CN110801404A - Dihydromyricetin-containing tooth whitening and repairing toothpaste and preparation method thereof - Google Patents
Dihydromyricetin-containing tooth whitening and repairing toothpaste and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a dihydromyricetin-containing tooth whitening and repairing toothpaste and a preparation method thereof, wherein the preparation method comprises the following steps: adding purified water into a pre-dissolving pot, adding water-soluble raw materials such as dihydromyricetin and sodium phytate into the pre-dissolving pot, stirring and mixing the solution to form an aqueous solution, adding a toothpaste friction agent into a pre-mixing powder pot, uniformly dispersing to obtain powder, pumping a humectant into the pre-dispersing pot, dispersing an adhesive thickener into the pre-dispersing pot, pumping the material into a vacuum paste making machine, homogenizing, grinding and uniformly stirring, cooling, adding a foaming agent into the vacuum paste making machine, stirring at a medium speed to homogenize, sucking other substances, stirring, sampling and detecting the qualified paste, and filling to obtain the tooth whitening and repairing toothpaste.
Description
Technical Field
The invention relates to the field of toothpaste, in particular to dihydromyricetin-containing tooth whitening and repairing toothpaste and a preparation method thereof.
Background
In the oral environment, tooth stains are often mixed with extrinsic stains on the tooth surface, the formation of which is based on the acquired film. The saliva-acquired membrane is formed by selective adsorption of glycoproteins in saliva to the tooth surface, and is a thin, cell-free, unstructured, homogeneous organic membrane, which is about a few microns thick. The acquired membrane contains amino acids, proteins, carbohydrates, lipids and other substances, and can be formed on the surfaces of fillings, dental calculus, restoration and appliance in the tooth surface and oral cavity through the action of ion charges. After the acquired membrane is formed, bacteria, dietary pigment such as tea, coffee, soy sauce and the like can be adhered to the acquired membrane to form tooth surface stains or tooth surface exogenous stains, and the acquired membrane has a promotion on the occurrence and the development of dental caries and periodontal diseases. Therefore, removing the stain on the tooth surface based on the acquired pellicle can whiten teeth, reduce pathogenic bacteria in the oral cavity, clean the oral cavity, and contribute to the prevention and treatment of caries and periodontal disease.
The invention improves the prior art, and the whitening principles of the existing tooth whitening and repairing toothpaste mainly comprise three types: the physical method is used for increasing the friction strength of toothpaste, the chemical method is used for acid etching of a stain layer or direct peroxide bleaching and the biological enzyme method is used for digesting the stain layer, wherein the first two methods are more obvious in clinical curative effect, particularly the chemical method is optimal in clinical effect expression, the most references are made, and the enzyme method effect and the technical maturity of the latter method are not enough. However, the existing most effective chemical whitening toothpaste removes part of acquired stain films, and even locally and deeply causes corrosion influence on the glaze surface of teeth to form a new rough surface with free radicals and holes.
Disclosure of Invention
The invention aims to provide a dihydromyricetin-containing tooth whitening and repairing toothpaste and a preparation method thereof, and aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
the tooth whitening and repairing toothpaste containing dihydromyricetin comprises 0.01-5 wt% of dihydromyricetin with the purity of more than 98%, 0.1-4 wt% of sodium phytate, β -1, 3-glucan 0.01-5 wt%, 0.1-0.5 wt% of dipotassium glycyrrhizinate, 0.3-1 wt% of zinc citrate, 0-40 wt% of toothpaste friction agent, 0.2-4 wt% of adhesive thickener, 10-80 wt% of humectant, 1-4 wt% of foaming agent and 1-10 wt% of other substances.
