JP7220850B2 - Method for manufacturing patch containing packaged product, and patch containing packaged product - Google Patents

Description

Detailed description of the invention

TECHNICAL FIELD The present invention relates to an adhesive patch package that is packaged with an adhesive patch that, when applied to the human body, exhibits effects such as a cooling effect, a warming effect, a cooling effect, an analgesic effect, an anti-inflammatory effect, or other pharmacological effects. .

Various cooling patches comprising a water-containing gel composition mainly containing a water-containing water-soluble polymer as a cooling material to be applied to the human body, which is excellent in portability and stickability, instead of ice pillows and ice bags for heat generation in the human body. agents have been proposed.
In addition, a water-containing gel composition containing a water-containing water-soluble polymer contains medicinal ingredients such as an analgesic ingredient and an anti-inflammatory ingredient. Various medicinal patches have been proposed.
In addition, non-aqueous compositions containing no water, non-aqueous elastic compositions having elasticity such as synthetic rubber, natural rubber, etc., containing medicinal ingredients such as analgesic ingredients and anti-inflammatory ingredients, can be applied transdermally to the human body. Various medicinal patches have been proposed that act to produce effects corresponding to their medicinal ingredients.

For example, Japanese Patent Application Laid-Open No. 2000-107219 (Patent Document 1) discloses a water-retaining matrix made of a water-soluble polymer and containing 40% by weight or more of water, and a water-retaining matrix dispersed and retained in the water-retaining matrix. A cold-retaining/moisturizing gel comprising fibers having at least a hydrophilic surface, at least a portion of which is exposed on the surface of the water-retaining matrix, and retaining a large amount of water in the water-retaining matrix. In addition, the fibers allow moisture to easily move within the base material, and these fibers facilitate volatilization of moisture from the water-retaining base material to the outside, resulting in excellent cold-retaining ability. is disclosed.

Japanese Patent Application Laid-Open No. 2004-298474 (Patent Document 2) discloses that (A) polyacrylic acid and/or a salt thereof, (A) polyacrylic acid and/or a salt thereof, ( B) A patch coated with a water-containing gel containing a cross-linking agent, which exerts an excellent acupressure effect and provides high blood flow improvement and therapeutic effects in the affected area. In addition, it is disclosed that the hydrous gel layer having flexibility and elasticity acts as a cushion and does not cause sharp pains caused by projections, thereby providing a comfortable feeling of use for a long period of time.

Japanese Patent Application Laid-Open No. 2004-231577 (Patent Document 3) discloses that functional components such as aromatic oils and pharmacologically active substances are carried in a water-retaining gel containing at least a water-soluble polymer, water, and a functional component and then slowly released. When a pad material in which gel particles are dispersed and using a water-retaining gel is continuously applied to the human body, the substantial sensory effect and sensory effect of the pad material gradually decrease. It is disclosed that the effect of suppressing this and exhibiting a sufficient sensory effect over a long period of time.

Japanese Unexamined Patent Application Publication No. 2003-183156 (Patent Document 4) describes an external patch comprising a support provided with a base layer, wherein the base composition forming the base layer contains a non-aqueous base, indomethacin and the like. It is disclosed that the patch for external use contains a medicinal ingredient and polyethylene glycol, and exhibits the effect of suppressing skin disorders while maintaining good adhesiveness, feeling of use, etc. of the patch.

Retable No. 2001-47559 (Patent Document 5) discloses an external patch having a support and a drug-retaining layer coated on the support, wherein the drug-retaining layer comprises a water-soluble polymeric substance. , a cross-linking agent, water, and a water-retaining agent as essential ingredients in an adhesive gel base, and tetracaine, procaine, dibucaine, lidocaine, benzocaine, xylocaine, or a pharmaceutically acceptable salt compound thereof as a medicinal ingredient. and a nonsteroidal anti-inflammatory analgesic consisting of ketoprofen, piroxicam, felbinac, bufexamac, suprofen, flurbiprofen, diclofenac, ibuprofen, or a pharmaceutically acceptable salt compound thereof. An external patch comprising a carrier, the external patch being an analgesic agent for pain associated with inflammation selected from the group consisting of rheumatoid arthritis, osteoarthritis, and lumbago, wherein the external patch comprises a chronic joint It has been disclosed that it can improve the analgesic effect of pain associated with inflammation such as rheumatoid arthritis, osteoarthritis, and lumbago.

Japanese Patent Application Laid-Open No. 2001-64161 (Patent Document 6) discloses a patch consisting of a backing part and an adhesive part, which has an adhesive part and contains indomethacin, ketoprofen, flurbiprofen, felbinac, diclofenac, or cromoglyc. It is a patch containing a poorly water-soluble drug such as an acid, which causes peeling and curling. It is disclosed that it exhibits excellent usability without remaining on the skin surface.

JP-A-2000-107219 JP 2004-298474 A JP 2004-231577 A JP-A-2003-183156 Retable 2001-47559 Japanese Patent Application Laid-Open No. 2001-64161

In the above-described conventional patches and patch-containing packages in which the patches are accommodated in a packaging container, the surface of the sheet-shaped holding member is generally coated with a raw material for a hydrous gel composition, a raw material for a plaster composition, or the like. A functional composition raw material in a fluid state is laminated, a peeling protection member is further laminated on the surface of the functional composition raw material in a fluid state, and then the functional composition raw material in a fluid state out of the laminated laminate is laminated. A patch is produced by a method including a aging treatment step of aging to a soft state to the extent that it does not flow and processing it into a softening composition, and then further laminated on the surface of the holding member and aged to a soft state. A method of producing a patch containing package by storing the patch composed of a softening composition and a peeling protective member in a packaging container capable of suppressing moisture and air permeation and sealing the packaging container. , patch storage packages are manufactured.

An example of a conventional method for manufacturing a general adhesive patch containing package will be described below.
9 and 10 are schematic process diagrams illustrating an example of the manufacturing process of a conventional method for manufacturing a patch containing packaged product.
In FIG. 10, an example of a method for manufacturing a conventional patch containing package product is manufactured by the following steps.
(a) Step: Fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material 22a having a fluid state capable of flowing at the first flow temperature.
(b) Step: On a predetermined position area of the surface of the holding member 21, the fluid efficacy composition raw material 22a and the peeling protective member 23 are laminated with the peeling protective member 23 positioned on the surface side. Peeling protection member lamination step for preparing a fluid efficacy composition raw material/peeling protection member laminate.
(c) Step: The holding member/fluid effect composition raw material/peeling protection member laminate is placed in an atmosphere at a third non-fluid softening temperature, and the fluid effect composition raw material 22a is changed from a fluid state to a non-fluid soft state. The softening composition 22 is aged and changed, and the softening composition 22 is adhered and bonded to the holding member, and the holding member, the softening composition, and the peel protection member lamination in which the softening composition 22 is adhered and bonded to the holding member. A patch containing a patch comprising a holding member, a softening composition, and a peeling protection member having a configuration in which the fluid composition raw material 22a is aged into the softening composition 22 by this aging step of preparing the product. 2 is obtained.
(d) Step: Sealing the opening of the packaging container 3 with the patch 2 positioned in the packaging container 3 to form the packaging container sealing portion 3a. As a result, a patch storage package containing the patch 2 is obtained.

In FIG. 9, an example of a conventional manufacturing method for a patch containing packaged product is manufactured by the following steps.
(a) Step: Fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material 22a having a fluid state capable of flowing at the first flow temperature.
(b-a) step: The fluidizing composition raw material 22a and the peel protection member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peel protection member 23 positioned on the surface side, and held. A release protection member lamination step for preparing a member/flow effect composition raw material/peeling protection member laminate, in which the flow effect composition raw material 22a is laminated so as to be located inside the peripheral portion of the surface of the holding member 21. .
In place of the (b-a) step, the (b-b) step: the fluid efficacy composition raw material 22a and the peeling protection member 23 are placed in a predetermined position area on the surface of the holding member 21, and the peeling protection member 23 is on the surface side. A peeling protective member lamination step for preparing a holding member/fluid efficacy composition raw material/peeling protective member laminate by laminating in a state where the are stacked so that they are positioned at the same position as
(b-c) step: After the step (b-a) or (b-b), as the time elapses, the fluid efficacy composition raw material 22a becomes more fluid, so that the fluid efficacy composition raw material 22a As the thickness H decreases to a thickness H2, the flow benefit composition raw material 22a protrudes from the end face of the holding member 21 by a protruding length L2.
Alternatively, step (b-d): after the step (b-a) or (b-b), the fluid efficacy composition raw material 22a becomes more fluid with the passage of time. As the thickness H of 22a decreases to a thickness H2, the fluid efficacy composition raw material 22a protrudes from the end surface of the holding member 21 and flows in the direction of the end surface of the holding member to a length of L2 and flows out. Become.

(c-a) step: In the state of (b-c) step, the holding member/flowing effect composition raw material/peeling protective member laminate is heated to the same temperature as the first flowing temperature or the third non-flowing softening temperature. The fluidizing composition raw material 22a is aged from the fluid state to the softening composition 22 having no fluidity in the atmosphere of , and the softening composition 22 is adhered and joined to the holding member to form the softening composition. 22 is adhered and bonded to the holding member, the aging step of preparing the laminate of the softening effect composition and the peeling protection member, whereby the fluidizing effect composition raw material 22a is aged into the softening effect composition 22. A patch 2 containing a patch provided with a member, a softening composition, and a peeling protective member is obtained. Here, the protruding fluid benefit composition raw material 22a is also matured from the fluid state to the flexible benefit composition 22 having stickiness without fluidity.
Alternatively, (c-b) step: in the state of step (b-d), the holding member/flowing effect composition raw material/peeling protective member laminate is heated to the same temperature as the first flow temperature, or to a third non-flowing In an atmosphere at the softening temperature, the fluidizing composition raw material 22a is aged from the fluid state to the softening composition 22 in the non-fluid state, and the softening composition 22 is adhered and joined to the holding member to provide the softening effect. A maturing step of preparing a holding member/softening effect composition/peeling protective member laminate in which the composition 22 is adhered and bonded to the holding member, whereby the flowing benefit composition raw material 22a is aged into the softening benefit composition 22. A patch 2 containing a patch having a holding member, a softening composition, and a peeling protection member is obtained. At this point, the fluidizing effect composition material 22a, which protrudes and adheres to the end surface of the holding member, is also matured from the fluid state to the flexible effect composition 22 having stickiness without fluidity.

(d-b) Step: The opening of the packaging container 3 is sealed while the patch 2 is positioned in the packaging container 3, whereby a patch containing package containing the patch 2 is obtained. be done. Here, the softening effect composition 22 in the softening state having the protruding stickiness without fluidity maintains the matured state.
or (d-b) step: the opening of the packaging container 3 is sealed while the patch 2 is positioned in the packaging container 3, thereby producing a patch containing package containing the patch 2. is obtained. Here, the softening composition 22 in the softening state having adhesiveness without fluidity, which protrudes and adheres to the end face side of the holding member, maintains the matured state.
In this way, a conventional patch containing package is manufactured.

Another example of the conventional manufacturing method of a patch containing package product is manufactured by the following steps.
The holding member/fluid efficacy composition raw material/peeling protective member laminate prepared by the steps (a) and (b-a) in FIG. seal the opening of the
Then, the holding member/fluid effect composition raw material/fluid effect composition raw material 22a of the peel protection member laminate housed in the packaging container is aged into the softening effect composition 22 having flexibility without fluidity. As a result, a patch 2 containing a patch having a holding member, a softening composition, and a peeling protective member is obtained.
Also in this conventional manufacturing method, as shown in FIG. decreases to a thickness H2, the flowable efficacy composition raw material 22a protrudes from the end surface of the holding member 21 with a length of L2, and while protruding, it flows and adheres to the end surface of the holding member. As shown in (c-a), the fluid benefit composition raw material 22a is aged from the fluid state to the flexible benefit composition 22 in a non-fluid and viscous soft state.

In the above-mentioned conventional patch containing package product containing a patch in a packaging container, a step of manufacturing a patch composed of a holding member, a softening composition, and a peel-protecting member, and attaching the patch. It is manufactured by two steps, one is the step of storing the agent in a packaging container and the other is sealing, and there is a demand for further efficiency improvement of the manufacturing process for manufacturing patch-containing packages.

In addition, if the patch is manufactured for a long period of time before it is placed in a packaging container, the ingredients contained in the softening effect composition may evaporate or evaporate during the manufacturing process, or may be contained due to chemical reactions with air. Content composition changes due to deterioration of components, etc., and this tends to destabilize the quality of the patch.

In addition, due to the inclusion of a manufacturing method in which the active composition raw material in a fluid state is laminated on the surface of the holding member in the conventional adhesive patch storage package, the thickness of the flexible efficacy composition that has matured into a flexible state, There is a tendency for the dimensional accuracy and positional accuracy of the planar shape and stacking position to vary, which is the cause of defective products.

In addition, in conventional patch containing packages, a patch is manufactured in which the flexible efficacy composition configured between the holding member and the peeling protective member protrudes from the edge between the holding member and the peeling protective member. defects tend to occur. When the adhesive patch that constitutes the protruding functional softening composition is placed in a packaging container, the protruding functional softening composition adheres to the inner surface of the packaging container, making it easy to remove the patch from the packaging container. There is a tendency for the inconvenience of not having one. Furthermore, when the patch is attached to the human skin, the protruding softening composition exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, and the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, there is a tendency that a portion of the back side of the holding member is sticky, giving an unpleasant feeling.

In addition, the holding member/fluid efficacy composition raw material/peeling protection member laminate composed of the holding member, the fluid efficacy composition raw material, and the peel protection member is housed in a packaging container and hermetically sealed. Even in the case of a patch storage package having a step of maturing a fluid efficacy composition raw material into a non-flowing flexible efficacy composition in the Defects tend to occur in which a patch is produced that protrudes from the edge between the member and the peel protection member. Since the patch that constitutes the protruding composition for softening is stored in the packaging container, the composition for softening that protrudes adheres to the inner surface of the packaging container, wrapping the patch. Inconvenience arises in that it cannot be easily removed from the container. Furthermore, when the patch is attached to the human skin, the protruding softening composition exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, and the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, there is a tendency that a portion of the back side of the holding member is sticky, giving an unpleasant feeling.

The present invention solves the above-mentioned problems, and provides a patch storage package that can be manufactured in a fewer number of steps than before, containing a patch in which a holding member, a flexible active substance, and a peeling protection member are laminated. A manufacturing method and a patch storage package are provided.
In addition, by solving the above-mentioned problems, a method for manufacturing and applying a patch storage package that can laminate a flexible efficacy composition on the surface of a holding member with high precision in terms of thickness, area, shape, lamination position, etc. To provide a drug storage package.
In addition, by solving the above problems, the present invention provides a method for manufacturing an adhesive patch storage package and an adhesive patch storage package capable of suppressing the phenomenon of the soft and effective composition being squeezed out between the holding member and the peeling protective member. .

The method for producing a patch containing package of the present invention comprises (a) a sheet-shaped holding member, a flexible composition adhered and bonded to the holding member and laminated, and the flexible composition. A patch having a sheet-like peeling protective member laminated on its surface so that it can be peeled off during use; The flexible efficacy composition has the property of being flexible, and at the time of use, the patch is taken out from the packaging container, the peel protection member is peeled off from the taken out patch, and the adhesive composition is laminated and bonded to the holding member. A method for manufacturing an adhesive patch containing package used by attaching an object to the skin of a human body, wherein the packaging container has flexibility to the extent that it can be deformed along the shape of the adhesive patch, and The softening benefit composition is prepared by adding at least water, a crosslinkable crosslinkable water-soluble polymer, and a cross-linking agent from a fluid benefit composition raw material to the crosslinkable water-soluble polymer over time. is chemically crosslinked into a three-dimensional structure to mature into a water-containing gel-like softening composition having adhesiveness and flexibility without fluidity; a step of preparing an effective composition raw material containing a polymer and a cross-linking agent; In this state, the effective composition raw material and the peeling protective member are laminated on a predetermined position region on the surface of the holding member with the peeling protective member positioned on the surface side, and the holding member, the effective composition raw material, and the peeling are carried out. Lamination member lamination step of preparing a protective member laminate; A laminate packaging step of sealing the opening of the packaging container in a reduced pressure state lower than atmospheric pressure to prepare a laminate containing package in which the inside of the packaging container is formed in a reduced pressure state lower than atmospheric pressure; As a result, the packaging container is brought into close contact along the shape of the holding member/effective composition raw material/peeling protective member laminate due to the pressure difference between the inside and outside of the packaging container, resulting in a deformed laminate. A storage package is obtained, and (D) the efficacy composition raw material constituting the laminate storage package is aged into a soft efficacy composition in a flexible state without fluidity, and the flexible efficacy composition is placed in the holding member. Adhering and bonding to prepare a holding member/softening composition/peeling protective member laminate in which the softening composition is adhered and bonded to the holding member Aging step, wherein the crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker, so that the active composition raw material becomes a water-containing gel-like soft gel having stickiness and flexibility without fluidity. A patch storage package is obtained in which a patch comprising a holding member, a flexible efficacy composition, and a peel-protecting member having a composition matured in an efficacy composition is formed, and the patch is stored in the packaging container. characterized by being

A patch containing package of the present invention comprises a patch and a packaging container containing the patch, wherein the patch adheres to a sheet-like holding member and a predetermined position area on the surface of the holding member. A softening composition that is bonded and laminated and has flexibility, and a sheet-like peeling protection member that is peelably laminated on the surface of the softening composition during use, wherein the softening composition is The softening effect having adhesiveness and having adhesiveness, wherein the adhesive patch is taken out from the packaging container at the time of use, the peel protection member is peeled off from the taken-out patch, and the adhesive is laminated and joined to the holding member. A patch storage package for use by applying the composition to the skin of a human body, wherein the packaging container has flexibility to the extent that it can be deformed along the shape of the patch, and the flexible efficacy composition The product is obtained from a fluid efficacy composition raw material containing at least a crosslinkable water-soluble polymer that can be crosslinked with water and a crosslinker, and the crosslinkable water-soluble polymer chemically changes with the passage of time. (i) the patch has the property of being crosslinked into a three-dimensional structure and matured into a water-containing gel-like softening composition having adhesiveness and flexibility without fluidity; The softening composition is laminated on the surface of the holding member so as to form a margin around the holding member positioned inside the periphery of the surface of the holding member, and the peeling protection member has the softening effect. (ii) the adhesive patch is formed in such a manner that it covers the composition and is in close contact with the peripheral margin of the holding member; The softening composition is layered on the surface of the holding member while being positioned on the surface region of the holding member, and the peeling protection member covers the surface of the softening composition and adheres to the edge of the holding member. The patch is formed in a form in close contact with the end portion of the softening effect composition, and the patch is placed in a packaging container and the pressure inside the packaging container is reduced below atmospheric pressure. has a form in which the agent is housed and sealed in the packaging container,
The crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker in a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch. The softening composition is characterized in that it has a matured form in which the softening composition is aged into a water-containing gel-like softening composition having stickiness and flexibility.

The present invention provides the following effects.
[Method Effect A: Adhesive storage of patches]:
According to the method for manufacturing a patch-containing package according to the present invention, a step of manufacturing a patch in which a holding member, a matured flexible active substance, and a peel-off protective member are laminated, and a step of storing the patch in a storage container. A patch that can form a patch having a softening composition that has been aged while being housed in a packaging container without going through both steps, and a patch containing the patch that has the aged composition having a softening effect As a result, it is possible to obtain the effect of being able to manufacture a package containing an adhesive patch that greatly simplifies the manufacturing process, improves mass productivity, and makes it possible to significantly reduce costs. be done.
In addition, since the softening effect composition is aged in the packaging container, the time from the production of the patch to the packaging container can be shortened.
In addition, changes in composition and chemical deterioration due to deterioration and deterioration of ingredients due to evaporation of ingredients contained in the softening composition during the manufacturing process or chemical reactions with air are suppressed, and stable quality is achieved. A patch having
Furthermore, in a state in which the packaging container is deformed along the shape of the holding member/effective composition raw material/releasing member laminate and closely attached, the flexible effective composition is matured and changed into a soft state, In addition, since the shape of the active composition raw material is maintained during aging, the active composition raw material sandwiched between the holding member and the peeling protective member is prevented from protruding from between the holding member and the peeling protective member. be. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated. Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use.

[Constructive effect A: patch storage package]:
In the patch containing package of the present invention, the patch is placed in a packaging container and the packaging container is in close contact along the shape of the patch. Due to the composition having a composition having a matured form that is aged in the form of the efficacy composition, the ingredients contained in the softening efficacy composition are altered or deteriorated due to evaporation or chemical reaction with the air. change in composition and chemical deterioration are suppressed, and an effect of obtaining a patch containing package having stable quality can be obtained.
Furthermore, since the shape of the active composition raw material is maintained during aging, the active composition raw material sandwiched between the holding member and the peeling protective member is prevented from separating from the holding member and the peeling protective member. Extrusion is prevented. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated.
Furthermore, when the patch is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side of the holding member is eliminated. , a patch storage package that can be used comfortably is obtained.

FIG. 2 is a process explanatory diagram and a schematic process diagram illustrating the manufacturing process of the manufacturing method of the adhesive patch containing package according to one embodiment of the present invention. FIG. 2 is a process explanatory diagram and a schematic process diagram illustrating the manufacturing process of the manufacturing method of the adhesive patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. FIG. 2 is a schematic plan view showing the shape of the softening composition contained in the patch contained in the patch containing package of one example of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic process diagram of a method for manufacturing a patch containing package according to one embodiment of the present invention. FIG. 2 is a schematic process diagram illustrating manufacturing steps of an example of a method for manufacturing a conventional patch containing package. FIG. 2 is a schematic process diagram illustrating manufacturing steps of an example of a method for manufacturing a conventional patch containing package.

