CN106798662B - A kind of oral care composition - Google Patents
A kind of oral care composition Download PDFInfo
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- CN106798662B CN106798662B CN201710045566.XA CN201710045566A CN106798662B CN 106798662 B CN106798662 B CN 106798662B CN 201710045566 A CN201710045566 A CN 201710045566A CN 106798662 B CN106798662 B CN 106798662B
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- oral care
- care composition
- stannous
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
- A61K2800/624—Coated by macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
- A61K2800/63—More than one coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/652—The particulate/core comprising organic material
Abstract
The invention discloses a kind of oral care compositions, belong to field of oral care, which includes: the polyphenol compound particle of package；With the acceptable carrier in oral cavity.Polyphenol compound is wrapped up using the form of embedding in oral care composition of the invention, its anti-oxidation function cannot be played because being oxidized easily well and be easy the problem of making oral care composition change colour by improving polyphenol compound in existing oral care composition.
Description
Technical field
The present invention relates to field of oral care.The polyphenol compound for including stabilization can be made to deposit more particularly, to a kind of
Oral care composition.
Background technique
Polyphenol compound such as tea polyphenols etc. are natural antioxidant, because it with good inoxidizability and shows
The ability of the removing free radical of work and be widely used in field of oral care.But polyphenol compound molecule contain it is multiple
Phenolic hydroxyl group is oxidized easily discoloration, and the raw material as oral care composition is in use, cannot effectively to play its original anti-
Oxidative function, and can also composition be changed colour.
For application of the polyphenol compound in oral care, it is found that oxygen content, pH value, temperature in existing research
Deng being all the factor for directly affecting its oxidation stain.Correspondingly, control oxygen content, is adjusted to suitable pH value range and adjusting
Temperature etc. appropriate can prevent its oxidation stain.Also by selection high-purity tea polypenols and control the clipped wire in raw material of toothpaste
Sub- content can also reduce it accordingly and aoxidize discoloration in extremely low range.But these above-mentioned methods are to oral care product
Preparation and material condition require stringent, while can also influence the other performance of product to a certain extent.
In view of the above problems, needing to provide a kind of new oral care composition, to improve polyphenol compound therein
It is oxidized easily, the problem that composition product is easy to change.
Summary of the invention
The purpose of the present invention is to provide a kind of oral care compositions, to solve polyphenol in existing oral care composition
Class compound cannot play its anti-oxidation function because being oxidized easily well and be easy the problem of making composition change colour.
In order to achieve the above objectives, the present invention provides a kind of oral care composition, which includes:
The polyphenol compound particle of package；With,
The acceptable carrier in oral cavity.
In the present invention, the polyphenol compound particle of the package refers to wrappage package polyphenol compound formation
Particle.According to the preferred embodiment of the present invention, the wrappage of the polyphenol compound particle of the package is selected from polylactic acid, jade
Rice starch, microcrystalline cellulose, polymethyl methacrylate, polyacrylate, fish glue, gum arabic, paraffin oil and glue two
The mixing of one or more of silica.Polyphenol compound is wrapped up, so that in polyphenol compound and composition
Other components etc. keep apart, the polyphenol compound included before use so as to a degree of improvement composition by oxygen
Change and composition problem easy to change.
More preferably embodiment, the wrappage of the polyphenol compound particle of the package are selected from fish according to the present invention
The mixing of one or more of glue, gum arabic, paraffin oil and silica colloidal.Researcher of the present invention was studying
It is found in journey, when being wrapped up using these types of wrappage polyphenol compound, to improvement polyphenol compound easily by oxygen
Change and composition better effect easy to change.It is highly preferred that the wrappage of the polyphenol compound particle of the package is paraffin
Oil.
The wrappage of specific embodiment according to the present invention, the polyphenol compound particle of the package forms at least one
Layer wrapping layer.
According to the preferred embodiment of the present invention, the wrappage of the polyphenol compound particle of the package forms at least two
Layer wrapping layer.The wrapping layer of multilayer enables polyphenol compound is more stable to be present in composition, and antioxidant effect is brighter
It is aobvious.
