CN105878124A - Radix tetrastigme toothpaste and preparation method thereof - Google Patents
Radix tetrastigme toothpaste and preparation method thereof Download PDFInfo
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- CN105878124A CN105878124A CN201610385214.4A CN201610385214A CN105878124A CN 105878124 A CN105878124 A CN 105878124A CN 201610385214 A CN201610385214 A CN 201610385214A CN 105878124 A CN105878124 A CN 105878124A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
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Abstract
The invention discloses radix tetrastigme toothpaste and a preparation method thereof. The toothpaste is prepared from, by weight, 3.4-17.8 parts of mixed wall breaking stock solution, xanthan gum, carrageenan and other toothpaste body matrixes. The mixed wall breaking stock solution is prepared from, by weight, 3-15 parts of fresh radix tetrastigme, 0.3-2 parts of green tea leaves and 0.1-0.8 part of pseudo-ginseng. Spectral sterilization, ultralow constant temperature vibration type wall breaking micro smashing and other modes are adopted in the toothpaste for obtaining the mixed wall breaking stock solution, and the cell wall breaking rate reaches 98.5 or above. Meanwhile, under the condition of temperature control, the toothpaste is prepared by combing the stock solution and the toothpaste body matrixes. The ultralow constant temperature vibration type wall breaking micro smashing mode is adopted, and the mixed wall breaking stock solution with the optimal drug property can be obtained under the condition of temperature control and can be fully fused into the toothpaste, so that the utilization rate of medicinal materials is increased, the additional value of the medicine materials is improved, the effects of the toothpaste on dental ulcers, periodontitis, bleeding gums and other oral diseases are better than those of common medicine toothpaste, and tooth health is benefited better.
Description
Technical field
The present invention relates to a kind of toothpaste and preparation method thereof, especially relate to a kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste and preparation method.
Background technology
Radix Apioris Fortunei (Radix Lespedezae Buergeri), Radix Notoginseng, green tea brief introduction and the effect for oral disease thereof.
The Ji Yuan of Radix Apioris Fortunei (Radix Lespedezae Buergeri) is Vitaceae Tetrastigma plant tetratigma hemsleyanum Tetrastigma hemsleyanum
Diels et.Gilg.Different name is Radix Tetrastigmatis Hemsleyani " Zhiwu Mingshi Tukao ", Shi Baozi " Jiangxi medical herbs ", gold thread hoist, SANYE pair
" Zhejiang conventional medical herbs among the people ", little Caulis et Radix Tetrastigmatis Planicaulis, SANYE Caulis et Radix Tetrastigmatis Planicaulis, block mountain tiger " Guangxi practicality Chinese herbal medicine newly selects ", thunder courage " Hunan medium-height grass
Medicine new therapy that combines both Chinese and Western medical practices data is selected and compile ".Its property of Radix Apioris Fortunei (Radix Lespedezae Buergeri) is flat, mildly bitter flavor, has the effects such as heat-clearing and toxic substances removing, dispelling pathogenic wind and eliminating phlegm, promoting blood circulation and stopping pain.
It is safety non-toxic that Radix Apioris Fortunei (Radix Lespedezae Buergeri) is eaten for a long time, its have regulate the flow of vital energy, spleen invigorating, effect of appetizing, moreover it is possible to improve immunity function.SANYE
Green grass or young crops can strengthen human immunity, not only can improve cellular immunization, also improves humoral immunization, i.e. promotes that interferon, interleukin are raw
Become, induced tumor necrosin.Cure mainly venom, tonsillitis, tuberculous lymphadenitis, traumatic injury, children with high fever induced convulsions etc.
Disease, is Western medicine " bouvardin " that cannot replace.The active ingredient being had by Radix Apioris Fortunei (Radix Lespedezae Buergeri) adds in toothpaste, for oral cavity
In can suppress bacterial reproduction, effectively prevent halitosis, can reach anti-inflammation and sterilization, the effect of fresh breath.In addition, also may be used
With hemostasia and detumescence；Strengthen cellular immune function etc..
Radix Notoginseng, has another name called literary composition state Radix Notoginseng, for panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen's
Dry root and rhizome.Property hardship sweet, micro-, temperature.Effect dissipating blood stasis stops blooding, subduing swelling and relieving pain.Radix Notoginseng contains Radix Notoginseng total arasaponins, and it is antibacterial disappears
Inflammation, analgesic activity are clear and definite, and additionally hemostasis is mainly composed of dencichine.Through effect experiment and other clinical proofs, containing Radix Notoginseng
The toothpaste of composition is evident in efficacy to gingivitis, dental hemorrhage, oral ulcer etc..
