CN108553358A - A kind of whitening stains removing toothpaste and preparation method thereof - Google Patents
A kind of whitening stains removing toothpaste and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention relates to whitening stains removing dentifrice composition and its manufacturing methods, it is to provide the toothpaste containing stains removing whitening agent in more detail, utilize whitening agent ingredient, under rubbing agent synergistic effect, tooth-whitening, by controlling the addition step of each component and the technological parameter of each step in technical process, each component is pre-processed, it is pre-mixed rubbing agent, predissolve whitening agent and aromatic etc., pre-dispersed adhesive and moisturizer, in glue, mesh control during cream processed, homogeneous and de-airing step, obtain semi-finished product lotion, it is filling by the inspection of semifinished product, obtain whitening stains removing toothpaste.Whitening stains removing toothpaste of the present invention obtains the excellent properties of finished product by the parameter of the quality for controlling the raw materials such as purified water, the proportioning for controlling dispensing, control prefabrication step.
Description
Technical field
The present invention relates to whitening stains removing toothpaste and its manufacturing methods, are related in more detail by control production technology, rationally
The technological parameter for allocating preparation process, obtains with multi-efficiencies such as whitening, stains removing, preventing decayed tooths, the whitening for capableing of fresh breath is dispelled
Stain toothpaste.
Background technology
Generally, in order to which paste toothpaste is widely used in the toothpaste that is clean and using in oral cavity and tooth, but make for a long time
With or open pipe lid pass through certain time, then pipe fore-end solidification and be not easy squeeze out or non-serviceable situation compared with
It is more.In addition, in use, the toothpaste of pipe internal residual cannot be completely used up, the pipe of toothpaste is filled with as disposable
Pipe, can only throw away every time, so waste is serious, there are problems that causing environmental pollution.
The enamel of tooth is the most hard substance of human body.Its by about 98 parts hydroxyapatite (a kind of calcium phosphate
Crystal form) and some organic components composition.The thin layer of enamel is formed on tooth surfaces, and dentine is as substrate.Tooth enamel
Matter is more tough and tensile, and suitable for absorbing the stress of chewing without being broken.Dentine also includes hydroxyapatite, has higher hole
Gap rate and higher organic structure content.
External cause and internal cause can all cause tooth discoloration.For example, coffee, tea, wine, carrot, orange or tobacco can be in tooth enamels
Matter leaves spot on surface.Certain antibiotic, the intake of excessive fluoride or genetic disease can cause endogenous to change colour.Tooth
Tooth discoloration may be important aesthetic concerns for dental patients.
In general, surface blot can be removed by carrying out thoroughly cleaning to tooth by patient or healthy professional person.For
This is sometimes using the polishing agent (polishing) with abrasive materials, such as using including calcium phosphate, chalk, float stone or two
The paste of the particle of silica.If patient it is expected that further endogenous reduces tooth discoloration, chemical bleaching is classical
Option.
But in recent years, pair with bleach relevant side effect (such as the demineralization caused by peroxide, corrosion and tooth
Sensibility) cognition improved.It is destroyed it has been proposed that carrying out remineralization using hydroxide radical phosphorite nanocrystalline body and being for example bleached
Dental surface.Hydroxylapatite crystal particle (it is very similar to the natural material of tooth) can be deposited on tooth enamel
On.Cut or eroded section in addition to filling tooth, and prevent or treat saprodontia, the hydroxyapatite of deposition can also be fought
Dentinal tubule exposure caused tooth hypersensitivity when gingival atrophy.
Dental caries are a kind of chronic diseases that hard tooth tissue structure is gradually destroyed, and affect the life of people all the time
It is living, endanger the oral health of the mankind.The generation of saprodontia is since the demineralization of enamel, therefore the repairing research of demineralization enamel
It is of great significance for the prevention and treatment of saprodontia.Although present oral cavity material itself is lacked for repairing cavity or tooth
Damage is more effective, but is unable to reach the purpose for preventing saprodontia from occurring again.Ideal dental prosthetic material composition, structure and
Property etc. should be similar to dental tissue, so it is Dental Erosion to form similar hydroxyapatite material with enamel
Ideal material.
