CN109528625A - Oral cavity composition and its application containing probiotics and antibacterial peptide - Google Patents
Oral cavity composition and its application containing probiotics and antibacterial peptide Download PDFInfo
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- CN109528625A CN109528625A CN201910047525.3A CN201910047525A CN109528625A CN 109528625 A CN109528625 A CN 109528625A CN 201910047525 A CN201910047525 A CN 201910047525A CN 109528625 A CN109528625 A CN 109528625A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Gastroenterology & Hepatology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
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- Oral & Maxillofacial Surgery (AREA)
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Abstract
The invention belongs to oral care techniques fields, provide a kind of oral cavity composition containing probiotics and antibacterial peptide, have probiotics and antibacterial peptide in the oral cavity composition.The probiotics and antibacterial peptide that the present invention uses play the role of inhibiting bacteria and diminishing inflammation, can improve oral inflammation problem, have the function of antibacterial anti-inflammatory, alleviating pain and detumescence, and the two combined use can generate synergistic effect, the better effect being used alone than the two.The present invention using probiotics and antibacterial peptide as effective component, with it is presently used have the chemical bactericide of hidden trouble in safety compared with, safety use without side effects, and can be received by products application.
Description
Technical field
The present invention relates to oral care techniques fields, and in particular to a kind of oral cavity composition containing probiotics and antibacterial peptide and
It is applied.
Background technique
Most of oral care implement of bacteriostasis efficacy is laid claim at present using chemical bactericide, such as triclosan, western pyrrole chlorine
Ammonium etc. is used as effective component.But its safety has always secret worry for consumers, such as: triclosan is reacted with the chlorine in tap water
Chloroform is generated, there is carcinogenic danger.The above unfavorable factor hampers consumer using product to mitigate oral inflammation.
Lactobacillus salivarius is a kind of probiotics from oral cavity, has inhibiting effect to the various bacteriums in oral cavity, effect is
There are more document reports.Such as the research opinion in 1) " genomics and applied biology " the 8th phase page 3414 of volume 37 in 2018
Discovery Lactobacillus salivarius can inhibit to deform in literary " inhibiting effect of the Lactobacillus salivarius ZM06 to streptococcus mutans biofilm formation "
The formation of streptococcus organism film.2) research paper " saliva in " dairy industry science and technology " the 3rd phase page 1 of volume 38 in 2015
The growth characteristics and bacteriostasis of lactobacillus " in find its bacterium solution and metabolite to oral cavity streptococcus mutans, porphyromonas list
Born of the same parents bacterium and staphylococcus aureus have bacteriostasis, metabolite of the bacteriostasis mainly from thallus.
Nisin is a kind of natural bioactive antibacterial peptide, be using biotechnology extract one kind it is pure natural,
Efficiently, safe polypeptide active substance.Nisin there is strong inhibition to make many pathogenic gram-positive bacterias
With.And its is highly-safe, is the rhzomorph for being uniquely allowed to be used as food additives in the world at present.Its mechanism of action is to pass through
Destroy bacterium cytoplasma membrane so that bacterium cytoplasm exudation and it is dead.Its antibiotic effect has more document reports.As 1)
Research paper in " the Chinese oral cavity Research of Medical magazine " phase page 425 of volume 9 the 5th of in October, 2015 be " nisin
The progress that characteristic and anti-biotic material are applied in the oral cavity " in mention nisin can inhibit cariogenic bacteria grow and
The formation of its bacterial plaque.2) research paper " the lactic acid chain in " Guangxi Technical College's journal " phase page 63 of volume 12 the 4th of in December, 2001
The research of coccus element fungistatic effect " in discovery nisin have stronger bacteriostasis to 3 kinds of gram-positive bacterias.
Currently, find no Lactobacillus salivarius and nisin while being added to the case in oral care product
Example, and do not find have the function of mutually cooperateing with therebetween yet.
Summary of the invention
For the defects in the prior art, the present invention provides the oral cavity composition containing probiotics and antibacterial peptide and its application,
To improve oral inflammation problem, have the function that alleviating pain and detumescence.
In a first aspect, the oral cavity composition provided by the invention containing probiotics and antibacterial peptide, have in the oral cavity composition
Profitable probliotics and antibacterial peptide.
