CN108743424B - Oral care composition for tooth remineralization - Google Patents
Oral care composition for tooth remineralization Download PDFInfo
- Publication number
- CN108743424B CN108743424B CN201810732269.7A CN201810732269A CN108743424B CN 108743424 B CN108743424 B CN 108743424B CN 201810732269 A CN201810732269 A CN 201810732269A CN 108743424 B CN108743424 B CN 108743424B
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- CN
- China
- Prior art keywords
- zinc
- oral care
- care composition
- solubility
- water
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- 239000000203 mixture Substances 0.000 title claims abstract description 76
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 27
- 150000003751 zinc Chemical class 0.000 claims abstract description 21
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 17
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 16
- 239000001509 sodium citrate Substances 0.000 claims description 9
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 9
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 8
- 229940091249 fluoride supplement Drugs 0.000 claims description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 8
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 8
- 239000011787 zinc oxide Substances 0.000 claims description 8
- 239000001508 potassium citrate Substances 0.000 claims description 6
- 229960002635 potassium citrate Drugs 0.000 claims description 6
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 6
- 235000011082 potassium citrates Nutrition 0.000 claims description 6
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 claims description 6
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 5
- 239000011670 zinc gluconate Substances 0.000 claims description 5
- 235000011478 zinc gluconate Nutrition 0.000 claims description 5
- 229960000306 zinc gluconate Drugs 0.000 claims description 5
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 4
- 239000011775 sodium fluoride Substances 0.000 claims description 4
- 235000013024 sodium fluoride Nutrition 0.000 claims description 4
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 4
- 239000011592 zinc chloride Substances 0.000 claims description 4
- 235000005074 zinc chloride Nutrition 0.000 claims description 4
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 3
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 3
- 239000004246 zinc acetate Substances 0.000 claims description 3
- 229960000314 zinc acetate Drugs 0.000 claims description 3
- 229940071566 zinc glycinate Drugs 0.000 claims description 3
- 239000011576 zinc lactate Substances 0.000 claims description 3
- 235000000193 zinc lactate Nutrition 0.000 claims description 3
- 229940050168 zinc lactate Drugs 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 abstract description 14
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- 239000003795 chemical substances by application Substances 0.000 description 9
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- 239000000126 substance Substances 0.000 description 8
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 8
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- 239000002253 acid Substances 0.000 description 4
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000004110 Zinc silicate Substances 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 239000000043 antiallergic agent Substances 0.000 description 3
- 239000007844 bleaching agent Substances 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000007654 immersion Methods 0.000 description 3
- 238000001000 micrograph Methods 0.000 description 3
- 230000000395 remineralizing effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
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- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 3
- 229910000165 zinc phosphate Inorganic materials 0.000 description 3
- OMSYGYSPFZQFFP-UHFFFAOYSA-J zinc pyrophosphate Chemical compound [Zn+2].[Zn+2].[O-]P([O-])(=O)OP([O-])([O-])=O OMSYGYSPFZQFFP-UHFFFAOYSA-J 0.000 description 3
- XSMMCTCMFDWXIX-UHFFFAOYSA-N zinc silicate Chemical compound [Zn+2].[O-][Si]([O-])=O XSMMCTCMFDWXIX-UHFFFAOYSA-N 0.000 description 3
- 235000019352 zinc silicate Nutrition 0.000 description 3
- PQHYOGIRXOKOEJ-UHFFFAOYSA-N 2-(1,2-dicarboxyethylamino)butanedioic acid Chemical compound OC(=O)CC(C(O)=O)NC(C(O)=O)CC(O)=O PQHYOGIRXOKOEJ-UHFFFAOYSA-N 0.000 description 2
- SZHQPBJEOCHCKM-UHFFFAOYSA-N 2-phosphonobutane-1,2,4-tricarboxylic acid Chemical class OC(=O)CCC(P(O)(O)=O)(C(O)=O)CC(O)=O SZHQPBJEOCHCKM-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
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- 208000006558 Dental Calculus Diseases 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
