CN103340896A - Duplex dentin hypersensitivity resistant composition and application thereof - Google Patents
Duplex dentin hypersensitivity resistant composition and application thereof Download PDFInfo
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- CN103340896A CN103340896A CN2013102894907A CN201310289490A CN103340896A CN 103340896 A CN103340896 A CN 103340896A CN 2013102894907 A CN2013102894907 A CN 2013102894907A CN 201310289490 A CN201310289490 A CN 201310289490A CN 103340896 A CN103340896 A CN 103340896A
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Abstract
The invention discloses a duplex dentin hypersensitivity resistant composition and an application of the composition. The active ingredients of the duplex dentin hypersensitivity resistant composition include a potassium salt and titanium containing bioactive glass, wherein the weight percentage of the potassium salt in the composition is 0.3-12%, and the weight percentage of the titanium containing bioactive glass in the composition is 0.5-15%. The duplex dentin hypersensitivity resistant composition disclosed by the invention can be used for preventing and treating (eliminating or relieving) dentin hypersensitivity; on one side, the potassium salt releases potassium ions to rapidly relieve pain (by reducing the excitability of a dental pulp nerve), on the other side, the bioactive glass can be used for supplementing minerals for a tooth structure to form stable carbonated hydroxyapatite so as to deeply close a dentinal tubule (by improving the permeability of the dentinal tubule); treatment effect is greatly improved, and aching feeling and anaphylaxis can be radically eliminated to achieve the purposes of treating both symptoms and root causes; in addition, as the bioactive glass comprises titanium, the phosphorite layer formed on the surface of a tooth is firmer and more wear-resistant, and the tooth can better resist daily stimulation.
Description
Technical field
The present invention relates to a kind of compositions of dual anti-dentin hypersensitiveness, said composition comprises titaniferous bioactivity glass and potassium salt, can be used for prevention and treatment (eliminate or alleviate) dentin hypersensitiveness.
Background technology
Dentin hypersensitiveness is the more common symptom of dental disease, refers to that the dentin that exposes is subjected to (machinery, chemistry, temperature and osmotic pressure etc.) environmental stimuli and a kind of special symptom of aching that produces.Dentin hypersensitiveness's sickness rate is 8%-30%, is the group of people at high risk about 40 years old, is commonly encountered diseases, the frequently-occurring disease of clinical oral.The symptom that dentin hypersensitiveness relates to and inducement are comparatively extensive, as: wedge shaped defect, periodontal atrophy, root of the tooth exposure, tooth trauma, dentin expose, serious wearing and tearing, tooth preparation, hole type preparation, toothwash, scaling, tooth decolours, transfers jaw etc.The main pathogenic factor of dental hypersensitiveness is when situation such as the impaired or gingival atrophy of enamel takes place, the dentinal tubule that exposes is open state, air, hyperosmotic solution or thermal stimulus make the liquid generation change in flow in the dentinal tubule, mechanically stir the dental pulp content, and then indirect excitation free nerve endings wherein, cause impulsion, produce the pain sensation.
The dental pulp disease expert has proposed six aspects for the treatment of dentin hypersensitiveness: 1. physical method seals or stops up the outer end of dentinal tubule; 2. chemical method is solidified the protoplasm of dentinal tubule; 3. the reaction of chemical substance and dental tissue forms precipitation, stops up tubule; 4. induce dentin to form, the nearly marrow end of sealing dentinal tubule; 5. anaesthetize speciality and infiltrate dental pulp through tubule, blocking-up dental pulp nerve ending; 6. some materials infiltrate dental pulp through tubule, suppress exciting of dental pulp nerve.These six rules and regulations are received 2 points: the one, change the permeability of dentinal tubule; The 2nd, the irritability of reduction dental pulp nerve.
Bioactivity glass was found by U.S. professor Hench in 1969, is a kind of bioactive materials.As everyone knows, the existing osteogenesis of bioactivity glass has the bone guided effect again, with osseous tissue and soft tissue good binding is arranged, and it is considered to can be applicable to the good biological material in reparation field.Reaction rapid, that continue can take place with water and saliva in bioactivity glass, discharge calcium ion and phosphate anion, replenish the dental structure mineral, be deposited in the dentinal tubule or on, long term can produce the stable crystalline hydroxyapatite layer and insert dentinal tubule, and sealing dentinal tubule induces new dentium nitor face to form, change the permeability of dentinal tubule, reduce dentin hypersensitiveness's reaction.Can form one deck stable crystalline hydroxyapatite layer at dental surface because of it again, can fill up effectively that bone is damaged, enamel, dentin defect, form area of new bone, it is damaged fundamentally to change the bone that occurs on the tooth, and then can fundamentally eliminate the phenomenon of dentin hypersensitiveness.
Titanium is a kind of body trace element, has good high-temperature capability, low-temperature flexibility and fracture toughness, can stimulate phagocyte, and immunity is strengthened.Intensity height, the corrosion stability of titanium alloy are good, and be strong especially to the resistance of spot corrosion, acid etching, stress corrosion, and organic article of alkali, chloride, chlorine, nitric acid, sulphuric acid etc. are had good resistance to corrosion.Titanium or titanium alloy has especially special nature at medical field: 1) titanium can form the good titanium dioxide passivating film of biocompatibility rapidly in air and blood, and directly do not contact with when injected organism tissue, thereby have dysgenic advantage can not arranged to the metabolism of implant; 2) but the decay resistance in air and physiological environment makes the implant life-time service; 3) prepare different structural interfaces, optimization pattern and porosity easily to satisfy the needs of live body receptor tissue; 4) do not find anaphylaxis up to now.Titanium oxide adds in the bioceramic material, and its biocompatibility, stiffness, wearability, corrosion stability are improved.Titanium oxide is applied to existing a lot of researchs in the bone renovating material.The bioceramic material that contains titanium oxide of the warm ripple research of Jilin University's stomatological hospital may be used on Wistar neonatal rat parietal bone, find that this material has good cell compatibility (Wen Bo, Huang Ying, Xu Yongzhong. the research [J] of the titanium oxide bioceramic osteocyte compatibility. Jilin University's journal (medicine) was rolled up 418 pages of the 3rd phases in 2004 the 30th).The calcium phosphate bioceramic coating that contains titanium oxide of the preparations such as Wang Yaming of Harbin University of Science and Technology's special cermacis institute has the good osteogenesis characteristic (Wang Yaming that lures, Zhou Yu, the Judd is prosperous etc., the differential arc oxidation method prepares titania based porous composite boilogical ceramic coating [J], Rare Metals Materials and engineering, volume was 1244 pages in 2005 the 34th).
