CN113749983A - Volume-production anhydrous toothpaste - Google Patents
Volume-production anhydrous toothpaste Download PDFInfo
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- CN113749983A CN113749983A CN202111064023.5A CN202111064023A CN113749983A CN 113749983 A CN113749983 A CN 113749983A CN 202111064023 A CN202111064023 A CN 202111064023A CN 113749983 A CN113749983 A CN 113749983A
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- toothpaste
- carbomer
- pvp
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a mass-production anhydrous toothpaste, which comprises the following paste components in percentage by mass: 4-9% of functional components, 10-20% of abrasive, and adhesive: 0.2-0.7% of PVP, 0.3-0.7% of carbomer, 63-87% of humectant, 1-2.5% of foaming agent, 0.1-4.0% of sweetening agent, 0.3-1.3% of essence and 0-1.0% of titanium dioxide; the process requirements of mixing the components in the stirring scraper blade process are as follows: stirring speed: 800-: 20-30rpm, process time: 30-45 min. The adhesive PVP and carbomer are compounded in a certain proportion in the formula, so that the viscosity of the paste is reduced, the striping property is good, the fluidity is good, the stability is good, the problem of filling and volume production is solved, and the stability and no oil is produced in the quality guarantee period of the toothpaste is achieved.
Description
Technical Field
The invention relates to the field of anhydrous toothpaste production, in particular to a mass production anhydrous toothpaste.
Background
With the improvement of living standard of people and the transformation of consumption concept, the importance of health and safety in the mind of consumers is ranked first. Fluoride is generally added into the traditional mothproof toothpaste; the anti-allergic toothpaste is generally added with potassium salt and strontium salt; phytate and phosphate are generally added into the whitening toothpaste; chinese herbal medicines are generally added in toothpaste for relieving gingival bleeding and periodontitis. The anhydrous toothpaste is different from the traditional toothpaste, the toothpaste raw materials without free water are selected, no water is added in the formula, the functional ingredients are released when meeting saliva of the oral cavity when a consumer uses the anhydrous toothpaste, the efficacy required by the consumer can be achieved without adding the raw materials and any preservative, the key is good safety, and children and pregnant women can use the anhydrous toothpaste safely.
In the anhydrous toothpaste systems currently on the market, carbomer is generally used as a thickening agent, because the thickening agent used in ordinary toothpaste is not dissolved in an anhydrous state, and carbomer molecules are used as carboxyl donors and can be combined with one or more than two hydroxyl groups to form hydrogen bonds to thicken (polyhydric alcohol). The finished toothpaste is required to keep good stability and no dehydration separation phenomenon in the storage process of the retention period. The requirement is that the components are fully blended by homogenizing and stirring for a certain time period under the stirring and grinding process in paste production. However, carbomer is fully called as acrylic resin, the paste is too viscous when the stirring time is too long, the striping property is poor, the fluidity is poor, the resistance is high during filling, and the filling speed of a production line can only reach 35-45 counts/min. At present, anhydrous toothpaste is a continuously growing market segment, but the toothpaste is a low-profit product and needs to be produced in batches to reach a certain number to benefit space. Therefore, when toothpaste enterprises produce anhydrous toothpaste, the stirring and grinding time is shortened to improve the fluidity of the paste so as to solve the filling problem, the filling speed is 80-100 counts/min, and the mass production is realized. However, the stability of the paste in later storage is sacrificed, and the paste begins to produce oil after being stored at room temperature for 6-8 months.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the mass-production anhydrous toothpaste for solving the problems, the adhesive PVP and carbomer are compounded according to a certain proportion in the formula, so that a certain time duration in the stirring and grinding process is ensured, the viscosity of the toothpaste is reduced, the striping property is good, the fluidity is good, the stability is good, the problem of filling and mass production is solved, and the purpose that stable oil cannot be produced in the quality guarantee period of the toothpaste is achieved.
In order to achieve the purpose, the invention provides the following technical scheme:
the mass production anhydrous toothpaste comprises the following paste components in percentage by mass:
4-9% of bioactive glass, 10-20% of abrasive, and adhesive: 0.2-0.7% of PVP, 0.3-0.7% of carbomer, 63-87% of humectant, 1-2.5% of foaming agent, 0.1-4.0% of sweetening agent, 0.3-1.3% of essence and 0-1.0% of titanium dioxide;
the process requirements of mixing the components in the stirring scraper blade process are as follows:
stirring speed: 800-: 20-30rpm, process time: 30-45 min.
