaging container 3 is tightly adhered along the shape of the holding member/effective composition raw material/peeling protective member laminate due to the difference in air pressure between the inside and outside of the packaging container. A deformed laminate containing package is obtained.

This configuration provides the following effects.
[Method effect: decompression adhesion]:
The opening of the packaging container 3 is sealed while the holding member/effective composition raw material/releasing member laminate is positioned in the packaging container and the interior of the packaging container is reduced to a pressure lower than the atmospheric pressure. and a laminate packaging process for preparing a laminate containing package in which the inside of the packaging container is in a reduced pressure state lower than the atmospheric pressure, so that the packaging container 3 is separated from the inside and outside of the packaging container. To easily obtain a laminate containing package product in which the packaging container 3 is easily brought into close contact along the shape of the holding member/effective composition raw material/peeling protective member laminate due to the pressure difference between the As a result, it is possible to stably mass-produce the adhesive patch containing package 1 in which the packaging container 3 is closely attached along the shape of the adhesive patch 2 .
In particular, in a patch comprising a holding member made of a porous material having a finely uneven surface as the holding member 21, due to the pressure difference between the inside and outside of the packaging container, the non-woven fabric having a finely uneven surface becomes unusable. The effective composition raw material 22a adhering to the surface of the holding member 21 is a film-like film positioned on the front side and the back side of the holding member/effective composition raw material/peeling protective member laminate with the peeling protective member 23 interposed therebetween. While sandwiched between the packaging containers, the holding member 21 and the effective composition raw material 22a are pressurized against each other, whereby a part of the effective composition raw material 22a enters the inside of the fine irregularities on the surface of the holding member 21. In this state, the effect composition raw material 22a is crosslinked and aged to be changed into the softening effect composition 22 in a soft state without fluidity, and in this way, the softening effect composition 22 in a soft state is obtained. It is possible to obtain the effect of forming a patch configured by bonding without peeling from the holding member 21 .
The holding member, the raw material for the efficacy composition, and the peeling member laminate are subjected to pressure difference between the inside and outside of the packaging container without passing through pressure means such as pressure by two rolls or pressure by a flat pressurizing press. As a result, part of the beneficial composition raw material 22a adheres to the holding member 21 in a state of entering into the unevenness of the finely uneven surface, and the flexible beneficial composition 22 in a soft state without fluidity is formed on the retaining member 21. It is possible to manufacture a patch that is bonded without peeling off from the adhesive.

The reduced pressure state lower than the atmospheric pressure is not particularly limited, but a reduced pressure state in which the packaging container can be deformed by the pressure due to the difference between the inside of the packaging container and the atmospheric pressure is desirable, for example, about 5 mmHg to about 700 mmHg. is desirable. Particularly preferably, the reduced pressure state is in the range of about 20 mmHg to about 600 mmHg. Note that the atmospheric pressure is approximately 760 mmHg.
In the case of a vacuum higher than about 5 mmHg, a long vacuum suction operation is required to reduce the pressure, so productivity tends to be inferior, and the components contained in the softening composition are vaporized. There is a concern that the contained components may deteriorate due to evaporation or the like. In the case of about 700 mmHg to about 760 mmHg, since the difference from the atmospheric pressure is small, the state in which the packaging container closely contacts and deforms along the shape of the holding member/effective composition raw material/peeling protective member laminate is reduced. , there is a tendency that it becomes impossible to obtain a patch storage package that is in a deformed state in close contact with the shape of the patch.

The holding member/effective composition raw material/peeling member laminate is placed in a packaging container, and the opening of the packaging container is sealed while the inside of the packaging container is in a reduced pressure state lower than the atmospheric pressure. The laminate packaging process for preparing a laminate containing package in which the inside of the packaging container is formed in a reduced pressure state lower than the atmospheric pressure is not particularly limited, but for example, the following method can be implemented.
・Reduced-pressure sealing method a: As shown in FIG. 6(A), a packaging container serving as a packaging container is placed at both the upper and lower positions of the holding member/effective composition raw material/releasing member laminate. In a state where the sheet for packaging is positioned, the laminate is positioned between the sheets for packaging containers and in a reduced pressure atmosphere, and the opening of the sheet for packaging containers is sealed to seal the packaging container sealing part A method of forming 3a and then returning the sealed bag-like packaging container to the atmosphere. As a result, it is possible to easily manufacture a laminated product containing package product in which the packaging container is easily deformed into a state of closely contacting along the shape of the holding member/effective composition raw material/peeling protective member laminate.
・Reduced pressure sealing method b: As shown in FIG. The opening of the bag-shaped packaging container is sealed to form a packaging container sealing portion 3a with only the inside of the bag-shaped packaging container being decompressed, and then the sealed bag-shaped packaging container is closed. How to return to atmosphere. As a result, it is possible to easily manufacture a laminated product containing package product in which the packaging container is easily deformed into a state of closely contacting along the shape of the holding member/effective composition raw material/peeling protective member laminate.
・Reduced pressure sealing method c: As shown in FIG. While the bag-like packaging container containing the laminate is placed in a reduced pressure atmosphere, the opening of the bag-like packaging container is sealed to form the packaging container sealing portion 3a, and then the sealed bag-like shape is formed. A method of returning a packaging container to atmospheric conditions. As a result, it is possible to easily manufacture a laminated product containing package product in which the packaging container is easily deformed into a state of closely contacting along the shape of the holding member/effective composition raw material/peeling protective member laminate.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
The packaging container is a heat-shrinkable packaging container having a property of shrinking when heated, and in the step (C), the holding member/effective composition raw material/peeling protective member laminate is heat-shrinkable. The heat-shrinkable packaging container 3c is thermally shrunk by heating while positioned in the shrinkable packaging container 3c, and the opening of the packaging container is sealed to prepare a laminate containing package. product packaging step, whereby the heat-shrinkable packaging container 3c is brought into close contact along the shape of the holding member/effective composition raw material/peeling protective member laminate due to the heat shrinking action to accommodate the deformed laminate It is characterized in that a packaged product is obtained.

This configuration provides the following effects.
[Method effect: Heat shrink adhesion]:
In a state in which the holding member/effective composition raw material/peeling protective member laminate is placed in a heat-shrinkable heat-shrinkable packaging container, the heat-shrinkable packaging container is heat-shrunk by heating, and the heat-shrinkable packaging container is heat-shrunk. With a configuration including a laminate packaging step of preparing a laminate storage package by sealing the opening of the shrinkable packaging container, the heat-shrinkable packaging container is formed by the heat-shrinking action of the heat-shrinkable packaging container. It is possible to easily obtain a deformed laminate containing package in which the packaging container is easily shrunk and closely adhered along the shape of the holding member/effective composition raw material/peeling protective member laminate. As a result, it is possible to stably mass-produce patch containing packages in which the packaging container is in close contact along the shape of the patch.

In a state in which the holding member/effective composition raw material/peeling protective member laminate is placed in a heat-shrinkable packaging container, the packaging container is heat-shrunk by heating and the opening of the packaging container is closed. The laminate packaging process for preparing a laminate containing packaged product by sealing is not particularly limited, but for example, the following heat-shrink packaging (shrink packaging) method can be implemented.
・Heat-shrinkable sealed packaging method a: As shown in Fig. 6(C), a holding member, an effective composition raw material, and a peeling member are laminated in a bag-shaped heat-shrinkable packaging container 3, 3c having an opening. A method of heating the heat-shrinkable bag-like packaging container and sealing the openings of the bag-like heat-shrinkable packaging containers 3, 3c in a state in which an object is housed. As a result, the heat-shrinkable packaging containers 3 and 3c are easily brought into close contact with each other along the shape of the holding member/effective composition raw material/peeling protective member laminate, thereby facilitating the deformation of the laminate containing package. can be manufactured.
・Heat-shrinkable sealing packaging method b: As shown in Fig. 6A, a heat-retaining member, an effective composition raw material, and a peeling member laminate are placed at both the upper and lower positions to form a packaging container. With the shrinkable heat-shrinkable wrapping container sheet placed thereon, the laminate is positioned between the heat-shrinkable wrapping container sheets, heated, and the opening of the wrapping container sheet is sealed. Method. As a result, it is possible to easily produce a laminate containing package product in which the heat-shrinkable packaging container is easily deformed into a state of closely contacting along the shape of the holding member/effective composition raw material/peeling protective member laminate.
These heat shrink sealing packaging methods can be carried out using a commonly used shrink packaging machine. For example, heating methods such as infrared heating, far-infrared heating, and steam heating, mass-produced inorganic devices such as tunnel-type continuous heating and batch-type heating, and other methods can be used.
The material used for the heat-shrinkable packaging container is not particularly limited, but polyvinyl chloride, polyethylene, polypropylene, polystyrene, polyolefin, polyethylene terephthalate, and the like are used, for example.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
The packaging container is made of a material that melts and fuses when heated, and in the step (C), by heating the opening of the packaging container 3, the opening of the packaging container 3 melts and fuses. It is characterized by being joined and hermetically sealed.

This configuration provides the following effects.
[Method effect: thermal fusion bonding of opening]:
The packaging container is made of a material that melts and fuses when heated, and by heating the opening of the packaging container, the opening of the packaging container melts and fuses and joins and seals. With this configuration, it is possible to easily obtain a laminate-containing package product in which the packaging container is easily deformed into a state of closely contacting along the shape of the holding member/effective composition raw material/peeling protective member laminate. As a result, it is possible to stably mass-produce patch-accommodating packages in which the packaging container adheres along the shape of the patch.

In packaging containers to be sealed under reduced pressure, materials used for heat-sealable packaging containers are not particularly limited, but for example, at least a heat-sealable plastic film and a sheet having a desired function. Laminated films with similar materials can be used. A polyethylene film, a polypropylene film, or the like is used as the heat-sealable plastic film. Sheet materials having desired functions include polyethylene terephthalate (polyester) films, polyamide (nylon) films, papers, woven fabrics, non-woven fabrics, metal foils (e.g. aluminum foil), and metal-deposited films (e.g. aluminum-deposited polyester films). , and other general-purpose plastic films can be used. Sheets with desired functions include the ability to suppress air permeation, the ability to have bending toughness, the ability to prevent wrinkles, the ability to resist tearing, the desired tearability, the ability to print characters, and other functions. Any sheet material having the desired functionality can be used.
In addition, in this configuration, it is also possible to apply a configuration in which the opening of the packaging container is heated and pressed, thereby facilitating the bonding of the opening.

<Method for manufacturing a patch containing package containing a patch having a softening composition laminated on the surface of the holding member without protruding from the surface of the holding member>
In the manufacturing method of the adhesive patch containing package of the present invention, the following configuration can also be implemented.
In the step (B), the softening composition raw material and the peel protection member are laminated in such a state that the softening composition 22 is positioned on the surface region of the holding member 21 without protruding from the surface of the holding member 21 . In the step (C), the holding member/effective composition raw material/peeling protective member laminate is placed in a packaging container, and the peeling protective member covers the flexible efficacy composition and the holding member. The opening of the packaging container is sealed so that the packaging container deforms along the shape of the laminate and comes into close contact with the peripheral margin of the holding member.

This configuration provides the following effects.
[Method Effect A: The softening composition located on the surface area of the holding member without protruding]:
The aforementioned [Method Effect A: Adhesive storage of the adhesive patch] is obtained, and the softening composition 22 formed between the holding member 21 and the peeling protective member 23 is placed between the holding member 21 and the peeling protective member 23. The phenomenon of protruding from the end portion is remarkably suppressed, and the adhesive patch 2 can be obtained. The inconvenience of not being able to remove the adhesive patch 2 is also eliminated, and when the adhesive patch 2 is attached to the human skin, the softening composition protruding from the surface or side surface of the holding member 21 is sticky, which is caused by stickiness. It is possible to obtain an adhesive patch storage package that eliminates the user's discomfort in such a situation and that can be used comfortably.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method including the following steps can also be carried out.
In the step (B), the peel protection member is placed in a state in which the effective composition raw material is positioned inside the periphery of the surface of the holding member to form the holding member peripheral blank portion 21a. The effective composition raw material and the peel protective member are laminated in a state of being located on the surface side of the holding member peripheral blank portion.
In the step (C), the holding member/effective composition raw material/peeling protective member laminate is placed in a packaging container, and the peeling protective member covers the flexible efficacy composition and the holding member. The opening of the packaging container is sealed so that the packaging container deforms along the shape of the laminate and comes into close contact with the peripheral margin of the holding member.
For example, in the (B) process of FIG. 1, the (B) process of FIG. 2, and the (B) process of FIG. It is laminated on the surface of the holding member 21 while forming the peripheral blank portion 21a.

This configuration provides the following effects.
[Method effect co-a: Margin around holding member]:
In the method of manufacturing the patch containing package of the present invention, particularly in the "(B) step, the active composition raw material is positioned inside the periphery of the surface of the holding member to form a margin around the holding member. In the state where the peel protection member is located on the surface side of the effective composition raw material and the margin around the holding member, the effective composition raw material and the peel protective member are laminated to form the holding member, the effective composition raw material, and the peel protection. In a state in which the member laminate is positioned in the packaging container, the peeling protective member covers the softening composition and is in close contact with the margin of the holding member around the holding member, and the packaging container assumes the shape of the laminate. The opening of the packaging container is sealed so that it is deformed along and comes into close contact". The phenomenon that the softening composition 22 formed between 21 and the peeling protective member 23 protrudes from the edge between the holding member 21 and the peeling protective member 23 is remarkably suppressed, and a patch can be obtained. As a result, the sticking-out softening composition 22 adheres to the inner surface of the packaging container 3, and the inconvenience that the patch 2 cannot be easily removed from the packaging container 3 is also eliminated, and the patch 2 can be applied to the human skin. In such a case, the user's discomfort caused by the stickiness of the softening effect composition protruding from the surface or side of the holding member 21 is eliminated, and the patch storage package can be used comfortably. product is obtained.
Furthermore, when the patch 2 is applied to the skin of the human body, the user feels discomfort due to stickiness on the surface of the patch 2 caused by the protruding softening composition 22 not being supported by the holding member 21. It is also possible to obtain the effect of being able to manufacture the adhesive patch containing package 1 in which the amount of the patch is remarkably suppressed.

In the holding member peripheral blank portion 21a located inside the periphery of the surface of the holding member 21, the distance from the periphery of the holding member surface to the softening composition 22, that is, the width dimension of the holding member peripheral blank portion 21a is It is desirable that the distance and length dimensions are at least equal to or greater than the thickness dimension of the effective composition raw material 22 . For example, when the effective composition material 22 laminated on the holding member 21 has a thickness of 2 mm, the width of the holding member margin 21a is preferably about 2 mm or more. This suppresses the protrusion of the softening composition 22 . If the width dimension of the holding member peripheral blank portion 21a is smaller than the thickness dimension of the beneficial composition raw material 22, the effect of suppressing the protrusion of the softening beneficial composition 22 tends to decrease.

In the manufacturing method of the adhesive patch containing package of the present invention, a configuration including the following steps can also be implemented.
In the step (B), the raw material of the beneficial composition is positioned on the surface of the holding member without protruding from the surface of the holding member, and the end face of the raw material of the beneficial composition is positioned between the holding member and the peeling member. The effective composition raw material is laminated on the surface of the holding member so as to be exposed, and the release member is laminated on the surface of the effective composition raw material.
In the step (C),
The holding member/effective composition raw material/peeling protective member laminate is placed in a packaging container, and the packaging container conforms to the shape of the holding member/effective composition raw material/peeling protective member laminate. The opening of the packaging container is sealed so that it is deformed by force and brought into close contact.

For example, as shown in FIG. 11, the emollient composition 22 has a flowable flow state at a first flow temperature and is not deformed at a second cooling non-deformation temperature that is lower than the first flow temperature. and has a soft state in which it is changed to a non-fluid form without fluidity at the third soft aging temperature, which is the second cooling non-deformation temperature, and the effect composition raw material 22a is The cooling non-deformation composition raw material 22a cooled to the second cooling non-deformation temperature has the following configuration.
(A) A fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material 22a having a flowable state at a first flow temperature, and a second cooling to bring the fluid efficacy composition raw material 22a into a non-deformed state. a cooled predetermined shape forming step of cooling to a non-deformed temperature to prepare a cooled non-deformed effective composition raw material 22b in a non-deformed state having a predetermined shape;
(B) The cooling non-deforming effect composition raw material 22b and the peeling protection member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peeling protection member 23 positioned on the surface side. A lamination member lamination step for preparing a benefit composition raw material/peel protective member laminate, wherein the cooled non-deformed beneficial composition raw material 22b is maintained in a non-deformed state, and the beneficial composition raw material is released from the surface of the holding member. The effective composition raw material is placed on the surface of the holding member so that it is positioned on the surface of the holding member without protruding and the end surface of the effective composition raw material is exposed from between the holding member and the peeling member. The cooled non-deformed benefit composition material 22b, which is laminated and laminates the release member to the surface of the benefit composition material, remains in an undeformed state.
(C) The holding member/effective composition raw material/release member laminate is placed in a packaging container, and the packaging container is formed into the shape of the holding member/effective composition raw material/release member laminate. a laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container 3 so as to deform along and adhere to the packaging container 3, wherein the cooled non-deformed effective composition raw material 22b remains undeformed.
(D) The cooled non-deformed composition raw material 22b is aged and changed into the softening composition 22 in a non-fluid state, and the softening composition 22 is adhered and joined to the holding member 21 to make it flexible. A maturing step of preparing a holding member/softening benefit composition/peeling protection member laminate in which the benefit composition 22 is adhered and bonded to the holding member 21, thereby turning the benefit composition raw material into the softening benefit composition 22 having no fluidity. A patch containing package 1 in which a patch 2 having a holding member, a softening composition and a peeling protection member having a configuration that has been aged and changed is formed, and the patch 2 is stored in the packaging container 3. is obtained.
For example, as an example, in FIG. 8, the ingredient of the benefit composition is cooled to about −3° C. in step (A), maintained in the cooled state in steps (B) and (C), and (D ) step, the temperature is raised to a room temperature of about 10° C. to about 30° C. or to about 30° C. to about 60° C., and in the process of raising the temperature and/or at the raised temperature, the ingredients of the efficacy composition contain water. It is possible to implement a process that results in a gel-like softening benefit composition that has matured composition.

This configuration provides the following effects.
[Method Effect C-b: End face close contact packaging of softening composition]:
With this configuration, the above-mentioned [Method Effect A: Adhesive storage of the patch] is obtained, and the softening composition 22 formed between the holding member 21 and the peeling protective member 23 is formed between the holding member and the peeling protective member. A patch 2 in which the phenomenon of protruding from the edge of the gap is remarkably suppressed can be obtained. Furthermore, when the adhesive patch 2 is applied to the human skin, the softening composition protruding from the surface or side of the holding member 21 is sticky. In addition, it is possible to obtain an adhesive patch storage package that can be used comfortably without the user's discomfort in the attached state.

In the above configuration, the fluid efficacy composition raw material 22a and the peeling member 23 are laminated on the surface of the holding member 21, and then the laminate of the holding member 21, the fluid efficacy composition raw material 22a, and the peeling member 23 is packaged. The packaging container is sealed along the shape of the laminate, and in the sealed state, the fluid efficacy composition raw material 22a is stored in a non-fluid flexible efficacy composition. Configurations having a step of aging and changing the morphology are also possible. With this configuration, the same effect as the aforementioned [Method Effect A: Close contact packaging of softening composition] can be obtained.

<Regarding patch storage packages containing patches>
A patch-containing package 1 of the present invention includes a patch 2 and a packaging container 3 containing the patch 2. The patch 2 includes a sheet-like holding member 21 and the holding member 21. A softening composition 22 having flexibility laminated by adhering to a predetermined position area on the surface, and a sheet-like peeling protection layer peelably laminated on the surface of the softening composition 22 during use. The softening composition 22 has adhesiveness, and when used, the patch 2 is removed from the packaging container 3, and the peel protection member 21 is peeled off from the removed patch 2. A patch storage package used by applying the softening composition 22 laminated and bonded to the holding member 23 to the skin of a human body, wherein the packaging container 3 contains the patch 2 and the patch 2 is positioned in the packaging container 3 and the packaging container 3 adheres along the shape of the patch 2. The patch 2 has a configuration in which the patch 2 is housed in the packaging container 3 and sealed, and the patch 2 is positioned in the packaging container 3 and the packaging container is the patch. The softening composition 22 has stickiness and has a matured form in which the softening composition 22 is matured in the form of the softening composition 22 that is in a flexible state in a state of adhering along the shape of the agent 2. It is characterized by

This configuration provides the following effects.
[Constructive effect A: patch storage package]:
In the patch containing package of the present invention, the softening efficacy composition has a softened state in a state in which the patch is positioned in a packaging container and the packaging container is in close contact with the shape of the patch. Due to the composition having a composition having a matured form, the content of the ingredients contained in the softening composition is reduced due to the deterioration or deterioration of the ingredients due to evaporation or chemical reaction with the air. It is possible to obtain an effect of obtaining an adhesive patch storage package having stable quality by suppressing changes in the content composition and chemical deterioration.
Furthermore, in order to provide a configuration in which the shape of the fluid efficacy composition raw material is maintained during aging, the space between the holding member for the fluid efficacy composition raw material and the peel protection member sandwiched between the holding member and the peel protection member. is prevented from escaping from the As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated. Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.

<Regarding patch storage packages with a packaging container that adheres to the shape of the patch>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
In a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch, the flexible efficacy composition is in the form of a fluid efficacy composition raw material in a fluid state. Therefore, it is characterized by having a composition having a matured form obtained by aging in the form of a softening effect composition having a soft state without fluidity.

This configuration provides the following effects.
[Structural effect B: patch storage package]:
The above-described (structural effect a) can be obtained, and the flexible composition 22 laminated on the holding member 21 can be formed with high accuracy in desired thickness, area, shape, weight, lamination position, etc., and Thus, a patch containing package 1 having a desired quality can be obtained stably without fluctuations in the composition component ratios contained during aging or the like. Furthermore, the flow benefit composition raw material 21a sandwiched between the holding member 21 and the peeling protective member 23 is prevented from protruding from between the holding member 21 and the peeling protective member 23. FIG. As a result, the inconvenience of not being able to easily remove the adhesive patch 2 from the packaging container 3 caused by the protruded softening composition 22 adhering to the inner surface of the packaging container 3 is eliminated. Furthermore, when the patch 2 is applied to the skin of the human body, the softening composition 22 protruding out is not supported by the holding member 21 and the surface of the patch 2 is tacky. It is possible to obtain an adhesive patch storage package that eliminates the pleasant feeling and can be used comfortably.

<Regarding a patch storage package containing a patch provided with a softening effect composition obtained by aging from a cooling non-deforming effect composition raw material>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The softening composition 22 has the form of a fluid composition raw material 22a having a flowable state at the first fluidizing temperature, and is not deformed at a second cooling non-deformation temperature lower than the first fluidizing temperature. and has the form of the cooling non-deforming effect composition raw material 22b having a non-deformed state of , and is changed to a non-fluid form without fluidity at the third soft aging temperature raised from the second cooling non-deformed temperature. The patch is positioned in the packaging container and the packaging container conforms to the shape of the patch. In a state of close contact, the softening composition transforms from a form having a non-deformed state at the second cooling non-deforming temperature to a non-fluid form having no fluidity at the third softening aging temperature. It is characterized by comprising a composition having a matured form that has been aged in the form of a softening effect composition.

