CN108653398A - One kind being exclusively used in hypo-allergenic combination medicament during plant tooth - Google Patents
One kind being exclusively used in hypo-allergenic combination medicament during plant tooth Download PDFInfo
- Publication number
- CN108653398A CN108653398A CN201810791173.8A CN201810791173A CN108653398A CN 108653398 A CN108653398 A CN 108653398A CN 201810791173 A CN201810791173 A CN 201810791173A CN 108653398 A CN108653398 A CN 108653398A
- Authority
- CN
- China
- Prior art keywords
- hypo
- parts
- exclusively used
- allergenic
- combination medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
The invention discloses one kind be exclusively used in plant tooth during hypo-allergenic combination medicament, it is described be exclusively used in plant tooth during hypo-allergenic combination medicament include following components：Anti-allergic agent, Chinese medical extract, potassium citrate, antierythrite, sorbierite, N sodium lauroyl sarcosines, carbomer, water.The hypo-allergenic combination medicament during being exclusively used in planting tooth of the present invention, it has no toxic side effect, containing there are many Chinese herbal medicines, addition has antibacterial, hemostasia effect bio-vitric, meet traditional Chinese medicine and pharmacy and modern medical theory, can effectively antibacterial, hemostasis, hypo-allergenic, stablize surface of a wound surrounding tissue, wound healing and gingiva tissue regeneration, can be used for planting hemostasis during tooth, anti-inflammatory and hypo-allergenic.
Description
Technical field
The present invention relates to one kind be exclusively used in plant tooth during hypo-allergenic combination medicament.
Background technology
Tooth is the hard but flexible calcic tissue of mechanical bearing enamel.It is every to lead to dental surface
The integrality of enamel by destroy, the various odontopathies to make dentine expose, such as wear away (often stinging hard object), wound and draw
The odontoclasis risen, brush teeth for a long time improper caused neck portion wedge-shaped defect, saprodontia and periodontal atrophy lead to Root exposnre etc., all
Dental hypersensitiveness can be caused.Dentinal tubule is filled with fluid, when tooth center is externally exposed in environment, is encountering gas
When stream, haptic type stimulation or caloric stimulation, Intradental nerve is stimulated, and leads to the pain sensation.
It is mostly toothpaste, mouthwash to improve the product of odonthemodia at present, lacks one kind in the market and is exclusively used in preventing during plant tooth
Allergy medicament.It generally utilizes fluoride by being acted on the dentine of tooth in hypo-allergenic product, one can be formed in dental surface
The hard fluor-apatite of layer, to improve the hardness of enamel.It can make the permeability of dental tissue using strontium chloride, potassium nitrate
It significantly reduces, reduces sensibility of the gum edge periodontium to various stimulations.Using gel or colloid compound can mechanicalness close
The nozzle for matching dential canaliculi, can play anti-allergic effects in a short time.Bioactivity glass is since 1971 by the U.S.
After professor Hench has found, people is caused widely to pay close attention to.One side bioactivity glass has the work of hemostasis, antibacterial, anti-inflammatory
With.On the other hand, compared with traditional biological activity glass, mesopore bioactive glass shows better bone remoulding ability and life
Object compatibility.Mesoporous bioglass has mesoporous phase (2-50nm), larger specific surface area and Kong Rong, and abundant surface silicon hydroxyl
Base can then provide more active site, therefore can reach higher drug loading.Bioactivity glass is in toothpaste
In have a large amount of example application, have good application prospect in planting tooth.Chinese medicine is often conceived to whole adjusting and makees
With emphasis part is contacted with whole body, payes attention to the disease-resistant potential for playing human body.Its therapy of " strengthening the body resistance to consolidate the constitution ", undoubtedly carries
The imperial sick ability of height, improves the important means of body's immunity, in long-term clinical process, has been got over traditional Chinese medicine is hypo-allergenic
More to show its advantage.Therefore how Chinese medicine treatment means and Porous bioglass material are combined applied to plant tooth by research
The hypo-allergenic treatment of patient has a good application prospect in the process.
Invention content
The present invention provides one kind and being exclusively used in hypo-allergenic combination medicament during plant tooth.The present invention adopts the following technical scheme that：
One kind being exclusively used in hypo-allergenic combination medicament during plant tooth, including following components：
Anti-allergic agent, Chinese medical extract, potassium citrate, antierythrite, sorbierite, N- sodium lauroyl sarcosines, carbomer,
Water.
One kind being exclusively used in hypo-allergenic combination medicament during plant tooth, including following components in parts by weight：
0.8-1.5 parts of anti-allergic agents, 0.1-0.5 parts of Chinese medical extracts, 0.05-0.15 parts of potassium citrates, 0.2-0.6 parts it is red
Moss sugar alcohol, 2-8 part sorbierite, 0.06-0.3 parts of N- sodium lauroyl sarcosines, 0.5-3.5 parts of carbomers, 90-100 parts of water.It is special
The preparation method of hypo-allergenic combination medicament is as follows during planting tooth：Chinese medical extract is added to the water, in 30-35 DEG C, rotating speed
It is stirred 25-50 minutes for 200-500r/min, anti-allergic agent, potassium citrate, antierythrite, sorbierite, N- lauroyl fleshes is added
Propylhomoserin sodium, Acritamer 940 continue to stir 40-60 minute in above-mentioned condition, obtain being exclusively used in hypo-allergenic combination medicine during plant tooth
Agent.