The wrappage of more preferable embodiment according to the present invention, the polyphenol compound particle of the package is formed two layers
Wrapping layer, i.e., the polyphenol compound particle of the described package includes kernel and outer wall.Preferably, the kernel packet of the wrapping layer
Wrap up in the mixture that object is paraffin oil and/or silica colloidal is formed.It is highly preferred that the kernel wrappage of the wrapping layer is stone
The mixture that wax oil and silica colloidal are formed with any proportion, for example, paraffin oil and the mass ratio of silica colloidal can
For 1:0.01~8,1:0.01~5,1:0.03~2,1:0.03~0.05 etc.；Preferably, the outer wall wrappage of the wrapping layer
For the mixture that fish glue and gum arabic are formed with any proportion, for example, the mass ratio of fish glue and gum arabic can for
Such as 0.1~8:0.1~8.With this condition, polyphenol compound compares using other package shapes in the composition obtained
Formula, with unexpected outstanding the most obvious and more preferably improve that the stability of polyphenol compound, to improve its anti-oxidant
Function and the effect for improving composition discoloration.
According to the preferred embodiment of the present invention, in the polyphenol compound particle of the package, polyphenol compound
Additive amount accounts for the 0.1ppm or more of oral care composition total amount.Polyphenols chemical combination within the scope of this additive amount, in composition
Object can preferably play its anti-oxidation function.Further, in certain more preferably specific embodiments of the invention, example
Such as, the additive amount of polyphenol compound accounts for the 1ppm or more of oral care composition total amount, it is highly preferred that polyphenol compound
Additive amount accounts for the 0.001%~3% of oral care composition total amount；Most preferably, the additive amount of polyphenol compound accounts for oral cavity
The 0.01%~2% of care composition total amount.Further, the additive amount of polyphenol compound can also be to account for oral care combination
Object total amount such as 0.05%~2%, 0.1%~1.5%.
According to the preferred embodiment of the present invention, by mass percentage, the polyphenol compound particle of the package
Additive amount account for oral care composition total amount 0.01~~5%；Further, in certain specific embodiments of the invention
In, for example, package polyphenol compound ion additive amount account for oral care composition total amount 0.2%~1.5%,
0.2%~1.2%, 0.2%~1%, 0.3%~1%, 0.3%~0.6%, 0.5%~1% etc..It is highly preferred that the packet
The additive amount for the polyphenol compound particle wrapped up in accounts for the 0.1%~1.5% of oral care composition total amount, more preferably 0.1%
~0.7%, most preferably 0.2%~0.5%.
Specific embodiment according to the present invention, the polyphenol compound include one of following compound or more
Kind: Epigallo-catechin gallate (EGCG) (EGCg), L-Epicatechin gallate (ECG), catechuic acid (Catechin), table
Catechin (Epicatechin, EC), epigallocatechin (EGC) and chlorogenic acid.
According to the preferred embodiment of the present invention, the polyphenol compound is tea polyphenols.
According to the preferred embodiment of the present invention, by mass percentage, in the polyphenol compound particle of the package,
The mass ratio of lapping and polyphenol compound is 1:1~20:1, preferably 5:1~10:1.
Unless otherwise stated, the percentage of the repertoire mentioned in the present invention presses the weight of total composition
It calculates.Unless otherwise stated, " ppm " (parts per million) mentioned in the present invention refers to the ppm calculated by weight.
According to the preferred embodiment of the present invention, the particle size of the polyphenol compound particle of the package be 50~
1600 microns.Further, in certain specific embodiments of the invention, the polyphenol compound particle of the package is put down
Equal partial size is between 150~250 microns.
It according to the preferred embodiment of the present invention, by mass percentage, also include water in the oral care composition
Dissolubility stannous ion source.In the present invention, in the composition of the polyphenol compound particle containing package, above-mentioned content is added
Water-soluble stannous ion source helps to improve the anti-oxidant of polyphenol compound and improves the metachromatism of composition.Preferably,
The water solubility stannous ion source accounts for the 0.05%~2% of oral care composition weight.Preferably 0.05%~2%.Into one
Step ground, in certain specific embodiments of the invention, for example, the content of water-soluble stannous ion source can for 0.05%~
1.6%, 0.08%~1.5% or 1%~1.5% etc..
According to the preferred embodiment of the present invention, the water-soluble stannous ion source may include stannous fluoride, stannous chloride,
Stannous pyrophosphate, phosphoric acid stannous chloride, stannous bromide, stannous iodide, stannous oxide, stannous sulfide, metaphosphoric acid stannous, stannous acetate,
One of stannous tartrate, stannous citrate, stannous malate, malonic acid stannous, gluconic acid stannous and stannous oxalate or
It is several.It is highly preferred that the water solubility stannous ion source is selected from stannous fluoride.
