CN110522675A - Effectively antibacterial mouthwash and preparation method - Google Patents
Effectively antibacterial mouthwash and preparation method Download PDFInfo
- Publication number
- CN110522675A CN110522675A CN201910968045.0A CN201910968045A CN110522675A CN 110522675 A CN110522675 A CN 110522675A CN 201910968045 A CN201910968045 A CN 201910968045A CN 110522675 A CN110522675 A CN 110522675A
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- CN
- China
- Prior art keywords
- nisin
- antibacterial
- natamycin
- water
- phenyllactic acid
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 40
- 239000002324 mouth wash Substances 0.000 title claims abstract description 30
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 claims abstract description 23
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- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical group O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 claims abstract description 23
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- RWAXQWRDVUOOGG-UHFFFAOYSA-N N,2,3-Trimethyl-2-(1-methylethyl)butanamide Chemical compound CNC(=O)C(C)(C(C)C)C(C)C RWAXQWRDVUOOGG-UHFFFAOYSA-N 0.000 claims abstract description 16
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims abstract description 10
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- A61P31/10—Antimycotics
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Abstract
Effectively antibacterial mouthwash and preparation method thereof, it is made of refine glycerol, peppermint oil, lauryl sodium sulfate, freshener WS-23, anticaking agent, sweetener and water-based of gargling of antibacterial bio-extract, sodium bicarbonate, biology, antibacterial bio-extract is natamycin, nisin and phenyllactic acid, natamycin, nisin, phenyllactic acid are weighed be added in pure water stirred by reaction kettle to dissolution after other components are added, high-speed stirred to all substances dissolve, finally by packing after sterile filling.Contain natamycin, nisin and phenyllactic acid in mouthwash of the present invention, can effectively kill and inhibit the G such as porphyromonas gingivalis, bacterium actinomycetem comitans, Fusobacterium, the streptococcus mutans in oral cavity+、G‑Bacterium, and the plaque bio-film generated simultaneously to flora has decomposition, can decompose plaque simultaneously in protection beneficial bacteria, the effect of cleaning the teeth while sterilizing nti-freckle.
Description
Technical field
The present invention relates to oral health care technical fields, and in particular to a kind of effectively antibacterial mouthwash and preparation side
Method.
Background technique
Bacterial plaque is also known as Dental plaque biofilm, refers to and is attached on dental surface, other soft tissues of oral cavity either dummy
On, it is by a large amount of intercellular substance such as protein, polysaccharide, teichoic acid, a small amount of leucocyte, the epithelial cell and food to fall off
The composition such as object residue, in one layer of biomembrane that dental surface is formed, intraoral bacterium attaches on film successively, and bacterium passes through
Stick and copolymerization is interconnected, is proliferated, forms complicated flora, be a kind of bacillary deposit of not mineralising, according to bacterial plaque
In bacterial species and adsorption site difference, plaque can be divided into supragingival plaque and subgingival plaque, on smooth surface caries and gum
Bacterial plaque is mainly streptococcus mutans, and point lacuna ditch bacterial plaque is mainly coccus, and plaque is the arch-criminal of saprodontia and periodontosis, institute
Mainly to control bacterial plaque, pre- anti-caries are also to need to control bacterial plaque in pre- preventing parodontitis, gingivitis.Oral cavity is
One has collarium border, and the warm nutrition for bacterium is moistened in oral cavity and is enriched again, bacterium is very easy to accumulation, Staphylococcus aureus
Bacterium, Candida albicans, streptococcus mutans, Bacillus acidi lactici, porphyromonas gingivalis are oral cavity common bacteria, can not be complete in oral cavity
Completely without bacterium, it is also not possible to all bacteriums all be destroyed, flora imbalance is caused to infect, such as fungal infection will cause more sternly
The consequence of weight.