After enamel whole corrosion, the problems such as dentine will be exposed, cause hemodia, saprodontia.Therefore, in tooth sheet
Matter surface re-forms one layer of secured fine and close hydroxyapatite protective layer, it appears particularly important.
Invention content
Currently invention addresses solve above-mentioned conventional problems, and it is an object of the present invention to provide a kind of tooth with stains removing white-skinned face function
Cream, while also having the function of anti-caries.The present invention is provided the toothpaste containing stains removing whitening agent and is being rubbed using whitening agent ingredient
Under liniment synergistic effect, tooth-whitening, the technique by controlling the addition step and each step of each component in technical process is joined
Number, pre-processes each component, is pre-mixed rubbing agent, predissolve whitening agent and aromatic etc., pre-dispersed adhesive and moisturizing
Agent, mesh control, homogeneous and de-airing step during glue, cream processed obtain semi-finished product lotion, are filled by the inspection of semifinished product
Dress obtains whitening stains removing toothpaste.
The present inventor solves technical problem described above, specifically, the present invention provides a kind of whitening stains removing toothpaste,
It includes 40-60 parts of moisturizer, 10-20 parts of rubbing agent, 1-5 parts of foaming agent, 2-7 parts of caries preventive agent, 0.5-3 parts of virtues
Pastil, 0.2-2 parts of adhesive, 1-5 parts of stains removing whitening agent, 0.05-0.2 parts of sweetener, 0.02-0.5 parts of implication are clear
New agent and a small amount of preservative, surplus are purified water.
Preferred above-mentioned raw materials are that the moisturizer is selected from and is made of glycerine, propylene glycol, sorbierite and polyethylene glycol 400
Group, the rubbing agent includes hydrated silica, and the foaming agent includes K12, and the caries preventive agent includes hydroxyapatite, described to dispel
Stain whitening agent is selected from the group being made of sodium phytate and titanium dioxide, and the aromatic includes food flavor, and described adhesive is selected from
The group being made of xanthans and Chondrus crispus extract, the sweetener include tri-chloro galactose type sugar, and the flavorants are
Mint extract, the preservative are sodium benzoate.
It has surprisingly been found that in the dentifrice composition of the present invention, by rational proportion each component, control pretreatment and
Preparation process, obtained toothpaste has stains removing ability and whitening effect beyond imagination, good using sense organ.The toothpaste is main
Point or less three steps be prepared.
Step 1：Pre-process each component：
Accurate weighing each raw material component according to the ratio；
Purified water is added in predissolve pot, the water-soluble materials such as sodium phytate, sodium benzoate are added under moderate-speed mixer, stirring is molten
Solution is uniform, forms aqueous solution (1)；
The pulvis such as rubbing agent, whitening agent, caries preventive agent are added in premixing pot, moderate-speed mixer is uniform, forms pulvis (2)；
Part moisturizer is added in pre-dispersed pot, adhesive is added under moderate-speed mixer, is dispersed with stirring uniformly, slurry is made
(3)；
Step 2：Charging：
Scraper plate moderate-speed mixer is opened when vacuum Manufacturing medicine extract machine is run, then the sorbitol aqueous solution after metering is added in pump carries
High mixing speed is uniformly mixed；
It vacuumizes, maintains negative pressure in about -0.03MPa, the above-mentioned aqueous solution of inspiration (1), moderate-speed mixer is uniform；
Above-mentioned vacuum condition is maintained, opens homogenizer, inspiration slurry (3), moderate-speed mixer is uniform；
Above-mentioned vacuum condition is maintained, the above-mentioned pulvis of inspiration (2), moderate-speed mixer is uniform；
While vacuum degree is improved to -0.09MPa, foaming agent, moderate-speed mixer to homogeneous is added, process continues 10-
15min；
Maintain above-mentioned vacuum condition, inspiration aromatic, moderate-speed mixer to homogeneous, mixing time continues 5-10min；
Step 3：Degassing, homogeneous and filling：
Vacuum degree is improved to -0.094MPa, moderate-speed mixer deaerates, and process continues 10-15min；
Homogenizer, blender and scraper plate are closed in order, restore pressure to normal pressure；
It is filling after the sampled detection of lotion, obtain a kind of whitening stains removing toothpaste.