As a still further scheme of the invention: the preparation method of the tooth whitening and repairing toothpaste comprises the following steps:
s1, adding purified water into a pre-dissolving pot, adding water-soluble raw materials such as dihydromyricetin, sodium phytate, β -1,3 glucan, dipotassium glycyrrhizinate, zinc citrate and the like into the pre-dissolving pot, stirring the solution in the pre-dissolving pot at the rotating speed of 1000r/min-1500r/min, and stirring the mixed solution to form an aqueous solution for later use;
s2: adding toothpaste friction agent into the pre-mixing powder pot, stirring at a rotation speed of 1000-1500 r/min, and uniformly dispersing to obtain powder for later use;
s3: pumping the humectant into a pre-dispersion pot, stirring at the rotating speed of 1000r/min-1200r/min, dispersing the adhesive thickener into the pre-dispersion pot, and uniformly dispersing;
s4: opening the vacuum paste making machine, starting a scraper plate for stirring, controlling the rotating speed to be 900r/min-1200r/min, pumping the materials dispersed in the steps S1 and S3 into the vacuum paste making machine through a pump, opening a homogenizer, uniformly mixing, increasing the vacuum degree in the vacuum paste making machine to-0.0940 MPa, and removing air bubbles in the vacuum paste making machine;
s5: sucking the powder material obtained in the step S2 into a vacuum paste making machine under the vacuum condition maintained in the step S4, homogenizing, grinding and uniformly stirring;
s6, opening a jacket, introducing condensed water into the vacuum paste making machine for cooling, cooling to 40 ℃, adding a foaming agent into the vacuum paste making machine, stirring at a medium speed to be homogeneous, sucking other substances, and stirring;
s7: and (3) closing the homogenizer, the stirrer and the scraper in sequence, returning the pressure to normal pressure, sampling and detecting the paste to be qualified, and filling to obtain the tooth whitening and repairing toothpaste.
As a still further scheme of the invention: the toothpaste abrasive is one of hydrated silica, calcium hydrophosphate dihydrate, calcium hydrophosphate, aluminum hydroxide and calcium carbonate, the thickening agent is one or more of carbomer, xanthan gum, carrageenan, sodium carboxymethylcellulose and seaweed extract, the humectant is one or more of glycerol, sorbitol, propylene glycol or polyethylene glycol 400, erythritol, mannitol and xylitol, the sweetening agent is at least one of saccharin and sucralose, and the foaming agent is one or more of sodium dodecyl sulfate, cocamidopropyl betaine or sodium lauroyl sarcosinate.
As a still further scheme of the invention: the other substances comprise other active substances, sweetening agents, essence, preservatives and pigment, wherein the essence is mint essence, and the pigment is allowed by toothpaste regulations.
As a still further scheme of the invention: and the stirring speed in the step S6 is 800r/min-1000 r/min.
As a still further scheme of the invention: the stirring time for adding the foaming agent in the step S6 is 10min-15min, and the stirring time for adding other substances in the step S6 is 5min-10 min.
Compared with the prior art, the invention has the beneficial effects that:
1. the toothpaste containing the dihydromyricetin and the sodium phytate has good stain removing, cleaning and whitening capacity and a gum and tooth repairing function, the sodium phytate is dissolved and desquamated through chelation, tartar is stripped through acid etching, the antioxidation of the toothpaste is definitely improved after the dihydromyricetin is compounded, the phytic acid chelating and descaling function is improved, simultaneously, the removal effect on peroxide residues and free radicals generated by oxidation and acid etching methods is realized, new surface charges after stains and tartar films are quickly repaired and removed, the normal balance of the tooth surface is kept, harmful flora is inhibited, secondary dyeing factors of external pigments such as diet and the like are avoided, the influence on the oral microenvironment and the optimal proportion of the sodium phytate are reduced, the sodium phytate and the dihydromyricetin can realize a synergistic effect, the whitening effect is consolidated, and a peculiar effect is generated.
2. The preparation method of the toothpaste has the advantages of simple process, uniform and stable paste and easy industrialization.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
a tooth whitening and repairing toothpaste containing dihydromyricetin comprises 0.1 wt% of dihydromyricetin with purity of more than 98%, 2 wt% of sodium phytate, β -1, 3-dextran 0.02 wt%, 0.2 wt% of dipotassium glycyrrhizinate, 0.3 wt% of zinc citrate, 30 wt% of toothpaste friction agent calcium carbonate, 0.6 wt% of adhesive thickening agent xanthan gum, 0.2 wt% of sodium carboxymethyl cellulose, 3 wt% of humectant glycerin, 52 wt% of sorbitol (70% aqueous solution), 2 wt% of foaming agent sodium dodecyl sulfate, 0.25 wt% of saccharin sodium, 2 wt% of preservative and essence, and the balance of pure water.
