CN107412041A - A kind of plant toothpaste of clearing heat and removing internal heat and preparation method thereof - Google Patents
A kind of plant toothpaste of clearing heat and removing internal heat and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention relates to oral care implement and field of toothpaste, more particularly to plant toothpaste of a kind of clearing heat and removing internal heat and preparation method thereof.Plant toothpaste of the present invention is made of NMF, rubbing agent, surfactant, freshener, Spilanthes oleracea extract, streblus asper leaf extract, Murraya jasminorage leaf extract, pine nut elecampane oil, wintergreen leaf oil, blue gum leaf oil, preservative, thickener, flavouring agent and water.Confirmed through clinical test, plant toothpaste of the present invention has preferable adjuvant treatment effect to canker sore, swelling and aching of gum etc. " excessive internal heat " class mouth disease, and the present invention is widely applicable, safe to use.
Description
Technical field
The present invention relates to the plant toothpaste and its system of oral care implement and field of toothpaste, more particularly to a kind of clearing heat and removing internal heat
Preparation Method.
Background technology
Oral health is extremely important to health, report display, the bad and many systemic disease of oral healthy condition,
As heart disease, diabetes, respiratory disease are closely related.Mouth disease, including decayed tooth, canker sore, bleeding gums, gum
Including inflammation, periodontitis, gingival atrophy and bone-loss, it is considered as the third-largest killer of human health.Therefore, exploitation effectively prevention
And the new method for treating mouth disease has important practical significance.
Toothpaste is indispensable oral care implement in people's daily life, and its basic function is to clean tooth, clear
New implication, keep oral hygiene.In recent years, the development with science and technology with the improvement of living standards, consumer healthcare's consciousness
Constantly enhancing, it is also proposed more requirements, single cleaning toothpaste can not meet that different levels disappear to the function of toothpaste
The needs of the person of expense, corresponding, some can aid in preventing mouth disease, the functional form with oral care health-care effect
Tooth paste product arises at the historic moment, for example, patent of invention 201410199666.4 " a kind of Chinese herbal toothpaste of anti-inflammation hemostasia " discloses
One kind is by Baical Skullcap root P.E, Pudilan extract, polyethylene glycol, glycerine, sorbierite, xanthans, sodium carboxymethylcellulose, sugar
Essence, lauryl sodium sulfate, dioxide/silica gel, essence, soluble propylhydroxybenzoate, nipabutyl sodium, sodium hydroxide and water are made
Chinese herbal toothpaste, have anti-inflammation hemostasia auxiliary treatment functio.
Canker sore is commonly called as " aphtha ", is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, is more common in
The positions such as lip inner side, tongue, tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate.Sharp ache when canker sore is broken out, local cusalgia are bright
Aobvious, severe patient can also influence diet, speak, and very big inconvenience is caused to daily life.Canker sore is that many factors are comprehensive
The result of cooperation, including local trauma, stress, food, medicine, malnutrition, hormonal readiness change, vitamin or micro-
Secondary element shortage etc..
The traditional Chinese medical science thinks, canker sore be due to yin-Yang it is unbalance and caused by " excessive internal heat ", its pathogenic factor is mostly outside heat toxin
Invade, part of the body cavity above the diaphragm housing the heart and lungs intrinsic heat causes deficiency of Yin breakdown of the normal physiological coordination between the heart and the kidney, excessive fire in heart.After diseases caused by external factors heat toxin, the rotten to the corn raw sore in the normal dispute many places of patient, sore is flushing
Swollen, scorching hot pain, very then halitosis, swelling and aching of gum, or with symptoms such as thirsty more drink, yellow urine constipation, red tongue with yellowish fur, slippery and rapid pulses.It is more
Using heat-clearing, purging intense heat, antidote prescription therapeutic.
At present, researcher, which has developed some, has heat-clearing toxin-expelling functions, is burst available for auxiliary treatment oral cavity
The functional form Chinese herbal toothpaste of the oral cavities such as ulcer, swelling and aching of gum " excessive internal heat " class disease.For example, patent of invention 201410387393.6
" swollen sterilization adult toothpaste is removed in a kind of anti-inflammatory " disclose it is a kind of relieved the pain with anti-inflammatory, hemostasis of subsiding a swelling, heat-clearing solution fire biocidal efficacies
Toothpaste, it is to be made up of rubbing agent, NMF, adhesion agent, foaming agent, Chinese medicine extractant, sweetener, auxiliary agent and water, in therein
Medicine extractant is by the red sage root, radix scutellariae, honeysuckle, gingko, lotus leaf, rheum officinale, Asiatic plantain, dandelion, wormwood, Chloranthus glaber, pseudo-ginseng, the bletilla striata
It is made, auxiliary agent is made up of hydrogen peroxide, green tea powder and aloe extract.