The invention further improves the technical scheme that PVP refers to FlexithixTM。
The invention further improves the technical proposal that the calcium sodium phosphosilicate is 4 to 9 percent, the hydrated silica is 10 to 20 percent, the PVP is 0.2 to 0.7 percent, the carbomer is 0.3 to 0.7 percent, the polyethylene glycol-815 to 22 percent, the glycerol is 48 to 65 percent, the foaming agent is 1 to 2.5 percent, the sweetening agent is 0.1 to 4.0 percent, the essence is 0.3 to 1.3 percent, and the titanium pigment is 0 to 1 percent;
the invention further improves the technical scheme that the foaming agent is one or more of sodium lauroyl glutamate, sodium cocoyl methyl taurate and sodium lauryl sulfate.
The technical scheme of the further improvement of the invention is that the sweetening agent is one or more of xylitol, trichlorogalactose, saccharin sodium and AK sugar.
The invention has the beneficial effects that:
firstly, the binding agent in the formula is compounded by PVP and carbomer according to a certain proportion, so that the contradiction that the binding agent in the anhydrous toothpaste is singly added with carbomer, if the stirring time is long and the stability is good, but the volume production cannot be realized, if the stirring time is short, the volume production filling is realized, but the paste stability is poor, and the oil is produced in the quality guarantee period, is not well blended is solved. Carbomer is a high molecular polymer of acrylic acid bonded allyl sucrose or pentaerythritol allyl ether, and contains 56.0-68.0% of carboxylic acid group (-COOH) calculated on a dry product. Carbomer molecules act as carboxyl donors and can combine with one or more hydroxyl groups to form hydrogen bonds for thickening, and the hydrogen bonds and intermolecular forces form threads. The hydrated silica which is greatly existed in the toothpaste formula has the advantages that silicon hydroxyl can form a hydrogen bond with carbomer, and silicon ions can be complexed with carboxyl, so that the acting force is high. The longer the stirring time, the more severe the stringiness, and the poorer the paste rheology when carbomer alone was added. After the PVP is added, the PVP has stronger adsorbability and is adsorbed on the surface of silicon dioxide, and the upper layer of the surface is non-polar polyethylene, so that the wire drawing phenomenon is reduced, and the flexibility is good; in addition, PVP can also reduce intermolecular force of the powder to play a role in dispersing and reducing viscosity. Therefore, the paste body added with PVP can be stirred for a longer time, so that all components are fully mixed, the stability of the paste body is improved, meanwhile, the paste body still has better rheological property, the resistance is small during actual filling, the filling speed can reach 80-100 counts/min, the influence of the environment and the temperature of the paste body is not great, the paste body can be produced in batch like the water-based toothpaste, the production cost is greatly reduced, and the anhydrous toothpaste is more civilized; the paste is fully stirred and fused, the stability in later storage is good, the test of accelerated aging stability in a 45 ℃ oven shows that the paste is stable for 3 months, the paste is normal, does not become thin and does not produce oil, and the paste can be stored for more than 3 years at room temperature.
And secondly, the bioactive glass, namely the calcium sodium phosphosilicate, is widely applied to oral care products. It has effects of strengthening and consolidating teeth, treating dentin hypersensitiveness, gingival atrophy, gingival hemorrhage, canker sore, preventing dental caries, and eliminating smoke stain and halitosis. The oral materials with such comprehensive and extensive effects on the market are seen slightly, and are a revolution in the oral health care technology.
Detailed Description
Comparative example 1
Formulation of
| Serial number | Name of raw materials | In proportion% |
| 1 | Calcium sodium phosphosilicate | 4.0-9.0 |
| 2 | PVP | / |
| 3 | Polyethylene glycol-8 | 15.0-22.0 |
| 4 | Glycerol | 48.0-65.0 |
| 5 | Hydrated silica | 10.0-20.0 |
| 6 | Carbomer | 0.3-0.7 |
| 7 | Foaming agent | 1.0-2.0 |
| 8 | Sweetening agent | 0.1-0.25 |
| 9 | Essence | 0.5-1.3 |
| 10 | Titanium white powder | 0-1.0 |
The process requirements of mixing the components in the stirring scraper blade process are as follows:
stirring speed: 800-: 20-30rpm, process time: 30-45 min.
Stability test result at 45 ℃ of formula
The quality guarantee period of the toothpaste is 2-3 years generally, and the paste body is required to keep stable in the later half of the quality guarantee period. Comparative example 1 oven accelerated aging stability test result at 45 ℃ oil production begins in 2 months, the later period is more and more serious, and oil production begins when the corresponding room temperature storage is about 2 years generally.