One kind being exclusively used in hypo-allergenic combination medicament during plant tooth, including following components in parts by weight：
0.8-1.5 parts of anti-allergic agents, 0.1-0.5 parts of Chinese medical extracts, 0.3-1 parts of bio-vitrics, 0.05-0.15 portions of lemons
Sour potassium, 0.2-0.6 part antierythrite, 2-8 parts of sorbierites, 0.06-0.3 parts of N- sodium lauroyl sarcosines, 0.5-3.5 parts of card waves
Nurse, 90-100 part water.Be exclusively used in plant tooth during hypo-allergenic combination medicament preparation method it is as follows：Water is added in Chinese medical extract
In, it is that 200-500r/min is stirred 25-50 minutes in 30-35 DEG C, rotating speed, bio-vitric is added, continues to stir in above-mentioned condition
25-50 minutes, anti-allergic agent, potassium citrate, antierythrite, sorbierite, N- sodium lauroyl sarcosines, Acritamer 940 is added, after
Continue and stirred 40-60 minute in above-mentioned condition, obtains being exclusively used in hypo-allergenic combination medicament during plant tooth.
According to any of the above item be exclusively used in plant tooth during hypo-allergenic combination medicament, anti-allergic agent be strontium chloride,
One kind in strontium acetate.
Hypo-allergenic combination medicament during being exclusively used in planting tooth according to any of the above item, the carbomer is carbomer
940。
Hypo-allergenic combination medicament during being exclusively used in planting tooth according to any of the above item, the system of the Chinese medical extract
Preparation Method is as follows：By Fructus Forsythiae, big goat's horn wooden dipper, Radix Glycyrrhizae, asarum, it is windproof in mass ratio be 1:(1-2):(2-4):(1-2):(1-3)
It is crushed after mixing, crosses 10-50 mesh sieve, obtain herb powder, 20-35g herb powders is taken to be added in 100-200mL water, be added
0.01-0.05g mixed enzymes are uniformly mixed, are warming up to 35-37 DEG C, and 28-32h is kept the temperature at 35-37 DEG C, is warming up to 95-100 DEG C,
95-100 DEG C keeps the temperature 3-5 minutes, is cooled to 28-32 DEG C, crosses 100-300 mesh sieve, obtains first-time filtrate and a filter cake, will be primary
Filter cake is added in the ethanol water that 80-120mL volume fractions are 60-75%, 65-75 DEG C is warming up to, in 65-75 DEG C, rotating speed
Stirred 1-4 hour for 200-500r/min, cross 100-300 mesh sieve, obtain secondary filtrate and secondary filter cake, merge first-time filtrate with
Secondary filtrate obtain mixing filtrate, will mixing filtrate be concentrated into the 1/30~1/10 of proper mass, by concentrate 35-45 DEG C,
0.01-0.03MPa conditions are dried 4-8 hours, and Chinese medical extract is obtained, and the mixed enzyme is cellulase, pectase, neutral egg
White enzyme is (1-3) in mass ratio:1:The mixture of (1-2).It is described by mix filtrate be concentrated into proper mass 1/30~1/10 tool
Body is that will to mix filtrate in 45-55 DEG C, 0.02-0.05MPa, rotating speed be that 10-50r/min is concentrated into the 1/30~1/ of proper mass
10.The Chinese medicine that the present invention uses has antibacterial, anti-inflammatory, hemostasis, analgesia, heat-clearing according to theory of traditional Chinese medical science reasonable compatibility, extract
Effect.
The preparation method of the bio-vitric preferably comprises following step：(1) template agent is prepared：1-2g celluloses are spread out
Biology, 0.05-0.15g N, N '-methylene-bisacrylamides are dissolved in 250-350g water, in 25-30 DEG C, rotating speed 100-
300r/min is stirred 30-60 minutes, and 1-3g tert-butyl acrylates are added, and is warming up to 35-40 DEG C, and 0.03-0.06g is added and causes
Agent stirs 1-3 hours in 35-40 DEG C, the condition that rotating speed is 200-500 revs/min, is subsequently cooled to 25-28 DEG C, use is a concentration of
The sodium hydrate aqueous solution of 0.1-0.5mol/L adjusts pH to 8-9, in 25-28 DEG C, the condition that rotating speed is 300-500 revs/min
Then stirring 0.5-1.5 hours is centrifuged 10-30 minutes with 8000-12000 revs/min of rotating speed, takes centrifugation gained sediment,
Drying 4-8 hours in 40-45 DEG C of drying box are placed in, template agent is obtained；(2) by 2-3mg template agents, 200-300mL water, 200-
300mL ethyl alcohol is heated to 38-42 DEG C after mixing, and 0.5-1g cetyl trimethylammonium bromides, 8-12mL mass point is added
Number is the ammonium hydroxide of 25%-28%, is that 200-500r/min is stirred 10-40 minutes in 38-42 DEG C, rotating speed, obtains mixture, take 5-
10g tetraethyl orthosilicates, 0.4-0.8g triethyl phosphates are dissolved in 250-350mL absolute ethyl alcohols, are then added to above-mentioned mixture
In, it is that 200-500r/min is stirred 100-150 minutes in 38-42 DEG C, rotating speed, 3-4g calcium chloride is added, continues in above-mentioned condition
36-52h is stirred, is then centrifuged 10-30 minutes with 5000-10000r/min, after centrifugal sediment is washed with 400-600g ethyl alcohol
It is 18-26 hours dry at 50-70 DEG C, it is then placed in Muffle furnace, 800-900 DEG C is warming up to 8-12 DEG C/min of rate,
800-900 DEG C of heat preservation 1.5-2.5h, natural cooling obtain bio-vitric.Initiator described in step (1) is potassium peroxydisulfate.Step
Suddenly cellulose derivative described in (1) is hydroxypropyl cellulose and/or hydroxyethyl cellulose.Cellulose derivative is further preferred
For the mixture of hydroxypropyl cellulose and hydroxyethyl cellulose, the mass ratio of the hydroxypropyl cellulose and hydroxyethyl cellulose is
(1-3)：(1-3), the type for adjusting cellulose derivative prepares the template of different structures with proportioning, final to influence product life
The grain size and pore structure of object glass.The bio-vitric that the present invention uses has larger specific surface area, grain size small.On the one hand, raw
Object glass can block sensitive conduit, inhibit sensitive teeth and improve or mitigate pain by sealing dentinal tubule.It is another
Aspect, bio-vitric have the function of hemostasis, antibacterial, anti-inflammatory.In addition, bio-vitric pore structure can preferably slow releasing pharmaceutical at
Point, achieve the effect that long term in tooth and gum.
