CN106798662A - A kind of oral care composition - Google Patents
A kind of oral care composition Download PDFInfo
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- CN106798662A CN106798662A CN201710045566.XA CN201710045566A CN106798662A CN 106798662 A CN106798662 A CN 106798662A CN 201710045566 A CN201710045566 A CN 201710045566A CN 106798662 A CN106798662 A CN 106798662A
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- oral care
- care composition
- stannous
- polyphenol compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
- A61K2800/624—Coated by macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
- A61K2800/63—More than one coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/652—The particulate/core comprising organic material
Abstract
The invention discloses a kind of oral care composition, belong to field of oral care, the oral care composition is included：The polyphenol compound particle of parcel；With oral cavity acceptable carrier.Polyphenol compound is wrapped up in the form of embedding in oral care composition of the invention, polyphenol compound can not well play its anti-oxidation function because being oxidized easily and easily make the problem of oral care composition discoloration in improving existing oral care composition.
Description
Technical field
The present invention relates to field of oral care.Can deposit the polyphenol compound for including stabilization more particularly, to a kind of
Oral care composition.
Background technology
Polyphenol compound such as Tea Polyphenols etc. is natural polyphenoils, because it has good inoxidizability and shows
The ability of the removing free radical of work and be widely used in field of oral care.But polyphenol compound molecule contains multiple
Phenolic hydroxyl group, is oxidized easily discoloration, when being used as the raw material of oral care composition, it is impossible to effectively play its original anti-
Oxidative function, and can also cause that composition changes colour.
Application for polyphenol compound in MC, understands, oxygen content, pH value, temperature in existing research
Deng being all the factor that directly affects its oxidation stain.Accordingly, oxygen content, regulation to suitable pH value range and regulation are controlled
Temperature etc. can be appropriate prevent its oxidation stain.Also by the clipped wire in selection high-purity tea polypenols and control raw material of toothpaste
Sub- content is in extremely low scope, it is also possible to reduce its oxidation discoloration accordingly.But above-mentioned these methods are to oral care product
Preparation and material condition requirement it is strict, while can also to a certain extent influence the other performance of product.
For problem above, it is desirable to provide a kind of new oral care composition, to improve polyphenol compound therein
Be oxidized easily, the problem that composition product is easy to change.
The content of the invention
It is an object of the invention to provide a kind of oral care composition, to solve polyphenol in existing oral care composition
The problem that class compound can not well play its anti-oxidation function because being oxidized easily and easily make composition change colour.
To reach above-mentioned purpose, the present invention provides a kind of oral care composition, and the oral care composition is included：
The polyphenol compound particle of parcel；With,
Oral cavity acceptable carrier.
In the present invention, the polyphenol compound particle of the parcel refers to wrap up what polyphenol compound was formed with wrappage
Particle.Preferred embodiment of the invention, the wrappage of the polyphenol compound particle of the parcel is selected from PLA, jade
Rice starch, microcrystalline cellulose, polymethyl methacrylate, polyacrylate, fish glue, gum arabic, paraffin oil and gluey two
The mixing of one or more in silica.Polyphenol compound is wrapped up so that in polyphenol compound and composition
Other components etc. keep apart so that can a certain degree of improvement composition using the polyphenol compound for preceding including by oxygen
Change and composition problem easy to change.
According to the present invention more preferably implementation method, the wrappage of the polyphenol compound particle of the parcel is selected from fish
The mixing of one or more in glue, gum arabic, paraffin oil and silica colloidal.Researcher of the present invention was studying
Found in journey, when being wrapped up polyphenol compound using this several wrappage, to improving polyphenol compound easily by oxygen
Change and easy to change better of composition.It is highly preferred that the wrappage of the polyphenol compound particle of the parcel is paraffin
Oil.
Specific embodiment of the invention, the wrappage of the polyphenol compound particle of the parcel forms at least one
Layer integument.
