CN110742815B

CN110742815B - An oral care composition with high cleaning ability and low abrasion value

Info

Publication number: CN110742815B
Application number: CN201810818920.2A
Authority: CN
Inventors: 叶德成; 高琳; 陈晓斌
Original assignee: Hawley & Hazel Bvi Co ltd
Current assignee: Hawley & Hazel Bvi Co ltd
Priority date: 2018-07-24
Filing date: 2018-07-24
Publication date: 2022-09-27
Anticipated expiration: 2038-07-24
Also published as: CN110742815A

Abstract

An oral care composition having high cleaning power and low abrasion value comprises abrasive silica and baking soda having a particle size of between 10 and 250 microns. The oral care composition has the characteristics of high cleaning ability and small abrasion value, and particularly, the cleaning ability PCR of the oral care product is more than or equal to 85; and PCR/RDA is more than or equal to 0.90.

Description

Oral care composition with high cleaning ability and low abrasion value

Technical Field

The invention relates to the technical field of oral care, in particular to an oral care composition with high cleaning capability and small abrasion value.

Background

The abrasive is an important component of the formula of the oral care product, and can play a role in cleaning, smoothing and brightening the tooth surface and removing pigmentation, bacterial plaque deposition and detention. An ideal abrasive would be highly cleansing and not damaging to the tooth surface.

The oral care industry typically evaluates the performance of abrasives using both cleaning ability and wear value.

Tooth cleaning ability is generally evaluated by a biofilm cleaning rate experimental model (PCR). The model is reported by American Indiana university in 1982, is used for evaluating the effect of removing the exogenous stains from teeth, the PCR result has good correlation with clinical experiments (r is 0.85), and PCR is widely used in European and American toothpaste industries for evaluating the effect of physically removing the exogenous stains from the toothpaste.

The abrasion value is generally evaluated by using a Relative dentin abrasion value (RDA). Because of the higher hardness of enamel, the abrasive is less damaging to the enamel, and abrasion occurs primarily in the dentin. Currently, the RDA value is generally determined by using a radioactive loss method, and both ISO1609 and the US FDA require that the RDA value of the toothpaste tested by using the method can not exceed 250.

An ideal oral care product, such as toothpaste, should have a high PCR value on one hand, and be able to clean the oral cavity and remove dental plaque; on the other hand, the RDA value cannot be too high, which may cause dentin abrasion and damage to teeth. The abrasive agents are cleaned in a physical friction mode, and some abrasive agents have strong cleaning capability but higher abrasion values; some abrasives have poor friction capability and low abrasion value, but cannot achieve the effect of cleaning teeth.

The higher the PCR value for the abrasive system in the oral care product, the better the RDA value. PCR/RDA is the ratio of the PCR value to the RDA value of an oral care product (e.g., toothpaste), reflecting the strength of the cleaning ability of a toothpaste per unit dentin abrasion value. The greater the PCR/RDA value, the greater the cleaning power of the toothpaste given the unit dentin abrasion. For whitening toothpaste, after the target PCR value is reached and the RDA is not more than 250, the larger the PCR/RDA value is, the better the PCR/RDA value is. The PCR/RDA can effectively reflect the strength of the cleaning capability of the friction system in the formula on the premise of not damaging teeth.

Chinese patent application CN 107519026A discloses a dentifrice with stain removing and breath freshening functions and a preparation method thereof. This document has introduced that dentifrice product has strong, the clean effectual advantage of friction power than oral cavity cleaning care products such as toothpaste, mouthwash, for some have tooth stain consumers and like, but current dentifrice product is too much because its abrasive addition volume, also relatively great to the wearing and tearing of tooth when having high cleaning power, for solving this problem, this document provides following technical scheme, a dentifrice with stain removal and fresh breath, by following mass percent's each component: 1-10% of a humectant; 70-90% of compound abrasive; 2-8% of foaming agent; the balance of water. The composite abrasive comprises activated carbon and a second abrasive component, wherein the second abrasive component is at least one of silicon dioxide, calcium carbonate and calcium hydrophosphate dihydrate.

Therefore, in oral care products, a correlation between cleaning ability and abrasion value has been studied, but the technical solution of the above publication is applicable only to dentifrice, and there is no suitable technical solution for general oral care products (e.g., toothpaste).