The hypo-allergenic combination medicament during being exclusively used in planting tooth of the present invention, has no toxic side effect, containing there are many Chinese herbal medicine and tools
There is antibacterial, hemostasia effect bio-vitric, meets traditional Chinese medicine and pharmacy and modern medical theory, it can effectively antibacterial, hemostasis, anti-mistake
It is quick, stablize surface of a wound surrounding tissue, wound healing and gingiva tissue regeneration, can be used for planting hemostasis during tooth, anti-inflammatory and
It is hypo-allergenic
Specific implementation mode
Primary raw material used is as follows in following embodiments：
Fructus Forsythiae, the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.With heat-clearing
The effect of removing toxic substances, dispersing swelling and dissipating binds.
Big goat's horn wooden dipper, big goat's horn wooden dipper Cynanchum inamoenum (Maxim.) Lose.'s of Asclepiadaceae Cynanchum plant
Dry root.Has effects that clearing heat and cooling blood, relieving restlessness of bringing down a fever.
Radix Glycyrrhizae is the dry root of legume swollen fruit Radix Glycyrrhiza inflata Bat..With invigorating the spleen and benefiting qi,
It is clearing heat and detoxicating, the effect of expelling phlegm and arresting coughing, relieving spasm to stop pain.
Asarum is aristolochiaceae plant Herba Asari Asarum heterotropoides Fr.Schmidt
The drying herb of var.mandshuricum (Maxim.) Kitag..With expelling wind and clearing away cold, sensible analgesic, the work(of warming lung and resolving fluid
Effect.
It is windproof, it is the drying of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk.
Root.With the effect of inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.
Strontium acetate, No. CAS：543-94-2.
Hydroxypropyl cellulose, No. CAS：9004-64-2, M.W.：100000.It buys from Shanghai Aladdin biochemical technology share
Co., Ltd, product identification H113415.
Hydroxyethyl cellulose, No. CAS：9004-62-0,25 DEG C of viscosity (2% aqueous solution)：3400~5000mpa.s.Specifically
It buys from Shanghai Aladdin biochemical technology limited liability company, product identification H104788.
Tert-butyl acrylate, No. CAS：1663-39-4.
Calcium chloride, No. CAS：10043-52-4.
Potassium citrate, No. CAS：866-84-2.
Sorbierite, No. CAS：50-70-4.
Acritamer 940, U.S.'s Lu Borun boards.
Mass fraction is the ammonium hydroxide of 25%-28%, and purchase is compiled from Shanghai Aladdin biochemical technology limited liability company, product
Number A112077.
Cellulase, No. CAS：9012-54-8.The cellulase used in the embodiment of the present invention is to use trichoderma reesei
(Classification system：Trichodermareesei high efficiency cellulose system made of) being refined through processes such as liquid deep layer fermenting, ultrafiltration
Agent, the cellulase of specifically used model full constituent type 7000, enzyme activity：7000u/g, purchased from Ningxia, Xia Sheng industry group has
Limit company.
Pectase, 10,000 u/g of enzyme activity are purchased from Ningxia Sunson Industrial Group Co., Ltd., model SAC-015.
Neutral proteinase, No. CAS：9068-59-1.Enzyme activity：50u/mg.It buys from Shanghai Aladdin biochemical technology share
Co., Ltd, product identification：D195752.
It is further illustrated the present invention below by the mode of embodiment.
Embodiment 1
One kind being exclusively used in hypo-allergenic combination medicament during plant tooth, including following components in parts by weight：
1 part of anti-allergic agent, 0.3 part of Chinese medical extract, 0.1 part of potassium citrate, 0.3 part of antierythrite, 5 parts of sorbierites, 0.1
Part N- sodium lauroyl sarcosines, 3 parts of Acritamer 940s, 93 parts of water.The anti-allergic agent strontium acetate.
The preparation method of the Chinese medical extract is as follows：By Fructus Forsythiae, big goat's horn wooden dipper, Radix Glycyrrhizae, asarum, windproof it is in mass ratio
1:1:3:2:It is crushed after 1 mixing, crosses 30 mesh sieve, obtain herb powder, 32g herb powders is taken to be added in 150mL water, be added
0.02g mixed enzymes are uniformly mixed, are warming up to 36 DEG C, and 30h is kept the temperature at 36 DEG C, 98 DEG C is warming up to, 3 minutes is kept the temperature at 98 DEG C, cooling
It to 30 DEG C, sieves with 100 mesh sieve, obtains first-time filtrate and a filter cake, the second that 100mL volume fractions are 65% is added in a filter cake
In alcohol solution, be warming up to 70 DEG C, 70 DEG C, rotating speed be 300r/min stir 3 hours, sieve with 100 mesh sieve, obtain secondary filtrate and
Secondary filter cake, merges first-time filtrate and secondary filtrate obtains mixing filtrate, is in 50 DEG C, 0.04MPa, rotating speed by mixing filtrate
30r/min is concentrated into the 1/20 of proper mass, and concentrate is dried 6 hours in 40 DEG C, 0.01MPa conditions, obtains Chinese medical extract,
The mixed enzyme is that cellulase, pectase, neutral proteinase are 2 in mass ratio:1:1 mixture.
Be exclusively used in plant tooth during hypo-allergenic combination medicament preparation method it is as follows：Chinese medical extract is added to the water,
35 DEG C, rotating speed be 300r/min stir 30 minutes, be added anti-allergic agent, potassium citrate, antierythrite, sorbierite, N- lauroyl
Sodium sarcosinate, Acritamer 940 continue to stir 50 minutes in above-mentioned condition, obtain being exclusively used in planting hypo-allergenic combination medicine during tooth
Agent.