According to the preferred embodiment of the present invention, the mass ratio of the water-soluble stannous ion source and polyphenol compound exists
1:1 or more；It is highly preferred that the mass ratio of the water solubility stannous ion source and polyphenol compound is greater than 1.5:1, it is greater than
5:1 is greater than 10:1.
Oral care composition in the present invention, which refers in general use process, deliberately to be swallowed for specific
The absorbability of therapeutic agent is administered, but retains the sufficiently long time in the oral cavity, with substantially contact all dental surface and/
Or oral cavity tissue is to obtain the product of orally active.The oral care composition can be various forms, including toothpaste, tooth
Powder, gutta-percha, gums glue, mouthwash, foam, mousse, artificial tooth product, mouth spraying agent, pastille, chewable tablets or chewing gum.Oral cavity shield
Reason composition can be also incorporated on band or film, directly to apply or adhere to oral surfaces.
" the acceptable carrier in oral cavity " for including in oral care composition of the invention is referred to as oral care
The ingredient of composition suitable for the physiological environment in oral cavity, and does not lead to the excessive carrier that side effect is generated to oral cavity.For example,
The acceptable carrier in oral cavity also may include suitable beauty and/or treatment or functional active substances.
Further, a variety of acceptable carriers in oral cavity well known in the art are suitable for oral care combination of the invention
In object.For example, the carrier that the department of stomatology receives includes but is not limited to moisturizer, abrasive, thickener, surfactant, tune
One of taste agent, appearance investigation agent, water are a variety of.Wherein:
Moisturizer is that oral care composition is prevented to be dehydrated the ingredient being hardened.For example, moisturizer may include but be not limited to as
Sorbierite, propylene glycol, glycerol, polyethylene glycol of low molecular weight etc..By mass percentage, moisturizer is in oral care composition
In content be usually 10%~80%, preferably 50%~80%.
Abrasive is the main component that cleaning action is played in oral care composition, and the selection of abrasive should consider it comprehensively
Hardness, size and content etc., it is ensured that tooth is not worn while effectively cleaning, for example, abrasive may include: calcium carbonate, phosphoric acid
Hydrogen calcium, calcium pyrophosphate, tricalcium phosphate, silica, alumina silicate, aluminium hydroxide, aluminium oxide, zeolite, titanium oxide, silicic acid, kaolinite
Soil etc..By mass percentage, weight ratio of the abrasive in oral care composition is usually 0~50%.
Thickener is a kind of viscosity for increasing solution or liquid/solid mixtures, but will not substantially change its property
Substance.The purpose that thickener is added is to provide skeleton, mobility and stability to product.For example, thickener includes but not
It is limited to below one or more: hydroxyethyl cellulose, carboxymethyl cellulose and its salt (e.g., sodium carboxymethylcellulose CMCNa),
Carrageenan (Carrageenan), carboxyl vinyl polymer, xanthan gum (Xanthan gum), carragheen, gelatin, branch
Starch, sodium alginate, card pool nurse etc..In some embodiments, the thickener includes that xanthan gum, carragheen or carboxymethyl are fine
Tie up one of plain sodium or a variety of.By mass percentage, content of the thickener in oral care composition be usually 0~
70%.
Surfactant can play the role of emulsifying essence and blistering in oral care composition.For example, surface-active
Agent includes but is not limited to below one or more: anionic surfactant is (for example, dodecyl sodium sulfate, dodecyl
Sodium sulphate SLS etc.), amphoteric surfactant (for example, glycine betaine), amino acid surfactant (for example, laurel soda ash acid sodium),
Or nonionic surfactant (for example, polyoxyethylene and poiyoxypropylene copolymer, polyethylene glycol etc.).By mass percentage,
Weight ratio of the surfactant in oral care composition is usually 0.1~4%.
Flavoring agent refers to the substance for improving oral care composition organoleptic properties.For example, flavoring agent includes but unlimited
In: saccharin sodium, flavored oils' (e.g., oleum menthae viridis, oleum menthae piperitae, wintergreen, sassafras oil, caryophyllus oil, Yang Su careless oil, eucalyptus oil, cortex cinnamomi
Oil, lemon oil and orange oil), essence, gaultherolin or eugenol.By mass percentage, flavoring agent is in oral care group
The weight ratio closed in object is usually 0.05~2%.