Optionally, there is 0.01wt%-10wt% probiotics and 0.01wt%-10wt% antibacterial in the oral cavity composition
Peptide.
Optionally, there is 0.1wt%-5wt% probiotics and 5wt%-10wt% antibacterial peptide in the oral cavity composition.
Optionally, there is 5wt%-10wt% probiotics and 0.1wt%-5wt% antibacterial peptide in the oral cavity composition.
Optionally, there is 0.1wt%-5wt% probiotics and 0.1wt%-5wt% antibacterial peptide in the oral cavity composition.
Optionally, there is 1wt% probiotics and 1wt% antibacterial peptide in the oral cavity composition.
It optionally, further include solvent, moisturizer, sweetener, essence, preservative, solubilizer, increasing in the oral cavity composition
It is any a variety of in thick dose, appearance modifying agents, silica, rubbing agent and foaming agent.
Optionally, the probiotics is Lactobacillus salivarius, and the antibacterial peptide is nisin.
Second aspect, oral cavity composition provided by the invention answering in the oral care product that preparation has inhibiting bacteria and diminishing inflammation
With.
Optionally, the oral care product includes toothpaste or tooth powder.
Technical effect of the invention:
1. probiotics and antibacterial peptide that the present invention uses play the role of inhibiting bacteria and diminishing inflammation, oral inflammation problem can be improved, had
Play the role of antibacterial anti-inflammatory, alleviating pain and detumescence, the two combined use can generate synergistic effect, than the two exclusive use effect more
It is good.
2. the present invention, as effective component, is killed using probiotics and antibacterial peptide with the presently used chemistry for having hidden trouble in safety
Microbial inoculum is compared, and safety use without side effects, and can be received by products application.
Specific embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Ground illustrates technical solution of the present invention, therefore is intended only as example, and not intended to limit the protection scope of the present invention.
It should be noted that unless otherwise indicated, technical term or scientific term used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.
Technical solution of the present invention provides a kind of oral cavity composition containing probiotics and antibacterial peptide, the oral cavity composition
In have probiotics and antibacterial peptide.Specifically a bit, the content of probiotics and antibacterial peptide is 0.01wt%-10wt%.
It wherein, further include solvent, moisturizer, sweetener, essence, preservative, solubilizer, thickening in the oral cavity composition
It is any a variety of in agent, appearance modifying agents, silica, rubbing agent and foaming agent.
Solvent is generally water.Water can be contained in toothpaste, and do not need solvent then in tooth powder.
Moisturizer selects sorbierite.Main component of the sorbierite as toothpaste, has hygroscopicity, one effect is to maintain
The moisture of lotion of toothpaste can keep the mobility of lotion and will not harden and block nozzle, keep paste stability, another
A effect is to reduce the freezing point of lotion, so that lotion is not frozen at low temperature and hardens, when lotion is by icy knot, when being heated and melting
The original consistency of lotion each component will be changed and separation is caused to be discharged.
Sweetener selects saccharin sodium.The sugariness of saccharin sodium is 300 times of sucrose solution, and sweetener and essence can make oral cavity
Composition generates a kind of pleasant taste, and masks taste bad caused by other compositions, makes oral cavity composition
With various odor types, toothbrushing person can be made to feel tasty and refreshing comfortable, and help to mitigate halitosis.
Preservative selects methylparaben and propylben.
Solubilizer selects PEG400, and Chinese is polyethylene glycol 400, water-soluble and wider fusing point model with higher
It encloses, moistening effect is obvious, and property is stablized, and compounds with sorbierite, can keep the moisture concentration in toothpaste, improve lotion viscosity stabilization
Property and product stability.
Appearance modifying agents select titanium dioxide.It is primarily used to increase the whiteness and covering of lotion using titanium dioxide in toothpaste
Power.
Silica, which is used in toothpaste, has good thixotropy and wear resistance.Because its good thixotropy can be effective
It solves the problems, such as that the toothpaste brushed teeth is scaling-off, simultaneously as its wear resistance coefficient is matched with tooth, reduces the wear intensity to tooth,
And chemical property is stablized.
