CN108653398B - Anti-allergy combined medicament special for tooth implantation process - Google Patents
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Abstract
The invention discloses an anti-allergy combined medicament special for a tooth implantation process, which comprises the following components: the composition comprises an antiallergic agent, a traditional Chinese medicine extract, potassium citrate, erythritol, sorbitol, N-lauroyl sarcosine sodium, carbomer and water. The anti-allergy combined medicament is special for the tooth implantation process, has no toxic or side effect, contains various Chinese herbal medicines, is added with the bioglass with bacteriostatic and hemostatic effects, accords with the traditional Chinese medicine and pharmacy and modern medicine and pharmacology theory, can effectively suppress bacteria, stop bleeding and prevent allergy, stabilizes the tissues around the wound surface, promotes the wound surface to heal and the regeneration of gum tissues, and can be used for stopping bleeding, diminishing inflammation and preventing allergy in the tooth implantation process.
Description
Technical Field
The invention relates to an anti-allergy combined medicament specially used in a tooth implantation process.
Background
A tooth is a hard but resilient calcium-containing tissue that mechanically supports the enamel. Dentine hypersensitivity is caused by various dental diseases such as abrasion (frequent hard-bite), fracture of teeth caused by trauma, wedge-shaped defect of tooth neck caused by improper long-term tooth brushing, dental caries, tooth root exposure caused by periodontal atrophy and the like, which can cause the integrity of enamel on the surface of teeth to be damaged and thus cause dentine exposure. Dentinal tubules are fluid filled and when the center of the tooth is exposed to the external environment, the pulp nerves are stimulated when subjected to air flow, tactile stimuli, or cold-hot stimuli, resulting in pain sensation.
At present, most of products for improving tooth sensitivity are toothpaste and mouthwash, and a special anti-allergic medicament in the tooth implantation process is lacked in the market. In general, fluoride is used in anti-allergy products to form a layer of hard fluorapatite on the surface of teeth through interaction with dentin of the teeth, thereby improving the hardness of enamel. The use of strontium chloride and potassium nitrate can significantly reduce the permeability of tooth tissues and reduce the sensitivity of gingival margin and periodontal tissues to various stimuli. The gel or colloid compound can mechanically close the mouth of dentinal tubule, and has antiallergic effect in short time. Bioactive glasses have attracted considerable attention since 1971 when discovered by professor Hench in the united states. On the one hand, the bioactive glass has the functions of hemostasis, antibiosis and antiphlogosis. On the other hand, compared with the traditional bioactive glass, the mesoporous bioactive glass shows better bone reconstruction capability and biocompatibility. The mesoporous bioglass has mesoporous pores (2-50nm), larger specific surface area and pore volume, and abundant surface silicon hydroxyl groups can provide more active sites, so that higher drug loading capacity can be achieved. The bioactive glass has a large number of application examples in toothpaste, and has good application prospect in tooth implantation. Traditional Chinese medicine treatment usually focuses on the overall regulation effect, focuses on the connection between local parts and the whole body, and focuses on the development of the disease resistance potential of a human body. The treatment method of strengthening body resistance and consolidating constitution is undoubtedly an important means for improving disease defense ability and improving organism immunity, and has more and more advantages in long-term clinical process by applying traditional Chinese medicine to prevent allergy. Therefore, the research on how to combine the traditional Chinese medicine treatment means with the porous bioglass material to be applied to the anti-allergy treatment of the patient in the tooth implantation process has good application prospect.
Disclosure of Invention
The invention provides an anti-allergy combined medicament specially used in a tooth implantation process. The invention adopts the following technical scheme:
an anti-allergic combination medicament special for a tooth implantation process comprises the following components:
the composition comprises an antiallergic agent, a traditional Chinese medicine extract, potassium citrate, erythritol, sorbitol, N-lauroyl sarcosine sodium, carbomer and water.
An anti-allergic combined medicament special for a tooth implantation process comprises the following components in parts by weight:
0.8-1.5 parts of antiallergic agent, 0.1-0.5 parts of traditional Chinese medicine extract, 0.05-0.15 parts of potassium citrate, 0.2-0.6 parts of erythritol, 2-8 parts of sorbitol, 0.06-0.3 parts of N-lauroyl sarcosine sodium, 0.5-3.5 parts of carbomer and 90-100 parts of water. The preparation method of the special anti-allergic combined medicament in the tooth implantation process comprises the following steps: adding the traditional Chinese medicine extract into water, stirring for 25-50 minutes at the temperature of 30-35 ℃ and the rotating speed of 200-.
