CN109512740A - Oral cavity composition and its application containing licorice and Cortex Ilicis Rotundae extract - Google Patents
Oral cavity composition and its application containing licorice and Cortex Ilicis Rotundae extract Download PDFInfo
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- CN109512740A CN109512740A CN201811563448.9A CN201811563448A CN109512740A CN 109512740 A CN109512740 A CN 109512740A CN 201811563448 A CN201811563448 A CN 201811563448A CN 109512740 A CN109512740 A CN 109512740A
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- oral cavity
- licorice
- cortex ilicis
- ilicis rotundae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Life Sciences & Earth Sciences (AREA)
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- Organic Chemistry (AREA)
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- Oral & Maxillofacial Surgery (AREA)
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- Cosmetics (AREA)
Abstract
The invention belongs to oral care techniques field, a kind of oral cavity composition containing licorice and Cortex Ilicis Rotundae extract and its application are provided, there is licorice and Cortex Ilicis Rotundae extract in the oral cavity composition.The licorice and Cortex Ilicis Rotundae extract that the present invention uses play the role of inhibiting bacteria and diminishing inflammation, can improve oral inflammation problem, have the function of that analgesia detumescence, the two combined use can generate synergistic effect, the better effect being used alone than the two.
Description
Technical field
The present invention relates to oral care techniques fields, and in particular to a kind of mouth containing licorice and Cortex Ilicis Rotundae extract
Chamber composition and its application.
Background technique
For licorice containing anti-inflammation components such as glycyrrhizic acid and enoxolones, effects of antiinflammation and bacteriostasis has many places document note
It carries.Such as: 1) in " oral care implement industry " volume 27 the 5th page 18 paper " anti-inflammatory effect of dipotassium glycyrrhizinate study and its
Application in toothpaste " middle mouse ear swelling the experimental results showed that, the toothpaste containing dipotassium glycyrrhizinate has internal anti-inflammatory effect.
2) in the paper " experimental study of glycyrrhetate antibacterial action " in " Chengde Medical College's journal " V28, No.3,2011, research hair
Existing, disodium glycyrrhizinate, dipotassium glycyrrhizinate, diammonium glycyrrhizinate are in vitro under experiment condition, to staphylococcus aureus, white grapes
The bacteriums such as coccus, escherichia coli, shigella flexneri, moscow' paratyphi B are demonstrated by different degrees of antibacterial
Effect.
Iron holly bark also known as white Pi Dongqing, effects of antiinflammation and bacteriostasis have many places document and record.Such as: 1) Jiangxi " herbal medicine hand
Volume ": " clearing heat and promoting diuresis, swelling and pain relieving.Cure cold fever, tonsillitis, abscess of throat, acute gastroenteritis, and stomach and duodenum are burst
Ulcer, traumatic injury, rheumatism." what 2) " oral care implement industry " volume 25 the 1st was delivered for 2 months 2015 " has anti-gum
The natural extract of scorching effect is studied and its clinical application in toothpaste " in the study found that the medium-height grass of Cortex Ilicis Rotundae extract
Medicine toothpaste has the formation for inhibiting plaque compared with using control group toothpaste, reduces index of gingivitis, mitigates becoming for gingivitis
Gesture has the function of improving gums healthy.
Lay claim to used by the oral-cavity article of antimicrobial and anti-inflammation efficacy at present it is most of for chemical bactericide, as triclosan,
Cetylpyridinium Chloride etc. is used as its effective component, but its safety has always secret worry for consumers: as it is reported that triclosan with from
Chlorine reaction in water generates chloroform, there is carcinogenic hidden danger.The above unfavorable factor hampers consumer using product to mitigate mouth
Chamber inflammation.
Currently, find no licorice and Cortex Ilicis Rotundae extract while being added to the case in oral care product
Example, and do not find have the function of mutually cooperateing with therebetween yet.
Summary of the invention
For the defects in the prior art, the present invention provides a kind of oral cavity group containing licorice and Cortex Ilicis Rotundae extract
Object and its application are closed, to improve oral inflammation problem, has the function that analgesia detumescence.
In a first aspect, the oral cavity composition provided by the invention containing licorice and Cortex Ilicis Rotundae extract, the oral cavity
There is licorice and Cortex Ilicis Rotundae extract in composition.
Optionally, in the oral cavity composition there is 0.1wt%-10wt% licorice and 0.1wt%-10wt% to rescue
Extract must be answered.
Optionally, there is 1wt%-5wt% licorice and 5wt%-10wt% iron holly bark in the oral cavity composition
Extract.
