CN108553336A - One kind is gargled pearl and its preparation method and application - Google Patents
One kind is gargled pearl and its preparation method and application Download PDFInfo
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- CN108553336A CN108553336A CN201810322826.8A CN201810322826A CN108553336A CN 108553336 A CN108553336 A CN 108553336A CN 201810322826 A CN201810322826 A CN 201810322826A CN 108553336 A CN108553336 A CN 108553336A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/025—Explicitly spheroidal or spherical shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Abstract
The present invention relates to field of oral care, it gargles pearl and its preparation method and application more particularly to one kind, the unstable ingredient such as some active constituents, essence is prepared into the pellet for pearl of gargling by unique technique for packing, many limitations to transparent gargle are thus eliminated, ensure the stability of active constituent；The pearl that will gargle is used to prepare gargle, reaches and prevents decayed tooth, fresh breath, the effect for tooth-whitening, mitigating sensitivity of tooth, safeguarding gums healthy, has significant advantage compared with prior art.
Description
Technical field
The present invention relates to field of oral care, and in particular to one kind is gargled pearl and its preparation method and application.
Background technology
People's routine use toothpaste is brushed teeth to keep oral health, however, the mode brushed teeth can only clean oral cavity area
25% or so, also many mouth areas such as teeth space, tongue fur, the oral cavity regions Nei Hedeng cannot all be cleaned well.Therefore, exist
After after brushing, using oral cavity cleaning and nursing liquid, is conducive to further clean oral cavity, reduces oral bacteria, prevent oral problem.
Gargle in the prior art usually adds various fluorides to reach pre- antieurodontic effect, or by using anti-
Microorganism agent such as triclosan, plant extracts, quaternary ammonium compound or essential oil, pre- anti-gingivitis and periodontosis；Or by using at
Divide such as strontium chloride, stannous fluoride or potassium nitrate, mitigation sensitivity of tooth；Or by adding polyphosphate, peroxide, biological enzyme
Etc. come achieve the effect that remove calculus dentalis, tooth-whitening；Or reach removal mouth by adding essence, freshener, zinc ion etc.
It is smelly, the effect of fresh breath；Or reach removal dry by adding biological enzyme, polypeptide, high molecular polymer, plant polyphenol etc.
Effect.
In order to satisfy the use demand, using water as main component, the gargle of the existing overwhelming majority all contains gargle
70% or more water, further include one or more other solvents (such as ethyl alcohol) and surfactant, wetting agent, flavoring agent and
The additives such as sweetener.The Formula Development of this large amount of aqueous dosage forms, other than Product Safety points for attention, preparation is gargled
Oral fluid product also needs to balance many factors, including：(a) chemical stability of active component, compatibility and bioavailability, with
Reach corresponding effect；(b) fragrance and mouthfeel characteristic to provide consumer acceptability, and also encourage user to defer to weight
It is multiple to use, and retain in the oral cavity more long to provide effect；(c) negative effect during use is avoided or reduced, it such as can the energy
From the tooth discoloration of anti-microbial cationic component；And (d) physical stability of product, for the acceptable shelf-life and
Commercial viability.The generally transparent uniform liquid of gargle in the prior art, wherein all components are dissolved completely in liquid
In carrier, the liquid-carrier is water or water/solvent mixture.Because appearance transparent and homogeneous product are easy to be connect by consumer
By and it is easy to use.Better mouthfeel and fragrance in order to obtain would generally add a certain amount of essence in gargle, these essence
Including ingredients such as American mint, spearmint, wintergreens.The perfume ingredient overwhelming majority belongs to volatile oil, is generally insoluble in water, because
This, needs to increase solubilizer to form clear solution.It includes ethyl alcohol, propylene glycol or poly- second two that gargle, which leads to common solubilizer,
Alcohol and surfactant such as poloxamer and polysorbate.But solubilizer is frequently not suitable, they can assign order
The unhappy taste of people or feeling, such as specially chemicals taste, bitter taste or burning heat sensation.Solubilizer is also possible to be expensive, and
Largely processing is undesirable in processing factory.For example, ethyl alcohol is inflammable.It may also with the surfactant that high-content uses
Bitter taste or scent are assigned, and with the tendency for causing tissue inflammation and oral cavity to peel.In addition, surfactant may be to some
The bioavailability of active constituent has adverse effect.For example, surfactant may be mixed due to being formed in aqueous carrier
Micella is closed, these micellas influence bioavailability, to reduce cationic antimicrobial agent such as hexadecylpyridinium chloride (CPC)
With the bioavailability of chlorohexidene.