However, in place of existing antipyretic and antidotal type Chinese herbal toothpaste still has some shortcomings, for example, in the prescription of this kind of toothpaste
More containing cool nature medicine things such as rheum officinale, honeysuckles, the patient for being not appropriate for the constitution cold of insufficiency type is long-term use of；Some toothpaste contain numerous
Traditional Chinese medicine ingredients, complex manufacturing, quality control difficulty are big；There are some Chinese herbal toothpastes to work relatively slow and curative effect not in addition
Definitely, improper use can also cause the new oral problem such as sensitivity of tooth.Therefore, be badly in need of in the market it is a kind of it is widely applicable,
Relatively easy, evident in efficacy, the safe to use plant health toothpaste of composition.
The content of the invention
The invention provides a kind of widely applicable, curative for effect plant toothpaste and oral care plant composition.
The first aspect of the present invention, there is provided a kind of plant toothpaste of clearing heat and removing internal heat, it is the raw material by following weight parts
It is manufactured：
NMF 30-35, rubbing agent 27-36, surfactant 1.6-2.0, freshener 0.2-0.5, Spilanthes oleracea extract
2.5-3.0, streblus asper leaf extract 4.2-5.0, Murraya jasminorage leaf extract 3.2-3.6, pine nut elecampane oil 4.0-4.5, white pearl of tiling
Leaf oil 1.8-2.2, blue gum leaf oil 2.6-3.0, preservative 0.1-0.2, thickener 0.6-1.0, flavouring agent 0.9-1.2, water 20-
24；
This plant toothpaste is made by following steps：
Will streblus asper leaf is dry, crush after add 8-10 times and measure 30% ethanol, refluxing extraction 1 hour, medicine after immersion 2 hours
Liquid is filtered, and filtrate is standby, and 8 times of amount petroleum ethers are then added into filter residue：Ethyl acetate=5：1 mixed solvent, refluxing extraction 1 are small
When, filtering, merging filtrate, it is spray-dried after being concentrated under reduced pressure into small size, obtains streblus asper leaf extract；
8 times of amount ethanol will be added after Spilanthes oleracea drying, crushing：Ethyl acetate=3：1 mixed solvent, immersion are returned after 2 hours
Stream extraction 1 hour, decoction filtration, filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, subtracted
Pressure is spray-dried after being concentrated into small size, obtains Spilanthes oleracea extract；
Will Murraya jasminorage leaf is dry, crush after add 8-10 times and measure 60% ethanol, refluxing extraction 1 hour, medicine after immersion 2 hours
Liquid is filtered, and filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, are concentrated under reduced pressure into small size
After be spray-dried, obtain Murraya jasminorage leaf extract；
First above-mentioned NMF, rubbing agent, thickener and the suitable quantity of water of formula ratio are added in vacuum Manufacturing medicine extract machine, it is fully mixed
It is even；Again by surfactant, freshener, preservative, flavouring agent, pine nut elecampane oil, wintergreen leaf oil, blue gum leaf oil and appropriate
Water is added in vacuum Manufacturing medicine extract machine, is fully mixed；Streblus asper leaf extract, Spilanthes oleracea extract, Murraya jasminorage leaf is eventually adding to carry
Thing and suitable quantity of water are taken, the fully emulsified mixing of high-speed stirred, produces this plant toothpaste.
The parts by weight of above-mentioned raw materials are preferred：
NMF 30, rubbing agent 27, surfactant 1.6, freshener 0.2, Spilanthes oleracea extract 2.5, streblus asper leaf carry
Take thing 4.2, Murraya jasminorage leaf extract 3.2, pine nut elecampane oil 4.0, wintergreen leaf oil 1.8, blue gum leaf oil 2.6, preservative
0.1, thickener 0.6, flavouring agent 0.9, water 20.
The parts by weight of above-mentioned raw materials are further preferably：
NMF 32, rubbing agent 32, surfactant 1.8, freshener 0.3, Spilanthes oleracea extract 2.8, streblus asper leaf carry
Take thing 4.5, Murraya jasminorage leaf extract 3.5, pine nut elecampane oil 4.2, wintergreen leaf oil 2.0, blue gum leaf oil 2.8, preservative
0.15, thickener 0.8, flavouring agent 1.0, water 22.
The parts by weight of above-mentioned raw materials are further preferably：
NMF 35, rubbing agent 36, surfactant 2.0, freshener 0.5, Spilanthes oleracea extract 3.0, streblus asper leaf carry
Take thing 5.0, Murraya jasminorage leaf extract 3.6, pine nut elecampane oil 4.5, wintergreen leaf oil 2.2, blue gum leaf oil 3.0, preservative
0.2, thickener 1.0, flavouring agent 1.2, water 24.
