JP2000281549A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a dentifrice composition excellent in teeth-cleaning power, and excellent in an appearance and aspect stability with the elapse of time. SOLUTION: In this dentifrice composition containing one, two or more kinds of compounds selected from a straight-chain polyphosphoric acid salt expressed by the formula: Mn+2PnO3n+1 [M is Na or K; (n) is 2 or more] and a cyclic polyphosphoric acid salt expressed by the formula: (MPO3)m [M is Na or K; (m) is 3 or more], together with a lower alcohol having 3 or less carbon atoms and a water-insoluble abrasive agent which does not release calcium ion, the characteristic comprises formulating one, two or more kinds of compounds selected from a hydroxyalkylcellulose, an alginic acid salt and a carboxyvinyl polymer as bonding agents.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice composition which has an excellent tooth cleaning effect and which has improved appearance and stability over time.

[0002]

2. Description of the Related Art Conventionally, various cleaning methods have been studied to remove coloring substances (stain) such as tobacco tar and tea astringent adhered to teeth. Brushing with a dentifrice and a toothbrush containing a chemical cleaning component such as a chelating agent, polyethylene glycol, and a specific fragrance component is simple, efficient, and efficient due to the synergistic action of physical cleaning and chemical cleaning. It is possible to remove stains on the teeth.

Various components have been proposed as components for chemically removing dental stains as described below. U.S. Pat. No. 3,988,433: An oral composition containing a specific organic peroxide. U.S. Pat. No. 4,183,916: An oral composition using a cationic surfactant and malic acid in combination. JP-B-48-43869: An oral composition containing an ester having an aromatic ring. JP-A-51-139939: An oral composition containing a chelating agent having a stability coefficient of Fe> Ca. JP-A-56-18911: An oral composition using a combination of phytic acid and an organic acid. JP-A-60-4117: Oral composition containing tartronic acid, glyceric acid, hydroxy-n-butyric acid or dihydroxymalonic acid. JP-A-61-286315: Composition for oral cavity using carvone, anethole or 3-octanol in combination with a solvent extract of Astragalus plants. JP-A-62-151498: Oral composition containing 2-octanol. JP-A-62-181212: An oral composition containing a specific monoterpene. JP-A-62-189233: An oral composition containing an aliphatic ester having a total of 7 to 11 carbon atoms. Above all, water-soluble polyphosphates such as pyrophosphate and tripolyphosphate have been attracting attention for a long time as components capable of removing coloring matters of teeth without damaging the teeth, and the following proposals have been made conventionally. . JP-A-52-108029: An oral composition using a combination of a polyphosphate and a polyvalent metal cation. JP-A-1-250312: An oral composition containing an aldehyde compound having 7 to 9 carbon atoms and a polyphosphate. Japanese Patent Application Laid-Open No. 7-10726: An oral composition without an abrasive, which comprises a combination of a citrate, a water-soluble polyphosphate and a nonionic surfactant having an HLB of 7-14. JP-A-9-12437: A composition for oral cavity which uses a combination of a polyphosphate, an orthophosphate and an amphoteric surfactant to chemically clean dental stains. Japanese Patent Application Laid-Open No. 9-12438: A composition for oral cavity which uses a combination of a polyphosphate, an orthophosphate and an alkyl sulfate to chemically clean dental stains. Japanese Patent Application Laid-Open No. 9-175966: A composition for oral cavity which uses a combination of pyrophosphate and polyphosphate (P ≧ 3) to chemically clean teeth. Japanese Patent Application Publication No. 9-501679: A composition for whitening teeth using a sequestering agent (tripolyphosphate) and a reducing agent (vitamin C) in combination. Japanese Patent Publication No. Hei 9-507481: A tooth whitening composition containing 5 to 15% by weight of a water-soluble alkali metal tripolyphosphate. Japanese Patent Application Laid-Open No. 10-182386: A composition for oral cavity which uses a combination of polyphosphate and water-insoluble scrub particles derived from animals and plants to chemically clean dental stains.

However, in some cases, the polyphosphate alone or the method proposed above cannot sufficiently remove the stain attached to the tooth surface in a short time.

Accordingly, the present invention provides a dentifrice composition which is excellent in tooth cleaning action, has a high stain removal effect, and has high appearance and stability over time.