Have on the market at present containing anti-inflammation components such as broad-spectrum antibiotics in many mouthwashes, and anti-inflammatory is exactly to inhibit and kill
Flora in oral cavity, in this case, profitable strain also inhibition and death under the interference of broad-spectrum antibiotic, leads to flora in oral cavity
In addition disorder can make using containing broad-spectrum antibiotic anti-inflammation drugs for a long time to move towards other mouth diseases such as inflammation, saprodontia
It is intraoral bacterial resistance occurred.In addition also some mouthwashes contain the stimulating components such as alcohol on the market, itself is to oral cavity
There is certain irritation, such as the time is longer, and some harmful chemicals can pass through mucous membrane of mouth and tongue containing gargling in the oral cavity
Absorb and enter in vivo, according to " drug direct oral cavity mucosal absorption " Japan medical science introduce 1989 volume 10 the 1st it is interim mention, pass through
The drug of oral mucosal absorption without liver, and is directly entered human circulation.It is buccal absorption situation in table one, from table
In it can be seen that the absorptivity of sublingual mucous membrane is exceedingly fast, human body can be made by accidentally absorbing harmful irritant mouthwash as a result,
At different degrees of injury.In addition, the dental products that other oral-cavity articles work just for intraoral bacterium on the market,
And for the biomembrane of plaque generation, there is no effective therapeutic effects, continue to be attached to tooth after causing bacterium extremely to restore combustion
On the biomembrane on surface, palliative phenomenon is caused.
Summary of the invention
The present invention is in view of the deficienciess of the prior art, provide a kind of effectively antibacterial mouthwash and preparation method.
The technical solution adopted by the present invention to solve the technical problems is:
A kind of effectively antibacterial mouthwash is refined glycerol, peppermint oil, dodecane by antibacterial bio-extract, sodium bicarbonate, biology
Base sodium sulphate, freshener WS-23, anticaking agent, sweetener and water-based of gargling composition, antibacterial bio-extract be natamycin,
Nisin and phenyllactic acid.
Above-mentioned anticaking agent is that potassium ferrocyanide and calcium carbonate are one such or two kinds.
Above-mentioned sweetener is that malto-oligosaccharide glucose, fructose oligosaccharides, soyabean oligosaccharides, different qualityxylans and different malt are low
Glycan is one such or two kinds.
Above-mentioned water-based of gargling is that sodium lactate, sodium chloride, potassium chloride, disodium hydrogen phosphate and pure water are one such or two
Kind.
Above-mentioned each component account for gross mass mass ratio be natamycin 0.03% to 0.5%, nisin 0.03% to
0.8%, phenyllactic acid 0.02% to 0.5%, sodium bicarbonate 0.08% to 0.2%, biology are refined glycerol 0.05% to 0.2%, peppermint oil
0.05% to 0.13%, lauryl sodium sulfate 0.03% to 0.15%, freshener WS-23 0.05% to 0.2%, anticaking agent 0.01 to
0.2%, sweetener 0.05% to 0.2%, surplus are water-based of gargling.
The preparation method of above-mentioned effectively antibacterial mouthwash, weighs addition for natamycin, nisin, phenyllactic acid
Sodium bicarbonate, biology are added after stirring by reaction kettle to dissolution into 40 DEG C of pure water to refine glycerol, peppermint oil, dodecyl
Sodium sulphate, sweetener, freshener WS-23, anticaking agent and water-based of gargling mixing, high-speed stirred to all substances dissolve, and adjust
PH value is packed after passing through sterile filling after cooling between 6.6 to 7.1.
Mouthwash of the present invention in use, daily after meal or feed after can rinse oral cavity at any time, 30S is stopped in oral cavity, press down
System and killing pernicious bacteria, disintegrate biomembrane, and rinse up and down by intraoral pressure, effectively wash away teeth space and surface
Swill and tartar, achieve the purpose that clean the teeth.
