CN109010240A - A kind of Pharmaceutical composition and its preparation method and application for alleviating sensitivity of tooth - Google Patents
A kind of Pharmaceutical composition and its preparation method and application for alleviating sensitivity of tooth Download PDFInfo
- Publication number
- CN109010240A CN109010240A CN201811252059.4A CN201811252059A CN109010240A CN 109010240 A CN109010240 A CN 109010240A CN 201811252059 A CN201811252059 A CN 201811252059A CN 109010240 A CN109010240 A CN 109010240A
- Authority
- CN
- China
- Prior art keywords
- tooth
- sensitivity
- pharmaceutical composition
- sodium
- alleviating
- Prior art date
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- 230000035945 sensitivity Effects 0.000 title claims abstract description 47
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
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- 239000001508 potassium citrate Substances 0.000 claims abstract description 16
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims abstract description 16
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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Abstract
The present invention relates to a kind of Pharmaceutical compositions and its preparation method and application for alleviating sensitivity of tooth, belong to food, health care product, Chinese herbal product and household chemicals technical field.The Pharmaceutical composition of the present invention for alleviating sensitivity of tooth includes xylitol, Chinese gall, eugenol, potassium citrate.The Chinese gall for having effects that bacteriostasis efficacy is hindered the potassium citrate of nerve conduction effect to share by the present invention with the anesthesia Paeonol of tooth nerve, eugenol and with closing dentinal tubule, enhances fungistatic effect, while can improve sensitivity of tooth.
Description
Technical field
The present invention relates to a kind of Pharmaceutical compositions and its preparation method and application for alleviating sensitivity of tooth, belong to food, protect
Strong product, Chinese herbal product and household chemicals technical field.
Background technique
Sensitivity of tooth refers to that tooth can be generated feeling of aching by after the stimulation such as hot and cold, sour, sweet tea, mechanism suddenly, or
Flash across or of short duration lasting, after stimulating removal, it is this ache sympathetic can disappear.
The factor of sensitivity of tooth is caused to specifically include that age factor, tooth wear degree, gum disease, injury of teeth etc.,
Main cause is that the damage of dental surface causes dentinal tubule exposed or bacterial invasion leads to tooth inflammation, and it is quick to cause tooth
Sense.According to Hydrodynamics Theory, effectively to treat hypersensitive dentin, on the one hand can by closing dentinal tubule to reduce or
The liquid in dentine is avoided to flow, to make desensitizing dental；On the other hand it can also pass through paralysis Intradental nerve, reduction tooth
Susceptibility, realize desensitization purpose.
Summary of the invention
The present invention is compounded by xylitol, Chinese gall, eugenol with potassium citrate, and the composition after making compounding has slow
The function of solving sensitivity of tooth, solves the above problem.
The present invention provides a kind of Pharmaceutical composition for alleviating sensitivity of tooth, the Pharmaceutical composition for alleviating sensitivity of tooth
Including xylitol, Chinese gall, eugenol, potassium citrate.
Xylitol of the present invention itself has biocidal property, it is edible do not generate decayed tooth, metabolism does not need insulin participation, be
Good carbohydrate substitute, and xylitol and effect component share and can play the role of enhancing drug effect.
Contain in Chinese gall of the present invention there are many alkaloid, tannin and volatile oil, there is anti-inflammatory analgetic and slight local anaesthesia
Effect, can reduce the susceptibility of dentine Yu Intradental nerve tip；Wherein tannin astriction is strong, can make in dentinal tubule
Protein coagulating, gradually close dentinal tubule, benumb nerve endings, mitigate pain, in addition volatile oil also have mild analgesic,
Paralysis nerve and anti-inflammatory analgesic effect, the conduction neural from blocking dentinal tubule of these important active substances and paralysis dental pulp
Two aspect of nerve realizes treatment hypersensitive dentin.