Optionally, there is 5wt%-10wt% licorice and 1wt%-5wt% iron holly bark in the oral cavity composition
Extract.
Optionally, in the oral cavity composition there is 1wt%-5wt% licorice and 1wt%-5wt% iron holly bark to mention
Take object.
Optionally, there is 3wt% licorice and 3wt% Cortex Ilicis Rotundae extract in the oral cavity composition.
It optionally, further include solvent, moisturizer, sweetener, fluoride, essence, preservative, increasing in the oral cavity composition
It is any a variety of in solvent, thickener, appearance modifying agents, silica, rubbing agent, foaming agent and emulsifier.
Optionally, the Cortex Ilicis Rotundae extract and the licorice are water extract.
Second aspect, the present invention provides the oral cavity compositions to have the oral care product of antibacterial anti-inflammatory in preparation
In application.
Optionally, the oral care product includes toothpaste, tooth powder, mouthwash or flavorants.
Technical effect of the invention:
1. licorice and Cortex Ilicis Rotundae extract that the present invention uses play the role of inhibiting bacteria and diminishing inflammation, stomatitis can be improved
Disease problem, have the function of analgesia detumescence, the two combined use can generate synergistic effect, than the two exclusive use effect more
It is good.
2. licorice and Cortex Ilicis Rotundae extract that the present invention uses are killed with the presently used chemistry for having hidden trouble in safety
Microbial inoculum is compared, safety use without side effects and, can be received by products application.
Specific embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Ground illustrates technical solution of the present invention, therefore is intended only as example, and not intended to limit the protection scope of the present invention.
It should be noted that unless otherwise indicated, technical term or scientific term used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.
Technical solution of the present invention provides a kind of oral cavity composition containing licorice and Cortex Ilicis Rotundae extract, described
There is licorice and Cortex Ilicis Rotundae extract in oral cavity composition.Specifically a bit, licorice and Cortex Ilicis Rotundae extract
Content is 0.1wt%-10wt%.
The Cortex Ilicis Rotundae extract and the licorice are water extract.
It wherein, further include solvent, moisturizer, sweetener, fluoride, essence, preservative, solubilising in the oral cavity composition
It is any a variety of in agent, thickener, appearance modifying agents, silica, rubbing agent, foaming agent and emulsifier.
Solvent is generally water.In toothpaste, water can be all contained in mouthwash and flavorants.
Moisturizer selects sorbierite.Main component of the sorbierite as toothpaste, has hygroscopicity, one effect is to maintain
The moisture of lotion of toothpaste can keep the mobility of lotion and will not harden and block nozzle, keep paste stability, another
A effect is to reduce the freezing point of lotion, so that lotion is not frozen at low temperature and hardens, when lotion is by icy knot, when being heated and melting
The original consistency of lotion each component will be changed and separation is caused to be discharged.
Sweetener selects saccharin sodium.The sugariness of saccharin sodium is 300 times of sucrose solution, and sweetener and essence can make oral cavity
Composition generates a kind of pleasant taste, and masks taste bad caused by other compositions, makes oral cavity composition
With various odor types, toothbrushing person can be made to feel tasty and refreshing comfortable, and help to mitigate halitosis.
Fluoride selects sodium fluoride.Fluoride can effectively pre- anti-caries, being inserted in oral cavity composition can pre- anti-caries.Just
It is often used safe and harmless.
Preservative selects methylparaben and propylben.
Solubilizer selects PEG400, and Chinese is polyethylene glycol 400, water-soluble and wider fusing point model with higher
It encloses, moistening effect is obvious, and property is stablized, and compounds with sorbierite, can keep the moisture concentration in toothpaste, improve lotion viscosity stabilization
Property and product stability.
Appearance modifying agents select titanium dioxide.In oral cavity composition using titanium dioxide be primarily used to increase lotion whiteness and
Covering power.
Silica, which is used in toothpaste, has good thixotropy and wear resistance.Because its good thixotropy can be effective
It solves the problems, such as that the toothpaste brushed teeth is scaling-off, simultaneously as its wear resistance coefficient is matched with tooth, reduces the wear intensity to tooth,
And chemical property is stablized.
Rubbing agent selects calcium monohydrogen phosphate.Rubbing agent can wipe dental surface tartar with toothbrush collective effect, mitigate tooth
The foreign substances such as stain, plaque, calculus dentalis.
Foaming agent selects K12.K12 belongs to anionic surfactant, soluble easily in water, compounds 5 with anion, nonionic
Property it is good, there is good emulsification, foaming, infiltration, decontamination and dispersion performance, foaming abundancy.
