JPWO2013180019A1 - Liquid oral composition - Google Patents

Abstract

Improves stain adhesion on teeth, reduces astringency and irritation, prevents stickiness in the oral cavity after application, and has a highly clear formulation appearance that is particularly good when used in mouthwash. A liquid oral composition is provided. A liquid oral composition comprising (A) a condensed phosphate, (B) a hydroxyalkyl cellulose, (C) an acyl sarcosine salt, and (D) a nonionic surfactant.

Description

  The present invention provides a liquid oral composition having a highly clear formulation appearance, which has an improved effect of suppressing the adhesion of stains to teeth, has reduced convergence and irritation, and particularly has a good feeling after use. About.

  In oral compositions, it is known that condensed phosphoric acid has an inhibitory effect on tooth stain adhesion (Patent Document 1; JP 2000-281548 A), but particularly in a liquid oral composition. There was a need for further improvement.

  In addition, when condensed phosphoric acid is blended into an oral composition, it causes a feeling of convergence and irritation, resulting in problems in use (Patent Document 2; JP-A-10-167940, Patent Document 3; JP-A-2009-155286). ) In particular, there was a problem that the astringent feeling and irritation were strongly expressed after the mouthwash.

JP 2000-281548 A Japanese Patent Laid-Open No. 10-167940 JP 2009-155286 A JP 2007-161657 A

Therefore, in a liquid oral composition, it is difficult to give a high stain adhesion inhibitory effect while blending a condensed phosphate and maintaining a good feeling in use, and improvement of the stain adhesion inhibitory effect has been a problem.
The present invention has been made in view of the above circumstances, and the effect of inhibiting the adhesion of stains to teeth has been improved. Also, the feeling of convergence and irritation can be suppressed, and the use appearance after mouth washing is particularly good, and the formulation has a clear appearance. It aims at providing the composition for liquid oral cavity which has.

  As a result of intensive studies to achieve the above object, the present inventors have found that (B) hydroxyalkyl cellulose, (C) acyl sarcosine salt, and (D) nonionic surfactant are added to (A) condensed phosphate. When combined with a liquid oral composition, the effect of inhibiting the adhesion of stains to teeth is enhanced, the astringent feeling and irritation derived from condensed phosphoric acid is suppressed, and the oral cavity does not become sticky after application. It has been found that the feeling after use becomes good, and further, the appearance of the preparation is stably maintained over time, giving a clear appearance of the preparation.

  More specifically, in the present invention, in the liquid oral composition, (B) hydroxyalkyl cellulose and (C) acyl sarcosine salt are used in combination with (A) condensed phosphate to suppress the formation of stains on teeth. In addition to enhancing the effect of suppressing adhesion, it is possible to suppress astringency and irritation. In this case, when the components (A) and (B) are used in combination, a new problem arises that a sticky feeling remains in the oral cavity, particularly after mouth washing. However, the problem of the sticky feeling described above is obtained by adding (C) an acyl sarcosine salt. Accordingly, a liquid preparation with an improved stain adhesion suppressing effect and a good feeling of use can be obtained. Furthermore, by using together the component (B) and the component (D), a clear appearance at a high temperature can be stably maintained, and a liquid preparation with good appearance stability can be obtained.

In the oral composition, hydroxyalkyl cellulose is known as a cellulosic binder, and acyl sarcosine salt is known as an anionic surfactant. In the present invention, the liquid oral composition contains (A) component (B). The combined system of components (C) and (D) acts specifically, and can give special effects that cannot be achieved with cellulose derivatives such as sodium carboxymethylcellulose or other anionic surfactants.
Patent Document 4 (Japanese Patent Application Laid-Open No. 2007-161657) includes a dentifrice composition that is formulated with sodium lauryl sulfate and hydroxypropylmethylcellulose together with a water-soluble pyrophosphate, which improves the effect of removing tooth stains and does not cause discomfort in the oral cavity. Although proposed, this is a technique of a dentifrice composition such as toothpaste in which sodium lauryl sulfate having a high foaming property contributes to removal of tooth dirt, and is technically different from the present invention.