In addition, common functional component such as biological enzyme, peroxide, plant extracts etc. is not often in water in gargle
Stablize, the problems such as such as decomposing, change colour, is spoiled, it is this unstable the occurrence of, on the one hand can lead to gargle effect
Weaken or go bad during selling, is unfavorable for consumer's purchase.
To sum up, although existing gargle can meet the needs of consumer to a certain extent on the market, in some work(
In imitating the stability aspect of ingredient or being formulated during the use of solubilizer, there are certain deficiencies：
1, some functional components such as plant polyphenol, polyphosphate, peroxide, biological enzyme etc. cannot steadily be present in
In gargle.
2, for the liquid of homogeneous transparent is made, often increase solubilizer in gargle, solubilizer can cause to make us displeased
Happy mouthfeel or expensive or complicated for operation, production and use to gargle all cause deleterious effect.
Invention content
It gargles pearl and preparation method thereof it is an object of the invention to provide one kind, to overcome defect in the prior art,
The active constituent in pearl that makes to gargle is stabilized, to enhancing gargle pearl the effect of, keep suitable mouthfeel.
The second object of the present invention is to provide it is above-mentioned gargle pearl oral care liquid preparation field application.
The present invention realizes by following technical solution：
A kind of preparation method for pearl of gargling, includes the following steps：
1) by active constituent 1-99 parts be dispersed in 100 parts of emulsifiers, formed solution A；
2) colloid of 0.1-90 parts of crosslinkable polymerics is dissolved in 100 parts of water, forms solution B；
3) 0.1-99 parts of soluble divalent salts are dissolved in 100 parts of water, stirring forms solution C；
4) under conditions of high speed shear, solution A is added in solution B, and continues stirring to obtain emulsion；
5) emulsion is instilled by sieve pore in solution C, while cooling solution C, forms stable multilayer package and gargles
Mouth pearl.
The grain size of pearl obtained of gargling is 0.1-15mm.By spherical shape in emulsion or spherical droplets in cooling condition
In lower instillation solution C, with part colloid interfacial polymerization occurs for droplet surface bivalent cation in infall process, and formation is wrapped in
The shell of droplet surface, forms spherical or spherical particle, and the part colloid inside particle starts to be selfed in the cooling condition
The multilayer for joining and polymerizeing, thus form stabilization wraps up pearl of gargling can make work by above-mentioned lapping and the package of technical process
Property stable components be present in and gargle pearl, while can change the appearance for pearl of gargling by adding pigment.In addition, pearl of gargling can
With damaged by the effect of shearing force (fricting shearing act on) between such as tooth and pearl of gargling, thus in moment by active constituent
It releases.
Wherein, step 1) further includes：Essence is dispersed in 100 parts of emulsifiers for 1-99 parts, solution A is formed.
In particular, the active constituent include sodium phytate, polyphosphate, pearl powder, peroxide, biological enzyme, polypeptide,
Probiotics, western arsenic oronain, chlorohexidene, plant extracts, bio-vitric, strontium chloride, Paeonol, vitamins ingredient, 0- umbrellas flower
One or more of hydrocarbon -5- alcohol etc..Essence described in step 1 includes the volatile oil for being distilled or being squeezed out by plant and this
The component of a little volatile oil, such as Fructus Piperis peppermint oil, spearmint oil, Thymol, lemon oil, neroli oil, caryophyllus oil, fennel
One or more of oil, wintergreen, eucalyptus oil, cinnamon oil, tea oil mixture.Mentioned component cannot usually be stablized in water
In the presence of, however by being coated on and gargling pearl, enabling activity to stablize preservation, and then enhance the effect of gargling pearl, disappearing
In addition to many limitations to transparent gargle in the prior art.
Wherein, the emulsifier described in step 1) includes fatty acid glycerine esters, stearyl lactate/sodium, sapn, tween,
Propylene glycol esters, mannitol esters, the mixture of one or more of soy phospholipids.
Above-mentioned steps 2) in the colloid of involved crosslinkable polymeric include gellan gum, xanthans, carragheen, konjac glucomannan,
Agar, polyacrylamide, one kind in ammonio methacrylate copolymer analog and several mixtures.
Above-mentioned steps 3) in the involved salt containing bivalent cation include but not limited to Ca2+, Mg2+Equal salts.
Wherein, the rotating speed of the high speed shear of step 4) is 4000-10000rpm, and it is 10-30min to continue mixing time, is made
Solution A is uniform and stable to be dispersed in solution B, and emulsion is formed.