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- 230000003628 erosive effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- DBLXOVFQHHSKRC-UHFFFAOYSA-N ethanesulfonic acid;2-piperazin-1-ylethanol Chemical compound CCS(O)(=O)=O.OCCN1CCNCC1 DBLXOVFQHHSKRC-UHFFFAOYSA-N 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229940104869 fluorosilicate Drugs 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000004283 incisor Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002701 inhibitory effect on caries Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- ORUIBWPALBXDOA-UHFFFAOYSA-L magnesium fluoride Chemical compound [F-].[F-].[Mg+2] ORUIBWPALBXDOA-UHFFFAOYSA-L 0.000 description 1
- 229910001635 magnesium fluoride Inorganic materials 0.000 description 1
- 239000011742 magnesium glycerophosphate Substances 0.000 description 1
- 235000001130 magnesium glycerophosphate Nutrition 0.000 description 1
- BHJKUVVFSKEBEX-UHFFFAOYSA-L magnesium;2,3-dihydroxypropyl phosphate Chemical compound [Mg+2].OCC(O)COP([O-])([O-])=O BHJKUVVFSKEBEX-UHFFFAOYSA-L 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229940080237 sodium caseinate Drugs 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000001119 stannous chloride Substances 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- GYBINGQBXROMRS-UHFFFAOYSA-J tetrasodium;2-(1,2-dicarboxylatoethylamino)butanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC(C([O-])=O)NC(C([O-])=O)CC([O-])=O GYBINGQBXROMRS-UHFFFAOYSA-J 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an oral care composition for tooth remineralization, which is characterized in that: comprises nano hydroxyapatite, a polycarboxy compound and zinc salt with the solubility of less than or equal to 0.001g/100ml in water at 20 ℃. The oral care composition can increase the thickness of the remineralization layer, preventing re-demineralization of the remineralization layer.
Description
Technical Field
The invention relates to the technical field of oral care, in particular to an oral care composition for tooth remineralization.
Background
In daily life, bacteria in the oral cavity digest carbohydrate substances in food residues to produce acid or ingestion of acidic foods can cause tooth demineralization. If the pH of the oral cavity is locally <5.5, hydroxyapatite (HAp) on the enamel surface will dissolve, a process called demineralization. After the tooth surface loses enamel, fragile dentin and dentin tubules are exposed, so that dental caries, dentin sensitivity and other oral problems are caused. Research into tooth remineralization has been carried out for decades, and there are now some technologies for promoting tooth remineralization and inhibiting demineralization, in which bioactive materials have been widely focused in recent years due to their good biocompatibility. HAp is the main inorganic constituent of teeth, has good bioactivity and biocompatibility, and has been reported in recent years for tooth remineralization. The second sixteen volumes of the oral care industry, in vitro studies of toothpaste containing nano HAp and micron HAp on demineralized dentin, reported that toothpaste containing nano HAp and micron HAp has biomineralization repairing efficacy on demineralized dentin tubules. The influence of nano-hydroxyapatite on the remineralization of enamel early caries is reported in the "experimental study of the influence of nano-hydroxyapatite on enamel remineralization" in volume 16, phase 2 of journal of dental pulp and dental periodontal disease, indicating that nano-hydroxyapatite can promote enamel remineralization; in addition, chinese patent CN1751678a discloses "application of nano hydroxyapatite in toothpaste", which adds needle hydroxyapatite smaller than 50 nm into common toothpaste to make the toothpaste have effect of repairing teeth; chinese patent CN102227204a discloses an "oral care composition" comprising particulate hydroxyapatite, a fluoride source, a potassium cation source and a citrate anion source. The composition may be for anticaries, for remineralization of teeth, or for reducing hypersensitivity. Although HAp has a restorative effect on damaged teeth, the restored teeth still have the potential to be demineralized again under acid stimulation. In order to increase the resistance of teeth to acid erosion, it is desirable to increase the thickness of the remineralisation layer, or to increase the compactness and hardness of the remineralisation layer.
Disclosure of Invention
The technical problem to be solved by the present application is to provide an oral care composition for tooth remineralization. The oral care composition can increase the thickness of the remineralization layer, preventing re-demineralization of the remineralization layer.
In order to solve the technical problems, the invention adopts the following technical scheme:
An oral care composition for remineralisation of teeth comprising nano-hydroxyapatite, a polycarboxy compound and a zinc salt having a solubility in water of less than or equal to 0.001g/100ml at 20 ℃.
Preferably, the nano-hydroxyapatite is added in an amount of 0.5 to 25wt% based on the total weight of the composition.
Preferably, the polycarboxy compound is added in an amount of 0.5 to 15.0 weight percent based on the total weight of the composition.