[0006]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted various studies in order to achieve the above object, and the stain removal function of the water-soluble polyphosphate has been developed by dissolving stain from the surface layer, polishing, Or, in addition to the effect of decolorization and removal, by penetrating and penetrating the polyphosphate into the stain and reaching the enamel of the tooth surface layer, the bond between the stain and the enamel is weakened, and a higher removal effect can be exhibited. As a result of focusing on and examining the results, the use of an abrasive, a lower alcohol having 3 or less carbon atoms, preferably an anionic surfactant, promotes the penetration and permeation of the polyphosphate into stains. In order to obtain a dentifrice having a high cleaning effect, the water-soluble polyphosphate, a lower alcohol having 3 or less carbon atoms, and a water-insoluble abrasive which does not release calcium ions are required. Agent was blended, more preferably have found that it is sufficient combination of anionic surfactant. However, in a dentifrice simultaneously formulated with a water-soluble polyphosphate, a lower alcohol having 3 or less carbon atoms, and a water-insoluble abrasive that does not release calcium ions, the thickening and gelling of a general-purpose binder become insufficient, In some cases, the appearance during manufacturing and long-term storage tests may impair the appearance of the skin, such as skin roughness and liquid separation.

Here, the abrasive is an essential component of a dentifrice for the purpose of whitening cleaning, and an anionic surfactant represented by sodium lauryl sulfate is also a general-purpose component of the dentifrice.
On the other hand, as a lower alcohol having 3 or less carbon atoms, ethyl alcohol is widely used.
Japanese Patent Application Laid-Open No. 6-3364 discloses a stain removing agent.
No. 16 proposes a compounding of a dentifrice composition as a component that enhances the flavor and imparts a unique flavor. JP-A-6-336416 discloses a dentifrice containing ethyl alcohol, a polyphosphate and polyethylene glycol, using a carboxymethylcellulose sodium having a specific degree of etherification as a binder to improve appearance and aging. A dentifrice composition having excellent stability has also been proposed.

[0008] However, when the content of polyphosphate and ethyl alcohol is high or when polyethylene glycol is not contained, even the proposed sodium carboxymethylcellulose does not sufficiently thicken and gel, and has a more stable appearance. It has been desired to study a binder for providing a dentifrice composition excellent in quality.

[0009] Therefore, the present inventors have formulated a water-soluble polyphosphate, a lower alcohol having 3 or less carbon atoms, and a water-insoluble abrasive which does not release calcium ions, and more preferably, a combined use of an anionic surfactant. As a result of intensive examinations to obtain a dentifrice composition that does not impair the appearance such as shape retention, rough skin, and liquid separation even when it is stored at a high temperature for a long period of time, while being excellent in cleaning power for coloring stains on teeth, A) Linear water-soluble polyphosphoric acid represented by the general formula (1): M _{n + 2} P _n O _{3n + 1} (1) (where M represents Na or K and n ≧ 2) A salt or one selected from cyclic water-soluble polyphosphates represented by the general formula (2) (MPO ₃ ) _m (2) (where M represents Na or K and m ≧ 3) or Two or more, and (B) one of lower alcohols having 3 or less carbon atoms
In a dentifrice composition comprising a seed or two or more kinds thereof and (C) a water-insoluble abrasive which does not release calcium ions, and more preferably (E) an anionic surfactant is used in combination.
(D) By blending one or more binders selected from hydroxyalkylcellulose, alginates and carboxyvinyl polymers as binders, the composition retains its shape and has rough skin even after long-term storage at high temperature. It has been found that the appearance such as liquid separation is not impaired, and the present invention has been accomplished.

Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention comprises (A) a water-soluble polyphosphate, (B) a lower alcohol having 3 or less carbon atoms, and (C) water which does not release calcium ions. Along with the insoluble abrasive,
(D) one or two of a hydroxyalkyl cellulose, an alginate and a carboxyvinyl polymer as a binder;
A mixture of more than one species.

