CN107468587A - It is a kind of to include the oral care composition for stablizing polyphenol - Google Patents
It is a kind of to include the oral care composition for stablizing polyphenol Download PDFInfo
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- CN107468587A CN107468587A CN201710825673.4A CN201710825673A CN107468587A CN 107468587 A CN107468587 A CN 107468587A CN 201710825673 A CN201710825673 A CN 201710825673A CN 107468587 A CN107468587 A CN 107468587A
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- Prior art keywords
- stannous
- oral care
- acid
- salt
- care composition
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Abstract
The invention discloses a kind of comprising the oral care composition for stablizing polyphenol, including at least polyphenol compound and stannous ion source, the pH of composition is 58.The oral care composition of the present invention and the product including said composition can ensure that stability is present, and after being placed one month in 25 DEG C of environment, EGCg surplus can reach 86% in Tea Polyphenols.
Description
Technical field
The present invention relates to oral care techniques field, is combined more particularly, to a kind of comprising the oral care for stablizing polyphenol
Thing.
Background technology
Plant extracts containing polyphenol has been widely used in the oral care products such as toothpaste, such as tea extract, city
Existing tooth paste product of more moneys containing tea extract, is loved by consumers on field.But the molecular structure in polyphenol compound
In contain multiple phenolic hydroxyl groups, be oxidized easily and formed complexity quinones, cause polyphenol to lose original antioxygenic property, and
Oral cavity composition is caused to change colour.So need to improve the stability in oral care product.
The content of the invention
The application technical problems to be solved are to provide a kind of comprising the oral care composition for stablizing polyphenol.This composition
The presence of stability can be ensured, after being placed one month in 25 DEG C of environment, EGCg surplus can reach in Tea Polyphenols
86%.
In order to solve the above technical problems, the present invention adopts the following technical scheme that:
It is a kind of to include the oral care composition for stablizing polyphenol, including at least polyphenol compound and stannous ion source, institute
The pH for stating composition is 5-8.
According to some preferred embodiments of the application, the pH of the composition is 5-7.5;
According to some preferred embodiments of the application, the pH of the composition is 5-7;
According to some preferred embodiments of the application, the pH of the composition is 6-7.
According to some embodiments of the application, composition further comprises pH adjusting agent, to ensure the composition
PH be 5-8 in the range of.
According to some preferred embodiments of the application, the pH adjusting agent includes but is not limited to sodium hydroxide, hydrochloric acid, sulphur
Acid, citric acid and its salt, lactic acid and its salt, phosphoric acid and its salt, phthalic acid and its salt, pyrophosphoric acid and its salt, tripolyphosphate
And its salt, polyphosphoric acids and its salt, citric acid and its salt, acetic acid and its salt.
According to some embodiments of the application, the polyphenol compound includes following one or more kinds of chemical combination
Thing:Epigallo-catechin gallate (EGCG) (EGCg), L-Epicatechin gallate (ECG), catechuic acid (Catechin), table
Catechin (Epicatechin, EC) and epigallocatechin (EGC) and chlorogenic acid;
According to some embodiments of the application, it is Tea Polyphenols that the polyphenol, which carrys out compound,
According to some embodiments of the application, the mass ratio of the stannous ion source and polyphenol compound is more than 5:
1。
According to some preferred embodiments of the application, the mass ratio of the stannous ion source and polyphenol compound is big
In 10:1.
According to some most preferred embodiments of the application, the mass ratio of the stannous ion source and polyphenol compound is
More than 100:1.
According to some embodiments of the application, addition of the polyphenol compound in oral care composition is
0.0001-0.2wt%.
According to some embodiments of the application, the stannous ion source is in the addition of oral care composition
0.001-1wt%.
According to some embodiments of the application, abrasive, moisturizing can be further comprised in the oral care composition
The auxiliary material such as agent and/or thickener;
According to some embodiments of the application, antiseptic, anti-caries can be further comprised in the oral care composition
Agent, anti-sensitizer, antilithic and/or whitening agent isoreactivity composition;
Any scope described in the present invention includes any numerical value and end value or end value between end value and end value
Between any subrange for being formed of any number.
Unless otherwise specified, each raw material in the present invention can be obtained by commercially available purchase, equipment used in the present invention
The conventional equipment in art or the prior art with reference to art can be used to carry out.
Compared with prior art, the present invention has the advantages that:
After being placed one month in 25 DEG C of environment, EGCg surplus can reach 86% in Tea Polyphenols.
Embodiment
In order to illustrate more clearly of the present invention, with reference to preferred embodiment, the present invention is described further.Ability
Field technique personnel should be appreciated that following specifically described content is illustrative and be not restrictive, and this should not be limited with this
The protection domain of invention.