Preferably, the zinc salt is added in an amount of 0.5 to 5.0wt% based on the total weight of the composition, with a solubility in water of less than or equal to 0.001g/100ml at 20 ℃.
As a further improvement of the technical scheme, the zinc salt with the solubility in water of less than or equal to 0.001g/100ml at 20 ℃ comprises one or more of zinc oxide, zinc phosphate, zinc pyrophosphate, zinc silicate, zinc oleate, zinc hydroxide, zinc peroxide and zinc sulfide.
Preferably, the zinc salt with the solubility in water at 20 ℃ being less than or equal to 0.001g/100ml is zinc oxide.
As a further improvement of the technical scheme, the polycarboxylic compound comprises one or more of citrate compound, polyaspartate, iminodisuccinate, 2-phosphonobutane-1, 2, 4-tricarboxylic acid salt (PBTCA. Na 4 for short) and polyacrylate.
Preferably, the polycarboxy compound is a citrate compound.
Preferably, the citrate compound comprises one or more of potassium citrate, sodium citrate and zinc citrate.
Preferably, the citrate compound is a mixture of potassium citrate and zinc citrate.
Preferably, the citrate compound is a mixture of sodium citrate and zinc citrate.
Preferably, the zinc citrate is zinc citrate trihydrate.
As a further improvement of the technical scheme, the oral care composition further comprises zinc salt with a solubility > 0.001g/100ml in water at 20 ℃.
Preferably, the zinc salt with the solubility of more than 0.001g/100ml in water at 20 ℃ comprises one or more of zinc chloride, zinc lactate, zinc nitrate, zinc acetate, zinc gluconate, zinc glycinate and zinc sulfate.
As a further improvement of the technical solution, the oral care composition further comprises fluoride.
Preferably, the fluoride comprises sodium fluoride or sodium monofluorophosphate.
Any range recited in the invention includes any numerical value between the endpoints and any sub-range of any numerical value between the endpoints or any numerical value between the endpoints.
Unless otherwise indicated, all starting materials herein are commercially available, and the equipment used in the present invention may be conventional in the art or may be conventional in the art.
Compared with the prior art, the invention has the following beneficial effects:
the oral care composition of the present invention can increase the thickness of the remineralization layer, preventing re-demineralization of the remineralization layer.
Drawings
FIG. 1 is a Scanning Electron Microscope (SEM) of the surface of a dentin sample after acid etching;
FIG. 2 is a scanning electron microscope image of a dentin sample after 14 days of immersion with the formulation of example 1;
FIG. 3 is a scanning electron microscope image of a dentin sample after 14 days immersion with the formulation of example 2;
FIG. 4 is a scanning electron microscope image of a dentin sample after 14 days of immersion with the formulation of example 3;
Detailed Description
In order to more clearly illustrate the present invention, the present invention will be further described with reference to preferred embodiments. It is to be understood by persons skilled in the art that the following detailed description is illustrative and not restrictive, and that this invention is not limited to the details given herein.
In the present invention, the thickness of the remineralized layer is measured as follows:
1. dentin sample preparation
Preparation of bovine tooth slices: taking bovine incisors, cutting root slices with the thickness of 2mm at the position 2mm away from the junction between the root and the tooth surface, and then respectively grinding the root slices into slices with the thickness of about 2mm x 6mm by using 400-mesh sand paper and 2500-mesh sand paper to expose dentin tubules; soaking polished dentin slices with 6% citric acid for 5min, washing with deionized water for 15min, picking out completely opened dentin tubule sample under a crystal phase microscope (see figure 1), and performing ultrasonic treatment with deionized water for 3 times and 15min each time for use;
2. artificial saliva deployment
20MMHEPES (4-hydroxyethyl piperazine ethanesulfonic acid ),16mMKCl,1mMCaCl2.2H2O,4mMKH2PO4,4.5mMNH4Cl,0.2mMMgCl2.6H2O, ph=7.0 with 1mol/LKOH solution) (referred to as 4.766gHEPES,1.1928gKCl,0.14701gCaCl2.2H2O,0.54436gKH2PO4,0.2407gNH4Cl,0.04066gMgCl2.6H2O)
The configuration method comprises the following steps: the above materials were dissolved in 850mL deionized water, one material was completely dissolved and then the other material was added, caCl 2.2H2 O was dissolved before KH 2PO4, and after all dissolution, ph=7.0 was adjusted with 1mol/l koh solution. Then metering the volume in a 1L volumetric flask (recall that the pH electrode and beaker are rinsed, and these rinses are also metering into the volumetric flask);
3. the instrument used is as follows: hitachi S-4800 cold field emission scanning electron microscope
The experimental steps are as follows:
taking 1g of the uniform suspension of examples 1-14 into a beaker, respectively placing the treated dentin slices, soaking for 3min, and washing with 80mL of deionized water for 15s after soaking is finished to clean the tooth surfaces; placing in artificial saliva for 6h (10 mL of artificial saliva for each sample) after washing; repeating the soaking of the uniform suspension for 3min, washing with deionized water, and then placing into artificial saliva for 18h (10 mL of artificial saliva for each sample, and 10 μl of the suspension of the corresponding example); after 14 days of cycling, SEM dentin sample surface Scanning Electron Microscopy (SEM) testing was performed.
