CN107982185A - A kind of toothpaste with low abrasion and high cleaning benefits - Google Patents
A kind of toothpaste with low abrasion and high cleaning benefits Download PDFInfo
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- CN107982185A CN107982185A CN201711120554.5A CN201711120554A CN107982185A CN 107982185 A CN107982185 A CN 107982185A CN 201711120554 A CN201711120554 A CN 201711120554A CN 107982185 A CN107982185 A CN 107982185A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention discloses a kind of toothpaste with low abrasion and high cleaning benefits.By weight percentage, the toothpaste includes 20~40% abrasive composition, moisturizer, thickener, surfactant, sweetener, preservative, essence, deionized water etc..The abrasive composition includes 5~20% cuttlebone and 10~30% sodium bicarbonate (sodium acid carbonate).It is of the invention that the obtained natural abrasive of albumen processing is first taken off to cuttlebone progress degreasing, then be added to sodium bicarbonate (sodium acid carbonate) composition abrasive composition in toothpaste, so as to provide a kind of with low abrasion, the toothpaste of noble and unsullied flute profile.
Description
Technical field
The present invention relates to a kind of abrasive composition toothpaste, more particularly to a kind of low abrasion, noble and unsullied flute profile abrasive to combine
Thing toothpaste, belongs to oral cavity cleaning and nursing technical field.
Background technology
Toothpaste is mixed by the paste that abrasive, moisturizer, thickener, surfactant, essence, sweetener, water etc. form
Compound.Conventional abrasive mainly has calcium carbonate (calcite in powder/powdered whiting), dicalcium phosphate dihydrate, anhydrous phosphorus at present
Sour hydrogen calcium, aluminium hydroxide, silica etc..Calcium carbonate (calcite in powder/powdered whiting), calcium phosphate dibasic anhydrous, aluminium hydroxide
Contour friction value abrasive material can more or less cause enamel certain abrasion, dicalcium phosphate dihydrate, silica etc. soft
Property abrasive material, though will not cause to wear to tooth, is disadvantageous in that cleaning force is inadequate, undesirable to tooth whitening effect.
Cuttlebone abundance, it is cheap, there is three-dimensional netted, porous room rack and panel construction, main component is calcium carbonate
(aragonitic is crystalline), good biocompatibility, being added in toothpaste has attrition value with skeleton and tooth composition relatively
Low, the characteristics of cleaning benefits are good, while also there is " natural " concept.
Sodium bicarbonate (sodium acid carbonate) is used as a kind of water-soluble abrasive, has the advantages that safe, strong cleaning force, more next
More paid attention to be subject to oral cavity cleaning and nursing industry.Sodium bicarbonate (sodium acid carbonate) itself is unstable, is combined with water and releases carbon dioxide,
It is added in toothpaste and easily causes inflatable or separation water outlet phenomenon, this just constrains sodium bicarbonate (sodium acid carbonate) as abrasive in tooth
Application in cream.
The United States Patent (USP) US 4623536 and US4721614 of Winston et al. is directed to one kind and contains at least 60% carbonic acid
The toothpaste of hydrogen sodium, sodium bicarbonate (sodium acid carbonate) the toothpaste entrance of this high-content is just very salty and bitter, and consumer can be caused to be difficult to receive,
Sodium bicarbonate (sodium acid carbonate) content is higher, and stability is poorer, and lotion is more coarse, and foam sense is poorer, the sense organ of entire effect toothpaste
And performance.
The United States Patent (USP) US5180576 and US5318773 of Winston et al. further relates to a kind of by pyrophosphate and bicarbonate
Sodium is mixed into toothpaste, and Chinese patent CN1168093A is related to the pyrophosphoric acid four comprising 5~50% sodium acid carbonate and at least 1.5%
Sodium.Though pyrophosphate can stablize the pH of baking soda dentifrice, lotion discoloration can be aggravated, excessive pyrophosphate can also cause lotion
Denseness excessively increases, and causes lotion to harden and loses moist, influences toothpaste appearance.