Eugenol of the present invention to staphylococcus aureus, Escherichia coli, bacillus subtilis, pseudomonas aeruginosa,
Aspergillus niger, Candida albicans, porphyromonas gingivalis, Streptococcus mutans, Fusobacterium nucleatum, lactobacillus acidophilus all have preferably
Inhibitory effect, the eugenol of low dosage can inhibit nerve ending activity, generates topical pain relief and anaesthetic effect.
The nerve endings that dentinal tubule is acted on after potassium ion release in potassium citrate of the present invention, inhibits nerve
The repolarization of fiber reduces the excitability of nerve fibre, conduction of the nerve cell to pain signal is interfered, to alleviate tooth
Sensitivity, meanwhile, dentine calcification degree can be made to significantly improve, promote Renovate dentin formation, sylvite crystallization obstruction dentine
Tubule and completely cut off environmental stimuli, potassium citrate can be used as acidity regulator in food, and it is appropriate according to production needs use, say
It is higher to be added to safety in oral care product for the edibility of bright potassium citrate.
The present invention is preferably that the Pharmaceutical composition for alleviating sensitivity of tooth is made of the following components by weight:
The present invention is preferably that the Pharmaceutical composition for alleviating sensitivity of tooth includes xylitol, Chinese gall, eugenol, lemon
Sour potassium, Paeonol.
Paeonol bitter of the present invention, pungent, slightly cold, return heart, liver and kidney channel have clearing heat and cooling blood, the function of activating microcirculation and removing stasis medicinal
Effect is clinically mainly used for treating rheumatalgia, stomachache, eczema, allergic dermatitis, hypersensitive dentin etc., this chemistry of Paeonol
The permeability that ingredient can effectively inhibit hemodia district's groups to knit reduces the flowing of liquid in dentine, meanwhile, there are also apparent towns
Pain acts on, and can lower the susceptibility of dentine and Intradental nerve tip, ensure that effectively treatment dental hypersensitiveness in terms of two
Effect.
The present invention is preferably that the Pharmaceutical composition for alleviating sensitivity of tooth is made of the following components by weight:
Another object of the present invention is a kind of preparation method for the Pharmaceutical composition for providing above-mentioned alleviation sensitivity of tooth, the systems
Preparation Method are as follows: press predetermined weight part, xylitol, nutgall extractive, eugenol, potassium citrate, Paeonol are mixed, delayed
Solve the Pharmaceutical composition of sensitivity of tooth.
The present invention is preferably the nutgall extractive the preparation method comprises the following steps: gallnut extract is broken to 60-100 mesh, is placed in
0.5-3h, first 60-80 DEG C of refluxing extraction 1-3h, then ultrasonic extraction 10-30min are impregnated in water, vacuum drying obtains Chinese gall and mentions
Take object.
Another object of the present invention is to provide a kind of Pharmaceutical composition of above-mentioned alleviation sensitivity of tooth in food, health care product, medicine
Application in product and household chemicals.
The present invention is preferably that the Pharmaceutical composition for alleviating sensitivity of tooth is added in auxiliary material, and chewing gum, piece is made
Agent, toothpaste, mouthwash.