Embodiment 2
One kind being exclusively used in hypo-allergenic combination medicament during plant tooth, including following components in parts by weight：
1 part of anti-allergic agent, 0.3 part of Chinese medical extract, 0.5 part of bio-vitric, 0.1 part of potassium citrate, 0.3 part of erythrose
Alcohol, 5 parts of sorbierites, 0.1 part of N- sodium lauroyl sarcosine, 3 parts of Acritamer 940s, 93 parts of water.The anti-allergic agent strontium acetate.Institute
The preparation method for stating Chinese medical extract is same as Example 1.
The preparation method of the bio-vitric is as follows：(1) template agent is prepared：By 1.2g cellulose derivatives, 0.1g N,
N '-methylene-bisacrylamides are dissolved in 300g water, are that 200r/min is stirred 40 minutes in 25 DEG C, rotating speed, 1.5g propylene is added
Tert-butyl acrylate is warming up to 35 DEG C, and 0.04g potassium peroxydisulfates are added, and is stirred 2 hours in 35 DEG C, the condition that rotating speed is 300 revs/min,
25 DEG C are subsequently cooled to, pH to 8.5 is adjusted with the sodium hydrate aqueous solution of a concentration of 0.2mol/L, in 25 DEG C, rotating speed 300
Rev/min condition stir 1 hour, then centrifuged 20 minutes with 10000 revs/min of rotating speed, take centrifugation gained sediment, set
It is 6 hours dry in 40 DEG C of drying box, obtain template agent；(2) 2.5mg template agents, 250mL water, 250mL ethyl alcohol are mixed equal
It is heated to 40 DEG C after even, 0.7g cetyl trimethylammonium bromides are added, the ammonium hydroxide that 10mL mass fractions are 25%-28%,
40 DEG C, rotating speed be 300r/min stir 20 minutes, obtain mixture, 8g tetraethyl orthosilicates, 0.65g triethyl phosphates taken to be dissolved in
It in 300mL absolute ethyl alcohols, is then added in above-mentioned mixture, is that 300r/min is stirred 120 minutes in 40 DEG C, rotating speed, is added
3.5g calcium chloride is continued to stir 48h in above-mentioned condition, then be centrifuged 20 minutes with 8000r/min, centrifugal sediment 500g second
It is 24 hours dry at 60 DEG C after alcohol washing, it is then placed in Muffle furnace, 850 DEG C is warming up to 10 DEG C/min of rates, at 850 DEG C
2h is kept the temperature, natural cooling obtains bio-vitric.The cellulose derivative is the mixed of hydroxypropyl cellulose and hydroxyethyl cellulose
The mass ratio of conjunction object, the hydroxypropyl cellulose and hydroxyethyl cellulose is 1:1.
Be exclusively used in plant tooth during hypo-allergenic combination medicament preparation method it is as follows：Chinese medical extract is added to the water,
35 DEG C, rotating speed be 300r/min stir 30 minutes, be added bio-vitric, continue above-mentioned condition stir 30 minutes, anti-mistake is added
Quick dose, potassium citrate, antierythrite, sorbierite, N- sodium lauroyl sarcosines, Acritamer 940, continue above-mentioned condition stir 50
Minute, obtain being exclusively used in planting hypo-allergenic combination medicament during tooth.
Embodiment 3
One kind being exclusively used in hypo-allergenic combination medicament during plant tooth, including following components in parts by weight：
1 part of anti-allergic agent, 0.3 part of Chinese medical extract, 0.5 part of bio-vitric, 0.1 part of potassium citrate, 0.3 part of erythrose
Alcohol, 5 parts of sorbierites, 0.1 part of N- sodium lauroyl sarcosine, 3 parts of Acritamer 940s, 93 parts of water.The anti-allergic agent strontium acetate.Institute
The preparation method for stating Chinese medical extract is same as Example 1.
The preparation method of the bio-vitric is as follows：(1) template agent is prepared：By 1.2g cellulose derivatives, 0.1g N,
N '-methylene-bisacrylamides are dissolved in 300g water, are that 200r/min is stirred 40 minutes in 25 DEG C, rotating speed, 1.5g propylene is added
Tert-butyl acrylate is warming up to 35 DEG C, and 0.04g potassium peroxydisulfates are added, and is stirred 2 hours in 35 DEG C, the condition that rotating speed is 300 revs/min,
25 DEG C are subsequently cooled to, pH to 8.5 is adjusted with the sodium hydrate aqueous solution of a concentration of 0.2mol/L, in 25 DEG C, rotating speed 300
Rev/min condition stir 1 hour, then centrifuged 20 minutes with 10000 revs/min of rotating speed, take centrifugation gained sediment, set
It is 6 hours dry in 40 DEG C of drying box, obtain template agent；(2) 2.5mg template agents, 250mL water, 250mL ethyl alcohol are mixed equal
It is heated to 40 DEG C after even, 0.7g cetyl trimethylammonium bromides are added, the ammonium hydroxide that 10mL mass fractions are 25%-28%,
40 DEG C, rotating speed be 300r/min stir 20 minutes, obtain mixture, 8g tetraethyl orthosilicates, 0.65g triethyl phosphates taken to be dissolved in
It in 300mL absolute ethyl alcohols, is then added in above-mentioned mixture, is that 300r/min is stirred 120 minutes in 40 DEG C, rotating speed, is added
3.5g calcium chloride is continued to stir 48h in above-mentioned condition, then be centrifuged 20 minutes with 8000r/min, centrifugal sediment 500g second
It is 24 hours dry at 60 DEG C after alcohol washing, it is then placed in Muffle furnace, 850 DEG C is warming up to 10 DEG C/min of rates, at 850 DEG C
2h is kept the temperature, natural cooling obtains bio-vitric.The cellulose derivative is only hydroxypropyl cellulose.