Preferred embodiment of the invention, the wrappage of the polyphenol compound particle of the parcel forms at least two
Layer integument.The integument of multilayer enables that polyphenol compound is more stable and is present in composition that antioxidant effect is brighter
It is aobvious.
More preferably implementation method of the invention, the wrappage of the polyphenol compound particle of the parcel forms two-layer
Integument, i.e., the polyphenol compound particle of described parcel includes kernel and outer wall.Preferably, the kernel bag of the integument
Wrap up in the mixture that thing is formed for paraffin oil and/or silica colloidal.It is highly preferred that the kernel wrappage of the integument is stone
The mixture that wax oil and silica colloidal are formed with any proportioning, for example, the mass ratio of paraffin oil and silica colloidal can
It is 1:0.01~8,1:0.01~5,1:0.03~2,1:0.03~0.05 etc.；Preferably, the outer wall wrappage of the integument
Be mixture that fish glue and gum arabic are formed with any proportioning, for example, the mass ratio of fish glue and gum arabic can as a example by
Such as 0.1~8:0.1~8 etc..With this understanding, polyphenol compound compares using other parcel shapes in the composition for obtaining
Formula, with unexpected protrusion the most substantially and more preferably improve the stability of polyphenol compound, to improve its anti-oxidant
Function and the effect of improvement composition discoloration.
Preferred embodiment of the invention, in the polyphenol compound particle of the parcel, polyphenol compound
Addition accounts for more than the 0.1ppm of oral care composition total amount.In the range of this addition, the Polyphenols chemical combination in composition
Thing can preferably play its anti-oxidation function.Further, it is of the invention some more preferably in specific embodiment, example
Such as, the addition of polyphenol compound accounts for more than the 1ppm of oral care composition total amount, it is highly preferred that polyphenol compound
Addition accounts for the 0.001%~3% of oral care composition total amount；Most preferably, the addition of polyphenol compound accounts for oral cavity
The 0.01%~2% of care composition total amount.Further, the addition of polyphenol compound can also be to account for MC combination
Such as 0.05%~2%, 0.1%~1.5% etc. of thing total amount.
Preferred embodiment of the invention, by mass percentage, the polyphenol compound particle of the parcel
Addition account for oral care composition total amount 0.01~~5%；Further, in some specific embodiments of the invention
In, for example, parcel polyphenol compound ion addition account for oral care composition total amount 0.2%~1.5%,
0.2%~1.2%, 0.2%~1%, 0.3%~1%, 0.3%~0.6%, 0.5%~1% etc..It is highly preferred that the bag
The addition of the polyphenol compound particle wrapped up in accounts for the 0.1%~1.5% of oral care composition total amount, more preferably 0.1%
~0.7%, most preferably 0.2%~0.5%.
Specific embodiment of the invention, the polyphenol compound includes the one kind or many in following compound
Kind：Epigallo-catechin gallate (EGCG) (EGCg), L-Epicatechin gallate (ECG), catechuic acid (Catechin), table
Catechin (Epicatechin, EC), epigallocatechin (EGC) and chlorogenic acid.
Preferred embodiment of the invention, the polyphenol compound is Tea Polyphenols.
Preferred embodiment of the invention, by mass percentage, in the polyphenol compound particle of the parcel,
Lapping is 1 with the mass ratio of polyphenol compound:1~20:1, preferably 5:1~10:1.
Unless otherwise stated, the percentage of the repertoire mentioned in the present invention presses the weight of total composition
Calculate.Unless otherwise stated, " ppm " (PPM) mentioned in the present invention refers to the ppm for calculating by weight.
Preferred embodiment of the invention, the particle size of the polyphenol compound particle of the parcel for 50~
1600 microns.Further, in certain specific embodiments of the invention, the polyphenol compound particle of the parcel it is flat
Equal particle diameter is between 150~250 microns.