It is measured with preparing one ton of lotion, predissolve time preferably 1-10min, preferably 2-4min in step 1, pre- point
Dissipate preferably 1-5min, preferably 1-3min.Feed time is preferably 3-20min in step 2, preferably 5-10min.Step
Cream time processed is preferably 15-20min in three.
The whitening stains removing toothpaste of the present invention prepares purified water using purified water machine, examines a water quality, Water-quality control weekly
In conductivity≤15us/cm, total plate count≤80/g.
The whitening stains removing toothpaste of the present invention does not add the material for not meeting food safety requirements.
Specific implementation mode
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, the embodiment
It is only used for explaining the present invention, be not intended to limit the scope of the present invention..It should be understood that one or more that the present invention mentions
A step does not repel before and after the combination step that there is also between other method and steps or these specifically mentioned steps
Other method and steps can also be inserted into.It should also be understood that these examples are merely to illustrate the present invention rather than the limitation present invention
Range.Unless otherwise indicated, the number of various method steps is only the purpose of discriminating various method steps, rather than is each side of limitation
The ordering of method or the practical range for limiting the present invention, relativeness are altered or modified, and become in no substantial technological content
Under conditions of more, when being also considered as the enforceable scope of the present invention.
The present invention provides a kind of whitening stains removing toothpaste, and preferred group becomes：Including 40-60 parts of moisturizer, 10-20 parts
Rubbing agent, 1-5 parts of foaming agent, 2-7 parts of caries preventive agent, 0.5-3 parts of aromatic, 0.2-2 parts of adhesive, 1-5 parts dispel
Stain whitening agent, 0.05-0.2 parts of sweetener, 0.02-0.5 parts of flavorants and a small amount of preservative, surplus are purifying
Water.
Preferred moisturizer is selected from the group being made of glycerine, propylene glycol, sorbierite and polyethylene glycol 400, preferred to rub
Agent includes hydrated silica, and preferred foaming agent includes K12, and preferred caries preventive agent includes hydroxyapatite, preferred stains removing whitening
Agent is selected from the group that is made of sodium phytate and titanium dioxide, and preferred aromatic includes food flavor, preferred adhesive be selected from by
The group of xanthans and Chondrus crispus extract composition, preferred sweetener include tri-chloro galactose type sugar, preferred flavorants
For mint extract, preferred preservative is sodium benzoate.
It is preferred that the dentifrice composition of the present invention is prepared by following steps：
Step 1：Pre-process each component：
Accurate weighing each raw material component according to the ratio；
Purified water is added in predissolve pot, the water-soluble materials such as sodium phytate, sodium benzoate are added under moderate-speed mixer, stirring is molten
Solution is uniform, forms aqueous solution (1)；
The pulvis such as rubbing agent, whitening agent, caries preventive agent are added in premixing pot, moderate-speed mixer is uniform, forms pulvis (2)；
Part moisturizer is added in pre-dispersed pot, adhesive is added under moderate-speed mixer, is dispersed with stirring uniformly, slurry is made
(3)；
Step 2：Charging：
Scraper plate moderate-speed mixer is opened when vacuum Manufacturing medicine extract machine is run, then the sorbitol aqueous solution after metering is added in pump carries
High mixing speed is uniformly mixed；
It vacuumizes, maintains negative pressure in about -0.03MPa, the above-mentioned aqueous solution of inspiration (1), moderate-speed mixer is uniform；
Above-mentioned vacuum condition is maintained, opens homogenizer, inspiration slurry (3), moderate-speed mixer is uniform；
Above-mentioned vacuum condition is maintained, the above-mentioned pulvis of inspiration (2), moderate-speed mixer is uniform；
While vacuum degree is improved to -0.09MPa, foaming agent, moderate-speed mixer to homogeneous is added, process continues 10-
15min；
Maintain above-mentioned vacuum condition, inspiration aromatic, moderate-speed mixer to homogeneous, mixing time continues 5-10min；
Step 3：Degassing, homogeneous and filling：
Vacuum degree is improved to -0.094MPa, moderate-speed mixer deaerates, and process continues 10-15min；
Homogenizer, blender and scraper plate are closed in order, restore pressure to normal pressure；
It is filling after the sampled detection of lotion, obtain a kind of whitening stains removing toothpaste.