An anti-allergic combined medicament special for a tooth implantation process comprises the following components in parts by weight:
0.8-1.5 parts of antiallergic agent, 0.1-0.5 parts of traditional Chinese medicine extract, 0.3-1 part of bioglass, 0.05-0.15 part of potassium citrate, 0.2-0.6 part of erythritol, 2-8 parts of sorbitol, 0.06-0.3 part of N-lauroyl sarcosine sodium, 0.5-3.5 parts of carbomer and 90-100 parts of water. The preparation method of the special anti-allergic combined medicament in the tooth implantation process comprises the following steps: adding the traditional Chinese medicine extract into water, stirring for 25-50 minutes at the temperature of 30-35 ℃ and the rotating speed of 200-.
The special anti-allergic combined medicament for the tooth implantation process comprises one of strontium chloride and strontium acetate.
The special anti-allergic combination medicament for the tooth implantation process, which is prepared from any one of the above components, wherein the carbomer is carbomer 940.
The special anti-allergic combined medicament for the tooth implantation process comprises the following steps of: mixing fructus forsythiae, ladybug, liquorice, asarum and radix sileris according to the mass ratio of 1 (1-2): 2-4): 1-2): 1-3, crushing, sieving by a sieve with 10-50 meshes to obtain traditional Chinese medicine powder, adding 20-35g of traditional Chinese medicine powder into 200mL of 100-fold water, adding 0.01-0.05g of mixed enzyme, uniformly mixing, heating to 35-37 ℃, keeping the temperature at 35-37 ℃ for 28-32h, heating to 95-100 ℃, keeping the temperature at 95-100 ℃ for 3-5 min, cooling to 28-32 ℃, sieving by a sieve with 100-fold 300 meshes to obtain primary filtrate and primary filter cake, adding the primary filter cake into 80-120mL of ethanol aqueous solution with the volume fraction of 60-75%, heating to 65-75 ℃, stirring at 65-75 ℃ and the rotation speed of 200-fold for 1-4 h, sieving the mixture through a 100-fold 300-mesh sieve to obtain a secondary filtrate and a secondary filter cake, combining the primary filtrate and the secondary filtrate to obtain a mixed filtrate, concentrating the mixed filtrate to 1/30-1/10 of the original mass, and drying the concentrated solution at 35-45 ℃ and 0.01-0.03MPa for 4-8 hours to obtain the traditional Chinese medicine extract, wherein the mixed enzyme is a mixture of cellulase, pectinase and neutral protease according to the mass ratio of (1-3) to (1-2). The step of concentrating the mixed filtrate to 1/30-1/10 of the original mass is to concentrate the mixed filtrate to 1/30-1/10 of the original mass at 45-55 ℃, 0.02-0.05MPa and the rotating speed of 10-50 r/min. The traditional Chinese medicines used in the invention are reasonably combined according to the theory of traditional Chinese medicine, and the extract of the traditional Chinese medicine has the functions of resisting bacteria, diminishing inflammation, stopping bleeding, easing pain and clearing heat.