Rubbing agent selects calcium monohydrogen phosphate.Rubbing agent is used in tooth powder, can wipe dental surface tooth with toothbrush collective effect
Dirt mitigates the foreign substances such as tooth stain, plaque, calculus dentalis.
Foaming agent selects K12.K12 belongs to anionic surfactant, soluble easily in water, compounds 5 with anion, nonionic
Property it is good, there is good emulsification, foaming, infiltration, decontamination and dispersion performance, foaming abundancy.
First embodiment of the invention provides the application that the oral cavity composition has the toothpaste of antibacterial anti-inflammatory in preparation,
Its concrete component formula is shown in Table 1.
Table 1
The preparation process of toothpaste is as follows:
S1, PEG-400, sorbierite and saccharin sodium are dissolved with water, forms solution；
S2, Lactobacillus salivarius, nisin, titanium dioxide, thickener, silica and K12 are uniformly mixed, are added
Solution in S1, stirs evenly in a vacuum, forms lotion；
S3, methylparaben and propylben are dissolved with essence, and are added in the lotion of S2, stirred evenly in vacuum,
Toothpaste preparation is completed.
Second embodiment of the invention provides the application that the oral cavity composition has the tooth powder of antibacterial anti-inflammatory in preparation,
Its concrete component formula is shown in Table 2.
Table 2
| Component | Mass content |
| Lactobacillus salivarius | 0.01wt%-10wt% |
| Nisin | 0.01wt%-10wt% |
| Saccharin sodium | 0.01wt%-0.5wt% |
| Essence | 0.05wt%-2wt% |
| Methylparaben | 0.05wt%-0.5wt% |
| Propylben | 0.05wt%-0.5wt% |
| Calcium monohydrogen phosphate | Surplus |
| It is total | 100% |
The preparation process of tooth powder is as follows:
S1, Lactobacillus salivarius, nisin, saccharin sodium, calcium monohydrogen phosphate are uniformly mixed, form powder；
S2, methylparaben and propylben are dissolved with essence, forms fragrance solution, and the spraying spray of fragrance solution
It in the powder of S1, stirs evenly, tooth powder preparation is completed.
The present invention also provides following multiple specific embodiments, concrete component is shown in Table 3.
Table 3
In order to verify oral care product of the invention antibacterial anti-inflammatory effect, referring to " 2738 daily chemical products of QB/T are anti-
Bacterium fungistatic effect evaluation method " carry out following test.Wherein,
Composition A contains 1wt% Lactobacillus salivarius,
Composition B contains 0.5wt% nisin,
Composition C contains 0.5wt% Lactobacillus salivarius and 0.5wt% nisin.
Test 1
Using etc. the composition A, composition B and composition C of quality sterilization test is carried out to Escherichia coli respectively, when test
Between be 5min, test result is shown in Table 4.
Table 4
| Originate clump count | Recycle clump count | Sterilizing rate | |
| Composition A | 1.85x108 | 5.7x107 | 69.19% |
| Composition B | 2.01x108 | 4.1x107 | 79.6% |
| Composition C | 1.93x108 | 9.5x106 | 95.07% |
Test 2
Using etc. quality composition A, composition B and composition C respectively to staphylococcus aureus carry out sterilization test,
Test period is 5min, and test result is shown in Table 5.
Table 5
| Originate clump count | Recycle clump count | Sterilizing rate | |
| Composition A | 1.89x108 | 3.90x107 | 79.36% |
| Composition B | 2.34x108 | 7.49x107 | 67.99% |
| Composition C | 3.10x108 | 2.84x106 | 99.08% |
Test 3
Using etc. quality composition A, composition B and composition C respectively to Candida albicans carry out sterilization test, test
Time is 5min, and test result is shown in Table 6.
Table 6
| Originate clump count | Recycle clump count | Sterilizing rate | |
| Composition A | 1.55x108 | 5.4x107 | 65.16% |
| Composition B | 2.11x108 | 4.25x107 | 79.86% |
| Composition C | 2.51x108 | 5.12x106 | 97.96% |
By table 4- table 6 the results show that the oral cavity composition C simultaneously containing Lactobacillus salivarius and nisin to three
The killing effect of kind pathogenic bacteria will be apparently higher than the individually composition A containing Lactobacillus salivarius and individually contain streptococcus lactis
The composition B of element.The present invention will carry out quick anti-inflammatory to the killing of oral cavity pathogen by using the oral cavity composition, prevent inflammation
The generation of infection.