Be exclusively used in plant tooth during hypo-allergenic combination medicament preparation method it is as follows：Chinese medical extract is added to the water,
35 DEG C, rotating speed be 300r/min stir 30 minutes, be added bio-vitric, continue above-mentioned condition stir 30 minutes, anti-mistake is added
Quick dose, potassium citrate, antierythrite, sorbierite, N- sodium lauroyl sarcosines, Acritamer 940, continue above-mentioned condition stir 50
Minute, obtain being exclusively used in planting hypo-allergenic combination medicament during tooth.
Embodiment 4
One kind being exclusively used in hypo-allergenic combination medicament during plant tooth, including following components in parts by weight：
1 part of anti-allergic agent, 0.3 part of Chinese medical extract, 0.5 part of bio-vitric, 0.1 part of potassium citrate, 0.3 part of erythrose
Alcohol, 5 parts of sorbierites, 0.1 part of N- sodium lauroyl sarcosine, 3 parts of Acritamer 940s, 93 parts of water.The anti-allergic agent strontium acetate.Institute
The preparation method for stating Chinese medical extract is same as Example 1.
The preparation method of the bio-vitric is as follows：(1) template agent is prepared：By 1.2g cellulose derivatives, 0.1gN, N '-
Methylene-bisacrylamide is dissolved in 300g water, is that 200r/min is stirred 40 minutes in 25 DEG C, rotating speed, 1.5g acrylic acid uncles are added
Butyl ester, is warming up to 35 DEG C, and 0.04g potassium peroxydisulfates are added, and stirs 2 hours in 35 DEG C, the condition that rotating speed is 300 revs/min, then
25 DEG C are cooled to, pH to 8.5 is adjusted with the sodium hydrate aqueous solution of a concentration of 0.2mol/L, is 300 revs/min in 25 DEG C, rotating speed
The condition of clock stirs 1 hour, is then centrifuged 20 minutes with 10000 revs/min of rotating speed, takes centrifugation gained sediment, be placed in 40
DEG C drying box in dry 6 hours, obtain template agent；(2) after mixing by 2.5mg template agents, 250mL water, 250mL ethyl alcohol
Be heated to 40 DEG C, 0.7g cetyl trimethylammonium bromides be added, the ammonium hydroxide that 10mL mass fractions are 25%-28%, 40 DEG C,
Rotating speed be 300r/min stir 20 minutes, obtain mixture, take 8g tetraethyl orthosilicates, 0.65g triethyl phosphates be dissolved in 300mL without
It in water-ethanol, is then added in above-mentioned mixture, is that 300r/min is stirred 120 minutes in 40 DEG C, rotating speed, 3.5g chlorinations are added
Calcium is continued to stir 48h in above-mentioned condition, then be centrifuged 20 minutes with 8000r/min, after centrifugal sediment is washed with 500g ethyl alcohol
It is 24 hours dry at 60 DEG C, it is then placed in Muffle furnace, 850 DEG C is warming up to 10 DEG C/min of rates, 2h is kept the temperature at 850 DEG C, from
It is so cooling, obtain bio-vitric.The cellulose derivative is only hydroxyethyl cellulose.
Be exclusively used in plant tooth during hypo-allergenic combination medicament preparation method it is as follows：Chinese medical extract is added to the water,
35 DEG C, rotating speed be 300r/min stir 30 minutes, be added bio-vitric, continue above-mentioned condition stir 30 minutes, anti-mistake is added
Quick dose, potassium citrate, antierythrite, sorbierite, N- sodium lauroyl sarcosines, Acritamer 940, continue above-mentioned condition stir 50
Minute, obtain being exclusively used in planting hypo-allergenic combination medicament during tooth.
Comparative example 1
It is substantially the same manner as Example 2, it differs only in：In this comparative example 1：
The preparation method of the bio-vitric is as follows：250mL water, 250mL ethyl alcohol are heated to 40 DEG C after mixing, added
Enter 0.7g cetyl trimethylammonium bromides, the ammonium hydroxide that 10mL mass fractions are 25%-28%, in 40 DEG C, rotating speed 300r/
Min is stirred 20 minutes, is obtained mixture, is taken 8g tetraethyl orthosilicates, 0.65g triethyl phosphates to be dissolved in 300mL absolute ethyl alcohols, so
After be added in above-mentioned mixture, 40 DEG C, rotating speed be 300r/min stir 120 minutes, be added 3.5g calcium chloride, continue upper
State condition stirring 48h, then with 8000r/min centrifuge 20 minutes, centrifugal sediment washed with 500g ethyl alcohol after in 60 DEG C of dryings
It 24 hours, is then placed in Muffle furnace, 850 DEG C is warming up to 10 DEG C/min of rates, 2h is kept the temperature at 850 DEG C, natural cooling obtains
To bio-vitric.
Comparative example 2
One kind being exclusively used in hypo-allergenic combination medicament during plant tooth, including following components in parts by weight：
1 part of anti-allergic agent, 0.5 part of bio-vitric, 0.1 part of potassium citrate, 0.3 part of antierythrite, 5 parts of sorbierites, 0.1 part
N- sodium lauroyl sarcosines, 3 parts of Acritamer 940s, 93 parts of water.The anti-allergic agent strontium acetate.
The preparation method of the bio-vitric is same as Example 2.
Be exclusively used in plant tooth during hypo-allergenic combination medicament preparation method it is as follows：Bio-vitric is added to the water, 35
DEG C, rotating speed be 300r/min stir 30 minutes, be added anti-allergic agent, potassium citrate, antierythrite, sorbierite, N- lauroyl fleshes
Propylhomoserin sodium, Acritamer 940 continue to stir 50 minutes in above-mentioned condition, obtain being exclusively used in planting hypo-allergenic combination medicament during tooth.