Embodiments for carrying out the invention will be described below with respect to the method for manufacturing a patch containing packaged product and the patch containing packaged product of the present invention. In the drawings, the dimensions such as the shape, length, size, thickness, etc. of each component are not shown accurately, but are shown schematically.

FIG. 1 is a process explanatory drawing and a schematic process diagram for explaining the manufacturing process of the method for manufacturing a patch containing package according to one embodiment of the present invention.
In the schematic process diagrams illustrated in (A), (B), (C), and (D) of FIG. , a softening composition 22 adhered and laminated on the holding member 21 and having flexibility, and a sheet-like peeling protective member 23 laminated on the surface of the softening composition 22 so as to be peelable during use. and (b) a packaging container 3 containing the patch 2. The softening composition 22 has adhesive properties, and when used, the patch 2 is taken out from the packaging container 3, the peel protection member 23 is peeled off from the taken-out patch 2, and the softening composition 22 laminated and joined to the holding member 21 is applied to the human skin. A method for manufacturing a patch containing package 1 used as a patch, comprising the following configuration and steps.
The packaging container 3 has such flexibility that it can be deformed along the shape of the patch 2 . The softening effect composition is prepared from a flowable effect composition raw material containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent. The molecules are chemically cross-linked into a three-dimensional structure, and have the property of maturing into a water-containing gel-like softening composition with non-flowing adhesiveness and flexibility.
(A) A step of preparing an effective composition raw material containing at least water, a crosslinkable water-soluble polymer and a crosslinker.
(B) The beneficial composition is applied to a predetermined position area on the surface of the holding member in a state in which the ingredients of the beneficial composition are positioned inside the periphery of the surface of the holding member to form a peripheral blank portion of the holding member. Laminating member lamination step of laminating the raw material and the peeling protective member in a state that the peeling protective member is positioned on the surface side to prepare a holding member/effective composition raw material/peeling protective member laminate.
(C) The holding member/effective composition raw material/peeling protective member laminate is placed in the packaging container, and the pressure inside the packaging container is reduced below atmospheric pressure. a laminate packaging step of preparing a laminate containing package in which the opening is sealed to form a reduced pressure state lower than atmospheric pressure in the packaging container, whereby the packaging container is Due to the air pressure difference between the inside and the outside of the above, the holding member/effective composition raw material/peeling protective member laminate adheres along the shape of the laminate, resulting in a deformed laminate containing package.
as well as,
(D) Aging the active composition raw material constituting the laminate storage package into a softening effect composition in a non-fluid state and adhering and bonding the softening effect composition to the holding member to provide a softening effect. A maturing step of preparing a holding member-softening composition-release protection member laminate in which the composition is adhered and bonded to the holding member, wherein the cross-linkable water-soluble polymer is cross-linked by a chemical reaction with the cross-linking agent. Thus, the holding member, the softening composition, and the peeling protection member having a configuration in which the ingredients of the beneficial composition are matured into a water-containing gel-like softening composition having stickiness and flexibility without fluidity are provided. A patch storage package is obtained in which a patch is formed and the patch is housed in the packaging container.

This configuration provides the following effects.
The present invention provides the following effects.
[Method Effect A: Adhesive storage of patches]:
According to the method for manufacturing a patch-containing package according to the present invention, a step of manufacturing a patch in which a holding member, a matured flexible active substance, and a peel-off protective member are laminated, and a step of storing the patch in a storage container. A patch that can form a patch having a softening composition that has been aged while being housed in a packaging container without going through both steps, and a patch containing the patch that has the aged composition having a softening effect As a result, it is possible to obtain the effect of being able to manufacture a package containing an adhesive patch that greatly simplifies the manufacturing process, improves mass productivity, and makes it possible to significantly reduce costs. be done.
Furthermore, since the softening effect composition is aged in the packaging container, the time from the production of the patch to the packaging container can be shortened.
Furthermore, as a result, the content composition change and chemical deterioration due to the deterioration and deterioration of the ingredients due to the evaporation and emission of the ingredients contained in the softening composition during the manufacturing process or the chemical reaction with the air are suppressed, and the composition is stabilized. A plaster having a high quality is obtained.
Furthermore, in a state in which the packaging container is deformed along the shape of the holding member/effective composition raw material/releasing member laminate and closely attached, the flexible effective composition is matured and changed into a soft state, In addition, since the shape of the active composition raw material is maintained during aging, the active composition raw material sandwiched between the holding member and the peeling protective member is prevented from protruding from between the holding member and the peeling protective member. be. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated.
Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use.

<Containing fluid effective composition ingredients, vacuum packaging, manufacturing method>
In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method including the following steps can also be carried out.
The said benefit composition material is a fluid benefit composition material having a flowable fluid state, and has the following composition.
(A) A fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a flowable fluid state containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent.
(B) The fluidizing effect composition raw material is positioned in a region inside the periphery of the surface of the holding member to form a margin around the holding member, and the flowing effect is applied to a predetermined position region on the surface of the holding member. A laminating member lamination step of laminating the composition raw material and the peel protective member in a state in which the peel protective member is positioned on the surface side to prepare a holding member/effective composition raw material/peeling protective member laminate, wherein The fluid effective composition raw material has a predetermined shape and fluidity.
(C) The holding member/effective composition raw material/peeling protective member laminate is placed in the packaging container, and the pressure inside the packaging container is reduced below atmospheric pressure. A laminate packaging step of preparing a laminate-accommodating package in which the opening is sealed and the inside of the packaging container is formed in a reduced pressure state lower than the atmospheric pressure, wherein the fluid efficacy composition raw material has a predetermined shape. and maintain fluidity, and the packaging container is brought into close contact along the shape of the holding member/effective composition raw material/peeling protective member laminate due to the difference in air pressure between the inside and outside of the packaging container. As a result, a deformed laminate storage package is obtained.
as well as,
(D) aging the flowable composition raw material constituting the laminate housing package into a flexible composition in a non-fluid state, and adhering and bonding the flexible composition to the holding member to obtain a flexible composition; A maturing step of preparing a holding member/flexible benefit composition/release protective member laminate in which the benefit composition is adhered and bonded to the holding member, wherein the crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker. Thus, a holding member, a softening composition, and a peeling protection member having a structure in which the raw material of the fluid composition is matured into a water-containing gel-like softening composition having stickiness and flexibility without fluidity. A patch storage package is obtained in which the patch is formed and the patch is stored in the packaging container.

This configuration provides the following effects.
[Method Effect A: Fluid Effective Composition Raw Material]:
In addition to obtaining the aforementioned [Method Effect A: Adhesive storage of the adhesive patch], the packaging container is deformed along the shape of the holding member, the active composition raw material, and the peeling member laminate, and in a state of being in close contact, a flowable flow is obtained. In addition, the shape of the fluid performance composition raw material during aging is maintained because the fluid performance composition raw material having a state is aged and changed into a flexible performance composition having a non-flowable soft state having a retention shape. As a result, it is possible to prevent the flow benefit composition raw material sandwiched between the holding member and the peeling protective member from squeezing out from between the holding member and the peeling protective member. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated. Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use.

Although not shown, the holding member/effective composition raw material/peeling protective member laminate obtained in the step (B), or the laminate containing package obtained in the step (C) is placed at a predetermined interval. It is also possible to carry out a configuration comprising a step of passing between two rolls to further accurately adjust the thickness of the effective composition raw material and to further improve the adhesion between the holding member and the effective composition raw material.

The holding member 21 is not particularly limited, but for example, a material composed of a porous material having a fine uneven surface is desirably possible, and a part of the softening composition 22 is on the fine uneven surface of the holding member 21. The softening composition 22 adheres to the inside of the unevenness in a state of getting into the concave and convex portions, thereby obtaining a function and effect that the softening composition 22 in a soft state is joined to the holding member 21 without being peeled off.
Such a holding member 21 is not particularly limited, but it is desirable that the softening composition 22 permeates the holding member 21 and the softening composition 22 is sufficiently retained. Fiber aggregates such as non-woven fabrics or woven fabrics using fibers and natural fibers, and fiber aggregates such as paper can be used. In addition, as the holding member 21, a structure having stretchability is particularly desirable. The patch can be freely applied to the human body, and even after being applied, the patch expands and contracts freely in response to the movement of the human body, and the boundary between the holding member 21 and the softening composition 22 is not separated. 2 can be stably used without peeling off from the human body.

The peel protection member 23 is laminated on the surface of the softening composition 22 having stickiness to protect the surface of the softening composition, and is peeled off from the surface of the softening composition 22 when used.
The peel protection member 23 is not particularly limited, but it is suitable for protecting the surface of the softening composition 22 having stickiness during storage, such as polypropylene film, polyethylene film, polyester film, and other plastic films. , and can be easily peeled off from the surface of the softening composition 22 during use.

As the packaging container having flexibility to the extent that it can be deformed along the shape of the patch, a container having a configuration capable of suppressing or preventing intrusion of atmospheric air, a container having a desired function, and the like can be used. The material that can be used as the packaging container is not particularly limited, but for example, single-layer films such as plastic films and metal foils, or laminated laminate films can be used. Single-layer films include polyethylene terephthalate (PET) films, polyamide (nylon) films, polyvinyl alcohol films, polypropylene films, polyethylene films, ethylene-vinyl acetate copolymer films, polyacrylonitrile films, and others. A deformable plastic film or the like can be used. As the laminated laminate film, the deformable plastic film, metal foil sheet (e.g., aluminum foil sheet), paper sheet, kraft paper, woven fabric sheet, nonwoven fabric sheet, metal (e.g., aluminum) vapor-deposited plastic A laminate film obtained by laminating two or more kinds of sheet-like films such as a sheet made of a material can be used.
In addition, as a packaging container sheet having desired functions, a function of suppressing air permeation, a function of bending toughness, a function of preventing wrinkles, a function of being difficult to tear, a function of desired tearability, a function of printing characters, etc. Any sheet material having the desired functionality or other desired functionality can be used.
A configuration using a material that can significantly suppress the permeability of gas, air, humidity, etc. is also desirable and usable. For example, a laminate film composed of a metal foil such as aluminum foil or a plastic film having a metal vapor deposition film is particularly preferred. Desirably, this suppresses the transpiration of components such as water contained in the patch during storage of the patch storage package, and provides a flexible and effective composition due to the intrusion of air, putrefactive bacteria, etc. from the outside. The effect of suppressing deterioration and putrefaction of things can be obtained.
The thickness of the packaging container having flexibility to the extent that it can be deformed along the shape of the patch is not particularly limited, and varies depending on the material. Polyamide/high-density polyethylene multilayer laminate film, polyethylene terephthalate/aluminum foil/polyethylene terephthalate/polyethylene multilayer laminate film, kraft paper/aluminum foil/polyethylene multilayer laminate film, polyamide/aluminum-deposited polyethylene terephthalate/polyethylene multilayer laminate film Multi-layer laminated film, kraft paper/polyethylene terephthalate/aluminum foil/polypropylene multi-layer laminated film, aluminum-deposited polyethylene terephthalate/aluminum foil/polyethylene multi-layer laminated film to the extent that it can be deformed along the shape of the patch. The total thickness of the laminate film having flexibility of about 0.01 to about 0.3 mm is desirably practicable. The thickness of each plastic film sheet constituting the laminate film is preferably about 10 to about 100 μm, and the thickness of the aluminum foil is preferably about 5 to about 20 μm.
In addition, as a packaging container, it is possible to preferably implement a configuration in which the opening of a packaging container made of a laminate film having polyethylene or polypropylene as an inner layer is heated and pressed to seal the opening by heat sealing. The joint sealing of the opening is easily carried out.

<Raw materials for cooling non-deformable efficacy composition, reduced pressure packaging, and manufacturing method>
In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
FIG. 2 is a process explanatory diagram and a schematic process diagram illustrating another manufacturing process of the method for manufacturing a patch containing package according to one embodiment of the present invention. In FIG. 2, the manufacturing method of the patch containing package has the following configuration.
Said benefit composition ingredient is a cooled undeformed benefit composition ingredient having a cooled, undeformed state.
(A) a fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a flowable fluid state containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent;
as well as,
a cooling predetermined shape forming step of cooling the flowing benefit composition raw material to a temperature at which it becomes non-deformed to prepare a cooled non-deformed benefit composition raw material in a non-deformed state having a predetermined shape;
(B) in a state in which the cooling non-deformable effective composition raw material is positioned in a region inside the periphery of the surface of the holding member to form a holding member peripheral margin, the above-mentioned A laminating member lamination step of laminating the cooling non-deformable effective composition raw material and the peelable protective member with the peelable protective member positioned on the surface side to prepare a holding member/effective composition raw material/peeling protective member laminate; Here, the cooled non-deformed benefit composition material has a predetermined shape and maintains a non-deformed state.
(C) The holding member/effective composition raw material/peeling protective member laminate is placed in the packaging container, and the pressure inside the packaging container is reduced below atmospheric pressure. a laminate packaging step of preparing a laminate-accommodating package in which the opening is sealed and the inside of the packaging container is formed in a reduced pressure state lower than the atmospheric pressure, wherein the cooled non-deformed effective composition raw material is It has a predetermined shape and maintains a non-deformed state, and the packaging container adheres along the shape of the holding member/effective composition raw material/peeling protective member laminate due to the difference in air pressure between the inside and outside of the packaging container. A deformed laminate storage package is obtained.
as well as,
(D) Aging the active composition raw material constituting the laminate storage package into a softening effect composition in a non-fluid state and adhering and bonding the softening effect composition to the holding member to provide a softening effect. A maturing step of preparing a holding member-softening composition-release protection member laminate in which the composition is adhered and bonded to the holding member, wherein the cross-linkable water-soluble polymer is cross-linked by a chemical reaction with the cross-linking agent. Thus, the holding member, the softening composition, and the peeling protection member having a configuration in which the ingredients of the beneficial composition are matured into a water-containing gel-like softening composition having stickiness and flexibility without fluidity are provided. A patch-containing package is obtained in which a patch is formed and the patch is stored in the packaging container.
For example, as an example, in FIG. 2, the ingredient of the benefit composition is cooled to about -3° C. in step (A), maintained in the cooled state in steps (B) and (C), and (D) In the process, in a room temperature atmosphere of about 10° C. to about 30° C., or heated to about 30° C. to about 60° C., the ingredients of the efficacy composition turn into a hydrous gel during the heating process and/or at the elevated room temperature. It is possible to implement a method that results in a matured composition in the shape of a softening benefit composition.

This configuration provides the following effects.
[Method effect C: Cooling non-deforming effect composition raw material]:
The aforementioned [Method Effect A: Adhesive storage of the patch] is obtained, and the fluidity is improved in a state in which the packaging container is deformed and adheres to the shape of the holding member/effective composition raw material/peeling member laminate. In order to change the cooling non-deformed benefit composition raw material without flowability into a flexible benefit composition in a non-flowable state by aging, and to maintain the shape of the benefit composition raw material during aging, desired In addition, it is possible to prevent the raw material of the fluid benefit composition sandwiched between the holding member and the peeling protective member from squeezing out from between the holding member and the peeling protective member. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container is eliminated. Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use. In addition, it is possible to stably and accurately mass-produce patches with the desired performance without changing the ratio of the ingredients due to the evaporation of the ingredients during aging, and as a result, the yield of non-defective products can be significantly improved. Therefore, it is possible to stably mass-produce patches containing packages having desired quality, and to significantly reduce costs.

"Aging" means "aging from the ingredients of the efficacy composition into a softening efficacy composition", and the components such as the water-soluble polymer are chemically crosslinked from the one-dimensional chemical structure to form a mesh structure. Or, a phenomenon of changing to a three-dimensional chemical structure, or a phenomenon of changing from a fluid state to a non-fluid, flexible state without a fluid state, or a fluid state from a cooled solid state to a heated fluid state. It means the phenomenon of changing from a non-flowing state to a flexible state without
For example, "aging" means that the laminate containing package obtained in the (C) step is heated to a temperature of about 10 ° C. or higher in the (D) step, and crosslinked in the process of raising the temperature or in a room temperature atmosphere. It means a phenomenon that the soluble water-soluble polymer is cross-linked and the ingredient of the benefit composition is matured into a non-fluid, flexible state without a fluid state. For example, the effective composition raw material is heated from a cooled state to about room temperature of about 10° C. to 30° C., or to about 30° C. to 60° C., and in the process of heating or at the elevated temperature, the crosslinkable water-soluble highly It means a structure in which the molecules are cross-linked and the ingredient of the benefit composition is matured and changed into a non-fluid, flexible state without a fluid state.
The "flowable state" of the softening composition is obtained when the softening composition is placed in a polystyrene cup-shaped container of about 200 ml and the cup is tilted at an angle of about 45 degrees. , means a fluid state in which the softening benefit composition has properties such that it begins to flow and deform from the container within about 5 seconds.
The "non-deformed state" of the softening composition refers to a state in which the shape of the softening composition is not deformed in a stationary state without applying external pressure, and/or a tip edge angle of about 30 degrees, a high When the cooled non-deformable benefit composition is cut using a flat cutting device equipped with a double-edged push-cutting die with a width of about 5 mm, the cooled non-deformable benefit composition is cut into the desired shape without being deformed. means a non-deformed state that is cut and separated into the shape of
"Flexible state without fluidity" means that the surface of a holding member made of a non-woven fabric having flexibility, bending flexibility and air humidity permeability containing polyethylene terephthalate fibers of about 1 mm thickness and 300 mm square, has about When the softening composition was applied to a thickness of 3 mm and maintained at an angle of about 45 degrees for 60 seconds, the softening composition did not flow or deform, and returned to its original state. It means a state in which a shape is maintained and a non-deformed state is maintained.

<Raw materials for cut-cooled non-deformable composition, reduced-pressure packaging, and manufacturing method>
In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
FIG. 3 is a process explanatory diagram and a schematic process diagram illustrating another manufacturing process of the method for manufacturing a patch containing package according to an embodiment of the present invention. In FIG. 3, the manufacturing method of the patch containing package has the following configuration.
Said benefit composition material is a cut cooled non-deformed benefit composition material 22c having a predetermined shape that has been cooled and cut.
(A) a fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a flowable fluid state containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent, and the fluid efficacy composition raw material; is cooled to a temperature at which it becomes undeformed to form a cooled undeformed benefit composition material in an undeformed state, and then the cooled undeformed benefit composition material is cut into a predetermined shape to form a cut cooled undeformed benefit composition Predetermined shape forming process for preparing raw materials.
(B) in a predetermined position area on the surface of the holding member, in a state in which the cut cooling non-deforming effective composition raw material is positioned inside the periphery of the surface of the holding member to form a holding member peripheral margin, Lamination member lamination for preparing a holding member/beneficial composition raw material/peeling protective member laminate by laminating the cutting/cooling non-deformable effective composition raw material and the peelable protective member with the peelable protective member positioned on the surface side. step, wherein said cut cooled undeformed benefit composition stock has a predetermined shape and remains undeformed.
(C) The holding member/effective composition raw material/peeling protective member laminate is placed in the packaging container, and the pressure inside the packaging container is reduced to a level lower than the atmospheric pressure. a laminate packaging step of preparing a laminate-accommodating package in which the packaging container is formed in a reduced pressure state lower than the atmospheric pressure by sealing the opening, wherein the cut-cooled undeformed effective composition raw material; has a predetermined shape and maintains a non-deformed state, and the packaging container conforms to the shape of the holding member/effective composition raw material/peeling protective member laminate due to the difference in air pressure between the inside and outside of the packaging container. A deformed laminate storage package is obtained in a state of close contact.
as well as,
(D) Aging the active composition raw material constituting the laminate storage package into a softening effect composition in a non-fluid state and adhering and bonding the softening effect composition to the holding member to provide a softening effect. A maturing step of preparing a holding member-softening composition-release protection member laminate in which the composition is adhered and bonded to the holding member, wherein the cross-linkable water-soluble polymer is cross-linked by a chemical reaction with the cross-linking agent. Thus, the holding member, the softening composition, and the peeling protection member having a configuration in which the ingredients of the beneficial composition are matured into a water-containing gel-like softening composition having stickiness and flexibility without fluidity are provided. A patch storage package is obtained in which a patch is formed and the patch is housed in the packaging container.
For example, as an example, in FIG. 3, the ingredient of the benefit composition is cooled to about −3° C. and cut in step (A), and the cooled state is maintained in steps (B) and (C), In step (D), in a room temperature atmosphere of about 10° C. to about 30° C., or heated to about 30° C. to about 60° C., during the heating process and/or at the elevated temperature, the ingredients of the efficacy composition is matured into a water-containing gel-like softening composition.