The content of the invention
In view of the above-mentioned problems, the object of the present invention is to provide a kind of toothpaste with low abrasion and high cleaning benefits, avoid
The problem of abrasion of the high friction value toothpaste of tradition to enamel, low friction value toothpaste cleaning force are bad.
The purpose of the present invention is what is realized by following technical solution.
A kind of toothpaste with low abrasion and high cleaning benefits, by weight percentage, includes 20~40% abrasive
Composition, moisturizer, thickener, surfactant, sweetener, preservative, essence, deionized water etc..
A kind of toothpaste with low abrasion and high cleaning benefits, by weight percentage, the abrasive composition includes 5
~20% cuttlebone, 10~30% sodium bicarbonate (sodium acid carbonate).
A kind of toothpaste with low abrasion and high cleaning benefits, by weight percentage, also comprising 40~60% moisturizing
Agent, 1.0~1.2% thickener, 2~3% surfactant, 0.15~0.3% sweetener, 0.15~0.3% it is anti-
Rotten agent, 1.0~1.5% essence, deionized water are added to 100%.
The natural abrasive is that cuttlebone degreasing is taken off albumen processing, is made and is suitable for adding the friction in toothpaste
Agent.
The cuttlebone degreasing of the present invention takes off albumen treatment process and is：
Take fresh cuttlebone, retain inner core except decapsidate after dry, it is powdered to be ground into 100~150 mesh, adds 4~5 times
2%~4% NaOH aqueous solutions of amount, capping are cooked by slow fire 20~30 minutes after boiling, are cooled to room temperature, by filemot boiling
Liquid filters off, and cuttlebone powder is rinsed with a large amount of clear water, untill water lotion is constant in water white transparency, continuous 3 water lotion pH, then
By dehydration, (105 DEG C) dryings of high temperature, grind, and the natural abrasive of cuttlebone of 200~300 mesh is made.
Through lye boiling and washing process, fat, most of protein and the other organic impurities in cuttlebone are eliminated,
Cuttlebone after processing has the advantages that no fishy smell, whiteness height, good hydrophilic property, is more suitable for the natural abrasive for making toothpaste.
The sodium bicarbonate (sodium acid carbonate) is ultra tiny particle diameter, makes the finer and smoother light of toothpaste, fineness control 800~
1000 mesh.
The moisturizer is glycerine, one or more mixtures in sorbierite, polyethylene glycol, propane diols.
The thickener is sodium carboxymethylcellulose, one or more mixtures in xanthans, melon glue.
The surfactant is laruyl alcohol sodium sulfovinate, in sodium lauroyl sarcosine, Cocoamidopropyl betaine
One or more mixtures.
The sweetener is saccharin sodium, one or more mixtures in acesulfame potassium, button sweet tea.
The preservative is one or both of sodium benzoate, parabens mixture.
Further, in order to mitigate the discoloration problem of sodium bicarbonate (sodium acid carbonate) toothpaste, a small amount of zinc citrate is also added, its
Additive amount should ensure that lotion pH more than 8.3.
Further, appearance modifying agents, such as titanium dioxide, pigment can also be added.
Further, suitable silica or other conventional abrasives can also be added.
The cuttlebone that degreasing takes off after albumen processing is added in toothpaste, has the following advantages that：
1st, for cuttlebone as a kind of marine organisms bone, internal organic matter may have certain immunogenicity, and
The microorganisms such as bacterium, virus, after degreasing takes off albumen processing and high temperature drying, internal immunogenicity and microorganism are killed,
Improve application security of the cuttlebone in toothpaste.
2nd, after degreasing takes off albumen processing, fishy smell is removed cuttlebone, the fishy smell of cuttlebone to toothpaste mouthfeel and
Fragrance has a great influence.Experiment proves：Conventional drying sterilizes the fishy smell that cannot remove cuttlebone, though microwave charing or high temperature carbonization energy
Fishy smell is removed, but cuttlebone is changed into black after organic matter carbonizing, the addition of black cuttlebone is difficult to allow consumer to connect in toothpaste
By, and organic carbon still has harmful effect to mouthfeel.