Appearance investigation agent can improve the mode of appearance of composition.Suitable appearance investigation agent may include mica, titanium dioxide
Deng.Weight ratio in oral care composition is usually 0.05~5%.
In some embodiments, oral care composition of the invention further also containing it is one or more activity at
Point." active constituent " is the ingredient for referring to treat or alleviate oral conditions or disease.In some specific embodiments, described
Active constituent includes one of anti-caries agent, anti-sensitizer, antibacterial agent, antilithic, whitening agent or a variety of.Wherein:
Anti-caries agent refers to the substance for having inhibiting effect to dental caries, such as can be by reducing the molten of enamel hydroxyapatite
Xie Du enhances the substance of the anti-caries ability of tooth, or control bacterial plaque, the substance for inhibiting bacterial growth.For example, anti-caries agent include but
It is not limited to, fluoride ion source (e.g., sodium fluoride, potassium fluoride, calcirm-fluoride, magnesium fluoride, ammonium fluoride, sodium monofluorophosphate, single fluorophosphoric acid
Potassium, fluosilicate etc.), phosphorus reagent (calcium phosphate, sodium trimetaphosphate, magnesium glycerophosphate, calcium lactophosphate, casein sodium etc.),
Or arginine and its derivative.Preferably, in some specific embodiments, the anti-caries agent includes fluoride ion source.
Anti-sensitizer refers to through inhibition nerve impulse or can close dentinal tubule or reduce its permeability, to prevent
Or the substance for the treatment of dental hypersensitiveness.For example, anti-sensitizer includes but is not limited to: dipotassium glycyrrhizinate, potassium fluoride, potassium nitrate, chlorine
Change the potassium ion sources such as potassium.Preferably, in some specific embodiments, the anti-sensitizer includes potassium ion source.
Antibacterial agent is to refer to make within a certain period of time the growth of certain micro-organisms in oral care composition or breeding to protect
It holds in necessary chemical substance below horizontal.Exemplary antibacterial agent includes but is not limited to: zinc oxide, stannous chloride, tetrahydro turmeric
Element, cetylpyridinium chloride, triclosan etc..
Antilithic refers to the metal ion complex that can play the role of anti-tooth calculus.For example, antilithic includes
But it is not limited to: pyrophosphate, tripolyphosphate, hexametaphosphate or citrate.
Whitening agent refers to the substance that whitening function can be played to tooth.For example, whitening agent includes but is not limited to: peroxide
Bleaching agent, papain, glucose oxidase.
The preparation method of oral care composition of the invention is to adopt with method known in this field, can be by reference to existing
Technology carries out.Preparation method includes mixing the polyphenol compound particle of package with the acceptable carrier in oral cavity and being obtained
.
The embedding means that this field routine can be used in the polyphenol compound particle of package in the present invention obtain.
Unless otherwise specified, the raw material in the present invention can pass through the commercially available conventional method being commercially available or pass through this field
It obtains.
In addition, unless otherwise specified, any range documented by the present invention includes any number between end value and end value
Any subrange that any number between value and end value or end value is constituted.
Beneficial effects of the present invention are as follows:
By wrapping up the polyphenol compound in oral care composition in the present invention, the Polyphenols of package is formed
Compound particles, at a temperature of improving room temperature and high temperature (50 DEG C), the stability of polyphenol compound in composition is improved existing
In some oral care compositions polyphenol compound cannot be played well because being oxidized easily its anti-oxidation function and
It is easy the problem of making oral care composition change colour.
It is further advanced by the specific wrappage of selection and package form in the present invention, further greatly improves more
Phenolic compound is the problem of the antioxidation and prevention and treatment composition of room temperature and high temperature (50 DEG C) change colour.
Specific embodiment
In order to illustrate more clearly of the present invention, below with reference to preferred embodiment, the present invention is described further.Ability
Field technique personnel should be appreciated that following specifically described content is illustrative and be not restrictive, this should not be limited with this
The protection scope of invention.
Embodiment 1
One, a kind of oral care composition lotion product, formula are as shown in table 1 below.