The mechanism of potassium salt desensitization is: potassium ion contained in the potassium salt discharges, potassium ion enters into Dentinal tubule, with teleneuron affinity interaction is arranged, improve the transmission of Nerve impulse, signal by inhibition of Chemical Reaction teleneuron conduction pain has suppressed the remineralization of dental nerve, thereby has reduced the dental pulp nerve to hot and cold, sour, sweet irritability and sensitivity, anesthesia dental pulp nerve, alleviating pain.If use a period of time continuously, can make that potassium ion reaches certain dynamic equilibrium in the dentinal tubule, effect is continuous and effective more.
Patent documentation U.S.3863006 discloses and has comprised for example toothpaste of potassium nitrate of potassium salt, has reduced the sensitivity of tooth after several weeks of brushing teeth.Those skilled in the art believe that it is to produce that topical application comprises the dental products of potassium nitrate and the reason of bringing the therapeutic desensitization that near the extracellular potassium concentration the dental pulp nerve under the hypersensitive dentine raises.But independent potassium ion can not inaccessible dentinal tubule, is necessary to reuse potassium salt, to set up necessary concentration near the dental pulp nerve, to reduce the irritability of dental pulp nerve, alleviating pain.
Patent documentation CN1306416A discloses a kind of two component desensitizing toothpaste compositionss, and this dentifrice composition comprises a kind of potassium salt and a kind of tin salt.During use these two kinds of compositions are mixed use by proportioning.Therefore this invention is used inconvenient because two kinds of salts use simultaneously, and therefore the mastic instability of toothpaste can not be applied in the same pipe toothpaste.
Patent documentation CN101407373B discloses a kind of strontium-reinforced bioactivity glass glass, uses it for the manufacturing of dentifrice-toothpaste, can obviously play the effect of symptoms such as anti-dental hypersensitiveness, gingival hemorrhage and anti-plaque.But if only play time spent of doing of enhanced biological glass, the cost of strontium oxide is higher, and strontium oxide meets water and emit big calorimetric, can decompose gradually with air, and is unstable.
Patent documentation CN100536812C discloses a kind of energy elimination or has alleviated the two component tooth composites that do not accommodate pain relevant with dentin hypersensitiveness, wherein compositions comprises with first toothpaste component with neutral pH of alkali metal phosphate buffer pH in 6.5 to 7.5 scopes, second toothpaste component with alkaline pH of pH in 8 to 12 scopes, and at least one component comprises the sodium fluoride that is selected from of energy releasing fluoride ion, potassium fluoride, sodium monofluorophosphate, the salt of stannous fluoride and prodan and the potassium nitrate that is selected from that can discharge potassium ion, potassium citrate, potassium chloride, the salt of potassium bicarbonate and potassium oxalate, first and second components keep each other separating until preparation and unite on the tooth that is used in requirement alleviation dentin hypersensitiveness, and user finds that desensitization strengthens thus.But said composition belongs to toothpaste with fluoride, and human body is had certain harm, and this compositions can not be from repairing the open dentinal tubule in irritated position in essence.
Though prior art discloses multiple compositions for prevention and treatment dentin hypersensitiveness, cure the symptoms, not the disease, can produce dependency and the more high shortcoming of price but these compositionss have, need still therefore to develop that curative effect strengthens, the compositions that is used for prevention and treatment dentin hypersensitiveness for the treatment of both the principal and secondary aspects of a disease.
Summary of the invention
The purpose of this invention is to provide that a kind of curative effect strengthens, the compositions of the dual anti-dentin hypersensitiveness that comprises two kinds of effective ingredient that is used for prevention and treatment (eliminate or alleviate) dentin hypersensitiveness for the treatment of both the principal and secondary aspects of a disease.
The compositions of dual anti-dentin hypersensitiveness provided by the present invention, its effective ingredient are to account for the potassium salt of composition weight percentage ratio 0.3%-12% and the titaniferous bioactivity glass of 0.5%-15%.
In the potassium salt of provided potassium ion source of glycerol or water one or more are provided for potassium nitrate, potassium chloride, potassium citrate, potassium oxalate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate and potassium bicarbonate etc. described potassium salt.
Described titaniferous bioactivity glass is the graininess bioactivity glass, and particle diameter in weight ratio, wherein contains following glass ingredient less than 100 μ m:
After described bioactivity glass and water or physiological solution are had an effect, can generate hydroxyapatite, on infrared spectrogram, demonstrate the characteristic peak of hydroxyapatite, wave number is at 602 ± 5cm
-1With 560 ± 5cm
-1The reflection peak at place.
Described bioactivity glass can be obtained by sol-gel process, high-temperature fusion sintering process or Hydrothermal Preparation:
The concrete steps that described sol-gel process prepares bioactivity glass are: be catalyst with rare nitric acid, alcoholic solution with the raw material ethyl orthosilicate of glass ingredient correspondence, the alcoholic solution of triethyl phosphate, the lime nitrate alcoholic solution, the Chile saltpeter Ludox, the butyl titanate alcoholic solution is got material respectively, under stirring condition, add reaction vessel successively, after stirring 90min, obtain wet gel after rising to 40 ℃ of heavyization 24h-72h by room temperature, 60 ℃-100 ℃ are sieved behind the dry 12h-48h down again, and siftage is put into 600 ℃ of-750 ℃ of sintering 4h of Muffle furnace and obtained particle diameter less than the bioactive glass powder of 100 μ m;
The concrete steps that described high-temperature fusion sintering process prepares bioactivity glass are: raw material silicon oxide, calcium carbonate, sodium phosphate, sodium carbonate, the sodium titanate powder of glass ingredient correspondence are got material, put into after the ball mill wet grinding dry, put into corundum crucible, fusion in 1200 ℃-1450 ℃ in Muffle furnace then, shrend in distilled water behind the insulation 2h, shrend form ball mill pulverizing after the thing drying, sieving obtains particle diameter less than the bioactive glass powder of 100 μ m;
The concrete steps of described Hydrothermal Preparation bioactivity glass are: earlier raw material silicon oxide, calcium carbonate, sodium phosphate, sodium carbonate, the sodium titanate of glass ingredient correspondence are got material, be put in ball milling 5h-10h in the ball mill, on hydraulic press, be pressed into block or cylinder after the drying and screening, powder body after will suppressing then is put in the high-pressure hydrothermal reaction kettle, screens particle diameter less than the bioactive glass powder of 100 μ m behind 180 ℃ of-250 ℃ of hydrothermal treatment consists 24h-72h.