Adding purified water into a pre-dissolving pot, adding water-soluble raw materials such as dihydromyricetin and sodium phytate into the pre-dissolving pot, and stirring the mixed solution to form an aqueous solution; adding toothpaste friction agent into the premixing powder boiler, and uniformly dispersing to obtain powder; pumping the humectant into a pre-dispersing pot, dispersing the adhesive thickener into the pre-dispersing pot, adding the materials into a vacuum paste making machine, homogenizing, grinding and stirring uniformly, cooling, adding a foaming agent, essence and a preservative into the vacuum paste making machine, stirring at a medium speed to homogenize, sucking other substances, stirring, sampling and detecting the paste to be qualified, and filling to obtain the tooth whitening and repairing toothpaste.
Example two:
a tooth whitening and repairing toothpaste containing dihydromyricetin comprises 0.03 wt% of dihydromyricetin with purity of more than 98%, 2 wt% of sodium phytate, β -1, 3-dextran 0.04 wt%, 0.3 wt% of dipotassium glycyrrhizinate, 0.5 wt% of zinc citrate, 25 wt% of toothpaste abradant calcium dihydrogen phosphate, 7 wt% of hydrated silica, 0.7 wt% of adhesive thickener xanthan gum, 0.3 wt% of seaweed extract, 2 wt% of humectant glycerin, 48 wt% of sorbitol (70% of water solution), 2 wt% of foaming agent sodium dodecyl sulfate, 0.25 wt% of saccharin sodium, 0.2 wt% of paeonol, 2 wt% of preservative and essence, and the balance of pure water.
Adding purified water into a pre-dissolving pot, adding water-soluble raw materials such as dihydromyricetin and sodium phytate into the pre-dissolving pot, and stirring the mixed solution to form an aqueous solution; adding toothpaste friction agent into the premixing powder boiler, and uniformly dispersing to obtain powder; pumping the humectant into a pre-dispersing pot, dispersing the adhesive thickener into the pre-dispersing pot, adding the materials into a vacuum paste making machine, homogenizing, grinding and stirring uniformly, cooling, adding a foaming agent, essence and a preservative into the vacuum paste making machine, stirring at a medium speed to homogenize, sucking other substances, stirring, sampling and detecting the paste to be qualified, and filling to obtain the tooth whitening and repairing toothpaste.
Example three:
a tooth whitening and repairing toothpaste containing dihydromyricetin comprises 0.2 wt% of dihydromyricetin with the purity of more than 98%, 3 wt% of sodium phytate, β -1, 3-dextran 0.02 wt%, 0.2 wt% of dipotassium glycyrrhizinate, 0.3 wt% of zinc citrate, 25 wt% of toothpaste friction agent aluminum hydroxide, 5 wt% of hydrated silicon dioxide, 0.6 wt% of adhesive thickener xanthan gum, 0.2 wt% of sodium carboxymethylcellulose, 3 wt% of humectant polyethylene glycol, 50 wt% of sorbitol (70% aqueous solution), 2 wt% of foaming agent sodium dodecyl sulfate, 0.25 wt% of saccharin sodium, 2 wt% of chlorella powder, 2 wt% of preservative and essence, and the balance of pure water.
Adding purified water into a pre-dissolving pot, adding water-soluble raw materials such as dihydromyricetin and sodium phytate into the pre-dissolving pot, and stirring the mixed solution to form an aqueous solution; adding toothpaste friction agent into the premixing powder boiler, and uniformly dispersing to obtain powder; pumping the humectant into a pre-dispersing pot, dispersing the adhesive thickener into the pre-dispersing pot, adding the materials into a vacuum paste making machine, homogenizing, grinding and stirring uniformly, cooling, adding a foaming agent, essence and a preservative into the vacuum paste making machine, stirring at a medium speed to homogenize, sucking other substances, stirring, sampling and detecting the paste to be qualified, and filling to obtain the tooth whitening and repairing toothpaste.
Example four:
a tooth whitening and repairing toothpaste containing dihydromyricetin comprises 0.1 wt% of dihydromyricetin with the purity of more than 98%, 1.5 wt% of sodium phytate, β -1, 3-glucan 0.02 wt%, dipotassium glycyrrhizinate 0.2 wt%, zinc citrate 0.3 wt%, toothpaste friction agent calcium carbonate 30 wt%, adhesive thickener xanthan gum 0.6 wt%, carbomer 0.1 wt%, humectant erythritol 5 wt%, sorbitol (70% aqueous solution) 48 wt%, foaming agent sodium dodecyl sulfate 2 wt%, saccharin sodium 0.25 wt%, green tea extract 0.3 wt%, preservative and essence 2 wt%, and pure water in balance.