This configuration provides the following effects.
[Constructive effect C: Cooling non-deforming effect composition raw material]:
The aforementioned [Constructive effect A: Adhesive storage of the patch] is obtained, and the beneficial composition 22 sandwiched between the holding member 21 and the peeling protective member 23 does not protrude from between the holding member 21 and the peeling protective member 23. is prevented. As a result, the inconvenience of not being able to easily remove the patch 2 from the packaging container due to the protruded softening composition 22 adhering to the inner surface of the packaging container 3 is eliminated, and the patch storage package 1 is obtained. . Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the protruding softening composition not being supported by the holding member 21. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably. In addition, it is possible to stably and accurately mass-produce patches with the desired performance without changing the ratio of the ingredients due to the evaporation of the ingredients during aging, and as a result, the yield of non-defective products can be significantly improved. Thus, it is possible to stably mass-produce patch containing packages 1 having desired quality, and to obtain the patch containing packages 1 that enable significant cost reduction.

<Regarding a patch storage package containing a patch provided with a softening composition obtained by aging from a raw material of a cut-cooled non-deformable composition>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The softening effect composition has the form of a flow benefit composition raw material 22a having a flowable state at the first flow temperature, and is deformed before and after cutting at a second cooling non-deformation temperature lower than the first flow temperature. It has a non-deformed state to the extent that it is not deformed and has the shape of the cut and cooled non-deformed effect composition raw material 22c that has been cut, and has a non-fluid form without fluidity at the third soft aging temperature that is raised from the second cooling non-deformed temperature. It has the property of having a matured form that has been aged in the form of a softening effect composition 22 that has a softening state that has been changed to .
In a state in which the patch 2 is positioned in the packaging container 3 and the packaging container 3 is in close contact along the shape of the patch 2, the softening composition 22 is applied to the second cooling non-deformation It has a matured form that has been aged into the form of the softening effect composition 22 that has a soft state that is changed from a form having a non-deformed state at the third soft aging temperature to a non-flowable form without fluidity at the third soft aging temperature.
The patch 2 has the holding member 21 and a predetermined shape cut at the second cooling non-deformation temperature, which has a non-deformed state to the extent that it does not deform at the time of cutting, and the holding member 21 at the third soft aging temperature. a softening composition 22 arranged and bonded to a predetermined position area on the surface of the holding member 21; Be prepared.

This configuration provides the following effects.
[Structural effect D: raw material for cutting/cooling non-deforming effect composition]:
In addition to obtaining the aforementioned [Constructive Effect A: Adhesive storage of the patch] and [Constructive Effect C], the cut cooling non-deformable efficacy composition raw material 22c cut into a predetermined shape has an accurate desired plane shape and thickness shape. and is stored in close contact with the packaging container 3, a patch containing package having a desired shape can be obtained.
In addition, since the softening composition is cut into a desired shape and maintains its shape, the softening composition laminated on the holding member has a desired thickness, area, shape, weight, lamination position, etc. can be formed with high accuracy. In addition, since the softening effect composition 22 aged in the packaging container 3 is composed, the composition component ratio of the aged softening effect composition 22 does not fluctuate and the composition component ratio of the softening agent is stabilized. A patch-containing package 1 containing the efficacy composition 22 is obtained. In this way, the yield of non-defective products is remarkably improved, patches of desired quality can be stably mass-produced, and patch-containing packages at reduced cost can be obtained.

<Regarding vacuum-sealed patches containing packages>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The patch 2 is housed in the packaging container 3 and sealed in a state in which the patch 2 is positioned in the packaging container 3 and the packaging container 3 is in close contact along the shape of the patch 2 . The patch 2 is placed in the packaging container 3 and the inside of the packaging container 3 is in a reduced pressure state lower than the atmospheric pressure, and the patch 2 is placed in the packaging container 3. It is characterized by being housed and sealed.

This configuration provides the following effects.
[Construction effect: decompression adhesion]:
The patch 2 is placed in the packaging container 3 and the pressure inside the packaging container 3 is reduced below atmospheric pressure, and the patch 2 is stored and sealed in the packaging container 3. and the packaging container 3 is in close contact with the shape of the patch 2, thereby obtaining the aforementioned [Constructive Effect A: Adhesive storage of the patch], and at the same time, It is possible to obtain a product in which the patch storage package 1 in which the container 3 is in close contact with the shape of the patch 2 is stably mass-produced. In addition, the softening composition 22 sandwiched between the holding member 21 and the peeling protective member 23 is prevented from squeezing out from between the holding member 21 and the peeling protective member 23 . As a result, the inconvenience of not being able to easily remove the patch 2 from the packaging container 3 due to the protruded softening composition sticking to the inner surface of the packaging container 2 is eliminated, and the patch storage package 1 is completed. can get. Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.
In particular, in a patch composed of a porous material having a finely uneven surface as the holding member 21, due to the pressure difference between the inside and outside of the packaging container, the adhesive sticks to the surface of the holding member 21. The effective composition raw material 22 is sandwiched between the film-like packaging containers located on the front side and the back side of the holding member/effective composition raw material/peeling protective member laminate via the peeling protective member 23. , the holding member 21 and the beneficial composition raw material 22 are pressurized against each other, whereby a part of the softening beneficial composition 22 adheres to the inside of the fine irregularities on the surface of the holding member 21 and is aged. Therefore, it is possible to obtain an effect that a patch is obtained in which the softening composition 22 in a soft state without fluidity is adhered to the holding member 21 without being peeled off.

<Regarding patch storage packages sealed in a heat-shrinkable packaging container>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The patch 2 is housed in the packaging container 3 and sealed in a state in which the patch 2 is positioned in the packaging container 3 and the packaging container 3 is in close contact along the shape of the patch 2 . The packaging container 3 is a heat-shrinkable packaging container 3 having a property of shrinking when heated, and the adhesive patch 2 is positioned in the heat-shrinkable packaging container 3, and the A heat-shrinkable packaging container 3 is thermally shrunk by heating, and the patch 2 is housed in the packaging container 3 and sealed.

This configuration provides the following effects.
[Structural effect: heat shrink adhesion]:
The packaging container 3 is a heat-shrinkable packaging container 3 having a property of shrinking when heated. With the patch 2 positioned in the heat-shrinkable packaging container, the heat-shrinkable packaging container 3 shrinks when heated. The configuration in which the patch 2 is housed in the packaging container 3 in a shrunk state and hermetically sealed provides the aforementioned [Structural Effect A: Adhesive storage of the patch].
It is possible to stably mass-produce the patch containing package 1 in which the packaging container 3 adheres along the shape of the patch 2 . In addition, the softening composition 22 sandwiched between the holding member 21 and the peeling protective member 23 is prevented from oozing out from between the holding member 21 and the peeling protective member 23 . As a result, the inconvenience of not being able to easily take out the patch 2 from the packaging container 3 due to sticking of the protruded softening composition to the inner surface of the packaging container 3 is eliminated, and a patch storage package is obtained. Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.

[Structural effect: Heat-sealed opening]:
The configuration in which the opening of the packaging container is joined and sealed by melting and fusing makes it possible to easily obtain a laminate containing packaged product that is closely adhered along the shape of the patch, In addition, it is possible to obtain a patch-containing package that can keep the packaging container in close contact with the shape of the patch over a long period of time by suppressing the intrusion of air into the inside of the package.

<Regarding softening composition containing water and water-soluble polymer>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The softening composition 22 contains at least water and a water-soluble polymer, has a flowable state at a first flow temperature, and deforms at a second cooling non-deformation temperature lower than the first flow temperature. The water-containing gel-like softening effect composition 22 has a non-deformed state to the extent that it does not deform, has a non-fluid flexible state at a third soft aging temperature obtained by raising the second cooling non-deformed temperature, and has adhesiveness. , is characterized by
As the water-soluble polymer, a configuration containing the above-described crosslinkable water-soluble polymer and/or non-crosslinkable water-soluble polymer can be implemented.

This configuration provides the following effects.
[Structural effect S: Water-soluble polymer/water-containing gel-like softening effect composition]:
The softening composition 22 contains at least water and a water-soluble polymer, has a flowable state at a first flow temperature, and does not deform at a second cooling non-deformation temperature lower than the first flow temperature. The water-containing gel-like softening composition 22 has a degree of non-deformation, and has a non-fluid, flexible state at the third soft aging temperature obtained by raising the second cooling non-deformation temperature, and has adhesiveness. As a result, the aforementioned [Constructive effect A: Adhesive storage of the patch] can be obtained, and furthermore, the gel component of the water-containing gel-like softening composition 22 can be freely designed, and the patch 2 can be applied to the human body. In some cases, a pleasant cooling sensation due to water can be obtained, and the water-containing gel-like softening composition 22 is harmless to the human skin, so that a skin-friendly patch can be obtained.
Furthermore, the phenomenon that the water-containing gel-like softening composition 22 formed between the holding member 21 and the peeling protective member 23 protrudes from the edge between the holding member 21 and the peeling protective member 23 is remarkably suppressed, so that the adhesive patch can be removed. As a result, the inconvenience of not being able to easily remove the patch from the packaging container caused by the protruding water-containing gel-like softening composition sticking to the inner surface of the packaging container is also eliminated. Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.
Furthermore, the adhesive patch 2 having the desired performance can be stably mass-produced with high precision without fluctuations in the ratio of the contained component caused by the evaporation of water, which is the contained component, during aging. can be remarkably improved, patches of desired quality can be stably mass-produced, and a patch containing package 1 can be obtained that makes it possible to significantly reduce costs.
A crosslinked hydrogel softening composition is desirably used as the hydrogel softening composition.

In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The softening composition 22 contains at least water, a water-soluble polymer, and a cross-linking agent capable of chemically cross-linking the water-soluble polymer, and has a flowable fluid state at the first fluid temperature, It has a non-deformed state at a second non-deformable cooling temperature that is lower than the first flow temperature, and a flexible state without fluidity at a third soft aging temperature that is the second non-deformable cooling temperature. and adhesiveness, wherein the water-soluble polymer comprises at least polyacrylic acid, neutralized polyacrylic acid, partially neutralized polyacrylic acid, and methacrylic acrylate. It is characterized by being at least one crosslinkable water-soluble polymer selected from the group consisting of acid copolymers, carboxyalkylcelluloses, hydroxyalkylcelluloses, carboxyvinyl polymers, and salts thereof.

In the configuration in which the softening composition 22 contains a crosslinkable water-soluble polymer and a cross-linking agent, for example, the first flow temperature is around room temperature of about 25°C, and the third softening aging temperature is around room temperature of about 25°C. Around 25° C. of the third soft aging temperature, the contained water-soluble polymer is crosslinked into a three-dimensional chemical structure to form a water-containing gel that has a flexible state without fluidity and has adhesiveness. It has a configuration that changes as it matures into the softening composition 22, and comprises a patch and a packaging container containing the patch, wherein the patch comprises a sheet-like holding member and the holding member. A softening composition having flexibility, which is laminated by adhering to a predetermined position area on the surface, and a sheet-like peeling protective member which is peelably laminated on the surface of the softening composition during use. In addition, the softening composition has adhesiveness, and at the time of use, the patch is taken out from the packaging container, and the peel protection member is peeled from the taken out patch and laminated on the holding member. It is possible to implement an adhesive patch storage package, which is used by applying the softening effect composition bonded to the skin of a human body, and has the following configuration.
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch, and the patch comprises an effective composition raw material having fluidity at a first flow temperature of about 25° C., which is normal temperature. is positioned in the packaging container and the packaging container is in close contact along the shape of the patch, and the patch is housed in the packaging container and sealed. Then, at about 25° C. of the third soft aging temperature, the patch containing the active composition raw material having flowability is positioned in the packaging container, and the packaging container takes the shape of the patch. The ingredients of the active composition are chemically cross-linked and changed from a fluid form with fluidity to a non-fluid form with no fluidity in the form of a flexible efficacy composition having a flexible state. It has a matured form.

Moreover, as another configuration, the following configuration can also be implemented.
For example, the first flow temperature is around room temperature of about 25°C, the second cooling non-deformation temperature is a cooled temperature of about 3°C or less, and the third soft aging temperature is around room temperature of about 25°C. At about 25° C., which is the third soft aging temperature, the water-soluble polymer contained is crosslinked into a three-dimensional chemical structure, resulting in a water-containing gel-like softening composition that has a soft state without fluidity and has adhesiveness. A configuration that changes as it matures into a substance 22, and includes a patch and a packaging container containing the patch, wherein the patch is a sheet-like holding member and a predetermined portion on the surface of the holding member. and a sheet-like peeling protective member laminated on the surface of the softening composition so as to be peelable during use, The softening composition has adhesiveness, and when used, the patch is removed from the packaging container, the peel protection member is peeled off from the removed patch, and the adhesive is laminated and bonded to the holding member. A patch storage package for use by applying the softening composition obtained above to the skin of a human body, wherein the packaging container has flexibility to the extent that it can be deformed along the shape of the patch. , the first flow temperature is about 25°C, which is normal temperature, and the cooling non-deformation composition raw material having a predetermined shape is cooled to about -2°C as the second cooling non-deformation temperature. The holding member/effective composition raw material/peeling protective member laminate provided is positioned in the packaging container and the packaging container is in close contact along the shape of the patch, and the holding member/effective composition The adhesive/peeling protective member laminate has a form in which it is housed and sealed in the packaging container, and at about 25° C., the third soft aging temperature, the patch comprising the ingredients of the efficacy composition is formed. In a state where the packaging container is positioned in the packaging container and the packaging container is in close contact along the shape of the patch, the functional composition raw material is chemically crosslinked to change from a fluid form having fluidity to fluidity. It has a matured form that is aged in the form of a softening effect composition that has a softening state that is changed to a non-flowing form without any moisture.

The configuration containing the above-described crosslinkable water-soluble polymer has the above-described [Constructive effect A] and also provides the following effects [Constructive effect C-a] and [Constructive effect C-b].
[Structure effect C-a: Crosslinkable water-soluble polymer, water-containing gel-like softening composition, room temperature aging]:
In this configuration, the above-mentioned [Constructive effect S] is obtained, and by designing and containing both types of the crosslinkable water-soluble polymer and the crosslinker as desired, crosslinkage and maturation can be achieved at the desired temperature. It is possible to obtain a water-containing gel-like softening composition. For example, it is possible to obtain a crosslinked water-containing gel-like softening composition at a temperature of about 30°C or less without having to raise the temperature to a temperature above about 30°C. That is, in step (A), there is a "fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a flowable state in an atmosphere of room temperature of about 10°C to about 30°C", and (D ) in the step “Aging and changing the efficacy composition raw material constituting the laminate storage package into a flexible efficacy composition in a flexible state without fluidity in an atmosphere of about 10° C. to about 30° C. of room temperature. and a maturing step of adhering and bonding the softening composition to the holding member to prepare a holding member/softening composition/peeling protective member laminate in which the softening composition is adhered and joined to the holding member, whereby the efficacy A patch comprising a holding member, a softening composition, and a peeling protection member having a configuration changed by aging a composition raw material into a softening composition having a flexible state without fluidity is formed, and the patch is formed. A patch-containing package stored in the packaging container is obtained." can be implemented. In other words, in both the (A) process and the (D) process, it is possible to carry out the manufacturing in an atmosphere of about 10° C. to about 30° C. of room temperature.
In addition, with this configuration, it is possible to obtain the effect of suppressing evaporation of water due to temperature rise, preventing fluctuations in the contained composition, and suppressing thermal deterioration of the contained components due to temperature rise.
Furthermore, the gel component and medicinal components of the hydrous gel composition can be freely designed, and when the patch is applied to the human body, the patch exhibits a moderate cooling sensation due to the hydrous component and a medicinal effect due to the medicinal component. In addition, a patch which can minimize skin irritation and which is gentle on the skin is obtained.
Further, in the state of being housed in the packaging container, the ingredients of the efficacy composition are crosslinked to form a three-dimensional network chemical structure, and the matured water-containing gel-like softening efficacy composition having a gel-like soft state without fluidity. Therefore, it is possible to remarkably suppress changes in the content composition of the efficacy composition due to evaporation of moisture, etc. during aging, and to stably produce a patch having desired adhesiveness and flexibility. Become.
Furthermore, by selecting the type of cross-linking agent, it becomes possible to cross-link at around room temperature, so that the softness effect composition is cross-linked by cross-linking the effect composition raw materials in the state of being housed in the packaging container. can be produced, and the production time can be significantly reduced compared to the case where the crosslinked patch is stored in a packaging container.
In addition, the cost of electric power required for heating and raising the temperature is also reduced, resulting in the effect of being able to manufacture at low cost.
In addition, by selecting and containing the desired type of cross-linking agent, the cross-linking rate is remarkably slow at about 30° C. or lower, and the cross-linking is promoted in the temperature range of about 30° C. to 60° C., resulting in a production process in a short time. is also feasible. By this method, since the fluidity of the fluid efficacy composition raw material is maintained for a long time, the time from the preparation of the fluid efficacy composition raw material in step (A) to the laminate packaging step in step (C) can be adjusted as desired. A designable manufacturing method is obtained.

[Structure effect C-b: Crosslinkable water-soluble polymer, water-containing gel-like softening composition, suppression of protrusion]:
By the manufacturing method in which the water-containing gel-like softening composition containing the crosslinkable water-soluble polymer and the crosslinker is formed, the above-mentioned [Constructive effect S] is obtained, and furthermore, the holding member 21 and the peel protection member The phenomenon that the water-containing gel-like softening composition 22 formed between the holding member 21 and the peeling protection member 23 protrudes from the edge between the holding member 21 and the peeling protective member 23 is remarkably suppressed, and a patch can be obtained. The inconvenience that the patch 2 cannot be easily removed from the packaging container 3 due to the protruding softening composition 22 sticking to the inner surface of the packaging container 3 is also eliminated, and the patch 2 can be applied to the human skin. The patch significantly suppresses the user's discomfort due to stickiness on the surface of the patch 2 caused by the protruding water-containing gel-like softening composition 22 not being supported by the holding member 21. The effect of being able to manufacture the storage package 1 can be obtained.

<Regarding the configuration provided with the softening composition containing a water-soluble polymer and not containing a cross-linking agent>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
As the softening composition, it is also possible to implement a configuration comprising a softening composition that contains a crosslinkable water-soluble polymer and/or a non-crosslinkable water-soluble polymer and does not contain a cross-linking agent.
As the water-soluble polymer, the aforementioned crosslinkable polymer and/or non-crosslinkable water-soluble polymer can be used.
[Constructive Effect C-c: Water-soluble polymer/water-containing gel-like softening composition containing no cross-linking agent]:
In the structure provided with the softening effect composition containing the water-soluble polymer and not containing the cross-linking agent, an effect similar to that of the above-mentioned [Structure effect S: water-soluble polymer/water-containing gel-like softening effect composition] can be obtained.

A package containing a patch containing a cooled water-containing gel-like softening effect composition obtained by aging from a cooling non-deformation effect composition raw material containing a water-soluble polymer cooled to a second cooling non-deformation temperature. has the following effects.
[Structural effect: water-soluble polymer, water-containing gel-like softening composition, cooling]:
The above-mentioned [structural effect A], [structural effect C-a], and [method effect C-b] are obtained, and in particular, the aforementioned [structural effect C: cooling non-deformation effective composition raw material] is remarkably exhibited. .

A patch containing a patch comprising a cooled water-containing gel-like softening effect composition aged from a cut cooling non-deformation effect composition raw material containing a water-soluble polymer that is cooled to a second cooling non-deformation temperature and cut. The agent containing package has the following effects.
[Structural effect: water-soluble polymer/cut cooling water-containing gel-like effect composition]:
The patch 2 has a holding member 21 and a predetermined shape cut at the second cooling non-deformation temperature, which has a non-deformed state to the extent that it is not deformed during cutting, and the surface of the holding member at the third soft aging temperature. A softening composition 22 arranged and bonded to a predetermined position area, and a peeling protection member 23 placed to cover the surface of the softening composition 22 bonded to the surface of the holding member 21. According to the configuration, the above-mentioned [structural effect A: adhesive patch storage], [structural effect C] and [structural effect D] can be obtained, and the cut water-containing gel-like flexible efficacy composition cut into a predetermined shape can be accurately obtained. Since it has a desired planar shape and thickness and is housed in a packaging container in close contact, a patch containing package having a desired shape can be obtained.
In addition, since the cut water-containing gel-like softening composition is cut into a desired shape, the cut water-containing gel-like softening composition laminated on the holding member has a desired thickness, area, shape, It can be formed with high precision in terms of weight, stacking position, and the like. In addition, since the cut gel-like softening effect composition is aged in the state housed in the packaging container 3, the composition ratio of the aged cut gel-like softening effect composition is stable without fluctuation. A patch-containing product is obtained that constitutes a cut gel-like softening composition of the proportions of the components.
In addition, the water-containing gel-like softening effect composition material 22a is cooled and cut into the cooled non-deformed effect composition material 22b to form the cut and cooled non-deformed effect composition material 22c in a predetermined shape. In , the disadvantage that the water-containing gel-like beneficial composition raw material adheres to the blade used for cutting is suppressed, and the occurrence of defects during mass production is also suppressed, thereby significantly improving productivity.
In this way, the yield of non-defective products is remarkably improved, patches having desired quality can be stably mass-produced, and patch-containing products at reduced cost can be obtained.
As the cut water-containing gel-like softening effect composition, a cross-linked cut water-containing gel-like softening effect composition is desirably implemented.

<Regarding the patch storage package product containing the patch with multiple types of emollient compositions>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The softening effect composition 22 has a plurality of types of softening effect compositions containing composition components different from each other, and the respective softening effect compositions 22 of the plurality of types of softening effect compositions have at least stickiness and The patch 2 has different effects, and includes a sheet-shaped holding member 21, a plurality of types of emollient compositions 22 arranged and bonded to predetermined positions on the surface of the holding member 21, and the emollient effect. a sheet-shaped peeling protective member 23 laminated to cover the surface of the composition 22, and (i) each of the plurality of types of softening compositions 22 has a predetermined shape, (ii) each of the plurality of types of softening compositions 22 is arranged adjacent to each other on a planar region of the surface of the holding member 21 and joined to each other; It has a predetermined shape and is arranged in a predetermined region on the surface of the holding member 21 so as to overlap each other and is joined to each other. In a state in which the packaging container 3 is in close contact with the shape of the patch 2, the plurality of types of the softening composition 22 has a matured form of the softening composition 22 in a flexible state. It is characterized by comprising the following configuration.

This configuration provides the following effects.
[Constituent effect: multiple types of softening effect composition]:
In addition to obtaining the above-mentioned [Constructive Effect A: Adhesive storage of patch], multiple types of softening effect compositions 22 with different compositional components are formed with high precision in desired thickness, area, shape, weight, lamination position, etc. In addition, mass production can be stably performed without changing the ratio of the compositional components contained.
Furthermore, in order to maintain the shape of the plurality of types of softening composition during aging, the holding member and the peeling protection member for the plurality of types of softening composition sandwiched between the holding member 21 and the peeling protection member 23 are provided. Protrusion from between is prevented. As a result, the inconvenience of not being able to easily remove the adhesive patch 2 from the packaging container 3 due to the protruded softening composition adhering to the inner surface of the packaging container is eliminated.
Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.