Wherein, the screen-aperture described in step 5) is 0.1mm-12mm, the temperature of cooling solution C be down to 30 DEG C hereinafter, from
And the grain size for controlling the pearl of gargling formed is 0.1-15mm.
Preparation method provided by the invention, active constituent, essence that can be not soluble in water or unstable by some etc. lead to
It crosses unique technique for packing and is prepared into the pellet for pearl of gargling, thus eliminate the gargle for producing clear homogeneous in the prior art
Many limitations, and have the following advantages that：
It is capable of providing the stability of active constituent, to enhance product efficacy；
Without other surfactants of high-content, to avoid the adverse effect of surfactant, such as to cationic season
The adverse effect of ammonium salt class antiseptic bioavailability；
Alcohol without high-content or other solvents to reduce cost, and avoid the negative effect from such solvent, packet
Safety and flavour problems are included, can be seasoned with broad range of flavor oil, including more hydrophobic and water solubility is those of relatively low,
Such as peppermint and spearmint；
The flavor oil than present feasible content higher amount can be used, to provide flavor sense or additional advantageous effect,
Without the alcohol for using high-content or other solvents；
After adding pigment, different color and lusters is presented in pearl of gargling, it is thus possible to provide unique or effective vision letter
Number, the gargle experience of different mouthfeels is provided；
Can include electrolyte, such as fluoride, nitrate, phosphate, pyrophosphate and to cationic quaternary ammonium salt it is anti-
Other salt that the bioavailability and/or gargle stability of microbial inoculum generally have adverse effect.
One kind is gargled pearl made from the above method.Pearl provided by the invention of gargling, have shield gum, mothproof, fresh breath,
Prevent dry effect, and keep the stability of active constituent, while active constituent sustained release can be made, it is ensured that has apparent
Long term；And keep suitable mouthfeel.
The present invention also provides a kind of application of the pearl in oral care product of gargling, the oral care product is gargled for one kind
Oral fluid, including：
Pearl provided by the invention of gargling, additive, the additive includes moisturizer, sweetener, pH adjusting agent, suspension
One or more of agent, coolant agent.
Pearl provided by the invention of gargling, can be applied to gargle, mouthwash, tooth gargle, mouth spraying agent, tooth solution and
In the liquid preparation of rinse fluid art.By in being coated on active constituent and gargling pearl, keeping the stability of active constituent, it being made to reach
At enough long terms, while active constituent sustained release can be made, it is ensured that liquid preparation has apparent long term；And
Can be quickly cruelly broken by the shear action of tooth when gargling, active constituent is discharged rapidly, the cleaning effect of product is enhanced.
Further, above-mentioned gargle made of pearl of gargling, according to mass percent meter, including following component：
1-70% gargles pearl；
5-60% moisturizer；
0.01-0.5% sweeteners；
0.01-0.8% pH adjusting agents；
0.01-2% suspending agents；
0.01-1% coolant agents；
Surplus is deionized water.
Wherein, the moisturizer is one or more of sorbierite, glycerine, antierythrite.
The suspending agent is one or more of xanthans, gellan gum, carragheen, carbomer.
The sweetener be one or both of xylitol, tri-chloro galactose type sugar, steviol glycoside, acesulfame potassium, saccharin sodium with
On.
The coolant agent is menthol, (N- ethyls-are to peppermint to menthyl -3- formamides (WS-3), acetic acid for N- ethyls -
Base -3- carboxylic acid amides) ethyl ester (WS-5), N-2,3- trimethyl isopropyl butyl amide (WS-23) it is one or two kinds of more than.
The present invention also specifically provides the preparation method of above-mentioned gargle：
1. deionized water is added by mass fraction in moisturizer, sweetener, pH adjusting agent, suspending agent, coolant agent and pigment
In, stirring 10-20min to solution is clarified；
2. the pearl that will gargle is added in above-mentioned solution, stirring at low speed is uniform；
3. can be obtained the rinse product containing pearl of gargling after filling.
The pearl of gargling of the present invention is applied to rinse product, compared with similar product in the prior art, product of the invention
With apparent advantage.Pearl of gargling during the production and transport of gargle is not easily damaged, is made by the shearing with tooth
With, the pearl that makes to gargle is broken, discharge active component, to reach prevent decayed tooth, fresh breath, tooth-whitening, mitigation sensitivity of tooth,
Safeguard the effect of gums healthy.Meanwhile the appearance of gargle and gargle appearance in the prior art are significantly different, showing has
The gargle of particle.In addition, after adding pigment, gargles pearl and different color and lusters can be presented in gargle, to form uniqueness
Visual effect.
