JP2980771B2 - Transparent liquid oral composition - Google Patents
Transparent liquid oral compositionInfo
- Publication number
- JP2980771B2 JP2980771B2 JP4092004A JP9200492A JP2980771B2 JP 2980771 B2 JP2980771 B2 JP 2980771B2 JP 4092004 A JP4092004 A JP 4092004A JP 9200492 A JP9200492 A JP 9200492A JP 2980771 B2 JP2980771 B2 JP 2980771B2
- Authority
- JP
- Japan
- Prior art keywords
- liquid oral
- viscosity
- transparent liquid
- oral composition
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Description
【０００１】[0001]
【産業上の利用分野】本発明は粘度を約２５℃で１５０
０〜１５０００センチポイズに調整し、長期に亘って透
明外観を安定して維持し、さらにブラッシング時に口中
にすみやかに分散する透明液状口腔用組成物に関する。BACKGROUND OF THE INVENTION The present invention has a viscosity of about 150 at about 25.degree.
The present invention relates to a transparent liquid oral composition which is adjusted to 0 to 15,000 centipoise, stably maintains a transparent appearance over a long period of time, and is promptly dispersed in the mouth during brushing.
【０００２】[0002]
【従来の技術・発明が解決しようとする課題】従来、口
腔衛生の手段として、練歯磨、水歯磨、洗口液等が用い
られている。練歯磨では、分散安定性・保型性の維持、
使用性の向上のために粘結剤を添加し、粘度を約５００
００センチポイズ以上に保つ必要があり、それゆえブラ
ッシング時の口中での薬剤分散性が悪くなるという問題
があった。2. Description of the Related Art Conventionally, toothpaste, water toothpaste, mouthwash, and the like have been used as means for oral hygiene. In toothpaste, maintaining dispersion stability and shape retention,
A binder is added to improve the usability, and the viscosity is about 500
It has to be kept at not less than 00 centipoise, so that there is a problem that the drug dispersibility in the mouth during brushing is deteriorated.
【０００３】また、水歯磨では、口中での薬剤分散性は
非常に良いが、粘度がかなり低いためブラッシング時
に、薬剤が口元からたれてくるという問題が生じてい
た。また、使用方法としてコップ等の容器に注ぎ、それ
を口に移すという手間も必要であった。[0003] In addition, in the case of water dentifrice, although the dispersibility of the drug in the mouth is very good, there is a problem that the drug drops from the mouth at the time of brushing due to its extremely low viscosity. In addition, as a method of use, it is necessary to pour a container such as a cup and transfer it to a mouth.
【０００４】一方、近年電動歯ブラシの普及に伴い、そ
の動きに適した剤型が望まれていた。練歯磨を電動歯ブ
ラシのブラシ部にのせ作動すると、ブラシの早い動きに
より練歯磨がブラシから落下する。また水歯磨だと、ブ
ラッシング時に薬剤が、口元からたれてくるため、使用
感が大変悪い。このため上記の問題点を解決する剤型と
して、水歯磨と練歯磨の中間の粘度を有し、口中分散性
が良い口腔用組成物の開発が望まれていた。On the other hand, with the spread of electric toothbrushes in recent years, a dosage form suitable for the movement has been desired. When the toothpaste is put on the brush portion of the electric toothbrush and operated, the toothpaste falls from the brush due to the rapid movement of the brush. In addition, when using toothpaste, the drug drops from the mouth when brushing, so the feeling of use is very poor. Therefore, as a dosage form that solves the above-mentioned problems, development of an oral composition having a viscosity intermediate between that of water toothpaste and toothpaste and having good dispersibility in the mouth has been desired.
【０００５】しかし、洗口液、水歯磨等の透明液体口腔
用組成物に粘度を上げるために通常用いられるカルボキ
シメチルセルロースナトリウム、キサンタンガム、ポリ
アクリル酸ナトリウム、ヒドロキシプロピルセルロー
ス、ヒドロキシエチルセルロース等の水溶性高分子を単
に配合するだけでは、長期保存によりおりの発生や白濁
が生じたり粘度の低下がおこるため、その商品価値を著
しく損なう。このため長期保存後においてもおりや白濁
がなく、透明外観を維持した安定な液状口腔用組成物が
望まれていた。[0005] However, water-soluble polymers such as sodium carboxymethylcellulose, xanthan gum, sodium polyacrylate, hydroxypropylcellulose, and hydroxyethylcellulose, which are commonly used to increase the viscosity of transparent liquid oral compositions such as mouthwashes and water dentifrices, are used. The simple blending of the molecules significantly reduces the commercial value of the product due to the generation of white turbidity and the decrease in viscosity due to long-term storage. Therefore, there has been a demand for a stable liquid oral composition which has no odor or cloudiness even after long-term storage and maintains a transparent appearance.