  Accordingly, the present invention provides a liquid oral composition comprising (A) a condensed phosphate, (B) a hydroxyalkyl cellulose, (C) an acyl sarcosine salt, and (D) a nonionic surfactant. Offer things.

  According to the present invention, the effect of suppressing the adhesion of stains to teeth is improved, the feeling of convergence and irritation are suppressed, the inside of the oral cavity after application is not sticky, and the feeling of use particularly during mouthwashing is good. In addition, it is possible to provide a liquid oral composition having a formulation appearance that is stable and has a clear formulation appearance.

  The present invention will be described in further detail below. The composition for liquid oral cavity of the present invention contains (A) a condensed phosphate, (B) a hydroxyalkyl cellulose, (C) an acyl sarcosine salt, and (D) a nonionic surfactant.

  As the condensed phosphate of the component (A), linear polyphosphoric acid such as pyrophosphoric acid, tripolyphosphoric acid, tetrapolyphosphoric acid, sodium salt or potassium salt of cyclic polyphosphoric acid such as trimetaphosphoric acid, tetrametaphosphoric acid, hexametaphosphoric acid, etc. Can be mentioned.

  Condensed phosphates can be used alone or in combination of two or more, among which sodium pyrophosphate and sodium tripolyphosphate are preferred. In particular, sodium tripolyphosphate is preferred from the viewpoint of improving the feeling of use (convergence and irritation).

  The blending amount of the condensed phosphate is preferably 0.1 to 2% (mass%, the same applies hereinafter) of the entire composition, more preferably 0.2 to 2%, and still more preferably 0.2 to 1%. . Mixing 0.1% or more is suitable for improving the stain adhesion inhibiting effect. The greater the amount, the greater the stain adhesion inhibiting effect, but 2% or less is suitable for improving the feeling of use (convergence and irritation).

  The (B) component hydroxyalkyl cellulose improves the feeling of use by suppressing the astringent feeling and irritation derived from condensed phosphoric acid, and suppresses the high temperature stability decrease derived from the (D) component, thereby contributing to the appearance stability. As the hydroxyalkyl cellulose, those having an alkyl group having 2 or 3 carbon atoms are preferable, and specific examples thereof include hydroxyethyl cellulose and hydroxypropyl cellulose. In particular, hydroxyethyl cellulose is preferred from the viewpoints of suppressing the feeling of convergence and irritation derived from condensed phosphoric acid and improving the feeling of use, and the appearance stability.

The hydroxyalkyl cellulose as the component (B) is not particularly limited as long as it is used for a liquid oral preparation. For example, as hydroxyethyl cellulose, a 1% aqueous solution having a viscosity of 500 to 6,000 mPa · s is preferable, more preferably 1,000 to 4,000 mPa · s, and still more preferably 1,000 to 3, 000 mPa · s.
Specific examples of hydroxyethyl cellulose include those sold by Daicel Chemical Industries, Ltd. under product names such as SE600, SE850, SE900, and EE820.
Hydroxypropyl cellulose preferably has a viscosity in a 2% aqueous solution of 100 to 5,000 mPa · s, more preferably 500 to 5,000 mPa · s, and still more preferably 1,000 to 4,000 mPa · s. .
Specific examples of hydroxypropylcellulose include the product name M commercially available from Nippon Soda Co., Ltd.
It is more suitable for the effect expression that a viscosity is the said range.
The viscosity value was measured with a B-type viscometer (rotor No. 3, 30 rpm, 25 ° C., measured value after 1 minute).

  The compounding amount of hydroxyalkyl cellulose is preferably 0.05 to 0.5% of the entire composition, more preferably 0.05 to 0.2%, and still more preferably 0.1 to 0.2%. It is particularly preferable to add 0.05% or more from the viewpoint of stain adhesion suppressing effect, feeling of use (condensation feeling or irritation due to condensed phosphoric acid), and appearance stability. Moreover, it is especially suitable from the point of the stickiness in an oral cavity that it is 0.5% or less.