Green tea is the good merchantable brand being commonly used to during we live receive guests, and there is long tea culture history in China.Correlational study is reported
Thinking, catechin, theaflavin and phenol in Folium Camelliae sinensis have notable antibacterial action to enteritis pathogenic bacteria, to Staphylococcus aureus, typhoid fever bar
The multiple malignant bacteria such as bacterium also has obvious inhibitory action.Tea polyphenolic compounds can kill the pathogen in slot, the most right
The protected effect of tooth, and removable halitosis.It is made through effect experiment and other clinical proof green tea interpolations
Toothpaste has fresh breath and significant tooth protection is good for tooth effect.
Following defect is there is in the market in preparation about Radix Apioris Fortunei (Radix Lespedezae Buergeri) breaking cellular wall stock solution:
1. Radix Apioris Fortunei (Radix Lespedezae Buergeri) breaking cellular wall stock solution is in preparation process, the most easily loses drug effect, causes Radix Apioris Fortunei (Radix Lespedezae Buergeri) series of products
Medical value is the highest.
Radix Apioris Fortunei (Radix Lespedezae Buergeri) fresh goods preparation technology is the best the most in the market, and cell-wall breaking ratio is low, causes the utilization rate that medical material is overall
Low, added value is low.
Summary of the invention
It is an object of the invention to provide a kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste and preparation method, mixing breaking cellular wall stock solution use spectrum sterilization,
Prepared by the ultralow constant temperature vibration modes such as pulverizing that decline, mixing stock solution is made up of Radix Apioris Fortunei (Radix Lespedezae Buergeri), green tea, Radix Notoginseng；Mixing breaking cellular wall stock solution
Cell-wall breaking ratio reach more than 98.5%, keep mixing breaking cellular wall stock solution drug effect optimal under temperature control, and fully incorporate toothpaste
In.Just can get a desired effect with less dosage so that the utilization rate of medical material is maximum, also increase its added value simultaneously.
The present invention solves the technical scheme that above-mentioned technical problem used: a kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste, by following weight portion
The raw material of number is made: Pyrusussuriensis (sugared) alcohol 20-37 part, hydrated silica 8-22 part, mixing breaking cellular wall stock solution 3.4-17.8 part, poly-second two
Alcohol-400 1-8 part, sodium lauryl sulfate 0.8-5 part, edible essence 0.05-4 part, xanthan gum 0.1-2 part, carrageenan 0.05-
1 part, cocamido propyl betaine 0.03-1 part, saccharin sodium 0.01-1 part, methyl hydroxybenzoate 0.01-1 part, remaining number be ultrapure
Water.
Further, described toothpaste is by following component by weight: Pyrusussuriensis (sugared) alcohol 22-35 part, hydration silicon
Stone 10-20 part, mixing breaking cellular wall stock solution 5-16.8 part, PEG-4000 2-7 part, sodium lauryl sulfate 0.9-4.5 part, food
With essence 0.08-3.95 part, xanthan gum 0.2-1.8 part, carrageenan 0.07-0.9 part, cocamido propyl betaine 0.04-
0.98 part, saccharin sodium 0.03-0.98 part, methyl hydroxybenzoate 0.02-0.52 part, remaining number be ultra-pure water.
Further, described toothpaste is by following component by weight: Pyrusussuriensis (sugared) alcohol 28-35 part, hydration silicon
Stone 15-20 part, mixing breaking cellular wall stock solution 6-14.2 part, PEG-4000 2.5-6 part, sodium lauryl sulfate 1.2-4.3 part,
Edible essence 0.1-3.5 part, xanthan gum 0.3-1.5 part, carrageenan 0.2-0.5 part, cocamido propyl betaine 0.15-0.5
Part, saccharin sodium 0.1-0.5 part, methyl hydroxybenzoate 0.3-0.52 part, remaining number are ultra-pure water.