The above dual anti-dentin hypersensitiveness compositions can be unguentum, paste, gel, solution, membrane or powder.
Can also comprise in abrasivus, surfactant, sweeting agent, spice, thickening agent, adhesive, antiseptic and the wetting agent etc. one or more in the described dual anti-dentin hypersensitiveness compositions:
Described abrasivus can be one or more the mixture in calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminium hydroxide, the silicon oxide, is preferably one or more mixture of silicon oxide or silicon oxide and other, and accounting for composition weight percentage ratio is 10%-16%;
Described surfactant can be one or more the mixture in N-sodium lauroyl sarcosine, sodium lauryl sulphate and the dodecylbenzene sodium sulfonate, and accounting for composition weight percentage ratio is 1%-3%;
Described sweeting agent can be one or more the mixture in saccharin sodium, steviosin and the xylitol, and accounting for composition weight percentage ratio is 0.1%-1.5%;
Described spice can be and stays a kind of in orchid, Herba Menthae, Fructus Citri Limoniae, green tea and the Ilicis Purpureae, and accounting for composition weight percentage ratio is 0.5%-1.5%;
Described thickening agent can be one or both the mixture in silicon dioxide and the aluminium-magnesium silicate, and accounting for composition weight percentage ratio is 5%-10%;
Described adhesive can be one or more the mixture in carbomer, sodium carboxymethyl cellulose, guar gum and the carrageenan, is preferably carbomer or carbomer and one or more mixture wherein, and accounting for composition weight percentage ratio is 0.2%-0.4%;
Described antiseptic can be one or both the mixture in hydroxy benzoic acid sodium and the sodium sulfite, and accounting for composition weight percentage ratio is 0.05%-0.1%;
Described wetting agent can be one or more the mixture in glycerol, Polyethylene Glycol, sorbitol and the propylene glycol, and accounting for composition weight percentage ratio is 55%-70%.
The present invention also provides a kind of method for compositions for preparing dual anti-dentin hypersensitiveness, can may further comprise the steps:
1) takes by weighing raw material by prescription, under quick stirring condition, be pre-dispersed in abrasivus, bioactive glass powder, potassium salt, sweeting agent, thickening agent, adhesive, antiseptic, surfactant in the wetting agent respectively;
2) under vacuum, quick stirring condition, according to the definite sequence abrasivus that step 1) is scattered, bioactive glass powder, potassium salt, sweeting agent, thickening agent, adhesive, antiseptic, surfactant mix homogeneously, and stir fast;
3) add spice under the stirring condition at a slow speed, leave standstill, obtain dual dentin hypersensitiveness compositions.
Wherein, the quick mixing time described step 2) is 0.5h-1h; Time of repose in the described step 3) is 10min-2h, is preferably 0.5h.
The application of the above dual anti-dentin hypersensitiveness compositions in the preparation Related product also belongs to the present invention.Related product is: the pharmaceutical composition that is used for anti-dentin hypersensitiveness; The pharmaceutical composition that is used for prevention or treatment teeth corrosion, gingival hemorrhage; Or be used for cleaning one's teeth, the product of dental care or oral hygiene.
Adopt above scheme, the invention provides the dual anti-dentin hypersensitiveness compositions that a kind of main component comprises bioactivity glass and potassium salt, can be used for prevention and treatment (eliminate or alleviate) dentin hypersensitiveness, potassium salt discharges potassium ion fast pain relief (reducing the irritability of dental pulp nerve) on the one hand, bioactivity glass can replenish the dental structure mineral on the other hand, and form stable carbonated hydroxyapatite, but degree of depth sealing dentinal tubule (changing the permeability of dentinal tubule), curative effect improves greatly, fundamentally eliminate pain sense and anaphylaxis, reach the purpose for the treatment of both the principal and secondary aspects of a disease, because of titaniferous in the bioactivity glass composition, make the formed apatite layer of dental surface firmer wear-resisting again, resist daily stimulation better.
Below in conjunction with specific embodiment the present invention is described in further details.
Description of drawings
The infrared spectrum of the hydroxyapatite that Fig. 1 generates after with Tris solution soaking 48h for the titaniferous bioactivity glass
Fig. 2 is that the dentin hypersensitiveness position is without the SEM figure of the dentinal tubule of repairing
Fig. 3 uses the artificial saliva that is dispersed with the dual anti-dentin hypersensitiveness of the present invention compositions to soak Dentinal SEM figure after five days
Fig. 4 uses the artificial saliva that is dispersed with the dual anti-dentin hypersensitiveness of the present invention compositions to soak the SEM figure of the apatite layer that forms in dentin surface after five days
Fig. 5 is through the Dentinal tooth of the dual anti-dentin hypersensitiveness of the present invention compositions, repairs, imitates the dentin SEM figure of physical stimulation every day for 40 times with the laughable 5min of immersion, imitation chemical stimulation in continuous five days, toothbrush grooming
Fig. 6 is after the lactic acid demineralization, without the SEM figure of the enamel surface of repairing
Fig. 7 every day twice, each 5 minutes, uses a week adamantine SEM figure in back continuously for tooth after the demineralization being used the mastic simulation toothpaste be dispersed with the dual anti-dentin hypersensitiveness of the present invention compositions process of brushing teeth
The specific embodiment
The invention provides a kind of dual anti-dentin hypersensitiveness compositions, be to utilize the synergism of two kinds of desensitizeies, a kind of, more completely anti-dentin hypersensitiveness product more effective than single desensitizer is provided.
Dual anti-dentin hypersensitiveness provided by the present invention compositions, its effective ingredient are to account for the potassium salt of composition total weight 0.3%-12% and the titaniferous bioactivity glass of 0.5%-15%.Wherein:
One or more mixing in the potassium salt of provided potassium ion source of glycerol or water, disproportional restriction during mixing are provided for potassium nitrate, potassium chloride, potassium citrate, potassium oxalate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate and potassium bicarbonate etc. potassium salt; The raw material selection that potassium nitrate, potassium chloride, potassium citrate, potassium oxalate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate and potassium bicarbonate can obtain easily by reality, effect is suitable.