Specific implementation mode
With reference to embodiment and test example, the present invention will be described in detail.
Embodiment 1
A kind of pearl of gargling containing biological enzyme, preparation method are as follows：
1.20 parts of lysozyme is dispersed in 100 parts of sad certain herbaceous plants with big flowers acid glycerol three esters, forms the solution A of lysozyme
2.5 parts of gellan gum is dissolved in 100 parts of water, forms gellan gum solution B；
3. 2 parts of calcium chloride is dissolved in 100 parts of water, stirring forms solution C；
4. under conditions of the high speed shear of 6000rpm speed, solution A is added in solution B, and continues to stir
15min makes solution A is uniform and stable to be dispersed in solution B, forms emulsion.
5. above-mentioned emulsion is instilled by the sieve pore of 10mm in solution C, while making the temperature of solution C by cooling device
Be reduced to 25 DEG C to get the pearl of gargling containing lysozyme.
The pearl of gargling that embodiment 1 provides has effects that protect gum, mothproof, fresh breath, prevents dry, and keep it is active at
The stability divided, while active constituent sustained release can be made, it is ensured that there is apparent long term；And keep suitable mouth
Sense.The preparation method of embodiment 1 is not necessarily to other surfactants, alcohol or the other solvents of high-content, to reduce cost, and
And the negative effect from such components is avoided, including safety and flavour problems, it can be seasoned with broad range of flavor oil.System
Lysozyme stable components exist in the pearl of gargling containing biological enzyme obtained, improve the effect of gargling pearl.
Embodiment 2
A kind of pearl of gargling containing Fructus Piperis peppermint oil, preparation method are as follows：
1.10 parts of Fructus Piperis peppermint oil is dispersed in 100 parts of three esters of triacetin, is formed containing the molten of Fructus Piperis peppermint oil
Liquid A
2.10 parts of carragheen is dissolved in 100 parts of water, forms carrageenan solutions B；
3. 2.5 parts of calcium chloride is dissolved in 100 parts of water, stirring forms solution C；
4. under conditions of the high speed shear of 7000rpm speed, solution A is added in solution B, and continues to stir
120min makes solution A is uniform and stable to be dispersed in solution B, forms emulsion.
5. above-mentioned emulsion is instilled by the sieve pore of 10mm in solution C, while making the temperature of solution C by cooling device
Be reduced to 20 DEG C to get the pearl of gargling containing Fructus Piperis peppermint oil.
The pearl of gargling that embodiment 2 provides has effects that protect gum, mothproof, fresh breath, prevents dry, and keep it is active at
The stability divided, while active constituent sustained release can be made, it is ensured that there is apparent long term；And keep suitable mouth
Sense.The preparation method of embodiment 2 is not necessarily to other surfactants, alcohol or the other solvents of high-content, to reduce cost, and
And the negative effect from such components is avoided, including safety and flavour problems, it can be seasoned with broad range of flavor oil.System
Fructus Piperis peppermint oil is stabilized in the pearl of gargling containing Fructus Piperis peppermint oil obtained, improves the effect of gargling pearl.
Embodiment 3
A kind of pearl of gargling of lysozyme and peppermint essence, preparation method are as follows：
1.30 parts of lyase and 15 parts of peppermint essence are dispersed in 100 parts of sad certain herbaceous plants with big flowers acid glycerol three esters,
Form solution A
2.15 parts of gellan gum is dissolved in 100 parts of water, forms carrageenan solutions B；
3. 5 parts of calcium chloride is dissolved in 100 parts of water, stirring forms solution C；
4. under conditions of the high speed shear of 6000rpm speed, solution A is added in solution B, and continues to stir
120min makes solution A is uniform and stable to be dispersed in solution B, forms emulsion.
5. above-mentioned emulsion is instilled by the sieve pore of 10mm in solution C, while making the temperature of solution C by cooling device
It is reduced to 20 DEG C of pearls of gargling to get lysozyme and Fructus Piperis peppermint oil.
The pearl of gargling that embodiment 3 provides has effects that protect gum, mothproof, fresh breath, prevents dry, and keep it is active at
The stability divided, while active constituent sustained release can be made, it is ensured that there is apparent long term；And keep suitable mouth
Sense.The preparation method of embodiment 3 is not necessarily to other surfactants, alcohol or the other solvents of high-content, to reduce cost, and
And the negative effect from such components is avoided, including safety and flavour problems, it can be seasoned with broad range of flavor oil.System
Lysozyme and peppermint essence are stabilized in the pearl of gargling obtained, improve the effect of gargling pearl.