The present invention is a kind of comprising the oral care composition for stablizing polyphenol, including at least polyphenol compound and stannous ion
Source, the pH of the composition is 5-8.
Applicant is found surprisingly that, the composition pH regulations including polyphenol compound and stannous ion source are maintained into 5-
Between 8, the stability of composition can be increased substantially.
According to some preferred embodiments of the application, the pH of the composition is 5-7.5, and the stability of said composition is more
To be superior.
According to some preferred embodiments of the application, the pH of the composition is 5-7;The stability of said composition is special
It is superior.
According to some preferred embodiments of the application, the pH of the composition is 6-7.The stability of said composition is the most
It is superior.
According to some preferred embodiments of the application, it may include pH adjusting agent in the composition, to by composition
PH is adjusted between 5-8.
According to some preferred embodiments of the application, the pH adjusting agent includes but is not limited to sodium hydroxide, hydrochloric acid, sulphur
Acid, citric acid and its salt, lactic acid and its salt, phosphoric acid and its salt, phthalic acid and its salt, pyrophosphoric acid and its salt, tripolyphosphate
And its salt, polyphosphoric acids and its salt, citric acid and its salt, the one or more in acetic acid and its salt.
According to some embodiments of the application, the polyphenol compound includes following one or more kinds of chemical combination
Thing:Epigallo-catechin gallate (EGCG) (EGCg), L-Epicatechin gallate (ECG), catechuic acid (Catechin), table
Catechin (Epicatechin, EC) and epigallocatechin (EGC) and chlorogenic acid;
According to some embodiments of the application, it is Tea Polyphenols that the polyphenol, which carrys out compound,
According to some embodiments of the application, the mass ratio of the stannous ion source and polyphenol compound is more than 5:
1, or for more than 10:1, or for more than 15:1, or for more than 20:1, or for more than 25:1, or for more than 30:1, or for more than
35:1, or for more than 40:1, or for more than 45:1, or for more than 50:1, or for more than 55:1, or for more than 60:1, or be big
In 65:1, or for more than 70:1, or for more than 75:1, or for more than 80:1, or for more than 85:1, or for more than 90:1, or be
More than 100:1.But maximum is no more than 1000:1.
According to some embodiments of the application, addition of the polyphenol compound in oral care composition is
0.0001-0.2wt%.
According to some embodiments of the application, the stannous ion source is in the addition of oral care composition
0.001-1wt%.
According to some embodiments of the application, abrasive, moisturizing can be further comprised in the oral care composition
The auxiliary material such as agent and/or thickener;
" abrasive " is the body material of toothpaste, typically constitutes from the 20%-50% of formula, most important in toothpaste to act on just
It is to remove tartar, mitigates calculus dentalis.The selection of abrasive should consider its hardness, size, shape and content comprehensively, it is ensured that effectively clear
Clean formula does not wear tooth.The abrasive of example may include but be not limited to following one or more:Calcium carbonate, phosphoric acid hydrogen
Calcium, calcium pyrophosphate, tricalcium phosphate, alumina silicate, aluminium hydroxide, aluminum oxide, zeolite, titanium oxide, silicic acid, kaolin etc..
" NMF " is the composition for preventing oral care composition dehydration to be hardened.The NMF of example includes but is not limited to such as
Glycerine, propane diols, sorbierite, the polyethylene glycol etc. of low molecule amount.By mass percentage, NMF is in oral care composition
In content be usually 10-80%.
" thickener " is a kind of auxiliary rheological agents, can not only thicken coating, prevents sagging phenomenon occur in construction, and
The excellent mechanical performance of coating and bin stability can be assigned.Published thickener various types in the prior art, including nothing
Machine thickener, cellulose family, polyacrylate and the class of association type polyurethane thickener four.Cellulose thickener includes but unlimited
In methylcellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose etc..Polyacrylic ester thickener point
For two kinds:One kind is water miscible polyacrylate;Another kind is the homopolymer or copolymer emulsion of acrylic acid, methacrylic acid
Thickener, this thickener are acid in itself, must be neutralized to pH=8-9 with alkali or ammoniacal liquor and can be only achieved thickening effect, also referred to as
For acrylic acid alkali swollen thickener.Polyurethanes thickener is association thickener newly developed in recent years.Inorganic thickening agent is
A kind of water swelling and form thixotropic gel mineral.The inorganic thickening agent of example includes but is not limited to bentonite, concave convex rod
Soil, alumina silicate etc..
According to some embodiments of the application, antiseptic, anti-caries can be further comprised in the oral care composition
Agent, anti-sensitizer, antilithic and/or whitening agent isoreactivity composition;
" antiseptic " is the growth or breeding for referring within a certain period of time, make certain micro-organisms in oral care composition
It is maintained at necessary chemical substance below horizontal.The antiseptic of example includes but is not limited to:Zinc oxide, stannous chloride, tetrahydrochysene ginger
Flavine, cetylpyridinium chloride, triclosan etc..