This configuration provides the following effects.
[Method effect D: cutting cooling non-deforming effect composition raw material]:
The aforementioned [Method Effect A: Adhesive storage of the patch] and [Method Effect C: Cooling non-deforming effect composition raw material] are obtained, and the cooling non-deforming effect composition raw material is cut into a predetermined shape and cut and cooled non-deformable. It can be accurately cut into a desired planar shape and thickness shape in the predetermined shape forming process for preparing the active composition raw material, and since it is stored in a packaging container in close contact, the desired shape can be maintained during the aging process. Therefore, it is possible to easily manufacture a patch containing package having a desired shape without changing the shape. In addition, when cutting a softening composition having adhesiveness after aging, it is generally difficult to cut easily due to stickiness, and residue of the softening composition adheres to the cutting edge of the blade. On the other hand, the method of the present invention solves the above-mentioned problems, can be cut into a desired shape, and leaves residue of the softening composition. It is possible to cut easily without inconvenience such as reducing the amount of clothes, and as a result, the softening composition laminated on the holding member can be formed with high accuracy in the desired thickness, area, shape, weight, lamination position, etc. It becomes possible. In addition, since it is formed by transforming into a softening effect composition that has been aged in a packaging container, mass production of patch containing packages with stable quality without fluctuations in the ratio of the constituent components contained. Formable. The yield of non-defective products can be remarkably improved, patches containing packages having desired quality can be stably mass-produced, and costs can be reduced.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
FIG. 4 is a process explanatory drawing and a schematic process diagram explaining another manufacturing process of the manufacturing method of the adhesive patch containing package according to one embodiment of the present invention.
This configuration includes the following configuration in the step (B) provided with the cut-cooled non-deformed effective composition raw material.
(B) Each of the cut cooling non-deforming effective composition raw materials 22c is positioned in a position area forming a blank space at a predetermined interval on the surface of the holding member 21, and the peel protection member 23 is positioned on the surface side. Peel protection member 23 is laminated to cover each of the cut and cooled non-deformable effect composition raw materials 22c in the state of being positioned at the position of the blank portion, and then each of the cut and cooled non-deformable effect composition raw materials 22c is sandwiched between them at the position of the margin. A lamination member lamination step of cutting the peeling protective member 2 and the holding member 21 in the state of being cut to prepare a plurality of holding members/effective composition raw materials/peeling protective member laminates in this way, wherein the cutting The cooled undeformed benefit composition ingredient 22c remains undeformed.
Other steps are the same as those described with reference to FIG.
With this configuration, the same effect as the aforementioned [Method effect D: Raw material of cutting-cooling non-deformation effect composition] can be obtained.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
FIG. 5 is a process explanatory view and a schematic process diagram illustrating another manufacturing process of the method for manufacturing a patch containing package according to one embodiment of the present invention.
This configuration has the following configurations in the above-described steps (A) and (B).
(AB) a flow benefit composition raw material preparation step of preparing a flow benefit composition raw material having a flowable fluid state, and cooling the flow benefit composition raw material to a second cooling non-deformation temperature at which the flow benefit composition raw material is in a non-deformed state; forming a cooled non-deformed benefit composition raw material in a non-deformed state, and placing the cut cooled non-deformed benefit composition raw material and a peeling protective member in a predetermined position area on the surface of the holding member, the peeling protective member being positioned on the surface side; Laminating member lamination step of preparing a holding member/effective composition raw material/peeling protective member laminate by laminating in a state, after which the holding member/effective composition raw material/peeling protective member laminate is cut into a predetermined shape to form a plurality of pieces. A plurality of holding member/effective composition raw material/peeling protective member laminates are prepared in this manner. Here, the cut-cooled non-deformed benefit composition raw material remains in a non-deformed state.
Other steps are the same as those described with reference to FIG.
For example, as shown in FIG. 5, in the step (D), the temperature is raised to room temperature of about 10° C. or higher, or the temperature is raised to room temperature or higher, so that the ingredients of the efficacy composition have stickiness and flexibility without fluidity. A patch comprising a holding member, a softening composition, and a peel-protecting member having a composition matured into a water-containing gel-like softening composition is formed, and the patch is contained in the packaging container. A storage package is obtained.
With this configuration, the effect of [Method Effect D: Raw Material for Cutting, Cooling, and Non-Deformation Effective Composition] described above can be obtained.

The cutting method for cutting the cooling non-deformable benefit composition 22b into a predetermined shape is not particularly limited. For example, as shown in FIGS. A method of cutting the article 22b into a desired planar shape and/or a method of cutting the mass of cooled non-deforming benefit composition 22b into a desired thickness shape is feasible. Further, as a cutting device, a flat plate type pressure cutting device, a flat plate type pressure cutting device, a roll type pressure cutting device or a roll type pressure cutting device can be used to cut into a predetermined shape.
The cut shape is not particularly limited, but for example, the thin plate sheet-like cooled non-deformable benefit composition 22b is cut into any desired shape to obtain the aged softening benefit composition 22.
An embodiment of the softening benefit composition 22 formed by cutting the thin sheet of cooled non-deforming benefit composition into a desired shape and aging step is shown in FIG. FIG. 7 is a schematic plan view showing the shape of the softening composition 22 contained in the patch contained in the patch containing package of one embodiment of the present invention. In the plan view, (A) of FIG. 7 is substantially rectangular, (B) is substantially heart-shaped, and (C) and (D) have a partially removed shape with a predetermined area removed. .
In the cutting step, the bulk chilled undeformed benefit composition 22b may also be cut into a plurality of pieces to form a plurality of cut chilled undeformed benefit compositions 22c.

<Construction containing crosslinkable water-soluble polymer>
In the present invention, the softening effect composition is chemically structurally formed into a three-dimensional structure with the passage of time from a fluid benefit composition raw material containing at least water, a crosslinkable water-soluble polymer, and a crosslinker. It has the property of being crosslinked and matured into a water-containing gel-like softening composition having stickiness and flexibility without fluidity.
The crosslinkable water-soluble polymer is not particularly limited. At least one crosslinkable water-soluble polymer selected from the group consisting of cellulose, carboxyvinyl polymer, and salts thereof, and in the step (D), the crosslinkable water-soluble polymer reacts chemically with the crosslinker. A patch comprising a holding member and a softening composition, which is crosslinked by a reaction and thereby matured into a water-containing gel-like softening composition in which the ingredients of the composition are in a flexible state without fluidity. A patch-containing package is obtained in which the patch is stored in the packaging container while being formed.
These crosslinkable water-soluble polymers have crosslinkable functional groups in their chemical structural formulas and are chemically crosslinked into a three-dimensional structure in an aqueous solution.
As salts, metal salts such as sodium, potassium, or lithium are desirable, and metal salts such as calcium, zinc, or magnesium can also be used. A compound having a methyl group, an ethyl group, or a propyl group can be used as the alkyl group of the alkyl cellulose. A carboxyvinyl polymer having crosslinkability can be used as the carboxyvinyl polymer.

By mixing a cross-linking agent such as a divalent metal ion compound or a trivalent metal ion compound, these cross-linkable water-soluble polymers are cross-linked into a network structure and/or a three-dimensional structure in the chemical structural formula, and flow. It is in a flexible and soft state without elasticity, and it is matured and changed to a gel state with stickiness as well as shape retention and water retention.
Examples of cross-linking agents include, but are not limited to, aluminum chloride, calcium chloride, alum, potassium alum, iron alum, calcium hydroxide, magnesium chloride, ferric sulfate, ammonium alum, aluminum glycinate, aluminum glycinate, and sulfuric acid. Aluminum, aluminum potassium sulfate, aluminum ammonium sulfate, dihydroxy aluminum aminoacetate, aluminum hydroxide, aluminum silicate, aluminum phosphate, aluminum stearate, aluminum lactate, aluminum acetate, iron citrate, magnesium oxide, calcium oxide, aluminum hydroxide Magnesium, magnesium aluminometasilicate, and the like can be mentioned, and can be used alone or in combination of two or more.
A fluid softening composition containing water, a water-soluble polymer, and a cross-linking agent is such that the water-soluble polymer has a chemical structure of It is crosslinked into a mesh structure or a three-dimensional structure, and is matured and transformed into a flexible composition having shape retention properties without fluidity.
By selecting and including the type of cross-linking agent, it is possible to cross-link the water-soluble polymer at a desired temperature or speed. For example, in the step (D) in the method for producing a patch containing package, the ingredient composition containing the crosslinkable water-soluble polymer is heated at a temperature range of about 10°C to about 30°C around room temperature to obtain the water-soluble polymer. can be crosslinked into a network structure and/or three-dimensional structure in the chemical structural formula, and can be aged and changed to a gel state that has shape retention and water retention as well as stickiness in a flexible and soft state without fluidity. is. In addition, the cross-linking speed is remarkably slow at about 10° C. or less, and the cross-linking is accelerated in the temperature range of about 30° C. to 60° C., so that the manufacturing method can be carried out in a short time.

In the water-containing gel-like softening composition, the contents of water, the crosslinkable water-soluble polymer, and the cross-linking agent are not particularly limited. about 10% to about 98% by weight (preferably about 30% to about 95% by weight), and the content of the crosslinkable water-soluble polymer is about 0.5% to about 20% by weight (preferably about 1% to about 10% by weight), with a crosslinker content of about 0.001% to about 1% (desirably about 0.002% to about 0.5%). It is possible.
When the water content is less than about 10% by weight, or when the content of the crosslinkable water-soluble polymer exceeds about 20% by weight, the crosslinkable water-soluble polymer cannot be dissolved completely. There is a tendency not to obtain a softening benefit composition with the desired physical properties.
When the water content exceeds about 98% by weight, or when the content of the crosslinkable water-soluble polymer is less than about 0.5% by weight, the desired flexibility, shape retention, and tackiness can be achieved. There is a tendency not to obtain a gel-like softening benefit composition.
When the content of the cross-linking agent is about 0.001% by weight, the cross-linking reaction is insufficient, and there is a tendency that a water-containing gel-like softening composition exhibiting desired flexibility, shape retention, and adhesiveness cannot be obtained. There is If the content of the cross-linking agent exceeds about 1% by weight, a rapid cross-linking reaction will occur during mixing and preparation of the active composition raw materials in the preparation of the active composition raw materials, resulting in fluidity of the active composition raw materials. is not obtained, and there is a tendency that the desired composition ingredients cannot be laminated on the holding member.

In addition to one or more of the crosslinkable water-soluble polymers described above, it is also possible to use a non-crosslinkable, non-crosslinkable water-soluble polymer in combination as ingredients for the effective composition.
Examples of non-crosslinkable, non-crosslinkable water-soluble polymers include polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide, starch acrylic acid copolymer, alkyl cellulose, graft starch, alginic acid, gelatin, carrageenan, agar, gelatin, pectin, and locust bean. Contains one or more synthetic and/or natural water-soluble polymers such as gum, xanthan gum, gum arabic, tragacanth gum, gellan gum, Ernest gum, agarose, dextrin, glucomannan, polyglutamic acid, and salts thereof It is also possible to implement a configuration that
By appropriately selecting the types of cross-linkable water-soluble polymer, cross-linking agent, non-cross-linkable water-soluble polymer, other additives, etc., and the molecular weight, degree of polymerization, etc. of these water-soluble polymers, the desired adhesion can be obtained. A emollient composition can be prepared by designing it as desired to have flexibility, pliability, and retention.

The structure containing the above-described crosslinkable water-soluble polymer has the aforementioned [Method Effect A] and also provides the following [Method Effect C-a] and [Method Effect C-b] effects.
[Method Effect Sa-a: Crosslinkable water-soluble polymer, water-containing gel-like softening composition, room temperature aging]
In this configuration, by designing and including both types of the crosslinkable water-soluble polymer and the crosslinker, it is possible to obtain a water-containing gel-like softening composition that is crosslinked and aged at a desired temperature. It is possible. For example, it is possible to obtain a crosslinked water-containing gel-like softening composition at a temperature of about 30°C or less without having to raise the temperature to a temperature above about 30°C. That is, in step (A), there is a "fluid efficacy composition raw material preparation step of preparing a fluid efficacy composition raw material having a flowable state in an atmosphere of room temperature of about 10°C to about 30°C", and (D ) in the step “Aging and changing the efficacy composition raw material constituting the laminate storage package into a flexible efficacy composition in a flexible state without fluidity in an atmosphere of about 10° C. to about 30° C. of room temperature. and a maturing step of adhering and bonding the softening composition to the holding member to prepare a holding member/softening composition/peeling protective member laminate in which the softening composition is adhered and joined to the holding member, whereby the efficacy A patch comprising a holding member, a softening composition, and a peeling protection member having a configuration changed by aging a composition raw material into a softening composition having a flexible state without fluidity is formed, and the patch is formed. A patch-containing package stored in the packaging container is obtained." can be implemented. In other words, in both the (A) process and the (D) process, it is possible to carry out the manufacturing in an atmosphere of about 10° C. to about 30° C. of room temperature.
In addition, with this configuration, it is possible to obtain the effect of suppressing evaporation of water due to temperature rise, preventing fluctuations in the contained composition, and suppressing thermal deterioration of the contained components due to temperature rise.
Furthermore, the gel component and medicinal components of the hydrous gel composition can be freely designed, and when the patch is applied to the human body, the patch exhibits a moderate cooling sensation due to the hydrous component and a medicinal effect due to the medicinal component. In addition, a patch which can minimize skin irritation and which is gentle on the skin is obtained.
Further, in the state of being housed in the packaging container, the ingredients of the efficacy composition are crosslinked to form a three-dimensional network chemical structure, and the matured water-containing gel-like softening efficacy composition having a gel-like soft state without fluidity. Therefore, it is possible to remarkably suppress changes in the content composition of the efficacy composition due to evaporation of moisture, etc. during aging, and to stably produce a patch having desired adhesiveness and flexibility. Become.
Furthermore, by selecting the type of cross-linking agent, it becomes possible to cross-link at around room temperature, so that the softness effect composition is cross-linked by cross-linking the effect composition raw materials in the state of being housed in the packaging container. can be produced, and the production time can be significantly reduced compared to the case where the crosslinked patch is stored in a packaging container.
Furthermore, the cost of electric power required for heating and raising the temperature is also reduced, so that an effect of inexpensive manufacturing can be obtained.
In addition, by selecting and containing the desired type of cross-linking agent, the cross-linking rate is remarkably slow at about 10 ° C. or less, and the cross-linking is promoted in the temperature range of about 30 ° C. to 60 ° C., making it possible to manufacture in a short time. A method is also operable. By this method, the fluidity of the fluid efficacy composition raw material is maintained for a long time, so the time from the preparation of the fluid efficacy composition raw material in step (A) to the laminate packaging step in step (C) can be adjusted as desired. A designable manufacturing method is obtained.

[Method Effect Sa-b: Crosslinkable water-soluble polymer, water-containing gel-like softening composition, protrusion suppression]:
A water-containing gel-like softening composition that is further formed between the holding member 21 and the peeling protection member 23 by the manufacturing method for forming the water-containing gel-like softening composition containing the crosslinkable water-soluble polymer. The phenomenon that the substance 22 protrudes from the edge between the holding member 21 and the peeling protective member 23 is remarkably suppressed, and a patch can be obtained. The inconvenience that the adhesive patch 2 cannot be easily removed from the packaging container 3 due to stickiness is also eliminated, and furthermore, when the adhesive patch 2 is applied to the human skin, the protruding water-containing gel-like softening composition 22 is eliminated. The user's discomfort caused by the stickiness of the surface of the patch 2 that is not supported by the holding member 21 is remarkably suppressed, and the patch storage package 1 can be manufactured.

<Regarding the configuration provided with the cooled non-deformable cooling effective composition raw material>
In particular, in a configuration containing a water-containing gel-like softening composition containing water, a crosslinkable water-soluble polymer, and a cross-linking agent, the water-containing gel composition raw material 22a having fluidity is cooled to a non-fluidity It is possible to implement a configuration including a lamination member lamination step of laminating the cooled non-deformed benefit composition raw material 22b in a fluid form or non-deformed state on the holding member, and this configuration provides the following effects.
[Method effect: crosslinkable water-soluble polymer, water-containing gel-like softening composition, cooling]:
[Method Effect A], [Method Effect C-a], and [Method Effect C-b] are obtained, and in particular, [Method Effect C: Cooling non-deformation effect composition raw material] is remarkably exhibited. .

<Regarding the configuration provided with the cut cooled non-deformable effective composition raw material that has been cooled and cut>
In particular, in a configuration containing a water-containing gel softening composition containing water and a crosslinkable water-soluble polymer, the water-containing gel composition raw material 22a having fluidity is cooled to obtain a non-fluid form or It is possible to implement a configuration including a predetermined shape forming step of cutting the prepared cooled non-deformed benefit composition raw material 22b in the non-deformed state to prepare the cut cooled non-deformed benefit composition raw material 22c. The following effects are obtained.
[Method effect: water-soluble polymer, water-containing gel-like softening composition, cooling, cutting]:
The water-containing gel composition raw material 22a having fluidity is cooled to prepare a cooled non-deformable effect composition material 22b in a non-fluid or non-deformed state, which is cut and cooled. (Method effect S: water-soluble polymer/water-containing gel-like softening effect composition) is obtained by a configuration including a predetermined shape forming step for preparing the composition raw material 22c, and cutting and cooling into a predetermined shape by cutting with high accuracy. A non-deforming benefit composition ingredient can be obtained.
Furthermore, the aforementioned [Method effect A: Adhesive storage of the patch] and [Method effect C: Cooling non-deforming effect composition material] are obtained, and the cooling non-deformation effect composition material 22b is cut into a predetermined shape. In the case of providing a predetermined shape forming step for preparing the cooled non-deformable effective composition raw material 22c, it can be accurately cut into a desired planar shape and thickness shape, and is stored in close contact with the packaging container. Therefore, the desired shape does not change during the aging process, and a patch having a desired shape can be easily produced.
In addition, when cutting the water-containing gel-like softening composition 22 having adhesiveness after aging, it is generally difficult to cut easily due to the adhesiveness, and the water-containing gel-like softening composition is generally difficult to cut due to the adhesiveness. There is a problem that it is difficult to cut repeatedly due to the adhesion of the residue of the composition 22, but by the method of the present invention, the above problem can be solved, and the water-containing material can be cut into a desired shape. The gel softening composition 22 can be easily cut without any inconvenience such as suppressing the amount of deposits such as residues of the gel softening composition 22. As a result, the hydrogel softening composition 22 laminated on the holding member can be cut to a desired thickness. The thickness, area, shape, weight, lamination position, etc. can be formed with high accuracy. In addition, since the water-containing gel-like softening composition 22 that has been aged in a sealed packaging container is obtained, the ratio of the components contained does not change, and the ratio of the components contained does not fluctuate. Thus, it is possible to obtain an adhesive patch storage package having a high quality, remarkably improve the yield of non-defective products, stably mass-produce an adhesive patch having a desired quality, and significantly reduce costs.
Furthermore, the drawback that the hydrous gel composition adheres to the blade used for cutting is suppressed, and the occurrence of defects during mass production is suppressed, resulting in a marked improvement in productivity.

As the softening composition 22, a softening composition containing a medicinal ingredient having percutaneous absorbability and exhibiting a medicinal effect that the medicinal ingredient exerts when applied to the skin of the human body can be used.
Examples of active ingredients include, but are not limited to, indomethacin, loxoprofen, loxoprofen sodium, ketoprofen, diclofenac, diclofenac sodium, piroxicam, suprofen, ibuprofen, ketorolac, lidocaine, flurbiprofen, terbinafine, capsaicin, psyllium bacillus extract, mefenamic acid, Dipotassium glycyrrhizinate, menthol, camphor, hyaluronic acids, salicylates, arbutin, tocopherol acetate, allantoin, vitamins, azulenes, acrinol, psyllium extract, other plant extracts, arbutin, tocopherol acetate, vitamin Cs, water-soluble azulene, Pain relievers such as polyphenols, ecozymes, placenta extracts, anti-inflammatory agents, nutritional supplements, tranquilizers, warming agents, cooling agents, moisturizing agents, whitening agents, agents for eliminating skin stains and freckles, and other percutaneously absorbable agents, etc. can be used.

The following effects are obtained by the composition containing the above medicinal ingredients.
[Method effect set: active ingredient-containing softening effect composition]:
As the emollient composition 22, a patch storage package that exhibits a medicinal effect corresponding to the contained medicinal ingredient can be obtained by further containing a percutaneously absorbable medicinal ingredient.
In addition to these medicinal ingredients, preservatives, bactericides, pH adjusters, aroma oils, fragrances, fragrances, coloring agents, antioxidants, Antioxidants, skin absorption accelerators, ultraviolet absorbers, inorganic fillers, polyhydric alcohols, silicone oils, surfactants, viscosity modifiers, fine powders, and other desired additives may also be added.
These ingredients in the water-containing gel-like softening composition gradually permeate the surface or inside of the skin at the application site of the body, and the effect resulting from these ingredients can be obtained along with the cooling and moisturizing effects. .

The above-mentioned aroma oils and fragrances are not particularly limited, but for example, essential oil components (essential oils) generally used in aromatherapy can be used as they are. Essential oil components include, for example, those described in Wonder Cellar, "84 Essential Oil Components for Aromatherapy", Fragrance Journal. Anise, chamomile, carrot seed, grapefruit, sage, geranium, celery, thyme, tarragon, turpentine, frankincense, violet, pine, parsley, lemon, lemongrass, rosemary, laurel, cornflowers, almonds, camphor, Examples include, but are not limited to, extracts from plum, dandelion, chimo, black rose, mint, peach, eucalyptus, coix seed, lavender, forsythia, and the like.

Furthermore, in the water-containing gel-like softening composition, a composition that additionally contains a lower alcohol that enhances the cooling and cold insulation effect by generating heat due to volatilization, a cooling agent such as menthol and peppermint oil, and a warming agent such as capsaicin and hot pepper extract. is also feasible. In addition, in the water-containing gel-like softening effect composition, a pH adjusting agent such as citric acid, tartaric acid, lactic acid, salts thereof, and/or sodium hydroxide is added to adjust the pH to a range of 4 to 10. , more preferably, it is desirable to adjust the pH in the range of 6-8.