The water-soluble polyphosphate of the component (A) blended in the above composition is represented by the following general formula (1): M _{n + 2} P _n O _{3n + 1} (1) (where M is Na or K And n ≧ 2), that is, sodium pyrophosphate or potassium pyrophosphate having a polymerization degree of n = 2, sodium tripolyphosphate or potassium tripolyphosphate having n = 3, sodium tetrapolyphosphate having n = 4, Linear polyphosphates such as potassium tetrapolyphosphate, high polymerization degree sodium metaphosphate and potassium metaphosphate, and the general formula (2) (MPO ₃ ) _m (2) (where M represents Na or K , M ≧ 3), that is, sodium or potassium trimetaphosphate having a polymerization degree of m = 3, sodium or potassium tetrametaphosphate having m = 4, = 6 cyclic polyphosphate, such as sodium hexametaphosphate and potassium hexametaphosphate is used. These polyphosphates may be used alone or in combination of two or more. Among them, linear polyphosphates are preferable, and those having a polymerization degree of 2 ≦ n ≦ 50 are more preferable. It is suitable.

In this case, the amount of the polyphosphate is as follows:
It is desirably 0.1 to 15% (wt%, the same applies hereinafter), desirably 0.2 to 10%, particularly desirably 0.3 to 8% in the composition. If it is less than 0.1%, the effect of removing dirt is not sufficiently exhibited, and if it is more than 15%, it may not be uniformly dissolved in the preparation or may have an unpleasant flavor.

As the lower alcohol having 3 or less carbon atoms of the component (B) used in combination with the polyphosphate, methyl alcohol, ethyl alcohol and propyl alcohol are used, and preferably one of ethyl alcohol and propyl alcohol is used. Alternatively, two or more types are suitably used.

The amount of the lower alcohol is preferably 1 to 30%, more preferably 1 to 20% in the composition. 1%
If the amount is less, the effect of penetrating the polyphosphate into the stain is weak, and the effect of removing dirt is not sufficiently exhibited. If the amount is more than 30%, the polyphosphate cannot be dissolved, and the preparation becomes uneven or uncomfortable. May cause sensation or irritation to mucous membranes.

In the present invention, in order not to impair the chelating effect of the polyphosphate, it is necessary to use an abrasive which does not elute calcium ions as the component (C). Such abrasives include silicic anhydride, aluminum silicate,
Examples thereof include zirconium silicate, insoluble sodium metaphosphate, bentonite, aluminum hydroxide, alumina, titanium oxide, crystalline cellulose, polymethyl methacrylate, and other synthetic resins, and it is particularly preferable to use silicic anhydride. These abrasives can be used alone or in combination of two or more, and two to two in the dentifrice composition.
70%, more preferably 5 to 50% may be blended. If the amount of the abrasive is less than 2%, the effect of cleaning dirt cannot be sufficiently exerted. If the amount is more than 70%, teeth may be scraped or scratched.

Further, in the present invention, one or more of hydroxyalkyl cellulose, alginate and carboxyvinyl polymer are blended as a binder of the component (D).

Here, as the hydroxyalkylcellulose, hydroxyethylcellulose and hydroxypropylcellulose are effectively used, and among these, the average addition mole number of ethylene oxide is 1.3 to 2.
More preferably, use is made of hydroxyalkylcellulose 5, especially hydroxyethylcellulose. This is used in an amount of 0.01 to 15%, especially 0.1 to 10%, of the whole composition.
By blending, the stability of the composition is improved satisfactorily. If the average number of moles of these hydroxyalkyl cellulose is less than the above range, it may deteriorate the skin, and if it exceeds the above range, the moldability is reduced,
Spinnability may occur. In addition, the blending amount is 0.01%
If the amount is less than 15%, the effect as a binder cannot be exhibited.
If the amount is larger than the above range, the composition may not be completely dissolved in the composition and the preparation may be non-uniform, or the preparation may be hard and difficult to come out of the tube.

Examples of the alginate include sodium alginate and potassium alginate having a cation that does not elute calcium, and sodium alginate is particularly preferred. The stability of the composition can be satisfactorily improved by adding 0.01 to 15%, especially 0.1 to 10%, of the alginate in the whole composition. If the amount of alginate is less than 0.01%, the effect as a binder cannot be exhibited, and if it is more than 15%, it does not dissolve in the composition and the formulation becomes non-uniform or the formulation becomes hard and the tube becomes hard. It may be difficult to get out.