Further, described toothpaste is by following component by weight: Pyrusussuriensis (sugared) alcohol 35 parts, hydrated silica 20
Part, mixing breaking cellular wall stock solution 11.5 parts, PEG-4000 5 parts, sodium lauryl sulfate 3 parts, edible essence 2 parts, xanthan gum 1
Part, carrageenan 0.3 part, cocamido propyl betaine 0.3 part, saccharin sodium 0.2 part, methyl hydroxybenzoate 0.5 part, remaining number are super
Pure water.
Further, mixing breaking cellular wall stock solution is made up of Radix Apioris Fortunei (Radix Lespedezae Buergeri), green tea, Radix Notoginseng, and it is fresh that three's weight is respectively Radix Apioris Fortunei (Radix Lespedezae Buergeri)
Product 3-15 part, green tea 0.3-2 part, Radix Notoginseng 0.1-0.8 part.
Further, the parts by weight of mixing breaking cellular wall stock solution are by Radix Apioris Fortunei (Radix Lespedezae Buergeri) fresh goods 10 parts, green tea 0.9 part, Radix Notoginseng 0.6 part
Constitute.
Further, the preparation of described mixing breaking cellular wall stock solution comprises the following steps:
Step one:
The sorting of a, Radix Apioris Fortunei (Radix Lespedezae Buergeri) is cleaned；
B, spectrum sterilizing 5-10 minute；
C, roughing cutting machine shred, and obtain cutting off thing, and are placed under spectrum sterilized environment stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, spectrum sterilizing 5-10 minute；
C, roughing cutting machine shred, and obtain cutting off thing, and are placed under spectrum sterilized environment stand-by；
Step 3:
A, sterilization step one and step 2 obtained cut-out thing and Radix Notoginseng all insert the broken machine of vibration type wall-broken micro powder, this vibration type
The broken machine of wall-broken micro powder is aseptic condition；
B, interpolation ultra-pure water, medicine and water ratio are within 1:1.4；
C, to carry out ultralow constant temperature vibration formula wall-broken micro powder broken, produces mixing breaking cellular wall stock solution, cell under temperature is for-2 DEG C (± 0.1)
Sporoderm-broken rate reaches 98.5%；
D, the spectrum sterilization of mixing breaking cellular wall stock solution elder generation is inserted again cryogenic sterile seal container preserves stand-by, in described sealing container
Storage temperature be-2 DEG C-0 DEG C.
Further, the preparation technology of described toothpaste comprises the following steps:
Step one: by the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate in temperature
Being to carry out homogenizing stirring under the constant temperature of 95 DEG C-120 DEG C, mixing time is 10-20 minute, obtains the first stirring thing；
Step 2:
A, the first stirring thing step one obtained are poured into and are stirred in de-airing mixer and cool down, and are cooled to 50 DEG C-75 DEG C；
When b, liter high-temperature are to 60 DEG C-80 DEG C, add the xanthan gum of formula ratio, carrageenan, edible essence；
C, again temperature is increased to 90 DEG C-95 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Pyrusussuriensis
(sugared) alcohol；
D, unlatching vacuum pump, holding pressure is at-0.5MPa～-0.1MPa, and constant temperature high speed is continuously stirred, and mixing speed is every point
Clock 2000-3000 turns, and mixing time is 15-20 minute, obtains the second stirring thing；
Step 3: the second stirring thing step 2 obtained cools down in inserting cream pot processed, and chilling temperature is 60 DEG C-75 DEG C, in temperature
When degree reaches 75 DEG C-85 DEG C, add the mixing breaking cellular wall stock solution of claim 7 preparation of formula ratio, carry out Quick uniform stirring, stir
The time of mixing is 5 minutes, obtains the 3rd stirring thing；
Step 4: lowered the temperature rapidly by the stirring thing of the 3rd stirring thing obtained in step 3, temperature fall time is 59 seconds, temperature decrease
To 25 DEG C-26 DEG C；
Step 5: placing ageing, the temperature of this ageing is 20 DEG C-30 DEG C；
Step 6: Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste is carried out fill.