Disclosure of Invention

The technical problem to be solved by the present application is to provide an oral care composition with high cleaning ability and low abrasion value. The oral care composition has the characteristics of high cleaning ability and small abrasion value, and particularly, the cleaning ability PCR of the oral care product is more than or equal to 85; and PCR/RDA is more than or equal to 0.90.

In order to solve the technical problem, the invention adopts the following technical scheme:

an oral care composition with high cleaning ability and low abrasion value comprises abrasive silica and baking soda having a particle size of 10-250 microns, preferably 30-200 microns.

Preferably, the silica comprises from 2 to 30wt% of the oral care composition.

More preferably, the silica comprises 5 to 25wt% of the oral care composition.

Most preferably, the silica comprises 10-20% of the oral care composition.

Preferably, the baking soda comprises 2 to 20 wt% of the oral care composition.

More preferably, the baking soda comprises 5-15wt% of the oral care composition.

Most preferably, the baking soda comprises 10% to 15% by weight of the oral care composition.

Preferably, the weight ratio of the silicon dioxide to the baking soda is 9:1-1: 9.

More preferably, the weight ratio of silica to baking soda is from 4:1 to 1: 4.

As a further improvement of the technical solution, the oral care composition further comprises coconut oil.

Preferably, the coconut oil is present in an oral care composition at a percentage of 0.05 to 3 wt%.

Preferably, the oral care composition is applicable in a toothpaste or gel.

Any range recited herein is intended to include the endpoints and any number between the endpoints and any subrange subsumed therein or defined therein.

The starting materials of the present invention can be obtained commercially, unless otherwise specified, and the equipment used in the present invention can be carried out by conventional equipment in the art or by referring to the prior art in the art.

Compared with the prior art, the invention has the following beneficial effects:

the oral care composition has the characteristics of high cleaning ability and small abrasion value, and particularly, the cleaning ability PCR of the oral care product is more than or equal to 85; and PCR/RDA is more than or equal to 0.90.

Detailed Description

In order to more clearly illustrate the invention, the invention is further described below in connection with preferred embodiments. It is to be understood by persons skilled in the art that the following detailed description is illustrative and not restrictive, and is not to be taken as limiting the scope of the invention.

The oral care composition with high cleaning capability and small abrasion value comprises abrasive silica and baking soda, wherein the particle size of the baking soda is between 10 and 250 micrometers.

Friction type silicon dioxide

The silicas that can be used in the practice of the present invention are abrasive silicas, particularly those available under the names Zeodent (R)105, 120, 115, 114, 113, Spherilex (TM) from Evonic, Sylodent (R)750, 753, 756, 783, SM850C, Syloblanc (R)81 from Grace, Sorbosil AC 73, 77, 43, 35, 39, 44 from Inc., MIA, MIG, etc. from Jinshanjiang.

Baking soda

Baking soda, i.e. sodium bicarbonate, chemical formula NaHCO ₃ Having a solubility of 10g/100ml at 25 ℃ and useful as an abrasive in oral care products, the baking soda suitable for the present invention has a particle size of between 10 and 250 microns, preferably between 30 and 200 microns, more preferably between 50 and 150 microns.

Surprisingly, it has been found that the cleaning ability of an oral care composition can be improved with a low abrasion value by combining a specific particle size of baking soda with abrasive silica. In the invention, the high cleaning capability means that the PCR is more than or equal to 85; the small abrasion value means that the PCR/RDA is more than or equal to 0.90.

In certain embodiments of the present invention, the silica comprises from 2 to 30wt% of the oral care composition.

In certain preferred embodiments of the present invention, the silica comprises 5 to 25wt% of the oral care composition.

In certain most preferred embodiments of the present invention, the silica comprises 10-20% of the oral care composition.

In certain embodiments of the present invention, the baking soda comprises 2 to 20 wt% of the oral care composition.

In certain preferred embodiments of the present invention, the baking soda comprises 5-15wt% of the oral care composition.

In certain most preferred embodiments of the present invention, the baking soda comprises 10% to 15% by weight of the oral care composition.

In certain embodiments of the invention, the weight ratio of silica to baking soda is from 9:1 to 1: 9.