As the carboxyvinyl polymer, a copolymer with a small amount of allyl sucrose, mainly acrylic acid, is desirable. In particular, a 0.2% aqueous solution neutralized with NaOH has a viscosity of 2,000 to 100,000 cps ( (25 ° C.) is preferred. Examples of these include: F. Goo
drich Chemical Co. , Clevel
and Carbopo, developed at Ohio, USA
1934, 940, 941, and Hibiswako 103, 104, 105, 304, 2 of Wako Pure Chemical Industries, Ltd.
Commercially available products such as No. 04 are available, but the carboxyvinyl polymer used in the present invention is not limited to these products. The compounding amount of these carboxyvinyl polymers is 0.02 to 12% in the whole composition, particularly 0.2 to 1%.
By adding 0%, the stability of the composition is improved satisfactorily. 0.02% of carboxyvinyl polymer
If less, the effect as a binder cannot be exhibited, and 12%
If the amount is more than the above, an unpleasant taste may be felt, and the preparation may become hard and difficult to come out of the tube.

When silicic anhydride is used as the polishing agent, hydroxyethyl cellulose alone or a combination of hydroxyethyl cellulose and sodium alginate as a binder has no spinnability, has good moldability, has good kneading texture, and is unpleasant. It is more preferable because there is no unpleasant sensation such as off-flavor, stickiness and stickiness. The compounding ratio is such that the weight ratio of hydroxyethyl cellulose to sodium alginate is 10: 0 to 1: 1.
0, more preferably 9: 1 to 2: 8. If the ratio of hydroxyethylcellulose to sodium alginate is less than 1:10, the paste becomes brittle, the feeling of use is reduced, and in a composition having a high concentration of polyphosphate or lower alcohol, when stored at a high temperature for a long period of time, There may be a case where the appearance quality such as separation is deteriorated.

In addition, the dentifrice composition of the present invention contains a polyphosphate to enhance the stain penetration and the cleaning effect.
It is more desirable to use an anionic surfactant in combination as the component (E). In this case, examples of the anionic surfactant include sodium alkyl sulfate such as sodium lauryl sulfate, sodium myristyl sulfate and sodium cetyl sulfate, sodium N-acyl glutamate such as sodium N-lauroyl glutamate and sodium N-palmitoyl glutamate, and N-lauroyl sarcosine. N, such as sodium and N-myristoyl sarcosine sodium
Sodium N-methyl-N-acyltaurine, sodium N-methyl-N-acylalanine, such as sodium acylsarcosine, sodium N-lauroylmethyltaurine, sodium N-myristoylmethyltaurine,
Sodium laurylbenzenesulfonate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium lauryl POE sulfate, sodium lauryl POE acetate, sodium lauryl POE phosphate, sodium stearyl POE phosphate, etc. Used.

In this case, sodium alkyl sulfate, sodium N-acylglutamate, sodium N-acylsarcosine, sodium N-methyl-N-acyltaurine, and sodium N-methyl-N-acylalanine are preferably used.

The amount of the anionic surfactant is preferably 0.3 to 10%, more preferably 0.5 to 5% in the composition. If it is less than 0.3%, the effect of penetrating the polyphosphate into the stain is weak, and the effect of removing dirt cannot be sufficiently exhibited. If it is more than 10%, unpleasant feeling of use or irritation to the mucous membrane may be felt.

Further, the dentifrice composition of the present invention may further contain, in addition to the above-mentioned components, appropriate components in accordance with the purpose, the type of the composition, etc., to form a paste, gel, liquid,
It can be in the form of a foam or the like.

For example, the above-mentioned hydroxyalkylcellulose may be used as a binder in order to improve the feeling in use in the mouth.
Other gelling agents can be used in addition to alginate and carboxyvinyl polymer. In this case, as the gelling agent, sodium carboxymethylcellulose, cellulose derivatives such as methylcellulose, carrageenan,
Gums such as xanthan gum, tragacanth gum, karaya gum, gum arabic, gellan gum, native gellan gum, synthetic binders such as polyvinyl alcohol, polyvinylpyrrolidone and polyethylene oxide; inorganic binders such as silica gel, aluminum silica gel, veegum, laponite, Species or two or more species may be blended.

Further, in the production of a paste, liquid or foam dentifrice composition, sorbit, glycerin, ethylene glycol, propylene glycol,
One or more of 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol and the like may be blended (blending amount: usually 10 to 70% in the case of toothpaste).