Compared with prior art, the present invention has the following advantages and effect: the present invention uses spectrum sterilization, ultralow constant temperature to shake
The preparation method that dynamic formula wall-broken micro powder is broken, obtains Radix Apioris Fortunei (Radix Lespedezae Buergeri), green tea, the breaking cellular wall stock solution of Radix Notoginseng three mixing, cell-wall breaking ratio
Reach more than 98.5%, be a kind of technical breakthrough for single Chinese herbal medicine grinding mode, improve the utilization of medical material
Rate, increase its added value.The present invention uses temperature controlled method, produces mixing breaking cellular wall former under temperature is for-2 DEG C (± 0.1)
Liquid ,-2 DEG C of-0 DEG C of cryopreservation, temperature indirect type improves and carries out lotion of toothpaste substrate stirring, finally quick when 75 DEG C-85 DEG C
Lotion of toothpaste substrate is sufficiently mixed with mixing breaking cellular wall stock solution and is cooled to rapidly room temperature in 59 seconds.Described temperature-controlled process is protected
Card breaks while not losing wall stock solution drug effect, and the drug effect that Radix Apioris Fortunei (Radix Lespedezae Buergeri), Radix Notoginseng, green tea mix is optimal, and anti-inflammation and sterilization is effective,
More effective than general medicated toothpaste for oral diseases such as oral ulcer, periodontitis, gingival hemorrhages, it is more beneficial for dental health,
The present invention, through many experiments, draws preferred plan, and temperature controls optimal, and utilization ratio of drug rises to the highest, reasonable in design, symbol
Close the market demand, be suitable for promoting.
Applicant carried out following experiments, the provable present invention has effective effect
Test 1. Radix Apioris Fortunei (Radix Lespedezae Buergeri) breaking cellular wall stock solutions to antibacterial minimum inhibitory concentration
Experiment material
The Radix Apioris Fortunei (Radix Lespedezae Buergeri) breaking cellular wall that in fluid medium, centrifuge tube, the present invention, the ultralow constant temperature vibration broken mode of formula wall-broken micro powder obtains is former
Liquid, Radix Apioris Fortunei (Radix Lespedezae Buergeri) rotate micropowder breaking cellular wall stock solution, test organisms etc..
Experimental technique
By fluid medium and centrifuge tube in 121 DEG C of sterilizing 20 min, after cooling, each in test tube add 0.5 mL liquid culture
Base, according to doubling dilution, Radix Apioris Fortunei (Radix Lespedezae Buergeri) breaking cellular wall stock solution doubling dilution joins 2.5 mg/mL, 2 mg/mL, 1.5 mg/mL, 1.25
Mg/mL, 1 mg/mL, 0.75 mg/mL, 0.625 mg/mL and 0.3125 mg/mL.The often corresponding test organisms of each addition in group test tube
0.1 mL, shakes up.Test tube is placed in 37 DEG C of constant incubators and cultivates 24 h, observe bacterial growth situation.
Experimental result
Experiment terminates the growing state analysis of antibacterial in rear test tube and draws table 1 result
Table 1 Radix Apioris Fortunei (Radix Lespedezae Buergeri) breaking cellular wall stock solution is to antibacterial minimum inhibitory concentration (mg/ml)
| Bacterial species | Condition of culture | Radix Apioris Fortunei (Radix Lespedezae Buergeri) vibration micropowder breaking cellular wall stock solution | Radix Apioris Fortunei (Radix Lespedezae Buergeri) rotates micropowder breaking cellular wall stock solution |
| Glutinous actinomycetes | (A) | 0.625 | 0.75 |
| Gingival carbon dioxide is addicted to cellulose bacteria | (A) | 0.3125 | 0.50 |
| Pseudomonas fluorescens | (A) | 0.625 | 0.75 |
| Porphyromonas single-cell bacteria | (AN) | 1.25 | 1.50 |
| Porphyromonas antibacterial | (AN) | 1.25 | 1.25 |
| Actinomyces naeslundii | (AN) | 1.0 | 1.25 |
| Fusobacterium nucleatum | (AN) | 1.0 | 1.25 |
| Bacterium actinomycetem comitans | (AN) | 0. 25 | 0.3125 |
Note: (A) aerobic conditions, (AN) oxygen free condition.
Conclusion
As shown in Table 1, the Radix Apioris Fortunei (Radix Lespedezae Buergeri) breaking cellular wall stock solution that in the present invention, the ultralow constant temperature vibration broken mode of formula wall-broken micro powder obtains is for glutinous
Actinomycetes, gingival carbon dioxide are strong addicted to the inhibitory action of the antibacterials such as cellulose bacteria.Illustrate by constant temperature vibration ultralow in the present invention
Radix Apioris Fortunei (Radix Lespedezae Buergeri) that the broken mode of formula wall-broken micro powder obtains, Radix Notoginseng, the green tea mixing effective dissolution rate of stock solution are high, strong drug action, bactericidal antiphlogistic
Effect more preferably.