The preparation method of the bioglass preferably comprises the following steps: (1) preparing a template agent: dissolving 1-2g of cellulose derivative and 0.05-0.15g N, N' -methylene bisacrylamide in 250-350g of water, stirring for 30-60 minutes at the temperature of 25-30 ℃ and the rotation speed of 100-300r/min, adding 1-3g of tert-butyl acrylate, heating to 35-40 ℃, adding 0.03-0.06g of initiator, stirring for 1-3 hours at the temperature of 35-40 ℃ and the rotation speed of 200-500r/min, cooling to 25-28 ℃, adjusting the pH to 8-9 by using a sodium hydroxide aqueous solution with the concentration of 0.1-0.5mol/L, stirring for 0.5-1.5 hours at the temperature of 25-28 ℃ and the rotation speed of 300-500 r/min, and then centrifuging for 10-30 minutes at the rotation speed of 8000-12000 r/min, taking the precipitate obtained by centrifugation, and placing the precipitate in a drying oven at 40-45 ℃ for drying for 4-8 hours to obtain a template agent; (2) uniformly mixing 2-3mg of template agent, 200-300mL of water and 200-300mL of ethanol, heating to 38-42 ℃, adding 0.5-1g of hexadecyl trimethyl ammonium bromide and 8-12mL of ammonia water with the mass fraction of 25-28%, stirring at 38-42 ℃ and the rotating speed of 200-500r/min for 10-40 minutes to obtain a mixture, dissolving 5-10g of tetraethyl silicate and 0.4-0.8g of triethyl phosphate in 250-350mL of anhydrous ethanol, adding the mixture into the mixture, stirring at 38-42 ℃ and the rotating speed of 200-500r/min for 150 minutes, adding 3-4g of calcium chloride, continuously stirring for 36-52 hours under the conditions, and then centrifuging at 5000-10000r/min for 10-30 minutes, washing the centrifugal precipitate with 400-600g ethanol, drying at 50-70 ℃ for 18-26 hours, then placing in a muffle furnace, raising the temperature to 800-900 ℃ at the speed of 8-12 ℃/min, preserving the temperature at 800-900 ℃ for 1.5-2.5 hours, and naturally cooling to obtain the bioglass. In the step (1), the initiator is potassium persulfate. In the step (1), the cellulose derivative is hydroxypropyl cellulose and/or hydroxyethyl cellulose. The cellulose derivative is more preferably a mixture of hydroxypropyl cellulose and hydroxyethyl cellulose, and the mass ratio of the hydroxypropyl cellulose to the hydroxyethyl cellulose is (1-3): (1-3) preparing template agents with different structures by adjusting the types and the proportions of the cellulose derivatives, and finally influencing the particle size and the pore structure of the product bioglass. The bioglass used in the invention has larger specific surface area and small particle size. In one aspect, bioglass can inhibit sensitive teeth and ameliorate or reduce pain by sealing dentinal tubules, occluding sensitive ducts. On the other hand, the bioglass has the functions of hemostasis, antibiosis and antiphlogosis. In addition, the pore structure of the bioglass can better slowly release the medicine components, and the effect of acting on teeth and gum for a long time is achieved.
The anti-allergy combined medicament is special for the tooth implantation process, has no toxic or side effect, contains various Chinese herbal medicines and bioglass with antibacterial and hemostatic effects, accords with the traditional Chinese medicine and pharmacology theory and modern medicine and pharmacology theory, can effectively inhibit bacteria, stop bleeding and prevent allergy, stabilizes the tissues around the wound surface, promotes the wound surface to heal and the regeneration of gum tissues, and can be used for stopping bleeding, diminishing inflammation and preventing allergy in the tooth implantation process.
Detailed Description
The main raw materials used in the following examples are as follows:
forsythia suspensa (Forsythia Suspensa, Thunb.) dried fruit of Vahl, a plant belonging to the family Oleaceae. Has the effects of clearing away heat and toxic materials, relieving swelling, and dispersing pathogenic accumulation.
Calamine grandis, dry root of Calamine grandis Cynanchum inamoenum (Maxim.) Lose. Has effects in clearing away heat, cooling blood, relieving fever, and relieving restlessness.
Glycyrrhrizae radix is dried root of Glycyrrhiza inflata Bat of Leguminosae. Has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, and relieving spasm and pain.
Asarum sieboldii, a dried whole plant of Asarum heterotropoides Fr. Has effects of dispelling pathogenic wind and cold, inducing resuscitation and relieving pain, warming lung and eliminating fluid retention.
Ledebouriella root, a dried root of the plant Saposhnikovia divaricata (Turcz.) switzerland, of the family umbelliferae, schischchk. Has the effects of relieving exterior syndrome, dispelling pathogenic wind, eliminating dampness, and relieving spasm.
Strontium acetate, CAS No.: 543-94-2.
Hydroxypropyl cellulose, CAS No.: 9004-64-2, m.w.: 100000. purchased from Shanghai Aladdin Biotechnology, Inc., product number H113415.
Hydroxyethyl cellulose, CAS No.: 9004-62-0, 25 ℃ viscosity (2% aqueous solution): 3400-5000 mpa.s. Specifically purchased from Shanghai Aladdin Biotechnology, Inc., product number H104788.
Tert-butyl acrylate, CAS number: 1663-39-4.
Calcium chloride, CAS number: 10043-52-4.
Potassium citrate, CAS No.: 866-84-2.
Sorbitol, CAS No.: 50-70-4.
Carbomer 940, luobu usa.
25 to 28 percent of ammonia water which is purchased from Shanghai Aladdin Biotechnology GmbH, product number A112077.