The present invention is preferably that the auxiliary material is sweetener, acidity regulator, thickener, emulsifier, essence, pigment, anti-corrosion
At least one of agent, moisturizer and foaming agent；The sweetener is sucrose, fructose, D-sorbite, maltitol, different malt
At least one of ketose alcohol, antierythrite, acesulfame potassium, Aspartame, steviol glycoside, Sucralose and starch；The acidity
Regulator be citric acid and its salt, malic acid and its salt, tartaric acid and its salt, glacial acetic acid, lactic acid and its salt, fumaric acid and its
At least one of salt, carbonate and bicarbonate；The thickener is guar gum, pectin, gloiopeltis glue, propylene glycol alginate
Ester, sodium alginate, locust bean gum, cyclodextrine, xanthan gum, polydextrose, cassia gum, carragheen, curdlan, soluble soybean
Polysaccharide, phosphorylation PASELLI EASYGEL, calcium chloride, tamarind seed polysaccharide glue, maltitol, pulullan polysaccharide, calcium lactate, biacetyl
At least one of tartaric acid list double glyceride, sodium carboxymethyl starch, sodium carboxymethylcellulose and Arabic gum；The emulsifier
It is double sweet for phosphatide, casein sodium, hydroxypropul starch, lactic acid fatty glyceride, starch Sodium Octenyl Succinate, acetylation list
Oil and fat acid esters, polysorbas20, polysorbate40, polysorbate60, Tween 80 and at least one of stearic acid and its magnesium salts；The preservative
For sorbic acid and its sylvite, benzoic acid and sodium benzoate, lysozyme, nisin, sodium Diacetate, sodium propionate, calcium propionate and
At least one of methyl hydroxybenzoate；The moisturizer is at least one of glycerol, propylene glycol and polyphosphate；The blistering
Agent is at least one of lauryl sodium sulfate, sodium lauroyl sarcosine and sodium cocoyl glycinate.
The invention has the following beneficial effects:
1. the present invention by the Chinese gall with bacteriostasis efficacy with have the anesthesia Paeonol of tooth nerve, eugenol and
It hinders the potassium citrate of nerve conduction effect to share with closing dentinal tubule, enhances fungistatic effect, while can improve
Sensitivity of tooth.
2. it is quick that the present invention by the reasonable compatibility of various traditional Chinese medicine ingredients, has reached fundamentally treatment tooth inflammation, tooth
The purpose of sense.
3. traditional anti-sensitive composition mainly uses strontium chloride or potassium nitrate, and have can for the potassium citrate that the present invention uses
Consumption, safety is higher compared with strontium chloride or potassium nitrate, is more suitable for oral-cavity article.
Specific embodiment
Following non-limiting embodiments can with a person of ordinary skill in the art will more fully understand the present invention, but not with
Any mode limits the present invention.
Embodiment 1
A kind of preparation method of Pharmaceutical composition that alleviating sensitivity of tooth, the preparation method comprises the following steps:
1. 30 parts of blocky gallnut extracts by weight, are broken to 100 mesh, it is placed in water and impregnates 1h, first 60 DEG C of refluxing extractions
2h, then ultrasonic extraction 30min, vacuum drying obtain nutgall extractive；
2. by weight, by 100 parts of xylitols, 6 parts of eugenols, 1 part of potassium citrate and step, 1. gained Chinese gall is extracted
Object mixes, the Pharmaceutical composition for the sensitivity of tooth that is eased, which can dip when brushing teeth uses together with toothpaste in right amount,
Achieve the effect that alleviate sensitivity of tooth.
Embodiment 2
A kind of preparation method of tablet that alleviating sensitivity of tooth, the preparation method comprises the following steps:
1. 50 parts of blocky gallnut extracts by weight, are broken to 100 mesh, it is placed in water and impregnates 3h, first 65 DEG C of refluxing extractions
2h, then ultrasonic extraction 20min, vacuum drying obtain nutgall extractive；
2. by weight, by 100 parts of xylitols, 3 parts of eugenols, 2 parts of potassium citrates, 3 parts of Paeonols and step 1. gained
Nutgall extractive mixes, and obtains Pharmaceutical composition；
3. by weight, by the step 40w/v% Arab peptization that 2. prepared by gained Pharmaceutical composition and 3 parts of Arabic gums
Liquid mixing granulation adds 1 part of magnesium stearate tabletting, the tablet for the sensitivity of tooth that is eased.
Embodiment 3
A kind of preparation method of mouthwash that alleviating sensitivity of tooth, the preparation method comprises the following steps:
1. 50 parts of blocky gallnut extracts by weight, are broken to 100 mesh, it is placed in water and impregnates 1h, first 70 DEG C of refluxing extractions
1h, then ultrasonic extraction 20min, vacuum drying obtain nutgall extractive；
2. by weight, by 100 parts of xylitols, 10 parts of eugenols, 5 parts of potassium citrates, 10 parts of Paeonols and step 1. institute
It obtains nutgall extractive to mix, obtains Pharmaceutical composition；
3. by step, 2. gained Pharmaceutical composition is dissolved in 500 parts of water, the mouthwash for the sensitivity of tooth that is eased.