3rd, cuttlebone hydrophily itself is poor, and after degreasing takes off albumen processing, top layer is no longer containing the organic matters such as fat, tool
There is more preferable hydrophily, add the affinity and friction of cuttlebone and enamel, enhance whitening effect.
4th, cuttlebone has bigger, more open three-dimensional netted and porous room posture knot after degreasing takes off albumen processing
Structure, the harmful bacteria be conducive in oral cavity enter in cuttlebone micropore, reduce the harmful bacteria in oral cavity；It is also beneficial to adsorption orifice
Cause odour in chamber, quickly removes oral peculiar smell, substantially increases the bioactivity and bioavilability of cuttlebone.
5th, for cuttlebone after degreasing takes off albumen processing, appearance is relatively white, meets the appearance requirement of toothpaste abrasive.
If taking off albumen processing without degreasing, these nutrient rich are easy to cooperating microorganisms, influence product quality.In order to verify place
Effect to be managed, the cuttlebone handled well is reprocessed again, water cooking liquid is water white transparency, illustrates this method processing ratio more thoroughly, and
Other processing methods are substantially better than, there is simple and practicable, significant effect, pollution-free noresidue.
Toothpaste of the present invention has the following advantages that and beneficial effect：
1st, the present invention has the toothpaste of low abrasion and high cleaning benefits, using cuttlebone as mechanical friction agent, with sodium bicarbonate (carbon
Sour hydrogen sodium) for water-soluble abrasive, both combine, can provide it is a kind of there is low abrasion, the toothpaste of noble and unsullied flute profile, avoid tradition
The problem of abrasion of the high friction value toothpaste to enamel, low friction value toothpaste cleaning force are bad.Although cuttlebone main component is
Calcium carbonate, but, natural whiting ultra microstructure surface different with natural whiting (calcite in powder/powdered whiting) space structure
There is acute angle more, tooth glaze paint can be caused to wear, for three-dimensional netted and porous room rack and panel construction, the power that cleans the teeth is good not to grind cuttlebone again
Damage enamel.
2nd, a kind of abrasive composition toothpaste of the invention, cuttlebone can also stablize sodium bicarbonate (carbon in addition to as abrasive
Sour hydrogen sodium), stablize the toothpaste softness heavily fortified point that sodium bicarbonate (sodium acid carbonate) is more advantageous, makes than traditional phosphate, pyrophosphate
Very, it is normal to squeeze cream pressure.Increase larger after sodium bicarbonate (sodium acid carbonate) toothpaste denseness that pyrophosphate is stablized, easily make lotion pressure
Increase, even harden and lose moist, is unfavorable for the use of consumer.Phosphate, pyrophosphate are alkaline larger in itself, are more easy to make
Sodium bicarbonate (sodium acid carbonate) toothpaste changes colour, and cuttlebone main component is calcium carbonate, and alkalescent, is not easy to make sodium bicarbonate (sodium acid carbonate)
Toothpaste changes colour, so cuttlebone stablizes sodium bicarbonate (sodium acid carbonate) and has more superiority than traditional phosphate, pyrophosphate.
3rd, cuttlebone of the invention is after degreasing takes off albumen processing, specific surface area bigger, it is more open three-dimensional netted and
Porous room rack and panel construction, makes it have excellent absorption property, during brushing teeth can with the tooth stain of dental surface, bacterial plaque,
Tartar quickly combines, and reaches stain whitening effect.Sodium bicarbonate (sodium acid carbonate) has excellent cleaning force, can be fast instant when brushing teeth
Solve and go deep into teeth space, remove the spot and saliva glycoprotein film of dental surface.Both cuttlebone and sodium bicarbonate (sodium acid carbonate) group
Conjunction has synergistic function, whitening and Anti-dental injury enamel.Traditional whitening agent (such as sodium phytate, pyrophosphate, tripolyphosphate)
Although can reach tooth-whitening by complexing, long-time service can make enamel decalcification, cause tooth to feel like jelly powerless.