Cellulase, CAS number: 9012-54-8. The cellulase used in the embodiment of the invention is a high-efficiency cellulase preparation which is refined by trichoderma reesei (Latin chemical name: Trichodermareesei) through procedures of liquid submerged fermentation, ultrafiltration and the like, and specifically uses cellulase with the type of full-component 7000, and the enzyme activity is as follows: 7000u/g, purchased from Ningxia Xiesheng industry group Co.
Pectinase with the enzyme activity of 1 wu/g is purchased from Ningxia Xiesheng industry group Co., Ltd, model SAC-015.
Neutral protease, CAS No.: 9068-59-1. Enzyme activity: 50 u/mg. Purchased from Shanghai Aladdin Biotechnology, Inc., product number: D195752.
the invention is further illustrated by the following examples.
Example 1
An anti-allergic combined medicament special for a tooth implantation process comprises the following components in parts by weight:
1 part of antiallergic agent, 0.3 part of traditional Chinese medicine extract, 0.1 part of potassium citrate, 0.3 part of erythritol, 5 parts of sorbitol, 0.1 part of sodium N-lauroyl sarcosinate, 3 parts of carbomer 940 and 93 parts of water. The antiallergic agent is strontium acetate.
The preparation method of the traditional Chinese medicine extract comprises the following steps: mixing fructus forsythiae, ladybug, liquorice, asarum and radix sileris according to the mass ratio of 1:1:3:2:1, crushing, sieving with a 30-mesh sieve to obtain traditional Chinese medicine powder, adding 32g of the traditional Chinese medicine powder into 150mL of water, adding 0.02g of mixed enzyme, uniformly mixing, heating to 36 ℃, keeping the temperature at 36 ℃ for 30h, heating to 98 ℃, keeping the temperature at 98 ℃ for 3 min, cooling to 30 ℃, sieving with a 100-mesh sieve to obtain a primary filtrate and a primary filter cake, adding the primary filter cake into 100mL of 65 volume percent ethanol aqueous solution, heating to 70 ℃, stirring at 70 ℃ and 300r/min for 3 h, sieving with a 100-mesh sieve to obtain a secondary filtrate and a secondary filter cake, combining the primary filtrate and the secondary filtrate to obtain a mixed filtrate, concentrating the mixed filtrate at 50 ℃, 0.04MPa and 30r/min to 1/20 of the original mass, drying the concentrated solution at 40 ℃ and 0.01MPa for 6 h, the traditional Chinese medicine extract is obtained, and the mixed enzyme is a mixture of cellulase, pectinase and neutral protease according to the mass ratio of 2:1: 1.
The preparation method of the special anti-allergic combined medicament in the tooth implantation process comprises the following steps: adding the traditional Chinese medicine extract into water, stirring for 30 minutes at the temperature of 35 ℃ and the rotating speed of 300r/min, adding the antiallergic agent, potassium citrate, erythritol, sorbitol, N-lauroyl sarcosine sodium and carbomer 940, and continuously stirring for 50 minutes under the above conditions to obtain the special antiallergic combination medicament for the tooth implantation process.
Example 2
An anti-allergic combined medicament special for a tooth implantation process comprises the following components in parts by weight:
1 part of antiallergic agent, 0.3 part of traditional Chinese medicine extract, 0.5 part of bioglass, 0.1 part of potassium citrate, 0.3 part of erythritol, 5 parts of sorbitol, 0.1 part of N-lauroyl sarcosine sodium, 3 parts of carbomer 940 and 93 parts of water. The antiallergic agent is strontium acetate. The preparation method of the traditional Chinese medicine extract is the same as that of the example 1.