Test 2. Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste xylol and cause the impact of mice auricle swelling
Experiment material
The ultralow constant temperature vibration broken side of formula wall-broken micro powder in female rats 40, dimethylbenzene, the Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste of the present invention, the present invention
Formula obtains Radix Apioris Fortunei (Radix Lespedezae Buergeri) breaking cellular wall stock solution, Radix Apioris Fortunei (Radix Lespedezae Buergeri) rotates micropowder breaking cellular wall stock solution.
Experimental technique
Taking female rats 40, be randomly divided into 4 groups, often group 10, gives corresponding external dimethylbenzene uniform in each treated animal auricle
Smear (consumption 0.1ml), to cause inflammatory reaction.It is blank group (water, 30ml/kg), Radix Apioris Fortunei (Radix Lespedezae Buergeri) tooth after causing scorching latter 1 hour
Cream (1.38 g/kg are equivalent to fresh medical material 0.8 g/kg), Radix Apioris Fortunei (Radix Lespedezae Buergeri) vibration micropowder breaking cellular wall stock solution (0.14 g/kg), Radix Apioris Fortunei (Radix Lespedezae Buergeri)
Rotate micropowder breaking cellular wall stock solution (1.00g/kg) and smear auris dextra exterior feature.Mice takes off after smearing 1 hour cervical vertebra put to death, by auricle right, left
Cutting, make round auricle (diameter 9 mm), analytical balance is weighed, every animal auricle weight difference right, left, i.e. reflection inflammation swelling
Degree.Between many groups, mean compares employing variance analysis, and all data process with by SPSS 17.0 statistical software.
Experimental result
The inflammation swelling degree analyzing data of each sample mice are as shown in table 2
Table 2 Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste xylol causes the impact of mice auricle swelling
| Group | Dosage (/kg) | n | Interaural difference value (mg) | Suppression ratio (%) |
| Blank | — | 10 | 9.06 ± 2.41 | — |
| Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste | 1.38 g | 10 | 6.13 ± 2.58 | 32.3 |
| Radix Apioris Fortunei (Radix Lespedezae Buergeri) vibration micropowder breaking cellular wall stock solution | 0.54 g | 10 | 5.86 ± 2.36 | 35.3 |
| Radix Apioris Fortunei (Radix Lespedezae Buergeri) rotates micropowder breaking cellular wall stock solution | 1.00g | 10 | 6.55 ± 2.23 | 31.3 |
Conclusion
As shown in Table 2, in the Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste of the present invention and the present invention, the ultralow constant temperature vibration broken mode of formula wall-broken micro powder obtains three
Leaf green grass or young crops breaking cellular wall stock solution suppression ratio is higher, illustrates that breaking cellular wall stock solution fully incorporates in toothpaste, and detumescence effect is more preferable.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, and following example are the solutions to the present invention
Release, and the invention is not limited in following example.
Embodiment 1:
Formula: Pyrusussuriensis (sugared) alcohol 20 parts, hydrated silica 8 parts, mixing breaking cellular wall stock solution 3.4 parts, PEG-4000 1 part, lauryl alcohol
Sodium sulfovinate 0.8 part, edible essence 0.05 part, xanthan gum 0.1 part, carrageenan 0.05 part, cocamido propyl betaine 0.03
Part, saccharin sodium 0.01 part, methyl hydroxybenzoate 0.01 part, remaining number are ultra-pure water.
The composition of described mixing breaking cellular wall stock solution is made up of Radix Apioris Fortunei (Radix Lespedezae Buergeri), green tea, Radix Notoginseng, and it is fresh that parts by weight are respectively Radix Apioris Fortunei (Radix Lespedezae Buergeri)
Product 3 parts, green tea 0.3 part, Radix Notoginseng 0.1 part, the preparation of this mixing breaking cellular wall stock solution includes following technique:
Step one:
The sorting of a, Radix Apioris Fortunei (Radix Lespedezae Buergeri) is cleaned；
B, spectrum sterilizing 5-10 minute；
C, roughing cutting machine shred, and obtain cutting off thing, and are placed under spectrum sterilized environment stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, spectrum sterilizing 5-10 minute；
C, roughing cutting machine shred, and obtain cutting off thing, and are placed under spectrum sterilized environment stand-by；
Step 3:
A, sterilization step one and step 2 obtained cut-out thing and Radix Notoginseng all insert the broken machine of vibration type wall-broken micro powder, this vibration type
The broken machine of wall-broken micro powder is aseptic condition；
B, interpolation ultra-pure water, medicine and water ratio are within 1:1.4；
C, to carry out ultralow constant temperature vibration formula wall-broken micro powder broken, produces mixing breaking cellular wall stock solution, cell under temperature is for-2 DEG C (± 0.1)
Sporoderm-broken rate reaches 98.5%；
D, the spectrum sterilization of mixing breaking cellular wall stock solution elder generation is inserted again cryogenic sterile seal container preserves stand-by, in described sealing container
Storage temperature be-2 DEG C-0 DEG C.