4th, cuttlebone of the invention is after degreasing takes off albumen processing, the specific surface area of bigger be conducive to adsorption of hydrogen sulfide,
Methyl mercaptan etc. causes odour, quickly eliminates oral peculiar smell；Sodium bicarbonate (sodium acid carbonate) is equally excellent eliminating smell agent, small when brushing teeth
The carbon dioxide of soda (sodium acid carbonate) release has very strong impact force, is conducive to the outburst of fragrance, so as to increase whole mouth
The comfort of chamber, makes implication extraordinarily pure and fresh.
5th, a kind of abrasive composition toothpaste of the invention, cuttlebone therein is similar to hard tooth tissue component, to tooth
Enamel has good affinity, biocompatibility and bioactivity, and particularly after degreasing takes off albumen processing, hydrophily is more
It is good, the affinity and friction to enamel are added, during daily brush teeth, can constantly be pierced from biophysical effect
Swash and activate tissue of tooth, the enamel of repair deficiency.
6th, current silica toothpaste is popular, and this toothpaste is in mostly faintly acid or neutrality, is unfavorable for tooth ore deposit again
Change (tooth easy demineralization in faintly acid or neutral environment).A kind of abrasive composition toothpaste of the present invention, lotion pH controls exist
More than 8.3, belong to alkalescent toothpaste.When in use, a large amount of ultra tiny sodium bicarbonate (sodium acid carbonate) and saliva contacts are molten for the toothpaste
Xie Hou, pH increase rapidly to more than 9.0, can deep layer cleaning slot, the formation of effective pre- dental calculus preventing, lifts tooth finish,
And tooth demineralization will not be caused.Acive calcium ion, the phosphate anion of cuttlebone offer also help remineralization of teeth, protect tooth
Tooth health.
7th, a kind of abrasive composition toothpaste of the invention, sodium bicarbonate (sodium acid carbonate) additive amount are controlled within 30%,
The sodium bicarbonate (sodium acid carbonate) of high-content is avoided to easily cause toothpaste stability is poor, foam sense is poor, appearance is coarse and mouthfeel is salty and bitter etc.
Bad phenomenon.The present invention mitigates sodium bicarbonate (sodium acid carbonate) discoloration problem, and cuttlebone by adding suitable zinc citrate
Stablize the pH of sodium bicarbonate (sodium acid carbonate) toothpaste together, develop the toothpaste with good appearance and stable quality.
8th, the cuttlebone and sodium bicarbonate (sodium acid carbonate) after degreasing is taken off albumen processing by the present invention first are as abrasive group
Compound is applied in toothpaste, and a kind of low abrasion, noble and unsullied flute profile tooth are provided for the consumer of enamel depauperation or tooth wear
Cream, has filled up existing market blank, will have good market prospects.
Embodiment
The present invention has the toothpaste of low abrasion and high cleaning benefits, by the gross weight meter of dentifrice composition, comprising 20~
40% abrasive composition, 40~60% moisturizer, 1.0~1.2% thickener, 2~3% surfactant,
0.15~0.3% sweetener, 0.15~0.3% preservative, 1.0~1.5% essence and deionized water surplus add to
100%.
The abrasive composition by weight percentage, comprising 5~20% degreasing take off albumen processing cuttlebone, 10
~30% sodium bicarbonate (sodium acid carbonate).Two kinds of abrasive combinations can be mutually synergistic, on the one hand can stablize little Su very well
(sodium acid carbonate) toothpaste is played, on the other hand a kind of low mill can be provided for the consumer of enamel hypoplasia or tooth wear
Damage, high cleaning toothpaste.