The preparation method of the bioglass comprises the following steps: (1) preparing a template agent: dissolving 1.2g of cellulose derivative and 0.1g N, N' -methylene bisacrylamide in 300g of water, stirring for 40 minutes at 25 ℃ and the rotation speed of 200r/min, adding 1.5g of tert-butyl acrylate, heating to 35 ℃, adding 0.04g of potassium persulfate, stirring for 2 hours at 35 ℃ and the rotation speed of 300r/min, cooling to 25 ℃, adjusting the pH to 8.5 by using a 0.2mol/L sodium hydroxide aqueous solution, stirring for 1 hour at 25 ℃ and the rotation speed of 300r/min, centrifuging for 20 minutes at 10000r/min, taking the precipitate obtained by centrifugation, and drying for 6 hours in a drying box at 40 ℃ to obtain a template agent; (2) uniformly mixing 2.5mg of template agent, 250mL of water and 250mL of ethanol, heating to 40 ℃, adding 0.7g of hexadecyl trimethyl ammonium bromide and 10mL of ammonia water with the mass fraction of 25-28%, stirring at 40 ℃ and the rotating speed of 300r/min for 20 minutes to obtain a mixture, dissolving 8g of tetraethyl silicate and 0.65g of triethyl phosphate in 300mL of absolute ethanol, adding the mixture into the mixture, stirring at 40 ℃ and the rotating speed of 300r/min for 120 minutes, adding 3.5g of calcium chloride, continuously stirring under the above conditions for 48 hours, centrifuging at 8000r/min for 20 minutes, washing the centrifugal precipitate with 500g of ethanol, drying at 60 ℃ for 24 hours, then placing in a muffle furnace, heating to 850 ℃ at the speed of 10 ℃/min, preserving heat at 850 ℃ for 2 hours, and naturally cooling to obtain the bioglass. The cellulose derivative is a mixture of hydroxypropyl cellulose and hydroxyethyl cellulose, and the mass ratio of the hydroxypropyl cellulose to the hydroxyethyl cellulose is 1: 1.
The preparation method of the special anti-allergic combined medicament in the tooth implantation process comprises the following steps: adding the traditional Chinese medicine extract into water, stirring for 30 minutes at the temperature of 35 ℃ and the rotating speed of 300r/min, adding bioglass, continuing to stir for 30 minutes under the conditions, adding an antiallergic agent, potassium citrate, erythritol, sorbitol, N-lauroyl sarcosine sodium and carbomer 940, continuing to stir for 50 minutes under the conditions, and obtaining the special antiallergic combination medicament in the tooth implantation process.
Example 3
An anti-allergic combined medicament special for a tooth implantation process comprises the following components in parts by weight:
1 part of antiallergic agent, 0.3 part of traditional Chinese medicine extract, 0.5 part of bioglass, 0.1 part of potassium citrate, 0.3 part of erythritol, 5 parts of sorbitol, 0.1 part of N-lauroyl sarcosine sodium, 3 parts of carbomer 940 and 93 parts of water. The antiallergic agent is strontium acetate. The preparation method of the traditional Chinese medicine extract is the same as that of the example 1.
The preparation method of the bioglass comprises the following steps: (1) preparing a template agent: dissolving 1.2g of cellulose derivative and 0.1g N, N' -methylene bisacrylamide in 300g of water, stirring for 40 minutes at 25 ℃ and the rotation speed of 200r/min, adding 1.5g of tert-butyl acrylate, heating to 35 ℃, adding 0.04g of potassium persulfate, stirring for 2 hours at 35 ℃ and the rotation speed of 300r/min, cooling to 25 ℃, adjusting the pH to 8.5 by using a 0.2mol/L sodium hydroxide aqueous solution, stirring for 1 hour at 25 ℃ and the rotation speed of 300r/min, centrifuging for 20 minutes at 10000r/min, taking the precipitate obtained by centrifugation, and drying for 6 hours in a drying box at 40 ℃ to obtain a template agent; (2) uniformly mixing 2.5mg of template agent, 250mL of water and 250mL of ethanol, heating to 40 ℃, adding 0.7g of hexadecyl trimethyl ammonium bromide and 10mL of ammonia water with the mass fraction of 25-28%, stirring at 40 ℃ and the rotating speed of 300r/min for 20 minutes to obtain a mixture, dissolving 8g of tetraethyl silicate and 0.65g of triethyl phosphate in 300mL of absolute ethanol, adding the mixture into the mixture, stirring at 40 ℃ and the rotating speed of 300r/min for 120 minutes, adding 3.5g of calcium chloride, continuously stirring under the above conditions for 48 hours, centrifuging at 8000r/min for 20 minutes, washing the centrifugal precipitate with 500g of ethanol, drying at 60 ℃ for 24 hours, then placing in a muffle furnace, heating to 850 ℃ at the speed of 10 ℃/min, preserving heat at 850 ℃ for 2 hours, and naturally cooling to obtain the bioglass. The cellulose derivative is only hydroxypropyl cellulose.
The preparation method of the special anti-allergic combined medicament in the tooth implantation process comprises the following steps: adding the traditional Chinese medicine extract into water, stirring for 30 minutes at the temperature of 35 ℃ and the rotating speed of 300r/min, adding bioglass, continuing to stir for 30 minutes under the conditions, adding an antiallergic agent, potassium citrate, erythritol, sorbitol, N-lauroyl sarcosine sodium and carbomer 940, continuing to stir for 50 minutes under the conditions, and obtaining the special antiallergic combination medicament in the tooth implantation process.