Emulsifier selects Tween-20.Tween-20 belongs to nonionic surfactant, soluble easily in water, methanol, ethyl alcohol, isopropyl
The multi-solvents such as alcohol have the performances such as emulsification, diffusion, increase-volume, stabilization insoluble in dynamic, mineral oil.
First embodiment of the invention provides the application that the oral cavity composition has the toothpaste of antibacterial anti-inflammatory in preparation,
Its concrete component formula is shown in Table 1.
Table 1
The preparation process of toothpaste is as follows:
S1, PEG-400, sorbierite, saccharin sodium and sodium fluoride are dissolved with water, forms solution；
S2, licorice, Cortex Ilicis Rotundae extract, titanium dioxide, thickener, silica and K12 are uniformly mixed, are added
Solution in S1, stirs evenly in a vacuum, forms lotion；
S3, methylparaben and propylben are dissolved with essence, and are added in the lotion of S2, stirred evenly in vacuum,
Toothpaste preparation is completed.
Second embodiment of the invention, which provides the oral cavity composition, has answering for the mouthwash of antibacterial anti-inflammatory in preparation
With concrete component formula is shown in Table 2.
Table 2
The preparation process of mouthwash is as follows:
S1, licorice, Cortex Ilicis Rotundae extract, sorbierite, sodium fluoride, saccharin sodium are dissolved with water, forms solution；
S2, Tween-20, methylparaben and propylben are dissolved with essence, and is stirred evenly with the solution of S1, gargled
Water preparation is completed.
Third embodiment of the invention provides the application that the oral cavity composition has the tooth powder of antibacterial anti-inflammatory in preparation,
Its concrete component formula is shown in Table 3.
Table 3
The preparation process of tooth powder is as follows:
S1, licorice, Cortex Ilicis Rotundae extract, sodium fluoride, saccharin sodium, calcium monohydrogen phosphate are uniformly mixed, form powder；
S2, methylparaben and propylben are dissolved with essence, forms fragrance solution, and the spraying spray of fragrance solution
It in the powder of S1, stirs evenly, tooth powder preparation is completed.
Fourth embodiment of the invention provides the flavorants that the oral cavity composition has antibacterial anti-inflammatory in preparation
Application, concrete component formula is shown in Table 4.
Table 4
| Component | Mass content |
| Licorice | 0.1wt%-10wt% |
| Cortex Ilicis Rotundae extract | 0.1wt%-10wt% |
| Sorbierite | 0.1wt%-50wt% |
| Saccharin sodium | 0.01wt%-0.5wt% |
| Sodium fluoride | 0.05wt%-0.5wt% |
| Essence | 0.05wt%-2wt% |
| Methylparaben | 0.05wt%-0.5wt% |
| Propylben | 0.05wt%-0.5wt% |
| Water | Surplus |
| It is total | 100% |
The preparation process of flavorants is as follows:
S1, licorice, Cortex Ilicis Rotundae extract, sorbierite, sodium fluoride, saccharin sodium are dissolved with water, forms solution；
S2, methylparaben and propylben are dissolved with essence, forms fragrance solution, and the molten of fragrance solution and S1
Liquid stirs evenly, and flavorants preparation is completed.
The present invention also provides following multiple specific embodiments, concrete component is shown in Table 5.
Table 5
In order to verify oral care product of the invention antibacterial anti-inflammatory effect, referring to " 2738 daily chemical products of QB/T are anti-
Bacterium fungistatic effect evaluation method " carry out following test.Wherein,
Composition A contains 1wt% licorice,
Composition B contains 0.5wt% Cortex Ilicis Rotundae extract,
Composition C contains 0.5wt% licorice and 0.5wt% Cortex Ilicis Rotundae extract.
Test 1
Using etc. the composition A, composition B and composition C of quality sterilization test is carried out to Escherichia coli respectively, when test
Between be 5min, test result is shown in Table 6.
Table 6
| Originate clump count | Recycle clump count | Sterilizing rate | |
| Composition A | 2.38x108 | 4.8x107 | 79.83% |
| Composition B | 2.30x108 | 4.5x107 | 80.43% |
| Composition C | 2.25x108 | 6.8x105 | 99.70% |
Test 2
Using etc. quality composition A, composition B and composition C respectively to staphylococcus aureus carry out sterilization test,
Test period is 5min, and test result is shown in Table 7.
Table 7
| Originate clump count | Recycle clump count | Sterilizing rate | |
| Composition A | 1.3x108 | 3.8x107 | 70.77% |
| Composition B | 3.0x108 | 4.9x107 | 83.67% |
| Composition C | 2.5x108 | 1.8x106 | 99.28% |
Test 3
Using etc. quality composition A, composition B and composition C respectively to Candida albicans carry out sterilization test, test
Time is 5min, and test result is shown in Table 8.