The invention relates to an oral care composition for tooth remineralization, which comprises nano hydroxyapatite, a polycarboxy compound and zinc salt with the solubility in water at 20 ℃ being less than or equal to 0.001g/100 ml.
The present application surprisingly found that the combination of nano-hydroxyapatite, a polycarboxy compound and a zinc salt having a solubility in water of less than or equal to 0.001g/100ml at 20 ℃ is effective in increasing the thickness of the remineralised layer.
In certain embodiments of the invention, the nano-hydroxyapatite is added in an amount of 0.5 to 25wt%, or 1 to 22wt%, or 1 to 19wt%, or 1 to 16wt%, or 1 to 13wt%, or 1 to 10wt%, or 1 to 8wt%, or 1 to 6wt%, or 1 to 4wt%, or 4 to 25wt%, or 4 to 22wt%, or 4 to 19wt%, or 4 to 16wt%, or 4 to 13wt%, or 4 to 10wt%, or 4 to 8wt%, or 4 to 6wt%, or 7 to 25wt%, or 7 to 22wt%, or 7 to 19wt%, or 7 to 16wt%, or 7 to 13wt%, or 7 to 10wt%, or 10 to 25wt%, or 10 to 22wt%, or 10 to 19wt%, or 10 to 16wt%, or 10 to 13wt%, or 13 to 25wt%, or 13 to 22wt%, or 13 to 19wt%, or 13 to 16wt%, or 16 to 25wt%, or 16 to 22wt%, or 19 to 25wt%, or 22wt% of the total weight of the composition.
In certain embodiments of the present invention, the polycarboxy compound is added in an amount of 0.5 to 15wt%, or 1 to 13wt%, or 1 to 11wt%, or 1 to 9wt%, or 1 to 7wt%, or 1 to 5wt%, or 1 to 3wt%, or 3 to 15wt%, or 3 to 13wt%, or 3 to 11wt%, or 3 to 9wt%, or 3 to 7wt%, or 3 to 5wt%, or 5 to 15wt%, or 5 to 13wt%, or 5 to 11wt%, or 5 to 9wt%, or 5 to 7wt%, or 7 to 15wt%, or 7 to 13wt%, or 7 to 11wt%, or 7 to 9wt%, or 9 to 15wt%, or 9 to 13wt%, or 9 to 11wt%, or 11 to 15wt%, or 11 to 13wt%, or 13 to 15wt%, or 13wt% or 13 to 15wt% based on the total weight of the composition.
In certain embodiments of the present invention, the zinc salt having a solubility in water of less than or equal to 0.001g/100ml at 20℃is added in an amount of 0.5 to 5.0wt%, or 0.5 to 4.5wt%, or 0.5 to 4wt%, or 0.5 to 3.5wt%, or 0.5 to 3wt%, or 0.5 to 2.5wt%, or 0.5 to 2wt%, or 0.5 to 1.5wt%, or 0.5 to 1wt%, or 1 to 4.5wt%, or 1 to 4wt%, or 1 to 3.5wt%, or 1 to 3wt%, or 1 to 2.5wt%, or 2 to 4.5wt%, or 2 to 4wt%, or 2 to 3.5wt%, or 3 to 4.5wt%, or 3 to 3.5wt%, or 4.5wt%, or 4 to 4.5wt% of the total weight of the composition.
In certain embodiments of the present invention, the zinc salt having a solubility in water of less than or equal to 0.001g/100ml at 20 ℃ comprises one or more of zinc oxide, zinc phosphate, zinc pyrophosphate, zinc silicate, zinc oleate, zinc hydroxide, zinc peroxide, and zinc sulfide.