Further, the plant toothpaste of clearing heat and removing internal heat of the present invention, in its composition of raw materials：
The NMF is one or more of compositions in sorbierite, glycerine, propane diols, polyethylene glycol；
The rubbing agent is calcium phosphate dibasic dihydrate, hydrated silica, calcium carbonate, aluminium hydroxide, calcium pyrophosphate, anhydrous phosphoric acid
One or more of compositions in hydrogen calcium；
The surfactant is one kind in sldium lauryl sulfate, laurilsulfate sodium, sodium lauroyl sarcosine
Or several composition；
The thickener is sodium carboxymethylcellulose, xanthans, carragheen, guar gum, one kind in deer horn pectin or several
The composition of kind；
The freshener is menthol；
The preservative is one or more of compositions in potassium sorbate, sodium benzoate；
The flavouring agent is one or more of compositions in Mint Essence, fruit essence, plants essential oil.
The second aspect of the present invention, there is provided a kind of oral care plant composition, it is the raw material by following weight parts
It is manufactured：
Spilanthes oleracea extract 2.5-3.0, streblus asper leaf extract 4.2-5.0, Murraya jasminorage leaf extract 3.2-3.6；
This plant composition is made by following steps：
Will streblus asper leaf is dry, crush after add 8-10 times and measure 30% ethanol, refluxing extraction 1 hour, medicine after immersion 2 hours
Liquid is filtered, and filtrate is standby, and 8 times of amount petroleum ethers are then added into filter residue：Ethyl acetate=5：1 mixed solvent, refluxing extraction 1 are small
When, filtering, merging filtrate, it is spray-dried after being concentrated under reduced pressure into small size, obtains streblus asper leaf extract；
8 times of amount ethanol will be added after Spilanthes oleracea drying, crushing：Ethyl acetate=3：1 mixed solvent, immersion are returned after 2 hours
Stream extraction 1 hour, decoction filtration, filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, subtracted
Pressure is spray-dried after being concentrated into small size, obtains Spilanthes oleracea extract；
Will Murraya jasminorage leaf is dry, crush after add 8-10 times and measure 60% ethanol, refluxing extraction 1 hour, medicine after immersion 2 hours
Liquid is filtered, and filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, are concentrated under reduced pressure into small size
After be spray-dried, obtain Murraya jasminorage leaf extract；
Above-mentioned streblus asper leaf extract, Spilanthes oleracea extract, Murraya jasminorage leaf extract are well mixed, produce this plant group
Compound.
Further, the raw material that oral care plant composition of the present invention is made also includes following weight parts：
Pine nut elecampane oil 4.0-4.5, wintergreen leaf oil 1.8-2.2, blue gum leaf oil 2.6-3.0.
Preferably, the parts by weight of each raw material of oral care plant composition of the present invention, which are made, is：
Spilanthes oleracea extract 2.8, streblus asper leaf extract 4.5, Murraya jasminorage leaf extract 3.5, pine nut elecampane oil 4.2, tiling
Gaultheria leaf oil 2.0, blue gum leaf oil 2.8.
Moreover, it relates to above-mentioned oral care plant composition answering in following oral care implements are prepared
With：Creme, ointment, gel, foaming agent, pulvis, lozenge, collutory.
Through experiment, plant toothpaste of the present invention has preferable to " excessive internal heat " class such as canker sore, swelling and aching of gum mouth disease
Adjuvant treatment effect, and the present invention is widely applicable, safe to use, is especially suitable for the current market demand.
Embodiment
Illustrate embodiments of the present invention below by way of specific instantiation, those skilled in the art can be by this specification
Disclosed content understands other advantages and effect of the present invention easily.The present invention can also pass through specific realities different in addition
The mode of applying is embodied or practiced, the various details in this specification can also be based on different viewpoints with application, without departing from
Various modifications or alterations are carried out under the spirit of the present invention.
Before the specific embodiment of the invention is further described, it should be appreciated that protection scope of the present invention is not limited to down
State specific specific embodiment；It is also understood that the term used in the embodiment of the present invention is specific specific in order to describe
Embodiment, the protection domain being not intended to be limiting of the invention.
When embodiment provides number range, it should be appreciated that except non-invention is otherwise noted, two ends of each number range
Any one numerical value can be selected between point and two end points.Unless otherwise defined, in the present invention all technologies for using and
Scientific terminology is identical with the meaning that those skilled in the art of the present technique are generally understood that.Except used in embodiment specific method, equipment,
Outside material, according to grasp of the those skilled in the art to prior art and the record of the present invention, it can also use and this
Any method, equipment and the material of the similar or equivalent prior art of method, equipment described in inventive embodiments, material come real
The existing present invention.