However, the paste is too viscous, the viscosity is 200000-.
Comparative example 2
The formula is the same as that of comparative example 1, the process requirements of mixing the components in the processes of scraping, stirring and grinding are only 15-25min, and the rest is the same. The paste viscosity is 50000-150000 mpa.s, the viscosity is reduced, the striping property is good, the fluidity is good, the resistance is small during actual filling, the filling can be carried out at 80-100 counts/min, the influence of the environment and the paste temperature is large, and the mass production can be realized.
Stability test result at 45 ℃ of formula
Comparative example 2 test result of accelerated aging stability of oven at 45 ℃ shows that oil is produced after 1 week, the later period is more and more serious, the oil is produced after the corresponding room temperature storage for 6-8 months generally, and the requirement of storage stability of the paste cannot be met.
Example 1
Test 1 formulation
| Serial number | Name of raw materials | In proportion% |
| 1 | Calcium sodium phosphosilicate | 4.0 |
| 2 | FlexithixTM | 0.2 |
| 3 | Polyethylene glycol-8 | 20.9 |
| 4 | Glycerol | 57.0 |
| 5 | Hydrated silica | 14.0 |
| 6 | Carbomer | 0.6 |
| 7 | Sodium lauroyl glutamate | 2.0 |
| 8 | Xylitol, its preparation method and use | 0.1 |
| 9 | Sucralose | 0.20 |
| 10 | Essence | 1.0 |
The process requirements of mixing the components in the stirring scraper blade process are as follows:
stirring speed: 800rpm, blade speed: 20rpm, process time: and (4) 45 min.
Test 1 formula 45 ℃ stability test results
The quality guarantee period of the toothpaste is 2-3 years generally, and the paste body is required to keep stable in the later half of the quality guarantee period. Example 1 oven accelerated aging stability test results at 45 ℃ oil did not appear for 3 months, corresponding to 3 years storage at room temperature.
Example 2
Test 2 formulation
| Serial number | Name of raw materials | In proportion% |
| 1 | Calcium sodium phosphosilicate | 8.5 |
| 2 | FlexithixTM | 0.5 |
| 3 | Polyethylene glycol-8 | 20.0 |
| 4 | Glycerol | 49.15 |
| 5 | Hydrated silica | 18.0 |
| 6 | Carbomer | 0.3 |
| 7 | Sodium cocoyl methyl taurate | 1.5 |
| 8 | Trichlorogalactose | 0.25 |
| 9 | Essence | 1.3 |
| 10 | Titanium white powder | 0.5 |
The process requirements of mixing the components in the stirring scraper blade process are as follows:
stirring speed: 1000rpm, blade speed: 30rpm, process time: and (3) 30 min.
Test 2 formula 45 ℃ stability test results
Example 2 oven accelerated aging stability test results at 45 ℃ results in no oil for 3 months, corresponding to 3 years of storage at room temperature.
Example 3
Test 3 formulation
| Serial number | Name of raw materials | In proportion% |
| 1 | Calcium sodium phosphosilicate | 6.0 |
| 2 | FlexithixTM | 0.7 |
| 3 | Polyethylene glycol-8 | 15.0 |
| 4 | Glycerol | 58.8 |
| 5 | Hydrated silica | 12.0 |
| 6 | Carbomer | 0.3 |
| 7 | Sodium lauryl sulfate | 1.8 |
| 8 | Xylitol, its preparation method and use | 4 |
| 9 | Essence | 0.6 |
| 10 | Titanium white powder | 0.8 |
The process requirements of mixing the components in the stirring scraper blade process are as follows:
stirring speed: 900rpm, blade speed: 25rpm, process time: and (4) 40 min.
Experiment 3 formula 45 ℃ stability test results
Example 3 oven accelerated aging stability test results at 45 ℃ results in no oil for 3 months, corresponding to 3 years of storage at room temperature.
Meanwhile, the paste produced in the examples 1, 2 and 3 has the viscosity of 30000-150000 mpa.s, the viscosity is reduced, the striping property is good, the fluidity is good, the resistance is small during actual filling, the filling can be carried out at 80-100 counts/min, the influence of the environment and the paste temperature is large, and the mass production can be realized.
The above-mentioned embodiments are only for convenience of illustration and not intended to limit the invention in any way, and those skilled in the art will be able to make equivalents of the features of the invention without departing from the technical scope of the invention.