The titaniferous bioactivity glass is the graininess bioactivity glass, and particle diameter is less than 100 μ m.It is formed by weight percentage, comprises (by weight percentage):
This titaniferous bioactivity glass can be obtained by sol-gel process, high-temperature fusion sintering process or Hydrothermal Preparation by the proportioning raw materials of above-mentioned glass ingredient:
The concrete steps that sol-gel process prepares bioactivity glass are: be catalyst with rare nitric acid, alcoholic solution (the ethanol molal quantity is 2～7 times of ethyl orthosilicate molal quantity) with the raw material ethyl orthosilicate of glass ingredient correspondence, the alcoholic solution of triethyl phosphate (the ethanol molal quantity is the molal quantity that waits of triethyl phosphate), lime nitrate alcoholic solution (the ethanol molal quantity is 1.5～4.5 times of lime nitrate molal quantity), Chile saltpeter, magnesium nitrate, potassium nitrate, butyl titanate alcoholic solution (the ethanol molal quantity is 2～7 times of ethyl orthosilicate molal quantity) is got material by the weight ratio that glass ingredient calculates, the order of mentioning by described various raw materials under stirring condition adds in the reaction vessel successively, after stirring 90min, obtain wet gel after rising to 40 ℃ of heavyization 24h-72h by room temperature, sieve behind the dry 12h-48h down at 60 ℃-100 ℃, sieve (100 μ m are following) powder is down put into 600 ℃ of-750 ℃ of sintering 4h of Muffle furnace and is obtained particle diameter less than the bioactive glass powder of 100 μ m again;
The concrete steps that the high-temperature fusion sintering process prepares bioactivity glass are: with raw material silicon oxide, calcium carbonate, sodium phosphate, sodium carbonate, magnesium carbonate, potassium carbonate, the sodium titanate powder of glass ingredient correspondence, get material by the weight that glass ingredient calculates, put into after the ball mill wet grinding dry again, put into corundum crucible, fusion in 1200 ℃-1450 ℃ in Muffle furnace then, the insulation 2h after shrend in distilled water, after the shrend shaping thing drying again ball mill pulverizing, sieving obtains particle diameter less than the bioactive glass powder of 100 μ m;
The concrete steps of Hydrothermal Preparation bioactivity glass are: the first weight ratio that raw material silicon oxide, calcium carbonate, sodium phosphate, sodium carbonate, magnesium carbonate, potassium carbonate, the sodium titanate glass ingredient of glass ingredient correspondence are calculated is got material, be put in ball milling 5h-10h in the ball mill, drying and screening (200 order) back is pressed into block or cylinder on hydraulic press, powder body after will suppressing then is put in the high-pressure hydrothermal reaction kettle, selects for use particle diameter less than the bioactive glass powder of 100 μ m behind 180 ℃ of-250 ℃ of hydrothermal treatment consists 24h-72h.
After bioactivity glass and water or physiological solution are had an effect, can generate hydroxyapatite, on infrared spectrogram, demonstrate the characteristic peak of hydroxyapatite, wave number is at 602 ± 5cm
-1With 560 ± 5cm
-1The characteristic peak at place.
In the present composition, used the titaniferous bioactivity glass of special preparation, this titaniferous bioactivity glass can generate the hydroxyapatite that is deposited on dental surface with water and ptyaloreaction during use, and hydroxyapatite is more firm wear-resisting.
Among the present invention, dual anti-dentin hypersensitiveness compositions can work with the form of unguentum, paste, gel, solution, membrane or powder, and base material is corresponding conventional materials when multi-form, as glycerol, carrageenan, Polyethylene Glycol etc. wherein one or more.Can also comprise other additive in the dual anti-dentin hypersensitiveness compositions, as in abrasivus, surfactant, sweeting agent, spice, thickening agent, adhesive, antiseptic and the wetting agent etc. one or more.Abrasivus can be one or more the mixture in calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminium hydroxide, the silicon oxide, is preferably one or more mixture of silicon oxide or silicon oxide and other, and silica comprises is more than 50% during mixing; The raw material selection that calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminium hydroxide can obtain easily by reality, effect is suitable.It is 10%-16% that abrasivus accounts for composition weight percentage ratio.Surfactant can be one or more the mixture in N-sodium lauroyl sarcosine, sodium lauryl sulphate and the dodecylbenzene sodium sulfonate, disproportional restriction during mixing; The raw material selection that N-sodium lauroyl sarcosine, sodium lauryl sulphate and dodecylbenzene sodium sulfonate can obtain easily by reality, effect is suitable.Surfactant comprise composition weight percentage ratio is 1%-3%.Sweeting agent can be one or more the mixture in saccharin sodium, steviosin and the xylitol, disproportional restriction during mixing, and the raw material selection that can obtain easily by reality, effect is suitable.It is 0.1%-1.5% that sweeting agent accounts for composition weight percentage ratio.Spice can be and stays a kind of in orchid, Herba Menthae, Fructus Citri Limoniae, green tea and the Ilicis Purpureae, and accounting for composition weight percentage ratio is 0.5%-1.5%.Thickening agent can be one or both the mixture in silicon dioxide and the aluminium-magnesium silicate, disproportional restriction during mixing, and the raw material selection that can obtain easily by reality, effect is suitable.It is 5%-10% that thickening agent accounts for composition weight percentage ratio.Adhesive can be one or more the mixture in carbomer, sodium carboxymethyl cellulose, guar gum and the carrageenan, is preferably carbomer or carbomer and one or more mixture wherein, disproportional restriction during mixing; The raw material selection that sodium carboxymethyl cellulose, guar gum and carrageenan can obtain easily by reality, effect is suitable.It is 0.2%-0.4% that adhesive accounts for composition weight percentage ratio.Antiseptic can be one or both the mixture in hydroxy benzoic acid sodium and the sodium sulfite, disproportional restriction during mixing, and the raw material selection that can obtain easily by reality, effect is suitable.It is 0.05%-0.1% that antiseptic accounts for composition weight percentage ratio.Wetting agent can be one or more the mixture in glycerol, Polyethylene Glycol, sorbitol and the propylene glycol, disproportional restriction during mixing, and the raw material selection that can obtain easily by reality, effect is suitable.It is 55%-70% that wetting agent accounts for composition weight percentage ratio.