Embodiment 1
Each raw material, purified water processed are configured according to the following ratio：
45 parts of sorbierite, polyethylene glycol 400 account for 5 parts, and 3 parts of glycerine, 18 parts of hydrated silica, K12 accounts for 2.5 parts, hydroxy-apatite
5 parts of stone, 2 parts of sodium phytate, 1.2 parts of food flavor, 0.5 part of xanthans, 0.3 part of Chondrus crispus extract, zinc citrate 0.3
Part, titanium dioxide 0.15,0.1 part of tri-chloro galactose type sugar, 0.2 part of mint extract, 0.2 part of sodium benzoate, surplus is purified water.With
1T is counted, and each component weight is accurate to 0.1g.
The purified water is crossed purifying water dispenser via deionized water and is obtained, and the operation principle of the ultrapure water machine is：Pass through two
Ion and organic matter in grade purification column (containing ion exchange resin and activated carbon) removal pure water, then pass through 185nm, 254nm
The further organics removal of double-wavelength ultraviolet lamp photooxidation most obtains the super of high-quality through 0.22 μm of micro-pore-film filtration afterwards
Pure water.
Embodiment 2
Pre-process each raw material component
It is premixed in stainless steel and adds appropriate purified water in pot, tri-chloro galactose type sugar and zinc citrate, benzene is added under moderate-speed mixer
Sodium formate, sodium phytate, mint extract, stirring and dissolving is uniform, predissolve time 4min, and aqueous solution (1) is made.
In premixing pot hydrated silica, hydroxyapatite and titanium dioxide, moderate-speed mixer 3min is uniformly mixed, and powder is made
Agent (2).
Glycerine is added in pre-dispersed pot, xanthans and Chondrus crispus extract are added under moderate-speed mixer, it is pre-dispersed
Slurry (3) is made in time 3min.
Embodiment 3
Charging is produced and is examined filling
Vacuum Manufacturing medicine extract machine is run, scraper plate stirring is opened, sorbierite, polyethylene glycol 400 and excess water is squeezed into after metering
Manufacturing medicine extract machine is uniformly mixed above-mentioned raw materials under high velocity agitation.It vacuumizes, under the conditions of negative pressure -0.03MPa, sucking first is implemented
The aqueous solution (1) that example 2 is prepared, is uniformly mixed with stoste under high velocity agitation.Condition of negative pressure is maintained, equalizer is opened, is inhaled
The slurry (3) being prepared into embodiment 2, high-speed stirred is uniform.Maintain condition of negative pressure, the powder that inspiration embodiment 2 is prepared
Agent (2), stirs evenly.Foaming agent K12 is sucked equally under condition of negative pressure, and vacuum degree is during which increased to -0.09MPa, vacuum
While degassing, carries out homogeneous and stir 15min.It is equal that vacuum degree extremely -0.03MPa, inspiration food flavor, moderate-speed mixer are reduced afterwards
It is even, continue to stir 10min, completes charging.
After completing charging, vacuum degree is improved to -0.094MPa, continues homogeneous and vacuum outgas, time 15min is complete
Cheng Houguan equalizers, blender and scraper plate release vacuum condition, lotion of toothpaste 1 are made, and take cream body is tested, and are filled after qualified
Fill hose.
Comparative example 1
Using composition same as Example 1, difference is to substitute purified water with deionized water, is taken and embodiment 2 and 3 phases
Lotion 2 is made in same step.
