CN109512740B - Oral composition containing licorice extract and ovateleaf holly bark extract and application thereof - Google Patents
Oral composition containing licorice extract and ovateleaf holly bark extract and application thereof Download PDFInfo
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- CN109512740B CN109512740B CN201811563448.9A CN201811563448A CN109512740B CN 109512740 B CN109512740 B CN 109512740B CN 201811563448 A CN201811563448 A CN 201811563448A CN 109512740 B CN109512740 B CN 109512740B
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- 239000000203 mixture Substances 0.000 title claims abstract description 46
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- 235000002294 Ilex volkensiana Nutrition 0.000 title claims abstract description 31
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- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 16
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 14
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 14
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 12
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- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 9
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- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 6
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- 230000004054 inflammatory process Effects 0.000 abstract description 7
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229920001213 Polysorbate 20 Polymers 0.000 description 3
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
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- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
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- 241000222122 Candida albicans Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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- 206010044029 Tooth deposit Diseases 0.000 description 1
- KPQJOKRSYYJJEL-VLQRKCJKSA-K [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O Chemical compound [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O KPQJOKRSYYJJEL-VLQRKCJKSA-K 0.000 description 1
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- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical group [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
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- SPPIIOPGDLITJE-VLQRKCJKSA-N diazanium;(2s,3s,4s,5r,6s)-6-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-5-[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihy Chemical compound N.N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O SPPIIOPGDLITJE-VLQRKCJKSA-N 0.000 description 1
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- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001965 increasing effect Effects 0.000 description 1
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- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
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- 230000008018 melting Effects 0.000 description 1
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- 210000000214 mouth Anatomy 0.000 description 1
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- 230000000149 penetrating effect Effects 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical group OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of oral care, and provides an oral composition containing a liquorice extract and an ovateleaf holly bark extract and application thereof. The liquorice extract and the ovateleaf holly bark extract adopted by the invention have the functions of inhibiting bacteria and diminishing inflammation, can improve the problem of oral inflammation, have the functions of relieving pain and diminishing swelling, can generate a synergistic effect when being used in combination, and have better effect than the effect when being used independently.
Description
Technical Field
The invention relates to the technical field of oral care, in particular to an oral composition containing a liquorice extract and an ovateleaf holly bark extract and application thereof.
Background
The licorice extract contains glycyrrhizic acid, glycyrrhetinic acid and other anti-inflammatory components, and has anti-inflammatory and bacteriostatic effects which are recorded in various documents. Such as: 1) the results of experiments on the swelling of the ears of mice in a paper on page 18 of the research on the anti-inflammatory action of dipotassium glycyrrhizinate and its use in toothpaste, Vol.27, volume 5, of the industry of oral care products, show that the toothpaste containing dipotassium glycyrrhizinate has an in vivo anti-inflammatory action. 2) In the experimental study on the antibacterial effect of glycyrrhetate, which is a paper in the proceedings of the Chengde medical college V28 and No.3,2011, the research finds that the disodium glycyrrhizinate, the dipotassium glycyrrhizinate and the diammonium glycyrrhizinate have different degrees of antibacterial effects on staphylococcus aureus, staphylococcus albus, escherichia coli, shigella flexneri, salmonella paratyphi B and other bacteria under in-vitro experimental conditions.
The ovateleaf holly bark, also called white-skin holly root, has been documented in many places for its anti-inflammatory and bacteriostatic effects. Such as: 1) jiangxi 'herbal handbook': clearing heat and promoting diuresis, and relieving swelling and pain. It is used to treat common cold, fever, tonsillitis, sore throat, acute gastroenteritis, gastric and duodenal ulcer, traumatic injury, and rheumatism. "2)" oral Care articles industry "volume 25, book 1, 2015 2 published" research on natural extract with anti-gingivitis effect and clinical application in toothpaste "found that the Chinese herbal toothpaste of ovate leaf holly bark extract has the effects of inhibiting formation of dental plaque, reducing gingivitis index, alleviating tendency of gingivitis and improving gum health compared with the use of control group toothpaste.