[Constituent effect car-a: multiple types of softening effect composition/plane]:
In addition to the above [constituent effect: multiple types of softening compositions], a softening composition 22 having regions of different compositional components placed adjacent to each other on the surface region of one holding member 21. can be easily formed, and as a result, the patch containing package 1 having desired quality can be stably obtained. For example, a patch area with a cooling effect, a softening composition area with analgesic effect, a softening composition area with strong adhesiveness, etc. are alternately formed in the planar direction of the surface area of the holding member 21 . As a result, it is possible to obtain the patch containing package 1 including the patch 2 exhibiting desired effects such as excellent cooling effect and/or analgesic and anti-inflammatory effect and having excellent adhesive performance.

[Constituent effect car-b: multiple types of softening composition/laminate]:
In addition to the above [constituent effect: multiple types of softening compositions], it is possible to easily form softening compositions having different compositional components that overlap each other in the stacking direction on the surface of the holding member. As a result, patches 2 having desired quality can be stably mass-produced. For example, in a softening composition containing multiple types of active ingredients with different solubility and compatibility, a desired effect can be achieved by arranging multiple types of softening composition optimal for each active ingredient in the stacking direction. The patch containing package 1 is easily obtained.

<Regarding the patch storage package containing the patch provided with the softening composition laminated on the surface of the holding member without protruding from the surface of the holding member 21>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
In the patch 2, the softening composition 22 is laminated on the surface of the holding member 21 in such a state that the softening composition 22 is positioned on the surface region of the holding member 21 without protruding from the surface of the holding member 21. In addition, the peeling protective member 23 covers the surface of the softening composition 22, and the packaging container 3 is formed in a form in close contact with the surface of the peeling protective member 23. , wherein the packaging container 3 is configured in a state of being in close contact along the shape of the patch.

This configuration provides the following effects.
[Structural Effect Co: The softening composition located on the surface area of the holding member without protruding]:
The aforementioned [Constructive Effect A: Adhesive storage of the adhesive patch] is obtained, and the softening composition 22 formed between the holding member 21 and the peeling protective member 23 is arranged between the holding member 21 and the peeling protective member 23. The phenomenon of protruding from the end portion is remarkably suppressed, and the adhesive patch 2 can be obtained. The inconvenience of not being able to remove the adhesive patch 2 is also eliminated, and when the adhesive patch 2 is attached to the human skin, the softening composition protruding from the surface or side surface of the holding member 21 is sticky, which is caused by stickiness. It is possible to obtain an adhesive patch storage package that eliminates the user's discomfort in such a situation and that can be used comfortably.

In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
In the patch 2, the softening composition 22 is positioned inside the periphery of the surface of the holding member 21 to form a holding member peripheral blank portion 21a, and the softening composition 22 is applied to the holding member. 21, and the peel protection member 23 covers the softening composition 22 and is formed in close contact with the holding member peripheral margin 21a of the holding member. is configured in a state of being adhered along the shape of the patch 2 .

This configuration provides the following effects.
[Structural effect co-a: Margin around holding member]:
In the patch 2, the softening composition 22 is laminated on the surface of the holding member 21 in such a state that the softening composition 22 is positioned inside the periphery of the surface of the holding member 21 to form the holding member peripheral margin 21a. In addition, the peeling protective member 23 covers the softening composition 22 and is formed in close contact with the holding member peripheral margin 21 a of the holding member 21 , and the packaging container 3 follows the shape of the patch 2 . The above-mentioned [Construction Effect A] is obtained by the structure in which the holding member 21 and the peeling protection member 23 are in close contact with each other. The phenomenon of protruding from the edge between the adhesive layer and the peeling protective member 23 is remarkably suppressed, and the adhesive patch 2 can be obtained. The inconvenience of not being able to easily remove the agent from the packaging container is also eliminated, and furthermore, when the patch 2 is applied to the human skin, the softening composition protruding from the surface or side of the holding member 21 has stickiness. It is possible to obtain a patch containing package that can be used comfortably by eliminating the user's discomfort when the patch is applied.

The distance from the periphery of the holding member to the periphery of the softening composition 22 in the holding member peripheral margin 21a located inside the periphery of the surface of the holding member 21, that is, the width dimension of the holding member peripheral margin 21a is preferably at least equal to or greater than the thickness dimension of the softening composition 22. For example, when the thickness of the softening composition laminated on the holding member 21 is 2 mm, the width dimension of the holding member peripheral margin 21a is preferably about 2 mm or more. As a result, a patch in which the softening composition 22 is suppressed from sticking out is obtained. If the width dimension of the holding member marginal portion 21a is smaller than the thickness dimension of the softening composition 22, the effect of suppressing the softening composition from squeezing out tends to decrease.
This configuration is illustrated, for example, in (D) of FIG. 1, (D) of FIG. 2, and (D) of FIG.

In the adhesive patch storage package of the present invention, a manufacturing method having the following configuration can also be carried out.
The adhesive patch 2 is arranged such that the softening composition 22 is positioned on the surface region of the holding member 21 without protruding from the surface of the holding member 21 and the end surface of the softening composition is exposed. The substance 22 is laminated on the surface of the holding member 21, and the peeling protective member 23 covers the surface of the softening composition 22, and the packaging container 3 is covered with the peeling protective member 23. and the end surface of the softening composition, and the packaging container 3 is configured to adhere to the shape of the patch along the shape of the patch. do.

This configuration provides the following effects.
[Structural Effect Co-b: End face close contact packaging of softening composition]:
"A patch consists of a softening composition laminated on the surface of a holding member with the end surface of the softening composition exposed, a peel protection member covering the surface of the softening composition, and a packaging container. It is formed in a form in close contact with the surface of the peeling protective member and the end surface of the flexible composition, and the packaging container is configured in a state in which it is in close contact along the shape of the patch. In addition, the phenomenon that the softening composition 22 formed between the holding member 21 and the peeling protective member 23 protrudes from the edge between the holding member 21 and the peeling protective member 23 is remarkably suppressed. As a result, when the patch composing the protruding composition for softening is stored in a packaging container, the composition for softening that protrudes onto the inner surface of the packaging container. The inconvenience that the adhesive patch cannot be easily removed from the packaging container due to stickiness is eliminated, and the adhesive patch 2 protrudes from the surface or side of the holding member 21 when applied to the skin of the human body. The user's discomfort caused by the stickiness of the composition is eliminated, and a patch containing package that can be used comfortably can be obtained.

<Regarding the patch storage package containing the patch provided with the flexible efficacy composition containing the medicinal ingredient>
In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The emollient composition 22 contains water and/or a medicinal ingredient, and the protective member 23 of the adhesive patch 2 taken out from the packaging container 3 is peeled off from the emollient composition 22 to remove the holding member. When the softening composition 22 laminated and bonded to 21 is applied to the human skin and used, the cooling effect is caused by the water and/or the medicinal ingredients contained in the softening composition 22. and/or have a medicinal effect.

This configuration provides the following effects.
[Constituent effect: cooling effect/medicine effect]
The softening composition 22 may contain a component that has a cooling effect or a cooling effect and/or a medicinal component that has a medicinal effect. and/or an excellent cooling sensation or cooling sensation and/or a medicinal effect can be obtained when the patch containing the medicinal ingredient is applied to the skin of the human body.
A component that exhibits a cooling effect or a cooling sensation effect is not particularly limited, but water, menthol, etc. can be used, for example.
The medicinal ingredient that exerts a medicinal effect is not particularly limited. Medicinal ingredients that exhibit analgesic and anti-inflammatory effects, such as biprofen and terbinafine, can be used.

In the adhesive patch storage package of the present invention, a manufacturing method having the following configuration can also be carried out.
The softening effect composition 22 has a plurality of types of softening effect composition 22 having different compositional components, and the respective softening effect compositions 22 of the plurality of types of softening effect composition exhibit mutually different effects, and the plurality of types of softening effect composition (i) the second cooling non-deformation temperature having a non-deformed state to the extent that it is not deformed; each of the softening composition 22 having a predetermined shape at the third soft aging temperature and having a predetermined shape bonded to the planar area of the surface of the holding member 21 at the third soft aging temperature is applied to the planar area of the surface of the holding member 21 The plurality of types of softening compositions 22, which are arranged adjacent to each other and joined together, comprise at least a first softening composition containing a percutaneously absorbable active ingredient, and a human body. It is characterized by comprising a second softening composition that exhibits stronger adhesiveness than the first softening composition when applied to the skin.

This configuration provides the following effects.
[Constructive effect car-a: percutaneously absorbable medicinal ingredient and strong adhesiveness/flat surface]:
With this configuration, when the patch 2 stored in the patch storage package is applied to the skin of a human body, a patch storage package that exhibits desired transdermal absorption efficacy can be obtained. For example, in the configuration provided with a flexible composition containing an analgesic and antiphlogistic agent, a patch storage package having an analgesic and antiphlogistic efficacy as well as a strong adhesive strength can be obtained. Alternatively, in a configuration comprising a softening composition containing an analgesic and antiphlogistic agent and a softening composition containing menthol, a patch storage package having the above-mentioned analgesic and antiphlogistic efficacy and excellent cooling sensation can be obtained. .

Typical examples of the method for producing a patch and the patch of the present invention are described below.

(Exemplary Example 1: Preparation of raw materials for various fluid efficacy compositions)
(Typical Example 1-1)
Fluid efficacy composition raw material preparation step for preparing A1 fluid efficacy composition raw material 22a having a flowable fluid state:
A first melt is obtained by mixing polyacrylic acid, sodium polyacrylate, sodium carboxymethylcellulose and water in an atmosphere of room temperature of about 25°C. Separately, polyvinyl alcohol is added to water and dissolved to obtain a second dissolved product. These first melt, second melt, glycerin, paraben, menthol, tartaric acid, cross-linking agent and remaining water are added and well stirred and mixed. A cross-linking agent aqueous solution prepared separately is added to this and mixed.
Thus, 2 g of polyacrylic acid, 4 g of sodium polyacrylate, 3 g of polyvinyl alcohol, 18 g of glycerin, 1 g of carboxymethylcellulose sodium, about 0.1 g of menthol, about 0.1 g of parabens, a trace of tartaric acid, a trace of a cross-linking agent (sulfuric acid Aluminum, aluminum hydroxide) and water (the balance) totaling 100 g of A1 fluid efficacy composition raw material 22a is prepared.
The A1 fluid efficacy composition raw material 22a thus prepared has a fluid state in which it can flow in a temperature range of about 10° C. or higher as the first fluid temperature, and about 3° C. as the second cooling non-deformation temperature. In the following temperature range, it becomes a cuttable non-deformed state, and in the temperature range of about 7° C. to about 30° C. as the third non-fluid temperature, it becomes a water-containing gel-like softening effect composition without fluidity. In addition, in the temperature range of about 7° C. to about 30° C. as the third non-fluid temperature, the water-soluble polymer contained in the A1 fluidizing effect composition raw material 22a is crosslinked to form a three-dimensional network in the chemical structural formula. It has the property of changing into a water-containing gel-like softening composition having a non-fluid, sticky and shape-retaining structure upon aging. In addition, the water-containing gel-like softening composition that is in a non-flowing state at the third non-flowing temperature has the property of maintaining the non-flowing state even when the temperature is raised to about 40°C.
A patch comprising this water-containing gel-like softening composition has an effect of exhibiting a cooling effect or a cooling sensation effect when applied to the human body.
In addition, the A1 fluid efficacy composition raw material 22a undergoes a crosslinking reaction immediately after mixing with the crosslinking agent in an atmosphere of room temperature of about 25° C., and gradually changes from a gel-like fluid state to flexibility without fluidity. It has the property of aging and changing into a softening effect composition. Usually, the fluidity gradually decreases immediately after mixing the cross-linking agent, and after about 60 minutes, it becomes a non-fluid state with no fluidity. It has the property of being aged and changed into a softening effect composition having flexibility.

(Typical Example 1-2)
Fluid efficacy composition raw material preparation step for preparing A2 dynamic efficacy composition raw material 22a having a flowable fluid state:
Example 1-1 described above further includes a step of adding about 0.1 g of indomethacin as a medicinal ingredient having an analgesic and anti-inflammatory effect and mixing and dissolving. In this way, the A2 fluid efficacy composition raw material 22a in which each component is uniformly mixed is prepared.
The A2 fluid efficacy composition raw material 13a thus prepared has a fluid state in which it can flow in a temperature range of about 10°C or higher as the first fluidizing temperature, and about 3°C as the second cooling non-deformation temperature. In the following temperature range, it becomes a cuttable non-deformed state, and in the temperature range of about 7° C. to about 30° C. as the third non-fluid temperature, it becomes a water-containing gel-like softening effect composition without fluidity.
In addition, the water-soluble polymer contained in the A2 fluid efficacy composition raw material 22a is crosslinked in the temperature range of about 7° C. to about 30° C. as the third non-fluid temperature, and becomes a network structure in the chemical structural formula. , it has a property of being aged and changed into a water-containing gel-like softening composition having non-fluidity and adhesiveness and shape retention. In addition, the water-containing gel-like softening composition that is in a non-flowing state at the third non-flowing temperature has the property of maintaining the non-flowing state even when the temperature is raised to about 40°C.
A patch comprising this water-containing gel-like softening composition has a cooling effect or a cooling sensation effect as well as an analgesic and anti-inflammatory effect when applied to the human body.
In addition, the A1 flow benefit composition raw material 22a undergoes a cross-linking reaction immediately after mixing with the cross-linking agent in an atmosphere of room temperature of about 25° C., and gradually changes from a gel-like flow state to flexibility without fluidity. It has the property of aging and changing into a softening effect composition. Usually, the fluidity gradually decreases immediately after mixing the cross-linking agent, and after about 60 minutes, it becomes a non-fluid state with no fluidity. It has the property of being aged and changed into a softening effect composition having flexibility.

(Typical Example 2-1)
With regard to a typical example of a method for manufacturing a patch containing package containing a patch containing a water-containing gel-like softening composition exhibiting a cooling effect or a cooling sensation effect, the patch containing package shown in Fig. 1 will be described. A manufacturing method will be described.

・[Step A: Fluid efficacy composition raw material preparation step]:
A water-containing gel-like A1 flow benefit composition raw material 22a having crosslinkability prepared in (Typical Example 1-1) is prepared.

[Step B: Lamination member lamination step: Holding member/raw material for fluid composition/peel protection member lamination step]:
As shown in FIG. 1(B), a sample containing polyethylene terephthalate fibers, other fibers, a binder, etc., having a thickness of about 1 mm, a vertical width of about 50 mm, and a horizontal width of about 120 mm, has bending flexibility, stretchability, and air humidity. A holding member 21 made of a permeable needle-punched nonwoven fabric is prepared. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Separately, a peel protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 50 mm, and a width of about 120 mm is prepared.
In a room temperature atmosphere of about 25° C., the A1 fluid efficacy composition raw material 22a prepared in the above step A is added to the A1 fluid efficacy composition raw material 22a in a state where a holding member peripheral margin 21a of about 5 mm is formed on the surface of the holding member 21. Within about 20 minutes after the composition raw material is prepared, it is adhered and laminated in a shape of about 2 mm in thickness, about 40 mm in length, and about 110 mm in width. A peeling protective member 23 is laminated in such a manner as to cover the above, and thus a holding member/effective composition raw material/peeling protective member laminate is prepared.
In this step, a plastic frame having a vertical width of about 40 mm and a horizontal width of about 110 mm is placed inside the holding member peripheral margin 21a on the surface of the holding member 21, and a fluid gel is placed inside the frame. A1 fluid efficacy composition material 22a having a thickness of about 2 mm, a vertical width of about 40 mm, and a horizontal width of about 110 mm so as to form a holding member peripheral blank portion 21a by charging the A1 fluid efficacy composition material 22a. are laminated on the surface of the holding member 21 .

・ [C: Laminate packaging step] step:
As shown in FIG. 1(C), it consists of three layers of a polyethylene film (about 40 μm thick), an aluminum foil (about 9 μm thick), and a polyethylene terephthalate film (about 12 μm thick). A film-like packaging container 3 having a thickness of about 0.07 mm (about 70 μm) is prepared, which is bonded with a thick adhesive. Here, the film-like packaging container 3 has a state in which its periphery is opened, and at least the size of the holding member/effective composition raw material/peeling protective member laminate (vertical width of about 50 mm, horizontal width of about 120 mm) also has a shape larger than about 5 mm. Separately, prepare a vacuum packaging device (not shown) that is equipped with a vacuum pump and a heat sealing device inside the chamber and that can reduce the pressure inside the chamber.
In an atmosphere of room temperature of about 25° C., within about 30 minutes after preparation of the starting material for the A1 flowing benefit composition, the above-mentioned laminate of holding member, starting material for the benefit composition, and peeling protective member was placed with the polyethylene layers facing each other. Positioned between the two upper and lower film-like packaging containers 3, and in that state, the inside of the vacuum packaging device is decompressed to a reduced pressure state of about 100 mmHg or less, and the holding member/effective composition raw material/ A heat sealer is used to press and heat the opening of the peel protection member laminate at a distance of about 5 mm or more from the periphery of the peel protection member laminate, and the opening of the packaging container 3 is fused and welded to be sealed.
After that, the inside of the chamber is returned to atmospheric pressure (approximately 760 mmHg, normal pressure). As a result, the periphery of the packaging container 3 is heat-sealed, and the interior of the packaging container 3 is decompressed, and the holding member, the ingredient of the efficacy composition, and the peeling of the ingredients contained in the packaging container 3 are peeled off. In a state where the protective member laminate is positioned in the packaging container 3, the packaging container 3 is deformed along the shape of the holding member, the active composition raw material, and the peeling protective member laminate and is in a state of close contact. A product storage package is prepared. That is, due to the pressure difference between the inside and the outside of the packaging container, the packaging container 3 is deformed along the shape of the holding member/effective composition raw material/peeling protective member laminate and adheres to the laminate. product is obtained.
Here, the peel protection member 23 covers the surface and edges of the active composition raw material 22a and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in contact with the holding member and the active composition. It is possible to obtain a laminated product storage package that is deformed along the shape of the raw material/peeling protective member laminated product and is in close contact with the product.

・ [D: Ingredient aging step for efficacy composition] step:
As shown in (D) of FIG. 1, the laminate housing package prepared by the step (C) is placed in an atmosphere of room temperature of about 25° C. for about 60 minutes or more.
While being placed in an atmosphere of about 25° C., the fluid efficacy composition raw material 22a constituting the laminate storage package is crosslinked to the flexible efficacy composition 22 in a flexible state without fluidity to age and change. The softening composition 22 is adhered to the holding member 21 to form a holding member/softening composition/peel protection member laminate in which the softening composition 22 is adhered/bonded to the holding member 21 . As a result, the adhesive patch 2 provided with the holding member, the softening composition, and the peeling protection member, which has a configuration changed by maturing the fluid composition raw material 22a into the flexible composition 22 having stickiness and no fluidity. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.

Here, the packaging container 3 is kept in close contact with the surface and edges of the fluid efficacy composition material 22a and the peripheral blank portion 21a of the holding member 21 via the peel protection member 23. 22a is crosslinked with a softening composition 22 to be aged, and the patch 2 comprising a holding member, a softening composition and a peel protection member laminate is stored in a packaging container 3. is obtained. That is, the peel protection member 23 covers the surface and edges of the flexible composition 22 and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in a state where the holding member and the flexible composition are in close contact. It is possible to obtain an adhesive patch storage package that is deformed along the shape of the object/peeling protective member laminate and adheres to the laminate. In particular, the softening composition 22 is adhered to the surface of the holding member 21 while forming the peripheral margin 21a of the holding member 21 without protruding from the surface of the holding member 21, thereby obtaining a patch containing package.

In addition, due to the pressure difference between the inside and outside of the packaging container, the effective composition raw material 22a adhering to the surface of the holding member 21 made of nonwoven fabric having a fine uneven surface is held through the peeling protection member 23. The holding member 21 and the efficacy composition raw material 22a are pressed against each other while being sandwiched between the film-like packaging containers located on the front side and the back side of the laminate of the member/effective composition raw material/peeling protective member. As a result, a state is formed in which part of the effective composition raw material 22a enters into the unevenness of the fine uneven surface of the holding member 21, and in this state, the effective composition raw material 22a is crosslinked and matured to lose fluidity. It is transformed into the softening composition 22 in the softening state. In this way, a patch is formed in which the softening composition 22 in a soft state is joined to the holding member 21 without being peeled off.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

In the method for manufacturing the patch containing packaged product of this embodiment or the patch containing packaged product of this embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect B] and [Method Effect A] are obtained. Effect C], [Method Effect Kuke], [Method Effect C-a], [Method Effect C-a], [Method Effect C-b], [Composition Effect A], [Composition Effect C], [Construction Effect C ], [Structure effect S], [Structure effect S-b], [Structure effect C-a], etc. are obtained.

In the aforementioned step (C) of the present embodiment, the same effect as described above can be obtained even in a structure in which the inside of the vacuum packaging apparatus is decompressed to a decompressed state of about 600 mmHg. Also, the same effect as described above can be obtained with a configuration in which the inside of the vacuum packaging apparatus is decompressed to a decompressed state of about 30 mmHg.

(Typical Example 2-2)
An example of a patch containing package comprising a water-containing gel-like softening composition exhibiting a cooling effect or a cooling effect and an analgesic and anti-inflammatory effect will be described.
In the exemplary embodiment 2 described above, instead of the A1 fluid benefit composition ingredient 22a,
Prepare the crosslinkable water-containing gel-like A2 fluid effective composition raw material 22a having an analgesic effect prepared in (Typical Example 1-2).
Other steps are the same as the steps of (Typical Example 2-1) described above.
As a result, the adhesive patch 2 provided with the holding member, the softening composition, and the peeling protection member, which has a configuration changed by maturing the fluid composition raw material 22a into the flexible composition 22 having stickiness and no fluidity. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

In the manufacturing method of the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect B] and [Method Effect A] are obtained. Effect C], [Method Effect Kuke], [Method Effect C-a], [Method Effect C-a], [Method Effect C-b], [Composition Effect A], [Composition Effect C], [Construction Effect C ], [Structure Effect S], [Structure Effect S-b], [Structure Effect C-a], and [Method Effect S], [Structure Effect S], etc. are obtained.

(Comparative Example 2a)
In the exemplary embodiment 2-1, the following steps partially similar to the conventional manufacturing steps shown in FIG. 12 are provided instead of the respective steps.
- [step similar to step (a) in FIG. 12]:
In a room temperature atmosphere of about 25° C., the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-1) is prepared.

・[Step similar to step (b-a) in FIG. 12]:
A holding member 21 made of a needle-punched non-woven fabric having bending flexibility, stretchability, and air humidity permeability and having a thickness of about 1 mm, a vertical width of about 50 mm, and a horizontal width of about 120 mm, containing polyethylene terephthalate fibers, other fibers, binders, etc. to prepare. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids between tangled fibers and a fine uneven surface.
Separately, a peeling protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 50 mm, and a width of about 120 mm is prepared.
In a room temperature atmosphere of about 25° C., the A1 fluid efficacy composition raw material 22a prepared in the A step is added to the A1 fluid efficacy composition in a state where a holding member peripheral margin 21a of about 5 mm is formed on the surface of the holding member 21. Within about 20 minutes after the preparation of the raw materials, they are transferred and laminated, and the peeling protective member 23 is laminated. In this way, the peeling protection member 23 is laminated in a state of covering the flow benefit composition raw material 22a having a thickness of about 2 mm, a length of about 40 mm, and a width of about 110 mm and the holding member peripheral margin 21a, thereby forming a holding member/benefit composition. A raw material/release protection member laminate is prepared. In this step, a plastic frame having a vertical width of about 40 mm and a horizontal width of about 110 mm is placed inside the holding member peripheral margin 21a on the surface of the holding member 21, and a fluid gel is placed inside the frame. A1 fluid efficacy composition material 22a having a thickness of about 2 mm, a vertical width of about 40 mm, and a horizontal width of about 110 mm so as to form a holding member peripheral blank portion 21a by charging the A1 fluid efficacy composition material 22a. are laminated on the surface of the holding member 21 .