  The acyl sarcosine salt of component (C) is preferably one having an acyl group having 10 to 18 carbon atoms, and the salt is preferably an alkali metal salt such as sodium. Specifically, N-lauroyl sarcosine sodium, myristoyl sarcosine sodium, and palmitoyl sarcosine sodium are preferable, and N-lauroyl sarcosine sodium and myristoyl sarcosine sodium are particularly preferable from the viewpoint of astringency and suppression of irritation, and N-lauroyl sarcosine sodium is particularly preferable. preferable.

  The compounding amount of the acyl sarcosine salt is preferably 0.05 to 0.5% of the total composition, more preferably 0.1 to 0.5%, and still more preferably 0.10 to 0.3%. Mixing 0.05% or more is particularly suitable for enhancing the stain adhesion suppressing effect and improving the stickiness in the oral cavity. As the blending amount increases, the stain adhesion suppressing effect increases, but 0.5% or less is particularly suitable for improving the feeling of use (convergence and irritation).

  In the present invention, the stain adhesion inhibitory effect can be enhanced by using the components (A), (B), and (C) in combination, but it is more preferable to blend these components at an appropriate ratio in order to achieve the effect. In particular, the ((B) component + (C) component) / (A) component is preferably 0.1 to 3, more preferably 0.13 to 2.17, and still more preferably 0.2. ~ 1.5. 0.1 or more is particularly suitable for further improving the stain adhesion suppressing effect and improving the feeling of use (convergence and irritation), and 3 or less is particularly suitable for suppressing stickiness. Is preferred.

  Component (D), a nonionic surfactant, contributes to improving the appearance stability of liquid formulations at high temperatures when used in combination with component (B). Nonionic surfactants include polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, Examples include polyoxyethylene sorbitan fatty acid esters. Among them, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, particularly those having an average added mole number of ethylene oxide of 40 to 100 mol are more preferable.

  The blending amount of the nonionic surfactant is preferably 0.3% or more, more preferably 0.5% or more, and further preferably 0.8% or more of the entire composition from the viewpoint of appearance stability. Moreover, from the point of use feeling (non-stickiness), it is preferable to set it as 1.5% or less of the whole composition, and 1.2% or less is more preferable. When the amount is not less than the lower limit value, for example, even when a perfume that is an oil component is blended, the appearance stability at high temperatures is good, which is preferable.

  The viscosity of the liquid oral composition of the present invention is preferably in the range of 1 to 300 mPa · s, particularly 2 to 200 mPa · s, particularly 3 to 100 mPa · s, and the use of the preparation in the oral cavity. It is more preferable in terms of feeling (fluidity of the preparation at the time of mouth washing). The viscosity was measured with a B-type viscometer (rotor No. 1, 60 rpm, 25 ° C., measured value after 1 minute).

  In addition, the pH of the liquid oral composition of the present invention is not particularly limited as long as it is in a range that does not cause problems in the oral cavity, and may be in the range of pH 5.5 to 9.0.

  The liquid oral cavity composition of the present invention is particularly suitably prepared as a liquid preparation such as a mouthwash and a liquid dentifrice. Moreover, in addition to the said component, the appropriate well-known component according to a dosage form can be mix | blended in the range which does not inhibit the effect of this invention. For example, a wetting agent, a thickening agent, a surfactant, and a sweetener, an antiseptic, a fragrance, a colorant, an active ingredient, a pH adjuster, and the like can be blended if necessary. In addition, it is preferable not to mix | blend water-insoluble powders, such as an abrasive | polishing agent which is a suspension component, from the point which makes the liquid oral composition of this invention a clear external appearance.

  Examples of the wetting agent include sugar alcohols such as sorbitol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol. These wetting agents can be blended in 2 to 20% of the total composition.

  Examples of the thickener include xanthan gum and carrageenan other than hydroxyalkyl cellulose, and the blending amount is preferably 0 to 2%.