The mechanism of the prevention of dual anti-dentin hypersensitiveness of the present invention compositions and treatment (eliminate or alleviate) dentin hypersensitiveness is as follows:
1, potassium salt has irritability and the sensitivity that reduces the dental pulp nerve, anesthesia dental pulp nerve, lenitive effect;
2, bioactivity glass can react with water and saliva, produces the stable crystalline hydroxyapatite layer that is deposited in the dentinal tubule, sealing dentinal tubule, the permeability of change dentinal tubule; Has the titanium oxide that strengthens its material mechanical because containing in the bioactivity glass component again, make the modification that strengthened of the hydroxyapatite layer of new formation, and then tooth is strengthened, better resist daily stimulation, the present invention except with patent documentation CN101407373B in disclosed strontium can the reinforced bioactivity glass glass, also make its advantage with better wear resistance, corrosion stability, the more important thing is mix titanium bioactive glass lure the osteogenesis characteristic good;
3, two kinds of combination of components of potassium salt and titaniferous bioactivity glass can produce synergistic function, can play the effect of better and lasting anti-dentin hypersensitiveness than one-component.The present invention uses potassium salt in conjunction with playing the progressively bioactive materials of mineralising sealing process in dentin surface, can make analgesic effect better, and can significantly reduce the liquid stream in the tubule of stimulation pain.In the process of potassium salt relieving ease pain, can utilize bioactivity glass sealing dentinal tubule, induce the dentium nitor face to form, play the effect of reparation, fundamentally eliminate anaphylaxis.
The present invention also provides the dual anti-dentin hypersensitiveness of a kind of preparation method for compositions, can may further comprise the steps:
1) takes by weighing raw material by prescription, under quick stirring condition, be pre-dispersed in abrasivus, bioactive glass powder, potassium salt, sweeting agent, thickening agent, adhesive, antiseptic, surfactant in the wetting agent respectively;
2) under vacuum, quick stirring condition, according to the definite sequence abrasivus that step 1) is scattered, bioactive glass powder, potassium salt, sweeting agent, thickening agent, adhesive, antiseptic, surfactant mix homogeneously, and stir fast;
3) add spice under the stirring condition at a slow speed, leave standstill, obtain dual dentin hypersensitiveness compositions.
In above-mentioned dual anti-dentin hypersensitiveness preparation of compositions method, step 2) the quick mixing time in is 0.5h-1h.Time of repose in the step 3) is 10min-2h, is preferably 0.5h.
Described dual anti-dentin hypersensitiveness compositions is also belonging to protection scope of the present invention for the preparation of the application in the pharmaceutical composition of anti-dentin hypersensitiveness.
Described dual anti-dentin hypersensitiveness compositions is also belonging to protection scope of the present invention for the preparation of the application in the pharmaceutical composition of prevention or treatment teeth corrosion, gingival hemorrhage.
Described dual anti-dentin hypersensitiveness compositions for the preparation of clean one's teeth, application in the product of dental care or oral hygiene also belongs to protection scope of the present invention.
Embodiment is being to implement under the prerequisite with the technical solution of the present invention, has provided detailed embodiment and concrete operating process, and embodiment will help to understand the present invention, but protection scope of the present invention is not limited to following embodiment.
Method therefor is conventional method if no special instructions among the following embodiment.
The prescription of embodiment 1-5 dual anti-dentin hypersensitiveness compositions and comparative example is as shown in table 1:
The prescription of table 1 embodiment 1-5 dual anti-dentin hypersensitiveness compositions and comparative example
Bioactivity glass can obtain by aforementioned sol-gel process, high-temperature fusion sintering process or Hydrothermal Preparation, no longer repeats.
The dual anti-dentin hypersensitiveness of embodiment 1-5 paste compositions can prepare according to the following steps:
1) takes by weighing raw material by the percentage by weight in the table 1, under quick stirring condition, be pre-dispersed in abrasivus, bioactive glass powder, potassium salt, sweeting agent, thickening agent, adhesive, antiseptic, surfactant in the wetting agent respectively;
2) under vacuum, quick stirring condition, according to the definite sequence abrasivus that step 1) is scattered, bioactive glass powder, potassium salt, sweeting agent, thickening agent, adhesive, antiseptic, surfactant mix homogeneously, and stir 0.5h-1h fast;
3) add spice under the stirring condition at a slow speed, leave standstill 0.5h, obtain dual dentin hypersensitiveness compositions.
After testing, the bioactivity glass of embodiment 1-5 preparation is the graininess bioactivity glass, and particle diameter is less than 100 μ m.After bioactivity glass and water or physiological solution are had an effect, can generate hydroxyapatite, on the infrared spectrogram (see figure 1), demonstrate the characteristic peak of hydroxyapatite, wave number is at 602 ± 5cm
-1With 560 ± 5cm
-1The reflection peak at place.
The oral cavity safety of test example one, the dual anti-dentin hypersensitiveness of detection the present invention compositions
Detect the oral cavity safety of the dual anti-dentin hypersensitiveness compositions of embodiment 1-5 preparation, carry out repeatedly oral stimulation reaction test according to the method for stipulating among the GB/T16886.10 and test, concrete grammar is as follows:
The cricetulus auratus of select health for use, just growing up, the mastic that is made into embodiment 1-5 is directly as test sample.Before the test upset cricetulus auratus buccal with normal saline flushing after, check have no abnormal.Soak into test sample with cotton balls, record used volume, put into the buccal, both sides of animal.Should be no less than 5min time of contact.Remove cotton balls after the contact, use the normal saline flushing buccal, not setting-out of opposite side cheek pouch product in contrast.Give sample every day 2 times, the morning 1 time, afternoon 1 time, totally 7 days.Observe its medicine-feeding part in last to 24h behind the sample and have or not erythema and edema.And fill in the experimental observation log.Perusal cheek pouch behind the taking-up test ball, and (when repeatedly contacting) checks cheek pouch before each contact.Describe the general situation of animal cheek pouch, and by the standard score system that table 2 provides, judge that each observation period cheek pouch surface erythema of animal keeps the score.In this test, each embodiment is got 3 cricetulus auratuses, and its average mark of back calculating of keeping the score respectively, and the on average situation of keeping the score of embodiment 1-5 and comparative example 3 is listed in the table 3.
The reaction detection result is as shown in table 3 in the oral cavity, and on average keeping the score of embodiment 1-5 is starkly lower than the blank group as can be seen, shows that the oral cavity safety of the dual anti-dentin hypersensitiveness compositions that embodiment 1-5 prepares is better.
Table 2 oral cavity reaction normal score system
| Reaction | Standard is kept the score |
| No erythema | 0 |
| Utmost point slight erythema | 1 |
| Erythema is clear | 2 |
| Moderate erythema | 3 |
| Severe erythema (aubergine) to eschar forms | 4 |
The table 3 oral cavity reaction normal appraisal result of keeping the score
| Group | On average keep the score |
| Embodiment 1 | 0 |
| Embodiment 2 | 1 |
| Embodiment 3 | 0 |
| Embodiment 4 | 1 |
| Embodiment 5 | 0 |
| Comparative example 3 blanks | 2 |
Oral histology estimates: last is to 24h perusal cheek pouch behind the sample, painless execution suslik, the tissue sample of getting the representative position of cheek pouch is put into fixative and (is generally used 4% formalin, compound method is: with PBS or 0.9% sodium chloride injection by 1:9 directly dilution get final product) in carry out Histological evaluation at microscopically after fixing (10-20 that the consumption of fixative is generally tissue volume doubly, fixedly 1-2 days).