【０００６】本発明は、上記事情に鑑みなされたもの
で、水溶性高分子を含有した透明液状口腔用組成物を長
期間保存した場合でもその透明外観が良好に維持され、
使用感も良好な透明液状口腔用組成物を提供することを
目的とする。The present invention has been made in view of the above circumstances, and even when a transparent liquid oral composition containing a water-soluble polymer is stored for a long period of time, its transparent appearance is well maintained,
It is an object of the present invention to provide a transparent liquid oral composition having a good feeling in use.
【０００６】[0006]
【課題を解決するための手段】本発明は、グリセリン１
０〜１６重量％（以下％は重量％を示す。）、エタノー
ル８〜１６％、ポリオキシエチレン硬化ヒマシ油１．０
〜１．５％を含有した透明液状口腔用組成物において、
ヒドロキシエチルセルロースを０．５〜１．３％含有
し、該組成物の粘度を約２５℃で１５００〜１５０００
センチポイズに調製することにより、長期間保存した場
合でもおりや白濁の発生と粘度低下が防止され、その透
明外観が良好に維持され使用感も良好な本発明を完成す
るに至った。SUMMARY OF THE INVENTION The present invention provides a glycerin 1
0 to 16% by weight (hereinafter,% indicates% by weight), 8 to 16% of ethanol, 1.0% of polyoxyethylene hydrogenated castor oil
In a clear liquid oral composition containing ~ 1.5%,
The composition contains 0.5 to 1.3% of hydroxyethyl cellulose, and has a viscosity of about 1500 to 15000 at about 25 ° C.
By adjusting to centipoise, generation of odor and cloudiness and a decrease in viscosity are prevented even when stored for a long period of time, and the present invention has been completed in which the transparent appearance is well maintained and the usability is good.
【０００７】本発明で用いられるヒドロキシエチルセル
ロースは、セルロースから誘導される水溶性ノニオン性
の長鎖重合体である。性質は、各セルロース分子中のグ
ルコース単位当たりの酸化エチレンの平均付加モル数と
共に変わる。この平均付加モル数が１．３モル以上のも
のが水溶性となり、本発明の実施に対しては１．５モル
以上が適している。The hydroxyethyl cellulose used in the present invention is a water-soluble nonionic long-chain polymer derived from cellulose. Properties vary with the average number of moles of ethylene oxide added per glucose unit in each cellulose molecule. Those having an average addition mole number of 1.3 mol or more become water-soluble, and 1.5 mol or more is suitable for the practice of the present invention.
【０００８】本発明で用いられるヒドロキシエチルセル
ロースの透明液状口腔用組成物への配合量は、組成物全
体の０．５％〜１．３重量％の範囲であり、好ましく
は、０．６〜１．０重量％の範囲である。配合量が０．
５重量％より少ないと、粘度が十分でなく、また１．５
重量％を超えて配合すると、経時的に粘度変化が起こ
り、好ましくない。本発明に適した市販のヒドロキシエ
チルセルロースは、例えば、ＳＥ−４００，５００，５
５０，６００，８５０，９００（ダイセル化学工業株式
会社製）が挙げられる。The amount of hydroxyethylcellulose used in the present invention in the transparent liquid oral composition is in the range of 0.5% to 1.3% by weight, preferably 0.6% to 1.3% by weight of the whole composition. 0.0% by weight. The blending amount is 0.
If it is less than 5% by weight, the viscosity is not sufficient, and
If it is added in excess of weight%, the viscosity changes over time, which is not preferable. Commercially available hydroxyethylcellulose suitable for the present invention is, for example, SE-400,500,5.
50, 600, 850, 900 (manufactured by Daicel Chemical Industries, Ltd.).
【０００９】本発明で用いられるポリオキシエチレン硬
化ヒマシ油は、ヒマシ油の二重結合に水素を添加した硬
化ヒマシ油に酸化エチレンを付加重合したものである。The polyoxyethylene hydrogenated castor oil used in the present invention is obtained by adding ethylene oxide to hydrogenated castor oil obtained by adding hydrogen to the double bond of castor oil.
