CN104363881B - Liquid oral composition - Google Patents
Liquid oral composition Download PDFInfo
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- CN104363881B CN104363881B CN201380028694.3A CN201380028694A CN104363881B CN 104363881 B CN104363881 B CN 104363881B CN 201380028694 A CN201380028694 A CN 201380028694A CN 104363881 B CN104363881 B CN 104363881B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a kind of liquid oral composition, its tachment inhibiting effect for improving tooth stain, suppresses convergence sense and stimulates, and not tacky in the oral cavity after use, use feeling when particularly gargling is good, the formulation aesthetics with high clarity.Liquid oral composition is characterised by that it contains (A) condensed phosphate, (B) hydroxy alkyl cellulose, (C) acyl sarcosinates and (D) nonionic surface active agent.
Description
Technical field
The present invention relates to a kind of liquid oral composition, it improves the effect for suppressing the attachment of tooth stain, suppress convergence sense and
Stimulate, the use feeling after particularly gargling is good, the formulation aesthetics with high clarity.
Background technology
In composition for oral cavity, it is known that condensed phosphoric acid has tooth stain tachment inhibiting effect (patent document 1：Japan Patent
JP 2000-281548 publications).But particularly in liquid oral composition, it is desirable to which spot tachment inhibiting effect enters one
Step is improved.
Additionally, condensed phosphoric acid there is a problem in that：If allotment in composition for oral cavity, will produce convergence sense and
Stimulate, bring the discomfort (patent document 2 in use feeling：Japanese Patent Laid-Open 10-167940 publications, patent document 3：Day
This patent JP 2009-155286 publications), especially occur strong convergence sense and stimulation after gargling.
Prior art literature
Patent document
Patent document 1：Japanese Patent Laid-Open 2000-281548 publications
Patent document 2：Japanese Patent Laid-Open 10-167940 publications
Patent document 3：Japanese Patent Laid-Open 2009-155286 publications
Patent document 4：Japanese Patent Laid-Open 2007-161657 publications
The content of the invention
Problem to be addressed by invention
Therefore, in liquid oral composition, by allocating condensed phosphate, it is difficult to preferably maintaining use feeling
, there is the problem for improving spot tachment inhibiting effect in the spot tachment inhibiting effect for having assigned simultaneously.
The invention that the present invention is in view of the foregoing and makees, its object is to provide a kind of liquid oral composition, its
The tachment inhibiting effect of tooth stain is improved, is suppressed convergence sense and is stimulated, the use feeling after particularly gargling is good, with high clarity
Formulation aesthetics.
The means of solve problem
The present inventor in order to achieve the above object, carried out it is conscientious study intensively, as a result find：If in (A) contracting
Share (B) hydroxy alkyl cellulose, (C) acyl sarcosinates and (D) nonionic surface active agent and allocate in conjunction phosphate
Liquid oral composition, then improve tooth stain tachment inhibiting effect, suppresses convergence sense and stimulation from condensed phosphoric acid, after use
Not tacky in oral cavity, the use feeling after particularly gargling is good, and keeps formulation aesthetics long-term and stably, assigns clarification high
The formulation aesthetics of degree.
If further described, in the present invention, in liquid oral composition, by (A) condensed phosphate
In share (B) hydroxy alkyl cellulose and (C) acyl sarcosinates, not only suppress tooth in spot formation, enhancing suppress it is attached
The effect, additionally it is possible to suppress convergence sense and stimulate.In this case, although share (A), (B) and produced into branch and especially gargled
New problem as sticky feeling is remained in oral cavity afterwards, but by allocating (C) acyl sarcosinates, the problem of above-mentioned sticky feeling
Disappear, hereby it is possible to obtain spot tachment inhibiting effect improve and the good liquid preparation of use feeling.Further, pass through
(B) composition and (D) composition are shared, clarification outward appearance during high temperature can be stably maintained, the good liquid system of appearance stability is obtained
Agent.
In composition for oral cavity, although known hydroxy alkyl cellulose as cellulose family binding agent, acyl group methyl amimoacetic acid
During salt is as anionic surfactant, but the present invention, in liquid oral composition, (A) composition and (B), (C) and
(D) sharing for composition is specifically to play a role, can assign sodium carboxymethylcellulose etc. cellulose derivative or its
Its unavailable special action effect of anionic surfactant.