Embodiment 4
A kind of gargle of pearl preparation of gargling using the embodiment of the present invention 3, preparation method are as follows：
1. by the glycerine of mass fraction 20%, 0.1% xylitol of mass fraction, 0.05% disodium hydrogen phosphate of mass fraction,
0.05% Natural menthol of mass fraction is added in deionized water, and stirring 10-20min to solution is clarified；
2. the pearl of gargling of the embodiment 3 of mass fraction 10% is added in above-mentioned solution, stirring at low speed is uniform；
3. can be obtained the rinse product containing pearl of gargling after filling.
The pearl of gargling of the present invention is applied to rinse product, and compared with similar product in the prior art, of the invention gargles
Liquid product has apparent advantage.By in being coated on active constituent and gargling pearl, keeping the stability of active constituent, it being made to reach
At enough long terms, while active constituent sustained release can be made, it is ensured that gargle has apparent long term；It is gargling
Pearl of gargling in the production process of oral fluid is not easily damaged, and by the shear action with tooth, the pearl that makes to gargle is broken, release activity at
Point, prevent decayed tooth, fresh breath, the effect for tooth-whitening, mitigating sensitivity of tooth, safeguarding gums healthy to reach.Meanwhile it gargling
The appearance of oral fluid and gargle appearance in the prior art are significantly different, show the gargle for having particle.In addition, in addition color
After element, gargles pearl and different color and lusters can be presented in gargle, to form unique visual effect.
Embodiment 5
For a kind of pearl of gargling using the embodiment of the present invention 3 in oral care product, the oral care product is gargle,
The preparation method of the gargle is as follows：
1. by the glycerine of mass fraction 12%, 0.1% xylitol of mass fraction, 0.05% disodium hydrogen phosphate of mass fraction,
0.05% Natural menthol of mass fraction is added in deionized water, and stirring 10-20min to solution is clarified；
2. the pearl of gargling of the embodiment 3 of mass fraction 30% is added in above-mentioned solution, stirring at low speed is uniform；
3. can be obtained the rinse product containing pearl of gargling after filling.
The pearl of gargling of the present invention is applied to rinse product, and compared with similar product in the prior art, of the invention gargles
Liquid product has apparent advantage.By in being coated on active constituent and gargling pearl, keeping the stability of active constituent, it being made to reach
At enough long terms, while active constituent sustained release can be made, it is ensured that gargle has apparent long term；It is gargling
Pearl of gargling in the production process of oral fluid is not easily damaged, and by the shear action with tooth, the pearl that makes to gargle is broken, release activity at
Point, prevent decayed tooth, fresh breath, the effect for tooth-whitening, mitigating sensitivity of tooth, safeguarding gums healthy to reach.Meanwhile it gargling
The appearance of oral fluid and gargle appearance in the prior art are significantly different, show the gargle for having particle.In addition, in addition color
After element, gargles pearl and different color and lusters can be presented in gargle, to form unique visual effect.
Comparative example 1
A kind of gargle, preparation method are, according to mass percent meter, including mixed solution made of following component：
0.5% lysozyme；
0.25% peppermint essence；
20% glycerine；
1.0% rilanit special；
0.15% xylitol；
0.05% disodium hydrogen phosphate；
0.05% Natural menthol；
And the deionized water of surplus.
Comparative example 2
A kind of gargle, preparation method are, according to mass percent meter, including mixed solution made of following component：
0.5% lysozyme；
0.25% peppermint essence；
20% glycerine；
1.0% rilanit special；
0.15% xylitol；
0.05% disodium hydrogen phosphate；
0.05% Natural menthol；
And the deionized water of surplus.
Test example 1
To investigate stability of the activity of lysozyme in gargle, by gargling obtained by above-described embodiment 4 and comparative example 1
Oral fluid is put into room temperature and 45 degree of baking oven simultaneously, the activity of enzyme in periodic detection product, and testing result is as shown in the table (single
Position：IU/g)：
From the above it is found that lysozyme is prepared into pearl of gargling, in being added to gargle, the steady of lysozyme is improved
It is qualitative, to be conducive to enhance product efficacy.