In certain preferred embodiments of the present invention, the weight ratio of the silica to the baking soda is from 4:1 to 1: 4.

In certain embodiments of the present invention, the oral care composition further comprises coconut oil.

In certain embodiments of the present invention, the percentage of coconut oil in the oral care composition is 0.05-3wt%, preferably 0.05-2.5%, more preferably 0.1-2%, more preferably 0.3-1.5%, most preferably 0.5-1.0%.

In certain embodiments of the present invention, the oral care composition may further comprise adjuvants such as humectants, flavoring agents, and/or thickening agents.

In certain embodiments of the present invention, the oral care composition may further comprise active ingredients such as antibacterial agents, anticaries agents, anti-sensitivity agents, anticalculus agents, and/or whitening agents.

The oral care compositions of the present invention may be applied in a toothpaste or gel.

"humectants" are ingredients that prevent the oral care composition from becoming dehydrated and hardened. Exemplary humectants include, but are not limited to, such as glycerin, propylene glycol, sorbitol, low molecular weight polyethylene glycols, and the like. The humectant is typically present in the oral care composition in an amount of 10 to 80% by mass.

A "thickener" is a substance that increases the viscosity of a solution or liquid/solid mixture, but does not substantially change its properties. The purpose of the thickener is to provide skeleton, flow and stability to the product. Exemplary thickening agents include, but are not limited to, one or more of hydroxyethylcellulose, carboxymethylcellulose and salts thereof (e.g., sodium carboxymethylcellulose), carrageenan (carrageenan), carboxyvinyl polymers, xanthan gum (xanthan g μm), carrageenan, gelatin, pullulan, sodium alginate, and the like. In certain embodiments, the thickening agent comprises one or more of xanthan gum, carrageenan, or sodium carboxymethyl cellulose. The proportion by weight of thickener in the oral care composition is typically from 0.2 to 2%.

The "surfactant" serves the purpose of emulsifying the flavor and foaming in the toothpaste, and to some extent can assist in the sufficient and complete dispersion of the hydroxyapatite-polycarboxyl compound complex. Exemplary surfactants include, but are not limited to, anionic surfactants such as sodium dodecyl sulfate; amphoteric surfactants such as betaine; amino acid surfactants such as sodium sarcosinate lauryl alcohol and nonionic surfactants such as polyoxyethylene and polyoxypropylene copolymers, polyethylene glycol, and the like. The proportion by weight of the surfactant in the oral care composition is typically from 0.5 to 2.5%.

According to certain embodiments of the present application, active ingredients such as antibacterial agents, anticaries agents, anti-sensitivity agents, anticalculus agents, and/or whitening agents may further be included in the oral care compositions;

by "antibacterial agent" is meant a chemical substance that is capable of maintaining the growth or reproduction of certain microorganisms in an oral care composition below a necessary level over a period of time. Exemplary antimicrobial agents include, but are not limited to: stannous chloride, tetrahydrocurcumin, cetylpyridinium chloride, triclosan, and the like.

"anticaries agent" means a substance having a cariogenic inhibitory action, for example, a substance that enhances the anticaries ability of teeth by reducing the solubility of enamel hydroxyapatite, or a substance that controls plaque, inhibiting bacterial growth. Exemplary anticaries agents include, but are not limited to, phosphorus-containing agents (calcium phosphate, sodium trimetaphosphate, magnesium glycerophosphate, calcium lactate phosphate, sodium caseinate, etc.), or arginine and its derivatives. Preferably, in certain embodiments, the anticaries agent comprises a fluoride ion source.

An "anti-sensitivity agent" refers to a substance that prevents or treats dentinal hypersensitivity by inhibiting nerve impulses or being able to close dentinal tubules or reduce their permeability. Exemplary anti-sensitivity agents include, but are not limited to: potassium ion sources such as dipotassium glycyrrhizinate, potassium fluoride, potassium nitrate, potassium chloride and the like. Preferably, in certain embodiments, the anti-sensitivity agent comprises a source of potassium ions.

"anticalculus agent" refers to a metal ion complex that acts to combat dental calculus. Exemplary anticalculus agents include, but are not limited to: pyrophosphate, tripolyphosphate, hexametaphosphate or citrate.