Test case
(1) fungistatic effect is tested：
Experimental group：Hypo-allergenic combination medicament 9mL during being exclusively used in planting tooth is taken, is added in sterile glass test tube, 1mL is added
(shading value (O.D) is 0.1 to Escherichia coli bacteria liquid, clump count 106CFU/mL), the uniformly mixed constant temperature incubation for being placed on 37 DEG C
It is cultivated 12 hours in case, measures the light absorption value of mixed liquor in the sterile test tube after culture.Control group：9mL physiological saline is taken to replace
It is exclusively used in hypo-allergenic combination medicament during planting tooth and carries out above-mentioned experiment.Bacteriostasis rate calculation formula：(the extinction after control group culture
Light absorption value after value-experimental group culture) light absorption value × 100% after/control group culture.Test result is shown in Table 1.
Table 1：Bacteriostasis rate test result table
(2) periodontitis curative effect is tested：
Patient data：Patients with 300 Cases, male 150, women 150.On inspection, the symptom of patient is that simple gum is red
Swollen, kermesinus, gingival sulcus are deepened, gingival sulcus pyorrhea, the rotten to the corn simultaneously gum severe haemorrhage of gum edge, gum congestion and edema.All cases anodontia
Loose compact person.Nothing takes any antiphlogistic before medical.300 patients are divided into 6 groups, every group 50, including male 25, female
Property 25.There was no significant difference in age, the state of an illness by 6 groups of patients, is comparable.
Therapy：Hypo-allergenic combination medicine during being exclusively used in plant tooth to the spraying of the teeth roots of the inflammation of patient every time
Agent, every tooth corresponding position spray 0.3mL.It is each primary daily morning and evening.
Criterion of therapeutical effect：It is effective：Bleeding gums stop after medication 1-3 days, and gum congestion and edema subsides substantially, halitosis disappears.
Effectively：Bleeding gums stop after medication 3-7 days, and red and swollen basic recession, halitosis is substantially reduced or disappears.In vain：Disease after medication 7 days
Shape is not improved.
Table 2：Periodontitis curative effect test result table
| It is effective | Effectively | In vain | |
| Embodiment 1 | 26 | 18 | 6 |
| Embodiment 2 | 38 | 12 | 0 |
| Embodiment 3 | 33 | 15 | 2 |
| Embodiment 4 | 30 | 18 | 2 |
| Comparative example 1 | 27 | 19 | 4 |
| Comparative example 2 | 25 | 20 | 5 |
The hypo-allergenic combination medicament during being exclusively used in planting tooth of the present invention, has no toxic side effect, containing there are many Chinese herbal medicine, additions
With antibacterial, hemostasia effect bio-vitric, meet traditional Chinese medicine and pharmacy and modern medical theory, it can effectively antibacterial, hemostasis, anti-mistake
It is quick, stablize surface of a wound surrounding tissue, wound healing and gingiva tissue regeneration, can be used for planting hemostasis during tooth, anti-inflammatory and
It is hypo-allergenic.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that those skilled in the art without
It needs creative work according to the present invention can conceive and makes many modifications and variations.Therefore, all technologies in the art
Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Technical solution, all should be in the protection domain being defined in the patent claims.
Claims (10)
1. one kind being exclusively used in hypo-allergenic combination medicament during plant tooth, which is characterized in that including following components：
Anti-allergic agent, Chinese medical extract, potassium citrate, antierythrite, sorbierite, N- sodium lauroyl sarcosines, carbomer, water.
2. one kind being exclusively used in hypo-allergenic combination medicament during plant tooth, which is characterized in that including following components in parts by weight：
0.8-1.5 parts of anti-allergic agents, 0.1-0.5 parts of Chinese medical extracts, 0.05-0.15 parts of potassium citrates, 0.2-0.6 parts of erythroses
Alcohol, 2-8 part sorbierite, 0.06-0.3 parts of N- sodium lauroyl sarcosines, 0.5-3.5 parts of carbomers, 90-100 parts of water.
3. one kind being exclusively used in hypo-allergenic combination medicament during plant tooth, which is characterized in that including following components in parts by weight：
0.8-1.5 parts of anti-allergic agents, 0.1-0.5 parts of Chinese medical extracts, 0.3-1 parts of bio-vitrics, 0.05-0.15 parts of citric acids
Potassium, 0.2-0.6 part antierythrite, 2-8 parts of sorbierites, 0.06-0.3 parts of N- sodium lauroyl sarcosines, 0.5-3.5 parts of carbomers,
90-100 parts of water.
4. hypo-allergenic combination medicament according to any one of claim 1-3 during being exclusively used in plant tooth, which is characterized in that
The anti-allergic agent is one kind in strontium chloride, strontium acetate.
5. hypo-allergenic combination medicament according to any one of claim 1-3 during being exclusively used in plant tooth, which is characterized in that
The carbomer is Acritamer 940.
6. hypo-allergenic combination medicament according to any one of claim 1-3 during being exclusively used in plant tooth, which is characterized in that
The preparation method of the Chinese medical extract is as follows：By Fructus Forsythiae, big goat's horn wooden dipper, Radix Glycyrrhizae, asarum, it is windproof in mass ratio be 1:(1-2):
(2-4):(1-2):It is crushed after (1-3) mixing, crosses 10-50 mesh sieve, obtain herb powder, take 20-35g herb powders that 100- is added
In 200mL water, 0.01-0.05g mixed enzymes are added, is uniformly mixed, is warming up to 35-37 DEG C, 28-32h is kept the temperature at 35-37 DEG C, rise
Temperature keeps the temperature 3-5 minutes to 95-100 DEG C, at 95-100 DEG C, is cooled to 28-32 DEG C, crosses 100-300 mesh sieve, obtain first-time filtrate and
Filter cake is added in the ethanol water that 80-120mL volume fractions are 60-75%, is warming up to 65-75 DEG C by filter cake,
It is that 200-500r/min is stirred 1-4 hours in 65-75 DEG C, rotating speed, crosses 100-300 mesh sieve, obtain secondary filtrate and secondary filter cake,
Merge first-time filtrate and secondary filtrate obtains mixing filtrate, mixing filtrate is concentrated into the 1/30~1/10 of proper mass, will be concentrated
Liquid is dried 4-8 hour in 35-45 DEG C, 0.01-0.03MPa conditions, obtains Chinese medical extract, the mixed enzyme be cellulase,
Pectase, neutral proteinase are (1-3) in mass ratio:1:The mixture of (1-2).