Additionally, being proposed water-soluble pyrophosphate in patent document 4 (Japanese Patent Laid-Open 2007-161657 publications)
Allocated jointly with sldium lauryl sulfate and hydroxypropyl methyl cellulose the tooth stain removal effect that obtains improve and without in oral cavity not
The Dentrifice composition of suitable sense.But the patent document is toothpaste that foaming characteristic sldium lauryl sulfate high contributes to the removal of tooth stain etc.
Dentrifice composition technology, from the present invention it is technically different.
Therefore, the present invention provides a kind of liquid oral composition, it is characterised in that contain (A) condensed phosphate, (B)
Hydroxy alkyl cellulose, (C) acyl sarcosinates and (D) nonionic surface active agent.
The effect of invention
According to the present invention, it is possible to provide following liquid oral composition：It improves the effect for suppressing the attachment of tooth stain, suppresses
Convergence sense and stimulation, not tacky in the oral cavity after use, use feeling when particularly gargling is good, and formulation aesthetics stabilization,
Formulation aesthetics with high clarity.
Specific embodiment
The present invention is illustrated in detail further below.Liquid oral composition of the invention contain (A) condensed phosphate,
(B) hydroxy alkyl cellulose, (C) acyl sarcosinates and (D) nonionic surface active agent.
As the condensed phosphate of (A) composition, the poly- phosphorus of straight-chain of pyrophosphoric acid, tripolyphosphate, four polyphosphoric acids etc. can be enumerated
The sodium salt or sylvite of the cyclic polyphosphoric acid of acid, three METHAPHOSPHORIC ACIDs, tetramethyl phosphoric acid, pregnancy phosphoric acid etc..
Condensed phosphate can independent a kind or two or more be applied in combination, wherein it is preferred that sodium pyrophosphate, sodium tripolyphosphate.
Especially, from from the viewpoint of improving use feeling (convergence sense and stimulate), preferred sodium tripolyphosphate.
The proportional quantity of condensed phosphate be preferably composition it is all 0.1~2% (quality %, similarly hereinafter.), more preferably 0.2
~2%, more preferably 0.2~1%.Raising of the allotment more than 0.1% to spot tachment inhibiting effect is suitable.Although
Proportional quantity is more, and spot tachment inhibiting effect is better, but less than 2% to be suitable to improving use feeling (convergence sense and stimulate)
's.
(B) hydroxy alkyl cellulose of composition suppresses convergence sense and stimulation from condensed phosphoric acid and improves use feeling, and
Suppress the high-temperature stability reduction from (D) composition, contribute to appearance stability.As hydroxy alkyl cellulose, preferred alkyl
Carbon number is 2 or 3 hydroxy alkyl cellulose, can specifically enumerate hydroxyethyl cellulose, hydroxypropyl cellulose.Especially,
From the convergence sense suppressed from condensed phosphoric acid and stimulate and from the viewpoint of improving the viewpoint and appearance stability of use feeling, preferably
Hydroxyethyl cellulose.
(B) as long as the hydroxy alkyl cellulose of composition in liquid oral preparation using being just not particularly limited.For example,
Used as hydroxyethyl cellulose, the viscosity of preferably 1% aqueous solution is the hydroxyethyl cellulose of 500~6000mPas, more preferably
1000~4000mPas, more preferably 1000~3000mPas.
As hydroxyethyl cellulose, specifically, can using from Daisel chemical industry Co., Ltd with SE600,
The product that the ProductName of SE850, SE900, EE820 etc. is sold.
Used as hydroxypropyl cellulose, the viscosity of preferably 2% aqueous solution is the hydroxypropyl cellulose of 100~5000mPas,
More preferably 500~5000mPas, more preferably 1000~4000mPas.
As hydroxypropyl cellulose, specifically, can use the trade name M's that is sold from Tso Tat Co., Ltd., Japan etc.
Product.
Viscosity is above range, more suitable in terms of effect embodiment.
Additionally, viscosity number is determined with Brookfield viscometer (rotor No.3,30rpm, 25 DEG C, the measured value after 1 minute).
The proportional quantity of hydroxy alkyl cellulose is preferably all 0.05~0.5%, more preferably 0.05~0.2% of composition,
More preferably 0.1~0.2%.From spot tachment inhibiting effect, use feeling (from condensed phosphoric acid convergence sense and stimulate
Whether there is) and appearance stability from the viewpoint of, allotment is 0.05% above is particularly suitable.Additionally, from intraoral tacky
From the viewpoint of, 0.5% the following is particularly suitable.