The "whitening agent" refers to a substance having a whitening effect on teeth. Exemplary whitening agents include, but are not limited to: peroxide bleaching agent, papain and glucose oxidase.

Examples 1 to 5:

an oral care composition was formulated into a toothpaste according to the following formulation of table 1 by conventional methods.

The detection result shows that:

	example 1	Example 2	Example 3	Example 4	Example 5
						PCR	108	66	106	96	105
RDA	149	88	115	124	133
						PCR/RDA	0.72	0.75	0.92	0.77	0.79

As can be seen from example 1, when only attrition type silica is used, excluding baking soda, the PCR/RDA is ≦ 0.8; as can be seen from example 2, the PCR/RDA is also ≦ 0.8 when only baking soda with a d ═ 10-250 μm, excluding attrition silica; as can be seen from example 4, when using attrition type silica, baking soda is also used, but the particle size of baking soda is less than 10 μm, and the PCR/RDA is still less than or equal to 0.8; as can be seen from example 5, when attrition type silica is used, baking soda is also used, but the particle size of baking soda is more than 250 μm, the PCR/RDA is still less than or equal to 0.8; as can be seen from example 3, when attrition-type silica is used, as is baking soda, and the particle size of baking soda is between 10 and 250. mu.m, the PCR/RDA is 0.9 or more.

Examples 6 to 11

The detection result shows that:

	example 6	Example 3	Example 7	Example 8	Example 9	Example 10	Example 11
								PCR	104	103	97	85	73	103	85
RDA	132	113	105	92	90	112	93
								PCR/RDA	0.79	0.91	0.92	0.92	0.81	0.92	0.91

As can be seen from example 6, the PCR/RDA is 0.8 or less at a 9:1 attrition silica to baking soda weight ratio; as can be seen from example 8, the PCR/RDA is 0.8 or less at a 1:9 weight ratio of abrasive silica to baking soda; (ii) a As can be seen from examples 3, 7, 10 and 11, the PCR/RDA ratio was 0.9 or more at a weight ratio of 4:1 to 1-4 between the abrasive silica and the baking soda.

Examples 12 to 14

The detection result shows that:

	example 12	Example 13	Example 14
				PCR	87	137	186
RDA	95	151	204
				PCR/RDA	0.92	0.91	0.91

As can be seen from the examples, the PCR value increases with the addition of silica and baking soda, and when the addition of silica is up to 30% and the addition of baking soda is up to 15%, the RDA value is not over 250, and the PCR/RDA is greater than or equal to 0.9.

Examples 15 to 17

An oral care composition was formulated into a toothpaste according to the following formulation in table 1, by conventional methods.

The detection result shows that:

	example 15	Example 16	Example 17	Example 18	Example 19
						PCR	137	139	142	147	148
RDA	151	152	152	151	150
						PCR/RDA	0.91	0.91	0.95	0.97	0.99

As can be seen from the examples, the coconut oil added in the oral care product of the invention can have larger PCR value, and the RDA value is basically kept unchanged, and the PCR/RDA is more than or equal to 0.9.

It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Not all embodiments are exhaustive. Obvious changes and modifications of the technical scheme of the invention are included in the protection scope of the invention.

Claims

1. An oral care composition having high cleaning ability and low abrasion value comprising abrasive silica, baking soda and coconut oil, wherein the baking soda has a particle size of 10 to 250 microns;

the silica comprises from 2 to 30wt% of the oral care composition;

the baking soda comprises 5-15wt% of the oral care composition;

the weight ratio of the silicon dioxide to the baking soda is 4:1-1: 4;

the abrasive silica was Zeodent105 or AC 77.

2. The oral care composition of claim 1, wherein: the silica comprises 5-25wt% of the oral care composition.

3. The oral care composition of claim 2, wherein: the silica is present in the oral care composition in an amount of 10 to 20%.

4. The oral care composition of claim 1, wherein: the baking soda accounts for 10-15 wt% of the oral care composition.

5. The oral care composition of claim 1, wherein: the coconut oil is present in the oral care composition at a percentage of 0.05 to 3 wt%.

6. The oral care composition of claim 1, wherein: the oral care composition may be applied in a toothpaste or gel.