In order to obtain the desired adhesiveness and flexibility of the water-containing gel-like softening composition, a constitution containing a tackifier, a softening agent, a plasticizer, etc. can also be carried out. Examples of tackifiers include, but are not limited to, rosin, hydrogenated rosin, rosin ester, hydrogenated rosin ester, polyterpene, phenol resin, xylene resin, other aliphatic resins, petroleum resins, and alicyclic hydrocarbons. Resin or the like can be used.
Softeners and plasticizers include polybutene, polyisobutylene, silicone, vaseline, solid paraffin, liquid paraffin, limonene, pinene, almond oil, olive oil, camellia oil, persic oil, peppermint oil, sesame oil, soybean oil, cottonseed oil, and corn oil. , egg yolk oil, safflower oil, etc. can be used.

Skin absorption enhancers include lanolin, liquid paraffin, beeswax, menthol, limonene, pinene, piperitone, terpinol, carveol, jojoba oil, almond oil, olive oil, camellia oil, persic oil, peppermint oil, sesame oil, soybean oil, and mink oil. , cottonseed oil, corn oil, etc. can be used.
Glycerin, propylene glycol, butylene glycol, dipropylene glycol, octanediol, polyethylene glycol, sorbitol, and the like can be used as polyhydric alcohols.
As the silicone oil, methylsiloxane, methylphenylpolysiloxane, dodecamethylpolysiloxane and the like can be used.

<Manufacturing patch storage packages by vacuum sealing>
In the method of manufacturing a patch-containing package of the present invention, in step (C), "the holding member, the raw material for the efficacy composition, and the release member laminate are placed in a packaging container, and the packaging container is Lamination for preparing a laminate containing package by sealing the opening of the packaging container so that the holding member/effective composition raw material/peeling member laminate is deformed along the shape and brought into close contact. FIG. 6 shows a schematic diagram of an embodiment of the "product packaging process".
As shown in FIG. 6(A), in the step (C), the holding member/effective composition raw material/peeling member laminate is placed in the packaging container 3 while being placed in the packaging container 3. The opening of the packaging container 3 is sealed while the inside is in a state of reduced pressure lower than the atmospheric pressure to prepare a laminate housing package in which the inside of the packaging container is formed in a reduced pressure state lower than the atmospheric pressure. A laminate packaging step is provided, whereby the packaging container 3 is brought into close contact along the shape of the laminate of the holding member/effective composition raw material/peeling protective member due to the pressure difference between the inside and outside of the packaging container. A laminate containing package deformed into a state is obtained.
In FIG. 6, a configuration is illustrated in which the benefit composition raw material is the cooled undeformed benefit composition raw material 22b. A configuration is also possible.

This configuration provides the following effects.
[Method effect: decompression adhesion]:
The opening of the packaging container 3 is sealed while the holding member/effective composition raw material/releasing member laminate is positioned in the packaging container and the interior of the packaging container is reduced to a pressure lower than the atmospheric pressure. and a laminate packaging process for preparing a laminate containing package in which the inside of the packaging container is in a reduced pressure state lower than the atmospheric pressure, so that the packaging container 3 is separated from the inside and outside of the packaging container. To easily obtain a laminate containing package product in which the packaging container 3 is easily brought into close contact along the shape of the holding member/effective composition raw material/peeling protective member laminate due to the pressure difference between the As a result, it is possible to stably mass-produce the adhesive patch containing package 1 in which the packaging container 3 is closely attached along the shape of the adhesive patch 2 .
In particular, in a patch comprising a holding member made of a porous material having a finely uneven surface as the holding member 21, due to the pressure difference between the inside and outside of the packaging container, the non-woven fabric having a finely uneven surface becomes unusable. The effective composition raw material 22a adhering to the surface of the holding member 21 is a film-like film positioned on the front side and the back side of the holding member/effective composition raw material/peeling protective member laminate with the peeling protective member 23 interposed therebetween. While sandwiched between the packaging containers, the holding member 21 and the effective composition raw material 22a are pressurized against each other, whereby a part of the effective composition raw material 22a enters the inside of the fine irregularities on the surface of the holding member 21. In this state, the effect composition raw material 22a is crosslinked and aged to be changed into the softening effect composition 22 in a soft state without fluidity, and in this way, the softening effect composition 22 in a soft state is obtained. It is possible to obtain the effect of forming a patch configured by bonding without peeling from the holding member 21 .
The holding member, the raw material for the efficacy composition, and the peeling member laminate are subjected to pressure difference between the inside and outside of the packaging container without passing through pressure means such as pressure with two rolls or pressure with a flat pressurizing press. As a result, part of the beneficial composition raw material 22a adheres to the holding member 21 in a state of entering into the unevenness of the finely uneven surface, and the flexible beneficial composition 22 in a soft state without fluidity is formed on the retaining member 21. It is possible to manufacture a patch that is bonded without peeling off from the adhesive.

The reduced pressure state lower than the atmospheric pressure is not particularly limited, but a reduced pressure state in which the packaging container can be deformed by the pressure due to the difference between the inside of the packaging container and the atmospheric pressure is desirable, for example, about 5 mmHg to about 700 mmHg. is desirable. Particularly preferably, the reduced pressure state is in the range of about 20 mmHg to about 500 mmHg. Incidentally, the atmospheric pressure is approximately 760 mmHg.
In the case of a vacuum higher than about 5 mmHg, a long vacuum suction operation is required to create a reduced pressure state, which tends to lower productivity and vaporizes and evaporates the components contained in the softening composition. There is a concern that the contained components may deteriorate due to evaporation or the like. In the case of about 700 mmHg to about 760 mmHg, since the difference from the atmospheric pressure is small, the state in which the packaging container closely contacts and deforms along the shape of the holding member/effective composition raw material/peeling protective member laminate is reduced. , there is a tendency that it becomes impossible to obtain a patch storage package that is in a deformed state in close contact with the shape of the patch.

The holding member/effective composition raw material/releasing member laminate is placed in a packaging container, and the opening of the packaging container is sealed while the inside of the packaging container is in a reduced pressure state lower than the atmospheric pressure. The laminate packaging process for preparing the laminate containing package in which the inside of the packaging container is formed in a reduced pressure state lower than the atmospheric pressure is not particularly limited, but for example, the following method can be implemented.
・Reduced-pressure sealing method a: As shown in FIG. 6(A), a packaging container serving as a packaging container is placed at both the upper and lower positions of the holding member/effective composition raw material/releasing member laminate. In a state where the sheet for packaging is positioned, the laminate is positioned between the sheets for packaging containers and in a reduced pressure atmosphere, and the opening of the sheet for packaging containers is sealed to seal the packaging container sealing part A method of forming 3a and then returning the sealed bag-like packaging container to the atmosphere. As a result, it is possible to easily manufacture a laminated product containing package in which the packaging container is easily deformed into a state in which it is brought into close contact along the shape of the holding member/effective composition raw material/peeling protective member laminate.
・Reduced-pressure sealing method b: As shown in FIG. The opening of the bag-shaped packaging container is sealed to form a packaging container sealing portion 3a with only the inside of the bag-shaped packaging container being decompressed, and then the sealed bag-shaped packaging container is closed. How to return to atmosphere. As a result, it is possible to easily manufacture a laminated product containing package in which the packaging container is easily deformed into a state in which it is brought into close contact along the shape of the holding member/effective composition raw material/peeling protective member laminate.
・Reduced pressure sealing method c: As shown in FIG. While the bag-like packaging container containing the laminate is placed in a reduced pressure atmosphere, the opening of the bag-like packaging container is sealed to form the packaging container sealing portion 3a, and then the sealed bag-like shape is formed. A method of returning a packaging container to atmospheric conditions. As a result, it is possible to easily manufacture a laminated product containing package in which the packaging container is easily deformed into a state in which it is brought into close contact along the shape of the holding member/effective composition raw material/peeling protective member laminate.

In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method having the following configuration can also be carried out.
The packaging container is made of a material that melts and fuses when heated, and in the step (C), by heating the opening of the packaging container 3, the opening of the packaging container 3 melts and fuses. It is characterized by being joined and hermetically sealed.
This configuration provides the following effects.
[Method effect: thermal fusion bonding of opening]:
The packaging container is made of a material that melts and fuses when heated, and by heating the opening of the packaging container, the opening of the packaging container melts and fuses and joins and seals. With this configuration, it is possible to easily obtain a laminate-containing package product in which the packaging container is easily deformed into a state of closely contacting along the shape of the holding member/effective composition raw material/peeling protective member laminate. As a result, it is possible to stably mass-produce patch-accommodating packages in which the packaging container adheres along the shape of the patch.

In packaging containers to be sealed under reduced pressure, materials used for heat-sealable packaging containers are not particularly limited, but for example, at least a heat-sealable plastic film and a sheet having a desired function. Laminated films with similar materials can be used. A polyethylene film, a polypropylene film, or the like is used as the heat-sealable plastic film. Examples of sheet materials having desired functions include polyethylene terephthalate (polyester) films, polyamide (nylon) films, paper, woven fabrics, non-woven fabrics, metal foils (e.g. aluminum foil), and metal vapor-deposited films (e.g. aluminum vapor-deposited polyester films). , and other general-purpose plastic films can be used. Sheets with desired functions include the ability to suppress air permeation, the ability to have bending toughness, the ability to prevent wrinkles, the ability to resist tearing, the desired tearability, the ability to print characters, and other functions. Any sheet material having the desired functionality can be used.
In addition, in this configuration, it is also possible to apply a configuration in which the opening of the packaging container is heated and pressed, thereby facilitating the bonding of the opening.

<Method for Forming Peripheral Margin of Holding Member>
In the manufacturing method of the adhesive patch containing package of the present invention, a manufacturing method including the following steps can also be carried out.
In the step (B), the peel protection member is placed in a state in which the effective composition raw material is positioned inside the periphery of the surface of the holding member to form the holding member peripheral blank portion 21a. The effective composition raw material and the peel protective member are laminated in a state of being located on the surface side of the holding member peripheral blank portion.
In the step (C), the holding member/beneficial composition raw material/peeling protective member laminate is placed in a packaging container, and the peeling protective member covers the flexible benefit composition and the holding member. The opening of the packaging container is sealed so that the packaging container deforms along the shape of the laminate and comes into close contact with the peripheral margin of the holding member.
For example, in the (B) process of FIG. 1, the (B) process of FIG. 2, and the (B) process of FIG. It is laminated on the surface of the holding member 21 while forming the peripheral blank portion 21a.

This configuration provides the following effects.
[Method effect co-a: Margin around holding member]:
In the method of manufacturing the patch containing package of the present invention, particularly in the "(B) step, the active composition raw material is positioned inside the periphery of the surface of the holding member to form a margin around the holding member. In the state where the peel protection member is located on the surface side of the effective composition raw material and the margin around the holding member, the effective composition raw material and the peel protection member are laminated to form the holding member, the effective composition raw material, and the peel protection. In a state in which the member laminate is positioned in the packaging container, the peel protective member covers the softening composition and is in close contact with the holding member peripheral margin of the holding member, and the packaging container takes the shape of the laminate. The opening of the packaging container is sealed so that it is deformed along and comes into close contact". The phenomenon that the softening composition 22 formed between 21 and the peeling protective member 23 protrudes from the edge between the holding member 21 and the peeling protective member 23 is remarkably suppressed, and a patch can be obtained. As a result, the sticking-out softening composition 22 adheres to the inner surface of the packaging container 3, and the inconvenience that the patch 2 cannot be easily removed from the packaging container 3 is also eliminated, and the patch 2 can be applied to the human skin. In such a case, the user's discomfort caused by the stickiness of the softening composition protruding from the surface or side of the holding member 21 is eliminated, and the patch storage package can be used comfortably. product is obtained.
Furthermore, when the patch 2 is applied to the skin of the human body, the user feels discomfort due to stickiness on the surface of the patch 2 caused by the protruding softening composition 22 not being supported by the holding member 21. It is also possible to obtain the effect of being able to manufacture the adhesive patch containing package 1 in which the amount of the patch is remarkably suppressed.

In the holding member peripheral blank portion 21a located inside the periphery of the surface of the holding member 21, the distance from the periphery of the holding member surface to the softening composition 22, that is, the width dimension of the holding member peripheral blank portion 21a is It is desirable that the distance and length dimensions are at least equal to or greater than the thickness dimension of the effective composition raw material 22 . For example, when the effective composition material 22 laminated on the holding member 21 has a thickness of 2 mm, the width of the holding member margin 21a is preferably about 2 mm or more. This suppresses the protrusion of the softening composition 22 . If the width dimension of the holding member peripheral blank portion 21a is smaller than the thickness dimension of the beneficial composition raw material 22, the effect of suppressing the protrusion of the softening beneficial composition 22 tends to decrease.

In the manufacturing method of the adhesive patch containing package of the present invention, a configuration including the following steps can also be implemented.
In the step (B), the effective composition raw material is positioned on the surface of the holding member without protruding from the surface of the holding member, and the end surface of the effective composition raw material is positioned between the holding member and the peeling member. The effective composition raw material is laminated on the surface of the holding member so as to be exposed, and the release member is laminated on the surface of the effective composition raw material.
In the step (C), the holding member/effective composition raw material/peeling protection member laminate is positioned in a packaging container, and the packaging container is placed in the holding member/effective composition raw material/peeling protective member laminate. The opening of the packaging container is sealed so that it deforms along the shape of the member stack and comes into close contact.

For example, it has steps as shown in FIG.
(A) A step of preparing a fluid benefit composition material 22a having a flowable fluid state, and cooling the fluid benefit composition material 22a to a temperature at which it is in a non-deformed state to form a predetermined shape. a cooling predetermined shape forming step for preparing the cooled non-deformed effective composition raw material 22b in the non-deformed state.
(B) The cooling non-deforming effect composition raw material 22b and the peeling protection member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peeling protection member 23 positioned on the surface side. A lamination member lamination step for preparing a benefit composition raw material/peel protective member laminate, wherein the cooled non-deformed beneficial composition raw material 22b is maintained in a non-deformed state, and the beneficial composition raw material is released from the surface of the holding member. The effective composition raw material is placed on the surface of the holding member so that it is positioned on the surface of the holding member without protruding and the end surface of the effective composition raw material is exposed from between the holding member and the peeling member. The cooled non-deformed benefit composition material 22b, which is laminated and laminates the release member to the surface of the benefit composition material, remains in an undeformed state.
(C) The holding member/effective composition raw material/peeling protective member laminate is placed in the packaging container, and the pressure inside the packaging container is reduced to a level lower than the atmospheric pressure. a laminate packaging step of preparing a laminate-accommodating package in which the opening is sealed and the inside of the packaging container is formed in a reduced pressure state lower than the atmospheric pressure, wherein the cooled non-deformed effective composition raw material is It has a predetermined shape and maintains a non-deformed state, and the packaging container adheres along the shape of the holding member/effective composition raw material/peeling protective member laminate due to the difference in air pressure between the inside and outside of the packaging container. A deformed laminate storage package is obtained.
(D) Aging the active composition raw material constituting the laminate storage package into a softening effect composition in a non-fluid state and adhering and bonding the softening effect composition to the holding member to provide a softening effect. A maturing step of preparing a holding member-softening composition-release protection member laminate in which the composition is adhered and bonded to the holding member, wherein the cross-linkable water-soluble polymer is cross-linked by a chemical reaction with the cross-linking agent. Thus, the holding member, the softening composition, and the peeling protection member having a configuration in which the ingredients of the beneficial composition are matured into a water-containing gel-like softening composition having stickiness and flexibility without fluidity are provided. A patch-containing package is obtained in which a patch is formed and the patch is stored in the packaging container.
For example, as an example, in FIG. 8, the ingredient of the benefit composition is cooled to about −3° C. in step (A), maintained in the cooled state in steps (B) and (C), and (D ) step, the temperature is raised to a room temperature of about 10° C. to about 30° C. or to about 30° C. to about 60° C., and in the process of raising the temperature and/or at the raised temperature, the ingredients of the efficacy composition contain water. It is possible to implement a process that results in a gel-like softening benefit composition that is a matured composition.

This configuration provides the following effects.
[Method Effect C-b: End face close contact packaging of softening composition]:
With this configuration, the aforementioned [Constructive Effect A: Adhesive storage of patch] can be obtained, and the flexible composition 22 formed between the holding member 21 and the peeling protective member 23 is formed between the holding member and the peeling protective member. It is possible to obtain a patch 2 in which the phenomenon of protruding from the edge of the gap is remarkably suppressed. Furthermore, when the adhesive patch 2 is applied to the human skin, the softening composition protruding from the surface or side of the holding member 21 is sticky. In addition, it is possible to obtain an adhesive patch storage package that can be used comfortably without the user's discomfort in the attached state.

In the above configuration, the fluid efficacy composition raw material 22a and the peeling member 23 are laminated on the surface of the holding member 21, and then the laminate of the holding member 21, the fluid efficacy composition raw material 22a, and the peeling member 23 is packaged. The packaging container is sealed along the shape of the laminate, and in the sealed state, the fluid efficacy composition raw material 22a is stored in a non-fluid flexible efficacy composition. Configurations having a step of aging and changing the morphology are also possible. With this configuration, the same effect as the aforementioned [Method Effect Co-b: Close contact packaging of softening composition] can be obtained.

<Regarding patch storage packages>
A patch containing package 1 of the present invention includes a patch 2 and a packaging container 3 containing the patch 2. The patch 2 is a sheet-like holding member 21 and a surface of the holding member 21. a flexible softening composition 22 which is adhered and bonded to and laminated in a predetermined position area of , and a sheet-like peeling protection member which is peelably laminated on the surface of the softening composition 22 during use. 23, the softening effect composition 22 has adhesiveness, and at the time of use, the patch 2 is taken out from the packaging container 3, and the peel protection member 23 is peeled off from the taken out patch 2. The patch storage package 1 is used by applying the softening composition 22 laminated and bonded to the holding member 21 to the skin of a human body, wherein the packaging container 3 contains the patch 2 and the softening composition 22 has fluidity containing at least water, a crosslinkable crosslinkable water-soluble polymer, and a crosslinker. From the effective composition raw material 22a, the crosslinkable water-soluble polymer is chemically crosslinked into a three-dimensional structure with the passage of time, resulting in a water-containing gel-like flexible effective composition having stickiness and flexibility without fluidity. (i) In the patch 2, the softening composition 22 is positioned inside the periphery of the surface of the holding member 21 to form a holding member peripheral margin 21a. The softening composition 22 is laminated on the surface of the holding member 21 in such a state that the peeling protection member 23 covers the softening composition 22 and the margin 21a around the holding member 21. or (ii) the adhesive patch 2 is formed in a state in which the softening composition 22 is positioned on the surface region of the holding member 21 without protruding from the surface of the holding member 21 . The softening composition is laminated on the surface of the holding member 21, and the peeling protection member 23 covers the surface of the softening composition 22, and the edge of the holding member 21 and the softening composition 22 are separated. formed in close contact with the end of the
The patch 2 is placed in the packaging container 3 and the pressure inside the packaging container 3 is reduced below atmospheric pressure, and the patch 2 is housed and sealed in the packaging container 3. The crosslinkable water-soluble polymer is cross-linked by chemical reaction with the cross-linking agent, and the softening composition 22 has an aged form in which the softening composition 22 is aged into a water-containing gel-like softening composition having stickiness and a soft state. It is characterized by

This configuration provides the following effects.
[Constructive effect A: patch storage package]:
In the patch containing package of the present invention, the softening efficacy composition has a softened state in a state in which the patch is positioned in the packaging container and the packaging container adheres along the shape of the patch. Due to the composition having a composition having a matured form, the content of the ingredients contained in the softening composition is reduced due to the deterioration or deterioration of the ingredients due to evaporation or chemical reaction with the air. It is possible to obtain an effect of obtaining an adhesive patch storage package having stable quality by suppressing changes in composition and chemical deterioration.
Furthermore, in order to provide a configuration in which the shape of the flowing efficacy composition raw material is maintained during aging, the separation between the holding member and the peeling protective member for the beneficial composition raw material sandwiched between the holding member and the peeling protective member is prevented from sticking out. As a result, the inconvenience of not being able to easily remove the adhesive patch from the packaging container caused by the protruded softening composition adhering to the inner surface of the packaging container can be eliminated. Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.

In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker in a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch. In the aged form obtained by aging the softening composition in the form of a softening composition having a softening state, the patch is positioned in the packaging container and the packaging container has the shape of the patch. The crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker in a state of being in close contact along the line, and the softening effect composition is changed from a flowable effect composition raw material having a fluid state to a fluid It is characterized by comprising a composition that is a matured form obtained by aging in the form of a softening effect composition having a softening state that does not have a softening state.

This configuration provides the following effects.
[Structural effect B: patch storage packaging product/raw material for fluid efficacy composition]:
The above-described (structural effect a) can be obtained, and the flexible composition 22 laminated on the holding member 21 can be formed with high accuracy in desired thickness, area, shape, weight, lamination position, etc., and Thus, a patch containing package 1 having a desired quality can be obtained stably without fluctuations in the composition component ratios contained during aging or the like.
Furthermore, the flow benefit composition raw material 21a sandwiched between the holding member 21 and the peeling protective member 23 is prevented from protruding from between the holding member 21 and the peeling protective member 23. FIG. As a result, the inconvenience of not being able to easily remove the adhesive patch 2 from the packaging container 3 due to the protruded softening composition 22 adhering to the inner surface of the packaging container 3 is eliminated.
Furthermore, when the patch 2 is applied to the skin of the human body, the softening composition 22 protruding out is not supported by the holding member 21 and the surface of the patch 2 is tacky. It is possible to obtain an adhesive patch storage package that eliminates the pleasant feeling and can be used comfortably.
Furthermore, the gel component of the water-containing gel-like softening composition 22 can be freely designed. The emollient composition 22 is harmless to human skin, and a skin-friendly patch can be obtained.
Furthermore, the adhesive patch 2 having the desired performance can be stably mass-produced with high precision without fluctuations in the ratio of the contained component caused by the evaporation of water, which is the contained component, during aging. can be remarkably improved, patches of desired quality can be stably mass-produced, and a patch containing package 1 can be obtained that makes it possible to significantly reduce costs.

