CN113576995A - Dendrobium anti-inflammation toothpaste and preparation method thereof - Google Patents
Dendrobium anti-inflammation toothpaste and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a dendrobium anti-inflammation toothpaste and a preparation method thereof, wherein the dendrobium anti-inflammation toothpaste comprises dendrobium officinale flavone, dendrobium officinale alkali, dendrobium officinale phenylpropanoid, cellulose gum, tetrasodium pyrophosphate, sorbitol, hydrated silica, water, nano tin oxide, nano mica, nano titanium dioxide, glycerol, polyethylene glycol-8, acesulfame-K, nano zinc citrate, sodium lauryl sulfate, sodium lauroyl sarcosinate, trichlorogalactose, sodium benzoate, corn starch, microcrystalline cellulose, essence, wrinkled giant hyssop, mannitol and biological phenol acetate. The active ingredients of the invention are in a nano shape, and the dendrobium officinale extract is adopted, so the effective anti-inflammatory, hemostatic, detumescence and antibacterial ingredients can still be attached to teeth or gum or oral mask for a long time after tooth brushing and mouth rinsing, and the effects of long-time bacteriostasis, anti-inflammation, oral cavity cleaning, breath freshening, gum protection and tooth strengthening, gum and periodontal tissue health maintenance and oral environment improvement are achieved.
Description
Technical Field
The invention relates to the technical field of oral care, in particular to dendrobium anti-inflammation toothpaste and a preparation method thereof.
Background
Toothpaste is a product for oral cleaning, which is generally applied to a toothbrush to clean the surfaces of the left and right teeth by mechanical friction of the toothbrush.
With the improvement of living standard, the requirement of people on oral care is higher and higher. On one hand, the tooth appearance needs to be protected, and the gum monitoring needs to be protected to prevent halitosis and the like. On the other hand, the toothpaste product also has the requirement of diminishing inflammation and protecting teeth.
After people usually brush teeth and rinse mouth, because the last rinse of the rinse water can wash away the effective components of diminishing inflammation and removing fire of the toothpaste in the prior art, even if the effective components of diminishing inflammation and inhibiting bacteria exist in the existing toothpaste, the toothpaste can not be kept in the oral cavity for a long time, and the effects of diminishing inflammation, removing fire and cleaning the oral cavity for a long time can not be achieved. Therefore, after people rinse the mouth, the toothpaste can also play a role in inhibiting bacteria, removing fire, diminishing inflammation, removing peculiar smell and effectively preventing gingival bleeding for a long time, and the technical problem of hard attack is urgently needed after long-time inflammation and bacteria resistance.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the dendrobium anti-inflammatory toothpaste, which has effective anti-inflammatory and antibacterial components, can still be attached to teeth or gums or oral masks for a long time after tooth brushing and mouth rinsing, and has the effects of inhibiting bacteria, diminishing inflammation, cleaning oral cavities, refreshing breath, protecting gums and teeth really, maintaining health of gum and periodontal tissues and improving the oral environment.
In order to solve the problems in the prior art, the adopted specific technical scheme is as follows:
the dendrobium anti-inflammatory toothpaste comprises the following components in parts by weight:
preferably, the dendrobium officinale extract comprises dendrobium officinale flavone, dendrobium officinale alkali and dendrobium officinale phenylpropanoid.
Preferably, the dendrobium anti-inflammatory toothpaste also comprises the following components in parts by weight:
preferably, the dendrobium anti-inflammatory toothpaste also comprises the following components in parts by weight:
preferably, the dendrobium anti-inflammatory toothpaste also comprises the following components in parts by weight:
preferably, the dendrobium anti-inflammatory toothpaste also comprises the following components in parts by weight:
2-4 parts of mannitol
6-9 parts of biological phenol acetate.
