RU2361600C1 - Agent for treatment of parodontium diseases - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention concerns stomatology area, and can be used for treatment of parodontium diseases. The agent for treatment of parodontium diseases as active substance of a phytogenesis contains a dry extract of leaves of a black currant, and also water, glycerin, water-soluble derivative of cellulose, calcium glycerophosphate, sodium fluoride, propyl paraben sodium salt, fructose, pepper mint oil.

EFFECT: expansion of assortment of the preparations applied to treatment of parodontium diseases, maintenance of mineralisation of teeth and cicatrisation of parodontal pockets, reduction of inflammatory phenomena in parodontium tissues.

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Description

The invention relates to medicine, namely dentistry, and can be used to treat periodontal disease.

Known compositions for the prevention and treatment of periodontal diseases in the form of toothpastes, rinses, elixirs, ointments containing traditional components - chlorhexidine, fluorides, minerals and additional extracts from medicinal plants. Hoods are presented in the form of CO ₂ extracts, water-alcohol, alcohol-glycerin extracts, as well as oils and decoctions.

Water-alcohol or water-alcohol-glycerol extracts used in the production of periodontitis treatment products contain an alcohol component that has a negative effect on the oral mucosa, especially if it is damaged.

Traditional in the treatment of periodontal diseases is the use of herbal preparations, such as: Salvin, Elekasol, decoction of oak bark, pine needles extracts, infusions of chamomile flowers, sage leaves, etc.

Known composition for the prevention of teeth and periodontal according to patent RU 2188626 from 09/10/2002, containing sodium fluoride or sodium monofluorophosphate, sodium carboxymethyl cellulose, sodium lauryl sulfate, titanium dioxide, sodium saccharinate, sorbitol or glycerin, silicon dioxide, food coloring, petroleum jelly, perfume water, chamomile extract, panthenol, calcium glycerophosphate, polyvinylpyrrolidone. The disadvantage of this composition is a weak anti-inflammatory and therapeutic effect.

It is known to use herbal decoctions as an aqueous medium for the manufacture of toothpaste and a toothpaste composition containing silicon dioxide, sorbitol, sodium carboxymethyl cellulose, sodium monofluorophosphate, sodium lauryl sulfate, a biologically active additive from a CO ₂ extract of plant material, softwood chlorophyll-carotene paste or Aloe-Vera extract and water-alcohol or water-alcohol-glycerin extract of plant materials, decoction of herbs, sodium saccharinate, preservative, color, flavor (patent RU 2306922 from 09.27.2007). This composition, containing a large number of ingredients, is very laborious in production and can cause allergic and other side effects due to the oversaturation of the constituent components.

The closest analogue is the composition for caring for the oral cavity according to patent RU 2272662 from 03/27/2006. The composition contains supercritical CO ₂ -extracts of young shoots of Siberian cedar, pine buds, needles of young shoots of juniper, as well as glycerin and / or sorbitol, silicon dioxide, sodium carboxymethyl cellulose and / or carbopol, sodium lauryl sulfate, preservative, sodium fluoride or sodium fluoride calcium gluconate or calcium glycerophosphate, saccharin or sodium saccharin, propylene glycol, titanium dioxide, dye, water. The disadvantages of the composition include the use of CO ₂ extracts, the production of which is very expensive. Toothpaste contains a large amount of abrasive component (silicon dioxide 5-25%), and the therapeutic effect of the composition on the oral cavity is short-lived.

In the case of treatment of periodontal diseases, it is necessary to keep the drug close to the affected areas surrounding the teeth in order to facilitate the diffusion of the active substances to the affected area.

The objective of the invention is to expand the range of tools used to treat periodontal disease.

To solve this problem, a tool is proposed that contains the following components: glycerol 5.0-7.0, hydroxyethyl cellulose 1.5-2.0, calcium glycerophosphate 1.0-1.1, sodium fluoride 0.24-0.3, dry blackcurrant leaf extract 0.4-0.5, fructose 0.05-0.2, propyl paraben sodium salt 0.2-0.3, peppermint oil 0.005-0.05, water up to 100.

The main difference of the proposed product is that the product contains an extract of blackcurrant leaves. Blackcurrant leaf extract is a source of polyphenolic substances - flavonoids, phenolcarboxylic acids, tannins, which provide bactericidal, antioxidant, capillary-strengthening and anti-inflammatory effects.

Another feature of the claimed funds is that it contains a dry lyophilized extract of blackcurrant leaves. Dry lyophilized extract of blackcurrant leaves is obtained by maceration of crushed raw materials with 70% ethanol under certain conditions, followed by freeze drying.

Glycerin is included in the composition for dissolving peppermint oil and for softening the mucous membranes of the oral cavity, maintaining the necessary viscosity.

Calcium glycerophosphate is a source of phosphorus and calcium in the teeth and periodontal tissues, which accelerates the processes of mineralization and increases the anti-carious effect of the drug.

Sodium fluoride provides an anti-caries effect and stimulates the mineralization of tooth tissues.

A water-soluble cellulose derivative, hydroxyethyl cellulose, has been introduced into the product to give it a gel-like consistency and prolonging properties.

Peppermint oil is introduced into the product as an aromatic additive and to improve organoleptic characteristics.

The proposed tool as a sweetener contains a sweetener fructose, thereby allowing the use of the tool for patients with diabetes mellitus.

Brief technology of obtaining funds for the treatment of periodontal diseases.