Described Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste making process:
Step one: by the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate in temperature
Being to carry out homogenizing stirring under the constant temperature of 95 DEG C-120 DEG C, mixing time is 10-20 minute, obtains the first stirring thing；
Step 2:
A, the first stirring thing step one obtained are poured into and are stirred in de-airing mixer and cool down, and are cooled to 50 DEG C-75 DEG C；
When b, liter high-temperature are to 60 DEG C-80 DEG C, add the xanthan gum of formula ratio, carrageenan, edible essence；
C, again temperature is increased to 90 DEG C-95 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Pyrusussuriensis
(sugared) alcohol；
D, unlatching vacuum pump, holding pressure is at-0.5MPa～-0.1MPa, and constant temperature high speed is continuously stirred, and mixing speed is every point
Clock 2000-3000 turns, and mixing time is 15-20 minute, obtains the second stirring thing；
Step 3: the second stirring thing step 2 obtained cools down in inserting cream pot processed, and chilling temperature is 60 DEG C-75 DEG C, in temperature
When degree reaches 75 DEG C-85 DEG C, add the mixing breaking cellular wall stock solution of claim 7 preparation of formula ratio, carry out Quick uniform stirring, stir
The time of mixing is 5 minutes, obtains the 3rd stirring thing；
Step 4: lowered the temperature rapidly by the stirring thing of the 3rd stirring thing obtained in step 3, temperature fall time is 59 seconds, temperature decrease
To 25 DEG C-26 DEG C；
Step 5: placing ageing, the temperature of this ageing is 20 DEG C-30 DEG C；
Step 6: Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste is carried out fill.
Embodiment 2:
Formula: Pyrusussuriensis (sugared) alcohol 37 parts, hydrated silica 22 parts, mixing breaking cellular wall stock solution 17.8 parts, PEG-4000 8 parts, Laurel
Alcohol sodium sulfovinate 5 parts, edible essence 4 parts, xanthan gum 2 parts, carrageenan 1 part, cocamido propyl betaine 1 part, saccharin sodium 1
Part, methyl hydroxybenzoate 1 part, remaining number are ultra-pure water；
The composition of described mixing breaking cellular wall stock solution is made up of Radix Apioris Fortunei (Radix Lespedezae Buergeri), green tea, Radix Notoginseng, and parts by weight are respectively Radix Apioris Fortunei (Radix Lespedezae Buergeri) fresh goods 15
Part, green tea 2 parts, Radix Notoginseng 0.8 part, the preparation technology of this mixing breaking cellular wall stock solution is with reference to the system of the mixing breaking cellular wall stock solution of embodiment 1
Preparation Method.
Described Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste making process is with reference to the Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste making process of embodiment 1.
Embodiment 3:
Formula: Pyrusussuriensis (sugared) alcohol 35 parts, hydrated silica 20 parts, mixing breaking cellular wall stock solution 11.5 parts, PEG-4000 5 parts, Laurel
Alcohol sodium sulfovinate 3 parts, edible essence 2 parts, xanthan gum 1 part, carrageenan 0.3 part, cocamido propyl betaine 0.3 part, saccharin
0.2 part of sodium, methyl hydroxybenzoate 0.5 part, remaining number are ultra-pure water.
The composition of described mixing breaking cellular wall stock solution is made up of Radix Apioris Fortunei (Radix Lespedezae Buergeri), green tea, Radix Notoginseng, and it is fresh that parts by weight are respectively Radix Apioris Fortunei (Radix Lespedezae Buergeri)
Product 10 parts, green tea 0.9 part, Radix Notoginseng 0.6 part, the preparation technology of this mixing breaking cellular wall stock solution is former with reference to the mixing breaking cellular wall of embodiment 1
The preparation method of liquid.