The invention also provides a preparation method of the dendrobium anti-inflammatory toothpaste, which comprises the following steps:
step one, preparing a nano-scale raw material;
placing the dendrobium officinale extract, cellulose gum, tetrasodium phosphate, sorbitol, hydrated silica, water, tin oxide, mica and titanium dioxide into a ball mill, setting the rotating speed of the ball mill to be 500-800 rpm, and polishing for 1-2 hours to form an aqueous phase solution;
step two, preparing the dendrobium anti-inflammatory toothpaste;
mixing the water phase solution product obtained in the step one with glycerol, polyethylene glycol-8, acesulfame-K, nano zinc citrate, sodium lauryl sulfate, sodium lauroyl sarcosinate, trichlorogalactose, sodium benzoate, corn starch, microcrystalline cellulose, essence, Chondrus crispus, mannitol and biological phenol acetate, adding into a cell ultrasonic crusher, and performing ultrasonic dispersion; the power of ultrasonic dispersion is 500-800W, and the ultrasonic dispersion is carried out for 30 minutes; and filling the product after ultrasonic dispersion into bottles to obtain the finished dendrobium anti-inflammatory toothpaste.
Preferably, the tin oxide, the mica and the titanium dioxide in the first step are ground into a nanometer shape.
Preferably, the weight parts of each component in the first step and the second step are as follows: 30-50 parts of dendrobium officinale extract, 10-20 parts of cellulose gum, 15-25 parts of tetrasodium pyrophosphate, 8-15 parts of sorbitol, 5-10 parts of hydrated silica, 40-60 parts of water, 50-80 parts of tin oxide, 30-60 parts of mica, 20-30 parts of titanium dioxide, 20-30 parts of glycerol, 15-35 parts of polyethylene glycol-8, 10-20 parts of butyl carbamate, 15-20 parts of nano zinc citrate, 8-13 parts of sodium lauryl sulfate, 5-15 parts of sodium lauroyl sarcosinate, 12-15 parts of trichlorogalactose, 8-10 parts of sodium benzoate, 3-5 parts of corn starch, 2-5 parts of microcrystalline cellulose, 7-12 parts of essence, 8-10 parts of crinkle carrageenan, 2-4 parts of mannitol and 6-9 parts of biological phenol acetate.
By adopting the scheme, compared with the prior art, the dendrobium anti-inflammation toothpaste and the preparation method thereof have the technical effects that:
1. the oral liquid contains the dendrobium officinale extract, and the dendrobium officinale extract has extremely strong viscosity, so that effective anti-inflammatory and antibacterial components in the oral liquid can be adsorbed on teeth, gums and oral intima together, and cannot be washed away by mouth wash even after tooth brushing, and therefore the oral liquid can play a role in inhibiting bacteria, diminishing inflammation, eliminating peculiar smell and promoting healing of fine oral wounds for a long time.
2. The raw materials of the invention are made of nano-grade powder, which can also effectively help the effective antibacterial and anti-inflammatory components to be freely adsorbed in the oral cavity.
3. The dendrobium officinale adopted by the invention has the effects of tonifying qi and promoting the production of body fluid, nourishing yin and removing heat, reducing swelling and promoting granulation, and dredging collaterals and relieving pain, and can obviously prevent and improve symptoms of oral ulcer, gum swelling and pain, bleeding and halitosis.
4. The invention adopts nano titanium dioxide as an efficient and nontoxic photocatalyst, and the nano titanium dioxide can play a role in whitening teeth when being used in toothpaste.
5. The zinc citrate adopted by the invention can effectively improve the flora in the oral cavity, thereby playing the roles of cleaning the oral cavity and refreshing the breath.