7. according to the hypo-allergenic combination medicament during being exclusively used in planting tooth described in claim 3, which is characterized in that the biology
The preparation method of glass includes the following steps：(1) template agent is prepared：By 1-2g cellulose derivatives, 0.05-0.15g N, N '-
Methylene-bisacrylamide is dissolved in 250-350g water, is that 100-300r/min is stirred 30-60 minutes in 25-30 DEG C, rotating speed, is added
Enter 1-3g tert-butyl acrylates, be warming up to 35-40 DEG C, 0.03-0.06g initiators is added, in 35-40 DEG C, rotating speed 200-500
Rev/min condition stir 1-3 hours, be subsequently cooled to 25-28 DEG C, the sodium hydroxide with a concentration of 0.1-0.5mol/L is water-soluble
Liquid adjusts pH to 8-9, is stirred 0.5-1.5 hours in 25-28 DEG C, the condition that rotating speed is 300-500 revs/min, then with 8000-
12000 revs/min of rotating speed centrifuges 10-30 minutes, takes centrifugation gained sediment, is placed in 40-45 DEG C of drying box dry 4-8
Hour, obtain template agent；(2) 2-3mg template agents, 200-300mL water, 200-300mL ethyl alcohol are heated to 38- after mixing
42 DEG C, 0.5-1g cetyl trimethylammonium bromides are added, the ammonium hydroxide that 8-12mL mass fractions are 25%-28%, in 38-42
DEG C, rotating speed be 200-500r/min stir 10-40 minutes, obtain mixture, take 5-10g tetraethyl orthosilicates, 0.4-0.8g phosphoric acid
Triethyl is dissolved in 250-350mL absolute ethyl alcohols, is then added in above-mentioned mixture, in 38-42 DEG C, rotating speed 200-
500r/min is stirred 100-150 minutes, and 3-4g calcium chloride is added, and continues to stir 36-52h in above-mentioned condition, then with 5000-
10000r/min is centrifuged 10-30 minutes, and centrifugal sediment is 18-26 hours dry at 50-70 DEG C after being washed with 400-600g ethyl alcohol,
Then it is placed in Muffle furnace, 800-900 DEG C is warming up to 8-12 DEG C/min of rate, 1.5-2.5h is kept the temperature at 800-900 DEG C, from
It is so cooling, obtain bio-vitric.
8. hypo-allergenic combination medicament according to claim 7 during being exclusively used in plant tooth, which is characterized in that the cellulose
Derivative is hydroxypropyl cellulose and/or hydroxyethyl cellulose.
9. hypo-allergenic combination medicament according to claim 8 during being exclusively used in plant tooth, which is characterized in that the cellulose
Derivative is the mixture of hydroxypropyl cellulose and hydroxyethyl cellulose, the matter of the hydroxypropyl cellulose and hydroxyethyl cellulose
Amount is than being (1-3)：(1-3).
10. hypo-allergenic combination medicament according to claim 7 during being exclusively used in plant tooth, which is characterized in that the initiation
Agent is potassium peroxydisulfate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810791173.8A CN108653398B (en) | 2018-07-18 | 2018-07-18 | Anti-allergy combined medicament special for tooth implantation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810791173.8A CN108653398B (en) | 2018-07-18 | 2018-07-18 | Anti-allergy combined medicament special for tooth implantation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108653398A true CN108653398A (en) | 2018-10-16 |
| CN108653398B CN108653398B (en) | 2021-06-04 |
Family
ID=63788538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810791173.8A Active CN108653398B (en) | 2018-07-18 | 2018-07-18 | Anti-allergy combined medicament special for tooth implantation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108653398B (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991562A (en) * | 2009-08-03 | 2011-03-30 | 麦克内尔-Ppc股份有限公司 | Tooth sensitivity treatment compositions |
| CN102293916A (en) * | 2011-09-09 | 2011-12-28 | 周慧 | Medicine for treating orthodontic gingivitis |
| CN102784082A (en) * | 2012-08-02 | 2012-11-21 | 陈斌 | Antiallergic tooth-protection toothpaste |
| CN102908287A (en) * | 2012-10-23 | 2013-02-06 | 安徽省王巢食品有限公司 | Chinese and western medicine composite preparation toothpaste with propolis and preparation method thereof |
| CN103041343A (en) * | 2012-12-31 | 2013-04-17 | 王会祥 | Medicament for treating children's gingivitis |
| CN103340896A (en) * | 2013-07-10 | 2013-10-09 | 山东赛克赛斯药业科技有限公司 | Duplex dentin hypersensitivity resistant composition and application thereof |
| CN105534875A (en) * | 2015-12-24 | 2016-05-04 | 重庆登康口腔护理用品股份有限公司 | Anti-bacterial anti-allergy composition for oral care products, toothpaste and preparation method of toothpaste |
| CN106109493A (en) * | 2016-08-05 | 2016-11-16 | 四川北极光口腔医疗器械有限公司 | One is exclusively used in hypo-allergenic combination medicament during planting tooth |
| CN106176969A (en) * | 2015-05-05 | 2016-12-07 | 刘宽明 | A kind of control the formula that skin infection furuncle and phyma, deficiency-heat are the most peaceful |
| CN107434844A (en) * | 2016-11-26 | 2017-12-05 | 中国人民解放军第四军医大学 | The synthetic method of quaternized silica bio-vitric nanoparticle and application |
| CN107986630A (en) * | 2017-11-30 | 2018-05-04 | 华南协同创新研究院 | A kind of preparation method of nano-bioactive glass powder |
-
2018