In certain preferred embodiments of the present invention, the zinc salt having a solubility in water of less than or equal to 0.001g/100ml at 20 ℃ is zinc oxide.
In certain embodiments of the present invention, the polycarboxy compound comprises one or more of citrate, polyaspartate, iminodisuccinate, 2-phosphonobutane-1, 2, 4-tricarboxylic acid salt (abbreviated as PBTCA. Na 4), polyacrylate.
In certain preferred embodiments of the present invention, the polycarboxy compound is a citrate compound.
In certain preferred embodiments of the present invention, the citrate compound comprises one or more of potassium citrate, sodium citrate, zinc citrate.
In certain preferred embodiments of the present invention, the citrate compound is a mixture of potassium citrate and zinc citrate.
In certain preferred embodiments of the present invention, the citrate compound is a mixture of sodium citrate and zinc citrate.
In certain preferred embodiments of the present invention, the zinc citrate is zinc citrate trihydrate.
In certain embodiments of the present invention, the oral care composition further comprises a zinc salt having a solubility in water of > 0.001g/100ml at 20 ℃.
In certain preferred embodiments of the present invention, the zinc salt having a solubility in water of > 0.001g/100ml at 20 ℃ comprises one or more of zinc chloride, zinc lactate, zinc nitrate, zinc acetate, zinc gluconate, zinc glycinate, zinc sulfate.
In certain embodiments of the present invention, the oral care composition further comprises a fluoride.
In certain embodiments of the present invention, the fluoride comprises one or more of sodium fluoride, potassium fluoride, calcium fluoride, magnesium fluoride, stannous fluoride, ammonium fluoride, sodium monofluorophosphate, potassium monofluorophosphate, fluorosilicate.
In certain preferred embodiments of the present invention, the fluoride comprises sodium fluoride or sodium monofluorophosphate.
In certain embodiments of the present invention, adjuvants such as abrasives, humectants, flavoring agents, and/or thickening agents may be further included in the oral care compositions.
In certain embodiments of the present invention, the oral care composition may further comprise an active ingredient such as an antibacterial agent, anticaries agent, antiallergic agent, anticalculus agent, and/or whitening agent.
The oral care compositions of the present invention may be applied in toothpaste or mouthwash.
The abrasive is the main raw material of the toothpaste, and the most important function in the toothpaste is to remove dental calculus and alleviate dental calculus. The abrasive should be selected with full consideration of its hardness, size, shape and content to ensure effective cleaning without abrading the teeth. Exemplary abrasives may include, but are not limited to, one or more of the following: calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, silica, tricalcium phosphate, aluminum silicate, aluminum hydroxide, aluminum oxide, zeolite, titanium oxide, silicic acid, kaolin, and the like.
"Humectant" is an ingredient that prevents the dehydration and hardening of an oral care composition. Exemplary humectants include, but are not limited to, for example, glycerin, propylene glycol, sorbitol, low molecular weight polyethylene glycols, and the like. The humectant is typically present in the oral care composition in an amount of from 10 to 80% by mass.
A "thickener" is a substance that increases the viscosity of a solution or liquid/solid mixture, but does not substantially change its properties. The purpose of the thickener is to provide the product with a skeleton, flowability and stability. Exemplary thickening agents include, but are not limited to, one or more of hydroxyethylcellulose, carboxymethylcellulose and salts thereof (e.g., sodium carboxymethylcellulose), carrageenan (carrageenan), carboxyvinyl polymers, xanthan gum (xanthangum), carrageenan, gelatin, pullulan, sodium alginate, and the like. In certain embodiments, the thickening agent comprises one or more of xanthan gum, carrageenan, or sodium carboxymethyl cellulose. The weight proportion of thickener in the oral care composition is typically from 0.2 to 2%.
The "surfactant" serves the purpose of emulsifying the flavor and foaming in the toothpaste, and can assist in the adequate and complete dispersion of the hydroxyapatite-polycarboxy compound complex to some extent. Exemplary surfactants include, but are not limited to, anionic surfactants such as sodium dodecyl sulfate; amphoteric surfactants such as betaine; amino acid surfactants such as sodium lauroyl sarcosinate and nonionic surfactants such as polyoxyethylene and polyoxypropylene copolymers, polyethylene glycol, and the like. The weight proportion of the surfactant in the oral care composition is typically from 0.5 to 2.5%.