Most of oral products declared to have antibacterial and anti-inflammatory effects at present adopt chemical bactericides, such as triclosan, cetylpyridinium chloride and the like as effective components, but the safety of the oral products is always worried by consumers: triclosan is reported to react with chlorine in tap water to produce chloroform, which is a carcinogenic hazard. The above disadvantages prevent consumers from using the product to reduce oral inflammation.
At present, no case that the liquorice extract and the ovateleaf holly bark extract are simultaneously added into the oral care product is found, and no synergistic effect between the liquorice extract and the ovateleaf holly bark extract is found.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides an oral composition containing a liquorice extract and a holly bark extract and application thereof, so as to solve the problem of oral inflammation and achieve the effects of relieving pain and diminishing swelling.
In a first aspect, the present invention provides an oral composition comprising a licorice extract and an ovate leaf holly bark extract, wherein the oral composition comprises the licorice extract and the ovate leaf holly bark extract.
Optionally, the oral composition has 0.1wt% to 10wt% licorice extract and 0.1wt% to 10wt% ovate leaf holly bark extract.
Optionally, the oral composition has 1wt% to 5wt% licorice extract and 5wt% to 10wt% ovate leaf holly bark extract.
Optionally, the oral composition has 5wt% to 10wt% licorice extract and 1wt% to 5wt% ovate leaf holly bark extract.
Optionally, the oral composition has 1wt% to 5wt% licorice extract and 1wt% to 5wt% ovate leaf holly bark extract.
Optionally, the oral composition has 3wt% licorice extract and 3wt% ovate leaf holly bark extract.
Optionally, any of a solvent, humectant, sweetener, fluoride, essence, preservative, solubilizer, thickener, appearance modifier, silica, abrasive, foaming agent, and emulsifier is also included in the oral composition.
Optionally, the ilex rotundifolia extract and the licorice extract are both water extracts.
In a second aspect, the invention provides the use of the oral composition in the manufacture of an oral care product having antibacterial and anti-inflammatory properties.
Optionally, the oral care product comprises a toothpaste, a dentifrice, a mouthwash, or a breath freshener.
The invention has the technical effects that:
1. the liquorice extract and the ovateleaf holly bark extract adopted by the invention have the functions of inhibiting bacteria and diminishing inflammation, can improve the problem of oral inflammation, have the functions of relieving pain and diminishing swelling, can generate a synergistic effect when being used in combination, and have better effect than the effect when being used independently.
2. Compared with the currently used chemical bactericide with safety concern, the liquorice extract and the ovateleaf holly bark extract adopted by the invention are safe to use, have no side effect and can be accepted by product application.
Detailed Description
Hereinafter, embodiments of the present invention will be described in detail. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.
The technical scheme of the invention provides an oral composition containing a liquorice extract and an ovateleaf holly bark extract, wherein the oral composition contains the liquorice extract and the ovateleaf holly bark extract. Specifically, the content of the licorice extract and the holly bark extract is 0.1wt% -10 wt%.
The ilex rotundifolia thumb extract and the liquorice extract are water extracts.
Wherein the oral composition further comprises any of a solvent, a humectant, a sweetener, fluoride, an essence, a preservative, a solubilizer, a thickener, an appearance modifier, silicon dioxide, an abrasive, a foaming agent and an emulsifier.
The solvent is typically water. Water is contained in toothpastes, mouthwashes and breath fresheners.
The humectant is sorbitol. Sorbitol is used as the main component of the toothpaste and has hygroscopicity, one function of the sorbitol is to keep the moisture of the toothpaste body of the toothpaste, so that the toothpaste body can keep the fluidity of the toothpaste body without hardening to block a pipe orifice and keep the stability of the toothpaste body, the other function of the sorbitol is to reduce the freezing point of the toothpaste body, so that the toothpaste body cannot be frozen and hardened at low temperature, and when the toothpaste body is frozen and melted by heating, the original consistency of each component of the toothpaste body is changed and water is separated.