Two, the preparation method of above-mentioned oral care composition such as includes the following steps:
Routinely other raw materials in formula in addition to the polyphenol particle 1 of package are configured to cream by the preparation of lotion of toothpaste matrix
Body matrix；Particle 1 (the tea polyphenols particle of polylactic acid package), the oral care composition lotion for stirring evenly of the invention is added
Product.
Embodiment 2~8
The formula difference of the oral care composition lotion product of embodiment 2~8 is as shown in table 1 below, and preparation method is the same as real
Example 1 is applied, difference is, embodiment 2 and 6 changes the particle 1 in embodiment 1 into particle 2；Embodiment 3 and 7 will be in embodiment 1
Particle 1 changes particle 3 into；Embodiment 4 and 8 changes the particle 1 in embodiment 1 into particle 4.
Comparative example 1~2
The formula difference of the oral care composition of comparative example 1~2 is as shown in table 1 below, and the preparation method is the same as that of Example 1.Area
It is not, the particle 1 in embodiment 1 is changed into the tea polyphenols powder of equal partial sizes by comparative example 1 and 2 respectively.
Formula (Examples 1 to 8 and the comparison of 1 embodiment of the present invention of table and comparative example oral care composition lotion product
Example 1~2)
In above-mentioned table 1, the particle 1~4 in Examples 1 to 8 formula is referred respectively to:
Particle 1: the tea polyphenols particle of polylactic acid package, particle diameter are 355~600 microns；
Particle 2: the tea polyphenols particle of the mixing package of cornstarch and microcrystalline cellulose and PMMA, particle diameter 355
~600 microns, wherein the mass ratio of cornstarch, microcrystalline cellulose and PMMA are as follows: 1:0.5~8:0.5~2；
Particle 3: the tea polyphenols particle of polyacrylate package, particle diameter are 355~600 microns；
Particle 4: for the tea polyphenols particle of two layers of wrapping layer package, particle diameter is 355~600 microns, wherein kernel packet
Wrapping up in material is paraffin oil, and outer wall lapping is the mixture of fish glue and gum arabic.Paraffin oil, fish glue, gum arabic
Mass ratio are as follows: 1:0.1~8:0.1~8.
The tea polyphenols particle that above-mentioned particle 1~4 wraps up is prepared by conventional embedding method.
In the formula of each embodiment of above-mentioned table 1 and comparative example, the content of tea polyphenols is the 167ppm of total raw material additive amount.
The Anti-tarnish property of the test resulting composition lotion product of experimental example 1
Test method: Example 1~8 and 1~2 gained lotion product of comparative example respectively are transferred in 50 DEG C of temperature
(i.e. aging) 1 month is set, with color difference meter, for example, U.S. X-Riet color difference meter (SP64) measures each embodiment and comparative example respectively
L*a*b value before and after the lotion aging of product, L*a*b system provide the numerical expression of three-dimensional color space, and wherein L* can be used for cream
The measurement of body whiteness, L value is bigger, represents that lotion color is whiter, and L value is smaller, and it is darker to represent lotion color.The variation of L value is bigger,
Lotion color change is bigger.The difference of color is indicated with △ L value before and after the lotion aging of product, as a result as shown in table 2 below.
The color difference of lotion product before and after 2 aging of table
| Product | The difference △ L of color before and after the aging of product |
| Embodiment 1 | -3.21 |
| Embodiment 2 | -2.94 |
| Embodiment 3 | -3.99 |
| Embodiment 4 | -1.35 |
| Comparative example 1 | -4.25 |
| Embodiment 5 | -2.1 |
| Embodiment 6 | -1.99 |
| Embodiment 7 | -1.95 |
| Embodiment 8 | -0.98 |
| Comparative example 2 | -2.93 |
After in upper table 2 it is found that tea polyphenols particle is wrapped up, it is variable preferably to improve oral care lotion product
The problem of color；It uses two layers of package and kernel wrappage is paraffin oil and/or the mixture of silica colloidal, outer wall wrappage
When for the mixture of fish glue and gum arabic, to improving product discoloration problem better effect；In addition, the suitable fluorination of addition is sub-
It is also more obvious to the improvement of product discoloration problem after tin.