As the surfactant, one or two or more of nonionic surfactants and amphoteric surfactants can be used in addition to anionic surfactants. In this case, nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate, sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, maltitol fatty acid ester, and lactitol fatty acid. Sugar alcohol fatty acid esters such as esters,
Polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, fatty acid ethanolamides such as myristic acid mono- or diethanolamide, Sorbitan fatty acid esters, polyoxyethylene higher alcohol ethers, polyoxyethylene polyoxypropylene copolymers, polyoxyethylene polyoxypropylene fatty acid esters and the like are used.

Examples of the zwitterionic surfactants include alkyldimethylaminoacetate betaines such as lauryldimethylaminoacetate betaine, and N-lauryldiaminoethylglycine and N-myristyldiaminoethylglycine.
Alkyldiaminoethylglycine, N-alkyl-N-
Carboxymethylammonium betaine, 2-alkyl-1-hydroxyethylimidazoline betaine sodium and the like are used.

Further, in the present invention, dextranase, mutanase, lysozyme, amylase, protease, bacteriolytic enzyme, enzymes such as superoxide dismutanase, sodium monofluorophosphate, potassium monofluorophosphate, etc. are used as active ingredients. Fluorine compounds such as alkali metal monofluorophosphate and sodium fluoride, polyethylene glycol, polyvinylpyrrolidone, allantoin, dihydrocholestanol, glycyrrhizic acids, glycyrrhetinic acid, ε-aminocaproic acid, tranexamic acid, bisabolol, isopropylmethylphenol, sodium chloride, Triclosan, chlorhexidine salts, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, ascorbic acid and its salts, toco Eroru, Scutellaria, Phellodendron bark, rosemary, clove, may be incorporated one or more kinds of active ingredients of the herbal extract or the like, such as time.

The dentifrice composition of the present invention includes fragrances such as menthol, anethole, carvone, peppermint oil and spearmint oil, preservatives such as benzoic acid and its sodium salt, parabens, red No. 3, red No. 104, yellow No. 4,
Dyes or coloring agents such as Blue No. 1, Green No. 3, Mica Titanium, Red Petal, etc., and sweeteners such as Saccharin Sodium, Stevioside, Glycyrrhizin, Aspartame and the like can be blended.

The pH of the dentifrice composition of the present invention is not particularly limited as long as there is no problem with safety in the oral cavity and the human body, but pH 5.5 to 9 is preferred. As a regulator, hydrochloric acid, sulfuric acid, nitric acid, citric acid,
Phosphoric acid, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium citrate, sodium hydrogen citrate, sodium phosphate, sodium hydrogen phosphate and the like may be blended.

[0032]

EFFECT OF THE INVENTION The dentifrice composition of the present invention is excellent in tooth cleaning ability, appearance and property stability over time.

[0033]

EXAMPLES The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%.

A dentifrice composition having the composition shown in Tables 1 to 4 was prepared by a conventional method, filled in a tube, a bottle, or a pump container, stored in a thermostat at 50 ° C. for one month, and then stored in the container. Appearance of dentifrice, ease of taking dentifrice out of container, moldability of dentifrice taken out of container, liquid separation, rough skin, spinnability, feeling in use in mouth (unpleasant / uncomfortable), and cleaning of teeth Each force was sensory evaluated based on the following criteria.
The results are shown in Tables 1 to 4. Appearance (evaluation of color tone and uniformity: observed in a container) ○: No discoloration, no layer separation due to settling of abrasive, etc.
Uniform condition. Δ: Slight discoloration or layer separation occurred. X: Significant discoloration or separation of the abrasive and sedimentation caused layer separation. Ease of pushing out of container (when pushed out of tube, bottle, pump container) ○: Easy to push out with normal force. Δ: Slightly difficult to extrude, requiring power. ×: Very difficult to get out of container. Moldability (when extruded from tube, bottle, pump container) ○: Moderate shape easy to put on toothbrush. Δ: Slightly difficult to put on toothbrush. X: It is difficult to put on a toothbrush. Liquid separation (when pushed out of tube, bottle, pump container) ○: No liquid seepage. Δ: Exudation of liquid was slight. X: Exudation of the liquid is large. Rough skin (when pushed out of tubes, bottles, pump containers) ○: good skin is maintained. Δ: The skin is slightly rough. ×: Skin roughness is remarkable. Spinnability (when extruded from tubes, bottles, pump containers) が: No stringiness, good kneading. Δ: There is some stringing. X: There is stringing and kneading is poor. Off-taste / Discomfort ○: No unpleasant taste or unpleasant feeling such as stickiness or stickiness. Δ: Slightly unpleasant taste, or stickiness or stickiness. ×: Unpleasant taste or strong stickiness or stickiness.