Comparative example 2
Using composition same as Example 1, difference is to have adjusted production craft step, and lotion is obtained after completing charging
3。
Experimental example 1
Below to test antibacterial ability of the lotion to the organism of oral cavity harmful bacteria, the test strain used at this time is applicable in
Tooth is set to send out Streptococcus mutans (Streptococcus mutans cariogenic；NCTC 10449).
Above-mentioned test strain is taken out from freezing keeping state, after being inoculated in nutrient broth (Nutrient broth),
It is cultivated 48 hours in 37 DEG C of culture medium, each test bacteria liquid of such preculture is inoculated in the battalion of 100ml with 1% (v/v)
After supporting meat soup, after cultivating 12-20 hours again in the medium, for testing.
In order to test, the initial value of bacterial population (bacterial suspension number) appropriate is 106~
107cell/ml, for this purpose, respectively take 1ml to be respectively put into the sterile purified water of the 100ml sterilized in advance from the bacterium solution of preculture,
Using this as stoste, after gradually dilution method is diluted, it will respectively be coated on solid medium, it is small to be cultivated 24
When, regenerated colony is counted, initial vaccination concentration is found out.
On the other hand, the preparation of experimental liquid is that the composition prepared as lotion 1-3 is mixed in sterilizing in the same amount
In distilled water, through a long time dissolves to prepare.
Also, it respectively takes 1ml to pour into respectively each experimental liquid of above-mentioned preparation and has adjusted the test strain of initial vaccination concentration
In, after 1 minute time, measure remaining bacterium number.The measurement of bacterium number carries out by the following method, that is, by the stoste of recycling
It is diluted by gradually dilution method, is coated on tablet training base according to each extension rate, it, will after being cultivated in culture machine
The bacterium colony of each tablet training base is counted, whether determining the reduction according to the bacterium number of remaining bacterium number, to measure antibacterial ability.It is logical
Such method is crossed using the concentration of the remaining bacterium number to initial vaccination concentration, bacteriostasis rate (%) is found out with percentage, with the suppression
Bacterium rate (%) arranges antibacterial ability (sterilizing ability), then as described in Table 1.
Table 1
| Test strain | Lotion 1 | Lotion 2 | Lotion 3 |
| Streptococcus mutans | 99% | 85% | 90% |
As shown in table 1, by experimental example 1：The lotion 2 that unused purified water is prepared, for tested bacterial strain
Sterilizing ability it is significantly low, the sterilizing ability for not carrying out the lotion 3 of homogeneous and emptying fully is also insufficient.
Experimental example 2
Experimental example 2 below be to the composition according to the lotion 1-3 of above-mentioned manufacture, it is entitled with the men and women that grows up each 10 respectively
Object is used, and is examined according to 5 point scale methods to removing halitosis, removing plaque, use feeling implementation sense organ, bubble value, will
Its average value is shown in following table 2.
Table 2
| Inspection item | Lotion 1 | Lotion 2 | Lotion 3 |
| Remove halitosis | 4.6 | 3.0 | 4.0 |
| Remove dental plaque | 4.5 | 3.0 | 3.8 |
| Use feeling | 4.7 | 4.5 | 2.6 |
| Bubble rate | 4.8 | 4.5 | 2.5 |
| It is average | 4.65 | 3.75 | 3.225 |
＜ very 5,4, general 3, poor 2, excessively poor 1 ＞
As shown in table 2, by above-mentioned experimental example 2：Homogeneous and paste manufacture process use sense organ and antibacterial to toothpaste
Property has an impact, and is affected to the antibiotic property of toothpaste using non-purified water.
By above description illustrate dentifrice composition according to the preferred embodiment of the present invention as described above and its
Manufacturing method, but this is merely illustrative of, and those skilled in the art should be able to be best understood by the skill for not departing from the present invention
Various change and change can be carried out in the range of art thought.
Claims (7)
1. a kind of whitening stains removing dentifrice composition, which is characterized in that including 40-60 parts of moisturizer, 10-20 parts of rubbing agent,
1-5 parts of foaming agent, 2-7 parts of caries preventive agent, 0.5-3 parts of aromatic, 0.2-2 parts of adhesive, 1-5 parts of stains removing whitening
Agent, 0.05-0.2 parts of sweetener, 0.02-0.5 parts of flavorants and a small amount of preservative, surplus are purified water.