・ [Steps similar to FIG. 12 (b-c) step, (c-a) step]:
While being placed in an atmosphere of about 25° C., the fluidizing composition raw material 22a is cross-linked to the softening composition 22 in a non-fluid state to be aged and changed, and the softening composition 22 is retained. It is adhered to the member 21 to form a retaining member/softening composition/peel protection member laminate in which the softening composition 22 is adhered to the retaining member 21 . As a result, the flowing effect composition raw material 22a is aged into the softening effect composition 22 to form the adhesive patch 2 having the holding member, the softening effect composition, and the peeling protection member having a changed configuration.
Here, in the holding member/flowing effect composition material/peeling protective member, as shown in FIG. Therefore, the thickness H of the fluid efficacy composition raw material 22a is reduced to a thickness H2, and the fluid efficacy composition raw material 22a protrudes from the end surface of the holding member 21 by a length L2. Become.
Then, as shown in FIG. 12(c-a), with the lapse of time, the fluidizing effect composition raw material 22a is crosslinked from the fluid state to the softening effect composition 22 in a non-fluid state, and is aged and changed. At the same time, the softening composition 22 is adhered and bonded to the holding member to obtain a patch comprising a laminate of the retaining member, the softening composition and the peeling protective member in which the softening composition 22 is adhered and bonded to the holding member. Here, the protruding fluid benefit composition raw material 22a is also aged and changed from the fluid state to the flexible benefit composition 22 having adhesiveness without fluidity.

・[step similar to step (d-a) in FIG. 12]:
A film-like packaging container 3 having a thickness of about 0.1 mm or less is prepared, which is the same as that used in the exemplary embodiment 2-1, and the above ( c-b) With the patch prepared in the step placed, the opening of the packaging container 3 in a region spaced apart by about 5 mm or more from the periphery of the patch is pressed and heated by a heat sealer, The opening of the packaging container 3 is fused and joined to be sealed. In this way, a patch-containing packaged product in which the patch is stored in the packaging container 3 is obtained. Here, the packaging container 3 is not housed in a state of being in close contact with the patch.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.
That is, a patch containing package 1 in which the softening composition 22 protrudes from the end surface of the patch is obtained.

(Comparative Example 2b)
In the exemplary embodiment 2-1, the following steps partially similar to the conventional manufacturing steps shown in FIG. 12 are provided instead of the respective steps.
[Step A of Typical Example 2-1 (step corresponding to step of preparing raw material for fluid efficacy composition): [step similar to step (a) in FIG. 12]:
In a room temperature atmosphere of about 25° C., the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-1) is prepared.

[Step B of Typical Example 2-1 (Lamination member lamination step: a step corresponding to the step of lamination of the holding member/fluid composition raw material/peeling protective member)]: [Step similar to step (b-a) in FIG. ]:
A holding member 21 made of a needle-punched nonwoven fabric having bending flexibility, stretchability, and air humidity permeability and having a thickness of about 1 mm, a vertical width of about 50 mm, and a horizontal width of about 120 mm, containing polyethylene terephthalate fibers, other fibers, binders, etc. prepare. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Separately, a peel protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 50 mm, and a width of about 120 mm is prepared.
In an atmosphere of room temperature of about 25° C., the A1 fluid efficacy composition raw material 22a prepared in step A is added to the A1 fluid efficacy composition in a state where a holding member peripheral blank portion 21a of about 5 mm is formed on the surface of the holding member 21. Within about 20 minutes after the preparation of the raw materials, they are transferred and laminated, and the peeling protection member 23 is laminated. In this way, the peeling protection member 23 is laminated in a state of covering the flow benefit composition raw material 22a having a thickness of about 2 mm, a length of about 40 mm, and a width of about 110 mm and the holding member peripheral margin 21a, thereby forming a holding member/benefit composition. A raw material/release protection member laminate is prepared. In this step, a plastic frame having a vertical width of about 40 mm and a horizontal width of about 110 mm is placed inside the holding member peripheral margin 21a on the surface of the holding member 21, and a fluid gel is placed inside the frame. A1 fluid efficacy composition material 22a having a thickness of about 2 mm, a vertical width of about 40 mm, and a horizontal width of about 110 mm so as to form a holding member peripheral blank portion 21a by charging the A1 fluid efficacy composition material 22a. are laminated on the surface of the holding member 21 .

・ [C: Laminate packaging step] step:
Prepare a film-like packaging container 3 having a thickness of about 0.1 mm or less, which is the same as that used in Typical Example 2-1,
In a room temperature atmosphere of about 25° C. and a normal pressure atmosphere, within about 30 minutes after the preparation of the A1 flow benefit composition raw material, the above-mentioned holding member/benefit composition raw material/peeling protective member laminate was coated with the polyethylene layer. A region positioned between two upper and lower film-like packaging containers 3 facing each other and spaced apart by about 5 mm or more from the periphery of the holding member/effective composition raw material/peeling protective member laminate. The opening is pressed and heated by a heat sealer, and the opening of the packaging container 3 is fused and welded to be sealed. In this way, a laminate-containing packaged product is obtained in which the holding member, the effective composition raw material, and the peel-protective member laminate are hermetically housed in the packaging container 3 . Here, the packaging container 3 is not accommodated in a state in which it is in close contact with the holding member/effective composition raw material/peeling protective member laminate.

・[D: Effective composition raw material maturing step] step:
The laminate housing package prepared by the above step (C) is placed in an atmosphere of room temperature of about 25° C. for about 60 minutes or longer.
While being placed in an atmosphere of about 25° C., the fluidizing composition raw material 22a is cross-linked to the softening composition 22 in a non-fluid state to be aged and changed, and the softening composition 22 is retained. It is adhered to the member 21 to form a retaining member/softening composition/peel protection member laminate in which the softening composition 22 is adhered to the retaining member 21 . As a result, the flowable efficacy composition raw material 22a is matured into the softening efficacy composition 22 to form the patch 2 including the holding member, the softening efficacy composition, and the peeling protection member, and the patch 2 is formed. is stored in the packaging container 3 to obtain the patch containing package 1.
Here, in the holding member/flowing effect composition material/peeling protective member, as shown in FIG. Therefore, the thickness H of the fluid efficacy composition raw material 22a is reduced to a thickness H2, and the fluid efficacy composition raw material 22a protrudes from the end face of the holding member 21 by a length L2. Become.
Then, as shown in FIG. 12(d-a), with the lapse of time, the fluid composition raw material 22a is crosslinked from the fluid state to the flexible composition 22 in the non-fluid state, and is aged and changed. At the same time, the softening composition 22 is adhered and bonded to the holding member, and the patch containing the patch comprising the holding member, the softening composition, and the peeling protective member laminate in which the softening composition 22 is adhered and bonded to the holding member. Agent 2 is obtained. Here, the protruding fluid benefit composition raw material 22a is also matured and changed from the fluid state to the flexible benefit composition 22 having adhesiveness without fluidity.
That is, a patch containing package 1 in which the softening composition 22 protrudes from the end surface of the patch is obtained.

(Comparative Example 2c)
(Comparative Example 2c)
As a packaging container, a patch storage package comprising a packaging container comprising a blister-type container body having a housing recess with an open top surface and a flange formed around the periphery of the recess and a container lid will be described. . In general, the blister-type container body is preferably made of a material designed to have mechanical strength to withstand the force applied during transportation, distribution, storage, and the like. That is, the blister-type container main body is constructed so as to have mechanical strength to withstand external pressure and be configured not to be deformed by external pressure. In this comparative example, as the blister-type container main body, a housing recess (about 55 mm in width, about 125 mm in length, and about 3 mm in depth) with an open top and a flange (about 5 mm in width of the flange) formed on the periphery of the recess were used. A blister type container made of PET (polyethylene terephthalate) having a thickness of about 0.7 mm is constructed. The size of the accommodating recess of the blister-type container is about 5 mm or more larger than the size of the holding member/effective composition raw material/peeling protective member laminate (length: about 50 mm, width: about 120 mm). As the container cover, a laminated film which is made of the same material as that of the packaging container constructed in Typical Example 2-1 and which can be heat-sealed and has flexibility to be deformed is constructed.

・[Step A: Fluid efficacy composition raw material preparation step]:
A crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-1) is prepared.
・[Step B: Laminating member laminating step: Holding member/raw material for fluid efficacy composition/peeling protective member laminating step]:
A holding member/effective composition raw material/peeling protective member laminate is prepared by the same steps as in (Typical Example 2-1) described above.

・ [C: Laminate packaging step] step:
In an atmosphere of room temperature of about 25° C., within about 30 minutes after the preparation of the A1 flowable efficacy composition raw material, the holding member/beneficial composition raw material/peeling protective member laminate prepared by the above step (B) is packaged. In this state, the inside of the vacuum packaging device is evacuated to a reduced pressure state of about 100 mmHg or less, and the brim of the blister type container body and the container lid are melted and fused together in the reduced pressure state. are joined and sealed. After that, the inside of the chamber is returned to normal pressure (about 760 mmHg). As a result, the periphery of the packaging container 3 is thermally fused and sealed, and a laminate containing package is prepared in which the interior of the packaging container 3 is in a decompressed state.
Here, the container lid of the laminated product storage package formed is deformed along the shape of the holding member/effective composition raw material/peeling protection member laminate and brought into close contact. However, the blister-type container main body maintains the same shape as before vacuum sealing without deformation.

・[D: Effective composition raw material maturing step] step:
By a process similar to that of (Typical Example 2-1) described above, the laminate housing package prepared by the process (C) is placed in an atmosphere of room temperature of about 25° C. for about 60 minutes or longer. As a result, the fluidizing composition raw material 22a is matured into the flexible composition 22 having stickiness and lacking fluidity, and thus the adhesive patch 2 is equipped with a holding member, a flexible composition, and a peeling protective member. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.
At this point, the fluid composition raw material 22a protrudes from the periphery of the holding member 21, and in this protruding state, is crosslinked with the softening composition 22 and matured to form the holding member, the softening composition, and the peeling protection member. A patch containing package 1 is obtained in which the patch 2 provided with the laminate is housed in the packaging container 3 .
That is, a patch containing package 1 in which the softening composition 22 protrudes from the end surface of the patch is obtained.

(Summary of states of patch containing packages manufactured in Comparative Example 2a, Comparative Example 2b, and Comparative Example 2c)
In any of the patch containing packages of Comparative Example 2a, Comparative Example 2b, and Comparative Example 2c, the flexible and beneficial composition between the holding member and the peeling protective member There is a tendency for defects to be produced in which the patch protrudes from the edge of the gap. When the adhesive patch that constitutes the protruding functional softening composition is placed in a packaging container, the protruding functional softening composition adheres to the inner surface of the packaging container, making it easy to remove the patch from the packaging container. There is a tendency for the inconvenience of not having one. Furthermore, when the patch is applied to the skin of the human body, the protruding composition for softening exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, and the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, there is a tendency that a portion of the back side of the holding member is sticky, giving an unpleasant feeling.

(Typical Example 3-1)
Manufacture of a patch storage package containing a water-containing gel-like softening composition:
A typical embodiment of a method for manufacturing a patch containing package including a step of cooling the effective composition raw material shown in FIG. 2 will be described.

・[Step A: Fluid efficacy composition raw material preparation step]:
A water-containing gel-like crosslinkable A1 flow benefit composition raw material 22a prepared in (Typical Example 1-1) is prepared. In a room temperature atmosphere of about 25° C., the hydrous gel-like A1 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 40 mm, a width of about 110 mm, and a height of about 2 mm or more so that the thickness is about 2 mm. put into
・[(A) Cooling predetermined shape forming step]:
The polystyrene container containing the fluid benefit composition material 22a is cooled to a second cooling non-deformation temperature of about -10°C to about 3°C at which the fluid benefit composition material 22a is in a non-deformed state, and the fluid benefit composition material 22a is brought into a non-deformed state. A chilled undeformed benefit composition stock 22b is prepared. As a result, a cooled non-deformed effective composition material 22b in a non-deformed state having a thickness of about 2 mm, a vertical width of about 40 mm and a horizontal width of about 110 mm is prepared.

[Step B: Laminating member laminating step: Holding member/raw material for cooling non-deforming effect composition/peeling protective member laminating step]:
As shown in FIG. 2A, a peeling protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a vertical width of approximately 50 mm, and a horizontal width of approximately 120 mm is separately prepared.
In an atmosphere of room temperature of about 25° C., the cooled non-deformable effective composition raw material 22b prepared in the above step A is laminated in a state where the holding member peripheral margin 21a of about 5 mm is formed on the surface of the holding member 21, The peel protective member 23 is laminated so as to cover the cooled non-deformed effective composition raw material 22b and the holding member peripheral margin 21a, thus preparing a holding member/effective composition raw material/peeling protective member laminate. Here, the cooled non-deformed benefit composition material 22b maintains the non-deformed state.

・ [C: Laminate packaging step] step:
As shown in FIG. 2(B), a sample containing polyethylene terephthalate fibers, other fibers, a binder, etc., having a thickness of about 1 mm, a vertical width of about 50 mm, and a horizontal width of about 120 mm, has bending flexibility, stretchability, and air humidity. A holding member 21 made of a permeable needle-punched nonwoven fabric is prepared. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Also, a film-like packaging container 3 having a thickness of about 0.1 mm or less, which is composed of three layers of a polyethylene film, an aluminum foil, and a polyethylene terephthalate film, is prepared. Here, the film-like packaging container 3 has a state in which its periphery is opened.
The non-deformable cooling effect composition raw material 22b and the peeling protection member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peeling protection member 23 positioned on the surface side to form the holding member/effective composition raw material/peeling. A protective member laminate is prepared. Here, the cooled non-deformed benefit composition raw material 22b maintains the non-deformed state.
Separately, prepare a vacuum packaging device (not shown) that is equipped with a vacuum pump and a heat sealing device inside the chamber and that can reduce the pressure inside the chamber.
In an atmosphere of room temperature of about 25° C., the holding member/effective composition raw material/peeling protective member laminate is placed between two upper and lower film-like packaging containers 3 positioned with the polyethylene layers facing each other. In this state, the inside of the vacuum packaging device was evacuated to a reduced pressure state of about 100 mmHg or less, and a space of about 5 mm or more was provided from the periphery of the holding member/effective composition raw material/peeling protective member laminate in the reduced pressure state. The opening of the region is pressed and heated by a heat sealer, and the opening of the packaging container 3 is fused and welded to be sealed.
After that, the inside of the chamber is returned to normal pressure (about 760 mmHg). As a result, the periphery of the packaging container 3 is heat-sealed, and the interior of the packaging container 3 is decompressed, and the holding member, the ingredient of the efficacy composition, and the peeling of the ingredients contained in the packaging container 3 are peeled off. In a state where the protective member laminate is positioned in the packaging container 3, the packaging container 3 is deformed along the shape of the holding member, the active composition raw material, and the peeling protective member laminate and is in a state of close contact. A product storage package is prepared. That is, due to the pressure difference between the inside and the outside of the packaging container, the packaging container 3 is deformed along the shape of the holding member/effective composition raw material/peeling protective member laminate and adheres to the laminate. product is obtained.
In this state, the peel protection member 23 covers the surface and edges of the cooling non-deformable effective composition raw material 22b and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in contact with the holding member. - A laminate-containing packaging product can be obtained that deforms along the shape of the active composition raw material/peel protection member laminate and adheres to the laminate. Here, the cooled non-deformed benefit composition material 22b maintains the non-deformed state.

・ [D: Ingredient aging step for efficacy composition] step:
As shown in (D) of FIG. 2, the laminate housing package prepared in the step (C) is placed in an atmosphere of room temperature of about 25° C. for about 60 minutes or longer.
In a state of being placed in an atmosphere of about 25°C, the cooled non-deformed effect composition raw material 22b constituting the laminate storage package becomes flexible without fluidity during the process of raising the temperature to about 25°C and at about 25°C. A holding member in which the softening composition 22 is crosslinked and aged and changed, and the softening composition 22 is adhered and joined to the holding member 21, and the softening composition 22 is adhered and joined to the holding member 21. A benefit composition-release protection member laminate is formed. As a result, the cooled non-deformable effect composition raw material 22b is matured into the softening effect composition 22 having stickiness and lacking fluidity, and thus affixed with a holding member, a softening effect composition, and a peel protection member having a changed configuration. A patch-containing package 1 in which the patch 2 is formed and the patch 2 is stored in the packaging container 3 is obtained.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

Here, the packaging container 3 is kept in close contact with the surface and edges of the cooled non-deformed effective composition raw material 22b and the peripheral margin 21a of the holding member 21 via the peel protection member 23. A patch containing package 1 in which a raw material is crosslinked with a softening effect composition 22 and aged, and the patch 2 provided with a holding member/softening effect composition/peeling protection member laminate is housed in a packaging container 3. is obtained. That is, the peel protection member 23 covers the surface and edges of the flexible composition 22 and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in a state where the holding member and the flexible composition are in close contact. It is possible to obtain an adhesive patch storage package that is deformed along the shape of the object/peeling protective member laminate and adheres to the laminate. In particular, the softening composition 22 is adhered to the surface of the holding member 21 while forming the peripheral margin 21a of the holding member 21 without protruding from the surface of the holding member 21, thereby obtaining a patch containing package.

In addition, due to the pressure difference between the inside and the outside of the packaging container, the cooling non-deformable effective composition raw material 22b adhering to the surface of the holding member 21 made of nonwoven fabric having a fine uneven surface is removed through the peeling protection member 23. The holding member 21 and the cooled non-deformed effective composition raw material 22b are sandwiched between the film-like packaging containers located on the front side and the back side of the holding member/effective composition raw material/peeling protective member laminate. are pressed against each other. During the process of raising the temperature to about 25° C. and at about 25° C., the cooled non-deformed beneficial composition raw material 22 b changes into the form of the beneficial composition raw material 22 a having flowability, and part of the beneficial composition raw material 22 a is attached to the holding member 21 . A state is formed in which the material enters into the unevenness of the surface of the fine unevenness, and in this state, the ingredients of the benefit composition are crosslinked and matured to change into the softening benefit composition 22 in a flexible state without fluidity. In this way, a patch is formed in which the softening composition 22 in a soft state is joined to the holding member 21 without being peeled off.

In the method for manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect C] and [Method Effect C] are obtained. Effect C], [Method Effect C-a], [Method Effect C-a], [Construction Effect C-b], [Method Effect C], [Construction Effect C], [Construction Effect C], [Construction Effect C ], [Construction Effect C-a], [Construction Effect C-b], [Construction Effect C-a], etc. are obtained.

In the aforementioned step (C) of the present embodiment, the same effect as described above can be obtained even in a structure in which the inside of the vacuum packaging apparatus is decompressed to a decompressed state of about 600 mmHg. Also, the same effect as described above can be obtained with a configuration in which the inside of the vacuum packaging apparatus is decompressed to a decompressed state of about 30 mmHg.

(Typical Example 3-2)
An example of a patch containing package comprising a water-containing gel-like softening composition exhibiting a cooling effect or a cooling effect and an analgesic and anti-inflammatory effect will be described.
In the exemplary embodiment 3-1 described above, instead of the A1 fluid efficacy composition raw material 22a,
Prepare the crosslinkable water-containing gel-like A2 fluid effective composition raw material 22a having an analgesic effect prepared in (Typical Example 1-2).
The other steps comprise the same steps as those of (Exemplary Example 3) described above.
As a result, the fluidizing composition raw material 22a is matured into the flexible composition 22 having stickiness and lacking fluidity, and thus the adhesive patch 2 is equipped with a holding member, a flexible composition, and a peeling protective member. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.

In the method for manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect C] and [Method Effect C] are obtained. Effect C], [Method Effect C-a], [Method Effect C-a], [Construction Effect C-b], [Method Effect C], [Construction Effect C], [Construction Effect C], [Construction Effect C ], [Structure Effect C], [Structure Effect S-b], [Structure Effect C-a], and [Method Effect S], [Structure Effect S], etc. are obtained.

(Comparative Example 3)
A patch containing package containing a patch is prepared by the same manufacturing method as in Comparative Examples 2a and 2b.
As a result, in any of the patch containing packages, a patch was produced in which the softening composition composed between the holding member and the peeling protective member protruded from the edge between the holding member and the peeling protective member. There will be a defect that it will be done. When the patch comprising the protruding composition for softening is placed in a packaging container, the composition for softening that protrudes adheres to the inner surface of the packaging container, making it easy to remove the patch from the packaging container. There is an inconvenience that there is no Furthermore, when the patch is applied to the skin of the human body, the softening composition protruding from the patch exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, or the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, a part of the back side of the holding member becomes sticky, giving an unpleasant feeling.

(Typical Example 4-1)
Manufacture of a patch storage package containing a water-containing gel-like softening composition:
A typical example of a method for manufacturing an adhesive patch containing package comprising the steps of cooling and cutting the effective composition raw material shown in FIG. 3 will be described.
The manufacturing method of the adhesive patch containing package of the present embodiment includes the following steps.
[Step A: step of preparing raw material for fluid efficacy composition and step of forming predetermined shape by cooling and cutting]:
As shown in FIG. 3(A), the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-1) is prepared. In a room temperature atmosphere of about 25° C., the hydrous gel-like A1 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 120 mm, a width of about 330 mm, and a height of about 2 mm or more so that the thickness is about 2 mm. put into
As shown in FIG. 3(A), the flow benefit composition raw material 22a contained in a polystyrene container is cooled to a second cooling non-deformation temperature of about -10 to about 3° C. where it is in a non-deformed state. , forming a cooled non-deformed benefit composition raw material in a non-deformed state, and then cutting the cooled non-deformed benefit composition raw material 22b into a plurality of (nine) predetermined shapes (length about 40 mm, width about 110 mm). , a substantially rectangular sheet with a height of about 2 mm) is prepared.
In this step, a double-edged die with a tip edge angle of 30 degrees and a height of about 5 mm is attached to the upper plate of the flat plate cutting device, and the cooled non-deformed effective composition raw material 22b in the cooled state is cut into the flat plate cutting device. The upper plate is operated to cut the cooled non-deformed effect composition raw material 22b to obtain the cut cooled non-deformed effect composition raw material 22c in the form of a rectangular sheet.
At the time of cutting, the cooled non-deformed benefit composition raw material 22b is cut without flowing or deformed to obtain the desired cut cooled non-deformed benefit composition raw material 22c in the desired sheet-like rectangular shape which is accurately separated. Ta. That is, the cut and cooled non-deformed effective composition raw material 22c having a desired shape with high accuracy in desired thickness, area, shape, weight, etc. was obtained. In addition, deposits such as residues of the cooling non-deformation composition were not observed on the cutting edge of the press cutting blade type after the cutting operation.