The patch of the present invention is placed in the packaging container and the packaging container is in close contact along the shape of the patch, and the crosslinkable water-soluble polymer chemically reacts with the crosslinking agent. The aged form in which the softening composition is crosslinked by the softening composition and aged into a softening composition having a softening state, wherein the patch is positioned in the packaging container and the packaging container is the The non-deformable cooling effect of the softening composition having a non-deformed state after being cooled by cross-linking the cross-linkable water-soluble polymer through a chemical reaction with the cross-linking agent in a state of adhering to the shape of the patch. The agent storage is characterized in that it is a matured form that is matured in the form of a softening effect composition having a flexible state in which the form of the composition raw material is changed to a non-fluid form without fluidity. Packaged goods WHEREIN: The following structure is also implementable.

This configuration provides the following effects.
[Structural effect C: patch storage packaging product/cooling non-deformation effective composition raw material]:
The aforementioned [Constructive effect A: Adhesive storage of the patch] is obtained, and the beneficial composition 22 sandwiched between the holding member 21 and the peeling protective member 23 does not protrude from between the holding member 21 and the peeling protective member 23. is prevented. As a result, the inconvenience of not being able to easily take out the patch 2 from the packaging container due to the protruded softening composition 22 adhering to the inner surface of the packaging container 3 is eliminated, and the patch storage package 1 is obtained. . Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the protruding softening composition not being supported by the holding member 21. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably. In addition, it is possible to stably and accurately mass-produce patches with the desired performance without changing the ratio of the ingredients due to the evaporation of the ingredients during aging, and as a result, the yield of non-defective products can be significantly improved. Thus, it is possible to stably mass-produce patch containing packages 1 having desired quality, and to obtain the patch containing packages 1 that enable significant cost reduction.

In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker in a state in which the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch. The aged form obtained by aging the softening composition in the form of a softening composition having a softening state is such that the patch is positioned in the packaging container and the packaging container has the shape of the patch. The crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker, and the softening composition is cooled and cut in a non-deformed state. It is characterized by having a composition having a matured form aged in the form of a softening effect composition having a flexible state in which the form of the composition raw material is changed to a non-fluid form without fluidity. do.

This configuration provides the following effects.
[Structural effect D: patch storage packaging product/cutting cooling non-deforming effective composition raw material]:
In addition to obtaining the aforementioned [Constructive Effect A: Adhesive storage of the patch] and [Constructive Effect C], the cut cooling non-deformable efficacy composition raw material 22c cut into a predetermined shape has an accurate desired plane shape and thickness shape. and is stored in close contact with the packaging container 3, a patch containing package having a desired shape can be obtained.
In addition, since the softening composition is cut into a desired shape and maintains its shape, the softening composition laminated on the holding member has a desired thickness, area, shape, weight, lamination position, etc. can be formed with high accuracy.
In addition, since the softening effect composition 22 aged in the packaging container 3 is composed, the composition component ratio of the aged softening effect composition 22 does not fluctuate and the composition component ratio of the softening agent is stabilized. A patch-containing package 1 containing the efficacy composition 22 is obtained.
Furthermore, the gel component of the water-containing gel-like softening composition 22 can be freely designed. The emollient composition 22 is harmless to human skin, and a skin-friendly patch can be obtained.
Furthermore, the phenomenon that the water-containing gel-like softening composition 22 formed between the holding member 21 and the peeling protective member 23 protrudes from the end portion between the holding member 21 and the peeling protective member 23 is remarkably suppressed, and the adhesive patch is removed. As a result, the inconvenience of not being able to easily remove the patch from the packaging container caused by the protruding water-containing gel-like softening composition sticking to the inner surface of the packaging container is also eliminated. Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.
Furthermore, the patch 2 having desired performance can be mass-produced stably and with high accuracy without changing the ratio of the ingredients caused by the evaporation of water, which is the ingredient, during aging.
In addition, the water-containing gel-like softening effect composition material 22a is cooled and cut into the cooled non-deformed effect composition material 22b to form the cut and cooled non-deformed effect composition material 22c in a predetermined shape. In , the disadvantage that the water-containing gel-like beneficial composition raw material adheres to the blade used for cutting is suppressed, and the occurrence of defects during mass production is also suppressed, thereby significantly improving productivity.
In this way, the yield of non-defective products is remarkably improved, patches of desired quality can be stably mass-produced, and patch-containing products at reduced costs can be obtained.

In the patch containing package of the present invention, "the patch is positioned in a packaging container and the inside of the packaging container is in a reduced pressure state lower than the atmospheric pressure, and the patch is placed in the packaging container. The crosslinkable water-soluble The macromolecule is crosslinked by a chemical reaction with the crosslinking agent, and the softening composition is aged into a water-containing gel-like softening composition having adhesiveness and flexibility. effect is obtained.

[Construction effect: decompression adhesion]:
The patch 2 is placed in the packaging container 3 and the pressure inside the packaging container 3 is reduced below atmospheric pressure, and the patch 2 is stored and sealed in the packaging container 3. and the packaging container 3 is in close contact with the shape of the patch 2, thereby obtaining the aforementioned [Constructive Effect A: Adhesive storage of the patch], and at the same time, It is possible to obtain a product in which the patch storage package 1 in which the container 3 is in close contact with the shape of the patch 2 is stably mass-produced. In addition, the softening composition 22 sandwiched between the holding member 21 and the peeling protective member 23 is prevented from squeezing out from between the holding member 21 and the peeling protective member 23 . As a result, the inconvenience of not being able to easily remove the patch 2 from the packaging container 3 due to the protruded softening composition sticking to the inner surface of the packaging container 2 is eliminated, and the patch storage package 1 is completed. can get. Furthermore, when the patch 2 is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side surface of the holding member 21 is eliminated. It is possible to obtain an adhesive patch storage package that eliminates the problem and can be used comfortably.
In particular, in a patch composed of a porous material having a finely uneven surface as the holding member 21, due to the pressure difference between the inside and outside of the packaging container, the adhesive sticks to the surface of the holding member 21. The effective composition raw material 22 is sandwiched between the film-like packaging containers located on the front side and the back side of the holding member/effective composition raw material/peeling protective member laminate via the peeling protective member 23. , the holding member 21 and the benefit composition raw material 22 are pressed against each other, whereby a part of the softening benefit composition 22 adheres to the inside of the unevenness of the finely uneven surface of the holding member 21 and is aged. Therefore, it is possible to obtain an effect that a patch is obtained in which the softening composition 22 in a soft state without fluidity is adhered to the holding member 21 without being peeled off.

In the patch containing package of the present invention, "the patch is placed in a packaging container and the inside of the packaging container is in a reduced pressure state lower than the atmospheric pressure, and the patch is placed in the packaging container. In the configuration of "having a form of being housed and sealed", a configuration in which the opening of the packaging container is welded and sealed is desirably practicable.
This configuration provides the following effects.
[Structural effect: heat fusion bonding of the opening]: A laminate that is easily adhered along the shape of the patch due to the structure in which the opening of the packaging container is fusion-bonded and sealed. A patch that makes it possible to easily obtain a packaged product, suppresses the intrusion of air into the packaged product, and maintains a state in which the packaging container adheres to the shape of the patch for a long period of time. A drug containing package is obtained.

In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The crosslinkable water-soluble polymer is at least polyacrylic acid, neutralized polyacrylic acid, partially neutralized polyacrylic acid, acrylic acid-methacrylic acid copolymer, carboxyalkyl cellulose, hydroxyalkyl cellulose, carboxyvinyl polymer. and at least one crosslinkable water-soluble polymer selected from the group consisting of salts thereof, wherein the crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker, thereby forming an effective composition raw material. is matured into a water-containing gel-like softening composition having a soft state without fluidity.
As salts, metal salts such as sodium, potassium, or lithium are desirable, and metal salts such as calcium, zinc, or magnesium can also be used. A compound having a methyl group, an ethyl group, or a propyl group can be used as the alkyl group of the alkyl cellulose. A carboxyvinyl polymer having crosslinkability can be used as the carboxyvinyl polymer.
With this configuration, [structural effect A: crosslinkable water-soluble polymer, water-containing gel-like softening effect composition, and room temperature aging]: the aforementioned [structural effect A: adhesive patch storage package] can be obtained with a particularly remarkable effect.
In addition, in the patch storage package obtained by maturing the fluid efficacy composition raw material to the flexible efficacy composition, [Constructive effect C]: the above-mentioned [Constructive effect C: Patch storage package/cooling effect composition raw material] , is obtained with a particularly remarkable effect.
In addition, in the patch storage package obtained by aging the cooling effect composition raw material to the softening effect composition, [Constructive effect C]: [Constructive effect C: Patch storage package/cooling effect composition raw material] , is obtained with a particularly remarkable effect.
In addition, in the patch storage package obtained by aging the cutting and cooling effect composition raw material to the softening effect composition, [Constructive effect]: The above-mentioned [Constructive effect D: Patch containing package product/cutting and cooling non-deformation effect composition raw material] can be obtained with particularly remarkable effects.

"(i) In the patch, the softening composition is positioned inside the periphery of the surface of the holding member so as to form a margin around the holding member. The softening composition is laminated on the surface of the holding member, and the peel protection member covers the softening composition and is formed in close contact with the holding member peripheral margin of the holding member. The following [construction effect co-a: holding member peripheral margin] is obtained.

[Structural effect co-a: Margin around holding member]:
In the patch 2, the softening composition 22 is laminated on the surface of the holding member 21 in such a state that the softening composition 22 is positioned inside the periphery of the surface of the holding member 21 to form a holding member peripheral blank portion 21a. At the same time, the peel protection member 23 covers the softening composition 22 and is formed in close contact with the holding member peripheral margin 21 a of the holding member 21 , so that the packaging container 3 conforms to the shape of the patch 2 . The above-mentioned [Construction Effect A] is obtained, and the softening composition 22 formed between the holding member 21 and the peeling protection member 23 is separated from the holding member 21 The phenomenon of protruding from the edge between the adhesive layer and the peeling protective member 23 is remarkably suppressed, and the adhesive patch 2 can be obtained. Inconvenience that the agent cannot be easily removed from the packaging container is also eliminated, and furthermore, when the patch 2 is applied to the human skin, the softening composition protruding from the surface or side of the holding member 21 has stickiness. The user's discomfort in the applied state caused by this problem can be eliminated, and a patch containing package product that can be used comfortably can be obtained.

In the holding member peripheral margin 21a located inside the periphery of the surface of the holding member 21, the distance from the periphery of the holding member to the periphery of the softening composition 22, that is, the width dimension of the holding member peripheral margin 21a is preferably at least equal to or greater than the thickness dimension of the softening composition 22. For example, when the thickness of the softening composition laminated on the holding member 21 is 2 mm, the width dimension of the holding member peripheral margin 21a is preferably about 2 mm or more. As a result, a patch in which the softening composition 22 is suppressed from being pushed out is obtained. If the width dimension of the holding member peripheral blank portion 21a is smaller than the thickness dimension of the softening composition 22, the effect of suppressing the softening composition from sticking out tends to decrease.
This configuration is illustrated, for example, in FIG. 1D, FIG. 2D, and FIG. 3D.

In the adhesive patch storage package of the present invention, "(ii) the adhesive patch is configured such that the adhesive composition is positioned on the surface region of the holding member without protruding from the surface of the holding member. The benefit composition was laminated on the surface of the holding member, and the peel protection member covered the surface of the softening composition and adhered to the end of the holding member and the end of the softening composition. The following [structural effect code: a margin around the holding member] is obtained by the structure of "formed in the shape".
[Structural Effect Co-b: End face close contact packaging of softening composition]:
"The patch is formed by laminating the softening composition on the surface of the holding member in such a manner that the softening composition is positioned on the surface region of the holding member without protruding from the surface of the holding member, and The peeling protective member covers the surface of the softening composition and is formed in close contact with the end of the holding member and the end of the softening composition. It is possible to obtain a patch 2 in which the phenomenon that the softening composition 22 formed between the protective member 23 and the protective member 23 protrudes from the edge between the holding member and the peeling protective member is remarkably suppressed, and as a result, When a patch constituting the protruding composition for softening is stored in a packaging container, the patch caused by sticking of the composition for softening that protrudes to the inner surface of the packaging container can be easily removed from the packaging container. The inconvenience of not being able to remove the adhesive patch 2 is also eliminated, and when the adhesive patch 2 is attached to the human skin, the softening composition protruding from the surface or side surface of the holding member 21 is sticky, which is caused by stickiness. It is possible to obtain an adhesive patch storage package that eliminates the user's discomfort in such a situation and allows comfortable use.

In the adhesive patch storage package of the present invention, the following configuration can also be implemented.
The emollient composition 22 contains water and/or a medicinal ingredient, and the peel protection member 23 of the patch 2 taken out from the packaging container 3 is peeled off from the emollient composition 22 to remove the holding member. When the softening composition 22 laminated and bonded to 21 is applied to the human skin and used, the cooling effect is caused by the water and/or the medicinal ingredients contained in the softening composition 22. and/or have a medicinal effect.
This configuration provides the following effects.
[Constructive effect: cooling effect/medicine effect]
It is also possible to implement a configuration in which the softening composition 22 contains a component that has a cooling effect or a cooling effect and/or a medicinal component that has a medicinal effect, and such a component that has a cooling effect or a cooling effect and/or an excellent cooling sensation or cooling sensation and/or a medicinal effect can be obtained when a patch containing a medicinal ingredient that exerts medicinal effects is applied to the skin of the human body.
The component that exhibits a cooling effect or a cooling sensation effect is not particularly limited, but water, menthol, etc. can be used, for example.
The medicinal ingredient that exerts a medicinal effect is not particularly limited. Medicinal ingredients that exhibit analgesic and anti-inflammatory effects, such as biprofen and terbinafine, can be implemented.

Typical examples of the method for producing a patch and the patch of the present invention are described below.

(Exemplary Example 1: Preparation of raw materials for various fluid efficacy compositions)
(Typical Example 1-1)
Fluid efficacy composition raw material preparation step for preparing A1 fluid efficacy composition raw material 22a having a flowable fluid state:
A first melt is obtained by mixing polyacrylic acid, sodium polyacrylate, sodium carboxymethylcellulose and water in an atmosphere of room temperature of about 25°C. Separately, polyvinyl alcohol is added to water and dissolved to obtain a second dissolved product. These first melt, second melt, glycerin, paraben, menthol, tartaric acid, a cross-linking agent, and the remaining water are added and well stirred and mixed. A cross-linking agent aqueous solution prepared separately is added to this and mixed.
Thus, 2 g of polyacrylic acid, 4 g of sodium polyacrylate, 3 g of polyvinyl alcohol, 18 g of glycerin, 1 g of sodium carboxymethylcellulose, about 0.1 g of menthol, about 0.1 g of parabens, a trace of tartaric acid, a trace of a cross-linking agent (sulfuric acid Aluminum, aluminum hydroxide) and water (the balance) totaling 100 g of A1 fluid efficacy composition raw material 22a is prepared.
The A1 fluid efficacy composition raw material 22a thus prepared has a fluid state in which it can flow in a temperature range of about 10° C. or higher, and can be cut into a semi-solid state by being cooled in a temperature range of about 3° C. or lower. In a temperature range of about 7° C. to about 30° C. when the temperature is raised from the cooled state, the composition is crosslinked to form a non-fluid, water-containing gel-like softening composition. In addition, in the temperature range of about 7° C. to about 30° C., the water-soluble polymer contained in the A1 fluid efficacy composition raw material 22a is crosslinked to form a network structure with a three-dimensional structure in the chemical structural formula, resulting in fluidity. It has a property of being aged and changed into a water-containing gel-like softening composition having non-sticky and shape-retaining properties. In addition, the water-containing gel-like softening composition in a non-fluid state has the property of maintaining the non-fluid state even when the temperature is raised to about 40°C.
A patch comprising this water-containing gel-like softening composition has an effect of exhibiting a cooling effect or a cooling sensation effect when used by being attached to the human body.
In addition, the A1 flow benefit composition raw material 22a undergoes a cross-linking reaction immediately after mixing with the cross-linking agent in an atmosphere of room temperature of about 25° C., and gradually changes from a gel-like flow state to flexibility without fluidity. It has the property of aging and changing into a softening effect composition. Usually, the fluidity gradually decreases immediately after mixing the cross-linking agent, and after about 60 minutes, it becomes a non-fluid state with no fluidity. It has the property of being aged and changed into a softening effect composition having flexibility.

(Typical Example 1-2)
Fluid efficacy composition raw material preparation step for preparing A2 dynamic efficacy composition raw material 22a having a flowable fluid state:
Example 1-1 described above further includes a step of adding about 0.1 g of indomethacin as a medicinal ingredient having an analgesic and anti-inflammatory effect and mixing and dissolving. In this way, the A2 fluid efficacy composition raw material 22a in which each component is uniformly mixed is prepared.
The A2 fluid efficacy composition raw material 13a thus prepared has a fluid state in which it can flow in a temperature range of about 10°C or higher, and a non-deformable state in which it can be cut in a temperature range of about 3°C or lower. In the temperature range of about 7°C to about 30°C, it becomes a non-fluid, water-containing gel-like softening composition.
In addition, in the temperature range of about 7° C. to about 30° C., the water-soluble polymer contained in the A2 fluid efficacy composition raw material 22a is crosslinked to form a network structure with a three-dimensional structure in the chemical structural formula, resulting in fluidity. It has a property of being aged and changed into a water-containing gel-like softening composition having non-sticky and shape-retaining properties. In addition, the water-containing gel-like softening composition in a non-fluid state has the property of maintaining the non-fluid state even when the temperature is raised to about 40°C.
A patch comprising this water-containing gel-like softening composition has a cooling effect or a cooling sensation effect as well as an analgesic and anti-inflammatory effect when applied to the human body.
In addition, the A1 flow benefit composition raw material 22a undergoes a cross-linking reaction immediately after mixing with the cross-linking agent in an atmosphere of room temperature of about 25° C., and gradually changes from a gel-like flow state to flexibility without fluidity. It has the property of aging and changing into a softening effect composition. Usually, the fluidity gradually decreases immediately after mixing the cross-linking agent, and after about 60 minutes, it becomes a non-fluid state with no fluidity. It has the property of being aged and changed into a softening effect composition having flexibility.

(Typical Example 2-1)
With regard to a typical example of a method for manufacturing a patch containing package containing a patch containing a water-containing gel-like softening composition exhibiting a cooling effect or a cooling sensation effect, the patch containing package shown in Fig. 1 will be described. A manufacturing method will be described.

・[Step A: Fluid efficacy composition raw material preparation step]:
A water-containing gel-like A1 flow benefit composition raw material 22a having crosslinkability prepared in (Typical Example 1-1) is prepared.

[Step B: Lamination member lamination step: Holding member/raw material for fluid composition/peel protection member lamination step]:
As shown in FIG. 1(B), a sample containing polyethylene terephthalate fibers, other fibers, a binder, etc., having a thickness of about 1 mm, a vertical width of about 50 mm, and a horizontal width of about 120 mm, has bending flexibility, stretchability, and air humidity. A holding member 21 made of a permeable needle-punched nonwoven fabric is prepared. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Separately, a peel protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 50 mm, and a width of about 120 mm is prepared.
In a room temperature atmosphere of about 25° C., the A1 fluid efficacy composition raw material 22a prepared in the above step A is added to the A1 fluid efficacy composition raw material 22a in a state where a holding member peripheral margin 21a of about 5 mm is formed on the surface of the holding member 21. Within about 20 minutes after the composition raw material is prepared, it is adhered and laminated in a shape of about 2 mm in thickness, about 40 mm in length, and about 110 mm in width. A peeling protective member 23 is laminated in such a manner as to cover the above, and thus a holding member/effective composition raw material/peeling protective member laminate is prepared.
In this step, a plastic frame having a vertical width of about 40 mm and a horizontal width of about 110 mm is placed inside the holding member peripheral margin 21a on the surface of the holding member 21, and a fluid gel is placed inside the frame. A1 fluid efficacy composition material 22a having a thickness of about 2 mm, a vertical width of about 40 mm, and a horizontal width of about 110 mm so as to form a holding member peripheral blank portion 21a by charging the A1 fluid efficacy composition material 22a. are laminated on the surface of the holding member 21 .

・ [C: Laminate packaging step] step:
As shown in FIG. 1(C), it consists of three layers of a polyethylene film (about 40 μm thick), an aluminum foil (about 9 μm thick), and a polyethylene terephthalate film (about 12 μm thick). A film-like packaging container 3 having a thickness of about 0.07 mm (about 70 μm) is prepared, which is bonded with a thick adhesive. Here, the film-like packaging container 3 has a state in which its periphery is opened, and at least the size of the holding member/effective composition raw material/peeling protective member laminate (vertical width of about 50 mm, horizontal width of about 120 mm) also has a shape larger than about 5 mm. Separately, prepare a vacuum packaging device (not shown) that is equipped with a vacuum pump and a heat sealing device inside the chamber and that can reduce the pressure inside the chamber.
In an atmosphere of room temperature of about 25° C., within about 30 minutes after the preparation of the raw material for the A1 flowing benefit composition, the above-mentioned laminate of the holding member, the raw material for the benefit composition, and the peelable protective member is placed between the polyethylene layers of the packaging container. Positioned between two upper and lower film-like packaging containers 3 facing each other, in that state, the inside of the vacuum packaging device is decompressed to a reduced pressure state of about 100 mmHg or less, and the holding member and effect are reduced in the reduced pressure state. The opening in the area spaced apart by about 5 mm or more from the periphery of the composition raw material/peeling protective member laminate is pressed and heated by a heat sealer, and the opening of the packaging container 3 is melt-fused and joined. sealed.
After that, the inside of the chamber is returned to atmospheric pressure (approximately 760 mmHg, normal pressure). As a result, the periphery of the packaging container 3 is heat-sealed, and the interior of the packaging container 3 is decompressed, and the holding member, the ingredient of the efficacy composition, and the peeling of the ingredients contained in the packaging container 3 are peeled off. In a state where the protective member laminate is positioned in the packaging container 3, the packaging container 3 is deformed along the shape of the holding member, the active composition raw material, and the peeling protective member laminate and is in a state of close contact. A product storage package is prepared. That is, due to the pressure difference between the inside and the outside of the packaging container, the packaging container 3 is deformed along the shape of the holding member/effective composition raw material/peeling protective member laminate and adheres to the laminate. product is obtained.
Here, the peel protection member 23 covers the surface and edges of the active composition raw material 22a and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in contact with the holding member and the active composition. It is possible to obtain a laminated product storage package that is deformed along the shape of the raw material/peeling protective member laminated product and is in close contact with the product.