The using effect of plant toothpaste of the present invention is described in detail below in conjunction with specific embodiment and comparative example.
Embodiment 1
A kind of plant toothpaste of clearing heat and removing internal heat, it is made of the raw material of following weight parts：
Sorbierite 32, calcium phosphate dibasic dihydrate 32, sldium lauryl sulfate 1.8, menthol 0.3, Spilanthes oleracea extract 2.8,
Streblus asper leaf extract 4.5, Murraya jasminorage leaf extract 3.5, pine nut elecampane oil 4.2, wintergreen leaf oil 2.0, blue gum leaf oil
2.8, sodium benzoate 0.15, xanthans 0.8, Mint Essence 1.0, water 22；
Preparation method is as follows：
Will streblus asper leaf is dry, crush after add 8-10 times and measure 30% ethanol, refluxing extraction 1 hour, medicine after immersion 2 hours
Liquid is filtered, and filtrate is standby, and 8 times of amount petroleum ethers are then added into filter residue：Ethyl acetate=5：1 mixed solvent, refluxing extraction 1 are small
When, filtering, merging filtrate, it is spray-dried after being concentrated under reduced pressure into small size, obtains streblus asper leaf extract；
8 times of amount ethanol will be added after Spilanthes oleracea drying, crushing：Ethyl acetate=3：1 mixed solvent, immersion are returned after 2 hours
Stream extraction 1 hour, decoction filtration, filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, subtracted
Pressure is spray-dried after being concentrated into small size, obtains Spilanthes oleracea extract；
Will Murraya jasminorage leaf is dry, crush after add 8-10 times and measure 60% ethanol, refluxing extraction 1 hour, medicine after immersion 2 hours
Liquid is filtered, and filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, are concentrated under reduced pressure into small size
After be spray-dried, obtain Murraya jasminorage leaf extract；
First the sorbierite of formula ratio, calcium phosphate dibasic dihydrate, xanthans and suitable quantity of water are added in vacuum Manufacturing medicine extract machine, filled
Divide and mix；Again by sldium lauryl sulfate, menthol, sodium benzoate, Mint Essence, pine nut elecampane oil, wintergreen leaf oil, blue gum
Leaf oil and suitable quantity of water are added in vacuum Manufacturing medicine extract machine, are fully mixed；It is eventually adding above-mentioned streblus asper leaf extract, Spilanthes oleracea extraction
Thing, Murraya jasminorage leaf extract and suitable quantity of water, the fully emulsified mixing of high-speed stirred, produce this plant toothpaste.
Embodiment 2
A kind of plant toothpaste of clearing heat and removing internal heat, it is made of the raw material of following weight parts：
Polyethylene glycol 30, hydrated silica 27, laurilsulfate sodium 1.6, menthol 0.2, Spilanthes oleracea extract 2.5,
Streblus asper leaf extract 4.2, Murraya jasminorage leaf extract 3.2, pine nut elecampane oil 4.0, wintergreen leaf oil 1.8, blue gum leaf oil
2.6, potassium sorbate 0.1, sodium carboxymethylcellulose 0.6, fruit essence 0.9, water 20；
Preparation method is as follows：
Streblus asper leaf extract, Spilanthes oleracea extract, the preparation method of Murraya jasminorage leaf extract are the same as embodiment 1；
The polyethylene glycol of formula ratio, hydrated silica, sodium carboxymethylcellulose and suitable quantity of water are first added to vacuum Manufacturing medicine extract machine
In, fully mix；Again by laurilsulfate sodium, menthol, potassium sorbate, fruit essence, pine nut elecampane oil, wintergreen
Leaf oil, blue gum leaf oil and suitable quantity of water are added in vacuum Manufacturing medicine extract machine, are fully mixed；Be eventually adding above-mentioned streblus asper leaf extract,
Spilanthes oleracea extract, Murraya jasminorage leaf extract and suitable quantity of water, the fully emulsified mixing of high-speed stirred, produce this plant toothpaste.