Tooth cleaning ability (tobacco stain model stain removing ability) A white hydroxyapatite chip (diameter 7 mm × height 3 m) immersed in 30% phosphoric acid for 10 minutes, washed with water and dried.
m) with 10 pieces of smoke (made by JT)
Heat at 50 ° C. for 3 hours. After cooling to room temperature, the surface of the hydroxyapatite chip was gently brushed in running water to remove weakly adhered coloring matter, and then air-dried again to obtain a sample chip. After placing 1 g of the preparation on a toothbrush and brushing the surface of the sample chip with the tobacco stain on the sample chip 200 times, the formulation attached to the surface was gently rinsed with running water and lightly wiped to determine the area of the tobacco stain remaining on the surface of the sample chip. It evaluated based on. ：: 80% or more of the tobacco stains attached at the beginning were removed. Δ: Half to less than 80% of the tobacco tar attached at the beginning was removed. ×: More than half of the tobacco stains initially attached remain.

Comprehensive Evaluation Comprehensive evaluation was performed on the basis of the following criteria based on the evaluation results of eight items of appearance, ease of extrusion, moldability, liquid separation, rough skin, spinnability, unpleasantness / uncomfortable feeling, and tooth cleaning power. Was. ◎: The results of all eight items were marked with （(particularly excellent samples). ：: Samples with 1 or 2 out of 8 items marked with △, and the rest with ○. Δ: Samples with 3 to 4 items out of 8 items, and others with Os. ×: A sample with × in at least one of the eight items, or a sample with Δ in five or more even without ×.

[0037]

[Table 1]

[0038]

[Table 2]

[0039]

[Table 3]

[0040]

[Table 4]

From the results shown in Tables 1 to 4, it was found that a dentifrice composition containing a water-soluble polyphosphate, a lower alcohol having 3 or less carbon atoms and a water-insoluble abrasive that does not release calcium ions contains hydroxyalkyl cellulose as a binder, By using one or more of alginate and carboxyvinyl polymer in combination, storage stability and feeling of use are excellent,
It was also confirmed that a dentifrice composition having excellent tooth cleaning ability was obtained.

Example 21 Toothpaste (paste) Sodium tripolyphosphate 10.0% Propyl alcohol 3.0 Hydroxyethyl cellulose 2.0 Sodium alginate 1.0 Carboxyvinyl polymer (Carbopol 940) 0.2 Silicic anhydride 20.0 Sodium lauryl sulfate 1.5 Propylene glycol 3.0 Sorbit 15.0 Triclosan 0.05 Oubaku 0.05 Tranexamic acid 0.05 Sodium benzoate 0.5 Fragrance 1.0 Saccharin sodium 0.1 Purified water Balance meter 100 %

Example 22 Toothpaste (paste) Potassium tripolyphosphate 5.0% Ethyl alcohol 0.5 Propyl alcohol 0.5 Sodium alginate 1.2 Carboxyvinyl polymer (Carbopol 934) 0.2 Aluminum hydroxide 50.0 Sodium lauryl sulfate 3.0 Propylene glycol 3.0 Sorbit 15.0 Polyoxyethylene polyoxypropylene 1.0 Glycol (EO: PO = 80: 20) Carrageenan 0.2 Sodium monofluorophosphate 0.7 Dex Stranase 0.7 Methyl paraben 0.1 Butyl paraben 0.01 Fragrance 1.0 Saccharin sodium 0.1 Purified water Balance meter 100%

Example 23 Toothpaste (paste) Sodium metaphosphate (P chain = 40) 1.0% Ethyl alcohol 20.0 Hydroxyethyl cellulose 1.5 Carboxyvinyl polymer (Carbopol 940) 1.0 Hydroxidation Aluminum 30.0 Aluminum oxide 5.0 Propylene glycol 3.0 Polyethylene glycol 3.0 Sorbit 15.0 Cetylpyridinium chloride 0.05 Fragrance 1.0 Saccharin sodium 0.1 Purified water Balance meter 100%