Described Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste making process is with reference to the Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste making process of embodiment 1.
The present invention uses the preparation method that spectrum sterilization, ultralow constant temperature vibration formula wall-broken micro powder are broken, obtains Radix Apioris Fortunei (Radix Lespedezae Buergeri), green tea
Leaf, the breaking cellular wall stock solution of Radix Notoginseng three mixing, cell-wall breaking ratio reaches more than 98.5%, for single Chinese herbal medicine grinding mode
It is a kind of technical breakthrough, improves the utilization rate of medical material, increase its added value.The present invention uses temperature controlled method,
Producing mixing breaking cellular wall stock solution ,-2 DEG C of-0 DEG C of cryopreservation under temperature is for-2 DEG C (± 0.1), temperature indirect type improves and carries out toothpaste
Ointment bases stirs, and finally quickly lotion of toothpaste substrate is sufficiently mixed and 59 seconds with mixing breaking cellular wall stock solution when 75 DEG C-85 DEG C
It is cooled to the most rapidly room temperature.Described temperature-controlled process ensure broken do not lose wall stock solution drug effect while, Radix Apioris Fortunei (Radix Lespedezae Buergeri), Radix Notoginseng, green
The drug effect that tea mixes is optimal, and anti-inflammation and sterilization is effective, for oral disease ratios such as oral ulcer, periodontitis, gingival hemorrhages
General medicated toothpaste is effective, is more beneficial for dental health, and the present invention, through many experiments, draws preferred plan, and temperature controls
Most preferably, utilization ratio of drug rises to the highest, reasonable in design, accords with the demands of the market, and is suitable for promoting.
The foregoing describe principal character and the advantage of the present invention, although it is open as above that the present invention has been carried out example, but it is not
In order to limit protection scope of the present invention, any technical staff being familiar with this technology, without departing from the design of the present invention and model
Enclose interior made change and retouching, protection scope of the present invention all should be belonged to.
Claims (8)
1. a Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste, it is characterised in that: it is made up of the raw material of following parts by weight: Pyrusussuriensis (sugared) alcohol 20-37 part,
Hydrated silica 8-22 part, mixing breaking cellular wall stock solution 3.4-17.8 part, PEG-4000 1-8 part, sodium lauryl sulfate 0.8-5
Part, edible essence 0.05-4 part, xanthan gum 0.1-2 part, carrageenan 0.05-1 part, cocamido propyl betaine 0.03-1 part,
Saccharin sodium 0.01-1 part, methyl hydroxybenzoate 0.01-1 part, remaining number are ultra-pure water.
A kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste the most according to claim 1, it is characterised in that described toothpaste by following component according to weight
Number forms: Pyrusussuriensis (sugared) alcohol 22-35 part, hydrated silica 10-20 part, mixing breaking cellular wall stock solution 5-16.8 part, PEG-4000
2-7 part, sodium lauryl sulfate 0.9-4.5 part, edible essence 0.08-3.95 part, xanthan gum 0.2-1.8 part, carrageenan 0.07-
0.9 part, cocamido propyl betaine 0.04-0.98 part, saccharin sodium 0.03-0.98 part, methyl hydroxybenzoate 0.02-0.52 part, remaining
Lower number is ultra-pure water.
A kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste the most according to claim 1, it is characterised in that described toothpaste by following component according to weight
Number forms: Pyrusussuriensis (sugared) alcohol 28-35 part, hydrated silica 15-20 part, mixing breaking cellular wall stock solution 6-14.2 part, PEG-4000
2.5-6 part, sodium lauryl sulfate 1.2-4.3 part, edible essence 0.1-3.5 part, xanthan gum 0.3-1.5 part, carrageenan 0.2-
0.5 part, cocamido propyl betaine 0.15-0.5 part, saccharin sodium 0.1-0.5 part, methyl hydroxybenzoate 0.3-0.52 part, remaining part
Number is ultra-pure water.
A kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste the most according to claim 1, it is characterised in that described toothpaste by following component according to weight
Number forms: Pyrusussuriensis (sugared) alcohol 35 parts, hydrated silica 20 parts, mixing breaking cellular wall stock solution 11.5 parts, PEG-4000 5 parts, Laurel
Alcohol sodium sulfovinate 3 parts, edible essence 2 parts, xanthan gum 1 part, carrageenan 0.3 part, cocamido propyl betaine 0.3 part, saccharin
0.2 part of sodium, methyl hydroxybenzoate 0.5 part, remaining number are ultra-pure water.