Table 8
| Originate clump count | Recycle clump count | Sterilizing rate | |
| Composition A | 1.6x108 | 3.3x107 | 79.38% |
| Composition B | 1.6x108 | 2.76x107 | 82.75% |
| Composition C | 1.35x108 | 4.6x105 | 99.65% |
By table 6- table 8 the results show that the oral cavity composition C simultaneously containing licorice and Cortex Ilicis Rotundae extract to three
The killing effect of kind pathogenic bacteria will be apparently higher than the individually composition A containing licorice and individually extract containing iron holly bark
The composition B of object.
The present invention will carry out quick anti-inflammatory to the killing of oral cavity pathogen by using the oral cavity composition, prevent inflammation infection
Generation.
Unless specifically stated otherwise, the numerical value otherwise illustrated in these embodiments is not limit the scope of the invention.?
In all examples shown and described herein, unless otherwise prescribed, any occurrence should be construed as merely illustratively, and
Not by way of limitation, therefore, other examples of exemplary embodiment can have different values.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme should all cover within the scope of the claims and the description of the invention.
Claims (10)
1. a kind of oral cavity composition containing licorice and Cortex Ilicis Rotundae extract, which is characterized in that in the oral cavity composition
With licorice and Cortex Ilicis Rotundae extract.
2. the oral cavity composition according to claim 1 containing licorice and Cortex Ilicis Rotundae extract, which is characterized in that institute
Stating has 0.1wt%-10wt% licorice and 0.1wt%-10wt% Cortex Ilicis Rotundae extract in oral cavity composition.
3. the oral cavity composition according to claim 2 containing licorice and Cortex Ilicis Rotundae extract, which is characterized in that institute
Stating has 1wt%-5wt% licorice and 5wt%-10wt% Cortex Ilicis Rotundae extract in oral cavity composition.
4. the oral cavity composition according to claim 2 containing licorice and Cortex Ilicis Rotundae extract, which is characterized in that institute
Stating has 5wt%-10wt% licorice and 1wt%-5wt% Cortex Ilicis Rotundae extract in oral cavity composition.
5. the oral cavity composition according to claim 2 containing licorice and Cortex Ilicis Rotundae extract, which is characterized in that institute
Stating has 1wt%-5wt% licorice and 1wt%-5wt% Cortex Ilicis Rotundae extract in oral cavity composition.
6. the oral cavity composition according to claim 5 containing licorice and Cortex Ilicis Rotundae extract, which is characterized in that institute
Stating has 3wt% licorice and 3wt% Cortex Ilicis Rotundae extract in oral cavity composition.
7. the oral cavity composition according to claim 1 containing licorice and Cortex Ilicis Rotundae extract, which is characterized in that institute
State further includes solvent, moisturizer, sweetener, fluoride, essence, preservative, solubilizer, thickener, appearance in oral cavity composition
It is any a variety of in modifying agent, silica, rubbing agent, foaming agent and emulsifier.
8. the oral cavity composition according to claim 1 containing licorice and Cortex Ilicis Rotundae extract, which is characterized in that institute
Stating Cortex Ilicis Rotundae extract and the licorice is water extract.
9. any oral cavity composition the answering in the oral care product that preparation has antibacterial anti-inflammatory of claim 1-8
With.
10. application according to claim 9, which is characterized in that the oral care product includes toothpaste, tooth powder, gargles
Water or flavorants.
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| CN201811563448.9A CN109512740B (en) | 2018-12-20 | 2018-12-20 | Oral composition containing licorice extract and ovateleaf holly bark extract and application thereof |
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| CN201811563448.9A CN109512740B (en) | 2018-12-20 | 2018-12-20 | Oral composition containing licorice extract and ovateleaf holly bark extract and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638910A (en) * | 2019-08-26 | 2020-01-03 | 白银香生物科技有限公司 | A breath freshener with antiviral, antibacterial and antiinflammatory effects, and its preparation method |
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2018
- 2018-12-20 CN CN201811563448.9A patent/CN109512740B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107582796A (en) * | 2017-09-21 | 2018-01-16 | 安徽亚泰药业有限公司 | A kind of pure and fresh cough relief traditional Chinese medicine lozenge of diminishing inflammation and clearing pharynx and preparation method thereof |
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| CN110638910A (en) * | 2019-08-26 | 2020-01-03 | 白银香生物科技有限公司 | A breath freshener with antiviral, antibacterial and antiinflammatory effects, and its preparation method |
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