Oral histology's evaluation criterion is as shown in table 4, keep the score according to evaluation and can calculate the oral mucosa stimulation index, concrete grammar is: the microscopic evaluation of all animals the addition of keeping the score in the test group again divided by observing sum, draws test group on average keep the score (it is 16 that maximum is kept the score).Comprehensive perusal and the result of Histological evaluation, test group on average keep the score and deduct the blank group and on average keep the score and draw the oral mucosa stimulation index.
Equally, in this test, each embodiment is got three cricetulus auratuses, and calculates its oral mucosa stimulation index behind the integration respectively.
Oral mucosa stimulation index appraisal result is as shown in table 5, the oral mucosa stimulation index of embodiment 1-5 is starkly lower than the blank group as can be seen, shows with the dual anti-dentin hypersensitiveness of the paste among the embodiment 1-5 compositions Golden Hamster is repeatedly contacted almost nonirritant of oral cavity.
Table 4 oral histology microscope standard score system
Table 5 oral histology microscope appraisal result
| Group | Stimulation index | The extent of reaction |
| Embodiment 1 | 2 | Extremely light |
| Embodiment 2 | 1 | Extremely light |
| Embodiment 3 | 2 | Extremely light |
| Embodiment 4 | 1 | Extremely light |
| Embodiment 5 | 1 | Extremely light |
| Comparative example 3 blanks | 3 | Extremely light |
The tooth antiallergic effect of test example two, the dual anti-dentin hypersensitiveness of detection the present invention compositions
To embodiment 5, comparative example 1(single creature activity glass group), the single potassium salt group of comparative example 2() and comparative example 3(blank) four groups of samples carry out tooth antiallergic and detect, 80 people that suffer from dental hypersensitiveness are divided into four groups at random, every group of 20 people, all experimenters use the toothbrush of the same model of same manufacturer production.All experimenters use sample twice every day at least, smear the sensitizing range or use sample to brush teeth, and use for six weeks continuously.
Test method: 1. clinical examination, probe are visited to draw and are suffered from the odonthemodia position, the record sensitivity; To suffer from tooth and adjacent teeth is kept apart with lap, cold air vertically blows 1s apart from buccal surface 5mm, record sensitivity (being the pain rank).Repeat 2 times, if 2 degree varies cause, the degree of getting weighs; If 2 kinds of irritant reaction degree varies are caused, negate should the person of weight.2. sensitivity classification: Ishikawa is repaiied two evaluation criteria and is divided into 4 degree, and 3 degree can bring out insufferable pain for stimulating; 2 degree can bring out obvious pain for stimulating, but can stand; 1 degree is for stimulating the pain that can bring out slight or sense of discomfort arranged; 0 degree does not have pain for the cold-peace mechanical stimulus.The odonthemodia position that whole test takes same method assessment experimenter to fix, the experimenter records sensitivity after tooth is upset, 0 all base line assessments; Assessment in latter stage when the mid-stage assessment of 2 whens week and 6 weeks.3. efficacy assessment standard: produce effects for the number of degrees before and after the treatment poor 〉=2; Be 1 for number of degrees difference before and after the treatment effectively; Invalid is 0 for treating front and back number of degrees difference; Worsening to treating front and back number of degrees difference is negative.Effective percentage (%)=(produce effects+effectively) number/treatment sum * %.
Testing result is shown in table 6-table 8, and all experimenters (120 people) that finish test have recorded and assessed before the use sample in 0 thoughtful 6 weeks and sensitivity (the being the pain rank) rank after using.According to the record result, after using sample, the anti-dentin hypersensitiveness effect that the dual antiallergic sample of I group, II group single creature activity glass sample and the single potassium salt sample of III group can both be certain; Number of degrees difference is found before and after each group treatment of concrete analysis, use the dual antiallergic sample of I group to be better than other three groups, be that sensitivity (being the pain rank) descended significantly before and after the experimenter used the dual antiallergic sample of I group, and the decline time of occurrence is (beginning of first week) early, experimenter's pain perception that sensitivity (being the pain rank) descends is not no longer repeatedly (before using sample, the pain rank that 29 people are arranged among the experimenter is 3 degree, and 1 people's pain rank is 2 degree.Use sample after one week, its 25 philtrum 4 people's pain rank is reduced to 2 degree, and another people's pain rank is reduced to 1 degree by 2 degree.Use sample after 2 weeks, the pain rank is reduced to 4 philtrums of 2 degree during a week, has people's pain rank to continue to drop to 1 degree, and its excess-three people's pain rank still is classified as 2 degree, and initial pain rank is that 3 degree experimenters were having 7 people to reduce to 2 degree in second week again.All reduce until the 29 philtrum pain ranks of being tried 30 philtrum pain ranks, 3 degree the 6th week, wherein 16 people reduce to 0 degree, feels pain no longer, 10 people reduce to 1 degree, 3 people reduce to 2 degree, and the experimenter that raises again after the pain rank reduces is not found in observations in six weeks), sensitivity is not seen recovery, and (the use sample is after one week, other experimenter who reduces to 2 degree of pain level does not feel the rank of the pain of 3 degree again, the pain perception of 1 degree does not appear being superior in 1 people who reduces to 1 degree, continue to observe to the 6th week, the phenomenon that the pain rank is recovered does not all appear in 30 experimenters that all pain ranks reduce, and no longer recovers after namely the pain rank reduces.During as the 5th week, the pain rank is that 5 people's ranks of 3 degree are reduced to 2 degree around the, the pain rank is that the 6 people's ranks that have of 2 degree are reduced to 1 degree around the, the pain rank is that 13 people of 1 degree have 5 people's pain ranks to reduce to 1 degree around the, around the to the 5th Monday Zhou Zhezhong pain rank have 1 people to keep 2 degree, have 8 people to keep 1 degree, 5 people are 0 degree always, the pain rank do not occur and reduce the experimenter that the back is raising; Its existing 5 people's pain ranks around the are reduced to 0 degree, do not occur pain perception yet until the 6th this five people of week, show the antiallergic longer duration, effect stability; II group experimenter is not because the sample that uses contains potassium salt, and the reparation damaged tooth of bioactivity glass needs certain hour, so experimenter's sensitivity downward trend is relatively poor than the I group, fall time, effect was also more stable than I group evening; The sample that the III group is used only contains potassium salt, use the back just can reduction of patient pain, so experimenter's sensitivity descends and I group no difference of science of statistics, but potassium salt alleviating pain acting duration is shorter, and damaged tooth still exposes dentinal tubule, the easy irriate of dental nerve, so part experimenter's sensitivity is recovered former rank, pain perception repeatedly, namely the respite effect is better, but the effect instability; Using sample after 6 weeks, each organizes antiallergic effect certain enhancing; IV group blank sample does not have tangible anti-dentin hypersensitiveness effect.Table 7,8 add up its effective percentage according to the difference of sensitivity before and after the treatment, the dual antiallergic sample of I group effective percentage after using for two weeks surpasses 50%, after six weeks, effective percentage is up to 86.7%, antiallergic effect obviously is better than the sample sets of single potassium salt and single creature activity glass, two kinds of compositionss are used because potassium salt alleviating pain rapidly, instant effect, bioactivity glass is in the lenitive while of potassium salt, reparation damaged tooth position slowly, when the potassium salt DeGrain or after disappearing, because damaged part is repaired by bioactivity glass, no longer recover after patient's pain rank is reduced, namely the patient is when the pain rank slowly reduces, and the damaged tooth position has also obtained reparation, when meeting environmental stimuli again, can not feel pain again, have the synergistic function of antiallergic effect instant effect and antiallergic longer duration, and in the test in six weeks, not have to find the side effect relevant with test products and sample to the side effect of oral soft tissue.