2. whitening stains removing dentifrice composition according to claim 1, which is characterized in that form whitening by the following method and dispel
Stain dentifrice composition：
Step 1：Pre-process each component：
Accurate weighing each raw material component according to the ratio；
Purified water is added in predissolve pot, it is equal that water-soluble materials, the stirring and dissolvings such as sodium phytate, sodium benzoate is added under moderate-speed mixer
It is even, form aqueous solution (1)；
The pulvis such as rubbing agent, whitening agent, caries preventive agent are added in premixing pot, moderate-speed mixer is uniform, forms pulvis (2)；
Part moisturizer is added in pre-dispersed pot, adhesive is added under moderate-speed mixer, is dispersed with stirring uniformly, slurry (3) is made；
Step 2：Charging：
Scraper plate moderate-speed mixer is opened when vacuum Manufacturing medicine extract machine is run, then the sorbitol aqueous solution after metering is added in pump is improved and stirred
Speed is mixed, is uniformly mixed；
It vacuumizes, maintains negative pressure in about -0.03MPa, the above-mentioned aqueous solution of inspiration (1), moderate-speed mixer is uniform；
Above-mentioned vacuum condition is maintained, opens homogenizer, inspiration slurry (3), moderate-speed mixer is uniform；
Above-mentioned vacuum condition is maintained, the above-mentioned pulvis of inspiration (2), moderate-speed mixer is uniform；
While vacuum degree is improved to -0.09MPa, foaming agent, moderate-speed mixer to homogeneous is added, process continues 10-15min；
Maintain above-mentioned vacuum condition, inspiration aromatic, moderate-speed mixer to homogeneous, mixing time continues 5-10min；
Step 3：Degassing, homogeneous and filling：
Vacuum degree is improved to -0.094MPa, moderate-speed mixer deaerates, and process continues 10-15min；
Homogenizer, blender and scraper plate are closed in order, restore pressure to normal pressure；
It is filling after the sampled detection of lotion, obtain a kind of whitening stains removing toothpaste.
3. whitening stains removing toothpaste according to claim 1, which is characterized in that the moisturizer be selected from by glycerine, propylene glycol,
The group of sorbierite and polyethylene glycol 400 composition, the rubbing agent includes hydrated silica, and the foaming agent includes K12, the preventing decayed tooth
Agent includes hydroxyapatite, and the stains removing whitening agent is selected from the group being made of sodium phytate and titanium dioxide, and the aromatic includes
Food flavor, described adhesive are selected from the group being made of xanthans and Chondrus crispus extract, and the sweetener includes trichlorine
Galactolipin, the flavorants are mint extract, and the preservative is sodium benzoate.
4. whitening stains removing toothpaste according to claim 1, which is characterized in that the purified water is prepared by purified water machine
It arrives, conductivity≤15us/cm of purified water, total plate count≤80/g.
5. whitening stains removing toothpaste according to claim 1, which is characterized in that each component precise in proportion, production
1T lotions, each raw material are accurate to 0.1g.
6. whitening stains removing toothpaste according to claim 1, which is characterized in that, filling environment filling by flexible tube filling machine
For：Through ultraviolet sterilization 30min, the sterilized dedusting of operator before filling.