In traditional Chinese medicine reagent formula of the present invention: freshener WS-23 is N, 2,3- trimethyl -2- butanamide；Receive that he is mould
Element is the filamentous fungis inhibitor such as natural one kind, the saccharomycete of wide spectrum, highly effective and safe and mould, it can not only inhibit fungi,
The generation of mycotoxin can also be prevented, natamycin is harmless, is difficult to be absorbed by human body alimentary canal, and microorganism is difficult
Resistance is generated to it, the mechanism of action is to check ergosterol biology in conjunction with the ergosterol of fungi and other sterol groups
Synthesis, so that cell membrane be made to distort, eventually leads to leakage, causes cell death.Natamycin is especially for intraoral beads
Bacterium disease (being commonly called as thrush) has stronger sterilization and inhibiting effect；Benzene cream bacterium is a kind of natural biological antibacterial substance, to people and is moved
Object cytotoxic, phenyllactic acid have wide antimicrobial spectrum to fungi, have inhibition to make G+ bacterium, G- bacterium and eukaryotic microorganisms
With；The polypeptide compounds that nisin is made of 34 amino acid, the product as biofermentation can be used as nutrients
Matter is absorbed by the body utilization, and antibacterial action is the normal function by interfering cell v film, causes the infiltration of cell membrane, nutrient
It is lost and film potential declines, and have strong inhibiting effect to the spore of bacillus, it is thin so as to cause pathogenic bacteria and spoilage organisms
The death of born of the same parents.
Contain natamycin, nisin and phenyllactic acid in mouthwash of the present invention, can effectively kill and inhibit oral cavity
The G such as porphyromonas gingivalis, bacterium actinomycetem comitans, Fusobacterium, streptococcus mutans+、G-Bacterium, and the bacterium that flora is generated simultaneously
Spot biomembrane has decomposition, in protection beneficial bacteria decomposable plaque simultaneously, has while sterilizing nti-freckle and cleans the teeth
Effect.
Specific embodiment
Example 1
A kind of effectively antibacterial mouthwash is refined glycerol, peppermint oil, dodecane by antibacterial bio-extract, sodium bicarbonate, biology
Base sodium sulphate, freshener WS-23, anticaking agent, sweetener and water-based of gargling composition, anticaking agent is calcium carbonate, and antibacterial biology mentions
Taking object is natamycin, nisin and phenyllactic acid, and sweetener is malto-oligosaccharide glucose and soyabean oligosaccharides, is gargled
Water-based is sodium lactate and pure water, and the mass ratio that each component accounts for gross mass is natamycin 0.03%, nisin
0.03%, phenyllactic acid 0.02%, sodium bicarbonate 0.08%, biology are refined glycerol 0.05%, peppermint oil 0.05%, lauryl sodium sulfate
0.03%, malto-oligosaccharide glucose 0.05%, soyabean oligosaccharides 0.05%, freshener WS-23 0.05%, calcium carbonate 0.01%, cream
Sour sodium 0.02%, surplus are pure water.
The preparation method of above-mentioned effectively antibacterial mouthwash, natamycin, nisin, phenyllactic acid are weighed as above
Weight is added in 40 DEG C of pure water to stir 45S by reaction kettle sodium bicarbonate, biology are added to after dissolving and refine glycerol, peppermint
Oil, lauryl sodium sulfate, malto-oligosaccharide glucose, soyabean oligosaccharides, freshener, calcium carbonate, sodium lactate mixing, high-speed stirring
It mixes 15M to dissolve to all substances, adjusts pH value between 6.6 to 7.1, packed after passing through sterile filling after cooling.
Example 2
A kind of effectively antibacterial mouthwash is refined glycerol, peppermint oil, dodecane by antibacterial bio-extract, sodium bicarbonate, biology
Base sodium sulphate, freshener WS-23, anticaking agent, sweetener and water-based of gargling composition, anticaking agent is calcium carbonate, and antibacterial biology mentions
Taking object is natamycin, nisin and phenyllactic acid, and sweetener is soyabean oligosaccharides and different qualityxylans, and water-based of gargling is
Disodium hydrogen phosphate and pure water, the mass ratio that each component accounts for gross mass is natamycin 0.2%, nisin 0.3%, benzene
Lactic acid 0.2%, sodium bicarbonate 0.1%, biology are refined glycerol 0.09%, peppermint oil 0.09%, lauryl sodium sulfate 0.09%, soybean
Oligosaccharide 0.07%, different qualityxylans 0.05%, freshener WS-23 0.1%, calcium carbonate 0.05%, disodium hydrogen phosphate 0.06%, surplus are
Pure water.
