CN111686021A - Toothpaste for relieving dentin sensitivity - Google Patents
Toothpaste for relieving dentin sensitivity Download PDFInfo
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- CN111686021A CN111686021A CN202010731741.2A CN202010731741A CN111686021A CN 111686021 A CN111686021 A CN 111686021A CN 202010731741 A CN202010731741 A CN 202010731741A CN 111686021 A CN111686021 A CN 111686021A
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- toothpaste
- hydroxyapatite
- paeonol
- potassium citrate
- clove oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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Abstract
The invention discloses toothpaste for relieving dentin sensitivity, which comprises an abrasive, a humectant, a thickening agent, a foaming agent, a sweetening agent, essence, a preservative and water, and also comprises 8-16% of an anti-sensitivity component, wherein the anti-sensitivity component comprises 16-28% of paeonol, 31-56% of clove oil, 11-16% of hydroxyapatite and 17-26% of potassium citrate. The toothpaste for relieving dentin sensitivity is scientific and safe, and can effectively relieve the dentin sensitivity and repair teeth.
Description
Technical Field
The invention relates to the technical field of toothpaste, in particular to toothpaste for relieving dentin sensitivity.
Background
Tooth sensitivity is commonly called as "tooth inversion", also known as dentine hypersensitivity or tooth root sensitivity, and refers to the symptoms of abnormal acidity, softness and pain of teeth when the teeth are subjected to external stimuli such as temperature, chemistry, machinery and the like. Dentinal hypersensitivity occurs in connection with the flow of open dentinal tubules and irritation and inflammation of the pulp or tubule nerves or cytoplasm. The long-term trouble of tooth sensitivity affects the daily life quality of people.
At present, some patients close dentinal tubules by means of operation to block external stimulation, but some patients tend to use simple and convenient methods, such as tooth brushing, mouth rinsing, smearing and the like, to effectively relieve sensitive symptoms of teeth. Wherein, the application of the toothpaste is the simplest and most convenient, and the toothpaste is most in line with economic benefits.
Disclosure of Invention
The invention aims to provide toothpaste for relieving dentin sensitivity, which is scientific and safe, and can effectively relieve the tooth sensitivity and repair teeth.
In order to achieve the purpose, the invention provides toothpaste for relieving dentin sensitivity, which comprises an abrasive, a humectant, a thickening agent, a foaming agent, a sweetening agent, essence, a preservative and water, and also comprises 8-16% of an anti-sensitivity component, wherein the anti-sensitivity component comprises 16-28% of paeonol, 31-56% of clove oil, 11-16% of hydroxyapatite and 17-26% of potassium citrate.
Preferably, the anti-allergic ingredient comprises 17% paeonol, 48% clove oil, 14% hydroxyapatite and 21% potassium citrate.
Preferably, the anti-allergic ingredient comprises 21% paeonol, 50% clove oil, 11% hydroxyapatite and 18% potassium citrate.
Preferably, the anti-allergic ingredient comprises 28% paeonol, 32% clove oil, 16% hydroxyapatite and 24% potassium citrate.
A preparation method of toothpaste for relieving dentin sensitivity comprises the following steps:
s1, putting the weighed thickener, clove oil and paeonol into a powder bin together, and uniformly stirring to form an oily solution;
s2, putting the weighed sweetener, the preservative, the potassium citrate and the hydroxyapatite into a premixing tank, adding the humectant and the water, fully dissolving, and sucking into a paste making machine;
s3, sucking the solution prepared in the step S1 into a paste making machine, and quickly stirring the solution until the solution is uniform;
s4, sucking the foaming agent and the abrasive into a paste making machine, and quickly stirring the mixture until the mixture is uniform after the powder is fed;
s5, slowly sucking essence, rapidly stirring under vacuum to uniform, mixing for 16-21min, degassing, standing, filtering, and sterilizing to obtain toothpaste.
Therefore, the toothpaste for relieving dentin hypersensitivity is scientific and safe, and can effectively relieve the dentin hypersensitivity and repair teeth. Cortex moutan extract acts on dentin nerve endings to relieve pain; clove oil is antiseptic, antibacterial and analgesic, and can be used for preventing oral diseases and inflammation. Meanwhile, potassium ions in the potassium citrate act on nerve endings of dentinal tubules after being released, the repolarization of nerve fibers is inhibited, the excitability of the nerve fibers is reduced, the conduction of nerve cells to pain signals is interfered, the sensitivity of teeth is relieved, meanwhile, the calcification degree of dentin is obviously improved, the formation of reparative dentin is promoted, and potassium salt crystals block the dentinal tubules to isolate external stimulation. In addition, the hydroxyapatite closes dentinal tubules, relieves the sensitivity of teeth to cold, heat, acid and sweet caused by nerve stimulation, relieves or even disappears the tooth sensitivity symptom, and can fundamentally prevent and relieve the oral problems of tooth sensitivity, antibiosis, antiphlogosis and the like.
The technical solution of the present invention is further described in detail by the following examples.
Detailed Description
The embodiments of the present invention will be further explained below.
A toothpaste for relieving dentin sensitivity comprises abrasive, humectant, thickener, foaming agent, sweetener, essence, antiseptic and water, and also comprises 8-16% of anti-sensitivity component, wherein the anti-sensitivity component comprises 16-28% of paeonol, 31-56% of oleum Caryophylli, 11-16% of hydroxyapatite and 17-26% of potassium citrate.