Test case 1
Bacteriostatic test
Choose oral cavity common pathogen: streptococcus mutans, porphyromonas gingivalis are as test microbes.
Sample preparation:
It is 5mm that diameter, which is made, in the tablet of alleviation sensitivity of tooth prepared by embodiment 2, with a thickness of the disk of 4mm.
The inoculation of test organisms:
Drawing concentration is 5 × 105-5×106Cfu/mL tests bacteria suspension 1mL into sterilizes culture dish, pours into 15mL and has gone out
The culture medium of bacterium rotates culture dish, mixes culture medium and bacterium solution, standing congeals into plate；
Uniformly make a call to 4 holes clockwise on plate with 5mm punch, apart 25mm between each hole center, the week with plate
Edge takes out culture medium in hole at a distance of 15mm, with sterile tweezers, and 3 parts of test specimens and 1 are separately added into punched hole hole
Part negative control, using aseptic deionized water as negative control, the Pharmaceutical composition of alleviation sensitivity of tooth prepared by embodiment 1 is taken
0.2g is added in hole, and the tablet of alleviation sensitivity of tooth prepared by embodiment 2 is directly laid flat into hole, and embodiment 3 is prepared slow
The additive amount of the mouthwash and negative control that solve sensitivity of tooth is 0.2mL；
Plate is covered, sets 37 DEG C of incubators, culture 18h observation is as a result, with the diameter of vernier caliper measurement antibacterial ring size (including patch
Piece) and record；
When measuring antibacterial ring size, it should select uniformly and the antibacterial ring size progress of integral asepsis growth, measuring its diameter should be with antibacterial ring size
Outer is boundary.
Evaluation regulation
A, the judgement of bacteriostasis:
Inhibition zone diameter is greater than 7mm person, has been judged to bacteriostasis；
Inhibition zone diameter is less than or equal to 7mm person, is judged to no bacteriostasis；
B, 3 repetition tests have bacteriostasis result person, are judged to qualification；
C, negative control group should be generated without inhibition zone, and otherwise test is invalid.
Experimental result is shown in Table 1.
Table 1
Test case 2
The test of clinical remission sensitivity of tooth
100 patients for suffering from sensitivity of tooth are chosen, men and women is unlimited, is by age equally divided into 4 groups, and every group of 25 people use machine
Three kinds of tool stimulation, humid test and subjective assessment methods are evaluated, everyone at least detects 3 teeth.
Mechanical stimulus: the sensitive part of tooth is streaked gently with probe to judge.
Humid test: test of gargling is carried out with 15 DEG C of pure water.
Evaluation criterion:
Mechanical test:
0=is without discomfort；Uncomfortable or pain that 1=is slight；2=moderate pain；3=severe pain and continue；
Humid test:
0=is without discomfort；Uncomfortable or pain that 1=is slight；2=moderate pain；3=severe pain and continue；
Subjective assessment (VAS method):
1=improves；0=is without change；- 1=is aggravated.
The Pharmaceutical composition for the alleviation sensitivity of tooth that 1 use ordinary toothpaste of group is prepared with embodiment 1, which mixes, brushes teeth, and group 2 is every
It is using the tablet of the ordinary toothpaste alleviation sensitivity of tooth that after brushing deutostoma is prepared containing embodiment 2, and group 3 is daily using ordinary toothpaste
The mouthwash prepared with embodiment 3 for alleviating sensitivity of tooth is after brushing adopted afterwards containing 30s is gargled, control group is brushed teeth using ordinary toothpaste,
Ordinary toothpaste is that laboratory technician issues the unified commercially available toothpaste without antiallergic ingredient of every subject, and subject is required to brush daily
Tooth 2 times, each 3min continues 1 month, and experimental result is shown in Table 2.