According to certain embodiments of the present application, the oral care composition may further comprise active ingredients such as antibacterial agents, anticaries agents, antiallergic agents, anticalculus agents, and/or whitening agents;
"antibacterial agent" refers to a chemical substance that is capable of maintaining the growth or proliferation of certain microorganisms in an oral care composition below a requisite level for a period of time. Exemplary antimicrobial agents include, but are not limited to: stannous chloride, tetrahydrocurcumin, cetylpyridinium chloride, triclosan, and the like.
"Anticaries agent" refers to a substance that has an inhibitory effect on caries, such as a substance that can enhance the anticaries ability of the tooth by reducing the solubility of hydroxyapatite of the enamel, or a substance that controls plaque, inhibits bacterial growth. Exemplary anticaries agents include, but are not limited to, phosphorous-containing agents (calcium phosphate, sodium trimetaphosphate, magnesium glycerophosphate, milk calcium phosphate, sodium caseinate, and the like), or arginine and derivatives thereof.
"Antiallergic agent" means a substance capable of preventing or treating dentinal hypersensitivity by inhibiting nerve impulse or by blocking dentinal tubules or reducing its permeability. Exemplary anti-sensitizers include, but are not limited to: dipotassium glycyrrhizinate, potassium fluoride, potassium nitrate, potassium chloride and other potassium ion sources. Preferably, in certain embodiments, the anti-sensitization agent comprises a source of potassium ions.
An "anticalculus agent" refers to a metal ion complex that is capable of acting as an anticalculus agent. Exemplary anticalculus agents include, but are not limited to: pyrophosphates, tripolyphosphates, hexametaphosphates or citrates.
"Whitening agent" refers to a substance that has a whitening effect on teeth. Exemplary whitening agents include, but are not limited to: peroxide bleach, papain, glucose oxidase.
Examples 1 to 7:
an oral care composition is formulated as a suspension according to the formulation of Table 1 in a conventional manner.
TABLE 1
Example 8
An oral care composition is formulated as a suspension according to the formulation of Table 2 in a conventional manner.
TABLE 2
Example 9
An oral care composition is formulated as a suspension according to the formulation of Table 3 in a conventional manner.
TABLE 3 Table 3
Example 10
An oral care composition is formulated as a suspension according to the formulation of Table 4 in a conventional manner.
TABLE 4 Table 4
Example 11
An oral care composition is formulated as a suspension according to the formulation of Table 5 in a conventional manner.
TABLE 5
Example 12
An oral care composition was formulated as a suspension according to the formulation of Table 6.
TABLE 6
Example 13
An oral care composition was formulated as a suspension according to the conventional method as described in table 7 below.
TABLE 7
Example 14
An oral care composition was formulated as a suspension according to the formulation of Table 8.
TABLE 8
From tables 1-8, it can be seen that: 1) The remineralization layer had a thickness of 0.75 μm when the composition contained only 2.5% nano-hydroxyapatite and 1% zinc oxide, and 1 μm when the composition contained only 2.5% nano-hydroxyapatite and 5% sodium citrate (see fig. 3); 2) When the composition contained both 2.5% nano-hydroxyapatite, 5% sodium citrate and 1% zinc oxide, the remineralised layer thickness increased to 6 μm (see fig. 4). In conclusion, when the composition contains three components of nano hydroxyapatite, a polycarboxy compound and zinc salt with the solubility in water at 20 ℃ being less than or equal to 0.001g/100ml, the thickness of the remineralizing layer is obviously improved.
It can also be seen from tables 1-8: when the content of the above three components in the composition is increased, the thickness of the remineralizing layer is also increased correspondingly.
It can also be seen from tables 1-8: when sodium citrate in the composition is changed into sodium polyaspartate, sodium iminodisuccinate and sodium polyacrylate, or zinc oxide in the composition is changed into zinc silicate, zinc phosphate and zinc pyrophosphate, the thickness of the remineralizing layer is obviously improved compared with that of the embodiment 1 and the embodiment 2.
Examples 15 to 19
A toothpaste was formulated according to the following Table 9 formulation in a conventional manner.