It is that the brief of abrasive composition raw material monomer of the present invention is introduced below：
Cuttlebone, also known as cuttle bone, are the inner casing of Sepiidae animal sepiella maindroni de Rochebrune or golden cuttlefish, calcium carbonate 80~
85%, chitin, mucilaginous substance, a small amount of sodium chloride, calcium phosphate, magnesium salts etc., are a kind of resourceful natural mineral matters.Cuttlebone
It is to have edible and medical value Chinese medicine concurrently, gas raw meat, taste is micro- salty, and slightly warm in nature, returns liver and kidney channel, and there is astringing to arrest bleeding, controlling nocturnal emission with astringent drugs to stop
Band, relieving haperacidity sore etc. act on.
Cuttlebone is sea mollusk cuttlebone bone, has being adapted with its marine float habit, good three
Net structure is tieed up, can be suspended in water, component is calcium carbonate (aragonitic is crystalline), is relatively connect with the natural composition and structure of bone
Closely, there is obvious promotion bone defect healing effect.
Sodium bicarbonate (sodium acid carbonate) is a kind of white alkaline powder soluble easily in water, is generated after highly basic is neutralized with weak acid
Acid salt, carbon dioxide can be discharged by being combined with water.As a kind of water-soluble inorganic abrasive, it is not used alone generally, normal and carbon
Sour calcium etc. shares, and sodium bicarbonate (sodium acid carbonate) is added to the moisture having in toothpaste in cleaning whitening effect, with oral cavity well
Sodium carbonate can be generated with reference to after and shows special saline taste.
Below by specific embodiment, the present invention is further explained, but these embodiments are used only for that it is described in more detail
With, and be not applied to limit the present invention in any form.
Embodiment 1
A kind of toothpaste with low abrasion and high cleaning benefits, by weight percentage, includes following raw material components：
Manufacture craft is as follows：
1) parabens, essence are added in container A, stirring and dissolving；
2) deionized water is added in premix pot B, then adds saccharin sodium, zinc citrate, Cocoamidopropyl betaine
And stirring and dissolving；
3) polyethylene glycol, sorbierite are added in premix pot C；
4) by cuttlebone, sodium bicarbonate (sodium acid carbonate), sodium carboxymethylcellulose, melon glue, laruyl alcohol sodium sulfovinate, titanium white
Powder is added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, after the assay was approved can
Go out cream.
Embodiment 2
A kind of toothpaste with low abrasion and high cleaning benefits, by weight percentage, includes following raw material components：
Manufacture craft is as follows：
1) parabens, essence are added in container A, stirring and dissolving；
2) deionized water is added in premix pot B, then adds acesulfame potassium, button sweet tea, zinc citrate, sodium lauroyl sarcosine
And stirring and dissolving；
3) polyethylene glycol, sorbierite are added in premix pot C；
4) by cuttlebone, sodium bicarbonate (sodium acid carbonate), sodium carboxymethylcellulose, xanthans, laruyl alcohol sodium sulfovinate, titanium white
Powder is added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, after the assay was approved can
Go out cream.
Embodiment 3
A kind of toothpaste with low abrasion and high cleaning benefits, by weight percentage, includes following raw material components：
Manufacture craft is as follows：
1) deionized water is added in premix pot B, then adds saccharin sodium, sodium benzoate, zinc citrate and stirring and dissolving；
2) propane diols, glycerine, sorbierite are added in premix pot C；
3) by cuttlebone, sodium bicarbonate (sodium acid carbonate), sodium carboxymethylcellulose, xanthans, laruyl alcohol sodium sulfovinate, titanium white
Powder is added in meal mixer；
4) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
5) after vacuum outgas 30 minutes, essence is sucked, then homogeneous deaerates 10 minutes, can go out cream after the assay was approved.
Embodiment 4
A kind of toothpaste with low abrasion and high cleaning benefits, by weight percentage, includes following raw material components：
Manufacture craft is as follows：
1) deionized water is added in premix pot B, then adds saccharin sodium, sodium benzoate, zinc citrate, the CI77491 months
Osmanthus acylsarcosine sodium, Cocoamidopropyl betaine and stirring and dissolving；
2) polyethylene glycol, sorbierite are added in premix pot C；
3) by cuttlebone, sodium bicarbonate (sodium acid carbonate), silica, sodium carboxymethylcellulose, melon glue, laruyl alcohol sulfuric acid
Ester sodium is added in meal mixer；
4) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
5) after vacuum outgas 30 minutes, essence is sucked, then homogeneous deaerates 10 minutes, can go out cream after the assay was approved.