Table 6 experimenter sensitivity rank
The antiallergic curative effect of four groups of samples of table 7
The antiallergic curative effect statistics of four groups of samples of table 8
The tooth repairing effect of test example three, the dual anti-dentin hypersensitiveness of the present invention compositions
1, to the repairing effect of dentin hypersensitiveness position without the dentinal tubule of repairing
Test method is:
(1) people's tooth sample preparations: the sample tooth is indulged the standard laid down by the ministries or commissions of the Central Government originally with cutting machine with tooth cutting adult tooth through removing adhering tissue, sterilization and ultrasonic cleaning, and selecting the flawless glaze is the trial zone, 600# sand paper polishes, and is coated with nial polish outside the trial zone;
(2) get 20 of the Dentinal vertical portion of exposure tooth specimen, the citric acid acid etching dentin 1min with 50% pushes away distilled water flushing tooth specimen 1min with 50ml again, dries standby then;
(3) at random 12 tooth specimen are divided into three groups of A, B, C, 4 every group, the A group is not handled and is observed the dentin hypersensitiveness position; The B group is soaked in the artificial saliva that is dispersed with 1cm toothpaste sample (the dual anti-dentin hypersensitiveness of the present invention compositionss of embodiment 5 preparations), and every 12h changes soak one time, continues 5 days, scanning electron microscopic observation; The C group is soaked in the artificial saliva that is dispersed with 1cm toothpaste sample (the dual anti-dentin hypersensitiveness of the present invention compositionss of embodiment 5 preparations) equally, soak 5min simulation chemical stimulation every 12h with coca cola beverage, toothbrush is brushed teeth 20 times with the analog physical mechanical stimulus, so repeatedly, continue 5 days, scanning electron microscopic observation.
The dentin hypersensitiveness position without the SEM picture of the dentinal tubule of repairing as shown in Figure 2; The artificial saliva that use is dispersed with the dual anti-dentin hypersensitiveness of the present invention compositions (embodiment 5) is soaked after five days Dentinal SEM picture as shown in Figure 3, and dentinal tubule is fully stopped up as can be seen; The SEM figure that the apatite layer that forms in dentin surface after five days is soaked in the artificial saliva that use is dispersed with the dual anti-dentin hypersensitiveness of the present invention compositions as shown in Figure 4, as can be seen, apatite layer thickness reaches 5 μ m; Through the Dentinal tooth of the dual anti-dentin hypersensitiveness of the present invention compositions, repairs, use every day the dentin SEM of the laughable 5min of immersion, imitation chemical stimulation in continuous five days, 20 imitations of toothbrush grooming physical stimulation to scheme as shown in Figure 5, as can be seen, dentinal tubule is still fully stopped up.
2, to after the lactic acid demineralization, without the adamantine repairing effect of repairing
Test method is:
(1) enamel sample preparations: the sample tooth is indulged the standard laid down by the ministries or commissions of the Central Government originally with cutting machine with tooth cutting adult tooth through removing adhering tissue, sterilization and ultrasonic cleaning, and selecting the flawless glaze is the trial zone, 600# sand paper polishes, and is coated with nial polish outside the trial zone;
(2) artificial dental caries glaze preparation: have adamantine tooth specimen with 8 and be put in and soak 12h in the lactic acid demineralization liquid and prepare artificial dental caries glaze, clean the surface sweeping electron microscopic observation then with purified water;
(3) the simulation tooth is used: get 4 in artificial dental caries glaze at random and be soaked in the artificial saliva, sooner or later taking out the back every day uses toothpaste sample (the dual anti-dentin hypersensitiveness of the present invention compositionss of embodiment 5 preparations) 1cm on toothbrush, the tooth 2min that brushes teeth gets wet, then tooth is added the 50ml purified water to conical flask, be put in jolting 3min in 37 ℃ of thermostatic water bath, be dipped in again in the artificial saliva, so repeatedly after the purified water flushing, remineralization is after one week, scanning electron microscopic observation.
After the lactic acid demineralization, without the SEM picture of the enamel surface of repairing as shown in Figure 6; Tooth after the demineralization is used the mastic simulation toothpaste be dispersed with the dual anti-dentin hypersensitiveness of the present invention compositions process of brushing teeth, use the adamantine SEM picture in a week back continuously as shown in Figure 7, as can be seen, enamel surface forms apatite layer.
Relatively sum up and to draw according to SEM figure; after the dual anti-dentin hypersensitiveness of the damaged tooth process the present invention compositions-treated; dentinal tubule is blocked; and formed new enamel; behind daily chemistry, physical stimulation, still has thicker apatite layer; illustrate that formed dentium nitor face is wear-resisting, corrosion resisting property is good, not only can effectively treat dentin hypersensitiveness's reaction, and make tooth obtain reinforcement.