6. The dendrobium officinale extract disclosed by the invention is prepared from dendrobium officinale flavone, dendrobium officinale alkali and dendrobium officinale phenylpropanoid, wherein the molecular formula of the dendrobium officinale alkali is C16H25NO2, and the dendrobium officinale flavone and the dendrobium officinale phenylpropanoid are matched, so that the toothpaste disclosed by the invention has the effects of inhibiting bacteria, relieving heat, relieving pain, resisting inflammation, stopping bleeding and diminishing swelling.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to specific examples below. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
Embodiment 1, the dendrobium anti-inflammatory toothpaste is prepared by the following method:
step one, preparing a nano-scale raw material;
placing 30-50 g of dendrobium officinale extract (containing about 10-15 g of dendrobium officinale flavone, about 10-30 g of dendrobium officinale alkaloid and about 10-20 g of dendrobium officinale phenylpropanoid), 10-20 g of cellulose gum, 15-25 g of tetrasodium phosphate, 8-15 g of sorbitol, 5-10 g of hydrated silica, 40-60 g of water, 50-80 g of tin oxide, 30-60 g of mica and 20-30 g of titanium dioxide in a ball mill, setting the rotating speed of the ball mill to be 500-800 rpm, and polishing for about 2 hours until the extract is polished into a nanoscale mixture to form an aqueous phase solution;
step two, preparing the dendrobium anti-inflammatory toothpaste;
mixing the aqueous phase solution product obtained in the step one with 20-30 g of glycerol, 15-35 g of polyethylene glycol-8, 10-20 g of acesulfame-k, 15-20 g of nano zinc citrate, 8-13 g of sodium lauryl sulfate, 5-15 g of sodium lauroyl sarcosinate, 12-15 g of trichlorogalactose, 8-10 g of sodium benzoate, 3-5 g of corn starch, 2-5 g of microcrystalline cellulose, 7-12 g of essence, 8-10 g of carrageen crispus, 2-4 g of mannitol and 6-9 g of biological phenol acetate, adding the mixture into a cell ultrasonic crusher, and performing ultrasonic dispersion; the power of ultrasonic dispersion is 500-800W, and the ultrasonic dispersion is carried out for 30 minutes; and filling the product after ultrasonic dispersion into bottles to obtain the finished dendrobium anti-inflammatory toothpaste. The dendrobium candidum alkali (molecular formula: C16H25NO2) in the toothpaste is pure alkaloid, has the effects of resisting inflammation, stopping bleeding and reducing swelling, and the dendrobium candidum flavone has the effects of inhibiting bacteria and improving the tooth smoothness; the Dendrobium officinale phenylpropanoid has the effects of resisting oxidation, diminishing inflammation and stopping bleeding.
Embodiment 2, the dendrobium anti-inflammatory toothpaste is prepared by the following method:
step one, preparing a nano-scale raw material;
placing 30 g of dendrobium officinale extract (10 g of dendrobium officinale flavone, 10 g of dendrobium officinale alkaloid and 10 g of dendrobium officinale phenylpropanoid), 10 g of cellulose gum, 15 g of tetrasodium phosphate, 8 g of sorbitol, 5 g of hydrated silica, 40 g of water, 50 g of tin oxide, 30 g of mica and 20 g of titanium dioxide in a ball mill, setting the rotating speed of the ball mill to be 500-800 revolutions per minute, and polishing for about 1 hour until the mixture is polished into a nano-scale mixture to form an aqueous phase solution;
step two, preparing the dendrobium anti-inflammatory toothpaste;
mixing the aqueous phase solution product obtained in the step one with 20 g of glycerol, 15 g of polyethylene glycol-8, 10 g of acesulfame-K, 15 g of nano-zinc citrate, 8 g of sodium lauryl sulfate, 5 g of sodium lauroyl sarcosinate, 12 g of trichlorogalactose, 8 g of sodium benzoate, 3 g of corn starch, 2 g of microcrystalline cellulose, 7 g of essence, 8 g of crinkle moss, 2 g of mannitol and 6 g of biological phenol acetate, adding the mixture into a cell ultrasonic crusher, and performing ultrasonic dispersion; the power of the ultrasonic dispersion is 500W, and the ultrasonic dispersion is carried out for 20 minutes; and filling the product after ultrasonic dispersion into bottles to obtain the finished dendrobium anti-inflammatory toothpaste.