It is effete test embodiment content below.
1st, Physicochemical test part
Experimental example 1：Toothpaste study on the stability
By embodiment 1-4 toothpaste and the toothpaste of comparative example per 3, sample, it is put into 45 DEG C of baking ovens and investigates 3 months, monthly check 1
It is secondary.Toothpaste (sodium acid carbonate) containing sodium bicarbonate is contrasted, without cuttlebone as stabilizer, and using pyrophosphate as stabilizer.Toothpaste
Study on the stability is shown in Table 1.
1 toothpaste study on the stability of table
Result is investigated by table 1 to know：The toothpaste of embodiment 1-4 has good stability, though color and luster changes, in vision
In tolerance interval, consistency change splits observation in reasonable interval, soft, the viscous wall of lotion uniformly, without separation water outlet phenomenon.
And the toothpaste discoloration of comparative example is serious, consistency change is larger, splits within the 3rd month observation, and lotion glues wall inequality, a little
Harden, lotion portion separates walls.It can be seen from the above that cuttlebone, which stablizes sodium bicarbonate (sodium acid carbonate) positive effect, is better than pyrophosphate.
Experimental example 2：Different abrasive wear tests
Instrument：Grit analyzer is crossed after repacking.
The preparation of glue：1.5 parts of sodium carboxymethylcellulose is weighed, is added in 10 parts of propane diols, is dispersed with stirring uniformly
Afterwards, 89 parts of water are added, are stirred evenly, standing 4 is stand-by when small.
The preparation of abrasive suspension：The glue 30g prepared is weighed, 20g is added and is tested abrasive, stir evenly.
2 copper sheets that weighted, length and width and thickness are matched with particle test groove really up to the mark, are respectively put into two mills
Wipe in test trough, the same abrasive suspension of 15g is separately added into each test trough, put down friction column, open instrument toward regrinding
Wipe 100000 times, friction terminates, and cleans copper sheet with distilled water and dries, and is weighed again with assay balance.
Two copper sheet gross weights after subtracting friction with two copper sheet gross weights before test divided by 2 its average value, i.e. sample
Attrition value (mg).The copper sheet attrition value that table 2 is tested for several common abrasive this method.
The copper sheet attrition value that several common abrasives of table 2 are tested with this method
| Abrasive | Attrition value (mg) |
| Calcite in powder (325 mesh) | 18.46 |
| Calcium phosphate dibasic anhydrous | 22.14 |
| Dicalcium phosphate dihydrate | 8.64 |
| Height friction silica | 20.38 |
| Cuttlebone (before processing) | 6.04 |
| Cuttlebone (after processing) | 8.44 |
Known by table 1, the attrition value of cuttlebone is than relatively low, and high-grade abrasive material dicalcium phosphate dihydrate is relatively, specially treated
Cuttlebone it is more slightly higher than untreated attrition value, friction increased after illustrating specially treated.
Experimental example 3：Cleannes are tested
Test method：Make white plaque dyestain method by oneself.
Commercially available ceramic whiteware plate surface is subjected to the processing of friction roughening and makes roughness identical, so as to the attachment of spot.Will
The white plaque of roughening soaks 24h in homemade coffee stain, tea stain and smoke tar mixture, by the white plaque after immersion 50
DEG C oven drying 1h, to increase the adhesion of spot.24 essentially identical porcelain plates of dyestain are selected in range estimation, are randomly divided into six groups,
Every group of 4 parallel tests, the respectively toothpaste to embodiment 1-4 and commercial toothpastes (without two kinds of abrasives of the invention).
With the toothbrush of the same model of same brand, scrubbed with identical speed, same time, the tile after scrub is with clearly
Water dries after washing away bur, and whiteness is measured with whiteness instrument.Assuming that whiteness is considered as 0 after dyestain, every group of whiteness average value after scrub
It is considered as the cleannes (%) of the toothpaste, table 3 is the cleannes (%) of different toothpaste.