Example 4
An anti-allergic combined medicament special for a tooth implantation process comprises the following components in parts by weight:
1 part of antiallergic agent, 0.3 part of traditional Chinese medicine extract, 0.5 part of bioglass, 0.1 part of potassium citrate, 0.3 part of erythritol, 5 parts of sorbitol, 0.1 part of N-lauroyl sarcosine sodium, 3 parts of carbomer 940 and 93 parts of water. The antiallergic agent is strontium acetate. The preparation method of the traditional Chinese medicine extract is the same as that of the example 1.
The preparation method of the bioglass comprises the following steps: (1) preparing a template agent: dissolving 1.2g of cellulose derivative and 0.1g N, N' -methylene bisacrylamide in 300g of water, stirring for 40 minutes at 25 ℃ and the rotation speed of 200r/min, adding 1.5g of tert-butyl acrylate, heating to 35 ℃, adding 0.04g of potassium persulfate, stirring for 2 hours at 35 ℃ and the rotation speed of 300r/min, cooling to 25 ℃, adjusting the pH to 8.5 by using a 0.2mol/L sodium hydroxide aqueous solution, stirring for 1 hour at 25 ℃ and the rotation speed of 300r/min, centrifuging for 20 minutes at 10000r/min, taking the precipitate obtained by centrifugation, and drying for 6 hours in a drying box at 40 ℃ to obtain a template agent; (2) uniformly mixing 2.5mg of template agent, 250mL of water and 250mL of ethanol, heating to 40 ℃, adding 0.7g of hexadecyl trimethyl ammonium bromide and 10mL of ammonia water with the mass fraction of 25-28%, stirring at 40 ℃ and the rotating speed of 300r/min for 20 minutes to obtain a mixture, dissolving 8g of tetraethyl silicate and 0.65g of triethyl phosphate in 300mL of absolute ethanol, adding the mixture into the mixture, stirring at 40 ℃ and the rotating speed of 300r/min for 120 minutes, adding 3.5g of calcium chloride, continuously stirring under the above conditions for 48 hours, centrifuging at 8000r/min for 20 minutes, washing the centrifugal precipitate with 500g of ethanol, drying at 60 ℃ for 24 hours, then placing in a muffle furnace, heating to 850 ℃ at the speed of 10 ℃/min, preserving heat at 850 ℃ for 2 hours, and naturally cooling to obtain the bioglass. The cellulose derivative is only hydroxyethyl cellulose.
The preparation method of the special anti-allergic combined medicament in the tooth implantation process comprises the following steps: adding the traditional Chinese medicine extract into water, stirring for 30 minutes at the temperature of 35 ℃ and the rotating speed of 300r/min, adding bioglass, continuing to stir for 30 minutes under the conditions, adding an antiallergic agent, potassium citrate, erythritol, sorbitol, N-lauroyl sarcosine sodium and carbomer 940, continuing to stir for 50 minutes under the conditions, and obtaining the special antiallergic combination medicament in the tooth implantation process.
Comparative example 1
Essentially the same as example 2, except that: in this comparative example 1:
the preparation method of the bioglass comprises the following steps: uniformly mixing 250mL of water and 250mL of ethanol, heating to 40 ℃, adding 0.7g of hexadecyl trimethyl ammonium bromide and 10mL of ammonia water with the mass fraction of 25% -28%, stirring at 40 ℃ and the rotating speed of 300r/min for 20 minutes to obtain a mixture, dissolving 8g of tetraethyl silicate and 0.65g of triethyl phosphate in 300mL of anhydrous ethanol, then adding the mixture into the mixture, stirring at 40 ℃ and the rotating speed of 300r/min for 120 minutes, adding 3.5g of calcium chloride, continuing stirring under the conditions for 48 hours, then centrifuging at 8000r/min for 20 minutes, washing the centrifugal precipitate with 500g of ethanol, drying at 60 ℃ for 24 hours, then placing in a muffle furnace, heating to 850 ℃ at the speed of 10 ℃/min, preserving the temperature at 850 ℃ for 2 hours, and naturally cooling to obtain the bioglass.