Embodiment 3, the dendrobium anti-inflammatory toothpaste is prepared by the following method:
step one, preparing a nano-scale raw material;
placing 50 g of dendrobium officinale extract (10 g of dendrobium officinale flavone, 30 g of dendrobium officinale alkaloid and 10 g of dendrobium officinale phenylpropanoid), 20 g of cellulose gum, 25 g of tetrasodium phosphate, 15 g of sorbitol, 10 g of hydrated silica, 60 g of water, 80 g of tin oxide, 60 g of mica and 30 g of titanium dioxide in a ball mill, setting the rotating speed of the ball mill to be 500-800 r/min, and polishing for about 2 hours until the mixture is polished into a nano-scale mixture to form an aqueous phase solution;
step two, preparing the dendrobium anti-inflammatory toothpaste;
mixing the aqueous phase solution product obtained in the step one with 30 g of glycerol, 35 g of polyethylene glycol-8, 20 g of acesulfame-K, 20 g of nano-zinc citrate, 13 g of sodium lauryl sulfate, 15 g of sodium lauroyl sarcosinate, 15 g of trichlorogalactose, 10 g of sodium benzoate, 5 g of corn starch, 5 g of microcrystalline cellulose, 12 g of essence, 10 g of wrinkled giant hyssop, 4 g of mannitol and 9 g of biological phenol acetate, adding the mixture into a cell ultrasonic crusher, and performing ultrasonic dispersion; the power of the ultrasonic dispersion is 800W, and the ultrasonic dispersion is carried out for 30 minutes; and filling the product after ultrasonic dispersion into bottles to obtain the finished dendrobium anti-inflammatory toothpaste.
Embodiment 4, the dendrobium anti-inflammatory toothpaste is prepared by the following method:
step one, preparing a nano-scale raw material;
placing 40 g of dendrobium officinale extract (15 g of dendrobium officinale flavone, 15 g of dendrobium officinale alkaloid and 10 g of dendrobium officinale phenylpropanoid), 15 g of cellulose gum, 20 g of tetrasodium phosphate, 10 g of sorbitol, 8 g of hydrated silica, 50 g of water, 60 g of tin oxide, 40 g of mica and 25 g of titanium dioxide in a ball mill, setting the rotating speed of the ball mill to 600 revolutions per minute, and grinding for about 1.5 hours until the extract is ground into a nano-scale mixture to form an aqueous phase solution;
step two, preparing the dendrobium anti-inflammatory toothpaste;
mixing the aqueous phase solution product obtained in the step one with 25 g of glycerol, 20 g of polyethylene glycol-8, 15 g of acesulfame-K, 18 g of nano zinc citrate, 10 g of sodium lauryl sulfate, 10 g of sodium lauroyl sarcosinate, 13 g of trichlorogalactose, 9 g of sodium benzoate, 4 g of corn starch, 3 g of microcrystalline cellulose, 10 g of essence, 9 g of crinkle moss, 3 g of mannitol and 8 g of biological phenol acetate, adding the mixture into a cell ultrasonic crusher, and performing ultrasonic dispersion; the power of the ultrasonic dispersion is 600W, and the ultrasonic dispersion is carried out for 25 minutes; and filling the product after ultrasonic dispersion into bottles to obtain the finished dendrobium anti-inflammatory toothpaste.
In order to better prove the effects of inhibiting bacteria, diminishing inflammation, refreshing breath and improving the oral environment for a long time of the technical scheme of the invention, comparison examples are provided in comparison in some research and development processes of the invention.
Comparative example 1:
the ingredients are basically the same as those in the embodiment 1, but the dendrobium officinale extract is lacked.
Comparative example 2:
the ingredients of the composition are basically the same as those of the embodiment 2, but the dendrobium officinale extract is lacked, and the corresponding components are not ground into a nano shape.
Comparative example 3:
basically has the same components as those of the embodiment 3, but lacks dendrobium officinale extract and nano-grade zinc citrate.
Comparative example 4:
the ingredients of the composition are basically the same as those of the composition in example 4, but the dendrobium officinale extract, the nano-grade zinc citrate and the nano-grade titanium dioxide are lacked.
The toothpastes of examples 1, 2, 3 and 4 and the toothpastes of comparative examples 1, 2, 3 and 4 were randomly administered to 80 volunteers aged 18 to 60 years, who had a tendency to halitosis all the year round, or were susceptible to canker sores, gingival inflammation or toothache. Each person used different toothpastes at the same time every day in different months, after cleaning the oral cavity with the same amount of toothpastes in the corresponding morning or evening, respectively, but used the toothpaste products of different examples and comparative examples, respectively. The time for brushing teeth is 5 minutes. After brushing, the oral and dental status of the user was observed and evaluated at random and questionnaires were performed.