Embodiment 3
A kind of plant toothpaste of clearing heat and removing internal heat, it is made of the raw material of following weight parts：
Glycerine 20, propane diols 15, calcium pyrophosphate 24, aluminium hydroxide 12, sodium lauroyl sarcosine 2.0, menthol 0.5, thousand
Day chrysanthemum extract 3.0, streblus asper leaf extract 5.0, Murraya jasminorage leaf extract 3.6, pine nut elecampane oil 4.5, wintergreen leaf oil
2.2, blue gum leaf oil 3.0, sodium benzoate 0.2, carragheen 1.0, plants essential oil 1.2, water 24；
Preparation method is as follows：
Streblus asper leaf extract, Spilanthes oleracea extract, the preparation method of Murraya jasminorage leaf extract are the same as embodiment 1；
The glycerine of formula ratio, propane diols, calcium pyrophosphate, aluminium hydroxide, carragheen and suitable quantity of water are first added to vacuum system
In cream machine, fully mix；Again by sodium lauroyl sarcosine, menthol, sodium benzoate, plants essential oil, pine nut elecampane oil, the white pearl of tiling
Leaf oil, blue gum leaf oil and suitable quantity of water are added in vacuum Manufacturing medicine extract machine, are fully mixed；It is eventually adding above-mentioned streblus asper leaf extraction
Thing, Spilanthes oleracea extract, Murraya jasminorage leaf extract and suitable quantity of water, the fully emulsified mixing of high-speed stirred, produce this plant toothpaste.
Comparative example 1
A kind of plant toothpaste of clearing heat and removing internal heat, it is made of the raw material of following weight parts：
Sorbierite 32, calcium phosphate dibasic dihydrate 32, sldium lauryl sulfate 1.8, menthol 0.3, Spilanthes oleracea extract 2.8,
Streblus asper leaf extract 4.5, Murraya jasminorage leaf extract 3.5, pine nut elecampane oil 4.2, wintergreen leaf oil 2.0, blue gum leaf oil
2.8, sodium benzoate 0.15, xanthans 0.8, Mint Essence 1.0, water 22；
Preparation method is as follows：
By streblus asper leaf, Spilanthes oleracea, Murraya jasminorage leaf is dry, crush, 60% ethanol, immersion 2 are measured in 8-10 times of addition after mixing
Refluxing extraction 1 hour after hour, decoction filtration, filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filters, and merges
Filtrate, it is spray-dried after being concentrated under reduced pressure into small size, obtains streblus asper leaf, Spilanthes oleracea, Murraya jasminorage leaf mixed extract；
First the sorbierite of formula ratio, calcium phosphate dibasic dihydrate, xanthans and suitable quantity of water are added in vacuum Manufacturing medicine extract machine, filled
Divide and mix；Again by sldium lauryl sulfate, menthol, sodium benzoate, Mint Essence, pine nut elecampane oil, wintergreen leaf oil, blue gum
Leaf oil and suitable quantity of water are added in vacuum Manufacturing medicine extract machine, are fully mixed；It is eventually adding above-mentioned streblus asper leaf, Spilanthes oleracea, Murraya jasminorage leaf
Mixed extract and suitable quantity of water, the fully emulsified mixing of high-speed stirred, produce this plant toothpaste.
Comparative example 2
A kind of plant toothpaste of clearing heat and removing internal heat, it is made of the raw material of following weight parts：
Sorbierite 32, calcium phosphate dibasic dihydrate 32, sldium lauryl sulfate 1.8, menthol 0.3, Spilanthes oleracea extract 2.8,
Streblus asper leaf extract 4.5, Murraya jasminorage leaf extract 3.5, wintergreen leaf oil 2.0, blue gum leaf oil 2.8, sodium benzoate
0.15, xanthans 0.8, Mint Essence 1.0, water 22；
Preparation method is as follows：
Will streblus asper leaf is dry, crush after add 8-10 times and measure 30% ethanol, refluxing extraction 1 hour, medicine after immersion 2 hours
Liquid is filtered, and filtrate is standby, and 8 times of amount petroleum ethers are then added into filter residue：Ethyl acetate=5：1 mixed solvent, refluxing extraction 1 are small
When, filtering, merging filtrate, it is spray-dried after being concentrated under reduced pressure into small size, obtains streblus asper leaf extract；
8 times of amount ethanol will be added after Spilanthes oleracea drying, crushing：Ethyl acetate=3：1 mixed solvent, immersion are returned after 2 hours
Stream extraction 1 hour, decoction filtration, filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, subtracted
Pressure is spray-dried after being concentrated into small size, obtains Spilanthes oleracea extract；
Will Murraya jasminorage leaf is dry, crush after add 8-10 times and measure 60% ethanol, refluxing extraction 1 hour, medicine after immersion 2 hours
Liquid is filtered, and filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, are concentrated under reduced pressure into small size
After be spray-dried, obtain Murraya jasminorage leaf extract；
First the sorbierite of formula ratio, calcium phosphate dibasic dihydrate, xanthans and suitable quantity of water are added in vacuum Manufacturing medicine extract machine, filled
Divide and mix；Again by sldium lauryl sulfate, menthol, sodium benzoate, Mint Essence, wintergreen leaf oil, blue gum leaf oil and suitable
Amount water is added in vacuum Manufacturing medicine extract machine, is fully mixed；It is eventually adding in above-mentioned streblus asper leaf extract, Spilanthes oleracea extract, nine
Herba Pelargonii Graveolentis extract and suitable quantity of water, the fully emulsified mixing of high-speed stirred, produce this plant toothpaste.