[Example 24] Toothpaste (paste) Potassium tripolyphosphate 4.0% Sodium metaphosphate (P chain = 14) 4.0 Sodium hexametaphosphate (cyclic) 4.0 Ethyl alcohol 0 Carboxyvinyl polymer (Carbopol 940) 1.5 Carboxyvinyl polymer (Carbopol 934) 1.5 Silicic anhydride 10.0 Titanium dioxide 5.0 Sodium lauryl sulfate 0.3 Glycerin 25.0 Sodium fluoride 0.2 Triclosan 0.05 Sodium benzoate 0.3 Methyl paraben 0.1 Butyl paraben 0.01 Fragrance 1.0 Saccharin sodium 0.1 Purified water Balance meter 100%

Example 25 Liquid Dentifrice Sodium Hexametaphosphate (Cyclic) 0.1% Ethyl Alcohol 10.0 Sodium Alginate 0.5 Silicic Anhydride 15.0 Sodium Lauryl Sulfate 1.0 N-Lauroylmethyl Taurine Sodium 5 Sorbit 10.0 Glycerin 30.0 Xanthan gum 1.0 Tranexamic acid 0.05 Fragrance 1.0 Saccharin sodium 0.1 Purified water Balance meter 100%

Example 26 Liquid Toothpaste Sodium Pyrophosphate 2.0% Potassium Pyrophosphate 2.0 Propyl Alcohol 10.0 Carboxyvinyl Polymer (Carbopol 940) 1.0 Silicic Anhydride 10.0 Sodium Lauryl Sulfate 2. 0 polyethylene glycol 5.0 glycerin 40.0 decaglyceride laurate 2.0 carrageenan 0.2 xanthan gum 0.3 sodium monofluorophosphate 0.7 methyl paraben 0.2 fragrance 1.0 sodium saccharin 0.1 purified water balance meter 100 %

Example 27 Foam Toothpaste Sodium Tripolyphosphate 1.0% Sodium Metaphosphate (P Chain = 14) 1.0 Ethyl Alcohol 5.0 Hydroxypropyl Cellulose 1.0 Silicic Anhydride 2.0 Sodium Lauryl Sulfate 4.0 N-lauroyl sarcosine sodium 3.0 N-lauroyl methyl taurine sodium 3.0 propylene glycol 3.0 sorbit 20.0 glycerin 10.0 sodium benzoate 0.3 methyl paraben 0.1 butyl paraben 0.01 fragrance 1 0.0 Saccharin sodium 0.1 Purified water Balance meter 100%

Example 28 Foam Toothpaste Potassium Pyrophosphate 0.1% Sodium Metaphosphate (P Chain = 40) 0.1 Sodium Hexametaphosphate (Cyclic) 0.1 Ethyl Alcohol 5.0 Propyl Alcohol 10.0 Hydroxy Ethylcellulose 0.7 Sodium alginate 0.3 Silicic anhydride 10.0 Sodium N-lauroylmethyltaurine 5.0 Sorbit 20.0 Xylitol 10.0 Cetylpyridinium chloride 0.05 Fragrance 1.0 Saccharin sodium 0.1 Purified water Balance meter 100%

Continued on front page F-term (reference) 4C083 AA112 AB172 AB222 AB281 AB282 AB472 AC101 AC102 AC122 AC132 AC312 AC482 AC622 AC692 AC782 AC792 AC812 AC862 AD042 AD052 AD091 AD092 AD281 AD282 AD301 AD302 AD352 AD472 CC41 DD08 DD22 DD23 EE01 EE35

Claims (1)

[Claims] 1. A linear aqueous solution represented by the general formula (1): M _{n + 2} P _n O _{3n + 1} (1) (where M represents Na or K and n ≧ 2) Is selected from cyclic polyphosphates and cyclic water-soluble polyphosphates represented by the general formula (2) (MPO ₃ ) _m (2) (where M represents Na or K, and m ≧ 3). In a dentifrice composition using one or more kinds, a lower alcohol having 3 or less carbon atoms, and a water-insoluble abrasive that does not release calcium ions, the binder is selected from hydroxyalkylcellulose, alginate, and carboxyvinyl polymer. A dentifrice composition comprising one or more of the following.