The toothpastes of examples 1, 2, 3 and 4 and comparative examples 1, 2, 3 and 4 were used continuously for 7 days, respectively; after 56 days in total, the statistical survey results show the following (evaluated from 6 aspects such as fire dispelling effect, anti-inflammatory and detumescence effect, breath freshening effect, anti-inflammatory and analgesic effect, allergy and the like, and respectively scored as very excellent, good, poor and extremely poor):
during the using period of the product in the embodiment 1, fresh breath, obvious improvement of halitosis, good fire-dispelling effect, pain-relieving effect and no allergy are generally considered.
During the using period of the product in the embodiment 2, the oral environment is generally considered to be improved, the breath clearing effect is obvious, the pain relieving effect can be kept for a long time, and no allergy exists.
In the using period of the product of the embodiment 3, the fire dispelling effect is generally considered to be good, the tooth whitening effect is good, fresh breath can be kept for a long time, and no allergy exists.
The group using the product of the embodiment 4 generally considers that the product has good fire-dispelling effect, better prevents or relieves the oral ulcer, can play a role in diminishing inflammation and relieving pain for a long time, and has no allergy.
The group using the product of comparative example 1 is generally regarded as having no effect of dispelling fire, short period of relieving pain, common others and no allergy.
The group using the product of comparative example 2 generally believes that the mouth wash cannot achieve the effects of relieving pain, eliminating fire, relieving canker sore and causing no allergy.
The group using the product of comparative example 3 was widely regarded as not improving the oral environment, having little effect of improving the oral odor, and having no allergy.
The group using the product of comparative example 4 generally believes that the oral environment cannot be improved, the oral odor is hardly improved, the whitening effect on teeth is hardly achieved, and neither allergy is caused.
Therefore, the dendrobium officinale extract is reasonable in formula, and due to the fact that the dendrobium officinale extract has extremely strong viscosity, effective anti-inflammatory and antibacterial ingredients in the dendrobium officinale extract can be adsorbed on teeth, gums and oral intima together, and cannot be washed away by mouth wash even after tooth brushing is carried out, so that the dendrobium officinale extract can play a role in inhibiting bacteria, diminishing inflammation, eliminating peculiar smell and promoting healing of fine oral wounds for a long time. The dendrobium officinale adopted by the invention has the effects of tonifying qi and promoting the production of body fluid, nourishing yin and removing heat, reducing swelling and promoting granulation, and dredging collaterals and relieving pain, and can obviously prevent and improve symptoms of oral ulcer, gum swelling and pain, bleeding and halitosis. Meanwhile, the raw materials of the toothpaste are made of the nano-grade powder, so that the effective antibacterial and anti-inflammatory components can be effectively adsorbed in the oral cavity in a free manner, and the time effects of the toothpaste, such as anti-inflammation, sterilization and pain relieving, are greatly enhanced; it can clean the oral cavity for 24 hours, and then the user keeps the breath in the oral cavity fresh. The invention adopts nano titanium dioxide as an efficient and nontoxic photocatalyst, and the nano titanium dioxide can play a role in whitening teeth when being used in toothpaste. The zinc citrate adopted by the invention can effectively improve the flora in the oral cavity, thereby playing the roles of cleaning the oral cavity and refreshing the breath.
Claims (9)
1. The dendrobium anti-inflammatory toothpaste is characterized by comprising the following components in parts by weight:
2. the dendrobium anti-inflammatory toothpaste as claimed in claim 1, which is characterized by further comprising the following components in parts by weight: the herba Dendrobii extract contains herba Dendrobii flavone, Dendrobium candidum alkali, and herba Dendrobii phenylpropanoid.
3. The dendrobium anti-inflammatory toothpaste as claimed in claim 2, characterized by further comprising the following components in parts by weight:
4. the dendrobium anti-inflammatory toothpaste according to claim 3, characterized by further comprising the following components in parts by weight:
5. the dendrobe anti-inflammatory toothpaste according to claim 4, which is characterized by further comprising the following components in parts by weight:
6. the dendrobium anti-inflammatory toothpaste as claimed in claim 5, characterized by further comprising the following components in parts by weight:
2-4 parts of mannitol
6-9 parts of biological phenol acetate.