The sweetener is saccharin sodium. The sweetness of the saccharin sodium salt is 300 times that of the sucrose solution, and the sweetener and flavor can impart a pleasant taste to the oral composition and mask the unpleasant taste of other ingredients, impart various flavors to the oral composition, provide a refreshing feeling and comfort to the toothbrushing person, and help alleviate halitosis.
The fluoride is sodium fluoride. Fluoride is effective in preventing dental caries and can be added to oral compositions to prevent dental caries. Is safe and harmless in normal use.
The antiseptic is methyl hydroxybenzoate and propyl hydroxybenzoate.
The solubilizer is PEG400, the Chinese name is polyethylene glycol 400, the water solubility and the melting point range are high, the moisturizing effect is obvious, the property is stable, and the water concentration in the toothpaste can be kept, the viscosity stability of the paste is improved, and the product stability can be improved by compounding the solubilizer with sorbitol.
The appearance modifier is titanium dioxide. Titanium dioxide is used in oral compositions primarily to increase the whiteness and hiding power of the paste.
The silica has good thixotropy and abrasive resistance when used in toothpaste. The toothpaste can effectively solve the problem of toothpaste slag falling during tooth brushing due to good thixotropy, and meanwhile, the abrasion degree of the toothpaste on teeth is reduced due to the fact that the coefficient of the abrasion resistance of the toothpaste is matched with the teeth, and the toothpaste is stable in chemical property.
The friction agent is calcium hydrogen phosphate. The abrasive can be used together with toothbrush to wipe off tartar on teeth surface and relieve dental stain, dental plaque, dental calculus, etc.
The foaming agent is K12. K12 belongs to anionic surfactant, is easily soluble in water, has good compatibility with anions and non-ions, has good emulsifying, foaming, penetrating, decontaminating and dispersing performances, and has abundant foam.
Tween-20 is selected as emulsifier. Tween-20 belongs to nonionic surfactant, is easily soluble in various solvents such as water, methanol, ethanol, isopropanol, etc., is insoluble in animal and mineral oil, and has emulsifying, diffusing, capacity-increasing, and stabilizing properties.
The first embodiment of the invention provides the application of the oral composition in preparing toothpaste with antibacterial and anti-inflammatory effects, and the specific component formula is shown in table 1.
TABLE 1
The preparation process of the toothpaste comprises the following steps:
s1, dissolving PEG-400, sorbitol, saccharin sodium and sodium fluoride in water to form a solution;
s2, uniformly mixing the licorice extract, the ovate leaf holly bark extract, titanium dioxide, a thickening agent, silicon dioxide and K12, adding the solution in S1, and uniformly stirring in vacuum to form paste;
s3, dissolving methyl paraben and propyl paraben in essence, adding into the paste of S2, and stirring uniformly in vacuum to complete the preparation of the toothpaste.
The second embodiment of the present invention provides the use of the oral composition in the preparation of a mouthwash having antibacterial and anti-inflammatory properties, and the specific formulation thereof is shown in table 2.
TABLE 2
The preparation process of the mouthwash is as follows:
s1, dissolving radix Glycyrrhizae extract, cortex Ilicis Rotundae extract, sorbitol, sodium fluoride, and saccharin sodium in water to obtain solution;
s2, dissolving Tween-20, methyl paraben and propyl paraben in essence, and uniformly stirring with the solution of S1 to obtain the mouthwash.
In a third embodiment of the present invention, the use of the oral composition for preparing a breath freshener with antibacterial and anti-inflammatory effects is provided, and the specific component formulation is shown in table 3.