・ [B process: Lamination member lamination process]:
As shown in FIG. 3B, a holding member 21 made of the same nonwoven fabric as the holding member made of nonwoven fabric constructed in the exemplary embodiment 3-1, and a peel protection member 23 are prepared.
The cut cooling non-deformable composition raw material 22c prepared in step A is layered on the surface of the holding member 21 while forming a margin 21a on the periphery of the holding member 21 with a thickness of about 5 mm. The peeling protective member 23 is laminated while covering the substance 22c and the holding member peripheral margin 21a, and thus the holding member/effective composition raw material/peeling protective member laminate is prepared. Here, the cut-cooled non-deformed benefit composition raw material 22c maintains the non-deformed state.

・ [C: Laminate packaging step] step:
As shown in FIG. 3(C), a flexural flexibility, stretchability, and air humidity of about 1 mm in thickness, about 50 mm in length, and about 120 mm in width containing polyethylene terephthalate fibers, other fibers, binders, etc. A holding member 21 made of a permeable needle-punched nonwoven fabric is prepared. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Also, a film-like packaging container 3 having a thickness of about 0.1 mm or less, which is composed of three layers of a polyethylene film, an aluminum foil, and a polyethylene terephthalate film, is prepared. Here, the film-like packaging container 3 has a state in which its periphery is opened.
The cut and cooled non-deformed beneficial composition raw material 22c and the peelable protective member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peelable protective member 23 positioned on the surface side to form a holding member/effective composition raw material/ A peel protection member laminate is prepared. Here, the cut-cooled non-deformed benefit composition raw material 22c maintains the non-deformed state.
Separately, prepare a vacuum packaging device (not shown) that is equipped with a vacuum pump and a heat sealing device inside the chamber and that can reduce the pressure inside the chamber.

In an atmosphere of room temperature of about 25° C., the holding member/effective composition raw material/peeling protective member laminate is placed between two upper and lower film-like packaging containers 3 positioned with the polyethylene layers facing each other. In this state, the inside of the vacuum packaging device was evacuated to a reduced pressure state of about 100 mmHg or less, and a space of about 5 mm or more was provided from the periphery of the holding member/effective composition raw material/peeling protective member laminate in the reduced pressure state. The opening of the region is pressed and heated by a heat sealer, and the opening of the packaging container 3 is fused and welded to be sealed.
After that, the inside of the chamber is returned to normal pressure (about 760 mmHg). As a result, the periphery of the packaging container 3 is heat-sealed, and the interior of the packaging container 3 is decompressed, and the holding member, the ingredient of the efficacy composition, and the peeling of the ingredients contained in the packaging container 3 are peeled off. In a state where the protective member laminate is positioned in the packaging container 3, the packaging container 3 is deformed along the shape of the holding member, the active composition raw material, and the peeling protective member laminate and is in a state of close contact. A product storage package is prepared. That is, due to the pressure difference between the inside and the outside of the packaging container, the packaging container 3 is deformed along the shape of the holding member/effective composition raw material/peeling protective member laminate and adheres to the laminate. product is obtained.
In this state, the peel protection member 23 covers the surface and edges of the cut and cooled non-deformable effective composition raw material 22c and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is held. It is possible to obtain a laminate-containing packaging product that deforms along the shape of the laminate of the member, the raw material of the efficacy composition, and the peeling protective member and adheres to the laminate. Here, the cut-cooled non-deformed benefit composition raw material 22c maintains the non-deformed state.

・[D: Effective composition raw material maturing step] step:
As shown in (D) of FIG. 3, the laminate housing package prepared by the step (C) is placed in a room temperature atmosphere of about 25° C. for about 60 minutes or longer.
While being placed in an atmosphere of about 25°C, the cut and cooled non-deformed active composition raw material 22c that constitutes the laminate storage package loses fluidity during the process of raising the temperature to about 25°C and at about 25°C. A holding member in which the softening composition 22 in a soft state is crosslinked, aged and changed, and the softening composition 22 is adhered and joined to the holding member 21, and the softening composition 22 is adhered and joined to the holding member 21. A softening benefit composition/release protection member laminate is formed. As a result, the cut-cooled non-deformable benefit composition raw material 22c is matured into the softening benefit composition 22 having stickiness and no fluidity, thereby providing a holding member, a softening benefit composition, and a peel protection member having changed configurations. A patch containing package 1 is obtained in which the patch 2 is formed and the patch 2 is housed in the packaging container 3 .
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

Here, the packaging container 3 is kept in close contact with the surface and edges of the cut and cooled non-deformed active composition raw material 22c and the peripheral margin 21a of the holding member 21 via the peel protection member 23. A patch containing package product in which the patch 2 having a holding member, a softening composition and a peel protection member laminate is stored in a packaging container 3. 1 is obtained. That is, the peel protection member 23 covers the surface and edges of the flexible composition 22 and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in a state where the holding member and the flexible composition are in close contact. It is possible to obtain an adhesive patch storage package that is deformed along the shape of the object/peeling protective member laminate and adheres to the laminate. In particular, the softening composition 22 is adhered to the surface of the holding member 21 while forming the peripheral margin 21a of the holding member 21 without protruding from the surface of the holding member 21, thereby obtaining a patch containing package.

In addition, due to the pressure difference between the inside and outside of the packaging container, the cut cooling non-deformable effective composition raw material 22c adhering to the surface of the holding member 21 made of nonwoven fabric having a finely uneven surface peels off the peeling protective member 23. The holding member 21 and the cut/cooled undeformed beneficial composition are sandwiched between the film-like packaging containers positioned on the front side and the back side of the holding member/beneficial composition raw material/peeling protective member laminate via the holding member 21. The raw material 22c is pressurized against each other. During the process of raising the temperature to about 25° C. and at about 25° C., the cut-cooled non-deformed benefit composition raw material 22 c changes into the form of the beneficial composition raw material 22 a having flowability, and a part of the beneficial composition raw material 22 a is held by the holding member 21 . In this state, the ingredients of the benefit composition are crosslinked and matured to change into the softening benefit composition 22 in a flexible state without fluidity. In this way, a patch is formed in which the softening composition 22 in a soft state is joined to the holding member 21 without being peeled off.

In the method for manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and the aforementioned [Method Effect D] and [ Method Effect C], [Method Effect Kuke], [Method Effect C-a], [Method Effect C-a], [Method Effect C-b], [Method Effect S], [Composition Effect D], [Construction Effect [H], [Structure effect Kuke], [Structure effect S], [Structure effect S-a], [Structure effect S-b], [Structure effect C-a], etc. can be obtained.

In the aforementioned step (C) of the present embodiment, the same effect as described above can be obtained even in a structure in which the inside of the vacuum packaging apparatus is decompressed to a decompressed state of about 600 mmHg. Also, the same effect as described above can be obtained with a configuration in which the inside of the vacuum packaging apparatus is decompressed to a decompressed state of about 30 mmHg.

(Typical Example 4-2)
An example of a patch containing package comprising a water-containing gel-like softening composition exhibiting a cooling effect or a cooling effect and an analgesic and anti-inflammatory effect will be described.
In the exemplary embodiment 4-1 described above, instead of the A1 fluid efficacy composition raw material 22a,
Prepare the crosslinkable water-containing gel-like A2 fluid effective composition raw material 22a having an analgesic effect prepared in (Typical Example 1-2).
The other steps are the same as the steps of (Typical Example 4-1) described above.
As a result, the fluidizing composition raw material 22a is matured into the flexible composition 22 having stickiness and lacking fluidity, and thus the adhesive patch 2 is equipped with a holding member, a flexible composition, and a peeling protective member. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.

In the method for manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and the aforementioned [Method Effect D] and [ Method Effect C], [Method Effect Kuke], [Method Effect C-a], [Method Effect C-a], [Method Effect C-b], [Method Effect S], [Composition Effect D], [Construction Effect [H], [Structure effect Kuke], [Structure effect S], [Structure effect S-a], [Structure effect S-b], [Structure effect C-a], and [Method effect S], [Structure effect C] and the like can be obtained.

(Typical Example 4-3)
In [Step A: Predetermined shape forming step by cooling cutting] of the above-described exemplary embodiment 4-1,
The flowing benefit composition raw material 22a contained in a polystyrene container is cooled to a second cooling non-deformation temperature of about -10°C to about 3°C to a non-deformed state of the cooled non-deformed benefit composition. A raw material 22b is formed, and then the cooled undeformed benefit composition raw material 22b is cut to obtain cut cooled undeformed benefit composition raw material 22c of predetermined shape as shown in FIGS. A step of preparing is also feasible.
In this case, the holding member 21 and the peeling protective member 23 are constituted by the holding member 21 and the peeling protective member 23 having a shape similar to that of the cut-cooled non-deforming active composition raw material 22c.
10C and 10D, in the case of preparing the cut and cooled undeformed beneficial composition raw material 22c having through-holes, the holding member 21 is also cut and cooled undeformed beneficial composition raw material 22c. formed into a shape having the same through-hole as
Other steps are similar to those of typical example 4-1 described above. As a result, the patch containing package 1 in which the patch 2 is contained in the packaging container 3 is obtained.

In this embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and the aforementioned [Method Effect D], [Method Effect C], [Method Effect Kuke], and [Method Effect C-a] are obtained. , [method effect s-a], [method effect s-b], [method effect s], [composition effect d], [composition effect ku], [composition effect que], [composition effect s], [composition effect Effects such as [S-a], [Structured effect S-b], and [Structured effect C-a] can be obtained.

(Typical Example 4-4)
A water-containing gel-like A1 flow benefit composition raw material 22a having crosslinkability prepared in (Typical Example 1-1) is prepared.
In a room temperature atmosphere of about 25° C., the hydrous gel-like A1 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 110 mm, a width of about 50 mm, and a height of about 40 mm or more to a thickness of about 40 mm. be put in.
The following steps are provided in place of [Step A: Predetermined shape forming step by cooling cutting] of the aforementioned exemplary embodiment 4-1.
The flowable effect composition raw material 22a contained in a polystyrene container is cooled to a second cooling non-deformation temperature of about -10 to about 3°C, which is a non-deformed state, and the cooled non-deformed effect in the non-deformed state A composition raw material is formed, and then the cooled non-deformable effective composition raw material 22b is cut at intervals of about 2 mm to form a plurality of (25) predetermined shapes (length about 40 mm, width about 110 mm, height about 2 mm). ) to prepare cut cooled non-deformed benefit composition raw material 22c.
As a method for cutting the cooled non-deformable efficacy composition raw material 22b, cutting by using a blade similar to a kitchen knife or cutting by a wire can be implemented.
The other steps are the same as the steps of (Typical Example 4-1) described above.
As a result, the fluidizing composition raw material 22a is matured into the flexible composition 22 having stickiness and lacking fluidity, and thus the adhesive patch 2 is equipped with a holding member, a flexible composition, and a peeling protective member. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

In the method for manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and the aforementioned [Method Effect D], [method effect c], [method effect kuke], [method effect co-a], [method effect c-a], [method effect c-b], [method effect c], [configuration effect D], [configuration Effects such as Effect C], [Construction Effect Kuke], [Construction Effect Sa], [Construction Effect C-a], [Construction Effect C-b], and [Construction Effect C-a] are obtained.

(Comparative Example 4)
In the [Step A: Predetermined shape forming step by cooling cutting] of the aforementioned Typical Example 4-1, the length of about 120 mm, width of about 330 mm, A water-containing gel-like A1 flowing efficacy composition raw material 22a having a thickness of about 2 mm is cut into a length of about 40 mm, a width of about 110 mm, and a height of about 2 mm using a kitchen knife blade or a pressing blade without cooling. As a result of performing the cutting operation so as to form the material raw material 22c, after the cutting operation, the fluid efficacy composition raw material is immediately fluidized and deformed, and the cut fluid efficacy composition raw material is mixed with each other again, so that it can be cut accurately. I didn't.
Further, after the cutting operation, a large amount of residue of the fluid efficacy composition raw material adhered to the cutting edge of the press cutting blade 7 .
That is, in the method of this comparative example, there is a problem in manufacturing a patch containing package having a desired shape.

(Typical Example 5-1)
A typical example of a method for manufacturing a patch-containing package containing multiple types of ingredients for a softening and efficacy composition will be described. This embodiment relates to a patch containing package formed by laminating a plurality of types of cut cooled non-deformed effective composition raw materials cut in a cooled state, as shown in FIG.

[Step A: step of preparing raw material for fluid efficacy composition and step of forming predetermined shape by cooling and cutting]:
A water-containing gel-like crosslinkable A1 flow benefit composition raw material 22a prepared in (Typical Example 1-1) is prepared. Separately, the crosslinkable water-containing gel-like A2 fluid efficacy composition raw material 22a prepared in (Typical Example 1-2) is prepared.
In a room temperature atmosphere of about 25° C., the hydrous gel-like A1 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 140 mm, a width of about 200 mm, and a height of about 2 mm or more to a thickness of about 2 mm. be put in.
Separately, in a room temperature atmosphere of about 25° C., the water-containing gel-like A2 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 140 mm, a width of about 200 mm, and a height of about 2 mm or more to a thickness of about 2 mm. be put in.
The A1 fluid benefit composition material 22a placed in the polystyrene container prepared above and the A2 fluid benefit composition material 22a placed in the polystyrene container were heated at a temperature of about -10 to about 3°C. cooling to a second cooling undeformed temperature to an undeformed state to form an A1 cooled undeformed benefit composition feedstock in an undeformed state and an A2 cooled undeformed benefit composition feedstock in an undeformed state followed by A1 cooling; The non-deformed benefit composition raw material 22b and the A2 cooled non-deformed benefit composition raw material are cut into a plurality of A1 cut cooled non-deformed benefit compositions of a predetermined shape (approximately 140 mm in length, approximately 25 mm in width, and approximately 2 mm in height). Raw material 22c and A2 cut cooled undeformed benefit composition raw material 22c are prepared.

・ [B process: Lamination member lamination process]:
Holding member 21 made of needle-punched non-woven fabric having bending flexibility, stretchability, and air humidity permeability and having a thickness of about 1 mm, a vertical width of about 150 mm, and a horizontal width of about 110 mm, containing polyethylene terephthalate fibers, other fibers, binders, etc. to prepare. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Separately, a peeling protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 150 mm, and a width of about 110 mm is prepared.
In a room temperature atmosphere of about 25° C., as shown in FIG. A1-cut cooling non-deformable benefit composition raw material 22c and A2-cut cooling non-deformable benefit composition raw material 22c having a predetermined shape (approximately 140 mm in length, approximately 25 mm in width, and approximately 2 mm in height) are placed on the plane of the surface of holding member 21. Peel protection member 23 is laminated in a state adjacent to each other in the region and covers A1 cut cooled non-deformed effective composition raw material 22c, A2 cut cooled non-deformed effective composition raw material 22c and holding member peripheral margin 21a. are laminated to prepare a laminate of the holding member/effective composition raw material/peeling protective member.

・ [Step C: Laminate packaging step]:
A film-like packaging container 3 having a thickness of about 0.1 mm or less, which is composed of three layers of polyethylene film, aluminum foil, and polyethylene terephthalate film, is prepared. Here, the film-like packaging container 3 has a state in which its circumference is opened.
A1-cut cooling non-deformation effect composition material 22c and A2-cut cooling non-deformation effect composition material 22c peel protection member 23 are placed in a predetermined position area on the surface of holding member 21 with peel protection member 23 positioned on the surface side. By laminating, a holding member/effective composition raw material/peeling protective member laminate is prepared. Separately, prepare a vacuum packaging device (not shown) that is equipped with a vacuum pump and a heat sealing device inside the chamber and that can reduce the pressure inside the chamber.
In an atmosphere of room temperature of about 25° C., the holding member/effective composition raw material/peeling protective member laminate is placed between two upper and lower film-like packaging containers 3 positioned with the polyethylene layers facing each other. In this state, the inside of the vacuum packaging device was evacuated to a reduced pressure state of about 100 mmHg or less, and a space of about 5 mm or more was provided from the periphery of the holding member/effective composition raw material/peeling protective member laminate in the reduced pressure state. The opening of the region is pressed and heated by a heat sealer, and the opening of the packaging container 3 is fused and welded to be sealed.
After that, the inside of the chamber is returned to normal pressure (about 760 mmHg). As a result, the periphery of the packaging container 3 is heat-sealed, and the interior of the packaging container 3 is decompressed, and the holding member, the ingredient of the efficacy composition, and the peeling of the ingredients contained in the packaging container 3 are peeled off. In a state where the protective member laminate is positioned in the packaging container 3, the packaging container 3 is deformed along the shape of the holding member, the active composition raw material, and the peeling protective member laminate and is in a state of close contact. A product storage package is prepared. That is, due to the pressure difference between the inside and the outside of the packaging container, the packaging container 3 is deformed along the shape of the holding member/effective composition raw material/peeling protective member laminate and adheres to the laminate. product is obtained.
In this state, the peel protection member 23 covers the surface and edges of the cut and cooled non-deformable effective composition raw material 22c and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is held. It is possible to obtain a laminate-containing packaging product that deforms along the shape of the laminate of the member, the raw material of the efficacy composition, and the peeling protective member and adheres to the laminate.
In this step, the A1-cut cooled undeformed benefit composition material 22c and the A2-cut cooled undeformed benefit composition material 22c maintain their undeformed state.
In this way, while the holding member/effective composition raw material/release member laminate is positioned in the packaging container, the packaging container conforms to the shape of the holding member/effective composition raw material/release member laminate. The opening of the packaging container is sealed so that the laminate is deformed and brought into close contact with the container to prepare a laminate-accommodating package.

・ [Step D: Ripening step of ingredients for efficacy composition]:
(C) Place the laminate containing package prepared in the step in an atmosphere of room temperature of about 25° C. for about 60 minutes or longer.
In an atmosphere of about 25°C, the A1 adiabatic cooling non-deformation composition raw material 22c and the A2 adiabatic cooling non-deformation composition raw material 22c constituting the laminate storage package are heated to about 25°C and about 25°C. , the A1 softening composition 22 and the A2 softening composition 22 in a soft state without fluidity are crosslinked to be aged and changed, and the A1 softening composition 22 and the A2 softening composition 22 are bonded to each other. In this state, it is adhered and joined to the holding member 21 to form a holding member/softening composition/peel protection member laminate. As a result, a patch comprising a holding member, a softening composition, and a peeling protection member having a configuration that has been changed by maturing each of the active composition raw materials into a flexible composition having no fluidity is formed, and A patch containing package is obtained in which the patch is contained in the packaging container.
In this way, a patch containing package containing a patch having a size of about 150 mm in length and about 110 mm in width is obtained.

Here, the packaging container 3 is separated from the surface and edges of the A1-cut cooled non-deformed effective composition raw material 22c and the A2-cut cooled non-deformed effective composition raw material 22c through the peel protection member 23, and the peripheral blank portion 21a of the holding member 21. While maintaining the state of being in close contact with each other, the respective benefit composition raw materials are crosslinked with the A1 softening benefit composition 22 and the A2 softening benefit composition 22 and aged to form a lamination of the holding member, softening benefit composition, and peel protection member. A patch-containing package 1 is obtained in which the patch 2 provided with an object is stored in the packaging container 3 . That is, the peeling protection member 23 covers the surfaces and edges of the A1 softening composition 22 and the A2 softening composition 22 and is in close contact with the peripheral margin 21a of the holding member 21. 3 is deformed along the shape of the holding member/flexible efficacy composition/peel protection member laminate and closely adhered thereto. In particular, the softening composition 22 and the A2 softening composition 22 are adhesive patches formed on the surface of the holding member 21 in such a manner that the peripheral blank portion 21a of the holding member 21 is formed without protruding from the surface of the holding member 21. A storage package is obtained.

In addition, due to the pressure difference between the inside and the outside of the packaging container, the A1 cut and cooled non-deformed effective composition raw material 22c and the A2 cut and cooled non-deformed efficacy composition raw material 22c adhering to the surface of the nonwoven fabric holding member 21 having a fine uneven surface In a state in which the modified efficacy composition raw material 22c is sandwiched between the film-like packaging containers positioned on the front side and the back side of the holding member/effective composition raw material/peeling protective member laminate with the peeling protective member 23 interposed therebetween. , holding member 21 and respective cut cooled undeformed benefit composition material 22c are pressed against each other. During the process of raising the temperature to about 25° C. and at about 25° C., each cut-cooled non-deformed benefit composition raw material 22c changes into the form of a fluid benefit composition raw material 22a, and a part of each benefit composition raw material 22a is A state is formed in which they enter into the unevenness of the finely uneven surface of the holding member 21, and in this state, each active composition raw material is cross-linked and matured to change into each flexible beneficial composition 22 in a flexible state without fluidity. be done. In this way, the A1 softening composition 22 and the A2 softening composition 22 are bonded to each other and bonded to the holding member 21 without being peeled off to form a patch.

In the present embodiment, the aforementioned [Method effect A] and [Constitutional effect A] are obtained, and [Method effect D], [Method effect F], [Method effect C a], [Method effect G], [ Method effect key c], [method effect c], [method effect kuke], [method effect co-a], [method effect c], [method effect c], [method effect x], [ Composition effect d], [construction effect ku], [construction effect Kuke], [construction effect sa], [construction effect sa-a], [construction effect sa-b], [construction effect ka], [construction effect card a], [construction effect co-a], and other effects can be obtained.

(Typical Example 5-2)
A typical example of a method for manufacturing a patch-containing package containing multiple types of ingredients for a softening and efficacy composition will be described. This example relates to an adhesive patch containing package formed by laminating a plurality of types of cut cooling non-deforming effective composition raw materials cut in a cooled state in the stacking direction of the holding member.
It is similar to the exemplary embodiment 5-1 described above, and has the following configuration instead of a part of the configuration.

・[Step A: Fluid efficacy composition raw material preparation step/Predetermined shape forming step by cooling cutting]:
A water-containing gel-like A1 flow benefit composition raw material 22a having crosslinkability prepared in (Typical Example 1-1) is prepared. Separately, the crosslinkable water-containing gel-like A2 fluid efficacy composition raw material 22a prepared in (Typical Example 1-2) is prepared.
In a room temperature atmosphere of about 25° C., the hydrous gel-like A1 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 140 mm, a width of about 200 mm, and a height of about 2 mm or more to a thickness of about 2 mm. be put in.
Separately, in a room temperature atmosphere of about 25° C., the water-containing gel-like A2 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 140 mm, a width of about 200 mm, and a height of about 2 mm or more to a thickness of about 2 mm. be put in.
The A1 fluid benefit composition material 22a placed in the polystyrene container prepared above and the A2 fluid benefit composition material 22a placed in the polystyrene container were heated at a temperature of about -10 to about 3°C. cooling to a second cooling undeformed temperature to an undeformed state to form an A1 cooled undeformed benefit composition stock in an undeformed state and an A2 cooled undeformed benefit composition stock in an undeformed state followed by A1 cooling; The non-deformed benefit composition raw material 22b and the A2 cooled non-deformed benefit composition raw material are cut into a plurality of A1 cut cooled non-deformed benefit compositions of a predetermined shape (approximately 140 mm in length, approximately 70 mm in width, and approximately 2 mm in height). Raw material 22c and A2 cut chilled undeformed benefit composition raw material 22c are prepared.