  Optional surfactants include anionic surfactants other than acyl sarcosine salts, cationic surfactants, and amphoteric surfactants.

Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate and the like N- Examples include acyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate, and the like. The amount of the anionic surfactant other than the component (C) is preferably 0 to 0.2%, more preferably 0 to 0.1%, still more preferably 0 to 0.05% of the total composition. . It is preferable to use an anionic surfactant other than the component (C), particularly an alkyl sulfate, below the upper limit because a liquid oral composition with particularly low oral irritation can be obtained. The addition of any anionic surfactant is preferably minimized and more preferably not added.
Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. 0-5% of the whole composition is preferable, and, as for the compounding quantity of a cationic surfactant, More preferably, it is 0-3%. Examples of amphoteric surfactants include betaine acetate type and imidazoline type surfactants such as alkyldimethylaminoacetic acid betaine. The amount of amphoteric surfactant is preferably 0 to 5%, more preferably 0 to 3% of the total composition.
The blending amount of any surfactant other than these components (C) and (D) is preferably 0 to 5%, particularly preferably 0.05 to 5% of the entire composition.

Examples of sweeteners include xylitol and sodium saccharin. Examples of the preservative include benzoic acid or a salt thereof, paraoxybenzoic acid ester and the like.
As the fragrance, well-known fragrances that are usually used can be appropriately blended. For example, natural fragrances such as peppermint oil, spearmint oil, and mint oil, single fragrances such as l-menthol, carvone and anethole, and further single fragrances and natural fragrances. For example, a blended fragrance containing It is preferable to mix | blend a fragrance | flavor 1 type (s) or 2 or more types in the composition 0.000013%.
As a colorant, water-soluble pigments having high safety such as yellow No. 4, red No. 106, blue No. 1, and green No. 3 can be added.

  Active ingredients include those other than condensed phosphates, for example, nonionic fungicides such as isopropylmethylphenol, cationic fungicides such as cetylpyridinium chloride, benzethonium chloride, tranexamic acid, epsilon aminocaproic acid, glycyrrhetinic acid, glycyrrhizic acid Anti-inflammatory agents such as dextranase and mutanase, fluorides such as sodium fluoride and sodium monofluorophosphate, copper compounds such as copper gluconate and copper chlorophyllin sodium, sodium chloride, potassium nitrate, aluminum lactate and chloride Examples include inorganic salts such as zinc and zinc citrate, vitamins such as ascorbic acid and tocopherol acetate, plant extracts such as azulene, dihydrocholesterol, chlorophyll, soft extract of thyme, thyme, ogon, clove, and hamamelis It is. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

As the pH adjuster, an appropriate known pH adjuster can be used, and examples thereof include phosphoric acid, citric acid, and sodium salts thereof. As a pH adjusting agent suitable for adjusting the composition pH at 25 ° C. to 5.5 to 9.0, sodium dihydrogen phosphate and sodium monohydrogen phosphate, or a combination of citric acid and sodium citrate is preferable.
As the solvent, purified water is generally used, but a lower monohydric alcohol such as ethanol may be blended in an amount of 0 to 10%, particularly 1 to 8%, especially 3 to 7%.

  The composition of the present invention can be suitably applied by preparing a liquid preparation such as a mouthwash, and rinsing the mouth for 10 to 30 seconds, particularly 15 to 20 seconds. Furthermore, you may brush with a toothbrush.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
The liquid oral composition (mouthwash) of the composition shown in Tables 1-4 was prepared by the following method, and the following evaluation was performed using the obtained preparation as a sample. The results are shown in the table.

<Method for Preparing Oral Composition>
A solution in which an oil-soluble raw material and a nonionic surfactant are dissolved in ethanol and / or polyhydric alcohol after dissolving a water-soluble raw material (excluding nonionic surfactant) in purified water according to the composition of Tables 1 to 4. Was added with stirring to achieve uniform dissolution. A three-one motor (BL1200, manufactured by HEIDON) was used for manufacturing. The viscosity of the obtained product of the present invention was 5 to 60 mPa · s. In addition, the comparative example was prepared according to the said method.