Clinical test
(1) canker sore clinical test
This test objective is to observe and verify treatment of the plant toothpaste of the present invention (toothpaste in embodiment 1) to canker sore
Effect.
First, case selection and packet
Canker sore patient 120, is randomly divided into four groups：Control group (commercially available Chinese herbal medicine fire-clearing toothpaste), 1 group of embodiment,
1 group of comparative example, 2 groups of comparative example, every group each 30.
Each group age, sex, the course of disease, the not statistically significant (p of disease severity comparing difference>0.05).
2nd, diagnosis basis and inclusive criteria
(1) age requirement 18-60 one full year of life；
(2) Western medicine diagnostic criteria and TCM syndrome diagnostic criteria of canker sore are met；
(3) other treatment was not carried out in 2 weeks before testing；
(4) without other serious organ diseases.
3rd, exclusion standard
(1) age is below 18 one full year of life or 60 one full year of life above persons；
(2) other oral cavities serious disease person is suffered from；
(3) gestation and women breast-feeding their children；
(4) there are allergies or allergic constitution person to this toothpaste component；
(5) it is associated with the severe primary disease patient such as cardiovascular and cerebrovascular, liver, kidney, hemopoietic system, internal system；
(6) psychiatric patient.
4th, treatment method
Each test group toothpaste is taken, is respectively brushed teeth 1 time sooner or later using horizontal vibration method is daily, dosage is 2g/ times, brushes teeth 3 every time
Minute, allow toothpaste to be included in oral cavity during brushing teeth and gargle 3 minutes, be used continuously for 1 week.5th, curative effect determinate standard
Assess classification：
(1) fully recover：Canker sore heals completely；
(2) effectively：Heal canker sore part；
(3) it is invalid：Canker sore does not heal, even aggravate.
6th, treatment results
After treatment 7 days, each group clinical efficacy statistical result see the table below 1.
Each test group curative effect statistical form of table 1
| Group | Number of cases | Recovery from illness | Effectively | It is invalid | Total effective rate |
| Control group | 30 | 9 | 12 | 9 | 70% |
| 1 group of embodiment | 30 | 29 | 1 | 0 | 100% |
| 1 group of comparative example | 30 | 12 | 14 | 4 | 86.7% |
| 2 groups of comparative example | 30 | 10 | 15 | 5 | 83.3% |
From table 1 it follows that the cure rate and total effective rate of 1 group of toothpaste of embodiment are far above other each groups, illustrate this
The formula composition and preparation method of invention toothpaste have on its curative effect to be significantly affected.Using toothpaste of the present invention, although according to routed
The difference of the ulcer order of severity, its healing time is also different, but the interior healing in after use 2-4 days of most cases, more
Sum velocity is also apparently higher than other each groups.Therefore, it can reach using toothpaste of the present invention and improve ulcer healing rate, shorten ulcer healing
The purpose of time.
(2) swelling and aching of gum clinical test
This test objective is to observe and verify treatment of the plant toothpaste of the present invention (toothpaste in embodiment 1) to swelling and aching of gum
Effect.
First, case selection and packet
Swelling and aching of gum patient 120, is randomly divided into four groups：Control group (commercially available Chinese herbal medicine fire-clearing toothpaste), 1 group of embodiment,
1 group of comparative example, 2 groups of comparative example, every group each 30.
Each group age, sex, the course of disease, the not statistically significant (p of disease severity comparing difference>0.05).2nd, diagnose
Foundation and inclusive criteria
(1) age requirement 18-60 one full year of life；
(2) TCM syndrome diagnostic criteria of swelling and aching of gum is met；
(3) other treatment was not carried out in 2 weeks before testing；
(4) without other serious organ diseases.
3rd, exclusion standard：With canker sore clinical test.
4th, treatment method：With canker sore clinical test.
5th, curative effect determinate standard
Assess classification：
(1) fully recover：Swelling and aching of gum is wholly absent；
(2) effectively：Swelling and aching of gum is alleviated；
(3) it is invalid：Swelling and aching of gum is not alleviated, even aggravate.
6th, treatment results
After treatment 7 days, each group clinical efficacy statistical result see the table below 2.