TABLE 9
The remineralization layer thicknesses were measured as follows for the experimental procedures described in examples 15-20 above:
1. dentin preparation and artificial saliva configuration as above;
2. the instrument used is as follows: hitachi S-4800 cold field emission scanning electron microscope
3. Brushing teeth of different dentin samples with toothpaste of example 15-20 (1 g paste is weighed respectively) for 2min, and washing with 80mL deionized water for 15s after brushing to clean tooth surface; placing in artificial saliva for 6h after washing (10 mL of artificial saliva for each sample, and adding 10 μl of the supernatant of toothpaste water of the corresponding example); repeatedly brushing teeth for 2min by using toothpaste, washing with deionized water, and then adding artificial saliva for 18h (10 mL of artificial saliva for each sample, and adding 10 μl of supernatant of toothpaste of corresponding example); after 14 days of cycling, SEM testing was performed with the results shown in table 10 below:
Table 10
It can be seen from Table 10 that the remineralization layer thickness further increases when soluble zinc salts such as zinc chloride, zinc gluconate and the like are added to the formulation.
Examples 21 to 22
A toothpaste was prepared according to the following Table 11 formulation in a conventional manner. For comparative convenience, the formulation of example 15 is listed together in table 11 below.
Table 11.
The dentin surface microhardness was measured in the following experimental procedures in examples 15, 21 and 22 described above:
1. dentin preparation and artificial saliva configuration as above;
2. Instrument: measuring dentin surface microhardness by Shimadzu HMV-2T microhardness meter
3. Brushing teeth of different dentin samples for 2min by using toothpaste of example 15, toothpaste of example 21 and toothpaste of example 22 (1 g of paste is weighed respectively), and washing with 80mL deionized water for 15s after brushing to clean tooth surfaces; placing in artificial saliva for 6h after washing (10 mL of artificial saliva for each sample, and adding 10 μl of the supernatant of toothpaste water of the corresponding example); repeatedly brushing teeth for 2min by using toothpaste, washing with deionized water, and then adding artificial saliva for 18h (10 mL of artificial saliva for each sample, and adding 10 μl of supernatant of toothpaste of corresponding example); after 14 days of circulation, hardness test was carried out, and the hardness tester was used with a vickers diamond cone indenter, a load of 25g and a duration of 10s, 3 points were measured for each dentin sample, and the distance between each point was 50 μm, and the average value was obtained. The second measurement point was spaced 100 microns from the first measurement point and the hardness results are shown in Table 12 below:
Table 12
| Example 15 | Example 21 | Example 22 | |
| Hardness/Gpa | 0.8 | 1.21 | 1.34 |
It can be seen from table 12 that the hardness of the remineralised layer is significantly improved when the formulation is added with the fluorine-containing compound, especially when the formulation is added with both the fluorine-containing compound and the soluble zinc gluconate.
It is to be understood that the above examples of the present invention are provided by way of illustration only and not by way of limitation of the embodiments of the present invention. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. Not all embodiments are exhaustive. All obvious changes or modifications which come within the spirit of the invention are desired to be protected.
Claims (5)
1. An oral care composition for tooth remineralization, characterized by: comprises nano hydroxyapatite, potassium citrate or sodium citrate and zinc salt with the solubility of less than or equal to 0.001g/100ml in water at 20 ℃;
The addition amount of the nano hydroxyapatite is 2.5 weight percent of the total weight of the composition;
the addition amount of the potassium citrate or the sodium citrate is 5 weight percent of the total weight of the composition;
The addition amount of the zinc salt with the solubility in water at 20 ℃ being less than or equal to 0.001g/100ml is 1wt% of the total weight of the composition;
the zinc salt with the solubility less than or equal to 0.001g/100ml in water at 20 ℃ is zinc oxide.
2. An oral care composition for tooth remineralization according to claim 1, wherein: the oral care composition further comprises a zinc salt having a solubility in water of > 0.001g/100ml at 20 ℃.
3. The oral care composition for tooth remineralization according to claim 2, wherein: the zinc salt with the solubility of more than 0.001g/100ml in water at 20 ℃ is one or more of zinc chloride, zinc lactate, zinc nitrate, zinc acetate, zinc gluconate, zinc glycinate and zinc sulfate.
4. An oral care composition for tooth remineralization according to claim 1, wherein: the oral care composition further comprises a fluoride.
5. An oral care composition for tooth remineralization according to claim 4, wherein: the fluoride includes sodium fluoride or sodium monofluorophosphate.
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| AU2019468797A1 (en) | 2019-09-30 | 2022-03-17 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
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