Used as the acyl sarcosinates of (C) composition, the carbon number of preferably acyl group is 10~18 acyl sarcosinates, this
Outward, as salt, the preferred alkali metal salt of sodium etc..And specifically, it is preferable to N- sodium lauroyl sarcosines, myristoyl-N-methylaminoacetic acid sodium, palm fibre
Palmitic acid acylsarcosine sodium, especially restrains from the viewpoint of feeling and stimulating, preferably N- sodium lauroyl sarcosines, myristoyl flesh from suppression
Propylhomoserin sodium, particularly preferred N- sodium lauroyl sarcosines.
The proportional quantity of acyl sarcosinates is preferably all 0.05~0.5%, more preferably 0.1~0.5% of composition, enters
One step is preferably 0.10~0.3%.Allotment more than 0.05% is for improving spot tachment inhibiting effect and improving intraoral
Sticky feeling is particularly suitable.Although proportional quantity is more, and spot tachment inhibiting effect is better, 0.5% makes below for improvement
It is particularly suitable with sense (convergence sense and stimulation).
In the present invention, spot tachment inhibiting effect can be strengthened by sharing (A), (B), (C) composition, according to appropriate ratio
It is more suitable in terms of effect embodiment that example allocates these compositions.Especially, ((B) composition+(C) composition)/(A) composition is with mass ratio
Meter, preferably 0.1~3, more preferably 0.13~2.17, more preferably 0.2~1.5.More than 0.1 for further raising
Spot tachment inhibiting effect and the use feeling that improves (convergence sense and stimulation) are particularly suitable, and 3 below for suppression sticky feeling
It is particularly suitable.
(D) nonionic surface active agent of composition is shared by with (B) composition, contributes to liquid preparation at high temperature
Appearance stability is improved.As nonionic surface active agent, the polyoxyethylene fat of Crodaret etc. can be enumerated
The sugar fatty acid ester of fat acid esters, sucrose fatty ester etc., sugar alcohol fatty acid ester, sorbitan fatty acid ester, glycerine fatty acid
Ester, polyglyceryl fatty acid ester, polyoxyethylene sorbitan fatty acid ester etc..Wherein, Crodaret etc. is poly-
Oxygen ethene fatty acid ester, it is preferably that the average additional molal quantity of special ethylene oxide is 40~100 moles.
From from the viewpoint of appearance stability, the proportional quantity of nonionic surface active agent is preferably composition entirety
More than 0.3%, more preferably more than 0.5%, more preferably more than 0.8%.Additionally, from use feeling (the presence or absence of sticky feeling)
From the viewpoint of, preferably constitute less than the 1.5% of entirety, more preferably less than 1.2%.More than above-mentioned lower limit,
Even if allocating the spices of such as oil components, the appearance stability under high temperature is also good, thus preferably.
The viscosity of liquid oral composition of the invention preferably in the scope of 1~300mPas, from intraoral preparation
From the viewpoint of use feeling (formulation flows when gargling), particularly 2~200mPas, especially 3~100mPas are more
For preferred.Additionally, viscosity is determined with Brookfield viscometer (rotor No.1,60rpm, 25 DEG C, the measured value after 1 minute).
As long as additionally, the scope that the pH of liquid oral composition of the invention has no problem in intraoral security
Inside just it is not particularly limited, can is the scope of pH5.5~9.0.
Liquid oral composition of the invention is particularly preferably modulated to the liquid preparation of collutory, liquid dentifrice etc..
Additionally, in addition to the aforementioned ingredients, the appropriate known composition corresponding to formulation can be allocated in the range of without prejudice to effect of the present invention.
Such as wetting agent, tackifier, surfactant, further as needed allotment sweetener, preservative, spices, colouring agent, effectively
Composition, pH adjusting agent etc..Additionally, from from the viewpoint of the outward appearance of clarification, liquid oral composition of the invention is preferably uncomfortable
The water-insoluble powder of the grinding agent equipped with suspended composition etc..
As wetting agent, the polyalcohol of sugar alcohol, glycerine, propane diols, the polyethylene glycol of D-sorbite etc. etc. can be enumerated.These
The 2~20% of the adjustable composition entirety of wetting agent.