A preparation method of toothpaste for relieving dentin sensitivity comprises the following steps:
s1, putting the weighed thickener, clove oil and paeonol into a powder bin together, and uniformly stirring to form an oily solution;
s2, putting the weighed sweetener, the preservative, the potassium citrate and the hydroxyapatite into a premixing tank, adding the humectant and the water, fully dissolving, and sucking into a paste making machine;
s3, sucking the solution prepared in the step S1 into a paste making machine, and quickly stirring the solution until the solution is uniform;
s4, sucking the foaming agent and the abrasive into a paste making machine, and quickly stirring the mixture until the mixture is uniform after the powder is fed;
s5, slowly sucking essence, rapidly stirring under vacuum to uniform, mixing for 16-21min, degassing, standing, filtering, and sterilizing to obtain toothpaste.
Example one
The anti-allergic component comprises 17% of paeonol, 48% of clove oil, 14% of hydroxyapatite and 21% of potassium citrate.
Example two
The anti-allergic component comprises 21% of paeonol, 50% of clove oil, 11% of hydroxyapatite and 18% of potassium citrate.
EXAMPLE III
The anti-allergic component comprises 28% of paeonol, 32% of clove oil, 16% of hydroxyapatite and 24% of potassium citrate.
Test of
(1) Test method
Clinically, 100 subjects between 18 and 65 years old are selected, the subjects have at least 2 sensitive teeth and are randomly divided into 2 groups, the control group uses the common antiallergic toothpaste, and the test group uses the toothpaste prepared in the first example, then brushes the teeth twice a day for 8 weeks, and then the investigation is carried out. The evaluation was carried out by mechanical stimulation and temperature test, and the results are shown in the following table.
Wherein, the mechanical stimulation: the sensitive part of the tooth is lightly scratched by a probe to judge.
Temperature test: mouth rinse tests were performed with purified water at 15 ℃.
The evaluation criteria are all 0-no discomfort; 1 ═ mild discomfort or pain; 2-moderate pain; 3-severe pain and persistent.
Group of | No discomfort | Mild discomfort | Moderate pain | Severe pain |
Control group | 18 | 24 | 6 | 2 |
Test group | 38 | 9 | 2 | 0 |
The results show that the toothpaste of the invention has a remarkable effect on relieving dentin hypersensitivity.
Therefore, the toothpaste for relieving dentin hypersensitivity is scientific and safe, and can effectively relieve the dentin hypersensitivity and repair teeth.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that modifications can be made by those skilled in the art without departing from the principle of the present invention, and these modifications should also be construed as the protection scope of the present invention.
Claims (5)
1. A toothpaste for relieving dentin hypersensitivity, which is characterized in that: the toothpaste comprises an abrasive, a humectant, a thickening agent, a foaming agent, a sweetening agent, essence, a preservative and water, and also comprises 8-16% of an anti-allergy component, wherein the anti-allergy component comprises 16-28% of paeonol, 31-56% of clove oil, 11-16% of hydroxyapatite and 17-26% of potassium citrate.
2. The toothpaste according to claim 1, wherein said toothpaste is characterized by: the anti-allergic component comprises 17% of paeonol, 48% of clove oil, 14% of hydroxyapatite and 21% of potassium citrate.
3. The toothpaste according to claim 1, wherein said toothpaste is characterized by: the anti-allergic component comprises 21% of paeonol, 50% of clove oil, 11% of hydroxyapatite and 18% of potassium citrate.
4. The toothpaste according to claim 1, wherein said toothpaste is characterized by: the anti-allergic component comprises 28% of paeonol, 32% of clove oil, 16% of hydroxyapatite and 24% of potassium citrate.
5. A method of preparing a toothpaste for relieving dentinal sensitivity according to any of claims 1 to 4 by the steps of:
s1, putting the weighed thickener, clove oil and paeonol into a powder bin together, and uniformly stirring to form an oily solution;
s2, putting the weighed sweetener, the preservative, the potassium citrate and the hydroxyapatite into a premixing tank, adding the humectant and the water, fully dissolving, and sucking into a paste making machine;
s3, sucking the solution prepared in the step S1 into a paste making machine, and quickly stirring the solution until the solution is uniform;
s4, sucking the foaming agent and the abrasive into a paste making machine, and quickly stirring the mixture until the mixture is uniform after the powder is fed;
s5, slowly sucking essence, rapidly stirring under vacuum to uniform, mixing for 16-21min, degassing, standing, filtering, and sterilizing to obtain toothpaste.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202010731741.2A CN111686021A (en) | 2020-07-27 | 2020-07-27 | Toothpaste for relieving dentin sensitivity |
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CN202010731741.2A CN111686021A (en) | 2020-07-27 | 2020-07-27 | Toothpaste for relieving dentin sensitivity |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102860971A (en) * | 2012-09-19 | 2013-01-09 | 江苏江大源生态生物科技有限公司 | Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof |
CN104188855A (en) * | 2014-08-20 | 2014-12-10 | 广州立白企业集团有限公司 | Traditional Chinese medicine toothpaste with effects of preventing and relieving tooth sensitivity |
CN107811890A (en) * | 2017-10-31 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | A kind of oral cavity caring toothpaste composition |
CN109010240A (en) * | 2018-10-25 | 2018-12-18 | 大连丹特生物技术有限公司 | A kind of Pharmaceutical composition and its preparation method and application for alleviating sensitivity of tooth |
-
2020
- 2020-07-27 CN CN202010731741.2A patent/CN111686021A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102860971A (en) * | 2012-09-19 | 2013-01-09 | 江苏江大源生态生物科技有限公司 | Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof |
CN104188855A (en) * | 2014-08-20 | 2014-12-10 | 广州立白企业集团有限公司 | Traditional Chinese medicine toothpaste with effects of preventing and relieving tooth sensitivity |
CN107811890A (en) * | 2017-10-31 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | A kind of oral cavity caring toothpaste composition |
CN109010240A (en) * | 2018-10-25 | 2018-12-18 | 大连丹特生物技术有限公司 | A kind of Pharmaceutical composition and its preparation method and application for alleviating sensitivity of tooth |
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