Claims (5)
1. Volume production anhydrous toothpaste, its characterized in that: the paste comprises the following components in percentage by mass:
4-9% of bioactive glass, 10-20% of abrasive, and adhesive: 0.2-0.7% of PVP, 0.3-0.7% of carbomer, 63-87% of humectant, 1-2.5% of foaming agent, 0.1-4.0% of sweetening agent, 0.3-1.3% of essence and 0-1.0% of titanium dioxide;
the process requirements of mixing the components in the stirring scraper blade process are as follows:
stirring speed: 800-: 20-30rpm, process time: 30-45 min.
2. The mass produced anhydrous toothpaste according to claim 1, wherein: PVP means FlexithixTM。
3. The mass produced anhydrous toothpaste according to claim 1, wherein: 4-9% of calcium sodium phosphosilicate, 10-20% of hydrated silica, 0.2-0.7% of PVP, 0.3-0.7% of carbomer, 0-815-22% of polyethylene glycol, 48-65% of glycerol, 1-2.5% of foaming agent, 0.1-4% of sweetening agent, 0.3-1.3% of essence and 0-1.0% of titanium dioxide.
4. The mass produced anhydrous toothpaste according to claim 1, wherein: the foaming agent is one or more of sodium lauroyl glutamate, sodium cocoyl methyl taurate and sodium lauryl sulfate.
5. The mass produced anhydrous toothpaste according to claim 1, wherein: the sweetener is one or more of xylitol, trichlorogalactose, saccharin sodium and AK sugar.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111064023.5A CN113749983A (en) | 2021-09-10 | 2021-09-10 | Volume-production anhydrous toothpaste |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111064023.5A CN113749983A (en) | 2021-09-10 | 2021-09-10 | Volume-production anhydrous toothpaste |
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| CN113749983A true CN113749983A (en) | 2021-12-07 |
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| CN202111064023.5A Pending CN113749983A (en) | 2021-09-10 | 2021-09-10 | Volume-production anhydrous toothpaste |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115670949A (en) * | 2021-12-27 | 2023-02-03 | 上海优萃生物科技有限公司 | Anhydrous toothpaste for whitening and stain removing of teeth and preparation method thereof |
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| CN106890103A (en) * | 2017-03-06 | 2017-06-27 | 广州薇美姿实业有限公司 | A kind of toothpaste suitable for pump type packaging material and preparation method thereof |
| CN109771319A (en) * | 2017-11-10 | 2019-05-21 | 重庆登康口腔护理用品股份有限公司 | A kind of bioactivity glass (ceramics) material and casein phosphopeptide composition and its application in oral care implement |
| CN110801404A (en) * | 2019-11-19 | 2020-02-18 | 庐山百草堂生物制药有限公司 | Dihydromyricetin-containing tooth whitening and repairing toothpaste and preparation method thereof |
| WO2021067683A1 (en) * | 2019-10-02 | 2021-04-08 | Isp Investments Llc | Carbomer based tooth paste composition comprising crosslinked polyvinylpyrrolidone for building viscosity |
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2021
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Patent Citations (6)
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| CN1660036A (en) * | 2004-12-22 | 2005-08-31 | 美晨集团股份有限公司 | Compound formula of toothpaste |
| WO2016011978A1 (en) * | 2014-07-24 | 2016-01-28 | 北京大清生物技术有限公司 | Composition with multiple oral treatment and healthcare functions and preparation method therefor |
| CN106890103A (en) * | 2017-03-06 | 2017-06-27 | 广州薇美姿实业有限公司 | A kind of toothpaste suitable for pump type packaging material and preparation method thereof |
| CN109771319A (en) * | 2017-11-10 | 2019-05-21 | 重庆登康口腔护理用品股份有限公司 | A kind of bioactivity glass (ceramics) material and casein phosphopeptide composition and its application in oral care implement |
| WO2021067683A1 (en) * | 2019-10-02 | 2021-04-08 | Isp Investments Llc | Carbomer based tooth paste composition comprising crosslinked polyvinylpyrrolidone for building viscosity |
| CN110801404A (en) * | 2019-11-19 | 2020-02-18 | 庐山百草堂生物制药有限公司 | Dihydromyricetin-containing tooth whitening and repairing toothpaste and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115670949A (en) * | 2021-12-27 | 2023-02-03 | 上海优萃生物科技有限公司 | Anhydrous toothpaste for whitening and stain removing of teeth and preparation method thereof |
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