7. The preparation method of the dendrobium anti-inflammation toothpaste is characterized by comprising the following steps:
step one, preparing a nano-scale raw material;
placing the dendrobium officinale extract, cellulose gum, tetrasodium phosphate, sorbitol, hydrated silica, water, tin oxide, mica and titanium dioxide into a ball mill, setting the rotating speed of the ball mill to be 500-800 rpm, and polishing for 1-2 hours to form an aqueous phase solution;
step two, preparing the dendrobium anti-inflammatory toothpaste;
mixing the water phase solution product obtained in the step one with glycerol, polyethylene glycol-8, acesulfame-K, nano-zinc citrate, sodium lauryl sulfate, sodium lauroyl sarcosinate, trichlorogalactose, sodium benzoate, corn starch, microcrystalline cellulose, essence, Chondrus crispus, mannitol and biological phenol acetate, adding into a cell ultrasonic crusher, and performing ultrasonic dispersion; the power of ultrasonic dispersion is 500-800W, and the ultrasonic dispersion is carried out for 30 minutes; and filling the product after ultrasonic dispersion into bottles to obtain the finished dendrobium anti-inflammatory toothpaste.
8. The dendrobe anti-inflammatory toothpaste as claimed in claim 7, wherein the tin oxide, mica and titanium dioxide in the first step are all polished into a nano shape.
9. The dendrobium anti-inflammatory toothpaste according to claim 8, wherein the components in the first step and the second step are as follows in parts by weight: 30-50 parts of dendrobium officinale extract, 10-20 parts of cellulose gum, 15-25 parts of tetrasodium pyrophosphate, 8-15 parts of sorbitol, 5-10 parts of hydrated silica, 40-60 parts of water, 50-80 parts of tin oxide, 30-60 parts of mica, 20-30 parts of titanium dioxide, 20-30 parts of glycerol, 15-35 parts of polyethylene glycol-8, 10-20 parts of butyl-sulfanilamide, 15-20 parts of zinc citrate, 8-13 parts of sodium lauryl sulfate, 5-15 parts of sodium lauroyl sarcosinate, 12-15 parts of trichlorogalactose, 8-10 parts of sodium benzoate, 3-5 parts of corn starch, 2-5 parts of microcrystalline cellulose, 7-12 parts of essence, 8-10 parts of curdlan, 2-4 parts of mannitol and 6-9 parts of biological phenol acetate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110979510.8A CN113576995A (en) | 2021-08-25 | 2021-08-25 | Dendrobium anti-inflammation toothpaste and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127340A (en) * | 2014-07-23 | 2014-11-05 | 浙江森宇实业有限公司 | Dendrobium officinale toothpaste and preparation method |
| CN106038425A (en) * | 2016-07-26 | 2016-10-26 | 宁波圣旺生物科技有限公司 | Herba Dendrobii toothpaste and preparation method thereof |
| CN106063776A (en) * | 2016-05-31 | 2016-11-02 | 安徽皖斛堂生物科技有限公司 | A kind of Herba Dendrobii toothpaste and preparation method thereof |
| CN110575414A (en) * | 2018-06-08 | 2019-12-17 | 广州医家仁生物科技有限责任公司 | Chinese herbal medicine plant oral cavity maintenance composition and preparation method and use method thereof |
-
2021
- 2021-08-25 CN CN202110979510.8A patent/CN113576995A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127340A (en) * | 2014-07-23 | 2014-11-05 | 浙江森宇实业有限公司 | Dendrobium officinale toothpaste and preparation method |
| CN106063776A (en) * | 2016-05-31 | 2016-11-02 | 安徽皖斛堂生物科技有限公司 | A kind of Herba Dendrobii toothpaste and preparation method thereof |
| CN106038425A (en) * | 2016-07-26 | 2016-10-26 | 宁波圣旺生物科技有限公司 | Herba Dendrobii toothpaste and preparation method thereof |
| CN110575414A (en) * | 2018-06-08 | 2019-12-17 | 广州医家仁生物科技有限责任公司 | Chinese herbal medicine plant oral cavity maintenance composition and preparation method and use method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘湘: "一种具有消炎作用的牙膏" * |
| 奚航献等: "铁皮石斛化学成分、药理作用及其质量标志物（Q-marker）的预测分析" * |
| 陈晓梅;王春兰;杨峻山;郭顺星;: "铁皮石斛化学成分及其分析的研究进展" * |
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