Example 1

60.0 purified water is heated to 50 ° C, 0.5 dry blackcurrant leaf extract, 0.3 sodium fluoride, 0.2 fructose, 0.3 propyl paraben sodium salt are added, stirred until complete dissolution and 2.0 hydroxyethyl cellulose is added, mix vigorously for an hour, add 7.0 glycerol, to which 1.1 calcium of glycerophosphate is added and 0.05 peppermint oil is previously dissolved, mix and bring the volume to 100.0 with purified water, mix until a homogeneous mass is formed.

Example 2

60.0 purified water is heated to 50 ° C, 0.4 dry blackcurrant leaf extract, 0.24 sodium fluoride, 0.05 fructose, 0.2 propyl paraben sodium salt are added, mixed until complete dissolution, and 1.5 hydroxyethyl cellulose is added, vigorously stirred for an hour, added 5.0 glycerol, to which 1.0 calcium glycerophosphate was added and 0.005 peppermint oil was previously dissolved, mixed and the volume was adjusted to 100.0 with purified water, mixed to form a homogeneous mass.

To evaluate the therapeutic effect of the claimed drug, tests were conducted on the basis of the Federal State Healthcare Institution of the Central Medical Unit No. 119 of the Federal Medical and Biological Agency of Russia of Medical Unit No. 4. The drug was used to treat acute and chronic diseases of the periodontium and oral mucosa in patients on outpatient treatment.

Depending on the treatment method, patients aged 25 to 40 years of both sexes were divided into the main group (10 people) and the control group (10 people).

For an objective assessment of the periodontal condition, the following indicators were determined: hygiene index (IG) and periodontal index (PI).

IG was evaluated by the intensity of staining of plaque of the vestibular surfaces of the six lower frontal (41, 42, 43, 31, 32, 33) teeth on a five-point scale. IG, reaching two or more points, indicated the absence of regular oral care. Dental staining was performed with Schiller-Pisarev solution (Kuryakina N.V., Kutepova T.F. Periodontal disease. - M.: Medical book, 2003. - 162 p.).

To assess the condition of periodontal tissues, a periodontal index (PI) was used. The assessment was based not only on gingival inflammation, but also on the presence of periodontal pockets and their depth, resorption of the alveolar bone and tooth statics. The value of the index from 0.1 to 1.0 indicates the initial and mild degree of periodontal pathology; from 1.0 to 4.0 - about the expressed stage; from 4.0 to 8.0 - about a severe form of periodontal lesions.

Clinical indicators characterizing the periodontal condition before treatment are presented in table 1, after treatment, in table 2.

Table 1 Clinical characteristics of patients of the main and control groups before treatment Indicators The main group (the claimed composition) Control group (known composition) Mucous membrane color Dark red with hyperemic Dark red with hyperemic marginal gingival margin plots plots The presence of a violation of the pattern of the gingival margin Broken Broken Gum bleeding Persistent bleeding Persistent bleeding

table 2 Clinical characteristics of patients in the main and control groups after treatment Indicators Main group Control group The color of the mucous membrane of the marginal gingival margin Pale pink Red with individual hyperemic areas The presence of swelling and hyperemia of the mucous membrane of the interdental papilla Absent Slight swelling The presence of a violation of the pattern of the gingival margin No violations Broken Condition of Gingival Pockets No pockets 1 mm pockets Gum bleeding Absent Slight bleeding

The analyzed claimed and known funds were used in the form of applications on the affected area. The treatment period was 10-11 days.

Clinical effects in the main group appeared 2-3 days after the start of treatment and resulted in a quick relief of signs of inflammation, early scarring of periodontal pockets, stopping bleeding of the gums after 4 days, eliminating tooth mobility of the first degree and reducing the second after 11 days. In patients of the control group, the clinical effect was observed after 2 weeks.

Changes in index indicators in patients of the main and control groups before and after treatment are presented in table 3.

Table 3 Comparative characteristics of the effectiveness of the claimed and known compositions according to index indicators Patient group IG indicator PI indicator The main group (the claimed composition) before treatment 2.20 ± 0.1 2.10 ± 0.05 The main group after treatment (after 4 weeks) 1,06 ± 0,05 0.14 ± 0.02 Control group (known composition) before treatment 2.25 ± 0.1 2.10 ± 0.05 The control group after treatment (after 4 weeks) 1.30 ± 0.05 0.17 ± 0.02

Thus, the claimed tool expands the arsenal of funds for the treatment of periodontal disease, is effective and safe. Clinical observations indicate high anti-inflammatory, wound healing and antimicrobial properties of the claimed drug, good tolerance and the absence of toxic and allergic reactions. The tool saturates the teeth with mineral components, helps to reduce the microbial load on the periodontal tissue.

Claims (1)

An agent for the treatment of periodontal diseases, including dry extract of blackcurrant leaves, glycerin, hydroxyethyl cellulose, calcium glycerophosphate, sodium fluoride, propyl paraben sodium salt, fructose, peppermint oil and purified water with the following components, wt.%:
dry blackcurrant leaf extract 0.4-0.5 glycerol 5.0-7.0 hydroxyethyl cellulose 1.5-2.0 calcium glycerophosphate 1.0-1.1 sodium fluoride 0.24-0.3 fructose 0.05-0.2 peppermint oil 0.005-0.05 propyl paraben sodium 0.2-0.3 purified water up to 100.0