What this description of test was mixed titanium bioactive glass lures the osteogenesis characteristic good.Here, bioactivity glass plays and mainly lures the osteogenesis effect, and titanium is doped chemical, is luring osteogenesis to play assosting effect on, and it mainly improves is that the osseous tissue repaired of bioactivity glass is firm wear-resisting, and does not influence biocompatibility; And the use of titanium is low than the cost of strontium, good stability.
Claims (10)
1. dual anti-dentin hypersensitiveness compositions, its effective ingredient is to account for the potassium salt of composition weight percentage ratio 0.3%-12% and the titaniferous bioactivity glass of 0.5%-15%.
2. compositions according to claim 1 is characterized in that: one or more in the potassium salt of provided potassium ion source of glycerol or water are provided for potassium nitrate, potassium chloride, potassium citrate, potassium oxalate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate and potassium bicarbonate etc. described potassium salt.
3. compositions according to claim 1 and 2, it is characterized in that: described titaniferous bioactivity glass is the graininess bioactivity glass, particle diameter in weight ratio, wherein contains following glass ingredient less than 100 μ m:
4. according to claim 1 or 2 or 3 described compositionss, it is characterized in that: after described bioactivity glass and water or physiological solution are had an effect, can generate hydroxyapatite, on infrared spectrogram, demonstrate the characteristic peak of hydroxyapatite, wave number is at 602 ± 5cm
-1With 560 ± 5cm
-1The reflection peak at place.
5. according to the arbitrary described compositions of claim 1 to 4, it is characterized in that: described bioactivity glass can be obtained by sol-gel process, high-temperature fusion sintering process or Hydrothermal Preparation:
The concrete steps that described sol-gel process prepares bioactivity glass are: be catalyst with rare nitric acid, alcoholic solution with the raw material ethyl orthosilicate of glass ingredient correspondence, the alcoholic solution of triethyl phosphate, the lime nitrate alcoholic solution, the Chile saltpeter Ludox, the butyl titanate alcoholic solution is got material respectively, under stirring condition, add reaction vessel successively, after stirring 90min, obtain wet gel after rising to 40 ℃ of heavyization 24h-72h by room temperature, 60 ℃-100 ℃ are sieved behind the dry 12h-48h down again, and siftage is put into 600 ℃ of-750 ℃ of sintering 4h of Muffle furnace and obtained particle diameter less than the bioactive glass powder of 100 μ m;
The concrete steps that described high-temperature fusion sintering process prepares bioactivity glass are: raw material silicon oxide, calcium carbonate, sodium phosphate, sodium carbonate, the sodium titanate powder of glass ingredient correspondence are got material, put into after the ball mill wet grinding dry, put into corundum crucible, fusion in 1200 ℃-1450 ℃ in Muffle furnace then, shrend in distilled water behind the insulation 2h, shrend form ball mill pulverizing after the thing drying, sieving obtains particle diameter less than the bioactive glass powder of 100 μ m;
The concrete steps of described Hydrothermal Preparation bioactivity glass are: earlier raw material silicon oxide, calcium carbonate, sodium phosphate, sodium carbonate, the sodium titanate of glass ingredient correspondence are got material, be put in ball milling 5h-10h in the ball mill, on hydraulic press, be pressed into block or cylinder after the drying and screening, powder body after will suppressing then is put in the high-pressure hydrothermal reaction kettle, screens particle diameter less than the bioactive glass powder of 100 μ m behind 180 ℃ of-250 ℃ of hydrothermal treatment consists 24h-72h.
6. according to each described compositions of claim 1-7, it is characterized in that: described dual anti-dentin hypersensitiveness compositions can be unguentum, paste, gel, solution, membrane or powder.
7. compositions according to claim 6 is characterized in that: can also comprise in abrasivus, surfactant, sweeting agent, spice, thickening agent, adhesive, antiseptic and the wetting agent etc. one or more in the described dual anti-dentin hypersensitiveness compositions:
Described abrasivus can be one or more the mixture in calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminium hydroxide, the silicon oxide, is preferably one or more mixture of silicon oxide or silicon oxide and other, and accounting for composition weight percentage ratio is 10%-16%;
Described surfactant can be one or more the mixture in N-sodium lauroyl sarcosine, sodium lauryl sulphate and the dodecylbenzene sodium sulfonate, and accounting for composition weight percentage ratio is 1%-3%;
Described sweeting agent can be one or more the mixture in saccharin sodium, steviosin and the xylitol, and accounting for composition weight percentage ratio is 0.1%-1.5%;
Described spice can be and stays a kind of in orchid, Herba Menthae, Fructus Citri Limoniae, green tea and the Ilicis Purpureae, and accounting for composition weight percentage ratio is 0.5%-1.5%;
Described thickening agent can be one or both the mixture in silicon dioxide and the aluminium-magnesium silicate, and accounting for composition weight percentage ratio is 5%-10%;
Described adhesive can be one or more the mixture in carbomer, sodium carboxymethyl cellulose, guar gum and the carrageenan, is preferably carbomer or carbomer and one or more mixture wherein, and accounting for composition weight percentage ratio is 0.2%-0.4%;
Described antiseptic can be one or both the mixture in hydroxy benzoic acid sodium and the sodium sulfite, and accounting for composition weight percentage ratio is 0.05%-0.1%;
Described wetting agent can be one or more the mixture in glycerol, Polyethylene Glycol, sorbitol and the propylene glycol, and accounting for composition weight percentage ratio is 55%-70%.
8. one kind prepares the described dual anti-dentin hypersensitiveness of claim 7 method for compositions, may further comprise the steps:
1) takes by weighing raw material by prescription, under quick stirring condition, be pre-dispersed in abrasivus, bioactive glass powder, potassium salt, sweeting agent, thickening agent, adhesive, antiseptic, surfactant in the wetting agent respectively;
2) under vacuum, quick stirring condition, according to the definite sequence abrasivus that step 1) is scattered, bioactive glass powder, potassium salt, sweeting agent, thickening agent, adhesive, antiseptic, surfactant mix homogeneously, and stir fast;
3) add spice under the stirring condition at a slow speed, leave standstill, obtain dual dentin hypersensitiveness compositions.
9. preparation method according to claim 8, it is characterized in that: the quick mixing time described step 2) is 0.5h-1h; Time of repose in the described step 3) is 10min-2h, is preferably 0.5h.
10. the application of each described dual anti-dentin hypersensitiveness compositions of claim 1-7 in the preparation Related product; Related product is:
The pharmaceutical composition that is used for anti-dentin hypersensitiveness;
The pharmaceutical composition that is used for prevention or treatment teeth corrosion, gingival hemorrhage; Or
Be used for cleaning one's teeth, the product of dental care or oral hygiene.
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