・[D: Effective composition raw material maturing step] step:
As shown in (D) of FIG. 1, the laminate housing package prepared in the step (C) is placed in an atmosphere of room temperature of about 25° C. for about 60 minutes or more.
In a state of being placed in an atmosphere of about 25° C., the fluid efficacy composition raw material 22a constituting the laminate containing package is crosslinked to the flexible efficacy composition 22 in a flexible state without fluidity to age and change. The softening composition 22 is adhered to the holding member 21 to form a holding member/softening composition/peeling protective member laminate in which the softening composition 22 is adhered/bonded to the holding member 21 . As a result, the fluidizing composition raw material 22a is matured into the flexible composition 22 having stickiness and lacking fluidity, and thus the adhesive patch 2 is equipped with a holding member, a flexible composition, and a peeling protective member. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.

Here, the packaging container 3 is kept in close contact with the surface and edges of the fluid efficacy composition material 22a and the peripheral blank portion 21a of the holding member 21 via the peel protection member 23. 22a is crosslinked with a softening composition 22 to be aged, and the patch 2 comprising a holding member, a softening composition and a peel protection member laminate is stored in a packaging container 3. is obtained. That is, the peel protection member 23 covers the surface and edges of the flexible composition 22 and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in a state where the holding member and the flexible composition are in close contact. It is possible to obtain an adhesive patch storage package that is deformed along the shape of the object/peeling protective member laminate and adheres to the laminate. In particular, the softening composition 22 is adhered to the surface of the holding member 21 while forming the peripheral margin 21a of the holding member 21 without protruding from the surface of the holding member 21, thereby obtaining a patch containing package.

In addition, due to the pressure difference between the inside and outside of the packaging container, the effective composition raw material 22a adhering to the surface of the nonwoven fabric holding member 21 having a fine uneven surface is held through the peeling protection member 23. The holding member 21 and the efficacy composition raw material 22a are pressed against each other while being sandwiched between the film-like packaging containers positioned on the front side and the back side of the laminate of the member/effective composition raw material/peeling protective member. As a result, a state is formed in which part of the effective composition raw material 22a enters into the unevenness of the fine uneven surface of the holding member 21, and in this state, the effective composition raw material 22a is crosslinked and matured to lose fluidity. It is transformed into the softening composition 22 in the softening state. In this way, a patch is formed in which the softening composition 22 in a soft state is bonded to the holding member 21 without being peeled off.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

In the method of manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect B] and [Method Effect A] are obtained. Effect C], [Method Effect Kuke], [Method Effect C-a], [Method Effect C-a], [Method Effect C-b], [Composition Effect A], [Composition Effect C], [Construction Effect Cuke ], [construction effect s], [construction effect co-a], etc. are obtained.

In the aforementioned step (C) of the present embodiment, the same effect as described above can be obtained even when the inside of the vacuum packaging apparatus is evacuated to a reduced pressure state of about 500 mmHg. Also, the same effect as described above can be obtained with a configuration in which the inside of the vacuum packaging apparatus is decompressed to a decompressed state of about 30 mmHg.

(Typical Example 2-2)
An example of a patch containing package comprising a water-containing gel-like softening composition exhibiting a cooling effect or a cooling effect and an analgesic and anti-inflammatory effect will be described.
In the aforementioned Typical Example 2, instead of the A1 flowing efficacy composition raw material 22a, the crosslinkable water-containing gel-like A2 flowing efficacy composition having an analgesic effect prepared in (Typical Example 1-2) was used. A composition raw material 22a is prepared.
Other steps are the same as the steps of (Typical Example 2-1) described above.
As a result, the fluidizing composition raw material 22a is matured into the flexible composition 22 having stickiness and lacking fluidity, and thus the adhesive patch 2 is equipped with a holding member, a flexible composition, and a peeling protective member. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

In the manufacturing method of the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect B] and [Method Effect] are obtained. Effect C], [Method Effect Kuke], [Method Effect C-a], [Method Effect C-a], [Method Effect C-b], [Composition Effect A], [Composition Effect C], [Construction Effect Cuke ], [Structure Effect S], [Structure Effect C], [Structure Effect C], [Method Effect S], [Structure Effect S], etc. are obtained.

(Comparative Example 2a)
In the exemplary embodiment 2-1, the following steps partially similar to the conventional manufacturing steps shown in FIG. 12 are provided instead of the respective steps.
- [step similar to step (a) in FIG. 12]:
In a room temperature atmosphere of about 25° C., the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-1) is prepared.

・[Step similar to step (b-a) in FIG. 12]:
A holding member 21 made of a needle-punched nonwoven fabric having bending flexibility, stretchability, and air humidity permeability and having a thickness of about 1 mm, a vertical width of about 50 mm, and a horizontal width of about 120 mm, containing polyethylene terephthalate fibers, other fibers, binders, etc. prepare. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids between tangled fibers and a fine uneven surface.
Separately, a peeling protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 50 mm, and a width of about 120 mm is prepared.
In a room temperature atmosphere of about 25° C., the A1 fluid efficacy composition raw material 22a prepared in step A is added to the A1 fluid efficacy composition in a state where a holding member peripheral margin 21a of about 5 mm is formed on the surface of the holding member 21. Within about 20 minutes after the preparation of the raw materials, they are transferred and laminated, and the peeling protection member 23 is laminated. In this way, the peeling protection member 23 is laminated in a state of covering the flow benefit composition raw material 22a having a thickness of about 2 mm, a length of about 40 mm, and a width of about 110 mm and the holding member peripheral margin 21a, thereby forming a holding member/benefit composition. A raw material/release protection member laminate is prepared. In this step, a plastic frame having a vertical width of about 40 mm and a horizontal width of about 110 mm is placed inside the holding member peripheral margin 21a on the surface of the holding member 21, and a fluid gel is placed inside the frame. A1 fluid efficacy composition material 22a having a thickness of about 2 mm, a vertical width of about 40 mm, and a horizontal width of about 110 mm so as to form a holding member peripheral blank portion 21a by charging the A1 fluid efficacy composition material 22a. are laminated on the surface of the holding member 21 .

・ [Steps similar to FIG. 12 (b-c) step, (c-a) step]:
While being placed in an atmosphere of about 25° C., the fluidizing composition raw material 22a is cross-linked to the softening composition 22 in a non-fluid state to be aged and changed, and the softening composition 22 is retained. It is adhered to the member 21 to form a retaining member/softening composition/peel protection member laminate in which the softening composition 22 is adhered to the retaining member 21 . As a result, the flowing effect composition raw material 22a is aged into the softening effect composition 22 to form the adhesive patch 2 having the holding member, the softening effect composition, and the peeling protection member having a changed configuration.
Here, in the holding member/flowing effect composition material/peeling protective member, as shown in FIG. Therefore, the thickness H of the fluid efficacy composition raw material 22a is reduced to a thickness H2, and the fluid efficacy composition raw material 22a protrudes from the end face of the holding member 21 by a length L2. Become.
Then, as shown in FIG. 12(c-a), with the lapse of time, the fluidizing effect composition raw material 22a is crosslinked from the fluid state to the softening effect composition 22 in a non-fluid state, and is aged and changed. At the same time, the softening composition 22 is adhered and bonded to the holding member to obtain a patch comprising a laminate of the retaining member, the softening composition and the peeling protective member in which the softening composition 22 is adhered and bonded to the holding member. Here, the protruding fluid benefit composition raw material 22a is also matured and changed from the fluid state to the flexible benefit composition 22 having adhesiveness without fluidity.

・[step similar to step (d-a) in FIG. 12]:
A film-like packaging container 3 having a thickness of about 0.1 mm or less is prepared, which is the same as that used in the exemplary embodiment 2-1, and the above ( c-b) With the patch prepared in the step placed, the opening of the packaging container 3 in a region spaced apart by about 5 mm or more from the periphery of the patch is pressed and heated by a heat sealer, The opening of the packaging container 3 is fused and joined to be sealed. In this way, a patch-containing packaged product in which the patch is stored in the packaging container 3 is obtained. Here, the packaging container 3 is not housed in a state of being in close contact with the patch.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.
That is, a patch containing package 1 in which the softening composition 22 protrudes from the end surface of the patch is obtained.

(Comparative Example 2b)
In the exemplary embodiment 2-1, the following steps partially similar to the conventional manufacturing steps shown in FIG. 12 are provided instead of the respective steps.
[Step A of Typical Example 2-1 (step corresponding to step of preparing raw material for fluid efficacy composition]: [step similar to step (a) in FIG. 12]:
In an atmosphere of room temperature of about 25° C., the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-1) is prepared.

[Step B of Typical Example 2-1 (Lamination member lamination step: a step corresponding to the step of lamination of the holding member/fluid composition raw material/peeling protective member)]: [Step similar to step (b-a) in FIG. ]:
A holding member 21 made of a needle-punched nonwoven fabric having bending flexibility, stretchability, and air humidity permeability and having a thickness of about 1 mm, a vertical width of about 50 mm, and a horizontal width of about 120 mm, containing polyethylene terephthalate fibers, other fibers, binders, etc. to prepare. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Separately, a peel protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a length of about 50 mm, and a width of about 120 mm is prepared.
In an atmosphere of room temperature of about 25° C., the A1 fluid efficacy composition raw material 22a prepared in step A is added to the A1 fluid efficacy composition in a state where a holding member peripheral blank portion 21a of about 5 mm is formed on the surface of the holding member 21. Within about 20 minutes after the preparation of the raw materials, they are transferred and laminated, and the peeling protection member 23 is laminated. In this way, the peeling protection member 23 is laminated in a state of covering the flow benefit composition raw material 22a having a thickness of about 2 mm, a length of about 40 mm, and a width of about 110 mm and the holding member peripheral margin 21a, thereby forming a holding member/benefit composition. A raw material/release protection member laminate is prepared. In this step, a plastic frame having a vertical width of about 40 mm and a horizontal width of about 110 mm is placed inside the holding member peripheral margin 21a on the surface of the holding member 21, and a fluid gel is placed inside the frame. A1 fluid efficacy composition material 22a having a thickness of about 2 mm, a vertical width of about 40 mm, and a horizontal width of about 110 mm so as to form a holding member peripheral blank portion 21a by charging the A1 fluid efficacy composition material 22a. are laminated on the surface of the holding member 21 .

・ [C: Laminate packaging step] step:
A film-like packaging container 3 having a thickness of about 0.1 mm or less, which is the same as that used in Typical Example 2-1, was prepared, and the A1 flow efficiency was measured in a room temperature atmosphere of about 25 ° C. and a normal pressure atmosphere. Within about 30 minutes after the preparation of the composition raw material, the above-mentioned holding member/effective composition raw material/peeling protective member laminate is placed in a film-like packaging container consisting of two upper and lower layers positioned in such a manner that the polyethylene layers face each other. 3, the opening of the region spaced apart by about 5 mm or more from the periphery of the holding member/effective composition raw material/peeling protective member laminate is pressed and heated by a heat sealer to form a packaging container 3. The opening of is melt-fused to join and seal. In this way, a laminate-containing packaged product is obtained in which the holding member, the effective composition raw material, and the peel-protective member laminate are hermetically housed in the packaging container 3 . Here, the packaging container 3 is not accommodated in a state in which it is in close contact with the holding member/effective composition raw material/peeling protective member laminate.

・[D: Effective composition raw material maturing step] step:
The laminate housing package prepared by the above step (C) is placed in an atmosphere of room temperature of about 25° C. for about 60 minutes or more.
While placed in an atmosphere of about 25° C., the fluidizing composition raw material 22a is cross-linked to the softening composition 22 in a non-fluid state to be aged and changed, and the softening composition 22 is retained. It is adhered to the member 21 to form a retaining member/softening composition/peel protection member laminate in which the softening composition 22 is adhered to the retaining member 21 . As a result, the flowable efficacy composition raw material 22a is matured into the softening efficacy composition 22 to form the patch 2 including the holding member, the softening efficacy composition, and the peeling protection member having a changed configuration, and the patch 2 is formed. is stored in the packaging container 3 to obtain the patch containing package 1.
Here, in the holding member/flowing effect composition material/peeling protection member, as shown in FIG. Therefore, the thickness H of the fluid efficacy composition raw material 22a is reduced to a thickness H2, and the fluid efficacy composition raw material 22a protrudes from the end face of the holding member 21 by a length L2. Become.
Then, as shown in FIG. 12(d-a), with the lapse of time, the fluid composition raw material 22a is crosslinked from the fluid state to the flexible composition 22 in the non-fluid state, and is aged and changed. At the same time, the softening composition 22 is adhered and bonded to the holding member, and the patch containing the patch comprising the holding member, the softening composition, and the peeling protective member laminate in which the softening composition 22 is adhered and bonded to the holding member. Agent 2 is obtained. Here, the protruding fluid benefit composition raw material 22a is also matured and changed from the fluid state to the flexible benefit composition 22 having adhesiveness without fluidity.
That is, a patch containing package 1 in which the softening composition 22 protrudes from the end surface of the patch is obtained.

(Comparative Example 2c)
As a packaging container, a patch storage package comprising a packaging container comprising a blister-type container body having a housing recess with an open top surface and a flange formed around the periphery of the recess and a container lid will be described. . In general, the blister-type container body is preferably made of a material designed to have mechanical strength to withstand the force applied during transportation, distribution, storage, and the like. That is, the blister-type container main body is constructed so as to have mechanical strength to withstand external pressure and be configured not to be deformed by external pressure. In this comparative example, as the blister-type container main body, a housing recess (about 55 mm in width, about 125 mm in length, and about 3 mm in depth) having an open top and a flange (about 5 mm in width of the flange) formed around the periphery of the recess were used. A blister type container made of PET (polyethylene terephthalate) having a thickness of about 0.7 mm is constructed. The size of the accommodating recess of the blister-type container is about 5 mm or more larger than the size of the holding member/effective composition raw material/peeling protective member laminate (length: about 50 mm, width: about 120 mm). As the container cover, a laminated film which is made of the same material as that of the packaging container constructed in Typical Example 2-1 and which can be heat-sealed and has flexibility to be deformed is constructed.

・[Step A: Fluid efficacy composition raw material preparation step]:
A crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-1) is prepared.
[Step B: Lamination member lamination step: Holding member/raw material for fluid composition/peel protection member lamination step]:
A holding member/effective composition raw material/peeling protective member laminate is prepared by the same steps as in (Typical Example 2-1) described above.

・ [C: Laminate packaging step] step:
In an atmosphere of room temperature of about 25° C., within about 30 minutes after the preparation of the A1 flowable efficacy composition raw material, the holding member/beneficial composition raw material/peeling protective member laminate prepared by the above step (B) is packaged. In this state, the inside of the vacuum packaging device is evacuated to a reduced pressure state of about 100 mmHg or less, and the brim of the blister type container body and the container lid are melted and fused together in the reduced pressure state. are joined and sealed. After that, the inside of the chamber is returned to normal pressure (about 760 mmHg). As a result, the periphery of the packaging container 3 is thermally fused and sealed, and a laminate containing package is prepared in which the interior of the packaging container 3 is in a decompressed state.
Here, the container lid body of the laminated product storage package formed is deformed along the shape of the holding member/effective composition raw material/peeling protection member laminate and brought into close contact. However, the blister-type container main body maintains the same shape as before vacuum sealing without deformation.

・[D: Effective composition raw material maturing step] step:
By a process similar to that of (Typical Example 2-1) described above, the laminate housing package prepared by the process (C) is placed in an atmosphere of room temperature of about 25° C. for about 60 minutes or longer. As a result, the fluidizing composition raw material 22a is matured into the flexible composition 22 having stickiness and lacking fluidity, and thus the adhesive patch 2 is equipped with a holding member, a flexible composition, and a peeling protective member. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.
At this point, the fluid composition raw material 22a protrudes from the periphery of the holding member 21, and in this protruding state, is crosslinked with the softening composition 22 and matured to form the holding member, the softening composition, and the peeling protection member. A patch containing package 1 is obtained in which the patch 2 provided with the laminate is housed in the packaging container 3 .
That is, a patch containing package 1 in which the softening composition 22 protrudes from the end surface of the patch is obtained.

(Summary of states of patch containing packages manufactured in Comparative Example 2a, Comparative Example 2b, and Comparative Example 2c)
In any of the patch containing packages of Comparative Example 2a, Comparative Example 2b, and Comparative Example 2c, the flexible and beneficial composition between the holding member and the peeling protective member There is a tendency for defects to be produced in which the patch protrudes from the edge of the gap. When the adhesive patch that constitutes the protruding functional softening composition is placed in a packaging container, the protruding functional softening composition adheres to the inner surface of the packaging container, making it easy to remove the patch from the packaging container. There is a tendency for the inconvenience of not having one. Furthermore, when the patch is attached to the human skin, the protruding softening composition exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, and the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, there is a tendency that a portion of the back side of the holding member is sticky, giving an unpleasant feeling.

(Typical Example 3-1)
Manufacture of a patch storage package containing a water-containing gel-like softening composition:
A typical example of a method for manufacturing a patch containing package including a step of cooling the effective composition raw material shown in FIG. 2 will be described.

・[Step A: Fluid efficacy composition raw material preparation step]:
A water-containing gel-like crosslinkable A1 flow benefit composition raw material 22a prepared in (Typical Example 1-1) is prepared. In a room temperature atmosphere of about 25° C., the hydrous gel-like A1 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 40 mm, a width of about 110 mm, and a height of about 2 mm or more so that the thickness is about 2 mm. put into
・[(A) Cooling predetermined shape forming step]:
The polystyrene container containing the fluid efficacy composition raw material 22a is cooled to a temperature of about -10°C to about 3°C where the fluid efficacy composition raw material 22a is in a non-deformed state, and the fluid efficacy composition raw material 22a is cooled to a non-deformed state. It is prepared as a raw material 22b. As a result, a cooled non-deformed effective composition material 22b in a non-deformed state having a thickness of about 2 mm, a vertical width of about 40 mm and a horizontal width of about 110 mm is prepared.

[Step B: Laminating member laminating step: Holding member/raw material for cooling non-deforming effect composition/peeling protective member laminating step]:
As shown in FIG. 2A, a peeling protection member 23 made of polypropylene having a thickness of 0.1 mm or less, a vertical width of approximately 50 mm, and a horizontal width of approximately 120 mm is separately prepared.
In an atmosphere of room temperature of about 25° C., the cooled non-deformable effective composition raw material 22b prepared in the above step A is laminated in a state where the holding member peripheral margin 21a of about 5 mm is formed on the surface of the holding member 21, The peel protective member 23 is laminated so as to cover the cooled non-deformed effective composition raw material 22b and the holding member peripheral margin 21a, thus preparing a holding member/effective composition raw material/peeling protective member laminate. Here, the cooled non-deformed benefit composition material 22b maintains the non-deformed state.

・ [C: Laminate packaging step] step:
As shown in FIG. 2(B), a sample containing polyethylene terephthalate fibers, other fibers, a binder, etc., having a thickness of about 1 mm, a vertical width of about 50 mm, and a horizontal width of about 120 mm, has bending flexibility, stretchability, and air humidity. A holding member 21 made of a permeable needle-punched nonwoven fabric is prepared. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids and fine uneven surfaces between entangled fibers.
Also, a film-like packaging container 3 having a thickness of about 0.1 mm or less, which is composed of three layers of a polyethylene film, an aluminum foil, and a polyethylene terephthalate film, is prepared. Here, the film-like packaging container 3 has a state in which its circumference is opened.
The non-deformable cooling effect composition raw material 22b and the peeling protection member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peeling protection member 23 positioned on the surface side to form the holding member/effective composition raw material/peeling. A protective member laminate is prepared. Here, the cooled non-deformed benefit composition raw material 22b maintains the non-deformed state.
Separately, prepare a vacuum packaging device (not shown) that is equipped with a vacuum pump and a heat sealing device inside the chamber and that can reduce the pressure inside the chamber.
In an atmosphere of room temperature of about 25° C., the holding member/effective composition raw material/peeling protective member laminate is placed between two upper and lower film-like packaging containers 3 positioned with the polyethylene layers facing each other. In this state, the inside of the vacuum packaging device was evacuated to a reduced pressure state of about 100 mmHg or less, and a space of about 5 mm or more was provided from the periphery of the holding member/effective composition raw material/peeling protective member laminate in the reduced pressure state. The opening of the region is pressed and heated by a heat sealer, and the opening of the packaging container 3 is fused and welded to be sealed.
After that, the inside of the chamber is returned to normal pressure (about 760 mmHg). As a result, the periphery of the packaging container 3 is heat-sealed, and the interior of the packaging container 3 is decompressed, and the holding member, the ingredient of the efficacy composition, and the peeling of the ingredients contained in the packaging container 3 are peeled off. In a state where the protective member laminate is positioned in the packaging container 3, the packaging container 3 is deformed along the shape of the holding member, the active composition raw material, and the peeling protective member laminate and is in a state of close contact. A product storage package is prepared. That is, due to the pressure difference between the inside and the outside of the packaging container, the packaging container 3 is deformed along the shape of the holding member/effective composition raw material/peeling protective member laminate and adheres to the laminate. product is obtained.
In this state, the peel protection member 23 covers the surface and edges of the cooling non-deformable effective composition raw material 22b and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in contact with the holding member. - A laminate-containing packaging product can be obtained that deforms along the shape of the active composition raw material/peel protection member laminate and adheres to the laminate. Here, the cooled non-deformed benefit composition material 22b maintains the non-deformed state.