Comparative example 2
An anti-allergic combined medicament special for a tooth implantation process comprises the following components in parts by weight:
1 part of antiallergic agent, 0.5 part of bioglass, 0.1 part of potassium citrate, 0.3 part of erythritol, 5 parts of sorbitol, 0.1 part of sodium N-lauroyl sarcosinate, 3 parts of carbomer 940 and 93 parts of water. The antiallergic agent is strontium acetate.
The preparation method of the bioglass is the same as that of the example 2.
The preparation method of the special anti-allergic combined medicament in the tooth implantation process comprises the following steps: adding bioglass into water, stirring at 35 ℃ and the rotating speed of 300r/min for 30 minutes, adding an antiallergic agent, potassium citrate, erythritol, sorbitol, N-lauroyl sarcosine sodium and carbomer 940, and continuously stirring for 50 minutes under the conditions to obtain the special antiallergic combination medicament for the tooth implantation process.
Test example
The method comprises the following steps of (I) testing bacteriostatic effect:
experimental groups: adding 9mL of special anti-allergic combined medicament in the tooth implantation process into a sterile glass test tube, and adding 1mL of Escherichia coli liquid (with photometric value (O.D) of 0.1 and colony count of 10)6CFU/mL), mixing uniformly, placing in a constant temperature incubator at 37 ℃ for culturing for 12 hours, and measuring the light absorption value of the mixed solution in the sterile test tube after culturing. Control group: the above experiment was carried out using 9mL of physiological saline instead of the anti-allergic combination preparation exclusively used in the tooth implantation procedure. The formula for calculating the bacteriostasis rate is as follows: (absorbance after culture of control group-absorbance after culture of experimental group)/absorbance after culture of control group × 100%. The test results are shown in Table 1.
Table 1: bacteriostatic rate test result table
(II) testing the curative effect of periodontitis:
patient data: 300 patients, 150 men and 150 women. The examination shows that the symptoms of the patient are simple redness and swelling of the gum, dark redness of the gum ditch, deepening of the gum ditch, pus discharge of the gum ditch, erosion of the gum margin, severe bleeding of the gum and hyperemia and edema of the gum. In all cases, there was no loose teeth. Before treatment, no anti-inflammatory drugs are taken. 300 patients were divided into 6 groups of 50 patients each, including 25 males and 25 females. The patients in the 6 groups have no significant difference in age and disease condition and are comparable.
The treatment method comprises the following steps: the anti-allergy combined medicament is specially used for spraying the anti-allergy combined medicament to the inflamed tooth root of a patient each time in the tooth implantation process, and 0.3mL of the anti-allergy combined medicament is sprayed to the corresponding part of each tooth. The medicine is taken in the morning and at night.
The curative effect standard is as follows: the effect is shown: after 1-3 days, gingival bleeding stops, gingival hyperemia and edema basically subsides, and halitosis disappears. The method has the following advantages: after the medicine is taken for 3 to 7 days, the gum bleeding stops, the red swelling basically subsides, and the halitosis is obviously reduced or disappeared. And (4) invalidation: the symptoms are not obviously improved after 7 days of administration.
Table 2: periodontitis curative effect test result table
| Show effect | Is effective | Invalidation | |
| Example 1 | 26 | 18 | 6 |
| Example 2 | 38 | 12 | 0 |
| Example 3 | 33 | 15 | 2 |
| Example 4 | 30 | 18 | 2 |
| Comparative example 1 | 27 | 19 | 4 |
| Comparative example 2 | 25 | 20 | 5 |
The anti-allergy combined medicament is special for the tooth implantation process, has no toxic or side effect, contains various Chinese herbal medicines, is added with bioglass with bacteriostatic and hemostatic effects, accords with the traditional Chinese medicine and modern medicine theory, can effectively inhibit bacteria, stop bleeding and prevent allergy, stabilizes the tissues around the wound surface, promotes the wound surface to heal and the regeneration of gum tissues, and can be used for stopping bleeding, diminishing inflammation and preventing allergy in the tooth implantation process.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.