Test example 2
Gargle and common gargle prepared by embodiment 5 is defended using Ministry of Health of the People's Republic of China under the same conditions
Raw professional standard《Toothpaste efficiency evaluates third portion：Inhibit plaque and (or) mitigates gingivitis》Standard research techniques, comment
Valence improves situation to subject's plaque, and then protects gum effect to it and evaluate.Plaque index is changed using Quigley-Hein
Good Turesky plaque indexs evaluate supragingival plaque, are replaced using PI values, PI values are bigger, and it is more serious to represent bacterial plaque.Clinical examination
The results are shown in table below.
Clinical research shows using the gargle obtained by embodiment 5 compared with common gargle have and inhibit plaque
Formation effect.There is statistical significant difference (p ＜ 0.05) between 8 weeks groups.
According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and is changed.Therefore, the invention is not limited in specific implementation mode disclosed and described above, to the present invention/
Some modifications and changes should also be as falling into the scope of the claims of the present invention.In addition, although making in this specification
With some specific terms, these terms are merely for convenience of description, does not limit the present invention in any way.
Claims (10)
1. a kind of preparation method for pearl of gargling, which is characterized in that include the following steps：
1) by active constituent 1-99 parts be dispersed in 100 parts of emulsifiers, formed solution A；
2) colloid of 0.1-90 parts of crosslinkable polymerics is dissolved in 100 parts of water, forms solution B；
3) 0.1-99 parts of soluble divalent salts are dissolved in 100 parts of water, stirring forms solution C；
4) under conditions of high speed shear, solution A is added in solution B, and continues stirring to obtain emulsion；
5) emulsion is instilled by sieve pore in solution C, while cooling solution C, forms stable multilayer and wraps up pearl of gargling.
2. the preparation method of pearl according to claim 1 of gargling, which is characterized in that step 1) further includes：1-99 parts of essence is equal
It is even to be dispersed in 100 parts of emulsifiers, form solution A.
3. the preparation method of pearl according to claim 2 of gargling, which is characterized in that active constituent described in step 1) is phytic acid
Sodium, polyphosphate, pearl powder, peroxide, biological enzyme, polypeptide, probiotics, western arsenic oronain, chlorohexidene, plant extracts,
It is one or more in bio-vitric, strontium chloride, Paeonol, vitamins ingredient, 0- cymene -5- alcohol；The essence includes
Fructus Piperis peppermint oil, spearmint oil, Thymol, lemon oil, neroli oil, caryophyllus oil, fennel oil, wintergreen, eucalyptus oil, Chinese cassia tree
One or more of oil, tea oil mixture；The emulsifier includes fatty acid glycerine esters, stearyl lactate/sodium,
Sapn, tween, propylene glycol esters, mannitol esters, the mixture of one or more of soy phospholipids.
4. the preparation method of pearl according to claim 1 of gargling, which is characterized in that the rotating speed of the step 4) high speed shear is
4000~10000rmp；The aperture of the step 5) sieve pore is 0.1mm~15mm, and solution C is cooled to 0~30 DEG C.
5. the preparation method of pearl according to claim 1 of gargling, which is characterized in that involved crosslinkable polymeric in step 2)
Colloid includes gellan gum, xanthans, carragheen, konjac glucomannan, agar, polyacrylamide, ammonio methacrylate copolymer
One kind in class and several mixtures.
6. the preparation method of pearl according to claim 1 of gargling, which is characterized in that contain bivalent cation involved by step 3)
Salt include Ca2+, Mg2+Salt.
The pearl 7. one kind is gargled made from claim 1-6 any one of them preparation methods.
8. the oral care product of the pearl of gargling described in application claim 7, it is characterised in that：The oral care product is to gargle
Oral fluid, the gargle include：
The pearl of gargling of claim 7；
Additive, the additive include one kind or several in moisturizer, sweetener, pH adjusting agent, suspending agent, coolant agent
Kind.
9. application of the pearl in oral care product of gargling described in claim 7, which is characterized in that the gargle, according to
Mass percent meter, including following component：
10. application of the pearl in oral care product of gargling according to claim 9, which is characterized in that the moisturizing
Agent is one or more of sorbierite, glycerine, antierythrite；The suspending agent be xanthans, gellan gum, carragheen,
One or more of carbomer；The sweetener is xylitol, tri-chloro galactose type sugar, steviol glycoside, acesulfame potassium, saccharin sodium
One or more of；The coolant agent is menthol, N- ethyls-to menthyl -3- formamides, acetic acid (N- ethyls-right
Menthyl -3- carboxylic acid amides) ethyl ester, N-2,3- trimethyl isopropyl butyl amide it is one or two kinds of more than.
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