" anti-caries agent " refers to the material for having inhibitory action to dental caries, such as can be by reducing enamel hydroxyapatite
The material of the anti-caries ability of solubility enhancing tooth, or control bacterial plaque, the material of bacteria growing inhibiting.The anti-caries agent of example includes
But it is not limited to, fluoride ion source (e.g., sodium fluoride, potassium fluoride, calcirm-fluoride, magnesium fluoride, stannous fluoride, ammonium fluoride, single fluorophosphoric acid
Sodium, single fluorophosphoric acid potassium, fluosilicate etc.), phosphorus reagent (calcium phosphate, sodium trimetaphosphate, magnesium glycerophosphate, calcium lactophosphate, junket egg
White acid sodium etc.) or arginine and its derivative.Preferably, in some embodiments, the anti-caries agent includes fluoride
Ion gun.
" anti-sensitizer " refers to by suppressing nerve impulse or can close dentinal tubule or reduce its permeability, so as to pre-
Anti- or treatment dental hypersensitiveness material.The anti-sensitizer of example includes but is not limited to:Dipotassium glycyrrhizinate, potassium fluoride, potassium nitrate,
The potassium ion sources such as potassium chloride.Preferably, in some embodiments, the anti-sensitizer includes potassium ion source.
" antilithic " refers to the metal ion complex that can play a part of anti-tooth calculus.The antilithic bag of example
Include but be not limited to:Pyrophosphate, tripolyphosphate, hexametaphosphate or citrate.
" whitening agent " refers to the material that whitening function can be played to tooth.The whitening agent of example includes but is not limited to:Peroxide
Compound bleaching agent, papain, glucose oxidase.
The Detection of Stability method of oral care composition of the present invention is to be based on:Tea Polyphenols is mixture, wherein comprising more
The different polyphenol compound of kind, such as Epigallo-catechin gallate (EGCG) (EGCg), L-Epicatechin gallate
(ECG), catechuic acid (Catechin), epicatechin (Epicatechin, EC) and epigallocatechin (EGC).Tea Polyphenols
Content can with EGCg content come characterize indirectly.EGCg is a kind of main biologically active monomer in Tea Polyphenols.EGCg passes through
Method well known in the art is measured.For example, detected by HPLC-MS-MS or LC-MS method.
Embodiment 1- embodiments 8:Oral care composition
1mol/L sodium hydroxide solution and 1mol/L pyrophosphate solution are prepared, respectively obtains two kinds of solution mixed preparings
PH2.0, pH4.0, pH5.0, pH6.0, pH7.0, pH7.5, pH8.0, pH10.0 cushioning liquid.
The raw material and content of embodiment 1-8 compositions see the table below 1:
Table 1
Accountings of the wherein EGCg in tea polyphenol raw materials is 64.2%.
Embodiment 1-8 Detection of Stability result such as table 2 below:
Above-mentioned formulation Example 1-8 composition is respectively placed in 25 DEG C, 40 DEG C and 50 DEG C of environment, and is placing one
EGCg contents therein are tested with HPLC methods respectively when individual month (aging), to assess the stability of Tea Polyphenols.Test result shows
Show in table 2.
Table 2, the EGCg testing results (%) after embodiment 1-8 compositions aging 1 month
Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | |
25℃ | 0.0471 | 0.0553 | 0.0613 | 0.0632 | 0.0629 | 0.0638 | 0.0536 | 0.0559 |
40℃ | 0.0329 | 0.0415 | 0.0597 | 0.0611 | 0.0601 | 0.0593 | 0.0366 | 0.0407 |
50℃ | 0.0196 | 0.0289 | 0.0562 | 0.0579 | 0.0553 | 0.0572 | 0.0214 | 0.0268 |
Embodiment 9-13:Oral care composition
1mol/L sodium hydroxide solution and 1mol/L pyrophosphate solution are prepared, respectively obtains two kinds of solution mixed preparings
PH7.0 cushioning liquid.
Embodiment 9-13 composition material and content see the table below 3:
Table 3:
Accountings of the wherein EGCg in tea polyphenol raw materials is 64.2%.
Embodiment 9-13 composition Detection of Stability result such as table 4 below:
Table 4:EGCg testing results (ppm) after embodiment 9-13 compositions aging 1 month
Embodiment 9 | Embodiment 10 | Embodiment 11 | Embodiment 12 | Embodiment 13 | |
25℃ | 0 | 39 | 51 | 64 | 63 |
40℃ | 0 | 19 | 29 | 59 | 61 |
50℃ | 0 | 0 | 11 | 53 | 57 |
Embodiment 14
A kind of mouthwash formula, include the raw material of following percentage by weight:
Accountings of the wherein EGCg in tea polyphenol raw materials is 64.2%.