Each test group curative effect statistical form of table 2
| Group | Number of cases | Recovery from illness | Effectively | It is invalid | Total effective rate |
| Control group | 30 | 10 | 7 | 13 | 56.7% |
| 1 group of embodiment | 30 | 16 | 12 | 2 | 93.3% |
| 1 group of comparative example | 30 | 4 | 19 | 7 | 76.7% |
| 2 groups of comparative example | 30 | 12 | 12 | 6 | 80.0% |
From Table 2, it can be seen that the cure rate and total effective rate of 1 group of toothpaste of embodiment are far above other each groups, illustrate this
The formula composition and preparation method of invention toothpaste have on its curative effect to be significantly affected.It can effectively alleviate tooth using toothpaste of the present invention
Gum red and swollen heat pain.
The preferred embodiments of the disclosure and embodiment are explained in detail above, but the present invention is not limited to
The above-described embodiment and examples, in those skilled in the art's possessed knowledge, the present invention can also not departed from
Various changes can be made on the premise of design.
Claims (9)
1. the plant toothpaste of a kind of clearing heat and removing internal heat, it is characterised in that it is made of the raw material of following weight parts：
NMF 30-35, rubbing agent 27-36, surfactant 1.6-2.0, freshener 0.2-0.5, Spilanthes oleracea extract 2.5-
3.0, streblus asper leaf extract 4.2-5.0, Murraya jasminorage leaf extract 3.2-3.6, pine nut elecampane oil 4.0-4.5, wintergreen leaf
Oily 1.8-2.2, blue gum leaf oil 2.6-3.0, preservative 0.1-0.2, thickener 0.6-1.0, flavouring agent 0.9-1.2, water 20-24；
The plant toothpaste is made by following steps：
Will streblus asper leaf is dry, crush after add 8-10 times and measure 30% ethanol, refluxing extraction 1 hour, decoction filter after immersion 2 hours
Cross, filtrate is standby, and 8 times of amount petroleum ethers are then added into filter residue：Ethyl acetate=5：1 mixed solvent, refluxing extraction 1 hour,
Filtering, merging filtrate, is spray-dried after being concentrated under reduced pressure into small size, obtains streblus asper leaf extract；
8 times of amount ethanol will be added after Spilanthes oleracea drying, crushing：Ethyl acetate=3：1 mixed solvent, immersion flow back after 2 hours and carried
Take 1 hour, decoction filtration, filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, depressurized dense
It is spray-dried after being reduced to small size, obtains Spilanthes oleracea extract；
Will Murraya jasminorage leaf is dry, crush after add 8-10 times and measure 60% ethanol, refluxing extraction 1 hour, decoction filter after immersion 2 hours
Cross, filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, sprayed after being concentrated under reduced pressure into small size
Mist is dried, and obtains Murraya jasminorage leaf extract；
First above-mentioned NMF, rubbing agent, thickener and the suitable quantity of water of formula ratio are added in vacuum Manufacturing medicine extract machine, fully mixed；
Again by surfactant, freshener, preservative, flavouring agent, pine nut elecampane oil, wintergreen leaf oil, blue gum leaf oil and suitable quantity of water
It is added in vacuum Manufacturing medicine extract machine, fully mixes；It is eventually adding streblus asper leaf extract, Spilanthes oleracea extract, Murraya jasminorage leaf extraction
Thing and suitable quantity of water, the fully emulsified mixing of high-speed stirred, produce this plant toothpaste.
2. the plant toothpaste of clearing heat and removing internal heat as claimed in claim 1, wherein the parts by weight of each raw material are：
NMF 30, rubbing agent 27, surfactant 1.6, freshener 0.2, Spilanthes oleracea extract 2.5, streblus asper leaf extract
4.2, Murraya jasminorage leaf extract 3.2, pine nut elecampane oil 4.0, wintergreen leaf oil 1.8, blue gum leaf oil 2.6, preservative 0.1, increase
Thick dose 0.6, flavouring agent 0.9, water 20.
3. the plant toothpaste of clearing heat and removing internal heat as claimed in claim 1, wherein the parts by weight of each raw material are：
NMF 32, rubbing agent 32, surfactant 1.8, freshener 0.3, Spilanthes oleracea extract 2.8, streblus asper leaf extract
4.5, Murraya jasminorage leaf extract 3.5, pine nut elecampane oil 4.2, wintergreen leaf oil 2.0, blue gum leaf oil 2.8, preservative 0.15, increase
Thick dose 0.8, flavouring agent 1.0, water 22.