・ [B process: Lamination member lamination process]:
A holding member 21 made of a needle-punched nonwoven fabric having bending flexibility, stretchability, and air humidity permeability and having a thickness of about 1 mm, a vertical width of about 150 mm, and a horizontal width of about 80 mm, containing polyethylene terephthalate fibers, other fibers, binders, etc. prepare. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Separately, a peeling protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 150 mm, and a width of about 80 mm is prepared.
In a room temperature atmosphere of about 25° C., as shown in FIG. 7, the A1 cut and cooled prepared in the above step (A) in a state in which a holding member peripheral margin 21a of about 5 mm is formed on the surface of the holding member 21. The non-deformed benefit composition raw material 22c and the A2-cut cooled non-deformed benefit composition raw material 22c are stacked in the stacking direction on the surface of the holding member 21, and these A1-cut cooled non-deformed benefit composition raw material 22c and A2 are laminated. The peel protective member 23 is laminated so as to cover the cut and cooled non-deformed effective composition raw material 22c and the holding member peripheral margin 21a, thereby preparing a holding member/effective composition raw material/peeling protective member laminate.

・ [Step C: Laminate packaging step]:
By the same method as in Typical Example 5-1 described above, the holding member/effective composition raw material/releasing member laminate is placed in a packaging container, and the packaging container holds the holding member/effectiveness. The opening of the packaging container is sealed so as to deform along the shape of the composition raw material/peeling member laminate so as to be in close contact with each other to prepare a laminate-accommodating package.

・ [Step D: Ripening step of ingredients for efficacy composition]:
By the same method as in Exemplary Embodiment 5-1 described above, the flowing benefit composition material located on the surface of the retaining member is joined to the retaining member and the respective flowing benefit composition ingredients are joined together to form a flowing Aging step of aging and changing each softening composition in a flexible state without elasticity to prepare a holding member/softening composition/peeling protective member laminate in which the softening composition is adhered and bonded to the holding member. As a result, a patch comprising a holding member, a flexible composition, and a peeling protective member having a changed configuration is formed by maturing each active composition raw material into a flexible composition having no fluidity. , a patch containing packaged product is obtained in which the patch is housed in the packaging container.
In this way, a patch containing package containing a patch having a size of about 150 mm in length and about 80 mm in width is obtained.

In the present embodiment, the above-mentioned [Method effect A] and [Constructive effect A] are obtained, and [Method effect D], [Method effect F], [Method effect car b], [Method effect G], [ Method effect key c], [method effect c], [method effect kuke], [method effect co-a], [method effect c], [method effect c], [composition effect D], [composition effect ], [Composition Effect Kuke], [Composition Effect Sa], [Composition Effect Sa-a], [Composition Effect Sa-b], [Composition Effect Ka], [Composition Effect Car-b], [Composition Effect Co- a], etc. can be obtained.

(Typical Example 5-3)
Another typical embodiment relating to the method of manufacturing a patch containing package containing a plurality of types of ingredients for a flexible efficacy composition will be described. This example relates to an adhesive patch storage package formed by laminating multiple types of fluid efficacy composition raw materials in the planar direction of a holding member.
It is similar to Exemplary Embodiment 5 described above, and has the following configuration instead of some configurations.

・[Step A: Fluid efficacy composition raw material preparation step]:
A water-containing gel-like crosslinkable A1 flow benefit composition raw material 22a prepared in (Typical Example 1-1) is prepared. Separately, the crosslinkable water-containing gel-like A2 fluid efficacy composition raw material 22a prepared in (Typical Example 1-2) is prepared.

[Step B: Laminating member laminating step: Holding member/effective composition raw material/peeling protective member laminating step]:
A holding member 21 made of a needle-punched nonwoven fabric having bending flexibility, stretchability, and air humidity permeability and having a thickness of about 1 mm, a vertical width of about 110 mm, and a horizontal width of about 150 mm, containing polyethylene terephthalate fibers, other fibers, binders, etc. prepare. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Separately, a peel protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 110 mm, and a width of about 150 mm is prepared.
In an atmosphere of room temperature of about 25° C., the A1 fluid efficacy composition raw material 22a and the A2 fluid efficacy composition raw material 22a prepared by the above step A are combined in a state of forming a holding member peripheral blank portion 21a of about 5 mm on the surface of the holding member 21. Within about 20 minutes after the preparation of these fluid efficacy composition raw materials, the material raw material 22a was formed into a shape having a thickness of about 2 mm, a vertical width of about 100 mm, and a horizontal width of about 35 mm, as shown in FIG. 9(C). While alternately adhering to and layering on the planar region of the peeling protective member 23, the peeling protective member 23 is laminated in such a manner as to cover the fluid efficacy composition raw material 22a and the holding member peripheral margin 21a, and thus the holding member. • Prepare the benefit composition raw material/peel protection member laminate.
In this step, a plastic frame having a vertical width of about 100 mm and a horizontal width of about 35 mm is placed inside the holding member peripheral margin 21a on the surface of the holding member 21, and a fluid gel-like substance is placed inside the frame. Two A1 flows having a thickness of about 2 mm, a vertical width of about 100 mm, and a horizontal width of about 35 mm so as to form a holding member peripheral blank portion 21 a by charging each of the flowing effect composition raw materials 22 a. The beneficial composition raw material 22 a and the A2 flowing beneficial composition raw material 22 a are laminated on the surface of the holding member 21 .

・ [Step C: Laminate packaging step]:
By the same method as in Typical Example 5-1 described above, the holding member/effective composition raw material/releasing member laminate is placed in a packaging container, and the packaging container holds the holding member/effectiveness. The opening of the packaging container is sealed so as to deform along the shape of the composition raw material/peeling member laminate so as to be in close contact with each other to prepare a laminate-accommodating package. Here, each of the flow benefit composition ingredients has a predetermined shape and maintains fluidity.

・ [D step: aging step]:
By the same method as in exemplary embodiment 5-1 described above, each of the flowing benefit composition ingredients located on the surface of the holding member is joined to the holding member and each of the flowing benefit composition ingredients is joined to each other. , aging and changing each softening composition in a soft state without fluidity to prepare a holding member/softening composition/peeling protective member laminate in which the softening composition is adhered and bonded to the holding member; . As a result, a patch having a holding member, a flexible composition, and a peeling protection member having a changed configuration is formed by maturing each fluid composition raw material into a non-fluid, flexible composition. , a patch-containing packaged product is obtained in which the patch is housed in the packaging container;
In this way, a patch containing package containing a patch having a size of about 110 mm in length and about 150 mm in width is obtained.

In the present embodiment, the aforementioned [Method effect A] and [Constitutional effect A] are obtained, and [Method effect B], [Method effect F], [Method effect C a], [Method effect C], [ Method Effect Kuke], [Method Effect C-a], [Method Effect C-a], [Method Effect C-b], [Composition Effect C], [Composition Effect Cuke], [Composition Effect C], [Composition Effect [S-a] [Synthesis effect power], [Structure effect power-a], [Structure effect power-a], etc. can be obtained.

(Exemplary Examples 5-4)
Another typical embodiment relating to the method of manufacturing a patch containing package containing a plurality of types of ingredients for a flexible efficacy composition will be described.
This example relates to an adhesive patch storage package formed by laminating a plurality of types of cooling non-deforming effective composition raw materials in the planar direction of a holding member.
It is similar to the exemplary embodiment 5-1 described above, and has the following configuration instead of a part of the configuration.

・[Step A: Fluid effective composition raw material preparation step/Predetermined shape forming step by cooling]:
A water-containing gel-like crosslinkable A1 flow benefit composition raw material 22a prepared in (Typical Example 1-1) is prepared. Separately, the crosslinkable water-containing gel-like A2 fluid efficacy composition raw material 22a prepared in (Typical Example 1-2) is prepared.
The above water-containing gel-like A1 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 140 mm, a width of about 70 mm, and a height of about 2 mm or more in a room temperature atmosphere of about 25° C. to a thickness of about 2 mm. be put in.
Separately, the above water-containing gel-like A2 fluid efficacy composition raw material 22a was placed in a room temperature atmosphere of about 25° C. in a polystyrene container having a length of about 140 mm, a width of about 70 mm, and a height of about 2 mm or more. Throw in so that it becomes 2 mm.
The A1 fluid benefit composition material 22a placed in the polystyrene container prepared above and the A2 fluid benefit composition material 22a placed in the polystyrene container were heated at a temperature of about -10 to about 3°C. Cooling to a second cooled undeformed temperature to an undeformed state to form an A1 cooled undeformed benefit composition stock in an undeformed state and an A2 cooled undeformed benefit composition stock in an undeformed state.

・ [B process: Lamination member lamination process]:
The non-deformable cooling effect composition raw material and the peeling protective member are laminated on predetermined positions on the surface of the holding member with the peeling protective member positioned on the surface side to form the holding member/effective composition raw material/ A peel protection member laminate is prepared. Here, each of the cooled non-deformable effective composition raw materials is laminated at positions overlapping each other in the lamination direction of the holding member.

・ [Step C: Laminate packaging step]:
By the same method as in Typical Example 5-1 described above, the holding member/effective composition raw material/releasing member laminate is placed in a packaging container, and the packaging container holds the holding member/effectiveness. The opening of the packaging container is sealed so as to deform along the shape of the composition raw material/peeling member laminate so as to be brought into close contact with each other to prepare a laminate-accommodating package.

・ [Step D: Ripening step of ingredients for efficacy composition]:
By the same method as in exemplary embodiment 5-1 described above, the benefit composition ingredients located on the surface of the holding member are joined to the holding member, and the respective benefit composition ingredients are joined to each other to form a flowable material. a maturing step of aging and changing each softening composition in a flexible state to prepare a holding member-softening composition-peeling protective member laminate in which the softening composition is adhered and bonded to the holding member; to form a patch comprising a holding member, a softening composition, and a peeling protection member, each of which has a configuration changed by maturing each active composition raw material into each softening composition having no fluidity, and A patch-containing package is obtained in which the patch is housed in the packaging container.
In this way, a patch containing package containing a patch having a size of about 150 mm in length and about 80 mm in width is obtained.

In this embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect C], [Method Effect G], [Method Effect Key-a], [Method Effect Q], [ Method Effect Kuke], [Method Effect C-a], [Method Effect C], [Construction Effect C], [Construction Effect C], [Construction Effect Kuke], [Construction Effect S], [Construction Effect C-a] , [construction effect power], [construction effect car-b], [construction effect co-a], etc. are obtained.

Further, in the above typical examples 5-2, 5-3, and 5-4, due to the pressure difference between the inside and outside of the packaging container, the surface of the nonwoven fabric holding member 21 having a finely uneven surface The adhering A1 softening composition 22 and/or A2 softening composition 22 are bonded to each other and enter into the fine irregularities on the surface of the holding member 21 made of nonwoven fabric. A patch is formed by bonding the object 22 to the holding member 21 without peeling off.

(Comparative Example 5a)
In the exemplary embodiment 5-3, each step is replaced by the following steps which are partially similar to the conventional manufacturing steps shown in FIG.
- [step similar to step (a) in FIG. 12]:
In a room temperature atmosphere of about 25° C., the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in the above (Typical Example 1-1) was measured in a vertical width of about 40 mm and a horizontal width of about 110 mm. It is put into a polystyrene container with a height of about 2 mm or more so that the thickness becomes about 2 mm.
Separately, in an atmosphere of room temperature of about 25° C., the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-2) was spread to a length of about 40 mm and a width of about It is put into a polystyrene container having a size of 110 mm and a height of about 2 mm or more so as to have a thickness of about 2 mm.

・[Step similar to step (b-a) in FIG. 12]:
A holding member 21 made of a needle-punched nonwoven fabric having bending flexibility, stretchability, and air humidity permeability and having a thickness of about 1 mm, a vertical width of about 110 mm, and a horizontal width of about 150 mm, containing polyethylene terephthalate fibers, other fibers, binders, etc. prepare. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Separately, a peel protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 110 mm, and a width of about 150 mm is prepared.
In an atmosphere of room temperature of about 25° C., the A1 fluid efficacy composition raw material 22a and the A2 fluid efficacy composition raw material prepared by the above-described steps are combined in a state in which a holding member peripheral blank portion 21a of approximately 5 mm is formed on the surface of the holding member 21. Within about 20 minutes after the preparation of these fluid efficacy composition raw materials, 22a was formed into a shape having a thickness of about 2 mm, a length of about 100 mm, and a width of about 35 mm, as shown in FIG. 9(C). While alternately adhering and layering on the planar region of the member 23, the peeling protection member 23 is layered in a state of covering the fluid efficacy composition raw material 22a and the holding member peripheral margin 21a. A composition raw material/peeling protective member laminate is prepared.

・ [Steps similar to FIG. 12 (b-c) step, (c-a) step]:
While being placed in an atmosphere of about 25° C., the A1 fluidizing effect composition raw material 22a and the A2 fluidizing effect composition raw material 22a are crosslinked to each of the flexible effect compositions 22 having no fluidity and aged. Each softening composition 22 is adhered and bonded to the holding member 21, and the holding member/softening composition/peeling protective member laminate in which each softening composition 22 is adhered and bonded to the holding member 21 is formed. Form. As a result, each fluid composition raw material 22a is matured into each softening composition 22 to form a patch 2 having a holding member, a softening composition, and a peeling protection member having a changed configuration.
Here, in the holding member, fluid efficacy composition raw material, and peeling protection member, as shown in FIG. has fluidity, the thickness H of the fluid efficacy composition raw material 22a is reduced to a thickness H2, and the fluid efficacy composition raw material 22a protrudes from the end face of the holding member 21 by a length of L2. become a state.
Then, as shown in FIG. 12(c-a), with the lapse of time, each of the fluid composition raw materials 22a is crosslinked from the fluid state to the non-fluid state of the flexible composition 22. Each softening composition 22 is adhered and bonded to the holding member while being aged and changed, and the holding member/softening composition/peeling protective member laminate in which each softening composition 22 is adhered and joined to the holding member is formed. A prepared patch is obtained. Here, the protruding fluid benefit composition raw material 22a is also aged and changed from the fluid state to the flexible benefit composition 22 having adhesiveness without fluidity.

・[step similar to step (d-a) in FIG. 12]:
A film-like packaging container 3 having a thickness of about 0.1 mm or less is prepared, which is the same as that used in Typical Example 5-3, and the above ( c-b) With the patch prepared in the step placed, the opening of the packaging container 3 in a region spaced apart by about 5 mm or more from the periphery of the patch is pressed and heated by a heat sealer, The opening of the packaging container 3 is fused and joined to be sealed. In this way, a patch-containing packaged product in which the patch is stored in the packaging container 3 is obtained. Here, the packaging container 3 is not housed in a state of being in close contact with the patch.

(Comparative Example 5b)
- [step similar to step (a) in FIG. 12]:
In a room temperature atmosphere of about 25° C., the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-1) was measured in a vertical width of about 140 mm and a horizontal width of about 70 mm. It is put into a polystyrene container with a height of about 2 mm or more so that the thickness is about 2 mm.
Separately, in an atmosphere of room temperature of about 25° C., the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-2) was cut into a strip with a length of about 140 mm and a width of about It is put into a polystyrene container having a size of 70 mm and a height of about 2 mm or more so as to have a thickness of about 2 mm.

・[Step similar to step (b-a) in FIG. 12]:
A holding member 21 made of a needle-punched nonwoven fabric having bending flexibility, stretchability, and air humidity permeability and having a thickness of about 1 mm, a vertical width of about 150 mm, and a horizontal width of about 80 mm, containing polyethylene terephthalate fibers, other fibers, binders, etc. to prepare. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Separately, a peeling protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 150 mm, and a width of about 80 mm is prepared.
In an atmosphere of room temperature of about 25° C., the A1 fluid efficacy composition raw material 22a and the A2 fluid efficacy composition raw material prepared by the above-described steps are combined in a state in which a holding member peripheral blank portion 21a of approximately 5 mm is formed on the surface of the holding member 21. Within about 20 minutes after the preparation of these fluid efficacy composition raw materials, each fluid efficacy composition raw material 22a is formed into a shape having a thickness of about 2 mm, a vertical width of about 140 mm, and a horizontal width of about 70 mm, and is peeled off as a protective member. 23 is adhered and laminated in the stacking direction, and the peeling protection member 23 is laminated in such a state that it covers the flowing efficacy composition raw material 22a and the holding member peripheral margin 21a, and in this way the holding member/effective composition raw material • Prepare a release protection member laminate.

・ [Steps similar to FIG. 12 (b-c) step, (c-a) step]:
While being placed in an atmosphere of about 25° C., the A1 fluidizing effect composition raw material 22a and the A2 fluidizing effect composition raw material 22a are crosslinked to each of the flexible effect compositions 22 having no fluidity and aged. The softening composition 22 is adhered to the holding member 21, and the softening composition 22 is adhered and joined to the holding member 21. The holding member/softening composition/peeling protective member. Form a laminate. As a result, each fluid composition raw material 22a is matured into each softening composition 22 to form a patch 2 having a holding member, a softening composition, and a peeling protection member having a changed configuration.
Here, in the holding member, the fluid efficacy composition raw material, and the peeling protective member, similar to FIG. Due to the fluidity, the thickness H of the fluid efficacy composition raw material 22a is reduced to a thickness H2, and the fluid efficacy composition raw material 22a protrudes from the end surface of the holding member 21 by a length L2. become.
Then, as shown in FIG. 12(c-a), with the lapse of time, each of the fluid composition raw materials 22a is crosslinked from the fluid state to the non-fluid state of the flexible composition 22. Each softening composition 22 is adhered and bonded to the holding member while being aged and changed, and the holding member/softening composition/peeling protective member laminate in which each softening composition 22 is adhered and joined to the holding member is formed. A prepared patch is obtained. Here, the protruding fluid benefit composition raw material 22a is also aged and changed from the fluid state to the flexible benefit composition 22 having adhesiveness without fluidity.

・[step similar to step (d-a) in FIG. 12]:
A film-like packaging container 3 having a thickness of about 0.1 mm or less having the same laminate structure as the packaging container 3 used in Typical Example 5-3 is prepared, and two upper and lower film-like packaging containers are used. With the patch prepared by the above step (c-a) placed between the containers 3, the opening of the packaging container 3 in an area spaced apart by about 5 mm or more from the periphery of the patch is heat-sealed. By pressing and heating the opening of the packaging container 3, the opening is fused and welded to be sealed. In this way, a patch-containing packaged product in which the patch is stored in the packaging container 3 is obtained. Here, the packaging container 3 is not housed in a state of being in close contact with the patch.
In this way, a patch containing package containing a patch having a size of about 150 mm in length and about 80 mm in width is obtained.

In both of the patch containing packages of Comparative Example 5a and Comparative Example 5b, the softening and beneficial composition formed between the holding member and the peeling protective member was applied to the edge between the holding member and the peeling protective member. There is a tendency for a defective patch to be produced that protrudes from the part. When the adhesive patch that constitutes the protruding functional softening composition is placed in a packaging container, the protruding functional softening composition adheres to the inner surface of the packaging container, making it easy to remove the patch from the packaging container. There is an inconvenience that there is no Furthermore, when the patch is applied to the skin of the human body, the protruding composition for softening exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, and the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, there is a tendency that a portion of the back side of the holding member is sticky, giving an unpleasant feeling.

(Typical Example 6-1)
Description will be given of a patch-containing package that is housed in a heat-shrinkable packaging container that has the property of shrinking when heated.
By the same steps as in the above-described exemplary embodiment 2-1, [Step A: Fluid efficacy composition raw material preparation step] and [Step B: Lamination member lamination step: Holding member/fluid efficacy composition raw material/peeling protective member lamination Step] to prepare the holding member/effective composition raw material/peeling protective member laminate.

・ [C: Laminate packaging step] step:
As shown in FIG. 1(C), a heat-shrinkable package having heat-shrinkability to serve as a packaging container is placed both above and below the holding member/effective composition raw material/peeling member laminate. With the container sheets positioned, the laminate is positioned between the heat-shrinkable packaging container sheets, heated, and the openings of the packaging container sheets are sealed. As a result, a laminated product containing package is prepared in which the packaging container is brought into close contact with the shape of the holding member/effective composition raw material/peeling protective member laminate due to heat shrinkage. Here, the peel protection member 23 covers the surface and edges of the active composition raw material 22a and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in contact with the holding member and the active composition. It is possible to obtain a laminated product storage package that is deformed along the shape of the raw material/peeling protective member laminated product and is in close contact with the product.
A polyvinyl chloride film is used as a material for heat-shrinkable packaging containers.

[D: Effective composition raw material aging step] similar to Typical Example 2-1, the laminate containing package prepared in step (C) is placed in a room temperature atmosphere of about 25 ° C. for about 60 minutes or more. In the step of placing, while being placed in an atmosphere of about 25° C., the fluid efficacy composition raw material 22a constituting the laminate containing package is crosslinked to the flexible efficacy composition 22 in a flexible state without fluidity. While aging and changing, the softening composition 22 is adhered and bonded to the holding member 21 to form a holding member/softening composition/peeling protective member laminate in which the softening composition 22 is adhered and bonded to the holding member 21. do. As a result, the adhesive patch 2 provided with the holding member, the softening composition, and the peeling protection member, which has a configuration changed by maturing the fluid composition raw material 22a into the flexible composition 22 having stickiness and no fluidity. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

Here, the packaging container 3 is kept in close contact with the surface and edges of the fluid efficacy composition material 22a and the peripheral blank portion 21a of the holding member 21 via the peel protection member 23. 22a is crosslinked with a softening composition 22 to be aged, and the patch 2 comprising a holding member, a softening composition and a peel protection member laminate is stored in a packaging container 3. is obtained. That is, the peel protection member 23 covers the surface and edges of the flexible composition 22 and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in a state where the holding member and the flexible composition are in close contact. It is possible to obtain an adhesive patch storage package that is deformed along the shape of the object/peeling protective member laminate and adheres to the laminate. In particular, the softening composition 22 is adhered to the surface of the holding member 21 while forming the peripheral margin 21a of the holding member 21 without protruding from the surface of the holding member 21, thereby obtaining a patch containing package.

In the method for manufacturing the patch containing packaged product of this embodiment or the patch containing packaged product of this embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect B] and [Method Effect A] are obtained. Effect KE], [Method Effect KE], [Method Effect C-a], [Method Effect C-a], [Composition Effect B], [Composition Effect KE], [Composition Effect KE], [Composition Effect C-a ], [Construction effect c], [Construction effect c-a], etc. are obtained.

(Typical Example 6-2)
A method for producing an adhesive patch containing package, which is housed in a heat-shrinkable packaging container having the property of shrinking when heated, and which comprises a step of cooling and cutting an active composition raw material. A typical embodiment of is described.
By the same steps as in Typical Example 4-1 described above, [Step A: Flowable efficacy composition raw material preparation step and predetermined shape forming step by cooling cutting] and [Step B: Lamination member lamination step] to form a holding member and efficacy Preparation of composition raw material/peeling protective member laminate

・ [C: Laminate packaging step] step:
As shown in FIG. 3(C), heat-shrinkable packages having heat-shrinkability to serve as packaging containers are placed both above and below the holding member/effective composition raw material/peeling member laminate. With the container sheets positioned, the laminate is positioned between the heat-shrinkable packaging container sheets, heated, and the openings of the packaging container sheets are sealed. As a result, a laminated product containing package is prepared in which the packaging container is brought into close contact with the shape of the holding member/effective composition raw material/peeling protective member laminate due to heat shrinkage. Here, the peel protection member 23 covers the surface and edges of the active composition raw material and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in a state where the holding member/benefit composition is attached. It is possible to obtain a laminated product storage package that is deformed along the shape of the raw material/peeling protective member laminate and adheres thereto. Here, the cut-cooled undeformed benefit composition raw material remains undeformed.
A polyvinyl chloride film is used as a material for heat-shrinkable packaging containers.