Preferred embodiment of the invention, by mass percentage, also includes water in the oral care composition
Dissolubility stannous ion source.In the present invention, in the composition of the polyphenol compound particle containing parcel, above-mentioned content is added
Water-soluble stannous ion source helps to improve the anti-oxidant of polyphenol compound and improves the metachromatism of composition.Preferably,
The water-soluble stannous ion source accounts for the 0.05%~2% of oral care composition weight.Preferably 0.05%~2%.Enter one
Step ground, in some specific embodiments of the invention, for example, the content of water-soluble stannous ion source can for 0.05%~
1.6%th, 0.08%~1.5% or 1%~1.5% etc..
Preferred embodiment of the invention, the water-soluble stannous ion source may include stannous fluoride, stannous chloride,
Stannous pyrophosphate, phosphoric acid stannous chloride, stannous bromide, stannous iodide, stannous oxide, stannous sulfide, metaphosphoric acid stannous, stannous acetate,
One kind in stannous tartrate, stannous citrate, stannous malate, malonic acid stannous, gluconic acid stannous and stannous oxalate or
It is several.It is highly preferred that the water-soluble stannous ion source is selected from stannous fluoride.
Preferred embodiment of the invention, the water-soluble stannous ion source exists with the mass ratio of polyphenol compound
1:More than 1；It is highly preferred that the water-soluble stannous ion source is more than 1.5 with the mass ratio of polyphenol compound:1, it is greater than
5:1, more than 10:1.
It is not deliberately to be swallowed for specific during generally using that oral care composition in the present invention refers to
The absorbability administration of therapeutic agent, but retains the sufficiently long time in the oral cavity, with substantially contact all of dental surface and/
Or oral cavity tissue is obtaining the product of orally active.The oral care composition can be various forms, including toothpaste, tooth
Powder, gutta-percha, gums glue, mouthwash, foam, mousse, artificial tooth product, mouth spraying agent, lozenge, chewable tablets or chewing gum.The oral cavity is protected
Reason composition can be also incorporated on band or film, directly to apply or adhere to oral surfaces.
" the oral cavity acceptable carrier " included in oral care composition of the invention is referred to as MC
The composition of composition, it is adaptable to the physiological environment in oral cavity, and do not cause the excessive carrier that side effect is produced to oral cavity.For example,
The oral cavity acceptable carrier can also include suitable beauty and/or treatment or functional active substances.
Further, various oral cavity acceptable carriers well known in the art are suitable for MC combination of the invention
In thing.For example, the carrier that the department of stomatology receives is included but is not limited to, NMF, abrasive, thickener, surfactant, tune
One or more in taste agent, appearance investigation agent, water.Wherein：
NMF is to prevent oral care composition to be dehydrated the composition being hardened.For example, NMF may include but be not limited to as
Sorbierite, propane diols, glycerine, polyethylene glycol of low-molecular-weight etc..By mass percentage, NMF is in oral care composition
In content be usually 10%~80%, preferably 50%~80%.
Abrasive is the main component that cleaning action is played in oral care composition, and the selection of abrasive should comprehensively consider it
Hardness, size and content etc., it is ensured that do not wear and tear tooth while effectively cleaning, for example, abrasive can be included：Calcium carbonate, phosphoric acid
Hydrogen calcium, calcium pyrophosphate, tricalcium phosphate, silica, alumina silicate, aluminium hydroxide, aluminum oxide, zeolite, titanium oxide, silicic acid, kaolinite
Soil etc..By mass percentage, part by weight of the abrasive in oral care composition is usually 0~50%.
Thickener is the viscosity of a kind of increase solution or liquid/solid mixtures, but will not substantially change its property
Material.The purpose for adding thickener is to provide skeleton, mobility and stability to product.For example, thickener include but not
It is limited to following one or more：Hydroxyethyl cellulose, carboxymethylcellulose calcium and its salt (e.g., sodium carboxymethylcellulose CMCNa),
Carrageenan (Carrageenan), carboxyl vinyl polymer, xanthans (Xanthan gum), carragheen, gelatin, side chain
Starch, sodium alginate, card pool nurse etc..In some embodiments, the thickener includes that xanthans, carragheen or carboxymethyl are fine
One or more in the plain sodium of dimension.By mass percentage, content of the thickener in oral care composition be usually 0~
70%.