Adding purified water into a pre-dissolving pot, adding water-soluble raw materials such as dihydromyricetin and sodium phytate into the pre-dissolving pot, and stirring the mixed solution to form an aqueous solution; adding toothpaste friction agent into the premixing powder boiler, and uniformly dispersing to obtain powder; pumping the humectant into a pre-dispersing pot, dispersing the adhesive thickener into the pre-dispersing pot, adding the materials into a vacuum paste making machine, homogenizing, grinding and stirring uniformly, cooling, adding a foaming agent, essence and a preservative into the vacuum paste making machine, stirring at a medium speed to homogenize, sucking other substances, stirring, sampling and detecting the paste to be qualified, and filling to obtain the tooth whitening and repairing toothpaste.
Experiment I, bacteriostatic experiment
Comparing the toothpaste of the embodiment of the invention with the commercially available toothpaste, uniformly coating the toothpaste in the surface steel rings of three agar culture mediums inoculated with tested strain liquid under aseptic condition, culturing the culture dishes at the constant temperature of 37 ℃ for 24h, observing the growth condition of thalli on the surface of the membrane, and recording the radius of the inhibition zone, wherein the result is shown in table 1.
TABLE 1 antibacterial test results of toothpaste
As can be seen from the bacteriostatic circle in Table 1, the toothpaste of the invention has better bacteriostatic effect.
Second test, whitening clinical test
(1) The experimental method comprises the following steps: according to the whitening comparison experiment of the whitening repair toothpaste in the embodiment 3 of the invention and the commercially available whitening toothpaste, 2 groups are counted, 10 persons in each group are detected, the age of a tested person is 18-60 years, the allergy history and other special signs of the tested toothpaste are avoided, at least 12 complete teeth are arranged in the front of an oral cavity, and artificial teeth are avoided. The same style of toothbrush is dispensed to the subject in a unified manner. Brushing teeth in the morning and at night once, wherein the brushing teeth are carried out for three minutes each time, the diet categories in each day are kept consistent, the extrinsic stains of teeth are checked after four weeks, and the stains are checked according to the international Lobene rating method.
(2) Lobene stain area index and stain depth index
TABLE 2.4 Lobene plaque area and stain depth index results after weeks
| Toothpaste group | Area index of color spot | Index of depth of mottle |
| Commercially available whitening toothpaste | 1.80±0.33 | 1.71±0.25 |
| Example 3 | 0.57±0.18 | 0.75±0.21 |
As can be seen from Table 2, the whitening anti-inflammatory toothpaste provided by the invention has the advantages that the tooth stains and the depth of the stains are remarkably improved after four weeks of use, and the toothpaste provided by the invention can effectively remove the stains and whiten teeth.
The oral malodor removal and feeling of use were examined by sensory and air-bubble values according to the 5-point scale method, and the average values are shown in table 3 below.
TABLE 3
| Examination item | Commercially available whitening toothpaste | Examples of the invention |
| Eliminating halitosis | 3.6 | 4.9 |
| Feeling of use | 4.7 | 4.7 |
| Rate of bubbles | 4.6 | 4.5 |
Very good 5, good 4, generally 3, poor 2, very poor 1
As shown in Table 3, it is understood from the above experimental example 2 that the toothpaste of the present invention is also excellent in other feeling of use.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes, modifications, equivalents, improvements and the like can be made therein without departing from the spirit and scope of the invention.
Claims (6)
1. The tooth whitening and repairing toothpaste containing dihydromyricetin is characterized by comprising 0.01-5 wt% of dihydromyricetin with the purity of more than 98%, 0.1-4 wt% of sodium phytate, β -1, 3-glucan, 0.01-5 wt% of dipotassium glycyrrhizinate, 0.3-1 wt% of zinc citrate, 0-40 wt% of toothpaste abradant, 0.2-4 wt% of adhesive thickener, 10-80 wt% of humectant, 1-4 wt% of foaming agent and 1-10 wt% of other substances.