In a step similar to that of Typical Example 4-1, [D: aging step of raw materials for efficacy composition], the laminate containing package prepared in step (C) was placed in an atmosphere of about 25°C. , The cut and cooled non-deformed benefit composition raw material 22c constituting the laminate storage package is crosslinked into the flexible benefit composition 22 in a flexible state without fluidity during the process of raising the temperature to about 25°C and at about 25°C. While being aged and changed, the softening composition 22 is adhered and bonded to the holding member 21 to form a holding member/softening composition/peeling protective member laminate in which the softening composition 22 is adhered and bonded to the holding member 21. be done. As a result, the cut-cooled non-deformable benefit composition raw material 22c is matured into the softening benefit composition 22 having stickiness and no fluidity, thereby providing a holding member, a softening benefit composition, and a peel protection member having changed configurations. A patch containing package 1 is obtained in which the patch 2 is formed and the patch 2 is housed in the packaging container 3 .
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

Here, the packaging container 3 is kept in close contact with the surface and edges of the cut and cooled non-deformed active composition raw material 22c and the peripheral margin 21a of the holding member 21 via the peel protection member 23. A patch containing package product in which the patch 2 having a holding member, a softening composition and a peel protection member laminate is stored in a packaging container 3. 1 is obtained. That is, the peel protection member 23 covers the surface and edges of the flexible composition 22 and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in a state where the holding member and the flexible composition are in close contact. It is possible to obtain an adhesive patch storage package that is deformed along the shape of the object/peeling protective member laminate and adheres to the laminate. In particular, the softening composition 22 is adhered to the surface of the holding member 21 while forming the peripheral margin 21a of the holding member 21 without protruding from the surface of the holding member 21, thereby obtaining a patch containing package.

In the method for manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and the aforementioned [Method Effect D] and [ Method effect ke], [Method effect ke], [Method effect ko-a], [Method effect si], [Method effect si-a], [Method effect si], [Method effect s], [Constitution effect d] , [Configuration effect], [Configuration effect Kuke], [Configuration effect Sa], [Configuration effect Sa-a], [Configuration effect Sa-b], [Configuration effect Ko], [Configuration effect Co-a], etc. A working effect is obtained.

In (Typical Example 6-1) and (Typical Example 6-2) [C: Laminate packaging step], as shown in FIG. The heat-shrinkable packaging container 3, 3c is filled with the holding member, the raw material of the effective composition, and the release member laminate, and the heat-shrinkable bag-like packaging container is heated to form a bag-like heat-shrinkable package. The openings of the containers 3, 3c are sealed. As a result, there is also a step of preparing a deformed laminate-accommodating package in which the packaging container is brought into close contact with the shape of the holding member/effective composition raw material/peeling protective member laminate due to heat shrinkage. It is possible.

(Comparative Example 6)
In the exemplary embodiment 6-1, the following steps partially similar to the conventional manufacturing steps shown in FIG. 12 are provided instead of the respective steps.
[step similar to step (a) in FIG. 12], [step similar to step (b-a) in FIG. 12], and [step (b-c) in FIG. step, (c-a) similar to step], the fluid efficacy composition raw material 22a is aged into the softening efficacy composition 22 to provide a holding member, a softening efficacy composition, and a peeling protection member having a changed configuration. A patch 2 is formed.
12 (b-c) step, step similar to (c-a) step], in the holding member/fluid effective composition raw material/peeling protective member, as shown in FIG. 12(b-c) , Since the fluid efficacy composition material 22a has fluidity until the fluid efficacy composition material 22a is crosslinked, the thickness H of the fluid efficacy composition material 22a decreases to the thickness H2, and the fluid efficacy composition The raw material 22a protrudes from the end surface of the holding member 21 by a protruding length L2.

Then, as shown in FIG. 12(c-a), with the lapse of time, the fluidizing effect composition raw material 22a is crosslinked from the fluid state to the softening effect composition 22 in a non-fluid state, and is aged and changed. At the same time, the softening composition 22 is adhered and bonded to the holding member to obtain a patch comprising a laminate of the retaining member, the softening composition and the peeling protective member in which the softening composition 22 is adhered and bonded to the holding member. Here, the protruding fluid benefit composition raw material 22a is also aged and changed from the fluid state to the flexible benefit composition 22 having adhesiveness without fluidity.

・[step similar to step (d-a) in FIG. 12]:
Prepare the same polyvinyl chloride film-like packaging container 3 as used in Typical Example 6-1, and between the upper and lower two film-like packaging containers 3, the above (c-i) ) With the patch prepared in step 1 placed thereon, the opening of the packaging container 3 in an area spaced apart by about 5 mm or more from the periphery of the patch is pressed and heated by a heat sealer to form a packaging container. The opening of 3 is welded and joined to seal. In this way, a patch-containing packaged product in which the patch is stored in the packaging container 3 is obtained. Here, the packaging container 3 is not housed in a state of being in close contact with the patch.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

In the patch containing package of Comparative Example 6, a patch was produced in which the softening composition formed between the holding member and the peeling protective member protruded from the edge between the holding member and the peeling protective member. There is a tendency for defects to occur. When the adhesive patch that constitutes the protruding functional softening composition is placed in a packaging container, the protruding functional softening composition adheres to the inner surface of the packaging container, making it easy to remove the patch from the packaging container. There is an inconvenience that there is no Furthermore, when the patch is applied to the skin of the human body, the protruding composition for softening exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, and the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, there is a tendency that a portion of the back side of the holding member is sticky, giving an unpleasant feeling.

(Exemplary Example 7)
A B1 fluid efficacy composition raw material 22a containing no cross-linking agent is prepared according to the following formulation.
Polyacrylic acid 2g, sodium polyacrylate neutralized product 5g, starch acrylic acid copolymer 2g, carboxymethyl cellulose 1g, carboxyvinyl polymer 1g, polyvinyl alcohol 3g, sorbitol 10g, menthol 0.1g, silica powder 1g, paraben 0. 1 g and a total of 100 g of water (the balance) are added and stirred while being heated to about 60 to 80° C. to prepare a fluid B1 fluid efficacy composition raw material 22a in which each component is uniformly mixed.
The B1 fluid efficacy composition raw material 22a thus prepared has a fluid state in which it can flow in a temperature range of about 50° C. or higher as the first fluid temperature, and about 3° C. as the second cooling non-deformation temperature. In the following temperature range, it becomes a cuttable non-deformed state, and in the temperature range of about 7° C. to about 30° C. as the third non-fluid temperature, it becomes a water-containing gel-like softening effect composition without fluidity. The softening composition that has become a water-containing gel-like softening composition without fluidity has a form that maintains non-fluidity without fluidity even when the temperature is raised to 40° C. or higher.

Using the B1 fluid efficacy composition raw material 22a thus prepared, a patch containing package is prepared by a method similar to that described above (Typical Example 4-1).
That is, instead of the A1 efficacy composition raw material in (Typical Example 4-1), the above B1 efficacy composition raw material is used, and similar to the above-described (Typical Example 4-1) [Step A : Flowing effect composition raw material preparation step and predetermined shape forming step by cooling cutting], [B step: laminated member laminating step], [C: laminated product packaging step] step, [D: effect composition raw material aging step] , to prepare a patch storage package.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

In the method for manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and the aforementioned [Method Effect D] and [ Method Effect C], [Method Effect Kuke], [Method Effect C-a], [Method Effect C-a], [Method Effect C-b], [Method Effect S], [Composition Effect D], [Construction Effect (H)], [Structure effect Kuke], [Structure effect c], [Structure effect C], [Structure effect C], etc. can be obtained.

(Exemplary Example 8)
In the aforementioned Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1, the following steps are provided in place of step (C) in each example.
[C: Laminate packaging step] step: As shown in FIG. A film-like packaging container 3 having a thickness of approximately 0.10 mm (thickness of approximately 100 μm) is prepared by bonding each layer with an adhesive having a thickness of several μm.
Other steps are the same as the above-described Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1.
This provides the same effect as the respective exemplary embodiment described above.

(Exemplary Example 9)
In the aforementioned Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1, the following steps are provided in place of step (C) in each example.
[C: Laminate packaging step] step: As shown in (C) of FIG. A film-like packaging container 3 having a thickness of approximately 0.07 mm (thickness of approximately 70 μm) is prepared by bonding each layer with an adhesive having a thickness of several μm.
Other steps are the same as the above-described Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1.
This provides the same effect as the respective exemplary embodiment described above.

According to the method for manufacturing a patch-containing package according to the present invention, a step of manufacturing a patch in which a holding member, a matured flexible active substance, and a peel-off protective member are laminated, and a step of storing the patch in a storage container. A patch that can form a patch having a softening effect composition that has been matured while being housed in a packaging container without going through both processes, and that contains the patch that has the matured softening effect composition As a result, it is possible to obtain the effect of being able to manufacture a package containing an adhesive patch that greatly simplifies the manufacturing process, improves mass productivity, and significantly reduces costs. be done.
In addition, since the emollient composition is aged in the packaging container, the time from the production of the patch to the packaging container is shortened, and as a result, the manufacturing process is improved. A patch that has stable quality by suppressing changes in composition and chemical deterioration due to deterioration and deterioration of ingredients due to evaporation and emission of ingredients contained in the softening composition in the inside and chemical reactions with air. can get.
Furthermore, in a state in which the packaging container is deformed along the shape of the holding member/effective composition raw material/peeling member laminate and brought into close contact, the fluid effective composition raw material having a flowable state does not have fluidity. Since the material is aged and changed into a flexible composition in a soft state, the shape of the raw material for the active composition during aging is maintained, and the raw material for the active composition is held between the holding member and the peeling protective member. Protrusion from between the member and the peel protection member is prevented. As a result, the sticking-out softening composition sticks to the inner surface of the packaging container, and the inconvenience of not being able to easily remove the patch from the packaging container is eliminated. Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use.

In the patch containing package of the present invention, the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch, and the softening composition is non-fluid. Evaporation of the ingredients contained in the softening composition or combination with air is achieved by a composition comprising a composition having a matured form aged in the form of a softening composition having a softening state that has been changed into a shape. It is possible to obtain an adhesive patch storage package having stable quality by suppressing changes in the composition of the contained components and chemical deterioration due to alteration and deterioration of the contained components due to chemical reactions. Furthermore, in order to provide a configuration in which the shape of the fluid efficacy composition raw material is maintained during aging, the space between the holding member for the fluid efficacy composition raw material and the peel protection member sandwiched between the holding member and the peel protection member. is prevented from escaping from the As a result, the sticking-out softening composition sticks to the inner surface of the packaging container, and the inconvenience of not being able to easily remove the patch from the packaging container is eliminated. Furthermore, when the patch is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side of the holding member is eliminated. , a patch storage package that can be used comfortably is obtained.

1 Patch containing package 2 Patch 21 Retaining member 21a Holding member peripheral margin 22 Softening effect composition, water-containing gel-like soft effect composition 22a Effective composition raw material, fluid effective composition raw material,
22b Effective composition raw material, cooled non-deformed effective composition raw material 22c Effective composition raw material, cut cooled non-deformed effective composition raw material 23 Peel protection member 3 Packaging container 3a Packaging container sealing portion 3c Heat-shrinkable packaging container

Claims (17)