Surfactant can play a part of emulsifying essence and foaming in oral care composition.For example, surface-active
Agent includes but is not limited to following one or more：Anion surfactant is (for example, dodecyl sodium sulfate, dodecyl
Sodium sulphate SLS etc.), amphoteric surfactant (for example, glycine betaine), amino acid surfactant (for example, bay soda ash acid sodium),
Or nonionic surfactant (for example, polyoxyethylene and poiyoxypropylene copolymer, polyethylene glycol etc.).By mass percentage,
Part by weight of the surfactant in oral care composition is usually 0.1~4%.
Flavor enhancement refers to the material for improving oral care composition organoleptic properties.For example, flavor enhancement includes but does not limit
In：Saccharin sodium, flavored oils (e.g., oleum menthae viridis, oleum menthae piperitae, wintergreen, sassafras oil, caryophyllus oil, Yang Su grass oil, volatile oil extracted from eucalyptus' leaves or twigs, Chinese cassia tree
Oil, lemon oil and orange oil), essence, gaultherolin or eugenol.By mass percentage, flavor enhancement is in MC group
Weight in compound is than usually 0.05~2%.
Appearance investigation agent can improve the mode of appearance of composition.Suitable appearance investigation agent can include mica, titanium dioxide
Deng.Weight in oral care composition is than usually 0.05~5%.
In some embodiments, oral care composition of the invention further also containing one or more activity into
Point." active component " is the composition for referring to treat or alleviate oral conditions or disease.It is described in some specific embodiments
Active component includes one or more in anti-caries agent, anti-sensitizer, antiseptic, antilithic, whitening agent.Wherein：
Anti-caries agent refers to the material for having inhibitory action to dental caries, for example can be by reducing the molten of enamel hydroxyapatite
The material of the anti-caries ability of Xie Du enhancing teeth, or control bacterial plaque, the material of bacteria growing inhibiting.For example, anti-caries agent include but
It is not limited to, fluoride ion source (e.g., sodium fluoride, potassium fluoride, calcirm-fluoride, magnesium fluoride, ammonium fluoride, sodium monofluorophosphate, single fluorophosphoric acid
Potassium, fluosilicate etc.), phosphorus reagent (calcium phosphate, sodium trimetaphosphate, magnesium glycerophosphate, calcium lactophosphate, casein sodium etc.),
Or arginine and its derivative.Preferably, in some specific embodiments, the anti-caries agent includes fluoride ion source.
Anti-sensitizer refers to by suppressing nerve impulse or can close dentinal tubule or reduce its permeability, so as to prevent
Or the material for the treatment of dental hypersensitiveness.For example, anti-sensitizer is included but is not limited to：Dipotassium glycyrrhizinate, potassium fluoride, potassium nitrate, chlorine
Change the potassium ion sources such as potassium.Preferably, in some specific embodiments, the anti-sensitizer includes potassium ion source.
Antiseptic is to refer within a certain period of time, protect the growth of certain micro-organisms in oral care composition or breeding
Hold in necessary chemical substance below horizontal.The antiseptic of example is included but is not limited to：Zinc oxide, stannous chloride, tetrahydrochysene turmeric
Element, cetylpyridinium chloride, triclosan etc..
Antilithic refers to the metal ion complex that can play a part of anti-tooth calculus.For example, antilithic includes
But it is not limited to：Pyrophosphate, tripolyphosphate, hexametaphosphate or citrate.
Whitening agent refers to the material that whitening function can be played to tooth.For example, whitening agent is included but is not limited to：Peroxide
Bleaching agent, papain, glucose oxidase.