・[D: Effective composition raw material maturing step] step:
As shown in (D) of FIG. 2, the laminate housing package prepared in the step (C) is placed in an atmosphere of room temperature of about 25° C. for about 60 minutes or more.
In a state of being placed in an atmosphere of about 25°C, the cooled non-deformed effect composition raw material 22b constituting the laminate storage package becomes non-fluid and flexible during the process of raising the temperature to about 25°C and at about 25°C. A holding member in which the softening composition 22 is crosslinked and aged and changed, and the softening composition 22 is adhered and joined to the holding member 21, and the softening composition 22 is adhered and joined to the holding member 21. A benefit composition-release protection member laminate is formed. As a result, the cooled non-deformable effect composition raw material 22b is matured into the softening effect composition 22 that has stickiness and no fluidity, and has a changed structure. A patch-containing package 1 is obtained in which the patch 2 is formed and the patch 2 is stored in the packaging container 3 .
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

Here, the packaging container 3 is kept in close contact with the surface and edges of the cooled non-deformed effective composition raw material 22b and the peripheral margin 21a of the holding member 21 via the peel protection member 23. A patch containing package 1 in which a raw material is crosslinked with a softening effect composition 22 and aged, and the patch 2 provided with a holding member/softening effect composition/peeling protection member laminate is housed in a packaging container 3. is obtained. That is, the peel protection member 23 covers the surface and edges of the flexible composition 22 and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in a state where the holding member and the flexible composition are in close contact. It is possible to obtain an adhesive patch storage package that is deformed along the shape of the object/peeling protective member laminate and adheres to the laminate. In particular, the softening composition 22 is adhered to the surface of the holding member 21 while forming the peripheral margin 21a of the holding member 21 without protruding from the surface of the holding member 21, thereby obtaining a patch containing package.

In addition, due to the pressure difference between the inside and the outside of the packaging container, the cooling non-deformable effective composition raw material 22b adhering to the surface of the holding member 21 made of nonwoven fabric having a fine uneven surface is removed through the peeling protection member 23. The holding member 21 and the cooled non-deformed effective composition raw material 22b are sandwiched between the film-like packaging containers located on the front side and the back side of the holding member/effective composition raw material/peeling protective member laminate. are pressed against each other. During the process of raising the temperature to about 25° C. and at about 25° C., the cooled non-deformed beneficial composition raw material 22 b changes into the form of the beneficial composition raw material 22 a having flowability, and part of the beneficial composition raw material 22 a is attached to the holding member 21 . A state is formed in which the material enters into the unevenness of the surface of the fine unevenness, and in this state, the ingredients of the benefit composition are crosslinked and matured to change into the softening benefit composition 22 in a flexible state without fluidity. In this way, a patch is formed in which the softening composition 22 in a soft state is joined to the holding member 21 without being peeled off.

In the manufacturing method of the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect C] and [Method Effect C] are obtained. Effect C], [Method Effect Co-a], [Method Effect C], [Construction Effect C], [Construction Effect C], [Construction Effect C], [Construction Effect C-a], etc. be done.

In the aforementioned step (C) of the present embodiment, the same effect as described above can be obtained even when the inside of the vacuum packaging apparatus is evacuated to a reduced pressure state of about 500 mmHg. Also, the same effect as described above can be obtained with a configuration in which the inside of the vacuum packaging apparatus is decompressed to a decompressed state of about 30 mmHg.

(Typical Example 3-2)
An example of a patch containing package comprising a water-containing gel-like softening composition exhibiting a cooling effect or a cooling effect and an analgesic and anti-inflammatory effect will be described.
In the exemplary embodiment 3-1 described above, instead of the A1 fluid efficacy composition raw material 22a,
Prepare the crosslinkable water-containing gel-like A2 fluid effective composition raw material 22a having an analgesic effect prepared in (Typical Example 1-2).
The other steps comprise the same steps as those of (Exemplary Example 3) described above.
As a result, the adhesive patch 2 provided with the holding member, the softening composition, and the peeling protection member, which has a configuration changed by maturing the fluid composition raw material 22a into the flexible composition 22 having stickiness and no fluidity. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.

In the manufacturing method of the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and [Method Effect C] and [Method Effect C] are obtained. Effect C], [Method Effect Co-a], [Method Effect C], [Construction Effect C], [Construction Effect C], [Construction Effect C], [Construction Effect C-a], and [Method Effect C ], [Construction Effect], etc. are obtained.

(Comparative Example 3)
A patch containing package containing a patch is prepared by the same manufacturing method as in Comparative Examples 2a and 2b.
As a result, in any of the patch containing packages, a patch was produced in which the softening composition composed between the holding member and the peeling protective member protruded from the edge between the holding member and the peeling protective member. There will be a defect that it will be done. When the patch comprising the protruding composition for softening is placed in a packaging container, the composition for softening that protrudes adheres to the inner surface of the packaging container, making it easy to remove the patch from the packaging container. There is an inconvenience that there is no Furthermore, when the patch is attached to the human skin, the protruding softening composition exhibits stickiness. The unsupported portion of the softening composition that protrudes and is exposed comes into contact with clothing, causing the adhesive patch to adhere to the clothing, or the protruding portion of the softening composition is exposed on the back side of the holding member. As a result, a part of the back side of the holding member becomes sticky, giving an unpleasant feeling.

(Typical Example 4-1)
Manufacture of a patch storage package containing a water-containing gel-like softening composition:
A typical example of a method for manufacturing a patch containing package comprising the steps of cooling and cutting the effective composition raw material shown in FIG. 3 will be described. The manufacturing method of the adhesive patch containing package of the present embodiment includes the following steps.

[Step A: step of preparing raw material for fluid efficacy composition and step of forming predetermined shape by cooling and cutting]:
As shown in FIG. 3(A), the crosslinkable water-containing gel-like A1 fluid efficacy composition raw material 22a prepared in (Typical Example 1-1) is prepared. In a room temperature atmosphere of about 25° C., the hydrous gel-like A1 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 120 mm, a width of about 330 mm, and a height of about 2 mm or more so that the thickness is about 2 mm. put into
As shown in FIG. 3(A), the flow benefit composition raw material 22a placed in a polystyrene container is cooled to a second cooling non-deformation temperature of about -10 to about 3° C. where it is in a non-deformed state. , forming a cooled non-deformed benefit composition raw material in a non-deformed state, and then cutting the cooled non-deformed benefit composition raw material 22b into a plurality of (nine) predetermined shapes (length about 40 mm, width about 110 mm). , a substantially rectangular sheet with a height of about 2 mm) is prepared.
In this step, a double-edged die with a tip edge angle of 30 degrees and a height of about 5 mm is mounted on the upper plate of the flat plate cutting device, and the cooled non-deformable effective composition raw material 22b in the cooled state is cut into the flat plate cutting device. The upper plate is operated to cut the cooled non-deformed effect composition raw material 22b to obtain the cut cooled non-deformed effect composition raw material 22c in the form of a rectangular sheet.
At the time of cutting, the cooled non-deformed benefit composition raw material 22b is cut without flowing or deformed to obtain the desired cut cooled non-deformed benefit composition raw material 22c in the desired sheet-like rectangular shape which is accurately separated. rice field. That is, the cut and cooled non-deformed effective composition raw material 22c having a desired shape with high accuracy in desired thickness, area, shape, weight, etc. was obtained. In addition, deposits such as residues of the cooling non-deformable composition were not observed on the cutting edge of the press-cutting blade after the cutting operation.

・ [B process: Lamination member lamination process]:
As shown in FIG. 3B, a holding member 21 made of the same nonwoven fabric as the holding member made of nonwoven fabric constructed in the exemplary embodiment 3-1, and a peel protection member 23 are prepared.
The cut and cooled non-deformable effective composition raw material 22c prepared in step A is layered on the surface of the retaining member 21 while forming a marginal portion 21a on the periphery of the retaining member 21 with a thickness of about 5 mm. The peeling protective member 23 is laminated so as to cover the substance 22c and the holding member peripheral margin 21a, and thus the holding member/effective composition raw material/peeling protective member laminate is prepared. Here, the cut-cooled non-deformed benefit composition raw material 22c maintains the non-deformed state.

・ [C: Laminate packaging step] step:
As shown in FIG. 3(C), a flexural flexibility, stretchability, and air humidity of about 1 mm in thickness, about 50 mm in length, and about 120 mm in width containing polyethylene terephthalate fibers, other fibers, binders, etc. A holding member 21 made of a permeable needle-punched nonwoven fabric is prepared. From the viewpoint of the fine structure, the holding member made of nonwoven fabric has countless fine voids between tangled fibers and a fine uneven surface.
Also, a film-like packaging container 3 having a thickness of about 0.1 mm or less, which is composed of three layers of a polyethylene film, an aluminum foil, and a polyethylene terephthalate film, is prepared. Here, the film-like packaging container 3 has a state in which its circumference is opened.
The cut and cooled non-deformed effective composition raw material 22c and the peel protective member 23 are laminated on a predetermined position area on the surface of the holding member 21 with the peel protective member 23 positioned on the surface side to form a holding member/effective composition raw material/ A peel protection member laminate is prepared. Here, the cut-cooled non-deformed benefit composition raw material 22c maintains the non-deformed state.
Separately, prepare a vacuum packaging device (not shown) which is equipped with a vacuum pump and a heat sealing device inside the chamber and which can reduce the pressure inside the chamber.

In an atmosphere of room temperature of about 25° C., the holding member/effective composition raw material/peeling protective member laminate is placed between two upper and lower film-like packaging containers 3 positioned with the polyethylene layers facing each other. In this state, the inside of the vacuum packaging device was evacuated to a reduced pressure state of about 100 mmHg or less, and a space of about 5 mm or more was provided from the periphery of the holding member/effective composition raw material/peeling protective member laminate in the reduced pressure state. The opening of the region is pressed and heated by a heat sealer, and the opening of the packaging container 3 is fused and welded to be sealed.
After that, the inside of the chamber is returned to normal pressure (about 760 mmHg). As a result, the periphery of the packaging container 3 is heat-sealed, and the interior of the packaging container 3 is decompressed, and the holding member, the ingredient of the efficacy composition, and the peeling of the ingredients contained in the packaging container 3 are peeled off. In a state where the protective member laminate is positioned in the packaging container 3, the packaging container 3 is deformed along the shape of the holding member, the active composition raw material, and the peeling protective member laminate and is in a state of close contact. A product storage package is prepared. That is, due to the pressure difference between the inside and the outside of the packaging container, the packaging container 3 is deformed along the shape of the holding member/effective composition raw material/peeling protective member laminate and adheres to the laminate. product is obtained.
In this state, the peel protection member 23 covers the surface and edges of the cut and cooled non-deformable effective composition raw material 22c and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is held. It is possible to obtain a laminate-containing packaging product that deforms along the shape of the laminate of the member, the raw material of the efficacy composition, and the peeling protective member and adheres to the laminate. Here, the cut-cooled non-deformed benefit composition raw material 22c maintains the non-deformed state.

・ [D: Ingredient aging step for efficacy composition] step:
As shown in (D) of FIG. 3, the laminate housing package prepared in the step (C) is placed in an atmosphere of room temperature of about 25° C. for about 60 minutes or more.
While being placed in an atmosphere of about 25°C, the cut-cooled non-deformed active composition raw material 22c that constitutes the laminate storage package loses fluidity during the process of raising the temperature to about 25°C and at about 25°C. A holding member in which the softening composition 22 in a soft state is crosslinked, aged and changed, and the softening composition 22 is adhered and joined to the holding member 21, and the softening composition 22 is adhered and joined to the holding member 21. A softening benefit composition/release protection member laminate is formed. As a result, the cut-cooled non-deformable benefit composition raw material 22c is matured into the softening benefit composition 22 having stickiness and no fluidity, thereby providing a holding member, a softening benefit composition, and a peel protection member having changed configurations. A patch containing package 1 is obtained in which the patch 2 is formed and the patch 2 is housed in the packaging container 3 .
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

Here, the packaging container 3 is kept in close contact with the surface and edges of the cut and cooled non-deformed active composition raw material 22c and the peripheral margin 21a of the holding member 21 via the peel protection member 23. A patch containing package product in which the patch 2 having a holding member, a softening composition and a peel protection member laminate is stored in a packaging container 3. 1 is obtained. That is, the peel protection member 23 covers the surface and edges of the flexible composition 22 and is in close contact with the peripheral blank portion 21a of the holding member 21, and the packaging container 3 is in a state where the holding member and the flexible composition are in close contact. It is possible to obtain an adhesive patch storage package that is deformed along the shape of the object/peeling protective member laminate and adheres to the laminate. In particular, the softening composition 22 is adhered to the surface of the holding member 21 while forming the peripheral margin 21a of the holding member 21 without protruding from the surface of the holding member 21, thereby obtaining a patch containing package.

In addition, due to the pressure difference between the inside and outside of the packaging container, the cut cooling non-deformable effective composition raw material 22c adhering to the surface of the holding member 21 made of nonwoven fabric having a finely uneven surface peels off the peeling protective member 23. The holding member 21 and the cut/cooled undeformed beneficial composition are sandwiched between the film-like packaging containers positioned on the front side and the back side of the holding member/beneficial composition raw material/peeling protective member laminate via the holding member 21. The raw material 22c is pressurized against each other. During the process of raising the temperature to about 25° C. and at about 25° C., the cut-cooled non-deformed benefit composition raw material 22 c changes into the form of the beneficial composition raw material 22 a having flowability, and a part of the beneficial composition raw material 22 a is held by the holding member 21 . In this state, the ingredients of the benefit composition are crosslinked and matured to change into the softening benefit composition 22 in a flexible state without fluidity. In this way, a patch is formed in which the softening composition 22 in a soft state is joined to the holding member 21 without being peeled off.

In the method for manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and the aforementioned [Method Effect D] and [ Method Effect C], [Method Effect Kuke], [Method Effect C-a], [Method Effect S], [Method Effect S-a], [Method Effect S], [Composition Effect D], [Construction Effect C] , [Construction Effect Kuke], [Construction Effect S], [Construction Effect S], [Construction Effect Co-a], etc. can be obtained.

In the aforementioned step (C) of the present embodiment, the same effect as described above can be obtained even when the inside of the vacuum packaging apparatus is evacuated to a reduced pressure state of about 500 mmHg. Also, the same effect as described above can be obtained with a configuration in which the inside of the vacuum packaging apparatus is decompressed to a decompressed state of about 30 mmHg.

(Typical Example 4-2)
An example of a patch containing package comprising a water-containing gel-like softening composition exhibiting a cooling effect or a cooling effect and an analgesic and anti-inflammatory effect will be described.
In the exemplary embodiment 4-1 described above, instead of the A1 fluid efficacy composition raw material 22a,
Prepare the crosslinkable water-containing gel-like A2 fluid effective composition raw material 22a having an analgesic effect prepared in (Typical Example 1-2).
The other steps are the same as the steps of (Typical Example 4-1) described above.
As a result, the fluidizing composition raw material 22a is matured into the flexible composition 22 having stickiness and lacking fluidity, and thus the adhesive patch 2 is equipped with a holding member, a flexible composition, and a peeling protective member. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.

In the method for manufacturing the patch containing packaged product of the present embodiment or the patch containing packaged product of the present embodiment, the aforementioned [Method Effect A] and [Constructive Effect A] are obtained, and the aforementioned [Method Effect D] and [ Method Effect C], [Method Effect Kuke], [Method Effect C-a], [Method Effect S], [Method Effect S-a], [Method Effect S], [Composition Effect D], [Construction Effect C] , [Construction Effect], [Construction Effect S], [Construction Effect], [Construction Effect Co-a], and [Method Effect C], [Construction Effect C], etc. can be obtained.

(Typical Example 4-3)
In [Step A: Predetermined shape forming step by cooling cutting] of the above-described exemplary embodiment 4-1,
The flowing benefit composition raw material 22a contained in a polystyrene container is cooled to a second cooling non-deformed temperature of about -10°C to about 3°C to produce a cooled non-deformed benefit composition in a non-deformed state. Forming a feedstock 22b and then cutting the cooled undeformed benefit composition feedstock 22b into cut and cooled shapes as shown in Figures 7A, 7B, 7C or 7D. A step of preparing a non-transforming benefit composition ingredient 22c is also possible.
In this case, the holding member 21 and the peeling protective member 23 are constituted by the holding member 21 and the peeling protective member 23 having a shape similar to that of the cut-cooled non-deforming active composition material 22c.
10C and 10D, in the case of preparing the cut and cooled undeformed beneficial composition raw material 22c having through-holes, the holding member 21 is also cut and cooled undeformed beneficial composition raw material 22c. formed into a shape having the same through-hole as
Other steps are similar to those of typical example 4-1 described above. As a result, the patch containing package 1 in which the patch 2 is contained in the packaging container 3 is obtained.

In this embodiment, the same effect as the above (Typical Embodiment 4-1) can be obtained.

(Typical Example 4-4)
A water-containing gel-like A1 flow benefit composition raw material 22a having crosslinkability prepared in (Typical Example 1-1) is prepared.
In a room temperature atmosphere of about 25° C., the hydrous gel-like A1 fluid efficacy composition raw material 22a is placed in a polystyrene container having a length of about 110 mm, a width of about 50 mm, and a height of about 40 mm or more to a thickness of about 40 mm. be put in.
The following steps are provided in place of [Step A: Predetermined shape forming step by cooling cutting] of the aforementioned exemplary embodiment 4-1.
The flowable effect composition raw material 22a contained in a polystyrene container is cooled to a second cooling non-deformation temperature of about -10 to about 3°C, which is a non-deformed state, and the cooled non-deformed effect in the non-deformed state A composition raw material is formed, and then the cooled non-deformable effective composition raw material 22b is cut at intervals of about 2 mm to form a plurality of (25) predetermined shapes (length about 40 mm, width about 110 mm, height about 2 mm). ) to prepare cut cooled non-deformed benefit composition raw material 22c.
As a method for cutting the cooled non-deformable efficacy composition raw material 22b, cutting by using a blade similar to a kitchen knife or cutting by a wire can be implemented.
The other steps are the same as the steps of (Typical Example 4-1) described above.
As a result, the fluidizing composition raw material 22a is matured into the flexible composition 22 having stickiness and lacking fluidity, and thus the adhesive patch 2 is equipped with a holding member, a flexible composition, and a peeling protective member. is formed, and the patch containing package 1 in which the patch 2 is stored in the packaging container 3 is obtained.
In this way, a patch containing package containing a patch having a length of about 50 mm and a width of about 120 mm is obtained.

In this embodiment, the same effect as the above (Typical Embodiment 4-1) can be obtained.

(Comparative Example 4)
In the [Step A: Predetermined shape forming step by cooling cutting] of Typical Example 4-1 described above, the length of about 120 mm, width of about 330 mm, A water-containing gel-like A1 flowing efficacy composition raw material 22a having a thickness of about 2 mm is cut into a length of about 40 mm, a width of about 110 mm, and a height of about 2 mm using a kitchen knife blade or a pressing blade without cooling. As a result of performing the cutting operation so as to form the material raw material 22c, after the cutting operation, the fluid efficacy composition raw material is immediately fluidized and deformed, and the cut fluid efficacy composition raw material is mixed with each other again, so that it can be cut accurately. I didn't.
Further, after the cutting operation, a large amount of residue of the fluid efficacy composition raw material adhered to the cutting edge of the press cutting blade 7 .
That is, in the method of this comparative example, there is a problem in manufacturing a patch containing package having a desired shape.

(Typical Example 5)
In the aforementioned Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1, the following steps are provided in place of step (D) in each example.
(D) Step: The laminate housing package prepared in the (C) step is placed in a room temperature atmosphere of about 50° C. for about 30 to 40 minutes. After that, it is placed in a room temperature atmosphere of about 25°C.
In a state of being placed in an atmosphere of about 30° C., the effect composition raw material 22c constituting the laminate storage package is heated to about 50° C. The holding member/softening composition in which the softening composition 22 is adhered and bonded to the holding member 21 and the softening composition 22 is adhered and bonded to the holding member 21 while the composition 22 is crosslinked and aged to change. • A peel protection member laminate is formed. As a result, the patch 2 including the holding member, the softening composition, and the peeling protection member, which has a configuration changed by maturing the efficacy composition raw material 22c into the flexible efficacy composition 22 having stickiness and lacking fluidity, is obtained. A patch-containing package 1 in which the patch 2 is stored in a packaging container 3 while being formed is obtained.
Other steps are the same as the above-described Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1.
As a result, the aforementioned method effect a, method effect co-a, composition effect a, composition effect co-a, and other effects can be obtained, and at the same time, the effect of significantly shortening the time required to manufacture the patch containing package product. is obtained.