【００１０】本発明で用いられるポリオキシエチレン硬
化ヒマシ油の透明液体口腔用組成物への配合量は、組成
物全体に対して１．０〜１．５％の範囲であり、好まし
くは１．１〜１．３％の範囲である。配合量が１．０％
より少ないと香料を可溶化することが困難になり、また
１．５％をこえて配合すると、長期保存でおりや白濁が
生じたりする。本発明に適した市販のポリオキシエチレ
ン硬化ヒマシ油は、例えば、ＨＣＯ−４０，５０，６
０，８０，１００（ニッコーケミカル株式会社製）が挙
げられる。The amount of the polyoxyethylene hydrogenated castor oil used in the present invention in the transparent liquid oral composition is in the range of 1.0 to 1.5%, preferably 1. It is in the range of 1 to 1.3%. 1.0% compounding amount
If the amount is less, it becomes difficult to solubilize the fragrance, and if the amount is more than 1.5%, the fragrance may be stored for a long period of time or may become cloudy. Commercially available polyoxyethylene hydrogenated castor oil suitable for the present invention is, for example, HCO-40, 50, 6
0, 80, 100 (manufactured by Nikko Chemical Co., Ltd.).
【００１１】本発明の液状口腔用組成物のｐＨは、６〜
８の範囲に調整するのが好ましく、その範囲に保つ方法
は、特に制限されるものではないが、緩衝液を用いる方
法が好ましい。本発明に用いられる緩衝液としては、例
えば、リン酸２ナトリウムーリン酸１ナトリウム、クエ
ン酸３ナトリウムークエン酸、クエン酸２ナトリウムー
水酸化ナトリウム、塩酸ー炭酸ナトリウム等の緩衝液を
使用することができる。The pH of the liquid oral composition of the present invention is from 6 to
It is preferable to adjust to a range of 8, and the method for keeping the range is not particularly limited, but a method using a buffer is preferable. As the buffer used in the present invention, for example, buffers such as disodium phosphate-monosodium phosphate, trisodium citrate-citric acid, disodium citrate-sodium hydroxide, and hydrochloric acid-sodium carbonate are used. Can be.
【００１２】本発明で用いられる香料の透明液体口腔用
組成物への配合料は、組成物全量に対して、０．３〜
１．０％の範囲である。配合料が０．３％より少ない
と、ブラッシング時の清涼感が弱く、また、１．０％を
こえて配合すると、口腔粘膜への刺激が強くなる。The compounding amount of the fragrance used in the present invention in the composition for a transparent liquid oral cavity is from 0.3 to 0.3% based on the total amount of the composition.
The range is 1.0%. If the compounding amount is less than 0.3%, the refreshing feeling at the time of brushing is weak, and if the compounding amount is more than 1.0%, irritation to the oral mucosa is increased.
【００１３】本発明の透明液体口腔用組成物にはこれら
の成分の他にも、通常口腔用組成物に配合される基剤や
種々の添加剤を配合してもよい。例えば、塩化セチルピ
リジニウム、塩化デカリニウム、トリクロサン、クロル
ヘキシジン類等の殺菌剤、抗炎症剤等の有効成分、界面
活性剤、ＰＨ調整剤、粘ちょう剤、精油、甘味剤および
防腐剤等が適宜配合される。The transparent liquid oral composition of the present invention may contain, in addition to these components, a base and various additives which are usually added to the oral composition. For example, bactericides such as cetylpyridinium chloride, decalinium chloride, triclosan, and chlorhexidine, active ingredients such as anti-inflammatory agents, surfactants, PH regulators, thickeners, essential oils, sweeteners, preservatives and the like are appropriately compounded. You.