The preparation method of oral care composition of the invention is to use method well known in the art, can be by reference to existing
Technology is carried out.Preparation method includes, the polyphenol compound particle of parcel is mixed with oral cavity acceptable carrier and is obtained
.
The polyphenol compound particle of the parcel in the present invention can be obtained using the conventional embedding means in this area.
Unless otherwise specified, the raw material in the present invention can be by the commercially available conventional method for being commercially available or passing through this area
Obtain.
In addition, unless otherwise specified, any scope described in the present invention includes any number between end value and end value
Any subrange that any number between value and end value or end value is constituted.
Beneficial effects of the present invention are as follows：
Wrapped up by by the polyphenol compound in oral care composition in the present invention, formed the Polyphenols of parcel
Compound particles, are improve at a temperature of normal temperature and high temperature (50 DEG C), and the stability of polyphenol compound in composition is improved existing
In some oral care compositions polyphenol compound can not be played well because being oxidized easily its anti-oxidation function and
The problem for easily making oral care composition change colour.
The specific wrappage of selection and parcel form are further advanced by the present invention, are further greatly improved many
Problem of the phenolic compound in the antioxidation and preventing and treating composition discoloration of normal temperature and high temperature (50 DEG C).
Specific embodiment
In order to illustrate more clearly of the present invention, with reference to preferred embodiment, the present invention is described further.Ability
Field technique personnel should be appreciated that following specifically described content is illustrative and be not restrictive, and should not limit this with this
The protection domain of invention.
Embodiment 1
First, a kind of oral care composition lotion product, its formula is as shown in table 1 below.
2nd, the preparation method of above-mentioned oral care composition such as comprises the following steps：
Other raw materials in formula in addition to the polyphenol particle 1 of parcel are configured to cream by the routinely preparation of lotion of toothpaste matrix
Body matrix；Particle 1 (the Tea Polyphenols particle of PLA parcel) is added, stir to obtain oral care composition lotion of the invention
Product.
Embodiment 2~8
The formula difference of the oral care composition lotion product of embodiment 2~8 is as shown in table 1 below, and preparation method is with real
Example 1 is applied, difference is that embodiment 2 and 6 changes the particle 1 in embodiment 1 into particle 2；Embodiment 3 and 7 is by embodiment 1
Particle 1 changes particle 3 into；Embodiment 4 and 8 changes the particle 1 in embodiment 1 into particle 4.
Comparative example 1~2
The formula difference of the oral care composition of comparative example 1~2 is as shown in table 1 below, and preparation method is with embodiment 1.Area
It is not that the particle 1 in embodiment 1 is changed into etc. comparative example 1 and 2 the Tea Polyphenols powder of particle diameter respectively.
Formula (embodiment 1~8 and the contrast of the embodiment of the present invention of table 1 and comparative example oral care composition lotion product
Example 1~2)
In above-mentioned table 1, the particle 1~4 during embodiment 1~8 is formulated is referred respectively to：
Particle 1：The Tea Polyphenols particle of PLA parcel, particle diameter is 355~600 microns；
Particle 2：The Tea Polyphenols particle of the mixing parcel of cornstarch and microcrystalline cellulose and PMMA, particle diameter is 355
~600 microns, wherein, the mass ratio of cornstarch, microcrystalline cellulose and PMMA is：1:0.5~8:0.5~2；
Particle 3：The Tea Polyphenols particle of polyacrylate parcel, particle diameter is 355~600 microns；
Particle 4：It is the Tea Polyphenols particle of two-layer integument parcel, particle diameter is 355~600 microns, wherein, kernel bag
Material is wrapped up in for paraffin oil, outer wall lapping is the mixture of fish glue and gum arabic.Paraffin oil, fish glue, gum arabic
Mass ratio be：1:0.1~8:0.1~8.
The Tea Polyphenols particle of the parcel of above-mentioned particle 1~4 is prepared by conventional embedding method.
In the formula of each embodiment of above-mentioned table 1 and comparative example, the content of Tea Polyphenols is the 167ppm of total raw material addition.