<Evaluation method of stain adhesion inhibitory effect>
1. Preparation of tannin solution Add 5 bags of tea pack containing 10g of green tea leaves (Farmer's home-grown tea 980, made by ITO EN Co., Ltd.) to 1L of boiling distilled water, and tea tea bags (Nitto Tea Daily Club, Mitsui Norin Co., Ltd.) 5 bags (made by company) were put in and extracted overnight. Thereafter, 12 g of instant coffee (Nestlé Instant Coffee, manufactured by Nestlé Japan Co., Ltd.) was added and stirred, and the volume was increased to 1,200 mL.
2. Preparation of albumin solution 6.0 g of albumin (derived from bovine serum, pH 5.2, manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 1,200 mL of distilled water.
3. Preparation of ferric chloride solution 6.85 g of ammonium iron (III) citrate (manufactured by Kanto Chemical Co., Inc.) was dissolved in 1,200 mL of distilled water.

4). Evaluation of Stain Adhesion Suppression Effect Using Hydroxyapatite (HA) Disc Measure the initial HA chromaticity of a HA disc (APP-735; manufactured by Pentax Co., Ltd.) whose surface to be tested was polished with # 1,500 sandpaper. It measured with the color difference meter (CM2002, Konica Minolta Co., Ltd. make). Next, this HA disk was immersed in the samples shown in Tables 1 to 4 at 50 ° C. for 30 seconds, then sequentially immersed in albumin solution for 10 minutes, tannin solution for 10 minutes, and ferric chloride solution for 10 minutes, This process was repeated 12 times in total, and the chromaticity of the HA disk was measured with a colorimetric color difference meter. From the ΔE value of the L ^* a ^* b ^* color system, the stain adhesion inhibition rate was calculated by the following formula. In the formula, the control was obtained by performing a series of operations similar to the above on the HA disk whose initial chromaticity was measured using purified water instead of the sample, and measuring the chromaticity of this HA disk. The ΔE value was similarly determined by measuring with a color difference meter.

Evaluation Criteria for Stain Adhesion Suppression Effect A series of experimental operations were performed with N = 3 for each Example and Comparative Example, and the average value of the stain adhesion inhibition rate of each example was calculated, and the stain removal effect was evaluated by the following evaluation criteria did.
◎: Stain adhesion inhibition rate is 80% or more and 100% or less ○: Stain adhesion inhibition rate is 60% or more and less than 80% △: Stain adhesion inhibition rate is 30% or more and less than 60% ×: Stain adhesion inhibition rate is less than 30%

<Evaluation method of feeling of use (feeling of convergence and lack of irritation)>
Evaluate the feeling of use (no astringency or irritation) after rinsing the mouth for 30 seconds, including the 10 mL sample shown in Tables 1 to 4 in the following five stages, and the average score of the five panelists According to the following criteria, it is shown in the table with ◎, ○, Δ, ×.
Evaluation criteria for feeling of use 5: Feeling no convergence or irritation 4: Feeling little astringency or irritation 3: Slight astringency or irritation, but no problem 2: Feeling astringency or irritation a little 1 : Judgment criteria for feeling of convergence and irritation ◎: Average point 4.0 to 5.0 points ○: Average point 3.0 to less than 4.0 points △: Average point 2.0 to 3 Less than 0 point x: Average point less than 2.0 point

<Evaluation method for stickiness>
In the mouth, containing 10 mL of the sample shown in Tables 1 to 4, and evaluating the absence of stickiness in the oral cavity after rinsing the mouth for 30 seconds, the average score of the five panelists was evaluated according to the following criteria: The results are shown in the table with ◎, ○, Δ, ×.
Evaluation criteria for non-stickiness 5: No stickiness 4: Little stickiness 3: Slightly sticky but no problem 2: Stickiness 1: Strong stickiness Judgment Criteria ◎: Average point 4.0 point to 5.0 point ○: Average point 3.0 point to less than 4.0 point △: Average point 2.0 point to less than 3.0 point ×: Average point Less than 2.0