The pH of above-mentioned formula is 7.5.Placed one month under the conditions of 25 DEG C, the content that can detect EGCg is 6ppm.
Embodiment 15
A kind of toothpaste, include the raw material of following percentage by weight:
Accountings of the wherein EGCg in tea polyphenol raw materials is 64.2%.
Oral care composition can be made in above-mentioned raw materials using method conventional in the prior art -- such as toothpaste.
The pH of above-mentioned formula is 7.1.Placed one month under the conditions of 25 DEG C, detectable EGCg content is
0.0613%.
Comparative example 1-8:
Chinese patent application CN10607419A, which is disclosed, contains free alkaline earth metal ion, stannous ion and polyphenol
Oral care composition, composition can improve the stability of polyphenol.Comparative example 1-8 compares different pH to polyphenol in said composition
The influence of stability.
1mol/L sodium hydroxide solution and 1mol/L pyrophosphate solution are prepared, respectively obtains two kinds of solution mixed preparings
PH9.5.0, pH7.50, pH7.0, pH6.5, pH5.5, pH4.5, pH7.03.5, pH1.5, cushioning liquid.
Table 5:Component and raw material proportioning table in comparative example 1-8 compositions
Accountings of the wherein EGCg in tea polyphenol raw materials is 64.2%.
Table 6, the EGCg testing results (%) after comparative example 1-8 compositions aging 1 month
As can be seen here, in the oral care composition comprising stannous ion source and polyphenol, except alkaline-earth metal ions (such as
Calcium ion) stablizing outside sexual influence on composition, pH value range also has substantial effect to composition stability.
Obviously, the above embodiment of the present invention is only intended to clearly illustrate example of the present invention, and is not pair
The restriction of embodiments of the present invention.For those of ordinary skill in the field, may be used also on the basis of the above description
To make other changes in different forms.Here all embodiments can not be exhaustive.It is every to belong to this hair
Row of the obvious changes or variations that bright technical scheme is extended out still in protection scope of the present invention.
Claims (10)
1. a kind of include the oral care composition for stablizing polyphenol, it is characterised in that:Including at least polyphenol compound and stannous
Ion gun, the pH of the composition is 5-8.
2. oral care composition according to claim 1, it is characterised in that:Composition has 5-7.5 pH value;It is preferred that
Ground, composition have 5-7 pH value;It is highly preferred that composition has 6-7 pH value.
3. according to any oral care composition in claim 1-2, it is characterised in that:Composition is further adjusted comprising pH
Save agent.
4. oral care composition according to claim 3, it is characterised in that:The pH adjusting agent includes sodium hydroxide, salt
Acid, sulfuric acid, citric acid and its salt, lactic acid and its salt, phosphoric acid and its salt, phthalic acid and its salt, pyrophosphoric acid and its salt, trimerization
One or more in phosphoric acid and its salt, polyphosphoric acids and its salt, citric acid and its salt, acetic acid and its salt.
5. oral care composition according to claim 1, it is characterised in that:The polyphenol compound includes following one
Kind or more than one compound:Epigallo-catechin gallate (EGCG), L-Epicatechin gallate, catechuic acid, table
Theine and epigallocatechin and chlorogenic acid.
6. oral care composition according to claim 5, it is characterised in that:The polyphenol compound is Tea Polyphenols.
7. oral care composition according to claim 1, it is characterised in that:It is sub- that the stannous ion source is selected from fluorination
Tin, stannous chloride, stannous pyrophosphate, phosphoric acid stannous chloride, stannous bromide, stannous iodide, stannous oxide, stannous sulfide, metaphosphoric acid are sub-
Tin, stannous acetate, stannous tartrate, stannous citrate, stannous malate, malonic acid stannous, gluconic acid stannous and oxalic acid are sub-
Tin is one or more kinds of.
8. oral care composition according to claim 1, it is characterised in that:The stannous ion source and Polyphenols chemical combination
The mass ratio of thing is more than 5:1;Preferably, the mass ratio of the stannous ion source and polyphenol compound is more than 10:1;More
Preferably, the mass ratio of the stannous ion source and polyphenol compound is more than 100:1.
9. according to oral care composition described in claim 1-8, it is characterised in that:The polyphenol compound is in oral care
Addition in composition is 0.0001-0.2wt%.
10. according to oral care composition described in right 1-8, it is characterised in that:The stannous ion source combines in oral care
Addition in thing is 0.001-1wt%.
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CN110236976A (en) * | 2019-06-06 | 2019-09-17 | 好维股份有限公司 | A kind of oral care composition comprising stablizing lysozyme |
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CN113384479A (en) * | 2020-03-13 | 2021-09-14 | 好维股份有限公司 | Oral care composition |
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