The preparation method of above-mentioned effectively antibacterial mouthwash, natamycin, nisin, phenyllactic acid are weighed as above
Weight is added in 40 DEG C of pure water to stir 45S by reaction kettle sodium bicarbonate, biology are added to after dissolving and refine glycerol, peppermint
Oil, lauryl sodium sulfate, soyabean oligosaccharides, different qualityxylans, freshener WS-23, calcium carbonate, disodium hydrogen phosphate mixing, high speed
It stirs 15M to dissolve to all substances, adjusts pH value between 6.6 to 7.1, packed after passing through sterile filling after cooling.
Example 3
A kind of effectively antibacterial mouthwash is refined glycerol, peppermint oil, dodecane by antibacterial bio-extract, sodium bicarbonate, biology
Base sodium sulphate, freshener WS-23, anticaking agent, sweetener and water-based of gargling composition, anticaking agent is potassium ferrocyanide, antibacterial life
Object extract is natamycin, nisin and phenyllactic acid, and sweetener is fructose oligosaccharides and isomalto-oligosaccharide, is gargled
Water-based is sodium lactate and pure water, and the mass ratio that each component accounts for gross mass is natamycin 0.5%, nisin
0.8%, phenyllactic acid 0.5%, sodium bicarbonate 0.2%, biology are refined glycerol 0.2%, peppermint oil 0.013%, lauryl sodium sulfate
0.15%, fructose oligosaccharides 0.15%, isomalto-oligosaccharide 0.09%, freshener WS-23 0.2%, potassium ferrocyanide 0.1%, lactic acid
Sodium 0.2%, surplus are pure water.
The preparation method of above-mentioned effectively antibacterial mouthwash, natamycin, nisin, phenyllactic acid are weighed as above
Weight is added in 40 DEG C of pure water to stir 45S by reaction kettle sodium bicarbonate, biology are added to after dissolving and refine glycerol, peppermint
Oil, lauryl sodium sulfate, fructose oligosaccharides, isomalto-oligosaccharide, freshener WS-23, potassium ferrocyanide, sodium lactate mixing,
High-speed stirred 15M is dissolved to all substances, adjusts pH value between 6.6 to 7.1, is packed after passing through sterile filling after cooling.
Mouthwash prepared by the present invention carries out bacteriostatic experiment 1
Prepare bacterium solution: by staphylococcus aureus, lactobacillus acidophilus, Candida albicans, Streptococcus mutans, actinobacillus actinomycetem comitans
Strain is placed in 37 DEG C of culture 15h in nutrient broth medium；Take culture solution 1ml that the aseptic sodium chloride solution of 9ml 0.9% is added,
Using 10 times of incremental dilution methods, it is diluted to 100cfu/ml, it is spare；
Test bacteria liquid made from above-mentioned steps is uniformly mixed in the corresponding nutrient agar of every kind of bacterium, plate is poured, it is cooling,
Punching is added in hole and gargles book (having multiple holes) accordingly；Plate is inverted into incubator after 37 DEG C of cultures measurement for 24 hours
Each medicine antibacterial circle diameter, is then convert into antibacterial area；
Experimental observation measurement: S (antibacterial area)=S (measurement area)-S (perforated area)
0.02% group of phenyllactic acid of the natamycin 0.03%+ nisin 0.03%+ antibacterial area such as following table one to bacterium:
Table one
Natamycin 0.2%, nisin 0.3%, 0.2% group of the phenyllactic acid antibacterial area such as following table two to bacterium:
Table two
Natamycin 0.5%, nisin 0.8%, 0.5% group of the phenyllactic acid antibacterial area such as following table three to bacterium:
Table three
Three kinds of gargles have preferable fungistatic effect, meeting to bacterium such as staphylococcus aureus, Candida albicans, Streptococcus mutans
According to the increase fungistatic effect growth in direct ratio of content, comprehensively considering proves that biological mouthwash of the invention has significant suppression
Bacterium effect can play preferable antibacterial bacteriostatic effect.
Bacteriostatic experiment 2
The preparation of bacteria suspension: sterile distilled water 5mL is used, staphylococcus aureus, Escherichia coli, Candida albicans are used respectively
The phosphate buffer of 0.03mol/L is diluted to bacteria suspension.