Experimental example 1 tests the Anti-tarnish property of resulting composition lotion product
Method of testing：Example 1~8 and the gained lotion product of comparative example 1~2, put at a temperature of 50 DEG C respectively
(i.e. aging) is put 1 month, with color difference meter, for example, U.S. X-Riet color difference meters (SP64) measures each embodiment and comparative example respectively
L*a*b values before and after the lotion aging of product, L*a*b systems provide the numerical expression of three-dimensional color space, and wherein L* can be used for cream
The measurement of body whiteness, L values are bigger, represent that lotion color is whiter, and L values are smaller, represent lotion color darker.L value changes are bigger,
Lotion color change is bigger.The difference of color is represented with △ L values before and after the lotion aging of product, as a result as shown in table 2 below.
The color difference of lotion product before and after table 2 is aging
| Product | The difference △ L of color before and after the aging of product |
| Embodiment 1 | -3.21 |
| Embodiment 2 | -2.94 |
| Embodiment 3 | -3.99 |
| Embodiment 4 | -1.35 |
| Comparative example 1 | -4.25 |
| Embodiment 5 | -2.1 |
| Embodiment 6 | -1.99 |
| Embodiment 7 | -1.95 |
| Embodiment 8 | -0.98 |
| Comparative example 2 | -2.93 |
Knowable to from upper table 2, after Tea Polyphenols particle is wrapped up, MC lotion product is preferably improved variable
The problem of color；Use two-layer parcel and kernel wrappage is paraffin oil and/or the mixture of silica colloidal, outer wall wrappage
For fish glue and gum arabic mixture when, to improve product discoloration problem it is better；Additionally, the appropriate fluorination of addition is sub-
After tin, the improvement to product discoloration problem is also more obvious.
The antioxygenic property of Tea Polyphenols in the research lotion product of experimental example 2
Test philosophy：Because Tea Polyphenols is mixture, be added into formula in after, it is impossible to further detect its content or whether
It is oxidized.EGCg is the main active of Tea Polyphenols, substantially accounts for the 60% of Tea Polyphenols total amount, and the content of EGCg can lead in formula
The method detection for crossing HPLC is obtained.Therefore, can be by measuring the situation of change of EGCg contents in product, so as to come in determining product
Tea Polyphenols antioxygenic property.
Method of testing：The lotion product that HPLC detection methods measure embodiment 5~8 and comparative example 2 is respectively adopted exists respectively
After placing 1 month (1M), 2 months (2M) and 3 months (3M) at a temperature of room temperature (25 DEG C or so), 40 DEG C of temperature and 50 DEG C, produce
The content of EGCg, as a result as shown in table 3 below in product, and the content of EGCg is the content for accounting for products material total addition level in table 3.
The content of EGCg in lotion product after different time is placed under the different temperatures of table 3
Knowable to from upper table 3, the product of the embodiment of the present invention is in room temperature and to preserving 3 months under 50 DEG C of hot conditions
During the above, the EGCg in product is kept at content very high, and this is also illustrated, the Tea Polyphenols in product still maintains high content
Level, the tea polyphenol stability after parcel improves, and with good anti-oxidation function；Use two-layer wrap up and kernel wrappage for
The mixture of paraffin oil and/or silica colloidal, when outer wall wrappage is the mixture of fish glue and gum arabic, foregoing effect
Fruit is more preferably.
Embodiment 9~12
The formula difference of the oral care composition lotion product of embodiment 9~12 is as shown in table 4 below, and preparation method is with real
Example 1 is applied, difference is that the particle in embodiment 9~12 is respectively particle a~particle d.
Comparative example 3
The formula of the oral care composition lotion product of comparative example 3 distinguishes as shown in table 4 below, the same embodiment of preparation method
1, difference is that the particle in embodiment 9~12 is Tea Polyphenols powder.