- 2018-07-18 CN CN201810791173.8A patent/CN108653398B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991562A (en) * | 2009-08-03 | 2011-03-30 | 麦克内尔-Ppc股份有限公司 | Tooth sensitivity treatment compositions |
| CN102293916A (en) * | 2011-09-09 | 2011-12-28 | 周慧 | Medicine for treating orthodontic gingivitis |
| CN102784082A (en) * | 2012-08-02 | 2012-11-21 | 陈斌 | Antiallergic tooth-protection toothpaste |
| CN102908287A (en) * | 2012-10-23 | 2013-02-06 | 安徽省王巢食品有限公司 | Chinese and western medicine composite preparation toothpaste with propolis and preparation method thereof |
| CN103041343A (en) * | 2012-12-31 | 2013-04-17 | 王会祥 | Medicament for treating children's gingivitis |
| CN103340896A (en) * | 2013-07-10 | 2013-10-09 | 山东赛克赛斯药业科技有限公司 | Duplex dentin hypersensitivity resistant composition and application thereof |
| CN106176969A (en) * | 2015-05-05 | 2016-12-07 | 刘宽明 | A kind of control the formula that skin infection furuncle and phyma, deficiency-heat are the most peaceful |
| CN105534875A (en) * | 2015-12-24 | 2016-05-04 | 重庆登康口腔护理用品股份有限公司 | Anti-bacterial anti-allergy composition for oral care products, toothpaste and preparation method of toothpaste |
| CN106109493A (en) * | 2016-08-05 | 2016-11-16 | 四川北极光口腔医疗器械有限公司 | One is exclusively used in hypo-allergenic combination medicament during planting tooth |
| CN107434844A (en) * | 2016-11-26 | 2017-12-05 | 中国人民解放军第四军医大学 | The synthetic method of quaternized silica bio-vitric nanoparticle and application |
| CN107986630A (en) * | 2017-11-30 | 2018-05-04 | 华南协同创新研究院 | A kind of preparation method of nano-bioactive glass powder |
Non-Patent Citations (1)
| Title |
|---|
| 中人民解放军第四军医大学: "《口腔内科学讲义 试用》", 31 October 1971, 中人民解放军第四军医大学 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108653398B (en) | 2021-06-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101297889B (en) | Chinese medicine preparation for treating foot-and-mouth disease and preparation method thereof | |
| CN104337976A (en) | Traditional Chinese medicine composition for improving immunity of beasts and birds | |
| CN105106081A (en) | Chinese herbal toothpaste used for oral inflammation and preparation method of Chinese herbal toothpaste | |
| CN103251741B (en) | Chinese medicine composition for treating toxoplasmosisinswine, and preparation method and application thereof | |
| CN101249255B (en) | Proprietary Chinese medicine for curing children's cough and method of preparing the same | |
| CN108653398A (en) | One kind being exclusively used in hypo-allergenic combination medicament during plant tooth | |
| CN103989762B (en) | Chinese medicine composition of internal organs relieving cough and resolving phlegm and preparation method thereof is rushed down in a kind of heat clearing away | |
| CN102727804B (en) | Traditional Chinese medicine composition for treating abscess and boil and preparation method thereof | |
| CN105535502A (en) | Traditional Chinese medicine preparation for treating adult periodontitis and preparation method of traditional Chinese medicine preparation | |
| CN105031284A (en) | Oral medicament for treatment of oral leukoplakia | |
| CN110339107A (en) | A kind of schefflera arboricola gum analgesic health-care toothpaste and preparation method thereof | |
| CN103181964B (en) | Traditional Chinese medicine composition for treating animal body surface injuries and preparation method thereof | |
| CN108514624A (en) | A kind of prepared slices of Chinese crude drugs and preparation method thereof for oral care | |
| CN109700710A (en) | Eucommia bark toothpaste and preparation method thereof | |
| CN105381336A (en) | Biological agent containing papaya extract and application thereof | |
| CN105327077A (en) | Traditional Chinese medicine composition for treating periodontitis and preparation method and application thereof | |
| CN104623268A (en) | Traditional Chinese medicine composition for treating and preventing postpartum hypogalactia of women | |
| CN104208597A (en) | Chinese medicinal formula for treating kidney stone | |
| CN108379534A (en) | A kind of Chinese medicine external composition of hair growth and preparation method thereof | |
| CN117205140A (en) | Lipid-lowering toothpaste containing biological enzyme-based composition and preparation method thereof | |
| CN103830651A (en) | Oral cavity fungistat and preparation method thereof | |
| CN109966361A (en) | A kind of fructus hippophae aerosol and preparation method thereof | |
| CN109771520A (en) | A kind of Chinese medicine composition for treating lung pain | |
| CN108126040A (en) | A kind of preparation method of the traditional Chinese medicine reagent for preventing eczema, washing lotion and ointment | |
| CN108704092A (en) | It is a kind of to treat hemiplegia caused by hypertension, blood pressure lowering pill and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230823 Address after: 101200 room 205-211526, No. 40, Fuqian West Street, Pinggu town, Pinggu District, Beijing (cluster registration) Patentee after: BEIJING YONGBO TECHNOLOGY CO.,LTD. Address before: Room 101, building 1, No. 533, Fangzhou Road, Suzhou Industrial Park, Jiangsu Province 215000 Patentee before: SUZHOU INDUSTRIAL PARK FANGJIN DENTAL CLINIC CO.,LTD. |