【００１４】[0014]
【実施例】以下、実施例および比較例を示し、本発明を
さらに具体的に説明するがこれらに限定されるものでは
ない。 実施例１〜９および比較例１０〜２１ １．粘度の測定方法 各成分を調整し、該組成物を調整初日および４０℃にて
３ヶ月保存した後、２５℃においてブルックフィールド
粘度計（ロータＮｏ．３）により粘度を測定した。 ２．外観の測定方法 各成分を調整し、該組成物を４０℃にて３ヶ月保存した
後、目視にて外観、即ち白濁もしくはおりの発生ついて
肉眼判定した。その結果を表１、表２に示す。なお、効
果の判定基準は以下の通りである。 外観 ○：白濁もしくはおりの発生がなく、透明である。 △：白濁もしくはおりの発生がややある。 ×：白濁もしくはおりの発生がある。 粘度 ○：粘度減少率が初日に対し２０％未満 △：粘度減少率が初日に対し、２０％以上から４０％未
満 ×：粘度減少率が初日に対し、４０％以上 総合評価 ○：外観、粘度ともに○の場合。 ×：外観、粘度ともに○でない場合。The present invention will be described in more detail with reference to the following Examples and Comparative Examples, but it should not be construed that the invention is limited thereto. Examples 1 to 9 and Comparative Examples 10 to 21 Viscosity measuring method Each component was adjusted, and the composition was stored on the first day of the adjustment and at 40 ° C. for 3 months, and then the viscosity was measured at 25 ° C. with a Brookfield viscometer (Rotor No. 3). 2. Method for Measuring Appearance Each component was adjusted, and the composition was stored at 40 ° C. for 3 months, and then visually evaluated for appearance, that is, occurrence of cloudiness or cage. The results are shown in Tables 1 and 2. The criteria for determining the effect are as follows. Appearance ：: Transparent without generation of cloudiness or scent. Δ: Some clouding or odor was generated. ×: There is cloudiness or scent. Viscosity ：: Viscosity reduction rate is less than 20% on the first day △: Viscosity reduction rate is 20% or more and less than 40% on the first day ×: Viscosity reduction rate is 40% or more on the first day Overall evaluation ：: Appearance, viscosity When both are ○. ×: Both appearance and viscosity are not ○.
【００１５】[0015]
【表１】 [Table 1]
【００１６】[0016]
【表２】 [Table 2]
【００１７】表１、表２の結果により実施例１〜９の透
明液状口腔用組成物は、いずれも白濁もしくはおりが発
生することなく透明であり、粘度も経時的に安定であっ
た。According to the results shown in Tables 1 and 2, each of the transparent liquid oral compositions of Examples 1 to 9 was transparent without generation of cloudiness or odor, and viscosity was stable with time.
【発明の効果】本発明によれば、長期に亘って透明外観
を安定に維持し、さらにブラッシング時に口中にすみや
かに分散する透明液状口腔用組成物を得ることができ
る。According to the present invention, it is possible to obtain a transparent liquid oral composition which stably maintains a transparent appearance for a long period of time and which is promptly dispersed in the mouth during brushing.
フロントページの続き (58)調査した分野(Int.Cl.6，ＤＢ名) A61K 7/16 Continuation of front page (58) Field surveyed (Int.Cl. 6 , DB name) A61K 7/16
Claims (1)
ル８〜１６重量％、ポリオキシエチレン硬化ヒマシ油
１．０〜１．５重量％を含有した透明液状口腔用組成物
において、ヒドロキシエチルセルロースを０．５〜１．
３重量％含有し、該組成物の粘度を約２５℃で１５００
〜１５０００センチポイズに調整したことを特徴とする
透明液状口腔用組成物。1. A transparent liquid oral composition containing 10 to 16% by weight of glycerin, 8 to 16% by weight of ethanol, and 1.0 to 1.5% by weight of polyoxyethylene hydrogenated castor oil. 5-1.
3% by weight and the viscosity of the composition is 1500 at about 25 ° C.
A composition for a transparent liquid oral cavity, which is adjusted to 15000 centipoise.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4092004A JP2980771B2 (en) | 1992-03-17 | 1992-03-17 | Transparent liquid oral composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4092004A JP2980771B2 (en) | 1992-03-17 | 1992-03-17 | Transparent liquid oral composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05262628A JPH05262628A (en) | 1993-10-12 |
| JP2980771B2 true JP2980771B2 (en) | 1999-11-22 |
Family
ID=14042297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4092004A Expired - Lifetime JP2980771B2 (en) | 1992-03-17 | 1992-03-17 | Transparent liquid oral composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2980771B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3531240B2 (en) * | 1994-10-13 | 2004-05-24 | ライオン株式会社 | Mouthwash composition |
| WO2013180019A1 (en) * | 2012-05-28 | 2013-12-05 | ライオン株式会社 | Liquid oral composition |
-
1992
- 1992-03-17 JP JP4092004A patent/JP2980771B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05262628A (en) | 1993-10-12 |
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