Experimental example 2 studies the antioxygenic property of tea polyphenols in lotion product
Test philosophy: since tea polyphenols are mixtures, be added into formula in after, can not further detect its content or whether
It is oxidized.EGCg is the main active of tea polyphenols, substantially accounts for the 60% of tea polyphenols total amount, the content of EGCg can lead in formula
The method for crossing HPLC detects to obtain.It therefore, can be by the situation of change of EGCg content in measurement product, thus to determine in product
Tea polyphenols antioxygenic property.
Test method: the lotion product that HPLC detection method measurement embodiment 5~8 and comparative example 2 is respectively adopted exists respectively
1 month (1M), 2 months (2M) and after 3 months (3M) are placed at a temperature of room temperature (25 DEG C or so), 40 DEG C of temperature and 50 DEG C, are produced
The content of EGCg in product, as a result as shown in table 3 below, the content of EGCg is to account for the content of products material total addition level in table 3.
The content of EGCg in lotion product after different time is placed under 3 different temperatures of table
From in upper table 3 it is found that the product of the embodiment of the present invention is in room temperature and to saving 3 months under 50 DEG C of hot conditions
When above, the EGCg in product is kept at very high content, this also illustrates, the tea polyphenols in product still maintain high-content
Level, the anti-oxidation function that the tea polyphenol stability after package improves, and had；Use two layers package and kernel wrappage for
The mixture of paraffin oil and/or silica colloidal, when outer wall wrappage is the mixture of fish glue and gum arabic, aforementioned effect
Fruit is more preferably.
Embodiment 9~12
The formula difference of the oral care composition lotion product of embodiment 9~12 is as shown in table 4 below, and preparation method is the same as real
Example 1 is applied, difference is, the particle in embodiment 9~12 is respectively particle a~particle d.
Comparative example 3
The formula of the oral care composition lotion product of comparative example 3 distinguishes as shown in table 4 below, the same embodiment of preparation method
1, difference is, the particle in embodiment 9~12 is tea polyphenols powder.
Formula (embodiment 9~12 and the comparison of 4 embodiment of the present invention of table and comparative example oral care composition lotion product
Example 3)
In above-mentioned table 4, particle a~particle b in the formula of embodiment 9~12 is referred respectively to:
Particle a: wrapping layer is single layer, the tea polyphenols particle of paraffin oil package；
Particle b: wrapping layer is single layer, the tea polyphenols particle of the mixture package of paraffin oil and silica colloidal, wherein
The mass ratio of paraffin oil and silica colloidal are as follows: 30:1~20:1；
Particle c: two layers of wrapping layer, kernel paraffin oil, outer wall is the tea of the mixture package of fish glue and gum arabic
Polyphenol particle, wherein the mass ratio of paraffin oil, fish glue and gum arabic is 1:0.1~8:0.1~8；
Particle d: two layers of wrapping layer, the mixture of kernel paraffin oil and silica colloidal, outer wall is fish glue and I
The tea polyphenols particle of the mixture package of uncle's natural gum, wherein paraffin oil, silica colloidal, the matter of fish glue and gum arabic
Amount is than being 1:0.03~0.05:0.1~8:0.1~8；
The tea polyphenols particle of above-mentioned particle a~d package is prepared by conventional embedding method, every kind of particle
Partial size in 50~1600 microns, average grain diameter is 300 microns.
In the formula of each embodiment of above-mentioned table 4 and comparative example, the content of tea polyphenols is total raw material additive amount
0.1wt%.
Using the inoxidizability of tea polyphenols in 3 product of technique study embodiment 9~12 and comparative example of above-mentioned experimental example 2
Can, as a result as shown in table 5 below.As can be known from Table 5, compare the wrapping layer of single layer, when the wrapping layer of tea polyphenols particle is two layers
When, the anti-oxidation function of tea polyphenols is more preferable；The kernel wrappage that compares is only paraffin oil, and outer wall wrappage is fish glue and Arab
The mixing of natural gum, and the package tea polyphenols particle formed, when use two layers of package and kernel wrappage is paraffin oil and gluey two
The mixture of silica when outer wall wrappage is the mixture of fish glue and gum arabic, resists to tea polyphenols in product are improved
Oxidative function effect is more significant.
The content of EGCg in lotion product after different time is placed under 5 different temperatures of table
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention may be used also on the basis of the above description for those of ordinary skill in the art
To make other variations or changes in different ways, all embodiments can not be exhaustive here, it is all to belong to this hair
The obvious changes or variations that bright technical solution is extended out are still in the scope of protection of the present invention.