As tackifier, the xanthans that can be enumerated beyond hydroxy alkyl cellulose, carragheen etc., optimum ratio amount is 0~
2%.
As arbitrary surfactant, the anionic surfactant that can be enumerated beyond acyl sarcosinates, sun from
Subtype surfactant, amphoteric surfactant.
As anionic surfactant, the alkylsurfuric acid of NaLS, myristyl sulfate etc. can be enumerated
Salt, neopelex, hydrogenated coconut oil fatty acid monoglyceride sulfate mono sodium, lauryl sulfoacetate sodium, N- palmityls
The N- acyl glutamates of sodium glutamate etc., N- methyl-N acyl methyltaurin sodium, N- methyl-N- acylalaninies sodium, α-alkenyl
Sodium sulfonate etc..The proportional quantity of the anionic surfactant beyond above-mentioned (C) composition is preferably all 0~0.2% of composition,
More preferably 0~0.1%, more preferably 0~0.05%.(C) anionic surfactant beyond composition, particularly
When alkyl sulfate is below above-mentioned higher limit, it is particularly capable of obtaining the small liquid oral composition of oral cavity internal stimulus,
Thus preferably.It is preferred that adding arbitrary anionic surfactant in Min., do not allocate more preferably.
As cationic surface active agent, alkylammonium, alkyl benzyl ammonium salt etc. can be enumerated.Cationic surface active agent
Proportional quantity be preferably all 0~5%, more preferably 0~3% of composition.As amphoteric surfactant, alkyl two can be enumerated
The acetic acid betaine type of methylamino acetic acid glycine betaine etc., the surfactant of imidazoline type.The proportioning of amphoteric surfactant
Amount is preferably and constitutes all 0~5%, more preferably 0~3%.
The proportional quantity of the arbitrary surfactant beyond these (C), (D) composition is preferably all 0~5% of composition,
Particularly 0.05~5%.
As sweetener, xylitol, saccharin sodium etc. can be enumerated.As preservative, benzoic acid or its salt can be enumerated, to hydroxyl
Benzoic ether etc..
As spices, usually used known spices can be suitably allocated, for example, can enumerate Fructus Piperis peppermint oil, spearmint
Single product spices of natural perfume material, MENTHOL, carvol, the anethole of oil, peppermint oil etc. etc. and contain single product spices, day
Mediation spices of right spices etc..Spices preferably in the composition proportioning a kind of 0.00001~3% or two or more.
As colouring agent, yellow 4, red No. 106, cyan 1, the safe water of green No. 3 etc. can be added
Dissolubility pigment.
Used as active ingredient, the composition beyond condensed phosphate can for example enumerate the nonionic of isopropyl methyl phenol etc.
The cationic bactericide of type bactericide, cetylpyridinium chloride, benzethonium chloride etc., tranexamic acid, EACA, Radix Glycyrrhizae
The fluoride of the enzyme of the antiinflammatory of hypo acid, glycyrrhizic acid etc., dextranase, change dextranase etc., sodium fluoride, sodium monofluorophosphate etc., Portugal
The copper compound of grape saccharic acid copper, sodium copper chlorophyllin etc., sodium chloride, potassium nitrate, aluctyl, zinc chloride, zinc citrate etc. it is inorganic
The vitamins of salt, ascorbic acid, D-α-tocopherol acetate etc., in azulenes, beta-cholestanol, chlorophyll, angelica extract, hundred
Plant extracts of perfume, the root of large-flowered skullcap, cloves, witch hazel etc. etc..Additionally, above-mentioned active ingredient can be in without prejudice to effect of the present invention
In the range of with effective dose allocate.
As pH adjusting agent, can use appropriate known pH adjusting agent, can for example enumerate phosphoric acid, citric acid and its
Sodium salt etc..As 25 DEG C of composition pH being adjusted to 5.5~9.0 suitable pH adjusting agent, preferably phosphoric acid sodium dihydrogen and phosphorus
Sour hydrogen sodium, or citric acid and sodium citrate combination.
As solvent, Purified Water is generally used, it is also possible to according to 0~10%, particularly 1~8%, especially 3~7%
The lower monovalent alcohols of degree allotment ethanol etc..