(Typical Example 6)
In the aforementioned Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1, the following steps are provided in place of step (C) in each example.
・ [C: Laminate packaging step] step:
As shown in FIG. 1C, it consists of three layers of polyethylene film (about 40 μm thick), aluminum foil (about 9 μm thick), and white kraft paper (about 50 μm thick). A film-like packaging container 3 having a thickness of approximately 0.10 mm (thickness of approximately 100 μm) bonded with a thick adhesive is prepared.
Other steps are the same as the above-described Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1.
This provides the same effect as the respective exemplary embodiment described above.

(Exemplary Example 7)
In the aforementioned Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1, the following steps are provided in place of step (C) in each example.
[C: Laminate packaging step] step: As shown in (C) of FIG. A film-like packaging container 3 having a thickness of approximately 0.07 mm (thickness of approximately 70 μm) is prepared by bonding each layer with an adhesive having a thickness of several μm.
Other steps are the same as the above-described Typical Example 2-1, Typical Example 3-1, and Typical Example 4-1.
This provides the same effect as the respective exemplary embodiment described above.

According to the method for manufacturing a patch-containing package according to the present invention, a step of manufacturing a patch in which a holding member, a matured flexible active substance, and a peel-off protective member are laminated, and a step of storing the patch in a storage container. It is possible to form a patch having an aged water-containing gel-like softening composition in a packaging container without going through both steps, and the aged water-containing gel-like softening composition. As a result, the manufacturing process can be significantly simplified, the mass productivity can be improved, and the cost can be significantly reduced. The effect of being able to manufacture packaged goods can be obtained. In addition, since the softening effect composition in the form of a water-containing gel is aged while being stored in the packaging container, the time from the production of the patch to the storage in the packaging container is shortened. As a result, changes in composition and chemical deterioration due to alteration and deterioration of ingredients contained in the water-containing gel-like softening composition during the manufacturing process due to evaporation and emission of ingredients or chemical reactions with air are suppressed. A patch having stable quality is obtained.
Furthermore, in a state in which the packaging container is deformed along the shape of the holding member/effective composition raw material/peeling member laminate and brought into close contact, the fluid effective composition raw material having a flowable state does not have fluidity. A fluid efficacy composition in which the shape of the fluid efficacy composition raw material is maintained during aging and is sandwiched between the holding member and the peel protection member because it is aged and changed into a flexible efficacy composition in the form of a water-containing gel in a soft state. It is possible to prevent the raw material from protruding from between the holding member and the peeling protection member. As a result, the sticking-out softening composition sticks to the inner surface of the packaging container, and the inconvenience of not being able to easily remove the patch from the packaging container is eliminated. Furthermore, when the patch is attached to the skin of the human body, the user's discomfort caused by the stickiness of the surface of the patch due to the softening composition protruding from the adhesive not being supported by the holding member can be eliminated. , comfortable to use.

In the patch containing package of the present invention, the patch is positioned in the packaging container and the packaging container is in close contact along the shape of the patch, and the softening composition is non-fluid. Evaporation and emission of the components contained in the softening effect composition by the composition having a matured form that has been aged in the form of a water-containing gel-like softening effect composition that has a softening state that has been changed into a shape. Alternatively, changes in the composition of the contained components and chemical deterioration due to alteration and deterioration of the contained components due to chemical reactions with air are suppressed, and an effect of obtaining patch containing packages having stable quality can be obtained.
Furthermore, in order to provide a configuration in which the shape of the fluid efficacy composition raw material is maintained during aging, the space between the holding member for the fluid efficacy composition raw material and the peel protection member sandwiched between the holding member and the peel protection member. is prevented from escaping from the As a result, the protruding water-containing gel-like softening composition adheres to the inner surface of the packaging container, and the inconvenience of not being able to easily remove the patch from the packaging container is eliminated. Furthermore, when the patch is applied to the skin of the human body, the user's discomfort due to stickiness of the softening composition protruding from the surface or side of the holding member is eliminated. , a patch storage package that can be used comfortably is obtained.

1 Patch containing package 2 Patch 21 Holding member 21a Holding member peripheral margin 22 Softening effect composition, water-containing gel-like soft effect composition 22a Effective composition raw material, fluid effective composition raw material,
22b Effective composition raw material, cooled non-deformed effective composition raw material 22c Effective composition raw material, cut cooled non-deformed effective composition raw material 23 Peel protection member 3 Packaging container 3a Packaging container sealing portion 3c Heat-shrinkable packaging container

Claims (10)

(a) a sheet-shaped holding member, a softening composition adhered to and laminated on the holding member, and a sheet-shaped sheet laminated on the surface of the softening composition so as to be peelable during use. and (b) a packaging container containing the patch. A patch in which the peel protective member is removed from the patch that is taken out from the packaging container, and the softening composition laminated and bonded to the holding member is attached to the skin of a human body for use. A method for manufacturing an agent containing package, comprising:
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening effect composition is prepared from a flowable effect composition raw material containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent. The molecules are chemically crosslinked into a three-dimensional structure and have the property of maturing into a water-containing gel-like softening composition having stickiness and flexibility without fluidity,
(A) preparing an effective composition ingredient containing at least water, a crosslinkable water-soluble polymer, and a crosslinker;
Here, the said benefit composition material is a fluid benefit composition material having a flowable fluid state,
(B) In a state in which the fluidizing effect composition raw material is positioned in a region inside the periphery of the surface of the holding member to form a peripheral blank portion of the holding member, the flowing effect composition raw material is placed in a predetermined position region on the surface of the holding member. laminating member lamination step of laminating the effective composition raw material and the peel protective member in a state where the peel protective member is positioned on the surface side to prepare a holding member/effective composition raw material/peeling protective member laminate;
Here, the fluid efficacy composition raw material has a predetermined shape and fluidity,
(C) The holding member/effective composition raw material/peeling protective member laminate is placed in the packaging container, and the pressure inside the packaging container is reduced to a level lower than atmospheric pressure. A laminate packaging step of sealing the opening of the packaging container to prepare a laminate storage package in which the inside of the packaging container is formed in a reduced pressure state lower than atmospheric pressure;
Here, the fluid efficacy composition raw material has a predetermined shape and maintains fluidity,
As a result, the peeling protection member covers the surface and the edge of the fluid efficacy composition raw material and is in close contact with the holding member peripheral margin of the holding member,
The packaging container deforms along the shape of the holding member / effective composition raw material/peeling protective member laminate due to the pressure difference between the inside and the outside of the packaging container, and is in a state of close contact. A package is obtained,
as well as,
(D) aging the flowable composition raw material constituting the laminate housing package into a flexible composition in a non-fluid state, and adhering and bonding the flexible composition to the holding member to obtain a flexible composition; an aging step of preparing a holding member/flexible benefit composition/peeling protective member laminate in which the benefit composition is adhered and bonded to the holding member;
Here, the crosslinkable water-soluble The polymer is cross-linked by chemical reaction with the cross-linking agent, and the raw material for the fluid benefit composition is matured into a water-containing gel-like softening effect composition having stickiness and flexibility without fluidity,
As a result, the peeling protection member covers the surface and edges of the softening composition and adheres thereto, and adheres to the margin around the holding member of the holding member,
The packaging container is in a state of being deformed and in close contact with the holding member/softening composition/peeling protective member laminate along the shape,
A patch comprising a holding member, a softening composition, and a peeling protective member is formed in which the softening composition does not protrude from the surface of the holding member and a margin around the holding member is formed, and the patch comprises: A patch containing packaged product in which the agent is contained in the packaging container is obtained.
A method for manufacturing an adhesive patch containing package, characterized by: (a) a sheet-shaped holding member, a softening composition adhered to and laminated on the holding member, and a sheet-shaped sheet laminated on the surface of the softening composition so as to be peelable during use. and (b) a packaging container containing the patch. A patch in which the peel protective member is removed from the patch that is taken out from the packaging container, and the softening composition laminated and bonded to the holding member is attached to the skin of a human body for use. A method for manufacturing an agent containing package, comprising:
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening effect composition is prepared from a flowable effect composition raw material containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent. The molecules are chemically crosslinked into a three-dimensional structure and have the property of maturing into a water-containing gel-like softening composition having stickiness and flexibility without fluidity,
(A) A benefit composition raw material preparation step of preparing a benefit composition raw material containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent , wherein the efficacy composition raw material preparation step comprises at least water and a crosslinkable A fluid efficacy composition raw material preparation step for preparing a fluid efficacy composition raw material having a flowable fluid state containing a water-soluble polymer and a cross-linking agent,
as well as,
a cooled predetermined shape forming step of cooling the flowing benefit composition raw material to a temperature at which it becomes undeformed to prepare a cooled undeformed effective composition raw material in an undeformed state having a predetermined shape, wherein the cooled undeformed benefit composition; the raw material has a predetermined shape and maintains a non-deformed state;
(B) in a predetermined position area on the surface of the holding member, in a state in which the raw material of the cooled non-deformable benefit composition is positioned inside the periphery of the surface of the holding member to form a holding member peripheral margin, Laminating member lamination step of laminating the non-deforming cooling effect composition raw material and the peeling protective member with the peeling protective member positioned on the surface side to prepare a holding member/effective composition raw material/peeling protective member laminate. ,
wherein the cooled non-deformed beneficial composition raw material has a predetermined shape and maintains a non-deformed state,
(C) The holding member/effective composition raw material/peeling protective member laminate is placed in the packaging container, and the pressure inside the packaging container is reduced to a level lower than the atmospheric pressure. A laminate packaging step of preparing a laminate containing package in which the opening is sealed and the inside of the packaging container is formed in a reduced pressure state lower than the atmospheric pressure;
wherein the cooled non-deformed beneficial composition raw material has a predetermined shape and maintains a non-deformed state,
As a result, the peel protection member covers the surface and edges of the cooling non-deformable effective composition raw material and is in close contact with the holding member peripheral margin of the holding member,
The packaging container deforms along the shape of the holding member / effective composition raw material/peeling protective member laminate due to the pressure difference between the inside and the outside of the packaging container, and is in a state of close contact. A package is obtained,
as well as,
(D) raising the temperature of the laminate-accommodating package to ripen the efficacy composition raw materials constituting the laminate-accommodating package into a flexible efficacy composition in a flexible state without fluidity; to the holding member to prepare a holding member/softening composition/release protection member laminate in which the softening composition is adhered and joined to the holding member, wherein the release protection member is The crosslinkable water-soluble polymer reacts chemically with the crosslinker in a state where the surface and edges of the active composition raw material are covered and adhered to each other and the holding member is kept in close contact with the peripheral margin of the holding member. Crosslinked by reaction, the ingredients of the efficacy composition are matured into a water-containing gel-like softening efficacy composition having stickiness and flexibility without fluidity,
As a result, the peeling protection member covers the surface and edges of the softening composition and adheres thereto, and adheres to the margin around the holding member of the holding member,
A state in which the packaging container is deformed along the shape of the holding member/flexible benefit composition/peeling protective member laminate and adheres thereto,
forming a patch comprising a holding member, a softening composition, and a peeling protective member in which the softening composition does not protrude from the surface of the holding member and forms a margin around the holding member; A patch containing packaged product in which the agent is contained in the packaging container is obtained.
A method for manufacturing an adhesive patch containing package, characterized by: (a) a sheet-shaped holding member, a softening composition adhered to and laminated on the holding member, and a sheet-shaped sheet laminated on the surface of the softening composition so as to be peelable during use. and (b) a packaging container containing the patch. A patch in which the peel protective member is removed from the patch that is taken out from the packaging container, and the softening composition laminated and bonded to the holding member is attached to the skin of a human body for use. A method for manufacturing an agent containing package, comprising:
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening effect composition is prepared from a flowable effect composition raw material containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent. The molecules are chemically crosslinked into a three-dimensional structure and have the property of maturing into a water-containing gel-like softening composition having stickiness and flexibility without fluidity,
(A) A benefit composition raw material preparation step of preparing a benefit composition raw material containing at least water, a crosslinkable water-soluble polymer, and a cross-linking agent , wherein the efficacy composition raw material preparation step comprises at least water and a crosslinkable A fluid efficacy composition raw material preparation step for preparing a fluid efficacy composition raw material having a flowable fluid state containing a water-soluble polymer and a cross-linking agent,
as well as,
The flowing benefit composition material is cooled to a temperature at which it becomes non-deformed to prepare a non-deformed cooled non-deformed benefit composition material having a predetermined shape, and then the cooled non-deformed benefit composition material is formed into a predetermined shape. Predetermined shape forming step of cutting to prepare a cut cooling undeformed effective composition raw material;
(B) in a predetermined position area on the surface of the holding member, in a state in which the cut cooling non-deforming effective composition raw material is positioned inside the periphery of the surface of the holding member to form a holding member peripheral margin; a laminated member for preparing a holding member/effective composition raw material/peeling protective member laminate by laminating the cutting/cooling non-deformable effective composition raw material and the peelable protective member with the peelable protective member positioned on the surface side; lamination process,
wherein the cut-cooled non-deformed benefit composition raw material has a predetermined shape and maintains a non-deformed state,
(C) The holding member/effective composition raw material/peeling protective member laminate is placed in the packaging container, and the pressure inside the packaging container is reduced to a level lower than the atmospheric pressure. A laminate packaging step of preparing a laminate containing package in which the opening is sealed and the inside of the packaging container is formed in a reduced pressure state lower than the atmospheric pressure;
Here, the cut-cooled non-deformed benefit composition raw material has a predetermined shape and maintains a non-deformed state ,
As a result, the peeling protection member covers the surface and the edge of the raw material for the cutting/cooling non-deformable composition, and is in close contact with the peripheral margin of the holding member,
The packaging container deforms along the shape of the holding member / effective composition raw material/peeling protective member laminate due to the pressure difference between the inside and the outside of the packaging container, and is in a state of close contact. A package is obtained,
as well as,
(D) raising the temperature of the laminate-accommodating package to ripen the efficacy composition raw materials constituting the laminate-accommodating package into a flexible efficacy composition in a flexible state without fluidity; to the holding member to prepare a holding member/softening composition/release protection member laminate in which the softening composition is adhered and joined to the holding member, wherein the release protection member is The cross-linkable water-soluble polymer reacts with the cross-linking agent in a state where the surface and edges of the active composition raw material are covered and adhered to each other and the holding member is kept in close contact with the peripheral margin of the holding member. Crosslinked by reaction, the ingredients of the efficacy composition are matured into a water-containing gel-like softening efficacy composition having stickiness and flexibility without fluidity,
As a result, the peeling protection member covers the surface and edges of the softening composition and adheres thereto, and adheres to the margin around the holding member of the holding member,
The packaging container is in a state of being deformed and in close contact with the holding member/softening composition/peeling protective member laminate along the shape,
A patch comprising a holding member, a softening composition, and a peeling protective member is formed in which the softening composition does not protrude from the surface of the holding member and a margin around the holding member is formed, and the patch comprises: A patch containing packaged product in which the agent is contained in the packaging container is obtained.
A method for manufacturing an adhesive patch containing package, characterized by: The crosslinkable water-soluble polymer is at least polyacrylic acid, neutralized polyacrylic acid, partially neutralized polyacrylic acid, carboxyalkyl cellulose, acrylic acid-methacrylic acid copolymer, carboxyvinyl polymer, and these is at least one crosslinkable water-soluble polymer selected from the group consisting of salts of
In the step (D), the crosslinkable water-soluble polymer is crosslinked by a chemical reaction with the crosslinker, thereby forming a water-containing gel-like flexible composition in which the ingredients of the composition are in a flexible state without fluidity. A patch storage package is obtained in which a patch having a holding member, a flexible efficacy composition, and a peel protection member having a structure matured into a product is formed, and the patch is stored in the packaging container.
4. The method for manufacturing a patch containing package according to any one of claims 1 to 3, characterized in that: In the step (C), the reduced pressure state lower than atmospheric pressure is a reduced pressure state in the range of about 5 mmHg to about 700 mmHg.
5. The method for manufacturing a patch containing package according to any one of claims 1 to 4, characterized in that: The width dimension of the margin around the holding member is a distance and length dimension equal to or greater than the thickness dimension of the effective composition raw material.
6. The method of manufacturing a patch containing package according to any one of claims 1 to 5, characterized in that: A patch and a packaging container containing the patch,
The adhesive patch includes a sheet-like holding member, a flexible composition having flexibility and being laminated by adhering and bonding to a predetermined position area on the surface of the holding member, and the surface of the softening composition. and a sheet-like peeling protection member that is laminated so as to be peelable during use,
The softening composition has adhesiveness, and when used, the patch is taken out from the packaging container, and the peel protection member is peeled off from the taken out patch and laminated on the holding member. A patch storage package for use by attaching the bonded softening composition to the skin of a human body,
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening effect composition is prepared from a flowable effect composition raw material containing at least a crosslinkable water-soluble polymer that can be crosslinked with water and a cross-linking agent. It has the property of being chemically crosslinked into a three-dimensional structure and matured into a water-containing gel-like softening composition having stickiness and flexibility without fluidity,
The patch has a form in which it is placed in the packaging container , and is housed and sealed in the packaging container in a reduced pressure state lower than the atmospheric pressure in the packaging container. serve ,
(i) In the patch, the softening composition is positioned inside the periphery of the surface of the holding member to form a margin around the holding member, and the composition is applied to the surface of the holding member. and the peel protection member covers the softening composition and is formed in close contact with the margin around the holding member of the holding member,
The adhesive patch is positioned in the packaging container , the packaging container has a state of being in close contact with the adhesive along the shape of the adhesive patch, and the softening effect composition has adhesiveness and flexibility. having a matured form that
A patch storage package characterized by comprising: A patch and a packaging container containing the patch,
The adhesive patch includes a sheet-like holding member, a flexible composition having flexibility and being laminated by adhering and bonding to a predetermined position area on the surface of the holding member, and the surface of the softening composition. and a sheet-like peeling protection member that is laminated so as to be peelable during use,
The softening composition has adhesiveness, and when used, the patch is taken out from the packaging container, and the peel protection member is peeled off from the taken out patch and laminated on the holding member. A patch storage package for use by attaching the bonded softening composition to the skin of a human body,
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening effect composition is prepared from a flowable effect composition raw material containing at least a crosslinkable water-soluble polymer that can be crosslinked with water and a cross-linking agent. It has the property of being chemically crosslinked into a three-dimensional structure and matured into a water-containing gel-like softening composition having stickiness and flexibility without fluidity,
The patch has a form in which it is placed in the packaging container , and is housed and sealed in the packaging container in a reduced pressure state lower than the atmospheric pressure in the packaging container. serve ,
(ii) The patch is formed by laminating the softening composition on the surface of the holding member such that the softening composition is positioned on the surface region of the holding member without protruding from the surface of the holding member. and the peel protection member covers the surface of the softening composition and is formed in close contact with the end of the holding member and the end of the softening composition ,
The adhesive patch is positioned in the packaging container , the packaging container has a state of being in close contact with the adhesive along the shape of the adhesive patch, and the softening effect composition has adhesiveness and flexibility. having a matured form that
The softening composition between the holding member and the peeling protective member is prevented from protruding from between the holding member and the peeling protective member.
A patch storage package characterized by comprising: A patch and a packaging container containing the patch,
The adhesive patch includes a sheet-like holding member, a flexible composition having flexibility and being laminated by adhering and bonding to a predetermined position area on the surface of the holding member, and the surface of the softening composition. and a sheet-like peeling protection member that is laminated so as to be peelable during use,
The softening composition has adhesiveness, and when used, the patch is taken out from the packaging container, and the peel protection member is peeled off from the taken out patch and laminated on the holding member. A patch storage package for use by attaching the bonded softening composition to the skin of a human body,
The packaging container has flexibility to the extent that it can be deformed along the shape of the patch,
The softening effect composition is prepared from a flowable effect composition raw material containing at least a crosslinkable water-soluble polymer that can be crosslinked with water and a cross-linking agent. It has the property of being chemically crosslinked into a three-dimensional structure and matured into a water-containing gel-like softening composition having stickiness and flexibility without fluidity,
The patch has a form in which it is placed in the packaging container , and is housed and sealed in the packaging container in a reduced pressure state lower than the atmospheric pressure in the packaging container. serve ,
(i) In the patch, the softening composition is positioned inside the periphery of the surface of the holding member to form a margin around the holding member, and the composition is applied to the surface of the holding member. is laminated to
The peel protection member covers the surface and edges of the softening composition and is in close contact with the peripheral margin of the holding member,
The softening composition has a form in which it is laminated on the surface of the holding member with the margin around the holding member formed,
The adhesive patch is positioned in the packaging container , the packaging container has a state of being in close contact with the adhesive along the shape of the adhesive patch, and the softening effect composition has adhesiveness and flexibility. having a matured form that
The crosslinkable water-soluble polymer is at least polyacrylic acid, neutralized polyacrylic acid, partially neutralized polyacrylic acid, acrylic acid-methacrylic acid copolymer, carboxyalkyl cellulose, hydroxyalkyl cellulose, carboxyvinyl polymer. , and at least one crosslinkable water-soluble polymer selected from the group consisting of salts thereof,
A patch storage package characterized by comprising: The crosslinkable water-soluble polymer is at least polyacrylic acid, neutralized polyacrylic acid, partially neutralized polyacrylic acid, acrylic acid-methacrylic acid copolymer, carboxyalkyl cellulose, hydroxyalkyl cellulose, carboxyvinyl polymer. , and at least one crosslinkable water-soluble polymer selected from the group consisting of salts thereof,
The raw material for the efficacy composition further contains at least one selected from the group consisting of a percutaneously absorbable medicinal ingredient, a tackifier, and a skin absorption enhancer.
The adhesive patch storage package according to any one of claims 7 to 9, characterized in that:

Images