<Appearance stability evaluation method>
The samples shown in Tables 1 to 4 were filled in 80 mL of a colorless and transparent PET container having a full injection amount of 90 mL, and the determination after storage at 50 ° C. for 1 month was visually determined according to the following criteria. In addition, what was (double-circle) or (circle) was judged that it was a formulation external appearance with the appearance maintained stably and high clarity.
Nigori evaluation criteria A: There is no negligible. Even if compared with a PET container filled with purified water, no abnormality is observed.
○: Slight scratching is observed compared to a PET container filled with purified water, but there is no problem because it is a level that cannot be determined without comparison.
Δ: Slightly recognized as compared with a PET container filled with purified water,
Even if there is no comparison, a slight stain is observed. ×: A clear stain is recognized without comparison with a PET container filled with purified water, and it is so cloudy that it is difficult to see through the other side of the PET container.

The details of the raw materials used are as follows.
Sodium tripolyphosphate; sodium pyrophosphate manufactured by Taihei Chemical Industry Co., Ltd .; hydroxyethyl cellulose manufactured by Taihei Chemical Industry Co., Ltd .; manufactured by Daicel Chemical Industries, Ltd., EE820, viscosity 1,300-2,100 mPa · s (1% aqueous solution, 25 ° C)
Hydroxypropyl cellulose; manufactured by Nippon Soda Co., Ltd., H, viscosity 1,000 to 4,000 mPa · s (2% aqueous solution, 20 ° C.)
N-lauroyl sarcosine sodium; Asahi Glass Co., Ltd. Myristoyl sarcosine sodium; Taihei Chemical Industrial Co., Ltd. Palmitoyl sarcosine sodium; Taihei Chemical Industrial Co., Ltd. polyoxyethylene hydrogenated castor oil; Nippon Emulsion Co., Ltd. The numerical value in parentheses is the average added mole number of ethylene oxide.

  Moreover, the liquid oral cavity compositions of the following examples were prepared using the above-mentioned raw materials in the same manner as described above, and the stain adhesion inhibitory effect, feeling of use, stickiness and appearance stability were similarly evaluated. .

[Example 26] Mouthwash (A) sodium tripolyphosphate 0.5%
(B) Hydroxyethyl cellulose 0.15
(C) Sodium N-lauroyl sarcosine 0.15
(D) Polyoxyethylene (60) hydrogenated castor oil 0.9
Isopropylmethylphenol 0.04
ε-aminocaproic acid 0.06
Glycerin 2
Propylene glycol 4
Polyethylene glycol (400) 3
Sodium monohydrogen phosphate 0.6
Sodium dihydrogen phosphate 0.1
Methyl paraoxybenzoate 0.1
Saccharin sodium 0.01
Fragrance A 0.2
Water remaining
Total 100.0%
((B) + (C)) / (A) = 0.60

Example 27 Mouthwash (A) Sodium pyrophosphate 0.3%
(B) Hydroxyethyl cellulose 0.2
(C) Palmitoyl sarcosine sodium 0.1
(D) Polyoxyethylene (100) hydrogenated castor oil 0.5
Cetylpyridinium chloride 0.05
Tranexamic acid 0.05
Glycerin 5
Propylene glycol 4
Xylitol 2
Sodium benzoate 0.2
Sodium monohydrogen phosphate 0.7
Sodium dihydrogen phosphate 0.1
Fragrance B 0.2
Water remaining
Total 100.0%
((B) + (C)) / (A) = 1.00

Example 28 Mouthwash (A) Sodium tripolyphosphate 0.3%
(B) Hydroxypropyl cellulose 0.2
(C) Myristoyl sarcosine sodium 0.2
(D) Polyoxyethylene (60) hydrogenated castor oil 0.9
Glycerin 9
Propylene glycol 3
Xylitol 2
Sodium benzoate 0.3
Methyl paraoxybenzoate 0.1
Sodium monohydrogen phosphate 0.8
Sodium dihydrogen phosphate 0.2
Green No. 3 Trace Yellow No. 4 Trace Fragrance C 0.3
Water remaining
Total 100.0%
((B) + (C)) / (A) = 1.33