Claims (5)
1. The special anti-allergic combined medicament for the tooth implantation process is characterized by comprising the following components in parts by weight:
0.8-1.5 parts of antiallergic agent, 0.1-0.5 parts of traditional Chinese medicine extract, 0.3-1 part of bioglass, 0.05-0.15 part of potassium citrate, 0.2-0.6 part of erythritol, 2-8 parts of sorbitol, 0.06-0.3 part of N-lauroyl sarcosine sodium, 0.5-3.5 parts of carbomer and 90-100 parts of water;
the preparation method of the traditional Chinese medicine extract comprises the following steps: mixing fructus forsythiae, ladybug, liquorice, asarum and radix sileris according to the mass ratio of 1 (1-2): 2-4): 1-2): 1-3, crushing, sieving by a sieve with 10-50 meshes to obtain traditional Chinese medicine powder, adding 20-35g of traditional Chinese medicine powder into 200mL of 100-fold water, adding 0.01-0.05g of mixed enzyme, uniformly mixing, heating to 35-37 ℃, keeping the temperature at 35-37 ℃ for 28-32h, heating to 95-100 ℃, keeping the temperature at 95-100 ℃ for 3-5 min, cooling to 28-32 ℃, sieving by a sieve with 100-fold 300 meshes to obtain primary filtrate and primary filter cake, adding the primary filter cake into 80-120mL of ethanol aqueous solution with the volume fraction of 60-75%, heating to 65-75 ℃, stirring at 65-75 ℃ and the rotation speed of 200-fold for 1-4 h, sieving with a 100-fold 300-mesh sieve to obtain a secondary filtrate and a secondary filter cake, combining the primary filtrate and the secondary filtrate to obtain a mixed filtrate, concentrating the mixed filtrate to 1/30-1/10 of the original mass, and drying the concentrated solution at 35-45 ℃ and 0.01-0.03MPa for 4-8 hours to obtain a traditional Chinese medicine extract, wherein the mixed enzyme is a mixture of cellulase, pectinase and neutral protease according to the mass ratio of (1-3) to (1-2);
the antiallergic agent is one of strontium chloride and strontium acetate;
the preparation method of the bioglass comprises the following steps: (1) preparing a template agent: dissolving 1-2g of cellulose derivative and 0.05-0.15g N, N' -methylene bisacrylamide in 350g of water of 250-350g, stirring for 30-60 minutes at the temperature of 25-30 ℃ and the rotation speed of 100-300r/min, adding 1-3g of tert-butyl acrylate, heating to 35-40 ℃, adding 0.03-0.06g of initiator, stirring for 1-3 hours at the temperature of 35-40 ℃ and the rotation speed of 200-500r/min, cooling to 25-28 ℃, adjusting the pH to 8-9 by using a sodium hydroxide aqueous solution with the concentration of 0.1-0.5mol/L, stirring for 0.5-1.5 hours at the temperature of 25-28 ℃ and the rotation speed of 300-500 r/min, centrifuging for 10-30 minutes at the rotation speed of 8000-12000 r/min, taking the precipitate obtained by centrifugation, drying in a drying oven at 40-45 deg.C for 4-8 hr to obtain template agent; (2) uniformly mixing 2-3mg of template agent, 200-300mL of water and 200-300mL of ethanol, heating to 38-42 ℃, adding 0.5-1g of hexadecyl trimethyl ammonium bromide and 8-12mL of ammonia water with the mass fraction of 25-28%, stirring at the temperature of 38-42 ℃ and the rotation speed of 200-500r/min for 10-40 minutes to obtain a mixture, dissolving 5-10g of tetraethyl silicate and 0.4-0.8g of triethyl phosphate in 250-350mL of anhydrous ethanol, adding the mixture, stirring at the temperature of 38-42 ℃ and the rotation speed of 200-500r/min for 150 minutes, adding 3-4g of calcium chloride, continuously stirring for 36-52 hours under the conditions, then centrifuging at the speed of 5000-10000r/min for 10-30 minutes, washing the centrifugal precipitate with 400-600g of ethanol, drying at the temperature of 50-70 ℃ for 18-26 hours, then placing the mixture in a muffle furnace, raising the temperature to 900 ℃ at the speed of 8-12 ℃/min, preserving the temperature for 1.5-2.5h at 900 ℃ of 800-.
2. The anti-allergic combination medicament special for tooth implantation according to claim 1, wherein the carbomer is carbomer 940.
3. The special anti-allergic combination medicament for tooth implantation according to claim 1, wherein the cellulose derivative is hydroxypropyl cellulose and/or hydroxyethyl cellulose.
4. The special anti-allergic combination medicament for the tooth implantation process according to claim 3, wherein the cellulose derivative is a mixture of hydroxypropyl cellulose and hydroxyethyl cellulose, and the mass ratio of the hydroxypropyl cellulose to the hydroxyethyl cellulose is (1-3): (1-3).
5. The special antiallergic combination drug for dental implantation according to claim 1, wherein the initiator is potassium persulfate.
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