Claims (13)
1. a kind of oral care composition, which is characterized in that the oral care composition includes:
The polyphenol compound particle of package；With,
The acceptable carrier in oral cavity；
The polyphenol compound particle of the package includes kernel and outer wall；The kernel lapping is paraffin oil and/or glue
The mixture of shape silica；The outer wall lapping is the mixture of fish glue and gum arabic；
In the polyphenol compound particle of the package, the additive amount of polyphenol compound accounts for oral care composition total amount
0.001%~3%。
2. oral care composition according to claim 1, which is characterized in that the polyphenol compound particle of the package
In, the additive amount of polyphenol compound accounts for the 0.01% ~ 2% of oral care composition total amount.
3. oral care composition according to claim 1, which is characterized in that by mass percentage, the package
The additional amount of polyphenol compound particle is the 0.01% ~ 5% of oral care composition total amount.
4. oral care composition according to claim 3, which is characterized in that by mass percentage, the package
The additional amount of polyphenol compound particle is the 0.1% ~ 1.5% of oral care composition total amount.
5. oral care composition according to claim 1, which is characterized in that by mass percentage, the package
The additional amount of polyphenol compound particle is the 0.1% ~ 0.7% of oral care composition total amount.
6. oral care composition according to claim 1, which is characterized in that by mass percentage, the package
The additional amount of polyphenol compound particle is the 0.2% ~ 0.5% of oral care composition total amount.
7. described in any item oral care compositions according to claim 1 ~ 6, which is characterized in that the polyphenol compound packet
Containing one of following compound or a variety of: Epigallo-catechin gallate (EGCG), L-Epicatechin gallate, catechu
Acid, epicatechin, epigallocatechin and chlorogenic acid.
8. described in any item oral care compositions according to claim 1 ~ 6, which is characterized in that the polyphenol compound is
Tea polyphenols.
9. described in any item oral care compositions according to claim 1 ~ 6, which is characterized in that by mass percentage, institute
It states in oral care composition also comprising water-soluble stannous ion source.
10. oral care composition according to claim 9, which is characterized in that the water solubility stannous ion source is selected from
Stannous fluoride, stannous chloride, stannous pyrophosphate, phosphoric acid stannous chloride, stannous bromide, stannous iodide, stannous oxide, stannous sulfide, partially
Phosphoric acid stannous chloride, stannous acetate, stannous tartrate, stannous citrate, stannous malate, malonic acid stannous, gluconic acid stannous and
One or more of stannous oxalate.
11. oral care composition according to claim 10, which is characterized in that the wherein water-soluble stannous ion source
It is greater than 1.5:1 with the mass ratio of polyphenol compound.
12. oral care composition according to claim 11, which is characterized in that the wherein water-soluble stannous ion source
Account for the 0.001% ~ 5% of oral care composition weight.
13. oral care composition according to claim 12, which is characterized in that the wherein water-soluble stannous ion source
Account for the 0.05 ~ 2% of oral care composition weight.
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|---|---|---|---|---|
| CN103110107A (en) * | 2013-01-20 | 2013-05-22 | 浙江大学 | Method for wrapping tea polyphenol by using protein gel |
| CN103571496A (en) * | 2012-07-18 | 2014-02-12 | 华东理工大学 | Chitosan microsphere with high oxidation resistance and its preparation method |
| CN104223078A (en) * | 2014-09-26 | 2014-12-24 | 天津市聚星康华医药科技有限公司 | Tea polyphenol oral cavity instant film and preparation method thereof |
| CN106074192A (en) * | 2016-07-01 | 2016-11-09 | 好来化工(中山)有限公司 | Antioxidative oral care composition |
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|---|---|---|---|---|
| CN103571496A (en) * | 2012-07-18 | 2014-02-12 | 华东理工大学 | Chitosan microsphere with high oxidation resistance and its preparation method |
| CN103110107A (en) * | 2013-01-20 | 2013-05-22 | 浙江大学 | Method for wrapping tea polyphenol by using protein gel |
| CN104223078A (en) * | 2014-09-26 | 2014-12-24 | 天津市聚星康华医药科技有限公司 | Tea polyphenol oral cavity instant film and preparation method thereof |
| CN106074192A (en) * | 2016-07-01 | 2016-11-09 | 好来化工(中山)有限公司 | Antioxidative oral care composition |
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