2. The tooth whitening and repairing toothpaste containing dihydromyricetin and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: the preparation method of the tooth whitening and repairing toothpaste comprises the following steps:
s1, adding purified water into a pre-dissolving pot, adding water-soluble raw materials such as dihydromyricetin, sodium phytate, β -1,3 glucan, dipotassium glycyrrhizinate, zinc citrate and the like into the pre-dissolving pot, stirring the solution in the pre-dissolving pot at the rotating speed of 1000r/min-1500r/min, and stirring the mixed solution to form an aqueous solution for later use;
s2: adding toothpaste friction agent into the pre-mixing powder pot, stirring at 1000-1500 r/min, and dispersing to obtain powder;
s3: pumping the humectant into a pre-dispersion pot, stirring at a rotating speed of 1000r/min-1200r/min, dispersing the adhesive thickener into the pre-dispersion pot, and uniformly dispersing;
s4: opening the vacuum paste making machine, starting a scraper plate for stirring, controlling the rotating speed to be 900r/min-1200r/min, pumping the materials dispersed in the steps S1 and S3 into the vacuum paste making machine through a pump, opening a homogenizer, uniformly mixing, increasing the vacuum degree in the vacuum paste making machine to-0.0940 MPa, and removing air bubbles in the vacuum paste making machine;
s5: sucking the powder material obtained in the step S2 into a vacuum paste making machine under the vacuum condition maintained in the step S4, homogenizing, grinding and uniformly stirring;
s6, opening a jacket, introducing condensed water into the vacuum paste making machine for cooling, cooling to 40 ℃, adding a foaming agent into the vacuum paste making machine, stirring at a medium speed to be homogeneous, sucking other substances, and stirring;
s7: and (3) closing the homogenizer, the stirrer and the scraper in sequence, returning the pressure to normal pressure, sampling and detecting the paste to be qualified, and filling to obtain the tooth whitening and repairing toothpaste.
3. The tooth whitening and repairing toothpaste containing dihydromyricetin and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: the toothpaste abrasive is one of hydrated silica, calcium hydrophosphate dihydrate, calcium hydrophosphate, aluminum hydroxide and calcium carbonate, the thickening agent is one or more of carbomer, xanthan gum, carrageenan, sodium carboxymethylcellulose and seaweed extract, the humectant is one or more of glycerol, sorbitol, propylene glycol or polyethylene glycol 400, erythritol, mannitol and xylitol, the sweetening agent is at least one of saccharin and sucralose, and the foaming agent is one or more of sodium dodecyl sulfate, cocamidopropyl betaine or sodium lauroyl sarcosinate.
4. The tooth whitening and repairing toothpaste containing dihydromyricetin and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: the other substances comprise other active substances, sweetening agents, essence, preservatives and pigment, wherein the essence is mint essence, and the pigment is allowed by toothpaste regulations.
5. The tooth whitening and repairing toothpaste containing dihydromyricetin and the preparation method thereof according to claim 2, wherein the preparation method comprises the following steps: and the stirring speed in the step S6 is 800r/min-1000 r/min.
6. The tooth whitening and repairing toothpaste containing dihydromyricetin and the preparation method thereof according to claim 2, wherein the preparation method comprises the following steps: the stirring time for adding the foaming agent in the step S6 is 10min-15min, and the stirring time for adding other substances in the step S6 is 5min-10 min.
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| CN111686036A (en) * | 2020-08-03 | 2020-09-22 | 广州市美如初化妆品有限公司 | Toothpaste for relieving gingival red swelling, bleeding and pain and preparation process thereof |
| CN113749983A (en) * | 2021-09-10 | 2021-12-07 | 淮安纵横生物科技有限公司淮阴分公司 | Volume-production anhydrous toothpaste |
| CN115708806A (en) * | 2022-10-22 | 2023-02-24 | 中国人民解放军空军军医大学 | Nanometer micelle type dihydromyricetin antibacterial agent and preparation method thereof |
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| CN115708806A (en) * | 2022-10-22 | 2023-02-24 | 中国人民解放军空军军医大学 | Nanometer micelle type dihydromyricetin antibacterial agent and preparation method thereof |
| CN115708806B (en) * | 2022-10-22 | 2024-02-13 | 中国人民解放军空军军医大学 | Nano micelle type dihydromyricetin antibacterial agent and preparation method thereof |
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Application publication date: 20200218 |