Table 2
Claims (9)
1. a kind of Pharmaceutical composition for alleviating sensitivity of tooth, it is characterised in that: the Pharmaceutical composition packet for alleviating sensitivity of tooth
Include xylitol, Chinese gall, eugenol, potassium citrate.
2. alleviating the Pharmaceutical composition of sensitivity of tooth according to claim 1, it is characterised in that: the alleviation sensitivity of tooth
Pharmaceutical composition is made of the following components by weight:
3. alleviating the Pharmaceutical composition of sensitivity of tooth according to claim 2, it is characterised in that: the alleviation sensitivity of tooth
Pharmaceutical composition includes xylitol, Chinese gall, eugenol, potassium citrate, Paeonol.
4. alleviating the Pharmaceutical composition of sensitivity of tooth according to claim 3, it is characterised in that: the alleviation sensitivity of tooth
Pharmaceutical composition is made of the following components by weight:
5. the preparation method of claim 1,2,3 or 4 Pharmaceutical compositions for alleviating sensitivity of tooth, it is characterised in that: described
The preparation method comprises the following steps: pressing predetermined weight part, xylitol, nutgall extractive, eugenol, potassium citrate, Paeonol are mixed, obtained
Alleviate the Pharmaceutical composition of sensitivity of tooth.
6. preparation method according to claim 5, it is characterised in that: the nutgall extractive the preparation method comprises the following steps: will
Gallnut extract is broken to 60-100 mesh, is placed in water and impregnates 0.5-3h, first 60-80 DEG C of refluxing extraction 1-3h, then ultrasonic extraction 10-
30min, vacuum drying obtain nutgall extractive.
7. claim 1,2,3 or 4 Pharmaceutical compositions for alleviating sensitivity of tooth are in food, health care product, drug and dailyization
Application in product.
8. application according to claim 7, it is characterised in that: the Pharmaceutical composition for alleviating sensitivity of tooth to be added to
In auxiliary material, chewing gum, tablet, toothpaste, mouthwash is made.
9. application according to claim 8, it is characterised in that: the auxiliary material be sweetener, acidity regulator, thickener,
At least one of emulsifier, essence, pigment, preservative, moisturizer and foaming agent；
The sweetener is sucrose, fructose, D-sorbite, maltitol, isomalt, antierythrite, acesulfame potassium, A Si
At least one of Ba Tian, steviol glycoside, Sucralose and starch；
The acidity regulator be citric acid and its salt, malic acid and its salt, tartaric acid and its salt, glacial acetic acid, lactic acid and its salt,
At least one of fumaric acid and its salt, carbonate and bicarbonate；
The thickener is guar gum, pectin, gloiopeltis glue, propylene glycol alginate, sodium alginate, locust bean gum, cyclodextrine, Huang
Virgin rubber, polydextrose, cassia gum, carragheen, curdlan, soluble soybean polysaccharide, phosphorylation PASELLI EASYGEL, chlorination
Calcium, tamarind seed polysaccharide glue, maltitol, pulullan polysaccharide, calcium lactate, diacetyl tartaric acid monodiglyceride, carboxymethyl starch
At least one of sodium, sodium carboxymethylcellulose and Arabic gum；
The emulsifier is phosphatide, casein sodium, hydroxypropul starch, lactic acid fatty glyceride, octenyl succinic acid starch
In sodium, acetylation list diglycerine fatty acid ester, polysorbas20, polysorbate40, polysorbate60, Tween 80 and stearic acid and its magnesium salts at least
It is a kind of；
The preservative is sorbic acid and its sylvite, benzoic acid and sodium benzoate, lysozyme, nisin, sodium Diacetate, third
At least one of sour sodium, calcium propionate and methyl hydroxybenzoate；
The moisturizer is at least one of glycerol, propylene glycol and polyphosphate；
The foaming agent is at least one of lauryl sodium sulfate, sodium lauroyl sarcosine and sodium cocoyl glycinate.
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