Unless specifically stated otherwise, the numerical value otherwise illustrated in these embodiments is not limit the scope of the invention.?
In all examples shown and described herein, unless otherwise prescribed, any occurrence should be construed as merely illustratively, and
Not by way of limitation, therefore, other examples of exemplary embodiment can have different values.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme should all cover within the scope of the claims and the description of the invention.
Claims (10)
1. the oral cavity composition containing probiotics and antibacterial peptide, which is characterized in that there is probiotics in the oral cavity composition and resist
Bacterium peptide.
2. the oral cavity composition according to claim 1 containing probiotics and antibacterial peptide, which is characterized in that the oral compositions
There is 0.01wt%-10wt% probiotics and 0.01wt%-10wt% antibacterial peptide in object.
3. the oral cavity composition according to claim 2 containing probiotics and antibacterial peptide, which is characterized in that the oral compositions
There is 0.1wt%-5wt% probiotics and 5wt%-10wt% antibacterial peptide in object.
4. the oral cavity composition according to claim 2 containing probiotics and antibacterial peptide, which is characterized in that the oral compositions
There is 5wt%-10wt% probiotics and 0.1wt%-5wt% antibacterial peptide in object.
5. the oral cavity composition according to claim 2 containing probiotics and antibacterial peptide, which is characterized in that the oral compositions
There is 0.1wt%-5wt% probiotics and 0.1wt%-5wt% antibacterial peptide in object.
6. the oral cavity composition according to claim 5 containing probiotics and antibacterial peptide, which is characterized in that the oral compositions
There is 1wt% probiotics and 1wt% antibacterial peptide in object.
7. the oral cavity composition according to claim 1 containing probiotics and antibacterial peptide, which is characterized in that the oral compositions
Further include solvent in object, moisturizer, sweetener, essence, preservative, solubilizer, thickener, appearance modifying agents, silica, rub
It is any a variety of in liniment and foaming agent.
8. the oral cavity composition described in any one of -7 containing probiotics and antibacterial peptide according to claim 1, which is characterized in that institute
Stating probiotics is Lactobacillus salivarius, and the antibacterial peptide is nisin.
9. any oral cavity composition the answering in the oral care product that preparation has inhibiting bacteria and diminishing inflammation of claim 1-8
With.
10. application according to claim 9, which is characterized in that the oral care product includes toothpaste or tooth powder.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910047525.3A CN109528625A (en) | 2019-01-18 | 2019-01-18 | Oral cavity composition and its application containing probiotics and antibacterial peptide |
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| CN201910047525.3A CN109528625A (en) | 2019-01-18 | 2019-01-18 | Oral cavity composition and its application containing probiotics and antibacterial peptide |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113679632B (en) * | 2021-09-01 | 2022-09-27 | 好易康生物科技(广州)有限公司 | Application of antibacterial peptide compound DM80Bu20 in preparation of antibacterial toothpaste |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265470A (en) * | 2016-08-12 | 2017-01-04 | 宝鸡市星星协力生物有限公司 | Probiotics fermention compound recipe herbaceous toothpaste |
-
2019
- 2019-01-18 CN CN201910047525.3A patent/CN109528625A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265470A (en) * | 2016-08-12 | 2017-01-04 | 宝鸡市星星协力生物有限公司 | Probiotics fermention compound recipe herbaceous toothpaste |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国国家质量监督检验检疫总局: "《牙膏用原料规范》", 27 June 2008 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113679632B (en) * | 2021-09-01 | 2022-09-27 | 好易康生物科技(广州)有限公司 | Application of antibacterial peptide compound DM80Bu20 in preparation of antibacterial toothpaste |
| WO2023029137A1 (en) * | 2021-09-01 | 2023-03-09 | 好易康生物科技(广州)有限公司 | Application of antibacterial peptide compound dm80bu20 in preparation of antibacterial toothpaste |
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