5. according to a kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste described in Claims 1-4, it is characterised in that mixing breaking cellular wall stock solution by Radix Apioris Fortunei (Radix Lespedezae Buergeri),
Green tea, Radix Notoginseng composition, three's weight is respectively Radix Apioris Fortunei (Radix Lespedezae Buergeri) fresh goods 3-15 part, green tea 0.3-2 part, Radix Notoginseng 0.1-0.8 part.
A kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste the most according to claim 4, it is characterised in that the parts by weight of mixing breaking cellular wall stock solution are by three
Leaf green grass or young crops fresh goods 10 parts, green tea 0.9 part, Radix Notoginseng 0.6 part composition.
7. according to a kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste described in claim 5 to 6, it is characterised in that the preparation of described mixing breaking cellular wall stock solution
Comprise the following steps:
Step one:
The sorting of a, Radix Apioris Fortunei (Radix Lespedezae Buergeri) is cleaned；
B, spectrum sterilizing 5-10 minute；
C, roughing cutting machine shred, and obtain cutting off thing, and are placed under spectrum sterilized environment stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, spectrum sterilizing 5-10 minute；
C, roughing cutting machine shred, and obtain cutting off thing, and are placed under spectrum sterilized environment stand-by；
Step 3:
A, sterilization step one and step 2 obtained cut-out thing and Radix Notoginseng all insert the broken machine of vibration type wall-broken micro powder, this vibration type
The broken machine of wall-broken micro powder is aseptic condition；
B, interpolation ultra-pure water, medicine and water ratio are within 1:1.4；
C, to carry out ultralow constant temperature vibration formula wall-broken micro powder broken, produces mixing breaking cellular wall stock solution, cell under temperature is for-2 DEG C (± 0.1)
Sporoderm-broken rate reaches 98.5%；
D, the spectrum sterilization of mixing breaking cellular wall stock solution elder generation is inserted again cryogenic sterile seal container preserves stand-by, in described sealing container
Storage temperature be-2 DEG C-0 DEG C.
8. the preparation method of a Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste, it is characterised in that the preparation technology of described Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste includes following step
Rapid:
Step one: by the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate in temperature
Being to carry out homogenizing stirring under the constant temperature of 95 DEG C-120 DEG C, mixing time is 10-20 minute, obtains the first stirring thing；
Step 2:
A, the first stirring thing step one obtained are poured into and are stirred in de-airing mixer and cool down, and are cooled to 50 DEG C-75 DEG C；
When b, liter high-temperature are to 60 DEG C-80 DEG C, add the xanthan gum of formula ratio, carrageenan, edible essence；
C, again temperature is increased to 90 DEG C-95 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Pyrusussuriensis
(sugared) alcohol；
D, unlatching vacuum pump, holding pressure is at-0.5MPa～-0.1MPa, and constant temperature high speed is continuously stirred, and mixing speed is every point
Clock 2000-3000 turns, and mixing time is 15-20 minute, obtains the second stirring thing；
Step 3: the second stirring thing step 2 obtained cools down in inserting cream pot processed, and chilling temperature is 60 DEG C-75 DEG C, in temperature
When degree reaches 75 DEG C-85 DEG C, add the mixing breaking cellular wall stock solution of claim 7 preparation of formula ratio, carry out Quick uniform stirring, stir
The time of mixing is 5 minutes, obtains the 3rd stirring thing；
Step 4: lowered the temperature rapidly by the stirring thing of the 3rd stirring thing obtained in step 3, temperature fall time is 59 seconds, temperature decrease
To 25 DEG C-26 DEG C；
Step 5: placing ageing, the temperature of this ageing is 20 DEG C-30 DEG C；
Step 6: Radix Apioris Fortunei (Radix Lespedezae Buergeri) toothpaste is carried out fill.
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| CN201610385214.4A CN105878124A (en) | 2016-06-03 | 2016-06-03 | Radix tetrastigme toothpaste and preparation method thereof |
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| CN114159377A (en) * | 2021-11-01 | 2022-03-11 | 浙江仲兴生物医药科技有限公司 | Radix tetrastigme spray liquid crystal gel for dental ulcer and preparation method thereof |
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