Formula (embodiment 9~12 and the contrast of the embodiment of the present invention of table 4 and comparative example oral care composition lotion product
Example 3)
In above-mentioned table 4, the particle a~particle b during embodiment 9~12 is formulated is referred respectively to：
Particle a：Integument is individual layer, the Tea Polyphenols particle of paraffin oil parcel；
Particle b：Integument is individual layer, the Tea Polyphenols particle of the mixture parcel of paraffin oil and silica colloidal, wherein,
The mass ratio of paraffin oil and silica colloidal is：30:1~20:1；
Particle c：Integument is two-layer, and kernel paraffin oil, outer wall is the tea of the mixture parcel of fish glue and gum arabic
Polyphenol particle, wherein, the mass ratio of paraffin oil, fish glue and gum arabic is 1:0.1~8:0.1~8；
Particle d：Integument is the mixture of two-layer, kernel paraffin oil and silica colloidal, outer wall be fish glue and I
The Tea Polyphenols particle of the mixture parcel of uncle's natural gum, wherein, the matter of paraffin oil, silica colloidal, fish glue and gum arabic
Amount is than being 1:0.03~0.05:0.1~8:0.1~8；
The Tea Polyphenols particle of above-mentioned particle a~d parcels is prepared by conventional embedding method, every kind of particle
Particle diameter in 50~1600 microns, average grain diameter is 300 microns.
In the formula of each embodiment of above-mentioned table 4 and comparative example, the content of Tea Polyphenols is total raw material addition
0.1wt%.
Using the inoxidizability of Tea Polyphenols in the technique study embodiment 9~12 and the product of comparative example 3 of above-mentioned experimental example 2
Can, it is as a result as shown in table 5 below.As can be known from Table 5, compare the integument of individual layer, when the integument of Tea Polyphenols particle is two-layer
When, the anti-oxidation function of Tea Polyphenols is more preferable；Compare kernel wrappage only paraffin oil, and outer wall wrappage is fish glue and Arab
Natural gum mixing, and formed parcel Tea Polyphenols particle, when use two-layer wrap up and kernel wrappage be paraffin oil and glue two
The mixture of silica, when outer wall wrappage is the mixture of fish glue and gum arabic, to improving product in Tea Polyphenols resist
Oxidative function effect is more notable.
The content of EGCg in lotion product after different time is placed under the different temperatures of table 5
Obviously, the above embodiment of the present invention is only intended to clearly illustrate example of the present invention, and is not right
The restriction of embodiments of the present invention, for those of ordinary skill in the field, may be used also on the basis of the above description
To make other changes in different forms, all of implementation method cannot be exhaustive here, it is every to belong to this hair
Obvious change that bright technical scheme is extended out changes row still in protection scope of the present invention.
Claims (14)
1. a kind of oral care composition, it is characterised in that the oral care composition is included：
The polyphenol compound particle of parcel；With,
Oral cavity acceptable carrier.
2. oral care composition according to claim 1, it is characterised in that the polyphenol compound particle of the parcel
Lapping be selected from PLA, cornstarch, microcrystalline cellulose, polymethyl methacrylate, polyacrylate, fish glue, Ah
Draw the mixing of one or more in uncle's natural gum, paraffin oil and silica colloidal.
3. oral care composition according to claim 1, it is characterised in that the polyphenol compound particle of the parcel
Wrappage be selected from fish glue, gum arabic, paraffin oil and silica colloidal in the mixing of one or more.
4. the oral care composition according to any one of claims 1 to 3, it is characterised in that the Polyphenols of the parcel
Compound particles include kernel and outer wall.
5. oral care composition according to claim 4, it is characterised in that the kernel lapping is paraffin oil
And/or the mixture of silica colloidal.
6. oral care composition according to claim 4, it is characterised in that the outer wall lapping be fish glue and Ah
Draw the mixture of uncle's natural gum.