The particularly suitable liquid preparation for being modulated to collutory etc. of composition of the invention, keeps in the mouth and gargles 10~30 seconds,
Particularly 15~20 seconds.It is further possible to be scrubbed with toothbrush.
Embodiment
Embodiment is given below and comparative example illustrates the present invention, but the present invention is not limited by following embodiments.
Additionally, in following examples, unless otherwise instructed, % represents quality %.
[embodiment, comparative example]
The liquid oral composition (collutory) for being constituted shown in modulation table 1~4 by the following method, the preparation that will be obtained
Following evaluations are carried out as sample.Result is recorded in table together.
<The modulator approach of composition for oral cavity>
According to the composition of table 1~4, after dissolving water-soluble material (except nonionic surface active agent) in Purified Water,
It is added in while stirring in ethanol and/or polyalcohol and has dissolved the liquid of Oil soluble materials and nonionic surfactant, makes
Its uniform dissolution.Additionally, having used general agitator (BL1200, new east science Co. Ltd. system) in manufacture.This hair for obtaining
The viscosity of bright product is 5~60mPas.Additionally, modulating comparative example according to the method described above.
<The evaluation method of spot tachment inhibiting effect>
1. the modulation of tannin liquid
5 bags are put into the distilled water of 1L boilings, and comprising 10g green teas, (farmers' goes out the (Farming families of tea 980 oneself goes out certainly
Tea 980), her rattan garden Co. Ltd. system) tea bag, place into 5 bags of black tea tea bags (day east black tea Daily Club, three well agricultural
Co. Ltd. system), extract an evening.Afterwards, 12g instant coffee (nest's instant coffee, Amada Co., Ltd. of nest are added
System) stirring after, be settled to 1200mL.
2. the modulation of albumin liquid
6.0g albumin (coming from cow's serum, pH5.2, Wako Pure Chemical Industries, Ltd.'s system) is dissolved in 1200mL distillations
In water.
3. the modulation of ferric chloride solution
6.85g ferric citrates (III) (Kanto Kagaku K. K.'s system) are dissolved in 1200mL distilled water.
4. the evaluation of the spot tachment inhibiting effect of hydroxyapatite (HA) disk is used
Determined with colour examining colour-difference-metre (CM2002, Konica Minolta Opto Inc.'s system) and ground with #1500 sand paper by experiment face
The initial stage HA colourity of the HA disks (APP-735, Pentax Co., Ltd's system) of mill.Then, by the HA disks be immersed at 50 DEG C table 1~
30 seconds in sample shown in 4, it is immersed in successively afterwards 10 minutes in albumin liquid, 10 minutes in tannin liquid, in ferric chloride solution
After 10 minutes, wash with water, operate this operation to amount to repeatedly 12 times, the colourity of HA disks is determined with colour examining colour-difference-metre.By L*a*b*
The Δ E values of color specification system calculate spot tachment inhibiting rate according to following formula.Additionally, the control in formula is to replace sample with Purified Water to surveying
Obtained from having determined the HA disks of initial stage colourity and carrying out sequence of operations similar to the above, this HA disk is determined with colour examining colour-difference-metre
Colourity, similarly obtains Δ E values.
[number 1]
The metewand of spot tachment inhibiting effect
Each embodiment and comparative example carry out a series of experimental implementation according to N=3, and the spot for calculating each example is attached
The average value of inhibiting rate, evaluating spot according to following metewands removes effect.
◎：Spot tachment inhibiting rate is more than 80% and less than 100%
○：Spot tachment inhibiting rate is more than 60% and less than 80%
△：Spot tachment inhibiting rate is more than 30% and less than 60%
×：Spot tachment inhibiting rate is less than 30%
<The evaluation method of use feeling (the presence or absence of convergence sense and stimulation)>
Contain the sample shown in 10mL tables 1~4 in mouthful, the use feeling after spuing of just gargling 30 seconds (restrains what is felt and stimulate
Whether there is) according to 5 following grade evaluations, 5 average marks of reviewer exist according to following benchmark ◎, zero, △, × expression
In table.