Bacteria suspension quantitative disinfecting test: tri- kinds of different mouthwashes of 5.0mL are taken in sterile test tube respectively, then take bacterium respectively
100 μ L of suspension is added to tri- kinds of bacterium mouthwashes of 5.0mL and mixes, effect to 1min time, and it is golden yellow to be inverted culture in 37 DEG C of incubators
Staphylococcus, Candida albicans, Escherichia coli count flat-plate bacterial colony number, and empirical average three times, is averaged, and calculate sterilizing rate.
Test result is as shown in Table 4.
Table four
By table four as it can be seen that mouthwash of the invention, can kill Escherichia coli, staphylococcus aureus and Candida albicans in the short time
Bacterium.
Claims (6)
1. a kind of effectively antibacterial mouthwash, it is characterized in that being refined glycerol, thin by antibacterial bio-extract, sodium bicarbonate, biology
Lotus oil, lauryl sodium sulfate, freshener WS-23, anticaking agent, sweetener and water-based of gargling composition, antibacterial bio-extract
For natamycin, nisin and phenyllactic acid.
2. effectively antibacterial mouthwash according to claim 1, it is characterized in that anticaking agent is potassium ferrocyanide and calcium carbonate
It is one such or two kinds.
3. effectively antibacterial mouthwash according to claim 1, it is characterized in that sweetener is malto-oligosaccharide glucose, fruit
Sugared oligosaccharide, soyabean oligosaccharides, different qualityxylans and isomalto-oligosaccharide are one such or two kinds.
4. effectively antibacterial mouthwash according to claim 1, it is characterized in that water-based of gargling be sodium lactate, sodium chloride,
Potassium chloride, disodium hydrogen phosphate and pure water are one such or two kinds.
5. effectively antibacterial mouthwash according to claim 1, it is characterized in that the mass ratio that each component accounts for gross mass is
Natamycin 0.03% to 0.5%, nisin 0.03% to 0.8%, phenyllactic acid 0.02% to 0.5%, sodium bicarbonate 0.08% to
0.2%, biology refine glycerol 0.05% to 0.2%, peppermint oil 0.05% to 0.13%, lauryl sodium sulfate 0.03% to 0.15%,
Freshener WS-23 0.05% to 0.2%, anticaking agent 0.01 to 0.2%, sweetener 0.05% to 0.2%, surplus are water-based of gargling.
6. the preparation method of effective antibacterial mouthwash described in claim 1 or 1 or 2 or 3 or 4 or 5, it is characterized in that he will be received
Mycin, nisin, phenyllactic acid weigh be added to stirred by reaction kettle to dissolution in 40 DEG C of pure water after carbonic acid is added
Hydrogen sodium, biology are refined glycerol, peppermint oil, lauryl sodium sulfate, sweetener, freshener WS-23, anticaking agent and water-based of gargling
Mixing, high-speed stirred to all substances dissolve, and adjust pH value between 6.6 to 7.1, pack after passing through sterile filling after cooling.
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| CN110974727A (en) * | 2019-12-27 | 2020-04-10 | 西安艾姆高分子材料有限公司 | Long-acting antibacterial mouthwash and preparation method thereof |
| WO2020223082A1 (en) * | 2019-04-29 | 2020-11-05 | Sunstar Americas, Inc. | Oral care composition |
| CN113702559A (en) * | 2021-08-16 | 2021-11-26 | 江南大学 | Method for separating and identifying active substances of lactobacillus plantarum source inhibiting double-bacterium biological membrane |
| CN115429734A (en) * | 2021-10-28 | 2022-12-06 | 斯钦 | Mouthwash for diminishing inflammation and clearing internal heat and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020223082A1 (en) * | 2019-04-29 | 2020-11-05 | Sunstar Americas, Inc. | Oral care composition |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN110974727A (en) * | 2019-12-27 | 2020-04-10 | 西安艾姆高分子材料有限公司 | Long-acting antibacterial mouthwash and preparation method thereof |
| CN113702559A (en) * | 2021-08-16 | 2021-11-26 | 江南大学 | Method for separating and identifying active substances of lactobacillus plantarum source inhibiting double-bacterium biological membrane |
| CN115429734A (en) * | 2021-10-28 | 2022-12-06 | 斯钦 | Mouthwash for diminishing inflammation and clearing internal heat and preparation method thereof |
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