(a) a sheet-shaped holding member, a softening composition adhered to and laminated on the holding member, and a sheet-shaped sheet laminated on the surface of the softening composition so as to be peelable during use. and (b) a packaging container containing the patch. It is taken out from the packaging container, the peel protective member is peeled off from the taken out patch, and the softening composition laminated and bonded to the holding member is applied to the skin of the human body for use. A method for manufacturing an adhesive patch storage package, comprising:
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
(A) a step of preparing an effective composition raw material;
(B) The effective composition raw material and the peel protection member are laminated on a predetermined position area on the surface of the holding member, with the peel protective member positioned on the surface side. A laminated member lamination step of preparing a member laminate,
Here, in a state in which the effective composition raw material is positioned in a region inside the periphery of the surface of the holding member to form a margin around the holding member on the surface of the holding member, the peeling protection member is attached to the effective composition. In a state of being located on the surface side of the raw material and the peripheral margin of the holding member,
Laminating the effective composition raw material and the peel protection member on the holding member,
(C) The holding member/effective composition raw material/release member laminate is placed in a packaging container, and the packaging container is formed into the shape of the holding member/effective composition raw material/release member laminate. A laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container so as to deform and adhere along the
Here, in a state in which the holding member/effective composition raw material/release member laminate is placed in a packaging container, the peel protection member covers the surface of the effective composition raw material and the holding member of the holding member. in close contact with the surrounding margins,
sealing the opening of the packaging container so that the packaging container deforms along the shape of the holding member/effective composition raw material/peeling member laminate and is brought into close contact;
as well as,
(D) maturing the active composition raw material constituting the laminate storage package into a soft active composition in a non-fluid state and adhering and joining the active flexible composition to the holding member to form the flexible active composition; an aging step of preparing a holding member/flexible benefit composition/peeling protective member laminate in which the benefit composition is adhered and bonded to the holding member;
Here, the peeling protection member covers and adheres to the surface and edges of the active composition raw material, and also covers and adheres to the surface of the margin around the holding member of the holding member. In a state in which the holding member is formed with a margin around the holding member without an object protruding from the surface of the holding member,
In a state in which the packaging container is deformed and adheres to the shape of the holding member/effective composition raw material/peeling member laminate,
The effect composition raw material is matured into a flexible effect composition having stickiness and flexibility without fluidity,
This will
Forming a patch comprising a holding member, a flexible composition, and a peeling protective member, wherein the ingredients of the composition are matured into a flexible composition having stickiness and a soft state without fluidity,
A patch-containing packaged product in which the patch is stored in the packaging container is obtained.
A method for manufacturing a patch containing package, comprising: (a) a sheet-shaped holding member, a softening composition adhered to and laminated on the holding member, and a sheet-shaped sheet laminated on the surface of the softening composition so as to be peelable during use. and (b) a packaging container containing the patch. It is taken out from the packaging container, the peel protective member is peeled off from the taken out patch, and the softening composition laminated and bonded to the holding member is applied to the skin of the human body for use. A method for manufacturing an adhesive patch storage package, comprising:
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch ,
The softening composition contains at least water and a water-soluble polymer,
The softening composition is made from a fluid composition raw material containing at least water and a water-soluble polymer, and gradually becomes sticky and flexible without fluidity over time. It has the property of being matured into a product,
(A) a step of preparing an effective composition raw material;
Here, the said benefit composition raw material is a fluid benefit composition raw material having a flowable fluid state,
(B) The fluidizing effect composition raw material and the peeling protective member are laminated on a predetermined position area on the surface of the holding member, with the peeling protective member positioned on the surface side. a lamination member lamination step for preparing a peel protection member laminate;
Here, the fluid efficacy composition raw material has fluidity,
the flow benefit composition raw material is located in an inner region than the periphery of the surface of the holding member,
In a state in which a margin around the holding member is formed on the surface of the holding member, and in a state in which the peel protection member is positioned on the surface side between the raw material for the fluid efficacy composition and the margin around the holding member,
Laminating the effective composition raw material and the peel protection member on the holding member,
(C) The holding member/effective composition raw material/release member laminate is placed in a packaging container, and the packaging container is formed into the shape of the holding member/effective composition raw material/release member laminate. A laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container so as to deform and adhere along the
Here, the fluid efficacy composition raw material has a predetermined shape and maintains fluidity,
With the holding member/beneficial composition raw material/releasable member laminate placed in a packaging container, the peeling protection member covers the surface of the flowing benefit composition raw material and the margin around the holding member of the holding member. in close contact with the
sealing the opening of the packaging container so that the packaging container deforms along the shape of the holding member/effective composition raw material/peeling member laminate and is brought into close contact;
as well as,
(D) aging the flowable composition raw material constituting the laminate housing package into a flexible composition in a non-fluid state, and adhering and bonding the flexible composition to the holding member to obtain a flexible composition; an aging step of preparing a holding member/flexible benefit composition/peeling protective member laminate in which the benefit composition is adhered and bonded to the holding member;
Here, in a state in which the peeling protection member covers and adheres to the surface and the edge of the fluid efficacy composition raw material and also covers and adheres to the surface of the margin around the holding member of the holding member,
In a state in which the holding member peripheral blank portion is formed on the holding member without the softening composition protruding from the surface of the holding member,
In a state in which the packaging container is deformed and adheres to the shape of the holding member/effective composition raw material/peeling member laminate,
The raw material for the fluid benefit composition is matured into a water-containing gel-like softening effect composition having stickiness and flexibility without fluidity,
This will
Forming a patch comprising a holding member, a flexible composition, and a peeling protective member, wherein the raw material of the fluid composition is matured into a flexible composition having stickiness and a flexible state without fluidity,
A patch-containing packaged product in which the patch is stored in the packaging container is obtained.
A method for manufacturing a patch containing package, comprising: (a) a sheet-shaped holding member, a softening composition adhered to and laminated on the holding member, and a sheet-shaped sheet laminated on the surface of the softening composition so as to be peelable during use. and (b) a packaging container containing the patch. It is taken out from the packaging container, the peel protective member is peeled off from the taken out patch, and the softening composition laminated and bonded to the holding member is applied to the skin of the human body for use. A method for manufacturing an adhesive patch storage package, comprising:
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening composition contains at least water and a water-soluble polymer,
The softening composition is made from a fluid composition raw material containing at least water and a water-soluble polymer. has the property of being matured into a softening effect composition of
The softening composition has a flowable state at a first flow temperature, a non-deformed state at a second cooling non-deformation temperature lower than the first flow temperature, and a second cooling At the third soft aging temperature, which is the non-deformation temperature, the non-flowable non-flowable form is changed to a sticky and flexible state,
The said benefit composition raw material is a cooled non-deforming benefit composition raw material that has been cooled to a second cooling non-deforming temperature,
(A) a step of preparing an effective composition raw material;
Here, the step of preparing the efficacy composition raw material is a fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a flowable state at the first flow temperature;
as well as,
a cooling predetermined shape forming step of cooling the flowing benefit composition raw material to a second cooling non-deformation temperature at which it is in a non-deformed state to prepare a cooled non-deformed effective composition raw material in a non-deformed state having a predetermined shape;
with
(B) The cooling non-deforming effect composition raw material and the peel protection member are laminated on a predetermined position area on the surface of the holding member with the peel protection member positioned on the surface side to form the holding member/effective composition raw material. - Lamination member lamination step of preparing a peel protection member laminate,
wherein the cooled non-deformed benefit composition raw material maintains a non-deformed state,
In a state where the non-deformable effect composition raw material for cooling is positioned inside the periphery of the surface of the holding member to form a holding member peripheral margin on the surface of the holding member, the peel protection member is attached to the non-cooling non-deformable composition. In a state of being located on the surface side of the transforming effect composition raw material and the peripheral margin of the holding member,
Laminating the cooling non-deformation effective composition raw material and the peel protection member on the holding member,
(C) The holding member/effective composition raw material/release member laminate is placed in a packaging container, and the packaging container is formed into the shape of the holding member/effective composition raw material/release member laminate. A laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container so as to deform and adhere along the
wherein the cooled non-deformed benefit composition raw material maintains a non-deformed state,
With the holding member/beneficial composition raw material/releasable member laminate placed in a packaging container, the peel protection member covers the surface of the cooled non-deformed effective composition raw material and the holding member of the holding member. in close contact with the surrounding margins,
sealing the opening of the packaging container so that the packaging container deforms along the shape of the holding member/effective composition raw material/peeling member laminate and is brought into close contact;
as well as,
(D) raising the temperature of the laminate containing package to a third soft aging temperature to ripen the cooled non-deformed benefit composition raw material into a flexible benefit composition in a flexible state without fluidity, and to mature the softening benefit composition; is adhered to the holding member to prepare a holding member/softening composition/peeling protective member laminate in which the softening composition is adhered and joined to the holding member;
Here, in a state in which the peel protection member covers and adheres to the surface and edges of the cooling non-deformable effective composition raw material and also covers and adheres to the surface of the margin around the holding member of the holding member,
In a state in which the holding member peripheral blank portion is formed on the holding member without the softening composition protruding from the surface of the holding member,
In a state in which the packaging container is deformed and adheres to the shape of the holding member/effective composition raw material/peeling member laminate,
The fluid effect composition raw material is matured into a flexible effect composition having stickiness and flexibility without fluidity,
This will
Forming a patch comprising a holding member, a flexible composition, and a peeling protective member, wherein the raw material of the fluid composition is matured into a flexible composition having stickiness and flexibility without fluidity,
A patch-containing packaged product in which the patch is stored in the packaging container is obtained.
A method for manufacturing a patch containing package, comprising: (a) a sheet-shaped holding member, a softening composition adhered to and laminated on the holding member, and a sheet-shaped sheet laminated on the surface of the softening composition so as to be peelable during use. and (b) a packaging container containing the patch. It is taken out from the packaging container, the peel protective member is peeled off from the taken out patch, and the softening composition laminated and bonded to the holding member is applied to the skin of the human body for use. A method for manufacturing an adhesive patch storage package, comprising:
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening effect composition comprises a plurality of types of softening effect compositions containing composition components different from each other,
Each softening composition of the plurality of types of softening compositions contains at least water and a water-soluble polymer,
Each of the plurality of types of softening compositions is made from a fluid composition raw material containing at least water and a water-soluble polymer, and gradually loses fluidity over time. It has the property of being matured into a water-containing gel-like softening composition having stickiness and flexibility,
(A) a step of preparing an effective composition raw material;
Here, the step of preparing the efficacy composition ingredients includes a fluid efficacy composition ingredient preparation step of preparing a plurality of types of fluid efficacy composition ingredients in a flowable state,
The efficacy composition raw material comprises a plurality of types of fluid efficacy composition raw materials having a flowable fluid state,
each of the plurality of types of fluid efficacy composition ingredients contains composition components different from each other,
(B) A holding member/benefit composition raw material is formed by laminating the respective flow benefit composition raw material and peel protection member on a predetermined position area on the surface of the holding member, with the peel protection member positioned on the surface side. - Lamination member lamination step of preparing a peel protection member laminate,
Here, each of the fluid efficacy composition raw materials has a predetermined shape and fluidity,
(i) each of the flowing benefit composition ingredients are stacked adjacent to each other on the planar region of the retaining member;
and/or
(ii) each of the fluid efficacy composition raw materials are stacked in positions overlapping each other in the stacking direction of the holding member;
The plurality of kinds of the flow benefit composition raw materials are positioned in a region inside the periphery of the surface of the holding member to form a holding member peripheral blank portion on the surface of the holding member, and the plurality of peel protection members are In a state where it is located on the surface side of the type of flowing efficacy composition raw material and the peripheral margin of the holding member,
laminating the plurality of types of fluid efficacy composition raw materials and a peel protection member on the holding member;
(C) The holding member/effective composition raw material/release member laminate is placed in a packaging container, and the packaging container is formed into the shape of the holding member/effective composition raw material/release member laminate. A laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container so as to deform and adhere along the
Here, each of the plurality of types of fluid efficacy composition ingredients has a predetermined shape and maintains fluidity,
In a state in which the holding member/beneficial composition raw material/releasable member laminate is positioned in a packaging container, the peeling protection member covers the surface of the plurality of types of flow benefit composition raw materials and holds the holding member. In a state in which it is in close contact with the margin around the member,
sealing the opening of the packaging container so that the packaging container deforms along the shape of the holding member/effective composition raw material/peeling member laminate and is brought into close contact;
as well as,
(D) Each of the fluid efficacy composition raw materials constituting the laminate-accommodating package is joined to the holding member and the respective fluid efficacy composition raw materials are joined to each other so that each of them is in a non-fluid, flexible state. The softening composition is aged and adhered to the holding member to prepare a holding member/softening composition/peeling protective member laminate in which the softening composition is adhered to the holding member. maturation process,
Here, in a state in which the peel protection member covers and adheres to the surfaces and edges of the plurality of kinds of the flow benefit composition raw materials, and also covers and adheres to the surface of the margin around the holding member of the holding member,
In a state in which the holding member peripheral margin is formed in the holding member without the plurality of types of flowable efficacy composition raw materials protruding from the surface of the holding member,
In a state in which the packaging container is deformed and adheres to the shape of the holding member/effective composition raw material/peeling member laminate,
The plurality of types of fluid efficacy composition raw materials are aged into a water-containing gel-like softening efficacy composition having stickiness and flexibility without fluidity ,
This will
Retaining member/softening effect composition/peeling having a structure in which each of a plurality of types of fluid effect composition raw materials is matured into a flexible effect composition in which each fluid effect composition raw material has adhesiveness without fluidity and a flexible state Forming a patch with a protective member,
A patch-containing packaged product in which the patch is stored in the packaging container is obtained.
A method for manufacturing a patch containing package, comprising: (a) a sheet-shaped holding member, a softening composition adhered to and laminated on the holding member, and a sheet-shaped sheet laminated on the surface of the softening composition so as to be peelable during use. and (b) a packaging container containing the patch. It is taken out from the packaging container, the peel protective member is peeled off from the taken out patch, and the softening composition laminated and bonded to the holding member is applied to the skin of the human body for use. A method for manufacturing an adhesive patch storage package, comprising:
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening composition contains at least water and a water-soluble polymer,
The softening effect composition is formed from a fluid effect composition raw material containing at least water and a water-soluble polymer, with the lapse of time, to form a water-containing gel that has stickiness and flexibility without fluidity. It has the property of being matured into a softening effect composition,
The softening effect composition comprises a plurality of types of softening effect compositions containing composition components different from each other,
Each of the plurality of types of softening compositions has a flowable state at the first flow temperature, and is not deformed at the second cooling non-deformation temperature, which is lower than the first flow temperature. It has a non-deformed state, and has a sticky and flexible state in which it is changed to a non-flowable form at the third soft aging temperature, which is the second cooling non-deformed temperature, and
(A) a step of preparing an effective composition raw material;
In this step, the step of preparing the ingredients for the efficacy composition is
a flow benefit composition raw material preparation step of preparing a plurality of types of flow benefit composition raw materials having a flowable state at a first flow temperature, wherein each of the plurality of types of flow benefit composition raw materials is a flow benefit composition; The raw materials contain different compositional components from each other,
as well as,
cooling each of the plurality of types of flow benefit composition ingredients to a second cooling non-deformation temperature at which each of the plurality of types of flow benefit composition ingredients is cooled to a non-deformed state, and each of the cooled non-deformed benefit composition ingredients in a non-deformed state having a predetermined shape; A cooling predetermined shape forming step to prepare the
with
(B) The cooling non-deformation effect composition raw material and the peel protection member are laminated on a predetermined position area on the surface of the holding member, with the peel protection member positioned on the surface side. Lamination member lamination step for preparing a raw material/peeling protective member laminate,
wherein each cooled undeformed benefit composition ingredient maintains an undeformed state;
(i) each chilled non-deforming benefit composition ingredient is laminated adjacent to one another in planar regions of the retaining member; and/or
(ii) each of the cooled non-deformable benefit composition raw materials are stacked in positions overlapping each other in the stacking direction of the holding member;
The plurality of types of cooling non-deformation effective composition raw materials are positioned in a region inside the periphery of the surface of the holding member to form a holding member peripheral margin on the surface of the holding member, and the peel protection member is In a state of being located on the surface side of the plurality of types of cooling non-deformable effective composition raw materials and the peripheral margin of the holding member,
laminating the plurality of types of cooling non-deformation effective composition raw materials and a peel protection member on the holding member;
(C) The holding member/effective composition raw material/release member laminate is placed in a packaging container, and the packaging container is formed into the shape of the holding member/effective composition raw material/release member laminate. A laminate packaging step of preparing a laminate-accommodating package by sealing the opening of the packaging container so as to deform and adhere along the
wherein each of the cooled non-deformed benefit composition ingredients of the plurality of types of cooled non-deformed benefit composition ingredients maintains a non-deformed state,
The holding member/effective composition raw material/releasable member laminate is placed in a packaging container, and the peel protection member covers the surface of the plurality of types of cooling non-deformable effective composition raw materials and the holding member. In a state in which it is in close contact with the margin around the holding member of
sealing the opening of the packaging container so that the packaging container deforms along the shape of the holding member/effective composition raw material/peeling member laminate and is brought into close contact;
as well as,
(D) joining each of the non-deforming cooling effect composition raw materials constituting the laminate containing package to the holding member and joining each of the cooling effect composition raw materials to each other to create a non-fluid, flexible state; A holding member/softening composition/peeling protection member laminate in which each softening composition is aged and the softening composition is adhered and bonded to the holding member, and the softening composition is adhered and bonded to the holding member. A maturation process to prepare the
Here, the peel protection member covers the surfaces and edges of the plurality of types of cooling non-deformable effective composition raw materials and adheres to them, and also covers and adheres to the surfaces of the holding member peripheral margins of the holding members. in,
In a state in which the packaging container is deformed and adheres to the shape of the holding member/effective composition raw material/peeling member laminate,
in a state in which the holding member peripheral blank portion is formed on the holding member without the plurality of kinds of cooling non-deforming effective composition raw materials protruding from the surface of the holding member,
In a state in which the packaging container is deformed and adheres to the shape of the holding member/effective composition raw material/peeling member laminate,
The plurality of types of cooling non-deforming effect composition raw materials are aged into a softening effect composition having stickiness and flexibility without fluidity,
This will
Retaining member/softening composition having a configuration in which each cooling composition raw material of a plurality of types of cooling non-deformation composition raw materials is matured into each softening composition having adhesiveness without fluidity and a flexible state. - A patch-containing package is obtained in which a patch having a peel protection member is formed and the patch is stored in the packaging container.
A method for manufacturing a patch containing package, comprising: The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
In the step (C),
The holding member/effective composition raw material/releasing member laminate is placed in a packaging container having flexibility to a degree that it can be deformed , and the inside of the packaging container is in a reduced pressure state lower than atmospheric pressure, A laminate packaging step of sealing the opening of the packaging container to prepare a laminate storage package in which the inside of the packaging container is formed in a reduced pressure state lower than atmospheric pressure,
Here, in a state in which the holding member/effective composition raw material/release member laminate is placed in a packaging container, the peel protection member covers the surface of the effective composition raw material and the holding member of the holding member. The opening of the packaging container is deformed along the shape of the holding member/effective composition raw material/peeling member laminate in a state of being in close contact with the peripheral margin so that the packaging container is in a state of being in close contact. to seal the
In the step (D),
The efficacy composition raw material constituting the laminate storage package is aged into a softening efficacy composition in a non-fluid state, and the softening efficacy composition is adhered and joined to the holding member to produce the softening efficacy composition. comprises an aging step of preparing a holding member/flexible benefit composition/peeling protective member laminate adhered and bonded to the holding member,
In a state in which the peel protection member covers and adheres to the surface and edges of the effective composition raw material and adheres to the margin around the holding member of the holding member,
In a state in which the holding member peripheral blank portion is formed on the holding member without the softening composition protruding from the surface of the holding member,
In a state in which the packaging container is deformed along the shape of the holding member/beneficial composition raw material/peeling member laminate due to the pressure difference between the inside and outside of the packaging container and is in close contact,
The effect composition raw material is matured into a flexible effect composition having stickiness and flexibility without fluidity,
As a result, the adhesive patch is deformed in such a manner that the packaging container comes into close contact with the shape of the holding member/effective composition raw material/peeling protective member laminate due to the pressure difference between the inside and the outside of the packaging container. You can get a storage package,
6. The method for manufacturing a patch containing package according to any one of claims 1 to 5 , characterized in that: The packaging container is a heat-shrinkable packaging container having flexibility to the extent that it can be deformed along the shape of the patch and having a property of shrinking when heated,
In the step (C),
The holding member/effective composition raw material/peeling member laminate is placed in a heat-shrinkable packaging container that has a deformable degree of flexibility and that shrinks when heated. In a state in which the raw material of the efficacy composition and the peel protective member laminate are placed in a heat-shrinkable packaging container, the heat-shrinkable packaging container is heat-shrunk by heating, and the heat-shrinkable packaging container is heat-shrinkable. A laminate packaging step of sealing the opening of the packaging container to prepare a laminate containing package ,
Here, the holding member/effective composition raw material/release member laminate is placed in a heat-shrinkable packaging container, and the peel protection member covers the surface of the effective composition raw material and the holding member. In a state in which the heat-shrinkable packaging container is in close contact with the margin around the holding member, the above sealing the opening of the heat-shrinkable packaging container,
In the step (D),
The efficacy composition raw material constituting the laminate storage package is aged into a softening efficacy composition in a non-fluid state, and the softening efficacy composition is adhered and joined to the holding member to produce the softening efficacy composition. comprises an aging step of preparing a holding member/flexible benefit composition/peeling protective member laminate adhered and bonded to the holding member ;
In a state in which the peel protection member covers and adheres to the surface and edges of the effective composition raw material and adheres to the margin around the holding member of the holding member,
In a state in which the holding member peripheral blank portion is formed on the holding member without the softening composition protruding from the surface of the holding member,
In a state in which the heat-shrinkable packaging container is shrunk by heat-shrinking action due to heating, deformed along the shape of the holding member/beneficial composition raw material/peeling member laminate, and adheres thereto,
The effect composition raw material is matured into a flexible effect composition having stickiness and flexibility without fluidity,
As a result, the heat-shrinkable packaging container is shrunk by the heat-shrinking action, and the heat-shrinkable packaging container comes into close contact along the shape of the holding member/effective composition raw material/peeling member laminate. A deformed patch storage package can be obtained by
6. The method for manufacturing a patch containing package according to any one of claims 1 to 5 , characterized in that: The packaging container is made of a material that melts and fuses when heated,
In the step (C),
The effective composition raw material is positioned inside the periphery of the surface of the holding member to form a margin around the holding member. In the state where it is laminated covering the surface of the peripheral margin,
In a state in which the holding member/effective composition raw material/peeling member laminate is positioned in a packaging container having flexibility to a degree that it can be deformed,
The opening of the packaging container is heated and pressed to fuse and seal the opening of the packaging container;
As a result, the adhesive patch is deformed in such a manner that the packaging container comes into close contact with the shape of the holding member/effective composition raw material/peeling protective member laminate due to the pressure difference between the inside and the outside of the packaging container. You can get a storage package,
7. The method of manufacturing a patch containing package according to claim 6 , wherein: The softening composition contains at least a water-soluble polymer and a cross-linking agent,
The water-soluble polymer includes at least polyacrylic acid, neutralized polyacrylic acid, partially neutralized polyacrylic acid, acrylic acid-methacrylic acid copolymer, carboxyalkyl cellulose, hydroxyalkyl cellulose, carboxyvinyl polymer, and , containing at least one crosslinkable water-soluble polymer selected from the group consisting of these salts,
In the step (D), the crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker, thereby maturing the active composition raw material into a soft active composition having no fluidity. A patch containing a patch containing a holding member and a softening composition having the above configuration is formed, and the patch is stored in the packaging container.
9. The method for manufacturing a patch containing package according to any one of claims 1 to 8, characterized in that: A patch and a packaging container containing the patch,
The adhesive patch includes a sheet-like holding member, a flexible composition having flexibility and being laminated by adhering and bonding to a predetermined position area on the surface of the holding member, and the surface of the softening composition. and a sheet-like peeling protective member laminated so as to be peelable at the time of use.
The emollient composition has adhesiveness, and when used, the patch is removed from the packaging container, the peel protection member is peeled from the removed patch, and the adhesive is laminated on the holding member. A patch storage package for use by attaching the bonded softening composition to the skin of a human body,
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The patch is housed and sealed in the packaging container in a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch. has the form of
The softening composition is positioned inside the periphery of the surface of the holding member to form a margin around the holding member, and the softening composition is laminated on the surface of the holding member. In addition, the peel protection member covers the softening composition and is formed in a form in close contact with the holding member peripheral margin of the holding member,
The packaging container is configured in a state of being in close contact along the shape of the patch,
The adhesive patch is formed by laminating the softening composition on the surface of the holding member in such a manner that the softening composition is positioned on the surface region of the holding member without protruding from the surface of the holding member, and a peeling protection member is in close contact with the margin around the holding member of the holding member and covers the surface and edges of the softening composition,
The softening composition has stickiness and a flexible state in a state in which the patch is positioned in the packaging container and the packaging container adheres along the shape of the patch. Having a matured form that is matured in the form of a product, comprising a configuration,
A patch storage package product characterized by: A patch and a packaging container containing the patch,
The adhesive patch includes a sheet-like holding member, a flexible composition having flexibility and being laminated by adhering and bonding to a predetermined position area on the surface of the holding member, and the surface of the softening composition. and a sheet-like peeling protective member laminated so as to be peelable at the time of use.
The emollient composition has adhesiveness, and when used, the patch is removed from the packaging container, the peel protection member is peeled from the removed patch, and the adhesive is laminated on the holding member. A patch storage package for use by attaching the bonded softening composition to the skin of a human body,
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The patch is housed and sealed in the packaging container in a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch. having the form
The softening composition has a matured form obtained by aging from the form of a fluid composition raw material having a fluid state to the form of a softening composition having a non-fluid state of flexibility,
The softening composition contains at least water and a water-soluble polymer,
The softening composition is made from a fluid composition raw material containing at least water and a water-soluble polymer. has the property of being matured into a softening effect composition of
The softening composition is positioned inside the periphery of the surface of the holding member to form a margin around the holding member, and the softening composition is laminated on the surface of the holding member. In addition, the peel protection member covers the softening composition and is formed in a form in close contact with the holding member peripheral margin of the holding member,
The packaging container is configured in a state of being in close contact along the shape of the patch,
The adhesive patch is formed by laminating the softening composition on the surface of the holding member in such a manner that the softening composition is positioned on the surface region of the holding member without protruding from the surface of the holding member, and a peeling protection member is in close contact with the margin around the holding member of the holding member and covers the surface and edges of the softening composition,
The softening composition has stickiness and a flexible state in a state in which the patch is positioned in the packaging container and the packaging container adheres along the shape of the patch. Having a matured form that is matured in the form of a product, comprising a configuration,
A patch storage package product characterized by: A patch and a packaging container containing the patch,
The adhesive patch includes a sheet-like holding member, a flexible composition having flexibility and being laminated by adhering and bonding to a predetermined position area on the surface of the holding member, and the surface of the softening composition. and a sheet-like peeling protective member laminated so as to be peelable at the time of use.
The emollient composition has adhesiveness, and when used, the patch is removed from the packaging container, the peel protection member is peeled from the removed patch, and the adhesive is laminated on the holding member. A patch storage package for use by attaching the bonded softening composition to the skin of a human body,
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The patch is housed and sealed in the packaging container in a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch. having the form
The softening composition has a matured form obtained by aging from the form of a fluid composition raw material having a fluid state to the form of a softening composition having a non-fluid state of flexibility,
The softening composition contains at least water and a water-soluble polymer,
The softening effect composition has the form of a fluid effect composition raw material that has a flowable state at a first flow temperature, and is non-deformable to the extent that it does not deform at a second cooling non-deformation temperature that is lower than the first flow temperature. It has the form of a cooled non-deformed efficacy composition raw material having a deformed state, and is changed to a non-flowable form without fluidity at the third softening aging temperature raised from the second cooling non-deformed temperature. Having the property of having an aged form obtained by aging in the form of an efficacy composition,
In a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch, the softening composition is in a non-deformed state at the second cooling non-deformation temperature. from the form having a matured form aged to the form of a softening effect composition having a flexible state that is changed to a non-fluid form having no fluidity at the third softening aging temperature serve,
The softening composition is positioned inside the periphery of the surface of the holding member to form a margin around the holding member, and the softening composition is laminated on the surface of the holding member. In addition, the peel protection member covers the softening composition and is formed in a form in close contact with the holding member peripheral margin of the holding member,
The packaging container is configured in a state of being in close contact along the shape of the patch,
The adhesive patch is formed by laminating the softening composition on the surface of the holding member in such a manner that the softening composition is positioned on the surface region of the holding member without protruding from the surface of the holding member, and a peeling protection member is in close contact with the margin around the holding member of the holding member and covers the surface and edges of the softening composition,
The softening composition has stickiness and a flexible state in a state in which the patch is positioned in the packaging container and the packaging container adheres along the shape of the patch. Having a matured form that is matured in the form of a product, comprising a configuration,
A patch storage package product characterized by: A patch and a packaging container containing the patch,
The adhesive patch includes a sheet-like holding member, a flexible composition having flexibility and being laminated by adhering and bonding to a predetermined position area on the surface of the holding member, and the surface of the softening composition. and a sheet-like peeling protective member laminated so as to be peelable at the time of use.
The softening composition has adhesiveness, and when used, the patch is removed from the packaging container, the peel protection member is peeled off from the removed patch, and the adhesive is laminated and bonded to the holding member. A patch storage package for use by attaching the softening composition obtained above to the skin of a human body,
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The patch is housed and sealed in the packaging container in a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch. having the form
The softening composition has a matured form obtained by aging from the form of a fluid composition raw material having a fluid state to the form of a softening composition having a non-fluid state of flexibility,
The softening composition contains at least water and a water-soluble polymer,
The softening composition is obtained from a fluid composition raw material containing at least water and a water-soluble polymer. It has the property of being aged to
The softening effect composition has a plurality of types of softening effect compositions containing composition components different from each other,
Each softening composition of the plurality of types of softening compositions has at least stickiness and exhibits different effects,
The adhesive patch includes a sheet-shaped holding member, a plurality of types of softening compositions arranged and bonded to predetermined positions on the surface of the holding member, and a laminate covering the surface of the softening composition. and a sheet-like peeling protection member,
(i) Each of the plurality of types of softening compositions has a predetermined shape, is arranged adjacent to each other on a planar region of the surface of the holding member, and is joined to each other. serve,
or
(ii) Each of the plurality of types of softening compositions has a predetermined shape, and is configured by being layered and arranged in a predetermined region on the surface of the holding member so as to overlap each other and joined to each other. become,
The softening composition is positioned inside the periphery of the surface of the holding member to form a margin around the holding member, and the softening composition is laminated on the surface of the holding member . In addition, the peel protection member covers the softening composition and is formed in a form in close contact with the holding member peripheral margin of the holding member,
The packaging container is configured in a state of being in close contact along the shape of the patch,
The adhesive patch is formed by laminating the softening composition on the surface of the holding member in such a manner that the softening composition is positioned on the surface region of the holding member without protruding from the surface of the holding member, and a peeling protection member is in close contact with the margin around the holding member of the holding member and covers the surface and edges of the softening composition,
The softening composition has stickiness and a flexible state in a state in which the patch is positioned in the packaging container and the packaging container adheres along the shape of the patch. Having a matured form that is matured in the form of a product, comprising a configuration,
A patch storage package product characterized by: A form in which the patch is housed and sealed in the packaging container in a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch,
The adhesive patch is placed in a packaging container, and the adhesive patch is housed and sealed in the packaging container in a reduced pressure state lower than the atmospheric pressure in the packaging container. ,
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening composition is positioned inside the periphery of the surface of the holding member to form a margin around the holding member, and the softening composition is laminated on the surface of the holding member. In addition, the peel protection member covers the softening composition and is formed in a form in close contact with the holding member peripheral margin of the holding member,
The packaging container is configured in a state of being in close contact along the shape of the patch,
The adhesive patch is formed by laminating the softening composition on the surface of the holding member in such a manner that the softening composition is positioned on the surface region of the holding member without protruding from the surface of the holding member, and a peeling protection member is in close contact with the margin around the holding member of the holding member and covers the surface and edges of the softening composition,
The softening composition has stickiness and a flexible state in a state in which the patch is positioned in the packaging container and the packaging container adheres along the shape of the patch. Having a matured form that is matured in the form of a product, comprising a configuration,
The adhesive patch storage package according to any one of claims 10 to 13, characterized in that: A form in which the patch is housed and sealed in the packaging container in a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch,
The packaging container is a heat-shrinkable packaging container having a property of shrinking when heated,
The patch is placed in a heat-shrinkable packaging container, and the patch is stored and sealed in the packaging container in a state in which the heat-shrinkable packaging container is thermally shrunk by heating. in the form of
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening composition is positioned inside the periphery of the surface of the holding member to form a margin around the holding member, and the softening composition is laminated on the surface of the holding member. In addition, the peel protection member covers the softening composition and is formed in a form in close contact with the holding member peripheral margin of the holding member ,
The packaging container is configured in a state of being in close contact along the shape of the patch,
The adhesive patch is formed by laminating the softening composition on the surface of the holding member in such a manner that the softening composition is positioned on the surface region of the holding member without protruding from the surface of the holding member, and a peeling protection member is in close contact with the margin around the holding member of the holding member and covers the surface and edges of the softening composition,
The softening composition has stickiness and a flexible state in a state in which the patch is positioned in the packaging container and the packaging container adheres along the shape of the patch. Having a matured form that is matured in the form of a product, comprising a configuration,
The adhesive patch storage package according to any one of claims 10 to 13, characterized in that: The softening effect composition further contains a medicinal ingredient,
The peeling protection member of the patch taken out from the packaging container is peeled from the softening composition, and the softening composition laminated and bonded to the holding member is applied to the human skin for use. When the softening effect composition has a cooling effect and/or a medicinal effect due to the medicinal ingredient contained in the softening effect composition,
The adhesive patch storage package according to any one of claims 10 to 15, characterized in that: The softening composition contains at least the water-soluble polymer and a cross-linking agent,
The water-soluble polymer includes at least polyacrylic acid, neutralized polyacrylic acid, partially neutralized polyacrylic acid, acrylic acid-methacrylic acid copolymer, carboxyalkyl cellulose, hydroxyalkyl cellulose, carboxyvinyl polymer, and containing at least one crosslinkable water-soluble polymer selected from the group consisting of these salts,
The softening effect composition is formed from a fluid effect composition raw material containing at least water and a water-soluble polymer, and then, with the lapse of time, a non-fluid, sticky and flexible water-containing gel-like composition. Having the property of being matured into a softening composition,
The patch storage package according to any one of claims 9 to 16, characterized in that:

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