TABLE 3
The preparation process of the breath freshener comprises the following steps:
s1, dissolving radix Glycyrrhizae extract, cortex Ilicis Rotundae extract, sorbitol, sodium fluoride, and saccharin sodium in water to obtain solution;
s2, dissolving methyl paraben and propyl paraben with essence to form essence solution, and uniformly stirring the essence solution and the solution S1 to obtain the breath freshener.
In order to verify the antibacterial and anti-inflammatory effects of the oral care product of the present invention, the following test was conducted with reference to "method for evaluating antibacterial and bacteriostatic effects of QB/T2738 daily chemical products". Wherein,
composition A contains 1wt% of licorice extract,
composition B contains 0.5wt% of cortex Ilicis Rotundae extract,
composition C contains 0.5wt% of Glycyrrhrizae radix extract and 0.5wt% of cortex Ilicis Rotundae extract.
Test 1
The Escherichia coli is respectively subjected to sterilization test by adopting the composition A, the composition B and the composition C with equal mass, the test time is 5min, and the test results are shown in Table 4.
TABLE 4
Test 2
The composition A, the composition B and the composition C with equal mass are respectively used for carrying out sterilization tests on staphylococcus aureus, the test time is 5min, and the test results are shown in table 5.
TABLE 5
Test 3
The candida albicans was respectively subjected to sterilization tests by using the compositions A, B and C with equal mass, the test time was 5min, and the test results are shown in Table 6.
TABLE 6
The results in tables 4-6 show that oral composition C containing both licorice extract and ovateleaf holly bark extract has significantly higher killing effect on three pathogenic bacteria than composition A containing licorice extract alone and composition B containing ovateleaf holly bark extract alone.
The oral composition can be used for killing pathogenic bacteria in the oral cavity to quickly diminish inflammation and prevent inflammatory infection.
Unless specifically stated otherwise, the numerical values set forth in these examples do not limit the scope of the invention. In all examples shown and described herein, unless otherwise specified, any particular value should be construed as merely illustrative, and not restrictive, and thus other examples of example embodiments may have different values.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.
Claims (3)
1. An oral composition comprising a licorice extract and an ovate leaf holly bark extract, wherein the oral composition is prepared from: 1wt% of licorice extract, 1wt% of ovate leaf holly bark extract, 54wt% of sorbitol, 0.2wt% of saccharin sodium, 0.23wt% of sodium fluoride, 1wt% of essence, 0.1wt% of methyl hydroxybenzoate, 0.05wt% of propyl hydroxybenzoate, PEG 4008 wt, 1wt% of thickening agent, 0.3wt% of titanium dioxide, 17wt% of silicon dioxide, K122 wt% and the balance of water; or
The oral composition is prepared from the following components: 5wt% of licorice extract, 2wt% of ovate leaf holly bark extract, 10wt% of sorbitol, 0.11wt% of saccharin sodium, 0.1wt% of sodium fluoride, 0.1wt% of essence, 0.1wt% of methyl paraben, 0.1wt% of propyl paraben, 201 wt% of tween-201 and the balance of water; or
The oral composition is prepared from the following components: 10wt% of licorice extract, 10wt% of ovate leaf holly bark extract, 0.1wt% of sorbitol, 0.01wt% of saccharin sodium, 0.05wt% of sodium fluoride, 0.05wt% of essence, 0.05wt% of methyl paraben, 0.05wt% of propyl paraben, 200.05 wt% of tween-1, and the balance of water; or
The oral composition is prepared from the following components: 10wt% of licorice extract, 10wt% of ovate leaf holly bark extract, 0.1wt% of sorbitol, 0.5wt% of saccharin sodium, 0.05wt% of sodium fluoride, 1.2wt% of essence, 0.18wt% of methyl paraben, 0.1wt% of propyl paraben and the balance of water.
2. Use of the oral composition of claim 1 in the manufacture of an oral care product having antibacterial and anti-inflammatory properties.
3. The use of claim 2, wherein the oral care product comprises a toothpaste, a mouthwash, or a breath freshener.
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