The metewand of use feeling
5：Imperceptible convergence sense and stimulation
4：Almost imperceptible convergence sense and stimulation
3：Convergence sense is felt slightly and is stimulated, but be the degree having no problem
2：Somewhat feel convergence sense and stimulate
1：Feel convergence sense and stimulate
The determinating reference of use feeling
◎：More than 4.0 points and less than 5.0 points of average mark
○：More than 3.0 points of average mark and less than 4.0 points
△：More than 2.0 points of average mark and less than 3.0 points
×：Average mark is less than 2.0 points
<The evaluation method of sticky feeling>
Contain in mouthful the presence or absence of sample shown in 10mL tables 1~4, the intraoral sticky feeling just gargled 30 seconds after spuing by
According to 5 following grade evaluations, 5 average marks of reviewer are according to following benchmark ◎, zero, △, × expression in table.
The metewand that sticky feeling whether there is
5：There is no sticky feeling
4：Almost without sticky feeling
3：There is sticky feeling slightly, but be the degree having no problem
2：There is sticky feeling
1：There is strong sticky feeling
The determinating reference that sticky feeling whether there is
◎：More than 4.0 points and less than 5.0 points of average mark
○：More than 3.0 points of average mark and less than 4.0 points
△：More than 2.0 points of average mark and less than 3.0 points
×：Average mark is less than 2.0 points
<The evaluation method of appearance stability>
To the sample filled in the pet container of the water white transparency of the amount of filling 90mL shown in 80mL tables 1~4, in accordance with following bases
Standard visually confirm 50 DEG C preserve 1 month after muddiness.Additionally, judging ◎ or zero for the clarity for keeping outward appearance can be stablized
Formulation aesthetics high.
Muddy metewand
◎：Completely without muddiness.Even if the pet container with filling Purified Water compares, muddiness is not seen completely yet.
○：Compare with the pet container for being filled with Purified Water, can see a little muddy, but be if not comparing not
The degree that can be judged, has no problem.
△：Compare with the pet container for being filled with Purified Water, can substantially see muddiness, though do not compare also it can be seen that
It is a little muddy.
×：Even if not comparing with the pet container for being filled with Purified Water, muddiness also can be substantially seen, be to be difficult perspective PET to hold
The degree of device offside, it is muddy.
Additionally, using the detailed as follows of raw material.
Sodium tripolyphosphate；Peaceful Chemical Industries Co. Ltd. system
Sodium pyrophosphate；Peaceful Chemical Industries Co. Ltd. system
Hydroxyethyl cellulose；Daisel chemical industry Co., Ltd's system, EE820,1300~2100mPas of viscosity (1%
The aqueous solution, 25 DEG C)
Hydroxypropyl cellulose；Tso Tat Co., Ltd., Japan's system, H, 1000~4000mPas of viscosity (2% aqueous solution, 20
℃)
N- sodium lauroyl sarcosines；Asahi Glass Co., Ltd's system
Myristoyl-N-methylaminoacetic acid sodium；Peaceful Chemical Industries Co. Ltd. system
Palmitoyl sarcosine sodium；Peaceful Chemical Industries Co. Ltd. system
Crodaret；Japanese エ マ Le ジ ョ Application Co. Ltd. systems, additionally, the numerical value in () is oxidation second
The average additional molal quantity of alkene.
[table 1]
[table 2]
[table 3]
[table 4]
Additionally, the liquid oral composition of following embodiments is modulated using above-mentioned use raw material as described above, just
It is all outstanding when spot tachment inhibiting effect, use feeling, sticky feeling and appearance stability are similarly evaluated.
[embodiment 26] collutory
Claims (10)
1. liquid oral composition, it is characterized by, contain the mass % of (A) condensed phosphate 0.1~2, (B) hydroxy alkyl cellulose
The average additional molal quantity of 0.05~0.5 mass %, the mass % of (C) acyl sarcosinates 0.05~0.5 and (D) ethylene oxide
It is 40~100 moles of the mass % of Crodaret 0.3~1.5.
2. liquid oral composition as claimed in claim 1, wherein, the condensed phosphate of (A) composition is sodium tripolyphosphate
Or sodium pyrophosphate.
3. liquid oral composition as claimed in claim 1, wherein, the hydroxy alkyl cellulose of (B) composition is fine ethoxy
Dimension element or hydroxypropyl cellulose.
4. liquid oral composition as claimed in claim 1, wherein, the acyl sarcosinates of (C) composition are selected from the N- months
One or more of osmanthus acylsarcosine sodium, myristoyl-N-methylaminoacetic acid sodium and palmitoyl sarcosine sodium.