4. the plant toothpaste of clearing heat and removing internal heat as claimed in claim 1, wherein the parts by weight of each raw material are：
NMF 35, rubbing agent 36, surfactant 2.0, freshener 0.5, Spilanthes oleracea extract 3.0, streblus asper leaf extract
5.0, Murraya jasminorage leaf extract 3.6, pine nut elecampane oil 4.5, wintergreen leaf oil 2.2, blue gum leaf oil 3.0, preservative 0.2, increase
Thick dose 1.0, flavouring agent 1.2, water 24.
5. the plant toothpaste of the clearing heat and removing internal heat as described in claim any one of 1-4, it is characterised in that：
The NMF is one or more of compositions in sorbierite, glycerine, propane diols, polyethylene glycol；
The rubbing agent is calcium phosphate dibasic dihydrate, hydrated silica, calcium carbonate, aluminium hydroxide, calcium pyrophosphate, calcium phosphate dibasic anhydrous
In one or more of compositions；
The surfactant is sldium lauryl sulfate, laurilsulfate sodium, one kind in sodium lauroyl sarcosine or several
The composition of kind；
The thickener is one or more of in sodium carboxymethylcellulose, xanthans, carragheen, guar gum, deer horn pectin
Composition；
The freshener is menthol；
The preservative is one or more of compositions in potassium sorbate, sodium benzoate；
The flavouring agent is one or more of compositions in Mint Essence, fruit essence, plants essential oil.
6. a kind of oral care plant composition, it is characterised in that it is made of the raw material of following weight parts：
Spilanthes oleracea extract 2.5-3.0, streblus asper leaf extract 4.2-5.0, Murraya jasminorage leaf extract 3.2-3.6；
The plant composition is made by following steps：
Will streblus asper leaf is dry, crush after add 8-10 times and measure 30% ethanol, refluxing extraction 1 hour, decoction filter after immersion 2 hours
Cross, filtrate is standby, and 8 times of amount petroleum ethers are then added into filter residue：Ethyl acetate=5：1 mixed solvent, refluxing extraction 1 hour,
Filtering, merging filtrate, is spray-dried after being concentrated under reduced pressure into small size, obtains streblus asper leaf extract；
8 times of amount ethanol will be added after Spilanthes oleracea drying, crushing：Ethyl acetate=3：1 mixed solvent, immersion flow back after 2 hours and carried
Take 1 hour, decoction filtration, filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, depressurized dense
It is spray-dried after being reduced to small size, obtains Spilanthes oleracea extract；
Will Murraya jasminorage leaf is dry, crush after add 8-10 times and measure 60% ethanol, refluxing extraction 1 hour, decoction filter after immersion 2 hours
Cross, filtrate is standby, and the dregs of a decoction are repeated into extraction 1 time under the same conditions, filtering, merging filtrate, sprayed after being concentrated under reduced pressure into small size
Mist is dried, and obtains Murraya jasminorage leaf extract；
Above-mentioned streblus asper leaf extract, Spilanthes oleracea extract, Murraya jasminorage leaf extract are well mixed, produce this plant society
Thing.
7. oral care plant composition as claimed in claim 6, it is characterised in that the oral care plant society is made
The raw material of thing also includes following weight parts：
Pine nut elecampane oil 4.0-4.5, wintergreen leaf oil 1.8-2.2, blue gum leaf oil 2.6-3.0.
8. oral care plant composition as claimed in claim 7, wherein the parts by weight of each raw material are：
Spilanthes oleracea extract 2.8, streblus asper leaf extract 4.5, Murraya jasminorage leaf extract 3.5, pine nut elecampane oil 4.2, white pearl of tiling
Leaf oil 2.0, blue gum leaf oil 2.8.
9. application of the oral care plant composition in following oral care implements are prepared as claimed in claims 6 or 7：Frost
Agent, ointment, gel, foaming agent, pulvis, lozenge, collutory.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108464956A (en) * | 2018-04-03 | 2018-08-31 | 弘美制药（中国）有限公司 | A kind of composition and the preparation method and application thereof applied to oral cavity |
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2017
- 2017-05-11 CN CN201710331393.8A patent/CN107412041A/en active Pending
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| RALOPA: ""Twin lotus, Recipe for Aqua Cool 双莲天然植物 冰泉固齿牙膏【冰爽薄荷香】", 《HTTP://WWW.COSDNA.COM/CHS/COSMETIC_83D1118981.HTML》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108464956A (en) * | 2018-04-03 | 2018-08-31 | 弘美制药（中国）有限公司 | A kind of composition and the preparation method and application thereof applied to oral cavity |
| CN108464956B (en) * | 2018-04-03 | 2020-07-10 | 弘美制药（中国）有限公司 | Composition applied to oral cavity and preparation method and application thereof |
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Application publication date: 20171201 |