The cleannes (%) of the different toothpaste of table 3
| Sample | Cleannes (%) |
| Embodiment 1 | 95 |
| Embodiment 2 | 94 |
| Embodiment 3 | 90 |
| Embodiment 4 | 88 |
| Commercial toothpastes | 80 |
3 experimental data of table shows that toothpaste of the invention has good cleaning force.
Consolidated statement 2 and 3 experimental data of table show, natural abrasive composition toothpaste of the invention has low abrasion, noble and unsullied
The characteristics of tooth, a kind of safe oral cavity cleaning and nursing product is provided for the people of enamel hypoplasia or tooth wear.
2nd, clinical test part
Selection 70 meets inclusive criteria, is divided to two by target person progress equilibrium by Lobene color spots index, gender and age
Group, 35 people of test group, 35 people of control group.Test group is the toothpaste of embodiment 4, and control group is the formulation of tooth-paste of embodiment 4, mill
Liniment composition equivalent substitution is the toothpaste of other conventional abrasives.
Evaluated with Lobene color spot indexes, the size at color spot position and color spot degree evaluated with 0~3 numeral,
As table 4 checks labial surface of the tooth position for the lip of mandibular anterior teeth, lingual surface and premanillary teeth.Each facing is divided into two score area's (gums
Area and Ya Ti areas), score respectively by color spot size and color spot degree.
The color spot score in each area is scored for color spot size and the product of color spot degree score, the color spot score of each facing
For the average value of the score of gum area and the score of Ya Ti areas, the color spot index meter of each subject is divided into the flat of each stain on the tooth surface score
Average.
The classification of table 4Lobene color spots index is scored
| Classification score | Size | Degree |
| 0 | No color spot exists | No color spot exists |
| 1 | Color spot is no more than the 1/3 of facing | Slight color spot (yellow or yellowish-brown) |
| 2 | Color spot is no more than the 2/3 of facing | Moderate color spot (moderate brown) |
| 3 | Color spot is more than the 2/3 of facing | Severe color spot (dark-brown or black) |
Statistical analysis is carried out using SPSS13.0 statistical softwares.Differentiate that two group differences are with two independent sample rank sum tests
No to have significant, using two-sided test, a values are set to 0.05.Baseline, Lobene color spots index is shown in Table 5 after 4 weeks.
Table 5Lobene color spot indexes compare
| Control group (x ± s) | Test group (x ± s) | |
| Baseline | 3.474±0.92 | 3.080±0.80 |
| After 4 weeks | 2.860±0.90 | 2.221±0.72 |
From the result of above-mentioned table 4 and table 5, two groups of subjects Lobene color spots index in baseline is examined through statistics
Test, there was no significant difference between control group and test group (P=0.071), is comparable.After 4 weeks, control group Lobene color spots refer to
Number decline 17.67% compared with baseline, test group Lobene color spot indexes decline 27.89% compared with baseline, is examined through statistics
Test, control group and test group Lobene color spot index differentials are statistically significant (P=0.037).
For 4 toothpaste of embodiment compared with control group toothpaste, the decline of Lobene color spot indexes has significant difference (P ＜
0.05), illustrate that 4 toothpaste of embodiment has the clinical effectiveness for reducing the exogenous color spot pigment of facing.
Above example only expresses the several embodiments of the present invention, is not construed as limitation of the present invention, the present invention
Protection domain should be subject to claim limited range.For those skilled in the art, exist
Under the conditions of not departing from the spirit and scope of the present invention, the appropriate change of some conditions can be carried out, however it is not limited to the present invention disclose and
The embodiment of description, and should be attributed to scope of the claims.
Claims (9)
- A kind of 1. toothpaste with low abrasion and high cleaning benefits, it is characterised in that：By weight percentage, comprising 20~40% Abrasive composition, moisturizer, thickener, surfactant, sweetener, preservative, essence, deionized water etc..