7. a kind of preparation method of whitening stains removing toothpaste, the toothpaste include 40-60 parts of moisturizer, 10-20 parts of rubbing agent,
1-5 parts of foaming agent, 2-7 parts of caries preventive agent, 0.5-3 parts of aromatic, 0.2-2 parts of adhesive, 1-5 parts of stains removing whitening
Agent, 0.05-0.2 parts of sweetener, 0.02-0.5 parts of flavorants and a small amount of preservative, surplus is purified water, described
Moisturizer is selected from the group being made of glycerine, propylene glycol, sorbierite and polyethylene glycol 400, and the rubbing agent includes hydrated silica, institute
It includes K12 to state foaming agent, and the caries preventive agent includes hydroxyapatite, and the stains removing whitening agent is selected from by sodium phytate and titanium dioxide
The group of composition, the aromatic include food flavor, and described adhesive is selected from and is made of xanthans and Chondrus crispus extract
Group, the sweetener include tri-chloro galactose type sugar, the flavorants be mint extract, the preservative be benzoic acid
Sodium, which is characterized in that
Whitening stains removing dentifrice composition is formed by the following method：
Step 1：Pre-process each component：
Accurate weighing each raw material component according to the ratio；
Purified water is added in predissolve pot, it is equal that water-soluble materials, the stirring and dissolvings such as sodium phytate, sodium benzoate is added under moderate-speed mixer
It is even, form aqueous solution (1)；
The pulvis such as rubbing agent, whitening agent, caries preventive agent are added in premixing pot, moderate-speed mixer is uniform, forms pulvis (2)；
Part moisturizer is added in pre-dispersed pot, adhesive is added under moderate-speed mixer, is dispersed with stirring uniformly, slurry (3) is made；
Step 2：Charging：
Scraper plate moderate-speed mixer is opened when vacuum Manufacturing medicine extract machine is run, then the sorbitol aqueous solution after metering is added in pump is improved and stirred
Speed is mixed, is uniformly mixed；
It vacuumizes, maintains negative pressure in about -0.03MPa, the above-mentioned aqueous solution of inspiration (1), moderate-speed mixer is uniform；
Above-mentioned vacuum condition is maintained, opens homogenizer, inspiration slurry (3), moderate-speed mixer is uniform；
Above-mentioned vacuum condition is maintained, the above-mentioned pulvis of inspiration (2), moderate-speed mixer is uniform；
While vacuum degree is improved to -0.09MPa, foaming agent, moderate-speed mixer to homogeneous is added, process continues 10-15min；
Maintain above-mentioned vacuum condition, inspiration aromatic, moderate-speed mixer to homogeneous, mixing time continues 5-10min；
Step 3：Degassing, homogeneous and filling：
Vacuum degree is improved to -0.094MPa, moderate-speed mixer deaerates, and process continues 10-15min；
Homogenizer, blender and scraper plate are closed in order, restore pressure to normal pressure；
It is filling after the sampled detection of lotion, obtain a kind of whitening stains removing toothpaste.
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| CN110801404A (en) * | 2019-11-19 | 2020-02-18 | 庐山百草堂生物制药有限公司 | Dihydromyricetin-containing tooth whitening and repairing toothpaste and preparation method thereof |
| CN110897922A (en) * | 2020-01-02 | 2020-03-24 | 广东立爽生物科技有限公司 | Stain-removing whitening toothpaste and preparation method thereof |
| CN112120987A (en) * | 2020-11-01 | 2020-12-25 | 贵州锦黔商贸有限公司 | Roxburgh rose VC toothpaste and preparation method thereof |
| CN112773727A (en) * | 2020-11-10 | 2021-05-11 | 江苏雪豹日化有限公司 | Preparation method of stain-removing and whitening biological lysozyme toothpaste composition |
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| CN110801404A (en) * | 2019-11-19 | 2020-02-18 | 庐山百草堂生物制药有限公司 | Dihydromyricetin-containing tooth whitening and repairing toothpaste and preparation method thereof |
| CN110897922A (en) * | 2020-01-02 | 2020-03-24 | 广东立爽生物科技有限公司 | Stain-removing whitening toothpaste and preparation method thereof |
| CN112120987A (en) * | 2020-11-01 | 2020-12-25 | 贵州锦黔商贸有限公司 | Roxburgh rose VC toothpaste and preparation method thereof |
| CN112773727A (en) * | 2020-11-10 | 2021-05-11 | 江苏雪豹日化有限公司 | Preparation method of stain-removing and whitening biological lysozyme toothpaste composition |
| CN112773727B (en) * | 2020-11-10 | 2023-08-11 | 江苏雪豹日化有限公司 | Preparation method of stain-removing whitening biological lysozyme toothpaste composition |
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