7. the oral care composition according to any one of claim 1~6, it is characterised in that the Polyphenols of the parcel
In compound particles, the addition of polyphenol compound accounts for more than the 0.1ppm of oral care composition total amount, preferably 1ppm
More than, more preferably 0.001%~3%, most preferably 0.01%~2%.
8. oral care composition according to claim 7, it is characterised in that by mass percentage, the parcel
The addition of polyphenol compound particle is the 0.01%~5%, preferably 0.1%~1.5% of oral care composition total amount,
More preferably 0.1%~0.7%, most preferably 0.2%~0.5%.
9. the oral care composition according to any one of claim 1~8, it is characterised in that the polyphenol compound
Comprising one or more in following compound：Epigallo-catechin gallate (EGCG), L-Epicatechin gallate, catechu
Acid, epicatechin, epigallocatechin and chlorogenic acid.
10. the oral care composition according to any one of claim 1~9, it is characterised in that the polyphenol compound
It is Tea Polyphenols.
11. oral care composition according to any one of claim 1~10, it is characterised in that by mass percentage,
Also comprising water-soluble stannous ion source in the oral care composition.
12. oral care compositions according to claim 11, it is characterised in that the water-soluble stannous ion source is selected from
Stannous fluoride, stannous chloride, stannous pyrophosphate, phosphoric acid stannous chloride, stannous bromide, stannous iodide, stannous oxide, stannous sulfide, partially
Phosphoric acid stannous chloride, stannous acetate, stannous tartrate, stannous citrate, stannous malate, malonic acid stannous, gluconic acid stannous and
One or more in stannous oxalate.
13. oral care compositions according to claim 12, it is characterised in that wherein described water-soluble stannous ion source
Mass ratio with polyphenol compound is more than 1.5:1.
14. oral care compositions according to claim 13, it is characterised in that wherein described water-soluble stannous ion source
Account for the 0.001%~5% of oral care composition weight, preferably 0.05~2%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468587A (en) * | 2017-09-14 | 2017-12-15 | 好维股份有限公司 | It is a kind of to include the oral care composition for stablizing polyphenol |
| CN113456546A (en) * | 2021-06-24 | 2021-10-01 | 上海乐宝日化股份有限公司 | Oral care solution |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110107A (en) * | 2013-01-20 | 2013-05-22 | 浙江大学 | Method for wrapping tea polyphenol by using protein gel |
| CN103571496A (en) * | 2012-07-18 | 2014-02-12 | 华东理工大学 | Chitosan microsphere with high oxidation resistance and its preparation method |
| CN104223078A (en) * | 2014-09-26 | 2014-12-24 | 天津市聚星康华医药科技有限公司 | Tea polyphenol oral cavity instant film and preparation method thereof |
| CN106074192A (en) * | 2016-07-01 | 2016-11-09 | 好来化工(中山)有限公司 | Antioxidative oral care composition |
-
2017
- 2017-01-22 CN CN201710045566.XA patent/CN106798662B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103571496A (en) * | 2012-07-18 | 2014-02-12 | 华东理工大学 | Chitosan microsphere with high oxidation resistance and its preparation method |
| CN103110107A (en) * | 2013-01-20 | 2013-05-22 | 浙江大学 | Method for wrapping tea polyphenol by using protein gel |
| CN104223078A (en) * | 2014-09-26 | 2014-12-24 | 天津市聚星康华医药科技有限公司 | Tea polyphenol oral cavity instant film and preparation method thereof |
| CN106074192A (en) * | 2016-07-01 | 2016-11-09 | 好来化工(中山)有限公司 | Antioxidative oral care composition |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468587A (en) * | 2017-09-14 | 2017-12-15 | 好维股份有限公司 | It is a kind of to include the oral care composition for stablizing polyphenol |
| CN107468587B (en) * | 2017-09-14 | 2020-09-22 | 好维股份有限公司 | An oral care composition comprising stabilized polyphenols |
| CN113456546A (en) * | 2021-06-24 | 2021-10-01 | 上海乐宝日化股份有限公司 | Oral care solution |
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