- 2. the toothpaste according to claim 1 with low abrasion and high cleaning benefits, it is characterised in that：The abrasive group Compound includes 5~20% cuttlebone, 10~30% sodium bicarbonate (sodium acid carbonate).
- 3. the toothpaste according to claim 1 with low abrasion and high cleaning benefits, it is characterised in that：By weight percentage Meter, also comprising 40~60% moisturizer, 1.0~1.2% thickener, 2~3% surfactant, 0.15~0.3% Sweetener, 0.15~0.3% preservative, 1.0~1.5% essence, deionized water are added to 100%.
- 4. the toothpaste according to claim 2 with low abrasion and high cleaning benefits, it is characterised in that：The cuttlebone is Degreasing is carried out to cuttlebone and takes off the obtained natural abrasive of albumen processing.
- 5. the toothpaste according to claim 4 with low abrasion and high cleaning benefits, it is characterised in that：The cuttlebone takes off Fat takes off albumen treatment process：Take fresh cuttlebone, retain inner core except decapsidate after dry, it is powdered to be ground into 100 mesh~150 mesh, adds 4~5 times of amounts 2%~4% NaOH aqueous solutions, capping boil after be cooked by slow fire 20~30 minutes, be cooled to room temperature, by filemot water cooking liquid Filter off, cuttlebone powder is rinsed with a large amount of clear water, untill water lotion is constant in water white transparency, continuous 3 water lotion pH, then pass through Dehydration is crossed, (105 DEG C) dryings of high temperature, grind, and the natural toothpaste abrasive of cuttlebone of 200~400 mesh is made.
- 6. the toothpaste according to claim 2 with low abrasion and high cleaning benefits, it is characterised in that：The sodium bicarbonate (sodium acid carbonate) is ultra tiny particle diameter, and size controlling is in 800~1000 mesh.
- 7. the toothpaste according to claim 3 with low abrasion and high cleaning benefits, it is characterised in that：The moisturizer is glycerine, one or more mixtures in sorbierite, polyethylene glycol, propane diols；The thickener is sodium carboxymethylcellulose, one or more mixtures in xanthans, melon glue；The surfactant is laruyl alcohol sodium sulfovinate, one kind in sodium lauroyl sarcosine, Cocoamidopropyl betaine Or a variety of mixtures；The sweetener is saccharin sodium, one or more mixtures in acesulfame potassium, button sweet tea；The preservative is one or both of sodium benzoate, parabens mixture.
- 8. according to the toothpaste according to any one of claims 1 to 7 with low abrasion and high cleaning benefits, it is characterised in that： In order to mitigate sodium bicarbonate (sodium acid carbonate) toothpaste discoloration problem, a small amount of zinc citrate is also added, its additive amount should ensure that lotion PH is more than 8.3.
- 9. according to the toothpaste according to any one of claims 1 to 7 with low abrasion and high cleaning benefits, it is characterised in that： Further, appearance modifying agents and suitable silica or other conventional abrasives, the appearance modifying agents bag can also be added Containing titanium dioxide, pigment.
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| CN112641993A (en) * | 2020-12-22 | 2021-04-13 | 安徽徽科生物工程技术有限公司 | Hemostatic filling material for dental fossa |
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| CN112516175A (en) * | 2020-12-22 | 2021-03-19 | 安徽徽科生物工程技术有限公司 | Cuttlebone treatment method, cuttlebone product and hemostasis and healing promotion material |
| CN112641993A (en) * | 2020-12-22 | 2021-04-13 | 安徽徽科生物工程技术有限公司 | Hemostatic filling material for dental fossa |
| CN112641993B (en) * | 2020-12-22 | 2022-03-15 | 安徽徽科生物工程技术有限公司 | Hemostatic filling material for dental fossa |
| CN112516175B (en) * | 2020-12-22 | 2022-06-21 | 安徽徽科生物工程技术有限公司 | Cuttlebone treatment method, cuttlebone product and hemostasis and healing promotion material |
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Application publication date: 20180504 |