5. as Claims 1 to 4 any one described in liquid oral composition, wherein, ((B) composition+(C) composition)/
(A) composition is by quality ratio 0.1~3.
6. as Claims 1 to 4 any one described in liquid oral composition, its be clarification liquid.
7. as Claims 1 to 4 any one described in liquid oral composition, its formulation viscosity be 1~300mPa
s。
8. as Claims 1 to 4 any one described in liquid oral composition, it is liquid dentifrice or gargles
Agent.
9. as Claims 1 to 4 any one described in liquid oral composition, its further contain wetting agent 2~20
Quality %, the mass % of ethanol 0~10, the mass % of spices 0.00001~3.
10. as Claims 1 to 4 any one described in liquid oral composition, its further containing be selected from (C) composition
The surfactant 0~5 of anionic surfactant, cationic surface active agent and amphoteric surfactant in addition
Quality %, wherein, the content of the anionic surfactant beyond (C) composition is 0~0.2 mass %, cationic
The content of activating agent is 0~5 mass %, and the content of amphoteric surfactant is the scope of 0~5 mass %.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-120488 | 2012-05-28 | ||
| JP2012120488 | 2012-05-28 | ||
| PCT/JP2013/064435 WO2013180019A1 (en) | 2012-05-28 | 2013-05-24 | Liquid oral composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104363881A CN104363881A (en) | 2015-02-18 |
| CN104363881B true CN104363881B (en) | 2017-06-09 |
Family
ID=49673215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380028694.3A Active CN104363881B (en) | 2012-05-28 | 2013-05-24 | Liquid oral composition |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP6217628B2 (en) |
| KR (1) | KR101821627B1 (en) |
| CN (1) | CN104363881B (en) |
| WO (1) | WO2013180019A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6441669B2 (en) * | 2014-12-26 | 2018-12-19 | 花王株式会社 | Liquid oral composition |
| KR20180073612A (en) * | 2015-10-26 | 2018-07-02 | 콜게이트-파아므올리브캄파니 | Oral care products and methods |
| CN108289800B (en) * | 2015-12-14 | 2021-10-22 | 花王株式会社 | Liquid oral composition |
| WO2018043717A1 (en) * | 2016-09-02 | 2018-03-08 | ライオン株式会社 | Composition for oral cavity |
| JP2018052886A (en) * | 2016-09-29 | 2018-04-05 | 小林製薬株式会社 | Aqueous formulation |
| JP6939096B2 (en) * | 2017-05-31 | 2021-09-22 | ライオン株式会社 | Liquid oral composition |
| BE1025996A9 (en) * | 2018-01-19 | 2020-05-11 | Hyloris Dev Sa | ORAL TRANEXAMIC ACID SOLUTION |
| JP7245110B2 (en) * | 2018-05-15 | 2023-03-23 | アース製薬株式会社 | Liquid oral composition and oral cleaning method |
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| JPH03200714A (en) * | 1989-12-27 | 1991-09-02 | Lion Corp | Composition for oral cavity application |
| JP2980771B2 (en) * | 1992-03-17 | 1999-11-22 | サンスター株式会社 | Transparent liquid oral composition |
| JP4109727B2 (en) * | 1996-07-05 | 2008-07-02 | サンスター株式会社 | Composition for oral cavity containing amino acid surfactant |
| JP3951085B2 (en) * | 1999-03-29 | 2007-08-01 | ライオン株式会社 | Dentifrice composition |
| WO2003055459A1 (en) * | 2001-12-25 | 2003-07-10 | Kao Corporation | Composition for mouth |
| KR101181379B1 (en) * | 2003-06-27 | 2012-09-19 | 라이온 가부시키가이샤 | Dentifrice composition |
| CN101690699A (en) * | 2009-09-29 | 2010-04-07 | 广东名臣有限公司 | Teeth-cleaning whitening toothpaste composition |
| JP5576743B2 (en) | 2010-08-25 | 2014-08-20 | 花王株式会社 | Liquid oral composition |
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- 2013-05-24 KR KR1020147022359A patent/KR101821627B1/en active IP Right Grant
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| WO2013180019A1 (en) | 2013-12-05 |
| CN104363881A (en) | 2015-02-18 |
| JP6217628B2 (en) | 2017-10-25 |
| JPWO2013180019A1 (en) | 2016-01-21 |
| KR101821627B1 (en) | 2018-01-24 |
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