[Example 29] Mouthwash (A) Sodium pyrophosphate 0.3%
(B) Hydroxyethyl cellulose 0.1
(C) N-lauroyl sarcosine sodium 0.1
(D) Polyoxyethylene (80) hydrogenated castor oil 0.8
Glycerin 7
Propylene glycol 4
Xylitol 3
Sodium benzoate 0.5
Ethyl paraoxybenzoate 0.1
Sodium monohydrogen phosphate 0.7
Sodium dihydrogen phosphate 0.1
Red No. 106 Trace Yellow No. 4 Trace Fragrance D 0.4
Water remaining
Total 100.0%
((B) + (C)) / (A) = 0.67

[Example 30] Mouthwash (A) sodium tripolyphosphate 0.4%
(B) Hydroxyethyl cellulose 0.1
(C) Palmitoyl sarcosine sodium 0.3
(D) Polyoxyethylene (80) hydrogenated castor oil 1.2
Sodium fluoride 0.05
Glycerin 5
Propylene glycol 2
Xylitol 3
Sodium benzoate 0.3
Ethyl paraoxybenzoate 0.1
Sodium monohydrogen phosphate 0.6
Sodium dihydrogen phosphate 0.1
Blue No. 1 Trace Yellow No. 4 Trace Fragrance E 0.3
Water remaining
Total 100.0%
((B) + (C)) / (A) = 1.00

Claims (12)

  A liquid oral composition comprising (A) a condensed phosphate, (B) a hydroxyalkyl cellulose, (C) an acyl sarcosine salt, and (D) a nonionic surfactant.   The liquid oral composition according to claim 1, wherein the condensed phosphate of component (A) is sodium tripolyphosphate or sodium pyrophosphate.   The liquid oral composition according to claim 1 or 2, wherein the hydroxyalkyl cellulose as component (B) is hydroxyethyl cellulose or hydroxypropyl cellulose.   The liquid oral composition according to any one of claims 1 to 3, wherein the acyl sarcosine salt of component (C) is one or more selected from N-lauroyl sarcosine sodium, myristoyl sarcosine sodium and palmitoyl sarcosine sodium.   The component (D) nonionic surfactant is selected from polyoxyethylene fatty acid ester, sugar fatty acid ester, sugar alcohol fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester and polyoxyethylene sorbitan fatty acid ester 1 It is a seed | species or more, The composition for liquid oral cavity of any one of Claims 1-4.   The component (A) is 0.1 to 2 mass%, the component (B) is 0.05 to 0.5 mass%, the component (C) is 0.05 to 0.5 mass%, and the component (D) is 0.00. The composition for liquid oral cavity according to any one of claims 1 to 5, containing 3 to 1.5% by mass.   The (B) component + (C) component) / (A) component is 0.1-3 as mass ratio, The liquid oral cavity composition of any one of Claims 1-6.   It is a clear liquid, The composition for liquid oral cavity of any one of Claims 1-7.   The composition for liquid oral cavity according to any one of claims 1 to 8, wherein the formulation has a viscosity of 1 to 300 mPa · s.   It is a liquid dentifrice or mouthwash, The composition for liquid oral cavity of any one of Claims 1-9.   Furthermore, the liquid oral cavity composition of any one of Claims 1-10 containing 2-20 mass% of wetting agents, 0-10 mass% of ethanol, and 0.00001 1-3 mass% of fragrance | flavor.   Further, it contains 0 to 5% by mass of a surfactant selected from an anionic surfactant other than the component (C), a cationic surfactant and an amphoteric surfactant, and an anionic surfactant other than the component (C) The content of is 0 to 0.2% by mass, the content of the cationic surfactant is 0 to 5% by mass, and the content of the amphoteric surfactant is 0 to 5% by mass. The liquid oral cavity composition of any one of Claims 1.